NO301233B1 - Fremgangsmåte for fremstilling av et sett av polymerer, apparat for fremstilling av en pluralitet av polymerer i henhold til fremgangsmåten og substrat for screening av forbindelser med hensyn på biologisk aktivitet - Google Patents

Fremgangsmåte for fremstilling av et sett av polymerer, apparat for fremstilling av en pluralitet av polymerer i henhold til fremgangsmåten og substrat for screening av forbindelser med hensyn på biologisk aktivitet Download PDF

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Publication number
NO301233B1
NO301233B1 NO914826A NO914826A NO301233B1 NO 301233 B1 NO301233 B1 NO 301233B1 NO 914826 A NO914826 A NO 914826A NO 914826 A NO914826 A NO 914826A NO 301233 B1 NO301233 B1 NO 301233B1
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Prior art keywords
substrate
light
monomer
sequences
receptor
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NO914826A
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English (en)
Norwegian (no)
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NO914826L (no
NO914826D0 (no
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Michael C Pirrung
Leighton J Read
Stephen P A Fodor
Lubert Stryer
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Affymax Tech Nv
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Application filed by Affymax Tech Nv filed Critical Affymax Tech Nv
Publication of NO914826L publication Critical patent/NO914826L/no
Publication of NO914826D0 publication Critical patent/NO914826D0/no
Publication of NO301233B1 publication Critical patent/NO301233B1/no

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    • C08G69/00Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809Multifield plates or multicontainer arrays
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31971Of carbohydrate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575Volumetric liquid transfer

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NO914826A 1989-06-07 1991-12-06 Fremgangsmåte for fremstilling av et sett av polymerer, apparat for fremstilling av en pluralitet av polymerer i henhold til fremgangsmåten og substrat for screening av forbindelser med hensyn på biologisk aktivitet NO301233B1 (no)

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US36290189A 1989-06-07 1989-06-07
US07/492,462 US5143854A (en) 1989-06-07 1990-03-07 Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
PCT/NL1990/000081 WO1990015070A1 (en) 1989-06-07 1990-06-07 Very large scale immobilized peptide synthesis

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Families Citing this family (3534)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866363A (en) * 1985-08-28 1999-02-02 Pieczenik; George Method and means for sorting and identifying biological information
US6270961B1 (en) * 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5242974A (en) * 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5871928A (en) * 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5527681A (en) * 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US6040423A (en) * 1990-08-31 2000-03-21 Gsellschaft Fur Biotechnologische Forschung Mbh (Gbf) Process for synthesis of peptides
EP1046421B8 (en) * 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Methods and reagents for very large scale immobilized polymer synthesis
DE69132843T2 (de) 1990-12-06 2002-09-12 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Identifizierung von Nukleinsäuren in Proben
US5658728A (en) * 1991-06-19 1997-08-19 Gosney, Jr.; William Milton Templates for nucleic acid molecules
GB2258236B (en) * 1991-07-30 1995-03-22 Hitachi Europ Ltd Molecular synthesis
US5449754A (en) * 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
AU2422492A (en) * 1991-08-07 1993-03-02 H & N Instruments, Inc. Synthesis of chain chemical compounds
JPH05206017A (ja) * 1991-08-09 1993-08-13 Internatl Business Mach Corp <Ibm> リソグラフイ露光システム及びその方法
US6589726B1 (en) 1991-09-04 2003-07-08 Metrigen, Inc. Method and apparatus for in situ synthesis on a solid support
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6921636B1 (en) * 1991-09-04 2005-07-26 Metrigen, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
CA2118806A1 (en) * 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733731A (en) * 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US6652808B1 (en) 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US6569382B1 (en) 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6017696A (en) * 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5556961A (en) * 1991-11-15 1996-09-17 Foote; Robert S. Nucleosides with 5'-O-photolabile protecting groups
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5550215A (en) * 1991-11-22 1996-08-27 Holmes; Christopher P. Polymer reversal on solid surfaces
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5324633A (en) * 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6943034B1 (en) * 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
DE69333650T2 (de) * 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5359115A (en) * 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5648458A (en) * 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5643873A (en) * 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5728802A (en) * 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5849545A (en) * 1992-05-11 1998-12-15 Evotec Biosystems Gmbh Substrate material for simultaneously binding genotypic and phenotypic substances
JPH0622798A (ja) * 1992-07-07 1994-02-01 Hitachi Ltd 塩基配列決定法
US5585275A (en) * 1992-09-02 1996-12-17 Arris Pharmaceutical Corporation Pilot apparatus for peptide synthesis and screening
US5591646A (en) * 1992-09-02 1997-01-07 Arris Pharmaceutical Method and apparatus for peptide synthesis and screening
US5420328A (en) * 1992-09-11 1995-05-30 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5714127A (en) * 1992-10-08 1998-02-03 Warner-Lambert Company System for multiple simultaneous synthesis
US5702672A (en) * 1992-10-08 1997-12-30 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5567391A (en) * 1992-10-08 1996-10-22 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5554501A (en) * 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
AU5449094A (en) * 1992-11-02 1994-05-24 Affymax Technologies N.V. Novel photoreactive protecting groups
AU680450B2 (en) * 1992-11-06 1997-07-31 Mimotopes Pty Ltd Support for the synthesis of modular polymers
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2156717C (en) * 1993-02-23 2001-05-29 Daniel E. Kahne Solution and solid-phase formation of glycosidic linkages
US6864048B2 (en) * 1993-04-28 2005-03-08 Affymetrix, Inc. Factorial chemical libraries
US6632613B1 (en) * 1993-06-02 2003-10-14 University Of Utah Research Foundation Compositions and kits for fluorescence polarization assay of large molecules
US6008058A (en) * 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US6153379A (en) * 1993-06-22 2000-11-28 Baylor College Of Medicine Parallel primer extension approach to nucleic acid sequence analysis
US7001722B1 (en) 1993-06-22 2006-02-21 Baylor College Of Medicine Parallel primer extension approach to nucleic acid sequence analysis
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US20030134291A1 (en) * 1993-06-25 2003-07-17 Affymetrix, Inc. Polymorphism detection
US5861242A (en) * 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
JP3954092B2 (ja) 1993-06-25 2007-08-08 アフィメトリックス インコーポレイテッド 核酸配列のハイブリダイゼーションと配列決定
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
WO1995003401A1 (en) * 1993-07-23 1995-02-02 Hyseq, Inc. Method for screening unknown organisms
US6401267B1 (en) * 1993-09-27 2002-06-11 Radoje Drmanac Methods and compositions for efficient nucleic acid sequencing
JPH0798276A (ja) * 1993-09-28 1995-04-11 Hitachi Electron Eng Co Ltd Dna塩基配列決定装置
US6180239B1 (en) 1993-10-04 2001-01-30 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
US6776094B1 (en) * 1993-10-04 2004-08-17 President & Fellows Of Harvard College Kit For Microcontact Printing
US5776748A (en) * 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5900160A (en) * 1993-10-04 1999-05-04 President And Fellows Of Harvard College Methods of etching articles via microcontact printing
JPH09504522A (ja) * 1993-10-12 1997-05-06 グリコメド・インコーポレイテッド 細胞接着インヒビターの同定に有用なグリコ−ペプチドのライブラリー
US20060229824A1 (en) * 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US20120329677A9 (en) * 1993-10-26 2012-12-27 Cronin Maureen T Arrays of nucleic acid probes for detecting cystic fibrosis
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US7375198B2 (en) * 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US20030232361A1 (en) * 1993-10-26 2003-12-18 Affymetrix, Inc. Nucleic acid array preparation using purified phosphoramidites
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
US6156501A (en) * 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US6893816B1 (en) 1993-10-28 2005-05-17 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
JP3488465B2 (ja) * 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5429807A (en) * 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5922545A (en) * 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US6315953B1 (en) 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6375899B1 (en) 1993-11-01 2002-04-23 Nanogen, Inc. Electrophoretic buss for transport of charged materials in a multi-chamber system
US7314708B1 (en) 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US6306348B1 (en) * 1993-11-01 2001-10-23 Nanogen, Inc. Inorganic permeation layer for micro-electric device
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US7172864B1 (en) * 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US6254827B1 (en) 1993-11-01 2001-07-03 Nanogen, Inc. Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US6726880B1 (en) 1993-11-01 2004-04-27 Nanogen, Inc. Electronic device for performing active biological operations and method of using same
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US7034110B2 (en) * 1994-01-05 2006-04-25 Arqule, Inc. Method of identifying chemical compounds having selected properties for a particular application
GB9401833D0 (en) * 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
US20030017081A1 (en) * 1994-02-10 2003-01-23 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US6741344B1 (en) * 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
GB9404709D0 (en) * 1994-03-11 1994-04-27 Multilyte Ltd Binding assay
US6015880A (en) * 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
US5502246A (en) * 1994-03-22 1996-03-26 Eli Lilly And Company Solid-phase synthesis utilizing photochemical carbon-sulfur bond cleavage of thioethers
EP0751950B1 (en) * 1994-03-23 2000-10-25 The Penn State Research Foundation Method for identifying members of combinatorial libraries
US5871918A (en) * 1996-06-20 1999-02-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US5571639A (en) * 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US7615368B1 (en) 1994-06-17 2009-11-10 The Board Of Trustees Of The Leland Stanford Junior University Microarrays of polypeptides
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5525735A (en) * 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5525734A (en) * 1994-06-22 1996-06-11 Affymax Technologies N.V. Methods for synthesizing diverse collections of pyrrolidine compounds
US5679773A (en) * 1995-01-17 1997-10-21 Affymax Technologies N.V Reagants and methods for immobilized polymer synthesis and display
JPH10507160A (ja) * 1994-06-23 1998-07-14 アフィマックス テクノロジーズ エヌ.ブイ. 光活性化合物およびその使用方法
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US7857957B2 (en) 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US5710000A (en) * 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
US6327031B1 (en) * 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US6558633B1 (en) 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US7767627B1 (en) 1994-10-18 2010-08-03 Symyx Solutions, Inc. Combinatorial synthesis of inorganic or composite materials
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6004617A (en) * 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US8236493B2 (en) 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
AU705351B2 (en) * 1994-11-10 1999-05-20 Orchid Biosciences, Inc. Liquid distribution system
US5486633A (en) * 1994-11-10 1996-01-23 Duke University Photochemically-removable silyl protecting groups
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
SE9404166D0 (sv) * 1994-11-30 1994-11-30 Pharmacia Biotech Ab Multifunctional surfaces
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5622826A (en) * 1994-12-22 1997-04-22 Houston Advanced Research Center Method for immobilization of molecules on platinum solid support surfaces
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
US6239273B1 (en) 1995-02-27 2001-05-29 Affymetrix, Inc. Printing molecular library arrays
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5599695A (en) * 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5908926A (en) * 1995-03-16 1999-06-01 Duke University 5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group
US6428955B1 (en) 1995-03-17 2002-08-06 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US6025129A (en) * 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6416714B1 (en) * 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5677280A (en) * 1995-06-07 1997-10-14 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5683983A (en) * 1995-06-07 1997-11-04 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5958792A (en) * 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
