MX2010004109A - 2'-fluoro-2'-desoxitetrahidrouridinas como inhibidores de citidina desaminasa. - Google Patents

2'-fluoro-2'-desoxitetrahidrouridinas como inhibidores de citidina desaminasa.

Info

Publication number
MX2010004109A
MX2010004109A MX2010004109A MX2010004109A MX2010004109A MX 2010004109 A MX2010004109 A MX 2010004109A MX 2010004109 A MX2010004109 A MX 2010004109A MX 2010004109 A MX2010004109 A MX 2010004109A MX 2010004109 A MX2010004109 A MX 2010004109A
Authority
MX
Mexico
Prior art keywords
deoxytetrahydrouridines
flu0r0
cytidine deaminase
deaminase inhibitors
compounds
Prior art date
Application number
MX2010004109A
Other languages
English (en)
Inventor
Gregory S Hamilton
Takashi Tsukamoto
Dana V Ferraris
Bridget Duvall
Rena Lapidus
Original Assignee
Eisai Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Inc filed Critical Eisai Inc
Publication of MX2010004109A publication Critical patent/MX2010004109A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención provee determinados compuestos derivados de tetrahidrouridina, composiciones farmacéuticas y kits que comprenden tales compuestos y métodos de preparación y uso de tales compuestos.
MX2010004109A 2007-10-16 2008-10-16 2'-fluoro-2'-desoxitetrahidrouridinas como inhibidores de citidina desaminasa. MX2010004109A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98039707P 2007-10-16 2007-10-16
PCT/US2008/080163 WO2009052287A1 (en) 2007-10-16 2008-10-16 2 ' -flu0r0-2 ' -deoxytetrahydrouridines as cytidine deaminase inhibitors

Publications (1)

Publication Number Publication Date
MX2010004109A true MX2010004109A (es) 2010-08-10

Family

ID=40251685

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004109A MX2010004109A (es) 2007-10-16 2008-10-16 2'-fluoro-2'-desoxitetrahidrouridinas como inhibidores de citidina desaminasa.

Country Status (39)

Country Link
US (4) US8268800B2 (es)
EP (2) EP2447272B1 (es)
JP (2) JP5496899B2 (es)
KR (1) KR101543049B1 (es)
CN (1) CN101827856B (es)
AT (1) ATE548374T1 (es)
BR (1) BRPI0818672B8 (es)
CA (1) CA2702274C (es)
CO (1) CO6270330A2 (es)
CR (1) CR11427A (es)
CY (1) CY1112781T1 (es)
DK (1) DK2207786T3 (es)
EA (1) EA018757B1 (es)
EC (1) ECSP10010095A (es)
ES (2) ES2616566T3 (es)
FI (2) FIC20230039I1 (es)
FR (2) FR23C1051I1 (es)
GT (1) GT201000088A (es)
HK (1) HK1146410A1 (es)
HR (1) HRP20120419T1 (es)
HU (2) HUS2300044I1 (es)
IL (1) IL204732A (es)
JO (1) JO2778B1 (es)
ME (1) ME00997B (es)
MX (1) MX2010004109A (es)
MY (1) MY147970A (es)
NI (1) NI201000055A (es)
NL (1) NL301256I2 (es)
NO (2) NO2023048I1 (es)
NZ (1) NZ584229A (es)
PL (1) PL2207786T3 (es)
PT (1) PT2207786E (es)
RS (1) RS52323B (es)
SA (1) SA08290661B1 (es)
SI (1) SI2207786T1 (es)
TW (1) TWI445539B (es)
UA (1) UA99476C2 (es)
WO (1) WO2009052287A1 (es)
ZA (1) ZA201002178B (es)

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KR20100091978A (ko) 2010-08-19
NO2023048I1 (en) 2023-12-21
NZ584229A (en) 2012-06-29
GT201000088A (es) 2012-03-13
AU2008312435A8 (en) 2014-07-24
RS52323B (en) 2012-12-31
IL204732A0 (en) 2010-11-30
US20120289475A1 (en) 2012-11-15
ATE548374T1 (de) 2012-03-15
IL204732A (en) 2013-07-31
ES2616566T3 (es) 2017-06-13
BRPI0818672B8 (pt) 2021-05-25
PL2207786T3 (pl) 2012-09-28
SI2207786T1 (sl) 2012-10-30
JO2778B1 (en) 2014-03-15
EA201000642A1 (ru) 2010-10-29
CN101827856A (zh) 2010-09-08
JP2011500713A (ja) 2011-01-06
CA2702274C (en) 2015-12-29
EP2447272B1 (en) 2017-02-01
EP2207786A1 (en) 2010-07-21
EA018757B1 (ru) 2013-10-30
US20140186335A1 (en) 2014-07-03
AU2008312435A1 (en) 2009-04-23
ECSP10010095A (es) 2010-07-30
CR11427A (es) 2010-08-16
BRPI0818672B1 (pt) 2020-10-20
NL301256I2 (nl) 2024-01-11
PT2207786E (pt) 2012-05-28
NO2023047I1 (no) 2023-12-21
FR23C1051I1 (fr) 2024-01-26
SA08290661B1 (ar) 2012-06-10
NL301256I1 (es) 2024-01-03
JP5859588B2 (ja) 2016-02-10
CN101827856B (zh) 2013-02-06
DK2207786T3 (da) 2012-06-18
UA99476C2 (en) 2012-08-27
CA2702274A1 (en) 2009-04-23
US8951987B2 (en) 2015-02-10
KR101543049B1 (ko) 2015-08-07
HUS2300045I1 (hu) 2024-01-28
EP2447272A1 (en) 2012-05-02
FIC20230040I1 (fi) 2023-12-22
ZA201002178B (en) 2011-05-25
JP2014177455A (ja) 2014-09-25
FIC20230039I1 (fi) 2023-12-22
BRPI0818672A2 (pt) 2015-04-14
NI201000055A (es) 2010-08-13
US8268800B2 (en) 2012-09-18
FR23C1052I1 (fr) 2024-01-26
HRP20120419T1 (hr) 2012-07-31
EP2207786B1 (en) 2012-03-07
MY147970A (en) 2013-02-28
HK1146410A1 (en) 2011-06-03
WO2009052287A1 (en) 2009-04-23
US9567363B2 (en) 2017-02-14
CO6270330A2 (es) 2011-04-20
ME00997B (me) 2012-10-20
US8618075B2 (en) 2013-12-31
ES2384011T3 (es) 2012-06-28
HUS2300044I1 (hu) 2024-01-28
JP5496899B2 (ja) 2014-05-21
TW200924786A (en) 2009-06-16
US20150210730A1 (en) 2015-07-30
US20090137521A1 (en) 2009-05-28
CY1112781T1 (el) 2016-02-10
TWI445539B (zh) 2014-07-21
AU2008312435B2 (en) 2014-04-17

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