ATE549036T1 - Thymosin-alpha-1-peptid/polymer-konjugate - Google Patents
Thymosin-alpha-1-peptid/polymer-konjugateInfo
- Publication number
- ATE549036T1 ATE549036T1 AT02789368T AT02789368T ATE549036T1 AT E549036 T1 ATE549036 T1 AT E549036T1 AT 02789368 T AT02789368 T AT 02789368T AT 02789368 T AT02789368 T AT 02789368T AT E549036 T1 ATE549036 T1 AT E549036T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- polymer conjugates
- alpha
- thymosine
- administered
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 108010078233 Thymalfasin Proteins 0.000 abstract 4
- 102400000800 Thymosin alpha-1 Human genes 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 2
- 229960004231 thymalfasin Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33087001P | 2001-11-01 | 2001-11-01 | |
| PCT/US2002/035094 WO2003037272A2 (en) | 2001-11-01 | 2002-11-01 | Thymosin alpha 1 peptide/polymer conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE549036T1 true ATE549036T1 (de) | 2012-03-15 |
Family
ID=23291654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02789368T ATE549036T1 (de) | 2001-11-01 | 2002-11-01 | Thymosin-alpha-1-peptid/polymer-konjugate |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7297676B2 (de) |
| EP (1) | EP1455766B1 (de) |
| JP (1) | JP2005511553A (de) |
| KR (1) | KR20050042230A (de) |
| CN (1) | CN100536910C (de) |
| AT (1) | ATE549036T1 (de) |
| AU (1) | AU2002353964B2 (de) |
| BR (1) | BR0213821A (de) |
| CA (1) | CA2465874A1 (de) |
| EA (1) | EA008703B1 (de) |
| IL (1) | IL161670A0 (de) |
| MX (1) | MXPA04004188A (de) |
| NO (1) | NO20042055L (de) |
| NZ (1) | NZ532719A (de) |
| PL (1) | PL373795A1 (de) |
| UA (1) | UA78726C2 (de) |
| WO (1) | WO2003037272A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0316646A (pt) | 2002-11-25 | 2005-10-11 | Sciclone Pharmaceuticals Inc | Método de proteção contra os danos causados pela radiação utilizando timosina alfa |
| EA010016B1 (ru) * | 2003-05-12 | 2008-06-30 | Афимакс, Инк. | Новые модифицированные полиэтиленгликолем соединения и их применение |
| DE602004017726D1 (de) * | 2003-06-30 | 2008-12-24 | Domantis Ltd | Pegylierte Single-domain-antikörper (dAb) |
| CN100355786C (zh) * | 2004-04-28 | 2007-12-19 | 江苏豪森药业股份有限公司 | 聚乙二醇修饰的胸腺肽1衍生物 |
| CN1314708C (zh) * | 2004-05-24 | 2007-05-09 | 华东师范大学 | 一种人α1－胸腺肽的复合物及其制备方法 |
| CN100500844C (zh) * | 2005-03-07 | 2009-06-17 | 上海普洛康裕药物研究院有限公司 | 重组胸腺素α1在大肠杆菌中的高分泌表达和分离纯化 |
| CN100577685C (zh) | 2005-11-10 | 2010-01-06 | 中国人民解放军军事医学科学院毒物药物研究所 | 长效胸腺素α1的聚乙二醇化修饰物 |
| CN101062950B (zh) * | 2006-04-25 | 2010-04-21 | 江苏豪森药业股份有限公司 | 聚乙二醇修饰的胸腺肽1衍生物 |
| US8017129B2 (en) * | 2006-06-15 | 2011-09-13 | SciClone Pharmaceuticals International Ltd | Use of thymosin alpha 1 for preparing a medicament for the treatment of stage IV malignant melanoma |
| US20080300166A1 (en) * | 2007-06-01 | 2008-12-04 | Sciclone Pharmaceuticals, Inc. | Treatment of Melanoma with Alpha Thymosin Peptides |
| EP2344199A1 (de) * | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Polymer-konjugate von thymosin-alpha1-peptiden |
| EP2898900B1 (de) | 2008-09-19 | 2017-11-15 | Nektar Therapeutics | Polymerkonjugate von Ziconotid |
| US8716012B2 (en) * | 2009-05-08 | 2014-05-06 | Sciclone Pharmaceuticals, Inc. | Alpha thymosin peptides as vaccine enhancers |
| CA2873529C (en) * | 2012-05-18 | 2020-08-18 | Replicor Inc. | Oligonucleotide chelate complex-polypeptide compositions and methods |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4079127A (en) * | 1976-10-28 | 1978-03-14 | Board Of Regents Of The University Of Texas | Thymosin alpha 1 |
| US4116951A (en) | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
