AR095882A1 - Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 - Google Patents
Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9Info
- Publication number
- AR095882A1 AR095882A1 ARP140101622A ARP140101622A AR095882A1 AR 095882 A1 AR095882 A1 AR 095882A1 AR P140101622 A ARP140101622 A AR P140101622A AR P140101622 A ARP140101622 A AR P140101622A AR 095882 A1 AR095882 A1 AR 095882A1
- Authority
- AR
- Argentina
- Prior art keywords
- combination therapy
- against human
- antibody combination
- human csf
- tlr9 agonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Terapia de combinación de anticuerpos contra CSF-1R (Receptor del factor 1 estimulante de colonias) humano con un antagonista de TLR9 (Receptores del tipo Toll). Anticuerpo, composición farmacéutica y método de tratamiento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13164695 | 2013-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR095882A1 true AR095882A1 (es) | 2015-11-18 |
Family
ID=48141840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140101622A AR095882A1 (es) | 2013-04-22 | 2014-04-16 | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
Country Status (13)
Country | Link |
---|---|
US (2) | US9192667B2 (es) |
EP (1) | EP2989125B1 (es) |
JP (1) | JP6506254B2 (es) |
KR (1) | KR20150132580A (es) |
CN (1) | CN104995213A (es) |
AR (1) | AR095882A1 (es) |
BR (1) | BR112015020911A2 (es) |
CA (1) | CA2898591A1 (es) |
HK (1) | HK1211305A1 (es) |
MX (1) | MX2015014500A (es) |
RU (1) | RU2015149929A (es) |
TW (1) | TW201444873A (es) |
WO (1) | WO2014173814A1 (es) |
Families Citing this family (30)
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DK2949670T3 (da) | 2009-12-10 | 2019-05-13 | Hoffmann La Roche | Antistoffer, der fortrinsvis binder humant ekstracellulært CSF1R-domæne 4 og anvendelse deraf |
EP2542587A1 (en) | 2010-03-05 | 2013-01-09 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r and uses thereof |
MX336682B (es) | 2010-03-05 | 2016-01-27 | Hoffmann La Roche | Anticuerpos contra csf-1r humanos y usos de los mismos. |
JP6242804B2 (ja) | 2011-12-15 | 2017-12-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ヒトcsf−1rに対する抗体及びその使用 |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
AU2014292926B2 (en) | 2013-07-25 | 2020-03-05 | Exicure Operating Company | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
WO2015048006A2 (en) | 2013-09-24 | 2015-04-02 | 3B Product Development, Llc | Protective cover and retractable lanyard |
TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
US10894061B2 (en) * | 2015-08-06 | 2021-01-19 | Regents Of The University Of Minnesota | Therapeutic methods involving modulating inflammasome activation of myeloid-derived suppressor cells |
EP3383173B1 (en) * | 2015-11-30 | 2020-11-25 | H. Hoffnabb-La Roche Ag | Generation of human macrophages in immunodeficient mice |
WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
KR20230149857A (ko) | 2016-07-07 | 2023-10-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
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JP7138094B2 (ja) * | 2016-08-25 | 2022-09-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | マクロファージ活性化剤と組み合わせた抗csf-1r抗体の間欠投与 |
AU2017348734A1 (en) * | 2016-10-28 | 2019-05-16 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
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WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
EP3720881A1 (en) | 2017-12-08 | 2020-10-14 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
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CN109053886B (zh) * | 2018-07-18 | 2020-07-28 | 博奥信生物技术(南京)有限公司 | 抗人csf-1r单克隆抗体及用途 |
CN109053888B (zh) * | 2018-07-18 | 2020-06-19 | 博奥信生物技术(南京)有限公司 | 一种抗人csf-1r单克隆抗体及其用途 |
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CN109364252B (zh) * | 2018-11-21 | 2021-09-28 | 南京大学 | 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用 |
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SG11202110843WA (en) * | 2019-03-29 | 2021-10-28 | Kolon Tissuegene Inc | CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-ß |
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AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
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-
2014
- 2014-04-16 AR ARP140101622A patent/AR095882A1/es unknown
- 2014-04-17 BR BR112015020911A patent/BR112015020911A2/pt not_active IP Right Cessation
- 2014-04-17 KR KR1020157030366A patent/KR20150132580A/ko not_active Application Discontinuation
- 2014-04-17 MX MX2015014500A patent/MX2015014500A/es unknown
- 2014-04-17 JP JP2016508177A patent/JP6506254B2/ja active Active
- 2014-04-17 CN CN201480007909.8A patent/CN104995213A/zh active Pending
- 2014-04-17 WO PCT/EP2014/057909 patent/WO2014173814A1/en active Application Filing
- 2014-04-17 EP EP14718115.0A patent/EP2989125B1/en active Active
- 2014-04-17 RU RU2015149929A patent/RU2015149929A/ru not_active Application Discontinuation
- 2014-04-17 CA CA2898591A patent/CA2898591A1/en not_active Abandoned
- 2014-04-21 US US14/257,480 patent/US9192667B2/en active Active
- 2014-04-21 TW TW103114424A patent/TW201444873A/zh unknown
-
2015
- 2015-10-16 US US14/885,910 patent/US20160220669A1/en not_active Abandoned
- 2015-12-09 HK HK15112150.4A patent/HK1211305A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20160220669A1 (en) | 2016-08-04 |
EP2989125B1 (en) | 2019-09-11 |
EP2989125A1 (en) | 2016-03-02 |
TW201444873A (zh) | 2014-12-01 |
BR112015020911A2 (pt) | 2017-10-10 |
US20140314771A1 (en) | 2014-10-23 |
MX2015014500A (es) | 2016-02-22 |
JP6506254B2 (ja) | 2019-04-24 |
HK1211305A1 (en) | 2016-05-20 |
CA2898591A1 (en) | 2014-10-30 |
RU2015149929A (ru) | 2017-05-25 |
JP2016516798A (ja) | 2016-06-09 |
WO2014173814A1 (en) | 2014-10-30 |
CN104995213A (zh) | 2015-10-21 |
KR20150132580A (ko) | 2015-11-25 |
US9192667B2 (en) | 2015-11-24 |
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