MX2015014500A - Terapia de combinacion de anticuerpos contra csf-1r y agonista de tlr9. - Google Patents
Terapia de combinacion de anticuerpos contra csf-1r y agonista de tlr9.Info
- Publication number
- MX2015014500A MX2015014500A MX2015014500A MX2015014500A MX2015014500A MX 2015014500 A MX2015014500 A MX 2015014500A MX 2015014500 A MX2015014500 A MX 2015014500A MX 2015014500 A MX2015014500 A MX 2015014500A MX 2015014500 A MX2015014500 A MX 2015014500A
- Authority
- MX
- Mexico
- Prior art keywords
- combination therapy
- antibodies against
- against human
- human csf
- tlr9 agonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con la terapia de combinación de anticuerpos contra el CSF-1R humano con un agonista de TLR9.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13164695 | 2013-04-22 | ||
PCT/EP2014/057909 WO2014173814A1 (en) | 2013-04-22 | 2014-04-17 | Combination therapy of antibodies against human csf-1r and tlr9 agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015014500A true MX2015014500A (es) | 2016-02-22 |
Family
ID=48141840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014500A MX2015014500A (es) | 2013-04-22 | 2014-04-17 | Terapia de combinacion de anticuerpos contra csf-1r y agonista de tlr9. |
Country Status (13)
Country | Link |
---|---|
US (2) | US9192667B2 (es) |
EP (1) | EP2989125B1 (es) |
JP (1) | JP6506254B2 (es) |
KR (1) | KR20150132580A (es) |
CN (1) | CN104995213A (es) |
AR (1) | AR095882A1 (es) |
BR (1) | BR112015020911A2 (es) |
CA (1) | CA2898591A1 (es) |
HK (1) | HK1211305A1 (es) |
MX (1) | MX2015014500A (es) |
RU (1) | RU2015149929A (es) |
TW (1) | TW201444873A (es) |
WO (1) | WO2014173814A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY159679A (en) | 2009-12-10 | 2017-01-13 | Hoffmann La Roche | Antibodies binding preferentially human csf1r extracellular domain 4 and their use |
MX2012010014A (es) | 2010-03-05 | 2012-09-21 | Hoffmann La Roche | Anticuerpos contra csf-1r humano y sus usos. |
KR101647871B1 (ko) | 2010-03-05 | 2016-08-11 | 에프. 호프만-라 로슈 아게 | 인간 csf-1r에 대한 항체 및 이의 용도 |
CN104159921B (zh) | 2011-12-15 | 2018-05-04 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
CN105579582A (zh) | 2013-07-25 | 2016-05-11 | 埃克西奎雷股份有限公司 | 用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体 |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
US9496911B2 (en) | 2013-09-24 | 2016-11-15 | 3B Product Development, Llc | Protective cover and retractable lanyard |
EP3164113B1 (en) | 2014-06-04 | 2019-03-27 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
CN108883131B (zh) * | 2015-08-06 | 2022-04-29 | 明尼苏达大学董事会 | 调节髓源性抑制细胞的炎性小体活化用于治疗GvHD或肿瘤 |
EP3383173B1 (en) * | 2015-11-30 | 2020-11-25 | H. Hoffnabb-La Roche Ag | Generation of human macrophages in immunodeficient mice |
EP3471754A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 antibodies |
KR20230149857A (ko) | 2016-07-07 | 2023-10-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
CN109790220A (zh) * | 2016-08-25 | 2019-05-21 | 豪夫迈·罗氏有限公司 | 与巨噬细胞激活剂组合的抗csf-1r抗体的间歇给药 |
AU2017348734A1 (en) * | 2016-10-28 | 2019-05-16 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
