MX338336B - Polipeptidos de insulina modificados y sus usos. - Google Patents

Polipeptidos de insulina modificados y sus usos.

Info

Publication number
MX338336B
MX338336B MX2013013295A MX2013013295A MX338336B MX 338336 B MX338336 B MX 338336B MX 2013013295 A MX2013013295 A MX 2013013295A MX 2013013295 A MX2013013295 A MX 2013013295A MX 338336 B MX338336 B MX 338336B
Authority
MX
Mexico
Prior art keywords
insulin polypeptides
modified insulin
polypeptides
modified
insulin
Prior art date
Application number
MX2013013295A
Other languages
English (en)
Inventor
Lillian Ho
Zhenwei Miao
Nick Knudsen
Vadim Kraynov
Feng Tian
Bee-Cheng Sim
Denise Krawitz
Anna-Maria A Hays Putnam
Michael Deguzman
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX338336B publication Critical patent/MX338336B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Abstract

La presente invención se refiere a un polipéptido de insulina que comprende: (i) una secuencia de aminoácidos de la cadena A de insulina modificada establecida en SEQ ID NO: 1 o SEQ ID NO: 3 SEQ ID NO: 5 o SEQ ID NO: 7 o SEQ ID NO: 9 o SEQ ID NO: 11 en donde el residuo de tirosina en la posición 14 de la misma es sustituida por un aminoácido no naturalmente codificado (NEAA) y (ii) una molécula de lípido ligado covalentemente mediante un enlace oxima a dicho NEAA .
MX2013013295A 2007-11-20 2008-11-20 Polipeptidos de insulina modificados y sus usos. MX338336B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98938807P 2007-11-20 2007-11-20
PCT/US2008/084252 WO2009067636A2 (en) 2007-11-20 2008-11-20 Modified insulin polypeptides and their uses

Publications (1)

Publication Number Publication Date
MX338336B true MX338336B (es) 2016-04-07

Family

ID=40668091

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010005317A MX2010005317A (es) 2007-11-20 2008-11-20 Polipeptidos de insulina modificados y sus usos.
MX2013013295A MX338336B (es) 2007-11-20 2008-11-20 Polipeptidos de insulina modificados y sus usos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010005317A MX2010005317A (es) 2007-11-20 2008-11-20 Polipeptidos de insulina modificados y sus usos.

Country Status (13)

Country Link
US (2) US8946148B2 (es)
EP (2) EP2217265B1 (es)
JP (2) JP5547083B2 (es)
KR (1) KR101656107B1 (es)
CN (1) CN101918026B (es)
AU (1) AU2008326324B9 (es)
CA (1) CA2703830A1 (es)
DK (1) DK2217265T3 (es)
ES (1) ES2632504T3 (es)
IL (2) IL205579A (es)
MX (2) MX2010005317A (es)
NZ (2) NZ584825A (es)
WO (1) WO2009067636A2 (es)

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WO2009067636A2 (en) 2009-05-28
IL205579A0 (en) 2010-11-30
MX2010005317A (es) 2010-06-02
CA2703830A1 (en) 2009-05-28
EP2930182A1 (en) 2015-10-14
EP2217265A2 (en) 2010-08-18
US20150299288A1 (en) 2015-10-22
JP2011504187A (ja) 2011-02-03
NZ584825A (en) 2013-03-28
CN101918026A (zh) 2010-12-15
AU2008326324B9 (en) 2012-11-15
DK2217265T3 (en) 2017-07-03
KR20100108524A (ko) 2010-10-07
NZ603812A (en) 2014-06-27
JP5547083B2 (ja) 2014-07-09
IL205579A (en) 2016-07-31
JP2014169313A (ja) 2014-09-18
IL237314A (en) 2017-02-28
US20100298212A1 (en) 2010-11-25
KR101656107B1 (ko) 2016-09-08
ES2632504T3 (es) 2017-09-13
EP2217265A4 (en) 2011-01-05
AU2008326324B2 (en) 2012-07-05
IL237314A0 (en) 2015-04-30
EP2217265B1 (en) 2017-05-10
AU2008326324A1 (en) 2009-05-28
US8946148B2 (en) 2015-02-03

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