MX2009009530A - Composiciones de acidos nucleicos cerrados bicatenarios. - Google Patents
Composiciones de acidos nucleicos cerrados bicatenarios.Info
- Publication number
- MX2009009530A MX2009009530A MX2009009530A MX2009009530A MX2009009530A MX 2009009530 A MX2009009530 A MX 2009009530A MX 2009009530 A MX2009009530 A MX 2009009530A MX 2009009530 A MX2009009530 A MX 2009009530A MX 2009009530 A MX2009009530 A MX 2009009530A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- double
- locked nucleic
- acid compositions
- stranded locked
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 5
- 108020004707 nucleic acids Proteins 0.000 title abstract 5
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Abstract
Se proporcionan agentes inmunoestimuladores, incluyendo ácidos nucleicos que tienen uno o más de un nucleótido ce ácido nucleico cerrado (LNA). Los ácidos nucleicos pueden comprender además porciones CpG. Los ácidos nucleicos pueden ser bicatenarios, y pueden comprender dsRNA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90546107P | 2007-03-07 | 2007-03-07 | |
US95027107P | 2007-07-17 | 2007-07-17 | |
PCT/CA2008/000473 WO2008106803A1 (en) | 2007-03-07 | 2008-03-07 | Double-stranded locked nucleic acid compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009009530A true MX2009009530A (es) | 2010-05-19 |
Family
ID=39737757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009009530A MX2009009530A (es) | 2007-03-07 | 2008-03-07 | Composiciones de acidos nucleicos cerrados bicatenarios. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090041809A1 (es) |
EP (1) | EP2125853A1 (es) |
JP (1) | JP2010519915A (es) |
KR (1) | KR20100051041A (es) |
CN (1) | CN101687900A (es) |
AU (1) | AU2008222523A1 (es) |
BR (1) | BRPI0808442A2 (es) |
CA (1) | CA2680060A1 (es) |
MX (1) | MX2009009530A (es) |
WO (1) | WO2008106803A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0228540D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Novel compositions |
WO2009149470A1 (en) | 2008-06-06 | 2009-12-10 | Aurora Biofuels, Inc. | Vcp-based vectors for algal cell transformation |
BRPI0914224A2 (pt) | 2008-06-19 | 2019-09-24 | Variation Biotechnologies Inc | composições e métodos para tratar a gripe |
SG10201801667YA (en) | 2009-03-19 | 2018-03-28 | Emd Millipore Corp | Removal of microorganisms from fluid samples using nanofiber filtration media |
US20110097418A1 (en) * | 2009-05-29 | 2011-04-28 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
US9029137B2 (en) | 2009-06-08 | 2015-05-12 | Aurora Algae, Inc. | ACP promoter |
US8865468B2 (en) | 2009-10-19 | 2014-10-21 | Aurora Algae, Inc. | Homologous recombination in an algal nuclear genome |
US8809046B2 (en) | 2011-04-28 | 2014-08-19 | Aurora Algae, Inc. | Algal elongases |
CA2767392C (en) | 2009-07-06 | 2017-03-14 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
WO2011011463A2 (en) * | 2009-07-20 | 2011-01-27 | Aurora Biofuels, Inc. | Manipulation of an alternative respiratory pathway in photo-autotrophs |
CA2776386C (en) | 2009-10-02 | 2018-02-27 | The Trustees Of Columbia University In The City Of New York | Piscine reovirus immunogenic compositions |
US8846388B2 (en) * | 2009-10-16 | 2014-09-30 | Zoetis Llc | Infectious clones of torque teno virus |
WO2012027017A2 (en) * | 2010-06-25 | 2012-03-01 | Idera Pharmaceuticals, Inc. | Novel agonists of toll-like receptor 3 and methods of their use |
MX342138B (es) | 2010-07-06 | 2016-09-14 | Variation Biotechnologies Inc | Composiciones y metodos para el tratamiento de influenza. |
ES2774949T3 (es) | 2010-08-10 | 2020-07-23 | Emd Millipore Corp | Método para la eliminación de retrovirus |
WO2012040127A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
EP2655612B1 (en) | 2010-12-23 | 2017-07-19 | Shell Internationale Research Maatschappij B.V. | Gene disruptants producing fatty acyl-coa derivatives |
WO2012097347A1 (en) | 2011-01-13 | 2012-07-19 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