CN108728444A (zh) | 2017-04-18 | 2018-11-02 | 长春华普生物技术股份有限公司 | 免疫调节性多核苷酸及其应用 |
US20200071417A1 (en) | 2017-04-19 | 2020-03-05 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
US20200377571A1 (en) | 2017-12-08 | 2020-12-03 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
SG11202008432XA (en) * | 2018-03-02 | 2020-09-29 | Elicio Therapeutics Inc | Cpg amphiphiles and uses thereof |
CN109053886B (zh) * | 2018-07-18 | 2020-07-28 | 博奥信生物技术(南京)有限公司 | 抗人csf-1r单克隆抗体及用途 |
CN109053888B (zh) * | 2018-07-18 | 2020-06-19 | 博奥信生物技术(南京)有限公司 | 一种抗人csf-1r单克隆抗体及其用途 |
JP7465272B2 (ja) | 2018-09-27 | 2024-04-10 | マレンゴ・セラピューティクス,インコーポレーテッド | Csf1r/ccr2多特異性抗体 |
CN109364252B (zh) * | 2018-11-21 | 2021-09-28 | 南京大学 | 抑制ifn-i至arg1诱导通路在制备抗肿瘤药物组合物中的应用 |
WO2020124039A1 (en) * | 2018-12-13 | 2020-06-18 | Development Center For Biotechnology | Anti-human csf-1r antibody and uses thereof |
WO2020176789A1 (en) | 2019-02-28 | 2020-09-03 | Sqz Biotechnologies Company | Delivery of biomolecules to pbmcs to modify an immune response |
WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
CN113939323B (zh) * | 2019-03-29 | 2023-11-17 | 可隆组织基因有限公司 | 使用软骨细胞和TGF-β进行软骨再生 |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
EP0955365A3 (en) | 1992-06-09 | 2000-12-20 | Chiron Corporation | Crystallization of M-CSF |
EP0752248B1 (en) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
ES2258817T3 (es) | 1997-05-21 | 2006-09-01 | Biovation Limited | Metodo para la produccion de proteinas no inmunogenas. |
DK1019082T4 (da) | 1997-10-02 | 2008-10-27 | Max Planck Gesellschaft | Fremgangsmåde til moduleringen af neovaskularisering og/eller væksten af kollaterale arterier og/eller andre arterier fra forudeksisterende arteriolære forbindelser |
DE19935756A1 (de) | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
DE50002293D1 (de) | 1999-10-28 | 2003-06-26 | Hofbauer Reinhold | Verwendung von csf-1-inhibitoren |
AU767394C (en) | 1999-12-29 | 2005-04-21 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
AU2002360243A1 (en) | 2001-07-26 | 2003-05-06 | Tanox, Inc. | Agents that activate or inhibit toll-like receptor 9 |
US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
DE60332483D1 (de) | 2002-11-15 | 2010-06-17 | Novartis Vaccines & Diagnostic | Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust |
SG122973A1 (en) | 2003-10-30 | 2006-06-29 | Coley Pharm Gmbh | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
GB0325836D0 (en) | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
US20070264277A1 (en) | 2004-07-22 | 2007-11-15 | Dirk Behrens | Compositions and Methods of Use for Mgd-Csf in Disease Treatment |
TW200714290A (en) | 2005-03-08 | 2007-04-16 | Pharmacia & Upjohn Co Llc | Anti-M-CSF antibody compositions having reduced levels of endotoxin |
ES2542989T3 (es) | 2005-10-12 | 2015-08-13 | Idera Pharmaceuticals, Inc. | Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll |
US7470674B2 (en) | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
BRPI0619586A2 (pt) | 2005-12-09 | 2018-08-28 | Seattle Genetics Inc | método para o tratamento ou prevenção de um distúrbio associado com cd40 |
