BR112015020911A2 - antibody, use of a combination and treatment method - Google Patents
antibody, use of a combination and treatment methodInfo
- Publication number
- BR112015020911A2 BR112015020911A2 BR112015020911A BR112015020911A BR112015020911A2 BR 112015020911 A2 BR112015020911 A2 BR 112015020911A2 BR 112015020911 A BR112015020911 A BR 112015020911A BR 112015020911 A BR112015020911 A BR 112015020911A BR 112015020911 A2 BR112015020911 A2 BR 112015020911A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- antibody
- treatment method
- treatment
- abstract
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
resumo anticorpo, uso de uma combinação e método de tratamento a presente invenção refere-se à terapia de combinação de anticorpos contra csf-1r humano com agonista de tlr9.abstract "antibody, use of a combination and method of treatment" the present invention relates to the combination therapy of antibodies against human csf-1r with tlr9 agonist.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13164695 | 2013-04-22 | ||
PCT/EP2014/057909 WO2014173814A1 (en) | 2013-04-22 | 2014-04-17 | Combination therapy of antibodies against human csf-1r and tlr9 agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015020911A2 true BR112015020911A2 (en) | 2017-10-10 |
Family
ID=48141840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015020911A BR112015020911A2 (en) | 2013-04-22 | 2014-04-17 | antibody, use of a combination and treatment method |
Country Status (13)
Country | Link |
---|---|
US (2) | US9192667B2 (en) |
EP (1) | EP2989125B1 (en) |
JP (1) | JP6506254B2 (en) |
KR (1) | KR20150132580A (en) |
CN (1) | CN104995213A (en) |
AR (1) | AR095882A1 (en) |
BR (1) | BR112015020911A2 (en) |
CA (1) | CA2898591A1 (en) |
HK (1) | HK1211305A1 (en) |
MX (1) | MX2015014500A (en) |
RU (1) | RU2015149929A (en) |
TW (1) | TW201444873A (en) |
WO (1) | WO2014173814A1 (en) |
Families Citing this family (30)
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ES2557454T3 (en) | 2009-12-10 | 2016-01-26 | F. Hoffmann-La Roche Ag | Antibodies that bind to the extracellular domain 4 of human CSF1R and its use |
EP2542587A1 (en) | 2010-03-05 | 2013-01-09 | F. Hoffmann-La Roche AG | Antibodies against human csf-1r and uses thereof |
MX336682B (en) | 2010-03-05 | 2016-01-27 | Hoffmann La Roche | Antibodies against human csf-1r and uses thereof. |
MX356337B (en) | 2011-12-15 | 2018-05-23 | Hoffmann La Roche | Antibodies against human csf-1r and uses thereof. |
AR095882A1 (en) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST |
CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
AR097584A1 (en) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R AND ANTIBODIES AGAINST HUMAN PD-L1 |
WO2015048006A2 (en) | 2013-09-24 | 2015-04-02 | 3B Product Development, Llc | Protective cover and retractable lanyard |
EP3508198A1 (en) | 2014-06-04 | 2019-07-10 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
EP3682889B1 (en) * | 2015-08-06 | 2023-02-01 | Regents of the University of Minnesota | Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd |
EP3383173B1 (en) * | 2015-11-30 | 2020-11-25 | H. Hoffnabb-La Roche Ag | Generation of human macrophages in immunodeficient mice |
KR102531889B1 (en) | 2016-06-20 | 2023-05-17 | 키맵 리미티드 | Anti-PD-L1 and IL-2 cytokines |
CN109843327B (en) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | Antibody adjuvant conjugates |
WO2018036852A1 (en) | 2016-08-25 | 2018-03-01 | F. Hoffmann-La Roche Ag | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