EP1961760A3 (en) 1995-06-07 2008-09-03 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US6132971A (en) * 1995-06-27 2000-10-17 The University Of North Carolina At Chapel Hill Microelectronic device
US5968745A (en) * 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6361951B1 (en) 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US6387625B1 (en) 1995-06-27 2002-05-14 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6180346B1 (en) 1995-06-27 2001-01-30 The Universtiy Of North Carolina At Chapel Hill Electropolymerizable film, and method of making and use thereof
US6346387B1 (en) 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20050100946A1 (en) * 1995-06-29 2005-05-12 Affymetrix, Inc. Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
US5968740A (en) * 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6326140B1 (en) 1995-08-09 2001-12-04 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5759779A (en) * 1995-08-29 1998-06-02 Dehlinger; Peter J. Polynucleotide-array assay and methods
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US7026114B1 (en) * 1995-09-13 2006-04-11 Affymetrix, Inc. Methods and compositions for monitoring polymer array synthesis
US5733729A (en) * 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6132580A (en) * 1995-09-28 2000-10-17 The Regents Of The University Of California Miniature reaction chamber and devices incorporating same
US20040175718A1 (en) * 1995-10-16 2004-09-09 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation
US5658734A (en) * 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
US7455964B1 (en) 1996-07-15 2008-11-25 The Hospital For Sick Children Genes from the 20q13 amplicon and their uses
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6300063B1 (en) 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
US6953663B1 (en) * 1995-11-29 2005-10-11 Affymetrix, Inc. Polymorphism detection
US6022963A (en) * 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6147205A (en) * 1995-12-15 2000-11-14 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
US20110028350A1 (en) * 1995-12-15 2011-02-03 Affymetrix, Inc. Photocleavable protecting groups
US6660233B1 (en) * 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
US7291463B2 (en) * 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
US6864059B2 (en) * 1996-01-23 2005-03-08 Affymetrix, Inc. Biotin containing C-glycoside nucleic acid labeling compounds
US20010018514A1 (en) * 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US20040210045A1 (en) * 1996-01-23 2004-10-21 Mcgall Glenn Nucleic acid labeling compounds
US7282327B2 (en) * 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
US7423143B2 (en) * 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7527928B2 (en) * 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
EP1728875A3 (en) 1996-02-08 2007-05-09 Affymetrix, Inc. Chip-based speciation and phenotypic characterization of microorganisms
US6924094B1 (en) * 1996-02-08 2005-08-02 Affymetrix, Inc. Chip-based species identification and phenotypic characterization of microorganisms
JP2000504575A (ja) 1996-02-08 2000-04-18 アフィメトリックス,インコーポレイテッド 微生物のチップベースの種分化および表現型特徴付け
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
EP2368897B1 (en) * 1996-02-09 2016-10-19 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6130322A (en) * 1996-02-12 2000-10-10 Gene Logic, Inc. Coding sequences of the human BRCA1 gene
US6838256B2 (en) 1996-02-12 2005-01-04 Gene Logic Inc. Coding sequences of the human BRCA1 gene
US20030022184A1 (en) * 1996-02-12 2003-01-30 Oncormed. Inc. Coding sequences of the human BRCA1 gene
DE19609272C2 (de) * 1996-02-27 2000-05-25 Schering Ag Verfahren zur Parallelsynthese großer Zahlen von 2,6-disubstituierten Chinolinderivaten
US6063633A (en) 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
EP0886681A1 (en) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
JP2000508624A (ja) * 1996-03-08 2000-07-11 スミスクライン・ビーチャム・コーポレイション コンビナトリアルライブラリーのスクリーニングの間にタンパク質の化学物質に対する親和性を測定する方法
FR2775984B1 (fr) 1998-03-11 2006-09-15 Bioscreen Therapeutics Sa Criblage differentiel qualitatif
US6881571B1 (en) 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
US20030165931A1 (en) * 1998-03-11 2003-09-04 Bruno Tocque Qualitative differential screening
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
WO1997035033A1 (en) 1996-03-19 1997-09-25 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
US6361937B1 (en) 1996-03-19 2002-03-26 Affymetrix, Incorporated Computer-aided nucleic acid sequencing
US6528324B1 (en) * 1996-03-22 2003-03-04 Ontogen Corporation Apparatus for pre-determined mass sorting of positional-encoded solid phase synthesis supports
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
DE19612356B4 (de) * 1996-03-28 2007-04-26 Clondiag Chip Technologies Gmbh Optischer Nachweis von Hybridisierungs-Signalen
US6458530B1 (en) 1996-04-04 2002-10-01 Affymetrix Inc. Selecting tag nucleic acids
US6706875B1 (en) * 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
WO1997041139A2 (en) 1996-04-17 1997-11-06 Koester Hubert A combinatorial protecting group strategy for multifunctional molecules
US5733509A (en) * 1996-04-17 1998-03-31 Motorola, Inc. Method and system for synthesizing oligonucleotides using nucleotide-specific dispensing bars
CA2255599C (en) * 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
WO1997043611A1 (en) 1996-05-16 1997-11-20 Affymetrix, Inc. Systems and methods for detection of labeled materials
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
EP1736554B1 (en) * 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US20060141539A1 (en) * 1996-05-30 2006-06-29 Taylor D L Miniaturized cell array methods and apparatus for cell-based screening
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6057100A (en) * 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US5914229A (en) * 1996-06-14 1999-06-22 Sarnoff Corporation Method for amplifying a polynucleotide
CA2258511A1 (en) * 1996-06-14 1997-12-18 Sarnoff Corporation Method for polynucleotide sequencing
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US5912124A (en) * 1996-06-14 1999-06-15 Sarnoff Corporation Padlock probe detection
SE9602545L (sv) * 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
US20050069923A1 (en) * 1996-07-08 2005-03-31 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US6331275B1 (en) 1996-07-08 2001-12-18 Burstein Technologies, Inc. Spatially addressable, cleavable reflective signal elements, assay device and method
US20050214827A1 (en) * 1996-07-08 2005-09-29 Burstein Technologies, Inc. Assay device and method
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
AU725065B2 (en) 1996-07-08 2000-10-05 Burstein Technologies, Inc. Cleavable signal element device and method
DE19629141A1 (de) * 1996-07-19 1998-04-16 Bayer Ag Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand
US5922872A (en) * 1996-08-01 1999-07-13 Isis Pharmaceuticals, Inc. Meta-benzylic and alpha-amido compositions and methods for preparing same
US5817489A (en) 1996-08-01 1998-10-06 Isis Pharmaceuticals, Inc. Di-nitrogen heterocycle compositions
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
US5798360A (en) * 1996-08-01 1998-08-25 Isis Pharmaceuticals, Inc. N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
US5858666A (en) * 1996-08-29 1999-01-12 Biotechnology Research And Development Corporation Apparatus and method of detection employing an AC frequency sensor array
US6020047A (en) * 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
WO1998012559A1 (en) * 1996-09-20 1998-03-26 Demers James P Spatially addressable combinatorial chemical arrays in cd-rom format
SG94355A1 (en) 1996-10-01 2003-02-18 Geron Corp Human telomerase catalytic subunit
WO1998014641A1 (en) 1996-10-02 1998-04-09 Symyx Technologies Potential masking systems and methods for combinatorial library synthesis
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
US6738529B1 (en) 1996-10-09 2004-05-18 Symyx Technologies, Inc. Analysis of chemical data from images
US5762881A (en) * 1996-10-29 1998-06-09 Bohdan Automation, Inc. Apparatus for multiple, simultaneous synthesis of organic compounds
US6875620B1 (en) 1996-10-31 2005-04-05 Agilent Technologies, Inc. Tiling process for constructing a chemical array
US5780241A (en) 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
EP1457496B1 (en) 1996-11-06 2014-01-15 Sequenom, Inc. High density immobilization of nucleic acids
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US20030129589A1 (en) 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
US7285422B1 (en) * 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US6441172B1 (en) * 1996-11-07 2002-08-27 Torrey Pines Institute For Molecular Studies Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
DE69720041T2 (de) * 1996-11-14 2004-01-08 Affymetrix, Inc., Santa Clara Chemische amplifizierung zur synthese von musterordnungen
US6887665B2 (en) * 1996-11-14 2005-05-03 Affymetrix, Inc. Methods of array synthesis
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5780603A (en) * 1996-11-15 1998-07-14 Synsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
AU5794498A (en) 1996-12-10 1998-07-03 Genetrace Systems, Inc. Releasable nonvolatile mass-label molecules
US5942397A (en) * 1996-12-11 1999-08-24 Tarlov; Michael J. Surface immobilization of biopolymers
US6458547B1 (en) 1996-12-12 2002-10-01 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
WO1998027430A1 (en) * 1996-12-17 1998-06-25 Affymetrix Inc. Lithographic mask design and synthesis of diverse probes on a substrate
US5922550A (en) * 1996-12-18 1999-07-13 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images
US6048623A (en) * 1996-12-18 2000-04-11 Kimberly-Clark Worldwide, Inc. Method of contact printing on gold coated films
JP2002514913A (ja) * 1996-12-19 2002-05-21 エール ユニバーシティ 生反応性アロステリックポリヌクレオチド
EP0990142A4 (en) * 1996-12-31 2000-09-27 Genometrix Genomics Inc MULTIPLEXED MOLECULAR ANALYSIS METHOD AND DEVICE
US7670767B1 (en) 1997-01-16 2010-03-02 The Regents Of The University Of California Genetic alterations associated with cancer
US6277563B1 (en) 1997-01-16 2001-08-21 The Regents Of The University Of California Genetic alterations associated with cancer
CN1238366C (zh) 1997-01-21 2006-01-25 综合医院公司 利用rna-蛋白融合体筛选蛋白
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US5837475A (en) * 1997-01-30 1998-11-17 Hewlett-Packard Co. Apparatus and method for scanning a chemical array
US6262269B1 (en) 1997-02-04 2001-07-17 Trega Biosciences, Inc. 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries
US5773308A (en) * 1997-02-10 1998-06-30 The United States Of America As Represented By The Secretary Of The Navy Photoactivatable o-nitrobenzyl polyethylene glycol-silane for the production of patterned biomolecular arrays
WO1998035012A2 (en) 1997-02-12 1998-08-13 Chan Eugene Y Methods and products for analyzing polymers
US6187536B1 (en) 1997-02-18 2001-02-13 Thomas Jefferson University Methods of identifying and detecting pancreatic cancer
US6727071B1 (en) 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
JP3683591B2 (ja) 1997-02-27 2005-08-17 セロミックス インコーポレイテッド 細胞に基づくスクリーニングシステム
US7117098B1 (en) 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
US6165709A (en) 1997-02-28 2000-12-26 Fred Hutchinson Cancer Research Center Methods for drug target screening
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6419883B1 (en) 1998-01-16 2002-07-16 University Of Washington Chemical synthesis using solvent microdroplets
US6028189A (en) * 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
AU751956B2 (en) 1997-03-20 2002-09-05 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US6180288B1 (en) 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
CA2284612A1 (en) 1997-04-04 1998-10-15 Michael Knapp Closed-loop biochemical analyzers
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US5772855A (en) * 1997-04-17 1998-06-30 Bend Research, Inc. Preparation of bioactive compounds by plasma synthesis
US6558901B1 (en) * 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US7101672B2 (en) * 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6214545B1 (en) 1997-05-05 2001-04-10 Third Wave Technologies, Inc Polymorphism analysis by nucleic acid structure probing
US6194149B1 (en) 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6210880B1 (en) 1997-09-19 2001-04-03 Third Wave Technologies, Inc. Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides
CA2289872C (en) 1997-05-05 2007-07-31 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6159681A (en) * 1997-05-28 2000-12-12 Syntrix Biochip, Inc. Light-mediated method and apparatus for the regional analysis of biologic material
US6350609B1 (en) * 1997-06-20 2002-02-26 New York University Electrospraying for mass fabrication of chips and libraries
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6368877B1 (en) * 1997-06-25 2002-04-09 Massachusetts Institute Of Technology Self-assembling peptide surfaces for cell patterning and interactions
EP0991930B1 (en) * 1997-06-26 2004-06-16 Perseptive Biosystems, Inc. High density sample holder for analysis of biological samples
US6151123A (en) * 1997-07-14 2000-11-21 Symyx Technologies, Inc. Systems and methods for employing optical probes to characterize material properties
IL121312A (en) * 1997-07-14 2001-09-13 Technion Res & Dev Foundation Microelectronic components, their manufacture and electronic networks containing them
