BR112022025667A2 - Métodos de tratamento da doença inflamatória intestinal com anticorpos tl1a - Google Patents
Métodos de tratamento da doença inflamatória intestinal com anticorpos tl1aInfo
- Publication number
- BR112022025667A2 BR112022025667A2 BR112022025667A BR112022025667A BR112022025667A2 BR 112022025667 A2 BR112022025667 A2 BR 112022025667A2 BR 112022025667 A BR112022025667 A BR 112022025667A BR 112022025667 A BR112022025667 A BR 112022025667A BR 112022025667 A2 BR112022025667 A2 BR 112022025667A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- induction
- dosage regimen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
MÉTODOS DE TRATAMENTO DA DOENÇA INFLAMATÓRIA INTESTINAL COM ANTICORPOS TL1A. A presente invenção refere-se a um método para tratar a doença inflamatória intestinal (DII) em um paciente, o método compreendendo a administração ao paciente de um anticorpo de ligante semelhante a anti-TNF 1A (TL1A) em um regime de dosagem de indução suficiente para melhorar os sinais e sintomas de DII por pelo menos 12 semanas após o início do tratamento com o anticorpo anti-TL1A, o referido regime de dosagem de indução compreendendo uma pluralidade de doses de indução individuais, em que o método compreende também a administração ao paciente de um regime de dosagem de manutenção subsequente após a conclusão do regime de dosagem de indução, o referido regime de dosagem de manutenção compreendendo uma pluralidade de doses de manutenção individuais separadas umas das outras por pelo menos 2 semanas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063044390P | 2020-06-26 | 2020-06-26 | |
PCT/IB2021/055546 WO2021260577A2 (en) | 2020-06-26 | 2021-06-23 | Methods of treating inflammatory bowel disease with tl1a antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022025667A2 true BR112022025667A2 (pt) | 2023-03-07 |
Family
ID=76730925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022025667A BR112022025667A2 (pt) | 2020-06-26 | 2021-06-23 | Métodos de tratamento da doença inflamatória intestinal com anticorpos tl1a |
Country Status (9)
Country | Link |
---|---|
US (1) | US20230235070A1 (pt) |
EP (1) | EP4171632A2 (pt) |
JP (1) | JP2022022994A (pt) |
KR (1) | KR20230025898A (pt) |
CN (1) | CN116322762A (pt) |
BR (1) | BR112022025667A2 (pt) |
CA (1) | CA3187966A1 (pt) |
MX (1) | MX2022016590A (pt) |
WO (1) | WO2021260577A2 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA52366A (fr) | 2018-04-25 | 2021-03-03 | Prometheus Biosciences Inc | Anticorps anti-tl1a optimisés |
TW202346344A (zh) * | 2022-01-07 | 2023-12-01 | 美商普羅米修斯生物科學股份有限公司 | 以tl1a抑制劑及il23抑制劑的組合治療發炎疾病之方法 |
WO2024026395A1 (en) | 2022-07-27 | 2024-02-01 | Cephalon Llc | Anti-tl1a antibodies for the treatment of ulcerative colitis and crohn's disease |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5278299A (en) | 1991-03-18 | 1994-01-11 | Scripps Clinic And Research Foundation | Method and composition for synthesizing sialylated glycosyl compounds |
WO1993010260A1 (en) | 1991-11-21 | 1993-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases |
AU2006236508B2 (en) | 2005-04-15 | 2012-02-02 | Precision Biologics, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
EP3041580A4 (en) * | 2013-09-06 | 2017-05-03 | Cedars-Sinai Medical Center | Systems, devices and methods for anti-tl1a therapy |
CA3056647A1 (en) * | 2013-11-13 | 2015-05-21 | Robert ARCH | Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof |
KR20230003433A (ko) * | 2016-05-20 | 2023-01-05 | 세다르스-신나이 메디칼 센터 | 유전자에 기반한 염증성 장 질환의 진단 |
MY191324A (en) * | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
MA52366A (fr) * | 2018-04-25 | 2021-03-03 | Prometheus Biosciences Inc | Anticorps anti-tl1a optimisés |
-
2021
- 2021-06-23 CN CN202180052476.8A patent/CN116322762A/zh active Pending
- 2021-06-23 WO PCT/IB2021/055546 patent/WO2021260577A2/en active Application Filing
- 2021-06-23 JP JP2021103691A patent/JP2022022994A/ja active Pending
- 2021-06-23 CA CA3187966A patent/CA3187966A1/en active Pending
- 2021-06-23 KR KR1020237002289A patent/KR20230025898A/ko not_active Application Discontinuation
- 2021-06-23 US US18/002,368 patent/US20230235070A1/en active Pending
- 2021-06-23 BR BR112022025667A patent/BR112022025667A2/pt unknown
- 2021-06-23 EP EP21736707.7A patent/EP4171632A2/en active Pending
- 2021-06-23 MX MX2022016590A patent/MX2022016590A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN116322762A (zh) | 2023-06-23 |
WO2021260577A3 (en) | 2022-04-28 |
EP4171632A2 (en) | 2023-05-03 |
MX2022016590A (es) | 2023-02-01 |
WO2021260577A2 (en) | 2021-12-30 |
US20230235070A1 (en) | 2023-07-27 |
JP2022022994A (ja) | 2022-02-07 |
CA3187966A1 (en) | 2021-12-30 |
KR20230025898A (ko) | 2023-02-23 |
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B25G | Requested change of headquarter approved |
Owner name: PFIZER INC. (US) |