CA2862864C (en) | 2011-01-13 | 2018-12-11 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
US8722359B2 (en) | 2011-01-21 | 2014-05-13 | Aurora Algae, Inc. | Genes for enhanced lipid metabolism for accumulation of lipids |
KR101551298B1 (ko) | 2011-04-01 | 2015-09-08 | 이엠디 밀리포어 코포레이션 | 나노섬유 함유 복합재료 구조 |
AU2012249377A1 (en) | 2011-04-28 | 2013-11-14 | Aurora Algae, Inc. | Algal desaturases |
WO2013096680A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
CN104302323A (zh) | 2012-01-12 | 2015-01-21 | 变异生物技术公司 | 用于治疗病毒感染的组合物和方法 |
AU2013213345A1 (en) | 2012-01-27 | 2014-08-28 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
EP2828277A1 (en) | 2012-03-21 | 2015-01-28 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
US9157101B2 (en) * | 2012-12-21 | 2015-10-13 | Algenol Biotech LLC | Cyanobacterium sp. for production of compounds |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
EP3835419A1 (en) | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
WO2016061131A1 (en) | 2014-10-14 | 2016-04-21 | The J. David Gladstone Institutes | Compositions and methods for reactivating latent immunodeficiency virus |
WO2016105483A1 (en) | 2014-12-23 | 2016-06-30 | Algenol Biotech LLC | Methods for increasing the stability of production of compounds in microbial host cells |
WO2016167871A1 (en) | 2015-04-17 | 2016-10-20 | Emd Millipore Corporation | Method of purifying a biological materia of interest in a sample using nanofiber ultrafiltration membranes operated in tangential flow filtration mode |
US10392607B2 (en) | 2015-06-03 | 2019-08-27 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
US10138489B2 (en) | 2016-10-20 | 2018-11-27 | Algenol Biotech LLC | Cyanobacterial strains capable of utilizing phosphite |
EP3690030A4 (en) | 2017-09-28 | 2021-06-23 | Industry-Academic Cooperation Foundation, Yonsei University | METHOD FOR MANUFACTURING MYELOID-DERIVED SUPPRESSOR CELLS, SUPPRESSOR CELLS MANUFACTURED FROM MYEOLID AND USES THEREOF |
WO2019211492A1 (en) * | 2018-05-04 | 2019-11-07 | Tollys | Tlr3 ligands that activate both epithelial and myeloid cells |
EP3935156A4 (en) | 2019-03-07 | 2022-12-28 | The Regents of The University of California | CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE |
BR112021026720A2 (pt) * | 2019-07-02 | 2022-02-15 | Na Vaccine Inst | Rna heteroestruturado, dsrna homogêneo, composição farmacêutica, agente farmacêutico homogêneo e agente terapêutico para o câncer |
US20230302158A1 (en) * | 2020-08-14 | 2023-09-28 | Allen Institute | Artificial expression constructs for modulating gene expression in striatal neurons |
TW202308629A (zh) | 2021-04-28 | 2023-03-01 | 法商Enyo製藥公司 | 使用fxr激動劑作為組合治療以增強tlr3激動劑之療效 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3692899A (en) * | 1969-12-17 | 1972-09-19 | Us Health Education & Welfare | Inhibition of transplanted tumor growth by polyinosinic-polycytidylic acid in mice |
US3952097A (en) * | 1974-09-27 | 1976-04-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
US4024241A (en) * | 1974-09-27 | 1977-05-17 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
US4349538A (en) * | 1979-12-07 | 1982-09-14 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6194388B1 (en) * | 1994-07-15 | 2001-02-27 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US7157089B1 (en) * | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
JP3756313B2 (ja) * | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
CA2203843C (en) * | 1997-04-28 | 2013-07-23 | Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence | Liposome-encapsulated poly iclc |
US6794499B2 (en) * | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
US6083482A (en) * | 1999-05-11 | 2000-07-04 | Icn Pharmaceuticals, Inc. | Conformationally locked nucleosides and oligonucleotides |
AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
EP1474432A1 (en) * | 2002-02-04 | 2004-11-10 | Biomira Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
AU2003248791A1 (en) * | 2002-07-03 | 2005-11-09 | Oncovir, Inc. | Method for preparation of poly-iclc and uses thereof |