HUP0002518A3 (en) 1997-07-22 2003-01-28 Qiagen Genomics Inc Computer method and system for correlating sequencing data by ms
HUP0003296A3 (en) 1997-07-22 2001-09-28 Qiagen Genomics Inc Bothell Apparatus and methods for arraying solution onto a solid support
NZ501917A (en) 1997-07-22 2001-10-26 Qiagen Genomics Inc Method and apparatus for enzymatic reactions performed on nucleic acid arrays conducted at dew point
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
US7068830B2 (en) * 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6420108B2 (en) * 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
ATE264523T1 (de) * 1997-07-25 2004-04-15 Affymetrix Inc A Delaware Corp Verfahren zur herstellung einer bio-informatik- datenbank
WO1999006833A1 (en) * 1997-07-29 1999-02-11 Huston James S Methods for obtaining probes of peptide function
US6391655B1 (en) 1997-07-30 2002-05-21 Corning Incorporated Oxidized styrenic polymers for DNA binding
JP4313861B2 (ja) * 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US6290685B1 (en) 1998-06-18 2001-09-18 3M Innovative Properties Company Microchanneled active fluid transport devices
DE69841171D1 (de) 1997-08-01 2009-11-05 Canon Kk Reaktionsstellenarray, Verfahren zu seiner Herstellung, Reaktionsverfahren unter seiner Verwendung und quantitatives Bestimmungsverfahren für eine Substanz in einer Probelösung unter seiner Verwendung
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
US7135333B1 (en) 1997-08-07 2006-11-14 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
US6120995A (en) * 1997-08-07 2000-09-19 Thomas Jefferson University Compositions that specifically bind to colorectal cancer cells and methods of using the same
JP2001514887A (ja) 1997-08-15 2001-09-18 オンコーメッド・インコーポレイテッド ヒトbrca2遺伝子のコード配列半数型
US20090269814A1 (en) * 1998-05-22 2009-10-29 Murphy Patricia D Method of Analyzing a BRCA2 Gene in a Human Subject
US6410342B1 (en) * 1997-08-19 2002-06-25 Pharmacopeia, Inc. Method and apparatus for controlled photoelution
US7252950B1 (en) 1997-09-04 2007-08-07 The Regents Of The University Of California Assays for detecting modulators of cytoskeletal function
US6432639B1 (en) 1997-09-10 2002-08-13 Dna Sciences Laboratories, Inc. Isolated CYP3A4 nucleic acid molecules and detection methods
PT1012564E (pt) * 1997-09-11 2003-08-29 Bioventures Inc Metodo de producao de arranjos de alta densidade
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6492109B1 (en) 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
US20030104481A1 (en) * 1997-09-30 2003-06-05 Symyx Technologies Potential masking systems and methods for combinatorial library synthesis
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
EP1021558A1 (en) 1997-10-10 2000-07-26 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
WO1999019341A1 (en) 1997-10-10 1999-04-22 President & Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US20020155495A1 (en) * 2000-04-17 2002-10-24 Millstein Larry S. Method for producing arrays and devices relating thereto
US6348322B1 (en) 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US7351578B2 (en) 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
US6156494A (en) * 1997-10-28 2000-12-05 Mosaic Technologies Serially directed combinatorial synthesis on fiber optic arrays
WO1999023256A1 (en) * 1997-10-30 1999-05-14 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
US6322968B1 (en) 1997-11-21 2001-11-27 Orchid Biosciences, Inc. De novo or “universal” sequencing array
US6101946A (en) * 1997-11-21 2000-08-15 Telechem International Inc. Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
US6794133B1 (en) 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
US6274383B1 (en) 1997-12-15 2001-08-14 Sepracor Inc. Methods for synthesizing libraries of dihydro-quinazolinones
US6184377B1 (en) 1997-12-15 2001-02-06 Sepracor Inc. Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
US20070166741A1 (en) * 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6060256A (en) 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6093302A (en) 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6265163B1 (en) 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes
ATE477850T1 (de) * 1998-01-12 2010-09-15 Massachusetts Inst Technology Vorrichtung zur mikrotestdurchführung
US6893877B2 (en) * 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
US6201639B1 (en) 1998-03-20 2001-03-13 James W. Overbeck Wide field of view and high speed scanning microscopy
US20020164585A1 (en) * 1998-01-16 2002-11-07 Sean Chapman Method for enhancing RNA or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids
US6303848B1 (en) 1998-01-16 2001-10-16 Large Scale Biology Corporation Method for conferring herbicide, pest, or disease resistance in plant hosts
US6426185B1 (en) 1998-01-16 2002-07-30 Large Scale Biology Corporation Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation
US20030166169A1 (en) * 1998-01-16 2003-09-04 Padgett Hal S. Method for constructing viral nucleic acids in a cell-free manner
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
WO1999036576A1 (en) * 1998-01-20 1999-07-22 Packard Bioscience Company Gel pad arrays and methods and systems for making them
DE19802576B4 (de) * 1998-01-23 2004-10-28 Xerion Pharmaceuticals Ag Verfahren zur gleichzeitigen Identifizierung von Proteinen und ihren Bindungspartnern
US6043294A (en) * 1998-01-29 2000-03-28 Gate Technologies International, Inc. Method of and apparatus for optically enhancing chemical reactions
US6741956B1 (en) 1998-02-03 2004-05-25 Lucent Technologies Inc. Analog computation using hybridization-capable oligomers
US6537747B1 (en) 1998-02-03 2003-03-25 Lucent Technologies Inc. Data transmission using DNA oligomers
US6150102A (en) * 1998-02-03 2000-11-21 Lucent Technologies Inc. Method of generating nucleic acid oligomers of known composition
EP2189791A3 (en) 1998-02-04 2011-03-09 Life Technologies Corporation Microarrays and uses therefor
EP0947246B1 (en) * 1998-02-04 2004-08-18 Corning Incorporated Substrate for array printing
US20040265838A1 (en) * 1998-02-06 2004-12-30 Affymetrix, Inc. Method of manufacturing
US7399589B2 (en) * 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US20040035690A1 (en) * 1998-02-11 2004-02-26 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
AU772531B2 (en) * 1998-02-11 2004-04-29 University Of Houston, The Method and apparatus for chemical and biochemical reactions using photo-generated reagents
DE69909972T2 (de) * 1998-02-11 2004-05-13 University Of Houston, Houston Vorrichtung zur durchführung chemischer und biochemischer reaktionen unter anwendung von photoerzeugten reagenzien
US6537505B1 (en) 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
JP2002540380A (ja) * 1998-02-21 2002-11-26 ウィッシス・テクノロジー・ファウンデーション・インコーポレイテッド 一次元の化学化合物アレイ及びそれらのアセイ方法
WO1999042813A1 (en) 1998-02-23 1999-08-26 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
US20020090639A1 (en) * 1998-02-26 2002-07-11 Mcginnis Ralph Evan Two dimensional linkage study methods and related inventions
US6087103A (en) * 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
EP1717249A1 (en) 1998-03-12 2006-11-02 Georgetown University Peptides containing a cholesterol recognition sequence and their uses
US6185030B1 (en) 1998-03-20 2001-02-06 James W. Overbeck Wide field of view and high speed scanning microscopy
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
EP1064378A2 (en) * 1998-03-27 2001-01-03 The Board Of Trustees Of The Leland Stanford Junior University Hypoxia-inducible human genes, proteins, and uses thereof
US6218114B1 (en) 1998-03-27 2001-04-17 Academia Sinica Methods for detecting differentially expressed genes
US6077673A (en) * 1998-03-31 2000-06-20 Clontech Laboratories, Inc. Mouse arrays and kits comprising the same
ATE546544T1 (de) * 1998-03-31 2012-03-15 Esoterix Genetic Lab Llc Verfahren zur diagnose und behandlung von lungenkrebs
JP2002510505A (ja) * 1998-04-03 2002-04-09 フィロス インク. 位置特定可能な蛋白質アレイ
US7108968B2 (en) * 1998-04-03 2006-09-19 Affymetrix, Inc. Mycobacterial rpoB sequences
US6284497B1 (en) * 1998-04-09 2001-09-04 Trustees Of Boston University Nucleic acid arrays and methods of synthesis
US6376619B1 (en) * 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
JP2002512045A (ja) * 1998-04-20 2002-04-23 アフィメトリックス インコーポレイテッド 核酸プローブアレイに対する非特異的な結合を減少させるための方法
WO1999055886A1 (en) * 1998-04-24 1999-11-04 Genova Pharmaceuticals Corporation Function-based gene discovery
EP0955084B1 (en) 1998-04-27 2006-07-26 Corning Incorporated Method of depositing an array of biological samples using a redrawn capillary reservoir
US6355419B1 (en) 1998-04-27 2002-03-12 Hyseq, Inc. Preparation of pools of nucleic acids based on representation in a sample
US6884626B1 (en) 1998-04-27 2005-04-26 Corning Incorporated Redrawn capillary imaging reservoir
US6350618B1 (en) 1998-04-27 2002-02-26 Corning Incorporated Redrawn capillary imaging reservoir
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US20080050836A1 (en) * 1998-05-01 2008-02-28 Isabelle Guyon Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia
US7617163B2 (en) * 1998-05-01 2009-11-10 Health Discovery Corporation Kernels and kernel methods for spectral data
US6130046A (en) * 1998-05-04 2000-10-10 Affymetrix, Inc. Techniques for synthesis integrity evaluation utilizing cycle fidelity probes
US6979728B2 (en) * 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
US20030203394A1 (en) * 1998-05-04 2003-10-30 Yoav Eichen Detection of a target in a sample
US6686163B2 (en) 1998-05-06 2004-02-03 Gene Logic Inc. Coding sequence haplotype of the human BRCA1 gene
US6324479B1 (en) 1998-05-08 2001-11-27 Rosetta Impharmatics, Inc. Methods of determining protein activity levels using gene expression profiles
US5992226A (en) * 1998-05-08 1999-11-30 The United States Of America As Represented By The Secretary Of The Navy Apparatus and method for measuring intermolecular interactions by atomic force microscopy
US5965352A (en) 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
DE19823454A1 (de) * 1998-05-18 1999-11-25 Epigenomics Gmbh Verfahren zur photolithographischen Herstellung von DNA, PNA und Protein Chips
DE19823660C1 (de) * 1998-05-20 1999-10-07 Nanomont Ges Fuer Nanotechnolo Verfahren und Vorrichtung zur Fixierung fester Mikro- und/oder Nanoobjekte
US6268210B1 (en) * 1998-05-27 2001-07-31 Hyseq, Inc. Sandwich arrays of biological compounds
AU4218499A (en) * 1998-05-27 1999-12-13 Syntrix Biochip Light-mediated method and apparatus for the regional analysis of biologic material
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US6086831A (en) * 1998-06-10 2000-07-11 Mettler-Toledo Bohdan, Inc. Modular reaction block assembly with thermoelectric cooling and heating
DE19826458A1 (de) * 1998-06-13 1999-12-16 Papst Motoren Gmbh & Co Kg Anordnung mit einem Elektromotor
US6872521B1 (en) 1998-06-16 2005-03-29 Beckman Coulter, Inc. Polymerase signaling assay
US6270730B1 (en) 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
US6251595B1 (en) 1998-06-18 2001-06-26 Agilent Technologies, Inc. Methods and devices for carrying out chemical reactions
US6132969A (en) * 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
ATE313548T1 (de) * 1998-06-22 2006-01-15 Affymetrix Inc Reagenz und verfahren zu fester phase synthese
US6235473B1 (en) 1998-07-02 2001-05-22 Orchid Biosciences, Inc. Gene pen devices for array printing
US6762061B1 (en) 1998-07-03 2004-07-13 Corning Incorporated Redrawn capillary imaging reservoir
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
WO2000003037A1 (en) * 1998-07-10 2000-01-20 The Board Of Trustees Of The Leland Stanford Junior University Screening arrays of nucleotides to determine correspondence with both sequence and physical properties of a probe
US6171794B1 (en) 1998-07-13 2001-01-09 Rosetta Inpharmatics, Inc. Methods for determining cross-hybridization
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6897073B2 (en) * 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6316229B1 (en) 1998-07-20 2001-11-13 Yale University Single molecule analysis target-mediated ligation of bipartite primers
EP1097378A2 (en) * 1998-07-21 2001-05-09 Burstein Laboratories Inc. Optical disc-based assay devices and methods
AU5255199A (en) * 1998-08-03 2000-02-28 California Institute Of Technology Method of determining cell or tissue type by transmembrane receptor identifiers
US20040029159A1 (en) * 1998-08-03 2004-02-12 Dreyer William J. Nucleic acid switch patterns as cell or tissue type identifiers
US6528026B2 (en) 1998-08-13 2003-03-04 Symyx Technologies, Inc. Multi-temperature modular reactor and method of using same
US6548026B1 (en) 1998-08-13 2003-04-15 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
US6864092B1 (en) 1998-08-13 2005-03-08 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6455316B1 (en) 1998-08-13 2002-09-24 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
DE19836882A1 (de) * 1998-08-14 2000-02-17 Papst Motoren Gmbh & Co Kg Anordnung mit einem Elektromotor
US6291190B1 (en) 1998-08-25 2001-09-18 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the M. tuberculosis complex
US6271042B1 (en) * 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
DE69925133T2 (de) * 1998-08-27 2006-01-19 Spirogen Ltd., Ryde Pyrrolobenzodiazepine
GB9818732D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB9818731D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818730D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
EP1117478B1 (de) 1998-08-28 2005-06-01 Febit AG Träger für analytbestimmungsverfahren und verfahren zur herstellung des trägers