| US4148788A (en) | 1978-01-23 | 1979-04-10 | Hoffmann-La Roche Inc. | Synthesis of thymosin α1 |
| DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4917888A (en) * | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5308833A (en) * | 1992-02-06 | 1994-05-03 | Sciclone Pharmaceuticals | Method for treating hepatitis B carriers with minimal disease |
| AU5006993A (en) * | 1992-08-21 | 1994-03-15 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
| CN1094310A (zh) * | 1992-12-15 | 1994-11-02 | 托马斯·C·梅里根 | 人体免疫缺陷性病毒感染用组合式化学疗法 |
| PT730470E (pt) | 1993-11-10 | 2002-08-30 | Enzon Inc | Conjugados melhorados de interferao-polimero |
| US5632983A (en) * | 1994-11-17 | 1997-05-27 | University Of South Florida | Method for treating secondary immunodeficiency |
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| AU725133B2 (en) * | 1997-01-15 | 2000-10-05 | Polaris Group | Modified tumor necrosis factor |
| CN1323345A (zh) * | 1998-10-13 | 2001-11-21 | 诺沃奇梅兹有限公司 | 具有降低的免疫应答的修饰多肽 |
| US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
| AU2001244602A1 (en) * | 2000-03-30 | 2001-10-15 | Ajinomoto Co. Inc. | Drugs retained in target tissue over long time |
| WO2002036169A2 (en) * | 2000-10-31 | 2002-05-10 | Pr Pharmaceuticals, Inc. | Methods and compositions for enhanced delivery of bioactive molecules |
| US7610156B2 (en) * | 2003-03-31 | 2009-10-27 | Xencor, Inc. | Methods for rational pegylation of proteins |
-
2002
- 2002-01-11 UA UA20040504065A patent/UA78726C2/uk unknown
- 2002-11-01 IL IL16167002A patent/IL161670A0/xx unknown
- 2002-11-01 PL PL02373795A patent/PL373795A1/xx unknown
- 2002-11-01 CN CNB028218728A patent/CN100536910C/zh not_active Expired - Lifetime
- 2002-11-01 EP EP02789368A patent/EP1455766B1/de not_active Expired - Lifetime
- 2002-11-01 US US10/493,690 patent/US7297676B2/en not_active Expired - Lifetime
- 2002-11-01 CA CA002465874A patent/CA2465874A1/en not_active Abandoned
- 2002-11-01 AU AU2002353964A patent/AU2002353964B2/en not_active Ceased
- 2002-11-01 KR KR1020047006675A patent/KR20050042230A/ko not_active Ceased
- 2002-11-01 WO PCT/US2002/035094 patent/WO2003037272A2/en not_active Ceased
- 2002-11-01 MX MXPA04004188A patent/MXPA04004188A/es active IP Right Grant
- 2002-11-01 NZ NZ532719A patent/NZ532719A/en not_active IP Right Cessation
- 2002-11-01 EA EA200400592A patent/EA008703B1/ru not_active IP Right Cessation
- 2002-11-01 BR BR0213821-2A patent/BR0213821A/pt not_active IP Right Cessation
- 2002-11-01 AT AT02789368T patent/ATE549036T1/de active
- 2002-11-01 JP JP2003539618A patent/JP2005511553A/ja active Pending
-
2004
- 2004-05-18 NO NO20042055A patent/NO20042055L/no not_active Application Discontinuation
-
2007
- 2007-10-02 US US11/865,816 patent/US20080152668A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1455766B1 (de) | 2012-03-14 |
| CN100536910C (zh) | 2009-09-09 |
| US20080152668A1 (en) | 2008-06-26 |
| EP1455766A2 (de) | 2004-09-15 |
| JP2005511553A (ja) | 2005-04-28 |
| WO2003037272A3 (en) | 2003-11-20 |
| US20040248792A1 (en) | 2004-12-09 |
| EA008703B1 (ru) | 2007-06-29 |
| AU2002353964B2 (en) | 2006-08-03 |
| IL161670A0 (en) | 2004-09-27 |
| EA200400592A1 (ru) | 2004-12-30 |
| NO20042055L (no) | 2004-05-18 |
| US7297676B2 (en) | 2007-11-20 |
| BR0213821A (pt) | 2004-08-31 |
| MXPA04004188A (es) | 2004-07-08 |
| WO2003037272A2 (en) | 2003-05-08 |
| UA78726C2 (en) | 2007-04-25 |
| NZ532719A (en) | 2005-11-25 |
| KR20050042230A (ko) | 2005-05-06 |
| CN1582162A (zh) | 2005-02-16 |
| CA2465874A1 (en) | 2003-05-08 |
| EP1455766A4 (de) | 2008-11-05 |
| PL373795A1 (en) | 2005-09-19 |
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