BR112019008335A2 (en) * | 2016-10-28 | 2020-01-28 | Toray Industries | conjugate of an antibody, pharmaceutical composition and method for the treatment and / or prevention of cancer |
EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
CN108728444A (en) | 2017-04-18 | 2018-11-02 | 长春华普生物技术股份有限公司 | Immunoregulation polynucleotide and its application |
AU2018256406A1 (en) | 2017-04-19 | 2019-10-17 | Marengo Therapeutics, Inc. | Multispecific molecules and uses thereof |
US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
US20200377571A1 (en) | 2017-12-08 | 2020-12-03 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
BR112020017778A2 (en) * | 2018-03-02 | 2021-01-05 | Elicio Therapeutics, Inc. | CPG AMPHIPHILS AND USES THEREOF |
CN109053888B (en) * | 2018-07-18 | 2020-06-19 | 博奥信生物技术(南京)有限公司 | Anti-human CSF-1R monoclonal antibody and application thereof |
CN109053886B (en) * | 2018-07-18 | 2020-07-28 | 博奥信生物技术(南京)有限公司 | Anti-human CSF-1R monoclonal antibody and application |
AU2019346645A1 (en) | 2018-09-27 | 2021-04-29 | Marengo Therapeutics, Inc. | CSF1R/CCR2 multispecific antibodies |
CN109364252B (en) * | 2018-11-21 | 2021-09-28 | 南京大学 | Application of inhibiting IFN-I to ARG1 induction pathway in preparation of anti-tumor pharmaceutical composition |
WO2020124039A1 (en) * | 2018-12-13 | 2020-06-18 | Development Center For Biotechnology | Anti-human csf-1r antibody and uses thereof |
KR20210134353A (en) | 2019-02-28 | 2021-11-09 | 에스큐지 바이오테크놀로지스 컴퍼니 | Delivery of Biomolecules to PBMCs to Modify the Immune Response |
KR20220004634A (en) | 2019-03-15 | 2022-01-11 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | Immunoconjugates targeting HER2 |
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-
2014
- 2014-04-16 AR ARP140101622A patent/AR095882A1/en unknown
- 2014-04-17 WO PCT/EP2014/057909 patent/WO2014173814A1/en active Application Filing
- 2014-04-17 RU RU2015149929A patent/RU2015149929A/en not_active Application Discontinuation
- 2014-04-17 JP JP2016508177A patent/JP6506254B2/en active Active
- 2014-04-17 MX MX2015014500A patent/MX2015014500A/en unknown
- 2014-04-17 CA CA2898591A patent/CA2898591A1/en not_active Abandoned
- 2014-04-17 CN CN201480007909.8A patent/CN104995213A/en active Pending
- 2014-04-17 BR BR112015020911A patent/BR112015020911A2/en not_active IP Right Cessation
- 2014-04-17 KR KR1020157030366A patent/KR20150132580A/en not_active Application Discontinuation
- 2014-04-17 EP EP14718115.0A patent/EP2989125B1/en active Active
- 2014-04-21 US US14/257,480 patent/US9192667B2/en active Active
- 2014-04-21 TW TW103114424A patent/TW201444873A/en unknown
-
2015
- 2015-10-16 US US14/885,910 patent/US20160220669A1/en not_active Abandoned
- 2015-12-09 HK HK15112150.4A patent/HK1211305A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201444873A (en) | 2014-12-01 |
JP2016516798A (en) | 2016-06-09 |
US20160220669A1 (en) | 2016-08-04 |
AR095882A1 (en) | 2015-11-18 |
MX2015014500A (en) | 2016-02-22 |
CN104995213A (en) | 2015-10-21 |
CA2898591A1 (en) | 2014-10-30 |
EP2989125B1 (en) | 2019-09-11 |
JP6506254B2 (en) | 2019-04-24 |
EP2989125A1 (en) | 2016-03-02 |
HK1211305A1 (en) | 2016-05-20 |
KR20150132580A (en) | 2015-11-25 |
WO2014173814A1 (en) | 2014-10-30 |
RU2015149929A (en) | 2017-05-25 |
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US9192667B2 (en) | 2015-11-24 |
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