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
US6929912B2 (en) * 1998-08-31 2005-08-16 Genaissance Pharmaceuticals, Inc. Methods for evaluating the ability to metabolize pharmaceuticals
US6461812B2 (en) * 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
JP4028964B2 (ja) * 1998-09-09 2008-01-09 日立ソフトウエアエンジニアリング株式会社 バイオチップ及びバイオチップの使用方法
AU770993B2 (en) 1998-09-15 2004-03-11 Yale University Molecular cloning using rolling circle amplification
JP2002525078A (ja) 1998-09-15 2002-08-13 イェール ユニバーシティ 人工的長末端反復配列
US6475440B1 (en) 1998-09-16 2002-11-05 Clontech Laboratories, Inc. Applicator for use in deposition of fluid samples onto a substrate surface
US20040199544A1 (en) * 2000-11-02 2004-10-07 Affymetrix, Inc. Method and apparatus for providing an expression data mining database
US20070178475A1 (en) * 1998-09-17 2007-08-02 Nehls Michael C Novel human polynucleotides and polypeptides encoded thereby
US6821724B1 (en) 1998-09-17 2004-11-23 Affymetrix, Inc. Methods of genetic analysis using nucleic acid arrays
KR100369694B1 (ko) * 1998-09-17 2003-01-29 인터내셔널 비지네스 머신즈 코포레이션 화학적 태그의 합성 방법
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US6146830A (en) 1998-09-23 2000-11-14 Rosetta Inpharmatics, Inc. Method for determining the presence of a number of primary targets of a drug
US20090119022A1 (en) * 1998-09-25 2009-05-07 Timberlake William E Emericella Nidulans Genome Sequence On Computer Readable Medium and Uses Thereof
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (en) * 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
AU5790199A (en) * 1998-10-05 2000-04-26 Duke University Method and apparatus for detecting binding interactions (in vivo)
US6682927B2 (en) * 1998-10-05 2004-01-27 Duke University Methods and apparatus for the high through-put detection of binding interactions in vivo
US7071324B2 (en) * 1998-10-13 2006-07-04 Brown University Research Foundation Systems and methods for sequencing by hybridization
US6593084B2 (en) 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
US6262216B1 (en) * 1998-10-13 2001-07-17 Affymetrix, Inc. Functionalized silicon compounds and methods for their synthesis and use
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
AU6515899A (en) * 1998-10-16 2000-05-08 Larry S. Millstein Methods of making patterned arrays of analyte-binding molecules
US7199809B1 (en) 1998-10-19 2007-04-03 Symyx Technologies, Inc. Graphic design of combinatorial material libraries
FR2784751B1 (fr) 1998-10-20 2001-02-02 Mesatronic Boitier de logement d'une puce electronique a sondes biologiques
WO2000023933A1 (en) * 1998-10-21 2000-04-27 Bios Group Lp Systems and methods for analysis of genetic networks
US7129043B1 (en) 1998-10-22 2006-10-31 Duke University Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6867289B1 (en) * 1998-10-26 2005-03-15 Board Of Regents, The University Of Texas Systems Thio-modified aptamer synthetic methods and compositions
US6468476B1 (en) * 1998-10-27 2002-10-22 Rosetta Inpharmatics, Inc. Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns
US6203987B1 (en) 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
IL126776A (en) 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
FR2785052B1 (fr) * 1998-10-27 2000-12-01 Commissariat Energie Atomique Dispositif de determination de la concentration d'une substance melangee a un fluorophore et procede de mise en oeuvre de ce dispositif
US6950752B1 (en) 1998-10-27 2005-09-27 Rosetta Inpharmatics Llc Methods for removing artifact from biological profiles
EP1126035A4 (en) * 1998-10-30 2002-09-11 Takara Shuzo Co METHOD FOR DETECTING GENES THAT ARE INTERRUPTED BY AN ENDOCRINE INTERRUPTER
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6399299B1 (en) 1998-11-02 2002-06-04 Perkinelmer Life Sciences, Inc. Amplified array analysis system
CA2348828C (en) * 1998-11-04 2009-09-15 Genset S.A. Genomic and complete cdna sequences of apm1 and biallelic markers thereof
US6187540B1 (en) 1998-11-09 2001-02-13 Identigene, Inc. Method of newborn identification and tracking
US20110014706A2 (en) * 1998-12-14 2011-01-20 Monsanto Technology Llc Arabidopsis thaliana Genome Sequence and Uses Thereof
US7135283B1 (en) 1998-11-17 2006-11-14 Nanogen, Inc. Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
DE19853640C2 (de) * 1998-11-20 2002-01-31 Molecular Machines & Ind Gmbh Mehrgefäßanordnung mit verbesserter Empfindlichkeit für die optische Analytik, Verfahren zu ihrer Herstellung sowie ihre Verwendung in optischen Analyseverfahren
DE19854946C2 (de) 1998-11-27 2002-01-03 Guenter Von Kiedrowski Klonieren und Kopieren an Oberflächen
US6951682B1 (en) * 1998-12-01 2005-10-04 Syntrix Biochip, Inc. Porous coatings bearing ligand arrays and use thereof
WO2000033084A2 (en) * 1998-12-01 2000-06-08 Syntrix Biochip, Inc. Arrays of organic compounds attached to surfaces
JP2002531615A (ja) 1998-12-01 2002-09-24 シントリックス バイオチップ, インコーポレイテッド 耐溶媒感光性組成物
WO2000032744A1 (en) * 1998-12-02 2000-06-08 Nanogen, Inc. Apparatus and methods for transport of charged biological materials
US6245518B1 (en) 1998-12-11 2001-06-12 Hyseq, Inc. Polynucleotide arrays and methods of making and using the same
US6221579B1 (en) 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
WO2000035940A2 (de) * 1998-12-14 2000-06-22 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren und vorrichtungen zum aufbringen von substanzen auf einen träger, insbesondere von monomeren für die kombinatorische synthese von molekülbibliotheken
US6579673B2 (en) 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US20030032029A1 (en) * 1998-12-21 2003-02-13 Nanogen, Inc. Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US6264891B1 (en) 1998-12-22 2001-07-24 Eos Biotechnology, Inc. Apparatus and method for concurrent chemical synthesis
DE19860547C1 (de) * 1998-12-23 2000-10-12 Genetrix B V I O Affinitätssensor für den Nachweis spezifischer molekularer Bindungsereignisse und dessen Verwendung
US6453241B1 (en) 1998-12-23 2002-09-17 Rosetta Inpharmatics, Inc. Method and system for analyzing biological response signal data
US6801859B1 (en) 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6370478B1 (en) 1998-12-28 2002-04-09 Rosetta Inpharmatics, Inc. Methods for drug interaction prediction using biological response profiles
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6570003B1 (en) * 2001-01-09 2003-05-27 Lexion Genetics Incorporated Human 7TM proteins and polynucleotides encoding the same
AU3050800A (en) 1999-01-05 2000-07-24 Bio Merieux Functionalised polynucleotide compound, optionally marked and method for detecting a target nucleic acid
JP4355384B2 (ja) 1999-01-14 2009-10-28 キヤノン株式会社 パターン露光方法、露光装置、核酸アレイの形成方法及びペプチドアレイの形成方法
AU2965500A (en) 1999-01-15 2000-08-01 Gene Logic, Inc. Immobilized nucleic acid hybridization reagent and method
US6232068B1 (en) 1999-01-22 2001-05-15 Rosetta Inpharmatics, Inc. Monitoring of gene expression by detecting hybridization to nucleic acid arrays using anti-heteronucleic acid antibodies
AU3150400A (en) * 1999-01-25 2000-08-07 Biochip Technologies Gmbh Immobilization of molecules on surfaces via polymer brushes
US6320196B1 (en) 1999-01-28 2001-11-20 Agilent Technologies, Inc. Multichannel high dynamic range scanner
US6514768B1 (en) * 1999-01-29 2003-02-04 Surmodics, Inc. Replicable probe array
US20030148360A1 (en) * 1999-01-29 2003-08-07 Surmodics, Inc. Replicable probe array
US6429302B1 (en) 1999-02-02 2002-08-06 Chiron Corporation Polynucleotides related to pancreatic disease
US20060234246A1 (en) * 1999-02-02 2006-10-19 Chiron Corporation Gene products differentially expressed in cancerous cells
US6605432B1 (en) * 1999-02-05 2003-08-12 Curators Of The University Of Missouri High-throughput methods for detecting DNA methylation
KR100497673B1 (ko) * 1999-02-10 2005-07-01 주식회사 마크로젠 광 변조기를 이용한 화학물질 라이브러리 제조 방법 및제조 장치
WO2000047598A1 (en) * 1999-02-10 2000-08-17 Macrogen Inc. Method and apparatus for compound library preparation using optical modulator
US6740875B1 (en) * 1999-02-11 2004-05-25 The Regents Of The University Of California Gamma watermarking
US6432719B1 (en) 1999-02-16 2002-08-13 Pe Corporation (Ny) Matrix storage and dispensing system
US7101510B2 (en) 1999-02-16 2006-09-05 Applera Corporation Matrix storage and dispensing system
DE60031015T2 (de) 1999-02-16 2007-05-10 Applera Corp., Foster City Vorrichtung zur Handhabung von Kügelchen
US20030027214A1 (en) * 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
DE50015858D1 (de) * 1999-02-19 2010-03-18 Febit Holding Gmbh Verfahren zur Herstellung von Polymeren
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US20040111219A1 (en) * 1999-02-22 2004-06-10 Sandeep Gulati Active interferometric signal analysis in software
US6245511B1 (en) * 1999-02-22 2001-06-12 Vialogy Corp Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
EP1586645A3 (en) * 1999-02-25 2006-02-22 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US6362907B1 (en) 1999-02-26 2002-03-26 Nec Research Institute, Inc. Apparatus and method for transmitting data between VLSI chips
WO2000052457A1 (en) * 1999-03-02 2000-09-08 Helix Biopharma Corporation Card-based biosensor device
WO2000052456A1 (en) 1999-03-02 2000-09-08 Helix Biopharma Corporation Biosensor device and method
AU2830400A (en) 1999-03-05 2000-09-28 Mitsubishi Rayon Company Limited Carriers having biological substance
US6716578B1 (en) 1999-03-08 2004-04-06 Bioforce Nanosciences, Inc. Method for solid state genome analysis
US7005256B1 (en) 1999-03-10 2006-02-28 Cold Spring Harbor Laboratory Gene chip technology for determining memory genes
CA2367925C (en) * 1999-03-11 2009-10-13 Combimatrix Corporation Self assembling arrays
CN1185492C (zh) 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
TW496775B (en) 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US6296702B1 (en) 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
US6403309B1 (en) 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
BR0009164A (pt) * 1999-03-19 2001-12-26 Genencor Int Placa de teste de múltiplos furos vazados paraseparação de alto desempenho
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
AU3867400A (en) * 1999-03-19 2000-10-09 Duke University Methods of using bioelastomers
WO2000058511A1 (en) * 1999-03-26 2000-10-05 Ludwig Institute For Cancer Research Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3)
US6764820B2 (en) * 1999-03-26 2004-07-20 Ludwig Institute For Cancer Research Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3)
WO2000058522A1 (en) * 1999-03-30 2000-10-05 Nanogen, Inc. Single nucleotide polymorphic discrimination by electronic dot blot assay on semiconductor microchips
EP1041385A3 (en) * 1999-03-30 2004-01-02 Fuji Photo Film Co., Ltd. Method and apparatus for detecting an organism-originated substance
WO2000058521A2 (en) * 1999-03-31 2000-10-05 Rosetta Inpharmatics, Inc. Methods for the identification of reporter and target molecules using comprehensive gene expression profiles
US6582906B1 (en) 1999-04-05 2003-06-24 Affymetrix, Inc. Proportional amplification of nucleic acids
JP4555484B2 (ja) 1999-04-07 2010-09-29 デニス マイケル コノリー 高解像度のdna検出の方法および装置
US6824866B1 (en) * 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
AU777774B2 (en) * 1999-04-09 2004-10-28 Gpc Biotech Ag Novel method for identifying antibacterial compounds
US20030133009A1 (en) * 1999-04-09 2003-07-17 Carl S Brown System and method for detecting with high resolution a large, high content field
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
CA2369016A1 (en) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
DE19916867A1 (de) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Anordnung und Verfahren zur Herstellung planarer Arrays mit immobilisierten Molekülen
EP1175505A4 (en) * 1999-04-15 2005-04-20 Vitra Bioscience Inc COMBINATORY CHEMICAL BANK HOLDERS HAVING BRANDS AT CODING POSITIONS, AND METHODS OF USE
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US6171793B1 (en) 1999-04-19 2001-01-09 Affymetrix, Inc. Method for scanning gene probe array to produce data having dynamic range that exceeds that of scanner
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6174683B1 (en) 1999-04-26 2001-01-16 Biocept, Inc. Method of making biochips and the biochips resulting therefrom
US6518056B2 (en) * 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
DE19918956A1 (de) * 1999-04-27 2000-11-02 Studiengesellschaft Kohle Mbh Verfahren zur automatisierten Untersuchung katalytischer und spektroskopischer Eigenschaften der Komponenten kombinatorischer Bibliotheken
US6300137B1 (en) * 1999-04-28 2001-10-09 Agilent Technologies Inc. Method for synthesizing a specific, surface-bound polymer uniformly over an element of a molecular array
US20020110809A1 (en) * 1999-04-30 2002-08-15 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
WO2000066743A2 (en) 1999-05-04 2000-11-09 Large Scale Biology Corporation Viral expression vectors
US6395559B1 (en) * 1999-05-04 2002-05-28 Orchid Biosciences, Inc. Multiple fluid sample processor with single well addressability
US20020095031A1 (en) * 1999-05-04 2002-07-18 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
WO2000066259A1 (en) * 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
DE19922941A1 (de) * 1999-05-14 2000-11-30 Epigenomics Gmbh Vorrichtung und Verfahren zur photolithographischen Belichtung von biologischen Stoffen
JP3957118B2 (ja) * 1999-05-18 2007-08-15 富士フイルム株式会社 試験片およびこの試験片からの画像情報読取装置
ES2185592T5 (es) 1999-05-19 2009-03-01 Eppendorf Array Technologies Procedimiento para la identificacion y/o cuantificacion de un compuesto diana.