GB0228540D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Novel compositions |
CA2542232A1 (en) * | 2003-06-09 | 2005-01-20 | Alnylam Pharmaceuticals, Inc. | Method for treating neurodegenerative disease by inhibiting alpha-synuclein |
WO2006054129A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
US7834064B2 (en) * | 2005-01-03 | 2010-11-16 | Andres Mario Salazar | Clinical method for the immunomodulatory and vaccine adjuvant use of poly-ICLC and other dsRNAs |
EP1941058A4 (en) * | 2005-10-27 | 2010-01-20 | Rosetta Inpharmatics Llc | AMPLIFICATION OF NUCLEIC ACIDS USING NON-RANDOM PRIMERS |
JP2009513716A (ja) * | 2005-11-01 | 2009-04-02 | アルナイラム ファーマシューティカルズ インコーポレイテッド | RNAiによるインフルエンザウイルス複製の抑制 |
-
2008
- 2008-03-07 CN CN200880014144A patent/CN101687900A/zh active Pending
- 2008-03-07 WO PCT/CA2008/000473 patent/WO2008106803A1/en active Application Filing
- 2008-03-07 BR BRPI0808442-4A patent/BRPI0808442A2/pt not_active IP Right Cessation
- 2008-03-07 MX MX2009009530A patent/MX2009009530A/es not_active Application Discontinuation
- 2008-03-07 KR KR1020097020608A patent/KR20100051041A/ko not_active Application Discontinuation
- 2008-03-07 AU AU2008222523A patent/AU2008222523A1/en not_active Abandoned
- 2008-03-07 JP JP2009552038A patent/JP2010519915A/ja not_active Abandoned
- 2008-03-07 CA CA002680060A patent/CA2680060A1/en not_active Abandoned
- 2008-03-07 EP EP08733577A patent/EP2125853A1/en not_active Withdrawn
- 2008-03-07 US US12/044,895 patent/US20090041809A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20100051041A (ko) | 2010-05-14 |
US20090041809A1 (en) | 2009-02-12 |
WO2008106803A1 (en) | 2008-09-12 |
EP2125853A1 (en) | 2009-12-02 |
CN101687900A (zh) | 2010-03-31 |
CA2680060A1 (en) | 2008-09-12 |
JP2010519915A (ja) | 2010-06-10 |
BRPI0808442A2 (pt) | 2014-08-05 |
AU2008222523A1 (en) | 2008-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009009530A (es) | Composiciones de acidos nucleicos cerrados bicatenarios. | |
WO2006002038A3 (en) | Immunostimulatory oligonucleotide multimers | |
WO2008086381A3 (en) | Isothermal dna amplification | |
ATE542922T1 (de) | 2'-terminator-assoziierte pyrophosphorolyse- aktivierte polymerisierung | |
WO2010048585A3 (en) | Oligomeric compounds and methods | |
WO2008087561A8 (en) | Methods and compositions for modulating the sirna and rna-directed-dna methylation pathways | |
CR20140422A (es) | Composiciones de enzima digestiva estable | |
WO2006086673A3 (en) | Nucleotide compositions and uses thereof | |
IL205880A0 (en) | Aminoglycoside analogs, compositions comprising the same and uses thereof | |
WO2007064945A3 (en) | Cancer therapies and pharmaceutical compositions used therein | |
EP1941058A4 (en) | AMPLIFICATION OF NUCLEIC ACIDS USING NON-RANDOM PRIMERS | |
WO2007062160A8 (en) | Methods and compositions for sequencing a nucleic acid | |
WO2009147537A3 (en) | Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers | |
WO2007042554A3 (en) | Methods and compositions for treating immune disorders | |
WO2007134181A3 (en) | 5'-modified bicyclic nucleic acid analogs | |
IL190153A0 (en) | Immunostimulatory single-stranded ribonucleic acid with phosphodiester backbone | |
MX2010004109A (es) | 2'-fluoro-2'-desoxitetrahidrouridinas como inhibidores de citidina desaminasa. | |
WO2010054154A3 (en) | Bifidobacteria crispr sequences | |
IL204621A0 (en) | Bicyclic - ?? - amino acid derivatives, compositions comprising the same and uses thereof | |
WO2018146557A3 (en) | Long double-stranded rna for rna interference | |
WO2010077740A3 (en) | Novel antiviral compounds, compositions, and methods of use | |
WO2006072612A3 (en) | Triazolophthalazines as pde2- inhibitors | |
WO2009108217A3 (en) | Compositions comprising k-ras sirna and methods of use | |
MX2009012482A (es) | Oligonucleotidos de clase a con potencia inmunoestimuladora. | |
WO2009077471A3 (de) | Azolylmethyloxirane, ihre verwendung sowie sie enthaltende mittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |