PE20170471A1 - Polipeptidos receptores formulados y metodos relacionados - Google Patents
Polipeptidos receptores formulados y metodos relacionadosInfo
- Publication number
- PE20170471A1 PE20170471A1 PE2016002711A PE2016002711A PE20170471A1 PE 20170471 A1 PE20170471 A1 PE 20170471A1 PE 2016002711 A PE2016002711 A PE 2016002711A PE 2016002711 A PE2016002711 A PE 2016002711A PE 20170471 A1 PE20170471 A1 PE 20170471A1
- Authority
- PE
- Peru
- Prior art keywords
- formulated
- related methods
- receptor polypeptides
- polypeptide
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Se refiere a una composicion que comprende una solucion de una proteina que comprende un polipeptido con una secuencia de aminoacidos SEQ ID NO: 4, 6, 12 y 14, un tampon tal como fosfato de sodio, un tensioactivo tal como polisorbato 20 y un excipiente tal como sacarosa, donde dicho polipeptido es capaz de ligarse a miostatina, activina A o GDF-11. Dicha composicion es util en el tratamiento de caquexia
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462012104P | 2014-06-13 | 2014-06-13 | |
US201462047995P | 2014-09-09 | 2014-09-09 | |
US201462058789P | 2014-10-02 | 2014-10-02 | |
US201562142812P | 2015-04-03 | 2015-04-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20170471A1 true PE20170471A1 (es) | 2017-05-14 |
Family
ID=54834575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016002711A PE20170471A1 (es) | 2014-06-13 | 2015-06-15 | Polipeptidos receptores formulados y metodos relacionados |
Country Status (19)
Country | Link |
---|---|
US (1) | US20170202909A1 (es) |
EP (1) | EP3155008B1 (es) |
JP (1) | JP2017519009A (es) |
KR (1) | KR20170035891A (es) |
CN (1) | CN107074931A (es) |
AP (1) | AP2016009647A0 (es) |
AU (1) | AU2015274293A1 (es) |
BR (1) | BR112016029211A2 (es) |
CA (1) | CA2952231A1 (es) |
CL (1) | CL2016003191A1 (es) |
EA (1) | EA201692568A1 (es) |
IL (1) | IL249373A0 (es) |
MX (1) | MX2016016281A (es) |
PE (1) | PE20170471A1 (es) |
PH (1) | PH12016502479A1 (es) |
SG (1) | SG11201610432UA (es) |
TN (1) | TN2016000551A1 (es) |
TW (1) | TW201625675A (es) |
WO (1) | WO2015192127A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5261187B2 (ja) | 2005-11-23 | 2013-08-14 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIaアンタゴニストおよび骨成長を促進するための使用 |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
TWI480048B (zh) | 2007-02-01 | 2015-04-11 | Acceleron Pharma Inc | 活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途 |
TWI548647B (zh) | 2007-02-02 | 2016-09-11 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
CN104548056B (zh) | 2007-02-09 | 2022-09-09 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和促进癌症患者骨骼生长的用途 |
CN107412734A (zh) | 2007-09-18 | 2017-12-01 | 阿塞勒隆制药公司 | 活化素‑actriia拮抗剂和减少或抑制fsh分泌的用途 |
PT3494986T (pt) | 2008-08-14 | 2020-07-14 | Acceleron Pharma Inc | Armadilhas para gdf |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
EP2440576A4 (en) | 2009-06-08 | 2013-11-20 | Acceleron Pharma Inc | PROCESS FOR INCREASING THE NUMBER OF THERMOUS ADIPOCYTES |
KR20120028358A (ko) | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
AU2011326586A1 (en) | 2010-11-08 | 2013-05-30 | Acceleron Pharma, Inc. | ActRIIA binding agents and uses thereof |
WO2014071158A1 (en) | 2012-11-02 | 2014-05-08 | Celgene Corporation | Activin-actrii antagonists and uses for treating bone and other disorders |
CA2899889A1 (en) | 2013-02-01 | 2014-08-07 | Santa Maria Biotherapeutics, Inc. | Administration of an anti-activin-a compound to a subject |
EP3154566B1 (en) | 2014-06-13 | 2022-08-03 | Acceleron Pharma Inc. | Actrii antagonist for the treatment or prevention of a cutaneous ulcer in a subject that has anemia |
SI3286206T1 (sl) | 2015-04-22 | 2021-07-30 | Biogen Ma Inc. | Novi hibridni proteini ligandske pasti actriib za zdravljenje bolezni zaradi izgube mišične mase |
CN110430890A (zh) | 2016-11-10 | 2019-11-08 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