US6638717B2 (en) 1999-05-19 2003-10-28 Aventis Pharmaceuticals, Inc. Microarray-based subtractive hybridzation
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
JP2003500070A (ja) 1999-05-21 2003-01-07 インビトロゲン・コーポレーション 核酸分子を標識するための組成物および方法
US6472141B2 (en) 1999-05-21 2002-10-29 Caliper Technologies Corp. Kinase assays using polycations
US6287774B1 (en) * 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
CN1159454C (zh) * 1999-05-21 2004-07-28 陆祖宏 制备化合物微阵列芯片的方法及由该方法制备的化合物微阵列芯片
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US6371370B2 (en) * 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
US6502039B1 (en) 2000-05-24 2002-12-31 Aventis Pharmaceuticals Mathematical analysis for the estimation of changes in the level of gene expression
DK1190366T3 (da) 1999-05-25 2006-02-27 Aventis Pharma Inc Matematisk analyse til estimering af ændringer i genekspressionsniveauet
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6132686A (en) * 1999-05-28 2000-10-17 Mettler-Toledo Bohdan, Inc. Pressurized reaction block
WO2000075644A1 (de) * 1999-06-05 2000-12-14 Zeptosens Ag Sensorplatform und verfahren zur multianalytbestimmung
KR20010001577A (ko) 1999-06-07 2001-01-05 윤종용 고분자 광산발생제를 이용한 올리고펩티드 핵산 탐침의 제조방법
US6660479B2 (en) 1999-06-07 2003-12-09 Samsung Electronics Co., Ltd. Process for preparing peptide nucleic acid probe using polymeric photoacid generator
US6716579B1 (en) 1999-06-11 2004-04-06 Narayan Baidya Gene specific arrays, preparation and use
US7485715B2 (en) * 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
AU5882000A (en) 1999-06-22 2001-01-09 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
KR100379411B1 (ko) 1999-06-28 2003-04-10 엘지전자 주식회사 바이오칩 및 그의 생체 물질 패터닝 및 측정 방법
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6399394B1 (en) 1999-06-30 2002-06-04 Agilent Technologies, Inc. Testing multiple fluid samples with multiple biopolymer arrays
US6258593B1 (en) 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
ATE323113T1 (de) * 1999-07-02 2006-04-15 Symyx Technologies Inc Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
EP1192448B1 (en) 1999-07-05 2006-09-27 Novartis AG Process of using a sensor platform
US7223364B1 (en) 1999-07-07 2007-05-29 3M Innovative Properties Company Detection article having fluid control film
US6964847B1 (en) 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US7013221B1 (en) 1999-07-16 2006-03-14 Rosetta Inpharmatics Llc Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays
US7371516B1 (en) 1999-07-16 2008-05-13 Rosetta Inpharmatics Llc Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
US7479555B2 (en) * 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
US6692915B1 (en) 1999-07-22 2004-02-17 Girish N. Nallur Sequencing a polynucleotide on a generic chip
US7144700B1 (en) * 1999-07-23 2006-12-05 Affymetrix, Inc. Photolithographic solid-phase polymer synthesis
DE19935749C2 (de) * 1999-07-28 2003-06-26 Epigenomics Ag Verfahren zur Chrakterisierung von Nukleinsäurefragmenten
US6864050B2 (en) * 1999-07-30 2005-03-08 Affymetrix, Inc. Single-phase amplification of nucleic acids
AU775380B2 (en) * 1999-08-18 2004-07-29 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
AU2246601A (en) 1999-08-30 2001-04-10 Illumina, Inc. Methods for improving signal detection from an array
US20050118618A1 (en) * 1999-08-30 2005-06-02 Dale Roderic M. Method for detecting nucleic acid sequences
ATE342271T1 (de) 1999-08-30 2006-11-15 Roche Diagnostics Gmbh 2-azapurine verbindungen und ihre verwendung
CA2317179A1 (en) * 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US6448388B1 (en) 2000-08-16 2002-09-10 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
US20080003673A1 (en) * 1999-09-02 2008-01-03 Alejandro Abuin Novel human proteases and polynucleotides encoding the same
US20020165376A1 (en) * 1999-12-22 2002-11-07 Walke D. Wade Novel human proteases and polynucleotides encoding the same
US20030050464A1 (en) * 2000-07-28 2003-03-13 Yi Hu Novel human proteases and polynucleotides encoding the same
US6716614B1 (en) 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US20050153323A1 (en) * 2000-07-28 2005-07-14 Yi Hu Novel human proteases and polynucleotides encoding the same
US6395483B1 (en) * 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
DK1210357T3 (da) 1999-09-10 2008-07-21 Geron Corp Oligonukleotid-N3' -P5' -thiophosphoramidater: syntese og anvendelse deraf
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
FR2798392B1 (fr) * 1999-09-13 2005-07-15 Exonhit Therapeutics Sa Marqueurs genetiques de la toxicite, preparation et utilisations
US6319674B1 (en) 1999-09-16 2001-11-20 Agilent Technologies, Inc. Methods for attaching substances to surfaces
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6743585B2 (en) 1999-09-16 2004-06-01 Agilent Technologies, Inc. Methods for preparing conjugates
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
EP1218529B1 (en) 1999-09-17 2006-11-22 Whitehead Institute For Biomedical Research Reverse transfection method
US7078167B2 (en) * 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
US20020006664A1 (en) * 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto
US7122303B2 (en) 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
US6790660B1 (en) * 2001-09-18 2004-09-14 Lexicon Genetics Incorporated Human kielin-like proteins and polynucleotides encoding the same
US20020107382A1 (en) * 2000-09-27 2002-08-08 Friddle Carl Johan Novel human protease inhibitor proteins and polynucleotides encoding the same
US6867291B1 (en) * 2000-09-15 2005-03-15 Lexicon Genetics Incorporated Human hemicentin proteins and polynucleotides encoding the same
US6797510B1 (en) * 2001-05-24 2004-09-28 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6586230B1 (en) * 2000-10-27 2003-07-01 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6864079B2 (en) 2001-04-06 2005-03-08 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6841377B1 (en) * 2001-06-13 2005-01-11 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6511840B1 (en) 2000-06-15 2003-01-28 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US20080050809A1 (en) * 1999-09-28 2008-02-28 Alejandro Abuin Novel human kinases and polynucleotides encoding the same
US6673536B1 (en) 1999-09-29 2004-01-06 Rosetta Inpharmatics Llc. Methods of ranking oligonucleotides for specificity using wash dissociation histories
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
WO2001023426A2 (en) * 1999-09-30 2001-04-05 Varian Associates, Inc. Hypoxia-related human genes, proteins, and uses thereof
KR20020048425A (ko) * 1999-09-30 2002-06-22 해리 제이. 레온 하르트 마이크로전자 어레이 상의 생체분자 부착 부위
US7217573B1 (en) 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
CA2386791A1 (en) * 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US20080213878A1 (en) * 1999-10-19 2008-09-04 Gregory Donoho Novel human membrane proteins and polynucleotides encoding the same
US20030013865A1 (en) * 2001-03-12 2003-01-16 Yu Xuanchuan (Sean) Novel human EGF-family proteins and polynucleotides encoding the same
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US7364920B2 (en) * 1999-10-27 2008-04-29 Technion Research And Development Foundation Ltd. Method for gold deposition
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
CA2388595C (en) 1999-10-27 2010-12-21 Biowulf Technologies, Llc Methods and devices for identifying patterns in biological systems and methods for uses thereof
KR100339379B1 (ko) 1999-10-29 2002-06-03 구자홍 바이오칩과 그의 생체 물질 측정장치 및 측정방법
US6329210B1 (en) * 1999-10-29 2001-12-11 Agilent Technologies, Inc. Method and apparatus for high volume polymer synthesis
US8153367B2 (en) * 1999-10-29 2012-04-10 Perkinelmer Las, Inc. Amplified array analysis system
US6689319B1 (en) 1999-10-29 2004-02-10 Agilent Technologies, Ind. Apparatus for deposition and inspection of chemical and biological fluids
WO2001032935A2 (en) * 1999-11-02 2001-05-10 Celine Hu Molecular microarrays and methods for production and use thereof
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6642046B1 (en) * 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
US6589778B1 (en) 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US7041445B2 (en) 1999-11-15 2006-05-09 Clontech Laboratories, Inc. Long oligonucleotide arrays
AU1777401A (en) * 1999-11-17 2001-05-30 Xiuli Chen Simultaneous detection of hbv, hcv and hiv in plasma samples using a multiplex capture assay
US6583399B1 (en) 1999-11-22 2003-06-24 California Institute Of Technology Optical resonator microsphere sensor with altering Q-factor
US6446642B1 (en) 1999-11-22 2002-09-10 Agilent Technologies, Inc. Method and apparatus to clean an inkjet reagent deposition device
AU4507201A (en) 1999-11-24 2001-06-18 Incyte Genomics, Inc. Normalization controls and duplex probes for hybridization reactions
US6423535B1 (en) 1999-11-24 2002-07-23 Incyte Genomics, Inc. Normalization control for hybridization reactions
WO2001038585A2 (en) 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
US6703480B1 (en) 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
CA2392534A1 (en) 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population
GB9928787D0 (en) 1999-12-03 2000-02-02 Medical Res Council Direct screening method
GB9928789D0 (en) * 1999-12-03 2000-02-02 Medical Res Council Naive screening method
CA2393332A1 (en) 1999-12-07 2001-06-14 Lexicon Genetics Incorporated Novel human kinase proteins and polynucleotides encoding the same
JP2003527838A (ja) * 1999-12-07 2003-09-24 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト膜タンパクおよびそれをコードするポリヌクレオチド
AU784486B2 (en) 1999-12-09 2006-04-13 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
WO2001042786A2 (en) 1999-12-09 2001-06-14 Cellomics, Inc. System for cell based screening : cell spreading
US6482638B1 (en) * 1999-12-09 2002-11-19 3M Innovative Properties Company Heat-relaxable substrates and arrays
EP2210948A3 (en) 1999-12-10 2010-10-06 Life Technologies Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
AU784376B2 (en) * 1999-12-13 2006-03-23 Lexicon Pharmaceuticals, Inc. Novel human transferase proteins and polynucleotides encoding the same
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
US6406840B1 (en) 1999-12-17 2002-06-18 Biomosaic Systems, Inc. Cell arrays and the uses thereof
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US20020197656A1 (en) * 1999-12-17 2002-12-26 Ronghao Li Cell arrays and the uses thereof
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6670124B1 (en) 1999-12-20 2003-12-30 Stemcyte, Inc. High throughput methods of HLA typing
CA2395247A1 (en) * 1999-12-22 2001-06-28 Lexicon Genetics Incorporated Novel human membrane proteins and polynucleotides encoding the same
DE19962803A1 (de) * 1999-12-23 2001-07-05 Basf Ag Verfahren und Vorrichtung zur maskenfreien Herstellung von Biopolymeren
US6929907B2 (en) 1999-12-31 2005-08-16 North Carolina State University Methods and compositions for determining the purity of chemically synthesized nucleic acids
US6800439B1 (en) 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
CA2402360A1 (en) * 2000-01-06 2001-07-12 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
US6977723B2 (en) * 2000-01-07 2005-12-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
US20050118637A9 (en) * 2000-01-07 2005-06-02 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
JP2003519698A (ja) * 2000-01-07 2003-06-24 トランスフォーム ファーマスーティカルズ,インコーポレイテッド 多様な固体形態のハイスループットでの形成、同定および分析
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US7108970B2 (en) * 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
DE10000629C5 (de) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Verfahren zur Identifizierung einer auf einen festen Körper aufgebrachten Markierung
WO2001051634A1 (en) * 2000-01-12 2001-07-19 Lexicon Genetics Incorporated Human olfactory receptor and polynucleotides encoding the same
JP2003523187A (ja) * 2000-01-18 2003-08-05 レキシコン・ジェネティクス・インコーポレーテッド ヒト膜gaba受容体タンパクおよびそれをコードするポリヌクレオチド
JP2004504804A (ja) * 2000-01-18 2004-02-19 レキシコン・ジェネティクス・インコーポレーテッド ヒト新規キナーゼタンパクおよびそれをコードするポリヌクレオチド
WO2003074738A1 (en) * 2000-01-18 2003-09-12 Quantom Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US6728641B1 (en) 2000-01-21 2004-04-27 General Electric Company Method and system for selecting a best case set of factors for a chemical reaction
US7429466B2 (en) * 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US8143195B2 (en) * 2000-01-24 2012-03-27 Yingjian Wang Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
US20030097222A1 (en) * 2000-01-25 2003-05-22 Craford David M. Method, system, and computer software for providing a genomic web portal
AU2001253117B8 (en) * 2000-01-26 2006-08-03 Lexicon Pharmaceuticals, Inc. Human neurexin-like proteins and polynucleotides encoding the same
EP1257664A4 (en) * 2000-01-28 2006-04-05 Althea Technologies Inc METHOD FOR THE ANALYSIS OF GENE EXPRESSION
WO2001055451A1 (en) 2000-01-28 2001-08-02 Linden Technologies, Inc. C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support
WO2001094566A2 (en) * 2000-01-28 2001-12-13 Lexicon Genetics Incorporated Human enzymes and polynucleotides encoding the same
