BR112015020911A2 - anticorpo, uso de uma combinação e método de tratamento - Google Patents

anticorpo, uso de uma combinação e método de tratamento

Info

Publication number
BR112015020911A2
BR112015020911A2 BR112015020911A BR112015020911A BR112015020911A2 BR 112015020911 A2 BR112015020911 A2 BR 112015020911A2 BR 112015020911 A BR112015020911 A BR 112015020911A BR 112015020911 A BR112015020911 A BR 112015020911A BR 112015020911 A2 BR112015020911 A2 BR 112015020911A2
Authority
BR
Brazil
Prior art keywords
combination
antibody
treatment method
treatment
abstract
Prior art date
Application number
BR112015020911A
Other languages
English (en)
Inventor
Ries Carola
Ruettinger Dominik
Wartha Katharina
Hoves Sabine
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015020911A2 publication Critical patent/BR112015020911A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

resumo “anticorpo, uso de uma combinação e método de tratamento” a presente invenção refere-se à terapia de combinação de anticorpos contra csf-1r humano com agonista de tlr9.
BR112015020911A 2013-04-22 2014-04-17 anticorpo, uso de uma combinação e método de tratamento BR112015020911A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13164695 2013-04-22
PCT/EP2014/057909 WO2014173814A1 (en) 2013-04-22 2014-04-17 Combination therapy of antibodies against human csf-1r and tlr9 agonist

Publications (1)

Publication Number Publication Date
BR112015020911A2 true BR112015020911A2 (pt) 2017-10-10

Family

ID=48141840

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015020911A BR112015020911A2 (pt) 2013-04-22 2014-04-17 anticorpo, uso de uma combinação e método de tratamento

Country Status (13)

Country Link
US (2) US9192667B2 (pt)
EP (1) EP2989125B1 (pt)
JP (1) JP6506254B2 (pt)
KR (1) KR20150132580A (pt)
CN (1) CN104995213A (pt)
AR (1) AR095882A1 (pt)
BR (1) BR112015020911A2 (pt)
CA (1) CA2898591A1 (pt)
HK (1) HK1211305A1 (pt)
MX (1) MX2015014500A (pt)
RU (1) RU2015149929A (pt)
TW (1) TW201444873A (pt)
WO (1) WO2014173814A1 (pt)

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Also Published As

Publication number Publication date
TW201444873A (zh) 2014-12-01
JP2016516798A (ja) 2016-06-09
EP2989125A1 (en) 2016-03-02
US20160220669A1 (en) 2016-08-04
US9192667B2 (en) 2015-11-24
MX2015014500A (es) 2016-02-22
CA2898591A1 (en) 2014-10-30
CN104995213A (zh) 2015-10-21
EP2989125B1 (en) 2019-09-11
RU2015149929A (ru) 2017-05-25
AR095882A1 (es) 2015-11-18
US20140314771A1 (en) 2014-10-23
HK1211305A1 (en) 2016-05-20
JP6506254B2 (ja) 2019-04-24
WO2014173814A1 (en) 2014-10-30
KR20150132580A (ko) 2015-11-25

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