EP2989125B1 - Combination therapy of antibodies against human csf-1r and tlr9 agonist - Google Patents

Combination therapy of antibodies against human csf-1r and tlr9 agonist Download PDF

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Publication number
EP2989125B1
EP2989125B1 EP14718115.0A EP14718115A EP2989125B1 EP 2989125 B1 EP2989125 B1 EP 2989125B1 EP 14718115 A EP14718115 A EP 14718115A EP 2989125 B1 EP2989125 B1 EP 2989125B1
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EP
European Patent Office
Prior art keywords
seq
csf
chain variable
variable domain
region
Prior art date
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EP14718115.0A
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German (de)
English (en)
French (fr)
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EP2989125A1 (en
Inventor
Sabine HOVES
Carola Ries
Dominik Ruettinger
Katharina Wartha
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of EP2989125A1 publication Critical patent/EP2989125A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046Stomach, Intestines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
EP14718115.0A 2013-04-22 2014-04-17 Combination therapy of antibodies against human csf-1r and tlr9 agonist Active EP2989125B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14718115.0A EP2989125B1 (en) 2013-04-22 2014-04-17 Combination therapy of antibodies against human csf-1r and tlr9 agonist

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13164695 2013-04-22
EP14718115.0A EP2989125B1 (en) 2013-04-22 2014-04-17 Combination therapy of antibodies against human csf-1r and tlr9 agonist
PCT/EP2014/057909 WO2014173814A1 (en) 2013-04-22 2014-04-17 Combination therapy of antibodies against human csf-1r and tlr9 agonist

Publications (2)

Publication Number Publication Date
EP2989125A1 EP2989125A1 (en) 2016-03-02
EP2989125B1 true EP2989125B1 (en) 2019-09-11

Family

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EP14718115.0A Active EP2989125B1 (en) 2013-04-22 2014-04-17 Combination therapy of antibodies against human csf-1r and tlr9 agonist

Country Status (13)

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US (2) US9192667B2 (pt)
EP (1) EP2989125B1 (pt)
JP (1) JP6506254B2 (pt)
KR (1) KR20150132580A (pt)
CN (1) CN104995213A (pt)
AR (1) AR095882A1 (pt)
BR (1) BR112015020911A2 (pt)
CA (1) CA2898591A1 (pt)
HK (1) HK1211305A1 (pt)
MX (1) MX2015014500A (pt)
RU (1) RU2015149929A (pt)
TW (1) TW201444873A (pt)
WO (1) WO2014173814A1 (pt)

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Also Published As

Publication number Publication date
HK1211305A1 (en) 2016-05-20
CA2898591A1 (en) 2014-10-30
US20160220669A1 (en) 2016-08-04
AR095882A1 (es) 2015-11-18
JP2016516798A (ja) 2016-06-09
EP2989125A1 (en) 2016-03-02
WO2014173814A1 (en) 2014-10-30
CN104995213A (zh) 2015-10-21
MX2015014500A (es) 2016-02-22
US20140314771A1 (en) 2014-10-23
RU2015149929A (ru) 2017-05-25
TW201444873A (zh) 2014-12-01
BR112015020911A2 (pt) 2017-10-10
JP6506254B2 (ja) 2019-04-24
KR20150132580A (ko) 2015-11-25
US9192667B2 (en) 2015-11-24

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