WO2001055394A1 (en) * 2000-01-28 2001-08-02 Lexicon Genetics Incorporated Human membrane proteins and polynucleotides encoding the same
GB0002389D0 (en) * 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
WO2001056955A1 (en) * 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Nonredundant split/pool synthesis of combinatorial libraries
WO2001057220A2 (en) * 2000-02-04 2001-08-09 Lexicon Genetics Incorporated Human enzymes and polynucleotides encoding the same
WO2001057086A2 (en) * 2000-02-04 2001-08-09 Lexicon Genetics Incorporated Novel human g protein coupled receptor proteins and polynucleotides encoding the same
DK1259643T3 (da) * 2000-02-07 2009-02-23 Illumina Inc Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US6693033B2 (en) 2000-02-10 2004-02-17 Motorola, Inc. Method of removing an amorphous oxide from a monocrystalline surface
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
CA2399876A1 (en) 2000-02-11 2001-08-16 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
US20030176385A1 (en) * 2000-02-15 2003-09-18 Jingfang Ju Antisense modulation of protein expression
AU2001238503A1 (en) 2000-02-17 2001-08-27 Lexicon Genetics Incorporated Novel human thrombospondin repeat proteins and polynucleotides encoding the same
US20020151040A1 (en) * 2000-02-18 2002-10-17 Matthew O' Keefe Apparatus and methods for parallel processing of microvolume liquid reactions
WO2001061054A2 (en) 2000-02-18 2001-08-23 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US20020164643A1 (en) * 2000-02-18 2002-11-07 Aspira Biosystems, Inc. Compositions and methods for surface imprinting
CA2399189A1 (en) 2000-02-22 2001-08-30 Genospectra, Inc. Microarray fabrication techniques and apparatus
US6515131B2 (en) 2000-02-22 2003-02-04 Biostream Therapeutics, Inc. Imagining agents for diagnosis of Parkinson's disease
US6594432B2 (en) 2000-02-22 2003-07-15 Genospectra, Inc. Microarray fabrication techniques and apparatus
US20040014102A1 (en) * 2000-02-22 2004-01-22 Shiping Chen High density parallel printing of microarrays
JP2003524193A (ja) 2000-02-23 2003-08-12 ザイオミックス インコーポレイテッド 高い位置に配置されたサンプル表面を有するチップ
WO2001064903A2 (en) * 2000-02-29 2001-09-07 Lexicon Genetics Incorporated Novel human transferase proteins and polynucleotides encoding the same
CA2401645A1 (en) * 2000-02-29 2001-09-07 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
US6627571B1 (en) 2000-03-01 2003-09-30 Symyx Technologies, Inc. Method and system for the situ synthesis of a combinatorial library of supported catalyst materials
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
AU2001240040A1 (en) * 2000-03-03 2001-09-17 California Institute Of Technology Combinatorial array for nucleic acid analysis
US20020082405A1 (en) * 2000-03-06 2002-06-27 Gregory Donoho Novel human transporter proteins and polynucleotides encoding the same
DE10011022A1 (de) * 2000-03-07 2001-09-27 Meinhard Knoll Vorrichtung und Verfahren zur Durchführung von Synthesen, Analysen oder Transportvorgängen
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
AU4352101A (en) 2000-03-10 2001-09-24 Lexicon Genetics Inc Novel human g-coupled protein receptor kinases and polynucleotides encoding the same
AU4739501A (en) * 2000-03-13 2001-09-24 Lexicon Genetics Inc Novel human phospholipases and polynucleotides encoding the same
US6489160B2 (en) 2000-03-16 2002-12-03 Kabushiki Kaisha Toshiba Method for producing nucleic acid strand immobilized carrier
US6806361B1 (en) 2000-03-17 2004-10-19 Affymetrix, Inc. Methods of enhancing functional performance of nucleic acid arrays
US20050119473A1 (en) * 2000-03-17 2005-06-02 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
US6833450B1 (en) 2000-03-17 2004-12-21 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
EP1268538A2 (en) * 2000-03-20 2003-01-02 Lexicon Genetics Incorporated Human secreted proteins and polynucleotides encoding the same
CA2403708A1 (en) 2000-03-22 2001-09-27 Quantum Dot Corporation Methods of using semiconductor nanocrystals in bead-based nucleic acid assays
US6413722B1 (en) 2000-03-22 2002-07-02 Incyte Genomics, Inc. Polymer coated surfaces for microarray applications
US7875442B2 (en) * 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
WO2006053769A1 (en) 2004-11-18 2006-05-26 Eppendorf Array Technologies Real-time quantification of multiple targets on a micro-array
US7829313B2 (en) * 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US20080085515A1 (en) * 2000-03-24 2008-04-10 Eppendorf Array Technologies Sa (Eat) Identification of multiple biological (micro) organisms by detection of their nucleotide sequences on arrays
US7202026B2 (en) * 2000-03-24 2007-04-10 Eppendorf Array Technologies Sa (Eat) Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array
US7244572B1 (en) * 2000-03-24 2007-07-17 Wisys Technology Foundation, Inc. One-dimensional arrays on optical fibers
US7205104B2 (en) 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
US20020012931A1 (en) 2000-03-27 2002-01-31 Waldman Scott A. High specificity marker detection
US6884578B2 (en) * 2000-03-31 2005-04-26 Affymetrix, Inc. Genes differentially expressed in secretory versus proliferative endometrium
US20020081597A1 (en) * 2000-03-31 2002-06-27 Genentech, Inc. Compositions and methods for detecting and quantifying gene expression
CA2404896A1 (en) 2000-04-03 2001-10-11 Lexicon Genetics Incorporated Human ion channel protein and polynucleotides encoding the same
US7157564B1 (en) 2000-04-06 2007-01-02 Affymetrix, Inc. Tag nucleic acids and probe arrays
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
EP1272644A1 (en) * 2000-04-12 2003-01-08 Lexicon Genetics Incorporated Human metalloprotease and polynucleotides encoding the same
US20030108291A1 (en) * 2000-04-14 2003-06-12 Duveneck Gert Ludwig Grid-waveguide structure for reinforcing an excitation field and use thereof
US20020009740A1 (en) 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
JP5508654B2 (ja) 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
US6983233B1 (en) 2000-04-19 2006-01-03 Symyx Technologies, Inc. Combinatorial parameter space experiment design
US6667287B2 (en) * 2000-04-20 2003-12-23 Colgate-Palmolive Company Light duty cleaning composition comprising an amine oxide and polyacrylic acid homopolymer
AU2001257195B2 (en) 2000-04-25 2006-10-05 Lexicon Pharmaceuticals, Inc. Novel human kinase proteins and polynucleotides encoding the same
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
WO2001084242A1 (en) 2000-05-03 2001-11-08 Caliper Technologies Corp. Multi depth substrate fabrication processes
US8399383B2 (en) 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
US6690467B1 (en) 2000-05-05 2004-02-10 Pe Corporation Optical system and method for optically analyzing light from a sample
WO2001086591A2 (en) * 2000-05-08 2001-11-15 General Electric Company High throughput screening method and system
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6709840B1 (en) 2000-05-11 2004-03-23 The Board Of Trustees Of The Leland Stanford Junior University Anergy associated genes
WO2001088134A2 (en) * 2000-05-12 2001-11-22 Lexicon Genetics Incorporated Novel human lipocalin homologs and polynucleotides encoding the same
US20020110843A1 (en) * 2000-05-12 2002-08-15 Dumas David P. Compositions and methods for epitope mapping
US6492458B1 (en) 2000-05-16 2002-12-10 Arizona Chemical Company Polyalkyleneoxydiamine polyamides useful for formulating inks for phase-change jet printing
WO2001088133A2 (en) * 2000-05-18 2001-11-22 Lexicon Genetics Incorporated Human semaphorin homologs and polynucleotides encoding the same
AU2001274923A1 (en) * 2000-05-23 2001-12-03 Lexicon Genetics Incorporated Novel human thrombospondin-like proteins and polynucleotides encoding the same
US6686188B2 (en) * 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US6656700B2 (en) * 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6790667B1 (en) * 2000-05-30 2004-09-14 Lexicon Genetics Incorporated Human mitochondrial proteins and polynucleotides encoding the same
US20020155471A1 (en) * 2000-05-31 2002-10-24 Nicolette Charles A. Compounds for therapy and diagnosis and methods for using same
US7005259B1 (en) 2000-06-01 2006-02-28 Affymetrix, Inc. Methods for array preparation using substrate rotation
JP4644914B2 (ja) * 2000-06-02 2011-03-09 株式会社村田製作所 プローブアレイ用固相基材、およびプローブアレイ
US6994827B2 (en) 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6703495B2 (en) * 2000-06-07 2004-03-09 Lexicon Genetics Incorporated Polynucleotides encoding human transporter protein
EP1162450A1 (en) * 2000-06-07 2001-12-12 F. Hoffmann-La Roche Ag Reference device for evaluating the performance of a confocal laser scanning microscope, and a method and system for performing that evaluation
US20040168209A1 (en) * 2000-06-12 2004-08-26 Alejandro Abuin Novel murine polynucleotide sequences and mutant cells and mutant animals defined thereby
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
AU2001268468A1 (en) 2000-06-13 2001-12-24 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
EP1164201A1 (en) * 2000-06-14 2001-12-19 Facultés Universitaires Notre-Dame de la Paix Reverse detection for identification and/or quantification of nucleotide target sequences on biochips
US20060166227A1 (en) * 2000-06-20 2006-07-27 Stephen Kingsmore Protein expression profiling
AU2001272993B2 (en) 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE60141087D1 (de) * 2000-06-26 2010-03-04 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
AU7151601A (en) * 2000-06-27 2002-01-08 Lexicon Genetics Inc Novel human gaba receptors and polynucleotides encoding the same
US6323009B1 (en) * 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
DE10031587A1 (de) * 2000-06-29 2002-01-10 Basf Ag Dosierung von Suspensionen im Mikromaßstab zur Herstellung von Materialproben in der kombinatorischen Materialforschung sowie deren Prüfung
CA2415258A1 (en) * 2000-07-03 2002-01-10 Xeotron Corporation Devices and methods for carrying out chemical reactions using photogenerated reagents
US20030118486A1 (en) * 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
US20030219816A1 (en) * 2001-07-02 2003-11-27 Keith Solomon Composite microarray slides
WO2002002740A2 (en) * 2000-07-05 2002-01-10 Rosetta Inpharmatics, Inc. Methods and compositions for determining gene function
AU2001271893A1 (en) * 2000-07-07 2002-01-21 Nimblegen Systems, Inc. Method and apparatus for synthesis of arrays of dna probes
US6913879B1 (en) * 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6511277B1 (en) * 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6380377B1 (en) 2000-07-14 2002-04-30 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US7052659B1 (en) * 2000-07-18 2006-05-30 General Electric Company Sequential high throughput screening method and system
US7091033B2 (en) * 2000-07-21 2006-08-15 Phase-1 Molecular Toxicology, Inc. Array of toxicologically relevant canine genes and uses thereof
AU2002224553A1 (en) * 2000-07-21 2002-02-05 Incyte Genomics, Inc. Human proteases
US6555946B1 (en) 2000-07-24 2003-04-29 Motorola, Inc. Acoustic wave device and process for forming the same
US6590236B1 (en) 2000-07-24 2003-07-08 Motorola, Inc. Semiconductor structure for use with high-frequency signals
US6887685B1 (en) * 2000-07-25 2005-05-03 Lexicon Genetics Incorporated Human thymosin protein and polynucleotides encoding the same
DE10036174B4 (de) * 2000-07-25 2006-12-07 Axaron Bioscience Ag Verfahren und Vorrichtung zum Analysieren von chemischen oder biologischen Proben
DE10036457A1 (de) * 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
EP1354031A2 (en) * 2000-07-31 2003-10-22 Maxygen, Inc. Nucleotide incorporating enzymes
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20050181421A1 (en) * 2000-08-03 2005-08-18 Affymetrix, Inc. Methods of array synthesis
CA2418271A1 (en) 2000-08-03 2002-07-04 Perlegen Sciences High performance substrate scanning
ATE384731T1 (de) * 2000-08-03 2008-02-15 Hoffmann La Roche Nukleinsäurebindende verbindungen mit pyrazolo 3, 4-d pyrimidinanalogen von purin-2,6-diamin und ihre verwendung
US8463718B2 (en) * 2000-08-07 2013-06-11 Health Discovery Corporation Support vector machine-based method for analysis of spectral data
US6422249B1 (en) 2000-08-10 2002-07-23 Affymetrix Inc. Cartridge washing system and methods
AU2001284896A1 (en) 2000-08-14 2002-02-25 Surface Logix, Inc. Deformable stamp for patterning three-dimensional surfaces
AU2002245009B2 (en) * 2000-08-15 2007-05-17 Bioforce Nanoscience, Inc. Nanoscale molecular arrayer
US20020076780A1 (en) * 2000-08-16 2002-06-20 Turner C. Alexander Novel human ion channel proteins and polynucleotides encoding the same
US20050106621A1 (en) * 2000-08-16 2005-05-19 Winegarden Neil A. Devices and methods for producing microarrays of biological samples
US6902702B1 (en) 2000-08-16 2005-06-07 University Health Network Devices and methods for producing microarrays of biological samples
ATE375804T1 (de) 2000-08-17 2007-11-15 Tripep Ab Ribavirin-enthaltende vakzine
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
