JPH08509976A - コントラスト剤として使用するためのビシクロポリアザマクロシクロホスホン酸、それらの錯体および複合体ならびにそれらの製造方法 - Google Patents

コントラスト剤として使用するためのビシクロポリアザマクロシクロホスホン酸、それらの錯体および複合体ならびにそれらの製造方法

Info

Publication number
JPH08509976A
JPH08509976A JP6525356A JP52535694A JPH08509976A JP H08509976 A JPH08509976 A JP H08509976A JP 6525356 A JP6525356 A JP 6525356A JP 52535694 A JP52535694 A JP 52535694A JP H08509976 A JPH08509976 A JP H08509976A
Authority
JP
Japan
Prior art keywords
alkyl
terms
term
formula
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6525356A
Other languages
English (en)
Japanese (ja)
Inventor
キーフアー，ギヤリー・イー
サイモン，ジエイム
ガーリツチ，ジヨセフ・アール
Original Assignee
ザ・ダウ・ケミカル・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ダウ・ケミカル・カンパニー filed Critical ザ・ダウ・ケミカル・カンパニー
Publication of JPH08509976A publication Critical patent/JPH08509976A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
JP6525356A 1993-05-06 1993-05-06 コントラスト剤として使用するためのビシクロポリアザマクロシクロホスホン酸、それらの錯体および複合体ならびにそれらの製造方法 Pending JPH08509976A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004325 WO1994026754A1 (en) 1993-05-06 1993-05-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Publications (1)

Publication Number Publication Date
JPH08509976A true JPH08509976A (ja) 1996-10-22

Family

ID=22236574

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6525356A Pending JPH08509976A (ja) 1993-05-06 1993-05-06 コントラスト剤として使用するためのビシクロポリアザマクロシクロホスホン酸、それらの錯体および複合体ならびにそれらの製造方法

Country Status (8)

Country Link
EP (1) EP0696290A1 (ko)
JP (1) JPH08509976A (ko)
KR (2) KR960702470A (ko)
AU (1) AU665689B2 (ko)
FI (2) FI933507A (ko)
NO (2) NO304985B1 (ko)
NZ (1) NZ252554A (ko)
WO (1) WO1994026754A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc NITROGEN MACROCYCLIC COMPOUNDS
EP0898574B1 (en) * 1996-04-19 2003-11-12 Dow Global Technologies Inc. Fluorescent chelates as visual tissue specific imaging agents
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN106518896A (zh) * 2016-10-27 2017-03-22 南京大学 锌‑四氮环配合物及其制备方法和在抗肿瘤药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636632B1 (fr) * 1988-09-16 1996-02-02 Oris Ind Produits radiopharmaceutiques constitues par des complexes de tc, re ou y comportant des ligands tetraphosphonates et leur preparation
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
WO1991010669A1 (en) * 1990-01-19 1991-07-25 Cockbain, Julian, Roderick, Michaelson Chelating compounds
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
IL104060A (en) * 1991-12-10 1998-12-06 Dow Chemical Co Bicyclopolyazamacyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Also Published As

Publication number Publication date
NO954442D0 (no) 1995-11-06
NO932823D0 (no) 1993-08-09
KR960702470A (ko) 1996-04-27
FI933507A0 (fi) 1993-08-09
NO304985B1 (no) 1999-03-15
AU665689B2 (en) 1996-01-11
NZ252554A (en) 1998-01-26
FI955335A0 (fi) 1995-11-06
EP0696290A1 (en) 1996-02-14
AU4238293A (en) 1994-12-12
KR950700916A (ko) 1995-02-20
FI933507A (fi) 1994-11-07
NO932823L (no) 1993-10-08
NO954442L (no) 1996-01-05
WO1994026754A1 (en) 1994-11-24

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