RU93053897A - BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PHARMACEUTICAL COMPOSITION, DIAGNOSTIC METHOD, SET AND METHOD FOR PRODUCING - Google Patents

BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PHARMACEUTICAL COMPOSITION, DIAGNOSTIC METHOD, SET AND METHOD FOR PRODUCING

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Publication number
RU93053897A
RU93053897A RU93053897/04A RU93053897A RU93053897A RU 93053897 A RU93053897 A RU 93053897A RU 93053897/04 A RU93053897/04 A RU 93053897/04A RU 93053897 A RU93053897 A RU 93053897A RU 93053897 A RU93053897 A RU 93053897A
Authority
RU
Russia
Prior art keywords
conjugates
producing
pharmaceutical composition
acid complexes
complexes
Prior art date
Application number
RU93053897/04A
Other languages
Russian (ru)
Inventor
Е.Кифер Гэрри
Саймон Джейм
Original Assignee
Дзе Дау Кемикал Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Дау Кемикал Компани filed Critical Дзе Дау Кемикал Компани
Publication of RU93053897A publication Critical patent/RU93053897A/en

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Claims (1)

Описываются комплексы бициклополиазамакроциклокарбоновой кислоты с ионами Gd, Mn или Fe. Эти комплексы могут ковалентно присоединяться к биологически активным молекулам, например антителам или фрагментам антител, образуя конъюгаты. Комплексы и конъюгаты полезны в качестве контрастных агентов для целей диагностики. Раскрываются процессы получения и комплекса, и конъюгата.The complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn, or Fe ions are described. These complexes can covalently attach to biologically active molecules, such as antibodies or antibody fragments, to form conjugates. Complexes and conjugates are useful as contrast agents for diagnostic purposes. The processes of obtaining both the complex and the conjugate are disclosed.
RU93053897/04A 1991-12-10 1992-12-10 BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PHARMACEUTICAL COMPOSITION, DIAGNOSTIC METHOD, SET AND METHOD FOR PRODUCING RU93053897A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/805,270 1991-12-10

Publications (1)

Publication Number Publication Date
RU93053897A true RU93053897A (en) 1996-10-10

Family

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