CA2388064A1 (en) 2000-08-22 2002-05-02 Affymetrix, Inc. System method, and computer software product for controlling biological microarray scanner
US7062092B2 (en) 2000-08-22 2006-06-13 Affymetrix, Inc. System, method, and computer software product for gain adjustment in biological microarray scanner
EP1311690B1 (en) * 2000-08-22 2006-07-26 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
AU2001286792A1 (en) * 2000-08-22 2002-03-04 Lexicon Genetics Incorporated Novel human 7TM proteins and polynucleotides encoding the same
EP1387894A4 (en) * 2000-08-24 2006-10-11 Aviva Biosciences Corp METHODS AND COMPOSITIONS FOR IDENTIFYING NUCLEIC ACID MOLECULES USING NUCLEOLYTIC ACTIVITIES AND HYBRIDIZATION
US6900013B1 (en) 2000-08-25 2005-05-31 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
US20020055112A1 (en) * 2000-08-26 2002-05-09 Nila Patil Methods for reducing complexity of nucleic acid samples
US20020164634A1 (en) * 2000-08-26 2002-11-07 Perlegen Sciences, Inc. Methods for reducing complexity of nucleic acid samples
AU2001285326A1 (en) * 2000-08-31 2002-03-13 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
JP2002071687A (ja) * 2000-08-31 2002-03-12 Canon Inc 変異遺伝子のスクリーニング方法
US20030190612A1 (en) * 2000-08-31 2003-10-09 Nobuko Yamamoto Detecting method and detection substrate for use therein
JP3467004B2 (ja) * 2000-08-31 2003-11-17 キヤノン株式会社 核酸の塩基配列の解析方法
WO2002020753A2 (en) * 2000-09-01 2002-03-14 Lexicon Genetics Incorporated Human gaba transporter protein and polynucleotides encoding the same
EP1327135B1 (de) * 2000-09-04 2010-02-24 Bayer Technology Services GmbH System und verfahren zur multianalytbestimmung
US7108969B1 (en) 2000-09-08 2006-09-19 Affymetrix, Inc. Methods for detecting and diagnosing oral cancer
CA2421732A1 (en) * 2000-09-11 2002-03-14 Affymetrix, Inc. Photocleavable protecting groups
US20030176344A1 (en) * 2000-09-14 2003-09-18 Decode Genetics Ehf. Human osteoporosis gene
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
WO2002022885A1 (en) * 2000-09-18 2002-03-21 Thomas Jefferson University Compositions and methods for identifying and targeting stomach and esophageal cancer cells
US20020133299A1 (en) * 2000-09-20 2002-09-19 Jacob Howard J. Physiological profiling
US6420178B1 (en) 2000-09-20 2002-07-16 General Electric Company High throughput screening method, array assembly and system
US6780648B1 (en) 2000-09-20 2004-08-24 General Electric Company Method and system for selectively distributing luminescence material precursors
US20030044803A1 (en) * 2000-09-22 2003-03-06 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of JAK1
US20020164576A1 (en) * 2000-09-22 2002-11-07 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of Nrf2
US7354721B2 (en) * 2000-09-22 2008-04-08 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods, and kits and systems for practicing the same
US20020115058A1 (en) * 2000-09-22 2002-08-22 Pedersen Finn Skou Methods for diagnosis and treatment of diseases associated with altered expression of Pik3r1
US20020037359A1 (en) * 2000-09-25 2002-03-28 Mutz Mitchell W. Focused acoustic energy in the preparation of peptide arrays
US6613285B1 (en) 2000-09-25 2003-09-02 General Electric Company Reactor plate and method
US6806051B2 (en) * 2000-09-25 2004-10-19 Picoliter Inc. Arrays of partially nonhybridizing oligonucleotides and preparation thereof using focused acoustic energy
US6808934B2 (en) 2000-09-25 2004-10-26 Picoliter Inc. High-throughput biomolecular crystallization and biomolecular crystal screening
WO2002024325A2 (en) 2000-09-25 2002-03-28 Picoliter, Inc. Acoustic ejection of fluids from a plurality of reservoirs
US6493497B1 (en) 2000-09-26 2002-12-10 Motorola, Inc. Electro-optic structure and process for fabricating same
ATE326533T1 (de) * 2000-09-27 2006-06-15 Lexicon Genetics Inc Menschliche ionenaustauschproteine und dafür kodierende polynukleotiden
US6780584B1 (en) * 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6496250B1 (en) 2000-09-29 2002-12-17 General Electric Company Combinatorial method foe development of optical ceramics
CN100495030C (zh) * 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
US6638838B1 (en) 2000-10-02 2003-10-28 Motorola, Inc. Semiconductor structure including a partially annealed layer and method of forming the same
US6777232B1 (en) * 2000-10-02 2004-08-17 Lexicon Genetics Incorporated Human membrane proteins and polynucleotides encoding the same
US20020123474A1 (en) * 2000-10-04 2002-09-05 Shannon Mark E. Human GTP-Rho binding protein2
US20040091602A1 (en) * 2000-10-04 2004-05-13 Hwang Hyun Jin Method for immobilizing biologically active molecules
US20100261159A1 (en) * 2000-10-10 2010-10-14 Robert Hess Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
AU2002213183A1 (en) 2000-10-12 2002-04-22 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6849409B2 (en) * 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
US7001763B1 (en) 2000-10-17 2006-02-21 Lexicon Genetics Incorporated Human semaphorin proteins and polynucleotides encoding the same
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
JPWO2002033068A1 (ja) * 2000-10-18 2004-02-26 キヤノン株式会社 核酸の塩基配列の解析方法
JP2004537712A (ja) * 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US20020155476A1 (en) * 2000-10-20 2002-10-24 Nader Pourmand Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
US6861214B1 (en) * 2000-10-23 2005-03-01 Beckman Coulter, Inc. Immobilization of biopolymers to aminated substrates by direct adsorption
DE10052823B4 (de) * 2000-10-24 2014-11-20 Ruprecht-Karls-Universität Heidelberg Verfahren zur lichtmikroskopischen Analyse der Topologie molekularer Strukturen in Rasteranordnungen
WO2002037938A2 (en) 2000-10-24 2002-05-16 Oncosis Llc Method and device for selectively targeting cells within a three -dimensional specimen
US6491967B1 (en) 2000-10-24 2002-12-10 General Electric Company Plasma spray high throughput screening method and system
US7118908B2 (en) * 2000-10-25 2006-10-10 Bor-Iuan Jan On-spot selectively activated hydrophobic slide and preparation thereof
EP1203945B1 (en) * 2000-10-26 2006-12-20 Agilent Technologies, Inc. (a Delaware corporation) Microarray
WO2002070705A2 (en) * 2000-10-27 2002-09-12 Lexicon Genetics Incorporated Human 7tm proteins and polynucleotides encoding them
JP2004531209A (ja) * 2000-10-30 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト7tmタンパクおよびそれをコードするポリヌクレオチド
US20020142483A1 (en) 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
DE60122389T2 (de) * 2000-11-01 2007-08-02 Lexicon Genetics Inc., The Woodlands Polynukleotide die für humane meltrin beta (adam19) metalloendopeptidasen kodieren
US6567751B1 (en) 2000-11-03 2003-05-20 General Electric Company Methods and computer system for combinatorial analysis of lighting phosphors
US6803205B2 (en) * 2000-11-08 2004-10-12 Surface Logix, Inc. Methods of measuring enzyme activity using peelable and resealable devices
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US7351575B2 (en) * 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US6937323B2 (en) * 2000-11-08 2005-08-30 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
US7371563B2 (en) * 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US7326563B2 (en) 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US7033821B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
US6864065B2 (en) * 2000-11-08 2005-03-08 Surface Logix, Inc. Assays for monitoring cell motility in real-time
US7033819B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US6893851B2 (en) 2000-11-08 2005-05-17 Surface Logix, Inc. Method for arraying biomolecules and for monitoring cell motility in real-time
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
US7001740B2 (en) * 2000-11-08 2006-02-21 Surface Logix, Inc. Methods of arraying biological materials using peelable and resealable devices
US6967074B2 (en) * 2000-11-08 2005-11-22 Surface Logix, Inc. Methods of detecting immobilized biomolecules
US20020150887A1 (en) * 2000-11-09 2002-10-17 National Institute Of Advanced Industrial Science And Technology Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
US7061594B2 (en) * 2000-11-09 2006-06-13 Burstein Technologies, Inc. Disc drive system and methods for use with bio-discs
JP2004535154A (ja) * 2000-11-15 2004-11-25 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト分泌タンパク質およびそれをコードするポリヌクレオチド
WO2002044695A1 (en) * 2000-11-16 2002-06-06 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US7378280B2 (en) 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) * 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
WO2002042438A2 (en) * 2000-11-20 2002-05-30 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6905816B2 (en) * 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
EP1415005B1 (en) 2000-12-07 2012-11-21 Novartis Vaccines and Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
WO2002046762A2 (en) * 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical disc assemblies for performing assays
JP3778041B2 (ja) * 2000-12-08 2006-05-24 コニカミノルタホールディングス株式会社 粒子分離機構及び粒子分離装置
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
JP2004517622A (ja) 2000-12-11 2004-06-17 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼ及び該キナーゼをコードするポリヌクレオチド
WO2002048333A2 (en) * 2000-12-12 2002-06-20 Lexicon Genetics Incorporated Novel human kinases and uses thereof
US6596239B2 (en) * 2000-12-12 2003-07-22 Edc Biosystems, Inc. Acoustically mediated fluid transfer methods and uses thereof
EP1427847B1 (en) * 2000-12-13 2010-07-28 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
CA2431066C (en) * 2000-12-15 2007-05-15 Youqi Wang Methods and apparatus for designing high-dimensional combinatorial experiments
US6583269B1 (en) * 2000-12-18 2003-06-24 Lexicon Genetics Incorporated Human protease inhibitor and polynucleotides encoding the same
US6448387B1 (en) * 2000-12-18 2002-09-10 Monsanto Technology, Llc Polymeric arrays adapted for high expressing polynucleotides
US6852844B1 (en) * 2000-12-20 2005-02-08 Lexicon Genetics Incorporated Human protocadherin proteins and polynucleotides encoding the same
CA2432737A1 (en) * 2000-12-20 2002-06-27 Lexicon Genetics Incorporated Human ion channel protein and polynucleotides encoding the same
US20030165878A1 (en) * 2000-12-22 2003-09-04 Morris David W. Novel compositions and methods in cancer associated with altered expression of MCM3AP
US20030087252A1 (en) * 2000-12-22 2003-05-08 Morris David W. Novel compositions and methods in cancer associated with altered expression of PRDM11
US20030232334A1 (en) 2000-12-22 2003-12-18 Morris David W. Novel compositions and methods for cancer
US20030099963A1 (en) * 2000-12-22 2003-05-29 Morris David W. Novel compositions and methods in cancer associated with altered expression of TBX21
US7820447B2 (en) * 2000-12-22 2010-10-26 Sagres Discovery Inc. Compositions and methods for cancer
US7700274B2 (en) * 2000-12-22 2010-04-20 Sagres Discovery, Inc. Compositions and methods in cancer associated with altered expression of KCNJ9
US7892730B2 (en) * 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US7645441B2 (en) * 2000-12-22 2010-01-12 Sagres Discovery Inc. Compositions and methods in cancer associated with altered expression of PRLR
WO2002052045A1 (en) * 2000-12-26 2002-07-04 Aviva Biosciences Active and biocompatible platforms prepared by polymerization of surface coating films
AU2002246858A1 (en) * 2000-12-27 2002-08-06 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US20020115844A1 (en) * 2001-01-05 2002-08-22 Yu Xuanchuan Sean Novel human lipase and polynucleotides encoding the same
WO2002053754A2 (en) * 2001-01-08 2002-07-11 Lexicon Genetics Incorporated Human protease and polynucleotides encoding the same
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
AU2002241851A1 (en) * 2001-01-11 2002-07-24 Burstein Technologies, Inc. Optical disc analysis system including related methods for biological and medical imaging
US20020150935A1 (en) * 2001-01-12 2002-10-17 Zheng-Zheng Zhou Dotted micro-array data extraction method
PT1385950E (pt) * 2001-01-19 2008-08-12 Centocor Inc Montagem dirigida por computador de um polinucleótido que codifica um polipéptido alvo
JP2004524835A (ja) * 2001-01-23 2004-08-19 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼおよびそれをコードするポリヌクレオチド
EP1360490B1 (en) * 2001-01-23 2011-12-21 President and Fellows of Harvard College Nucleic-acid programmable protein arrays
US20090226915A1 (en) 2001-01-24 2009-09-10 Health Discovery Corporation Methods for Screening, Predicting and Monitoring Prostate Cancer
US6399713B1 (en) 2001-01-24 2002-06-04 Arizona Chemical Company Hydrocarbon-terminated polyether-polyamide block copolymers and uses thereof
US6870011B2 (en) * 2001-01-24 2005-03-22 Arizona Chemical Company Hydrocarbon-terminated polyether-polyamide block copolymers and uses thereof
JP2005502311A (ja) * 2001-01-24 2005-01-27 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトリパーゼ及び該リパーゼをコードするポリヌクレオチド
US20020169562A1 (en) * 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
GB0102357D0 (en) * 2001-01-30 2001-03-14 Randox Lab Ltd Imaging method