EP3679945A4 (en) * | 2017-09-07 | 2021-06-16 | JCR Pharmaceuticals Co., Ltd. | AQUEOUS PHARMACEUTICAL COMPOSITION |
US11484573B2 (en) | 2017-11-09 | 2022-11-01 | Keros Therapeutics, Inc. | Activin receptor type IIa variants and methods of use thereof |
EP3737406A4 (en) | 2018-01-12 | 2021-11-03 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIB VARIANTS AND THEIR METHODS OF USE |
CA3108920A1 (en) * | 2018-08-29 | 2020-03-05 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
JP2877509B2 (ja) | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | メタロプロテイナーゼ阻害剤 |
NZ512105A (en) | 1998-11-13 | 2004-04-30 | Immunex Corp | Human TSLP DNA and polypeptides |
JP4038118B2 (ja) | 2002-11-29 | 2008-01-23 | 株式会社コガネイ | 流体圧シリンダ |
US9283260B2 (en) * | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
TWI573802B (zh) * | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
NZ621174A (en) * | 2008-01-15 | 2015-09-25 | Abbvie Deutschland | Powdered protein compositions and methods of making same |
EP2370463B1 (en) * | 2008-11-26 | 2016-08-31 | Amgen Inc. | A stabilized variant of activin iib receptor |
RU2600847C2 (ru) * | 2010-05-10 | 2016-10-27 | Интас Биофармасьютикалс Лимитед | Жидкий состав полипептидов, содержащих fc-домен иммуноглобулина |
US9401875B2 (en) | 2012-06-01 | 2016-07-26 | Nippon Telegraph And Telephone Corporation | Packet transfer processing method and packet transfer processing device |
CA2899889A1 (en) * | 2013-02-01 | 2014-08-07 | Santa Maria Biotherapeutics, Inc. | Administration of an anti-activin-a compound to a subject |
US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
WO2016205370A1 (en) * | 2015-06-15 | 2016-12-22 | Santa Maria Biotherapeutics, Inc. | Methods of using activin receptor iib-based proteins |
-
2015
- 2015-06-15 AP AP2016009647A patent/AP2016009647A0/en unknown
- 2015-06-15 TN TN2016000551A patent/TN2016000551A1/en unknown
- 2015-06-15 BR BR112016029211A patent/BR112016029211A2/pt not_active Application Discontinuation
- 2015-06-15 US US15/316,767 patent/US20170202909A1/en not_active Abandoned
- 2015-06-15 EA EA201692568A patent/EA201692568A1/ru unknown
- 2015-06-15 JP JP2016572730A patent/JP2017519009A/ja active Pending
- 2015-06-15 CN CN201580043173.4A patent/CN107074931A/zh active Pending
- 2015-06-15 TW TW104119310A patent/TW201625675A/zh unknown
- 2015-06-15 KR KR1020177001016A patent/KR20170035891A/ko unknown
- 2015-06-15 MX MX2016016281A patent/MX2016016281A/es unknown
- 2015-06-15 AU AU2015274293A patent/AU2015274293A1/en not_active Abandoned
- 2015-06-15 SG SG11201610432UA patent/SG11201610432UA/en unknown
- 2015-06-15 CA CA2952231A patent/CA2952231A1/en active Pending
- 2015-06-15 WO PCT/US2015/035818 patent/WO2015192127A2/en active Application Filing
- 2015-06-15 PE PE2016002711A patent/PE20170471A1/es not_active Application Discontinuation
- 2015-06-15 EP EP15805829.7A patent/EP3155008B1/en active Active
-
2016
- 2016-12-04 IL IL249373A patent/IL249373A0/en unknown
- 2016-12-12 PH PH12016502479A patent/PH12016502479A1/en unknown
- 2016-12-13 CL CL2016003191A patent/CL2016003191A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AP2016009647A0 (en) | 2016-12-31 |
US20170202909A1 (en) | 2017-07-20 |
EA201692568A1 (ru) | 2017-05-31 |
EP3155008B1 (en) | 2020-08-26 |
EP3155008A4 (en) | 2018-05-16 |
JP2017519009A (ja) | 2017-07-13 |
WO2015192127A2 (en) | 2015-12-17 |
EP3155008A2 (en) | 2017-04-19 |
BR112016029211A2 (pt) | 2018-01-30 |
SG11201610432UA (en) | 2017-01-27 |
IL249373A0 (en) | 2017-02-28 |
WO2015192127A3 (en) | 2016-03-17 |
CL2016003191A1 (es) | 2017-11-10 |
CN107074931A (zh) | 2017-08-18 |
PH12016502479A1 (en) | 2017-04-10 |
TW201625675A (zh) | 2016-07-16 |
KR20170035891A (ko) | 2017-03-31 |
AU2015274293A1 (en) | 2017-02-02 |
MX2016016281A (es) | 2017-03-31 |
TN2016000551A1 (en) | 2018-04-04 |
CA2952231A1 (en) | 2015-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |