CN104998273A - 能够与配体偶联的单甲基缬氨酸化合物 - Google Patents

能够与配体偶联的单甲基缬氨酸化合物 Download PDF

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Publication number
CN104998273A
CN104998273A CN201510435365.1A CN201510435365A CN104998273A CN 104998273 A CN104998273 A CN 104998273A CN 201510435365 A CN201510435365 A CN 201510435365A CN 104998273 A CN104998273 A CN 104998273A
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China
Prior art keywords
antibody
drug
cancer
antibodies
alkyl
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CN201510435365.1A
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English (en)
Chinese (zh)
Inventor
S·O·多罗尼纳
P·D·森特
B·E·托克
A·J·艾本斯
T·B·克林
P·波拉克斯
M·X·斯利沃科夫斯基
S·D·斯班舍
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Seagen Inc
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Seattle Genetics Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34916511&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104998273(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of CN104998273A publication Critical patent/CN104998273A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201510435365.1A 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物 Pending CN104998273A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US51853403P 2003-11-06 2003-11-06
US60/518,534 2003-11-06
US55711604P 2004-03-26 2004-03-26
US60/557,116 2004-03-26
US59889904P 2004-08-04 2004-08-04
US60/598,899 2004-08-04
US62245504P 2004-10-27 2004-10-27
US60/622,455 2004-10-27
CN200480039706.3A CN1938046B (zh) 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物

Related Parent Applications (1)

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Publication Number Publication Date
CN104998273A true CN104998273A (zh) 2015-10-28

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CN200480039706.3A Expired - Lifetime CN1938046B (zh) 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物
CN201510435365.1A Pending CN104998273A (zh) 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物
CN201710456121.0A Pending CN107213469A (zh) 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物
CN201310279259.XA Expired - Lifetime CN103394083B (zh) 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物

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CN201310279259.XA Expired - Lifetime CN103394083B (zh) 2003-11-06 2004-11-05 能够与配体偶联的单甲基缬氨酸化合物

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US (21) US7498298B2 (enExample)
EP (8) EP2489364B1 (enExample)
JP (4) JP5020636B2 (enExample)
KR (3) KR101192496B1 (enExample)
CN (4) CN1938046B (enExample)
AU (1) AU2004316290C1 (enExample)
BR (3) BRPI0416028B8 (enExample)
CA (3) CA2841741C (enExample)
DK (2) DK1725249T3 (enExample)
ES (6) ES2697327T3 (enExample)
IL (5) IL175247A (enExample)
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NZ (2) NZ547633A (enExample)
PL (2) PL2489364T3 (enExample)
PT (2) PT1725249E (enExample)
SG (3) SG149815A1 (enExample)
SI (2) SI1725249T1 (enExample)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109843919A (zh) * 2016-03-25 2019-06-04 西雅图基因公司 用于制备聚乙二醇化的药物-接头及其中间体的方法
CN110022938A (zh) * 2016-11-14 2019-07-16 千禧制药公司 抗cd30抗体药物缀合物的非成年人给药
CN110964043A (zh) * 2019-12-02 2020-04-07 广州中医药大学(广州中医药研究院) 一种瓜氨酸探针化合物及其应用

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JPS5990947A (ja) * 1982-11-16 1984-05-25 Matsushita Electronics Corp 半導体装置
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US20040141983A1 (en) * 1999-03-15 2004-07-22 Protein Design Labs, Inc. Compositions against cancer antigen LIV-1 and uses thereof
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