AU2006336242A1 (en) | 2005-12-20 | 2007-07-26 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications |
US20100016250A1 (en) | 2006-04-14 | 2010-01-21 | Kyowa Hakko Kirin Co., Ltd. | Toll-like receptor 9 agonists |
CN101610671A (zh) | 2006-12-12 | 2009-12-23 | 艾德拉药物股份有限公司 | 合成的tlr9激动剂 |
MX2009009530A (es) | 2007-03-07 | 2010-05-19 | Nventa Biopharmaceuticals Corp | Composiciones de acidos nucleicos cerrados bicatenarios. |
EP2821488B1 (en) | 2007-08-01 | 2016-07-27 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of TLR9 |
EA201591355A1 (ru) * | 2007-08-21 | 2016-04-29 | Амген Инк. | АНТИГЕНСВЯЗЫВАЮЩИЕ БЕЛКИ, СВЯЗЫВАЮЩИЕ c-fms ЧЕЛОВЕКА |
US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
KR101633520B1 (ko) | 2008-03-14 | 2016-06-24 | 트랜스진 에스.에이. | Csf-1r에 대한 항체 |
US20110044894A1 (en) | 2008-03-26 | 2011-02-24 | Cellerant Therapeutics, Inc. | Immunoglobulin and/or Toll-Like Receptor Proteins Associated with Myelogenous Haematological Proliferative Disorders and Uses Thereof |
CN108997498A (zh) | 2008-12-09 | 2018-12-14 | 霍夫曼-拉罗奇有限公司 | 抗-pd-l1抗体及它们用于增强t细胞功能的用途 |
JP2012516352A (ja) | 2009-01-30 | 2012-07-19 | イデラ ファーマシューティカルズ インコーポレイテッド | Tlr9の合成アゴニスト |
EP3279215B1 (en) | 2009-11-24 | 2020-02-12 | MedImmune Limited | Targeted binding agents against b7-h1 |
MY159679A (en) | 2009-12-10 | 2017-01-13 | Hoffmann La Roche | Antibodies binding preferentially human csf1r extracellular domain 4 and their use |
KR101647871B1 (ko) | 2010-03-05 | 2016-08-11 | 에프. 호프만-라 로슈 아게 | 인간 csf-1r에 대한 항체 및 이의 용도 |
MX2012010014A (es) | 2010-03-05 | 2012-09-21 | Hoffmann La Roche | Anticuerpos contra csf-1r humano y sus usos. |
TWI426920B (zh) | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | 雙專一性、雙價抗-vegf/抗-ang-2抗體 |
AR080698A1 (es) * | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
TR201900368T4 (tr) | 2010-05-04 | 2019-02-21 | Five Prime Therapeutics Inc | Csf1r'ye bağlanan antikorlar. |
JP5798404B2 (ja) | 2010-08-31 | 2015-10-21 | 日東電工株式会社 | 極板保護用粘着テープ |
CN107012149A (zh) * | 2010-11-19 | 2017-08-04 | 艾德拉药物股份有限公司 | 调控基于toll‑样受体的免疫应答的免疫调节寡核苷酸(iro)化合物 |
GB201021867D0 (en) | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
FR2975600B1 (fr) * | 2011-05-24 | 2013-07-05 | Assist Publ Hopitaux De Paris | Agents pour le traitement de tumeurs |
DK2734547T3 (en) | 2011-07-18 | 2017-04-03 | Univ Melbourne | USE OF C-FMS ANTIBODIES |
EP2768862A2 (en) | 2011-10-21 | 2014-08-27 | Transgene SA | Modulation of macrophage activation |
KR101981873B1 (ko) | 2011-11-28 | 2019-05-23 | 메르크 파텐트 게엠베하 | 항-pd-l1 항체 및 그의 용도 |
CN104159921B (zh) | 2011-12-15 | 2018-05-04 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
MX2014008961A (es) | 2012-02-06 | 2014-10-14 | Genentech Inc | Composiciones y metodos para utilizar inhibidores de csf1r. |
AR090263A1 (es) * | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
CA2871445C (en) | 2012-05-11 | 2020-07-07 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
AU2013343556B2 (en) | 2012-11-09 | 2018-06-28 | Transgene Sa | Modulation of monocytes, or precursors thereof, differentiation |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
