NO304985B1 - Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og farmas°ytisk formulering - Google Patents

Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og farmas°ytisk formulering

Info

Publication number
NO304985B1
NO304985B1 NO932823A NO932823A NO304985B1 NO 304985 B1 NO304985 B1 NO 304985B1 NO 932823 A NO932823 A NO 932823A NO 932823 A NO932823 A NO 932823A NO 304985 B1 NO304985 B1 NO 304985B1
Authority
NO
Norway
Prior art keywords
complexes
pharmaceutical formulation
bicyclopolyazamacrocyclophosphonic
acids
bicyclopolyazamacrocyclophosphonic acids
Prior art date
Application number
NO932823A
Other languages
English (en)
Other versions
NO932823D0 (no
NO932823L (no
Inventor
Garry E Kiefer
Joseph R Garlich
Jaime Simon
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of NO932823D0 publication Critical patent/NO932823D0/no
Publication of NO932823L publication Critical patent/NO932823L/no
Publication of NO304985B1 publication Critical patent/NO304985B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO932823A 1993-05-06 1993-08-09 Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og farmas°ytisk formulering NO304985B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/004325 WO1994026754A1 (en) 1993-05-06 1993-05-06 Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation

Publications (3)

Publication Number Publication Date
NO932823D0 NO932823D0 (no) 1993-08-09
NO932823L NO932823L (no) 1993-10-08
NO304985B1 true NO304985B1 (no) 1999-03-15

Family

ID=22236574

Family Applications (2)

Application Number Title Priority Date Filing Date
NO932823A NO304985B1 (no) 1993-05-06 1993-08-09 Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og farmas°ytisk formulering
NO954442A NO954442L (no) 1993-05-06 1995-11-06 Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO954442A NO954442L (no) 1993-05-06 1995-11-06 Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling

Country Status (8)

Country Link
EP (1) EP0696290A1 (no)
JP (1) JPH08509976A (no)
KR (2) KR960702470A (no)
AU (1) AU665689B2 (no)
FI (2) FI933507A (no)
NO (2) NO304985B1 (no)
NZ (1) NZ252554A (no)
WO (1) WO1994026754A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) * 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc NITROGEN MACROCYCLIC COMPOUNDS
ATE254129T1 (de) * 1996-04-19 2003-11-15 Dow Global Technologies Inc Fluoreszierende chelate als gewebespezifische bildgebende mittel
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
CN106518896A (zh) * 2016-10-27 2017-03-22 南京大学 锌‑四氮环配合物及其制备方法和在抗肿瘤药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636632B1 (fr) * 1988-09-16 1996-02-02 Oris Ind Produits radiopharmaceutiques constitues par des complexes de tc, re ou y comportant des ligands tetraphosphonates et leur preparation
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
EP0511275A1 (en) * 1990-01-19 1992-11-04 Nycomed Imaging As Chelating compounds
DE69223504T2 (de) * 1991-12-10 1998-04-02 The Dow Chemical Co., Midland, Mich. Bicycloazamakrocyclophosphon-Säure, Komplexe, Konjugate, Kontrastmittel und Herstellung

Also Published As

Publication number Publication date
FI955335A0 (fi) 1995-11-06
NZ252554A (en) 1998-01-26
FI933507A (fi) 1994-11-07
NO932823D0 (no) 1993-08-09
NO932823L (no) 1993-10-08
AU4238293A (en) 1994-12-12
JPH08509976A (ja) 1996-10-22
FI933507A0 (fi) 1993-08-09
NO954442D0 (no) 1995-11-06
KR950700916A (ko) 1995-02-20
NO954442L (no) 1996-01-05
EP0696290A1 (en) 1996-02-14
WO1994026754A1 (en) 1994-11-24
KR960702470A (ko) 1996-04-27
AU665689B2 (en) 1996-01-11

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