-
2014
- 2014-04-16 AR ARP140101622A patent/AR095882A1/es unknown
- 2014-04-17 CA CA2898591A patent/CA2898591A1/en not_active Abandoned
- 2014-04-17 JP JP2016508177A patent/JP6506254B2/ja active Active
- 2014-04-17 EP EP14718115.0A patent/EP2989125B1/en active Active
- 2014-04-17 CN CN201480007909.8A patent/CN104995213A/zh active Pending
- 2014-04-17 RU RU2015149929A patent/RU2015149929A/ru not_active Application Discontinuation
- 2014-04-17 MX MX2015014500A patent/MX2015014500A/es unknown
- 2014-04-17 BR BR112015020911A patent/BR112015020911A2/pt not_active IP Right Cessation
- 2014-04-17 WO PCT/EP2014/057909 patent/WO2014173814A1/en active Application Filing
- 2014-04-17 KR KR1020157030366A patent/KR20150132580A/ko not_active Application Discontinuation
- 2014-04-21 US US14/257,480 patent/US9192667B2/en active Active
- 2014-04-21 TW TW103114424A patent/TW201444873A/zh unknown
-
2015
- 2015-10-16 US US14/885,910 patent/US20160220669A1/en not_active Abandoned
- 2015-12-09 HK HK15112150.4A patent/HK1211305A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20160220669A1 (en) | 2016-08-04 |
BR112015020911A2 (pt) | 2017-10-10 |
CA2898591A1 (en) | 2014-10-30 |
AR095882A1 (es) | 2015-11-18 |
KR20150132580A (ko) | 2015-11-25 |
JP6506254B2 (ja) | 2019-04-24 |
EP2989125A1 (en) | 2016-03-02 |
US9192667B2 (en) | 2015-11-24 |
WO2014173814A1 (en) | 2014-10-30 |
CN104995213A (zh) | 2015-10-21 |
RU2015149929A (ru) | 2017-05-25 |
US20140314771A1 (en) | 2014-10-23 |
EP2989125B1 (en) | 2019-09-11 |
HK1211305A1 (en) | 2016-05-20 |
TW201444873A (zh) | 2014-12-01 |
JP2016516798A (ja) | 2016-06-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2015014500A (es) | Terapia de combinacion de anticuerpos contra csf-1r y agonista de tlr9. | |
MX2016003129A (es) | Terapia de combinacion de anticuerpos contra el csf-1r humano y anticuerpos contralel pd-l1 humano. | |
PH12015501954A1 (en) | Anti-b7-h4 antibodies and immunoconjugates | |
PH12016501143A1 (en) | Anti-cd33 antibodies and immunoconjugates | |
MX2020002289A (es) | Anticuerpos anti-alfa-sinucleina y metodos de uso. | |
PH12016500482A1 (en) | Combination therapy with an anti-ang2 antibody and a cd40 agonist | |
MY176285A (en) | Anti-fcrh5 antibodies | |
PH12015502565A1 (en) | Anti-transferrin receptor antibodies and methods of use | |
MX2020010141A (es) | Anticuerpos anti-factor del complemento c1q y uso de los mismos. | |
AU360562S (en) | Band attachment | |
AU360563S (en) | Band attachment | |
AU360564S (en) | Band attachment | |
MX2015012326A (es) | Anticuerpos anti-crth2 y su uso. | |
PH12014502132A1 (en) | Anti-lgr5 antibodies and immunoconjugates | |
PH12015501071A1 (en) | Combination therapy of anti-her3 antibodies | |
PH12014501605A1 (en) | Anti-lrp5 antibodies and methods of use | |
IN2014DE01038A (es) | ||
IN2013DE00266A (es) | ||
AU352731S (en) | Safety apparatus | |
MX2015010789A (es) | Anticuerpos anti-pcsm. | |
AU357123S (en) | Animal trap | |
AU356775S (en) | Chair | |
AU356698S (en) | Chair | |
AU351525S (en) | Light fitting | |
AU351524S (en) | Light fitting |