US7112305B2 (en) 2001-01-31 2006-09-26 Agilent Technologies, Inc. Automation-optimized microarray package
US7166258B2 (en) * 2001-01-31 2007-01-23 Agilent Technologies, Inc. Automation-optimized microarray package
US20030170148A1 (en) * 2001-01-31 2003-09-11 Mcentee John F. Reaction chamber roll pump
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
WO2002063002A2 (en) * 2001-02-02 2002-08-15 Lexicon Genetics Incorporated Novel human transporter protein and polynucleotides encoding the same
AU2002255515A1 (en) * 2001-02-05 2002-08-19 Board Of Regents, The University Of Texas System The use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
CN1500144A (zh) * 2001-02-06 2004-05-26 �����﹤����ʽ���� 扩增的核酸及其固定化制品
EP1363935B1 (en) * 2001-02-07 2012-11-14 Life Technologies Corporation Ter sites and ter binding proteins
US6832163B2 (en) * 2001-02-09 2004-12-14 Agilent Technologies, Inc. Methods of identifying heterogeneous features in an image of an array
JP2004529623A (ja) * 2001-02-20 2004-09-30 レキシコン・ジェネティクス・インコーポレーテッド 新規プロテアーゼおよびそれをコードするポリヌクレオチド
US20020160527A1 (en) 2001-02-26 2002-10-31 3M Innovative Properties Company Combinatorial library comprising pouches as packages for library members and method therefor
US6673646B2 (en) 2001-02-28 2004-01-06 Motorola, Inc. Growth of compound semiconductor structures on patterned oxide films and process for fabricating same
US20030165873A1 (en) 2001-03-02 2003-09-04 Come Jon H. Three hybrid assay system
EP1236804A1 (en) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh A method for determination of a nucleic acid using a control
AU2002258100B2 (en) 2001-03-02 2007-03-01 University Of Western Ontario Polymer precursors of radiolabeled compounds, and methods of making and using the same
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
JP3929250B2 (ja) * 2001-03-08 2007-06-13 株式会社ルネサステクノロジ 半導体装置
GB0105787D0 (en) * 2001-03-08 2001-04-25 Expresson Biosystems Ltd Complex element micro-array and methods of use
WO2002072773A2 (en) * 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
EP1373573B1 (en) * 2001-03-09 2013-10-02 TrovaGene, Inc. Conjugate probes and optical detection of analytes
KR20030082535A (ko) 2001-03-09 2003-10-22 뉴젠 테크놀로지스 인코포레이티드 Rna 서열의 증폭을 위한 방법 및 조성물
CA2440754A1 (en) 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
AU2002245593A1 (en) * 2001-03-12 2002-09-24 Lexicon Genetics Incorporated Novel human dectin proteins and polynucleotides encoding the same
US20020164627A1 (en) * 2001-03-12 2002-11-07 Wilganowski Nathaniel L. Novel human transporter proteins and polynucleotides encoding the same
AU2002252370A1 (en) * 2001-03-12 2002-09-24 Irm, Llc. Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters
EP1385829A4 (en) * 2001-03-12 2005-10-19 Affymetrix Inc NUCLEIC ACID MARKING COMPOUNDS
US7276580B2 (en) * 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
US20030170642A1 (en) * 2001-03-12 2003-09-11 Irm, Llc Identification of cellular targets for biologically active molecules
WO2002073673A1 (en) 2001-03-13 2002-09-19 Rochester Institute Of Technology A micro-electro-mechanical switch and a method of using and making thereof
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US6994995B1 (en) 2001-03-16 2006-02-07 Lexicon Genetics Incorporated Human synaptotagmin and polynucleotides encoding the same
US20030104410A1 (en) * 2001-03-16 2003-06-05 Affymetrix, Inc. Human microarray
WO2002074932A2 (en) 2001-03-20 2002-09-26 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
AU2002306768A1 (en) * 2001-03-20 2002-10-03 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
FR2822476B1 (fr) 2001-03-23 2004-04-02 Aventis Pharma Sa Procedes de purification et de detection de sequences cibles d'adn double brin par interaction triple helice
US6855501B2 (en) * 2001-03-26 2005-02-15 Linden Technologies, Inc. Transfer of arrayed chemical compositions
US20020136772A1 (en) * 2001-03-26 2002-09-26 Tai-Nang Huang Polymer synthesis
US7419958B2 (en) 2001-03-26 2008-09-02 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
US6596489B2 (en) 2001-03-30 2003-07-22 Applied Gene Technologies Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
AU785425B2 (en) * 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US7115726B2 (en) * 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
US7514263B2 (en) 2001-04-02 2009-04-07 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of materials
AU2002257671A1 (en) * 2001-04-02 2002-10-15 Zeptosens Ag Optical structure for multi-photon excitation and the use thereof
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
EP1383879A4 (en) * 2001-04-06 2005-05-11 Lexicon Genetics Inc HUMAN KINASES AND POLYNUCLEOTIDES ENCODING SAME
US20060129329A1 (en) * 2001-04-09 2006-06-15 Kobylecki Ryszard J Investigating different physical and/or chemical forms of materials
EP1385627A1 (en) * 2001-04-09 2004-02-04 David P. Dumas Transparent polymer support for organic synthesis
JP3885511B2 (ja) * 2001-04-11 2007-02-21 ソニー株式会社 レーザー光発生装置及び方法
EP1493014A2 (en) 2001-04-11 2005-01-05 Burstein Technologies, Inc. Multi-parameter assays including analysis discs and methods relating thereto
US6644173B2 (en) * 2001-04-11 2003-11-11 Keuring, Incorporated Beverage filter cartridge holder
US6607895B2 (en) 2001-04-16 2003-08-19 Lexicon Genetics Incorporated Human adenylsuccinate synthetase and polynucleotides encoding the same
EP1390526A4 (en) 2001-04-18 2005-02-02 Perlegen Sciences Inc METHOD FOR IDENTIFYING THE EVOLUTIONARY PRESERVED SEQUENCES
US7258974B2 (en) * 2001-04-23 2007-08-21 Michael F. Chou Transcription factor network discovery methods
US6650411B2 (en) 2001-04-26 2003-11-18 Affymetrix, Inc. System, method, and product for pixel clocking in scanning of biological materials
US6643015B2 (en) 2001-04-26 2003-11-04 Affymetrix, Inc. System, method, and product for symmetrical filtering in scanning of biological materials
US6490533B2 (en) * 2001-04-26 2002-12-03 Affymetrix, Inc. System, method, and product for dynamic noise reduction in scanning of biological materials
US20020160427A1 (en) * 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes
EP1385999B1 (en) * 2001-04-30 2012-12-12 Ventana Medical Systems, Inc. Reagents and methods for automated in situ or microarray hybridization
WO2002088313A2 (en) * 2001-04-30 2002-11-07 Lexicon Genetics Incorporated Novel human nuclear transporters and polynucleotides encoding the same
US7138506B2 (en) * 2001-05-09 2006-11-21 Genetic Id, Na, Inc. Universal microarray system
CA2446967A1 (en) * 2001-05-09 2002-11-14 Lexicon Genetics Incorporated Novel human kinases and polynucleotides encoding the same
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US6989276B2 (en) * 2001-05-10 2006-01-24 Battelle Energy Alliance, Llc Rapid classification of biological components
USRE46351E1 (en) 2001-05-10 2017-03-28 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US7695919B2 (en) * 2001-05-10 2010-04-13 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US20030119015A1 (en) * 2001-05-10 2003-06-26 Perlegen Sciences, Inc. Methods for nucleic acid analysis
USRE44031E1 (en) 2001-05-10 2013-02-26 Battelle Energy Alliance, Llc Antibody profiling sensitivity through increased reporter antibody layering
US6552160B2 (en) 2001-05-14 2003-04-22 Arizona Chemical Company Ester-terminated poly(ester-amides) useful for formulating transparent gels in low polarity fluids
US7183116B2 (en) 2001-05-14 2007-02-27 The Institute For Systems Biology Methods for isolation and labeling of sample molecules
AU2002368023A1 (en) * 2001-05-16 2004-03-04 Burstein Technologies, Inc. Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly
US7858385B2 (en) * 2001-05-16 2010-12-28 Los Alamos National Security, Llc Method for detecting binding events using micro-X-ray fluorescence spectrometry
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US20080220441A1 (en) 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US7083920B2 (en) * 2001-05-18 2006-08-01 Nagaoka & Co. Ltd. Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto
TW490783B (en) * 2001-05-22 2002-06-11 Hi Max Optoelectronics Corp Testing device and method built in the wafer scribe line
WO2002095057A2 (en) * 2001-05-24 2002-11-28 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US20020193585A1 (en) * 2001-05-25 2002-12-19 Walke D. Wade Novel human transporter proteins and polynucleotides encoding the same
US20070015144A9 (en) * 2001-05-25 2007-01-18 Genset, S.A. Human cDNAs and proteins and uses thereof
AU2002303827A1 (en) * 2001-05-25 2002-12-09 Invitrogen Corporation Compositions and methods for extension of nucleic acids
JP2005500829A (ja) 2001-05-29 2005-01-13 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト水酸化酵素及び該酵素をコードするポリヌクレオチド
AU2002303933A1 (en) 2001-05-31 2002-12-09 Rochester Institute Of Technology Fluidic valves, agitators, and pumps and methods thereof
US7294478B1 (en) 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
US20030059807A1 (en) * 2001-06-07 2003-03-27 Proligo Llc Microcalorimetric detection of analytes and binding events
US20070184436A1 (en) * 2001-06-07 2007-08-09 Joel Myerson Generic capture probe arrays
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20040048241A1 (en) * 2001-06-11 2004-03-11 Freeman Beverly Annette Methods for attaching molecules
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
EP1406645A4 (en) * 2001-06-14 2005-02-16 Lexicon Genetics Inc NOVEL HUMAN TRANSPORTER PROTEINS AND POLYNUCLEOTIDES ENCODING THESE PROTEINS
US20030096264A1 (en) * 2001-06-18 2003-05-22 Psychiatric Genomics, Inc. Multi-parameter high throughput screening assays (MPHTS)
AU2002316251A1 (en) * 2001-06-18 2003-01-02 Rosetta Inpharmatics, Inc. Diagnosis and prognosis of breast cancer patients
US20030104426A1 (en) * 2001-06-18 2003-06-05 Linsley Peter S. Signature genes in chronic myelogenous leukemia
US7171311B2 (en) * 2001-06-18 2007-01-30 Rosetta Inpharmatics Llc Methods of assigning treatment to breast cancer patients
US20020198666A1 (en) * 2001-06-20 2002-12-26 Kabushikigaisha Dynacom System and method for computer-designing optimum oligo-nucleic acid sequences from nucleic acid base sequences, and oligo-nucleic acid array mounted with the designed oligo-nucleic acid sequences
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US6709989B2 (en) 2001-06-21 2004-03-23 Motorola, Inc. Method for fabricating a semiconductor structure including a metal oxide interface with silicon
DE60221987T2 (de) 2001-06-22 2008-05-15 Stemcells, Inc., Palo Alto Le-zellen (liver engrafting cells), assays und verwendungen davon
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
US7402286B2 (en) * 2001-06-27 2008-07-22 The Regents Of The University Of California Capillary pins for high-efficiency microarray printing device
US6855538B2 (en) * 2001-06-27 2005-02-15 The Regents Of The University Of California High-efficiency microarray printing device
WO2003002765A2 (en) 2001-06-27 2003-01-09 Cancer Research Technology Limited Methods for the diagnosis of cancer based on the obcam and ntm genes
CA2452690C (en) * 2001-06-29 2016-08-16 Veri-Q, Inc. Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US9777312B2 (en) * 2001-06-30 2017-10-03 Enzo Life Sciences, Inc. Dual polarity analysis of nucleic acids
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
CA2450814A1 (en) * 2001-07-02 2003-07-17 The Board Of Trustees Of The Leland Stanford Junior University Microarrays for cell phenotyping and manipulation
US6691042B2 (en) 2001-07-02 2004-02-10 Rosetta Inpharmatics Llc Methods for generating differential profiles by combining data obtained in separate measurements
WO2003004609A2 (en) * 2001-07-03 2003-01-16 Lexicon Genetics Incorporated Novel human kielin-like proteins and polynucleotides encoding the same
US20030096268A1 (en) * 2001-07-06 2003-05-22 Michael Weiner Method for isolation of independent, parallel chemical micro-reactions using a porous filter
US7221632B2 (en) * 2001-07-12 2007-05-22 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
AU2005241112B2 (en) * 2001-07-13 2009-07-30 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
US7297553B2 (en) * 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US7687437B2 (en) 2001-07-13 2010-03-30 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US20030068691A1 (en) * 2001-07-16 2003-04-10 Applera Corporation Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
DE60230927D1 (de) * 2001-07-16 2009-03-05 Caprotec Bioanalytics Gmbh Fangverbindungen, ihre entnahme und verfahren zur analysierung des proteoms und von komplexen zusammensetzungen
WO2003008941A2 (en) * 2001-07-17 2003-01-30 Bioforce Nanosciences, Inc. Combined molecular blinding detection through force microscopy and mass spectrometry
US6646293B2 (en) 2001-07-18 2003-11-11 Motorola, Inc. Structure for fabricating high electron mobility transistors utilizing the formation of complaint substrates
US20030143612A1 (en) * 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
AU2002326441A1 (en) * 2001-07-20 2003-03-03 Burstein Technologies, Inc. Optical analysis disc and related drive assembly for performing interactive centrifugation
US6693298B2 (en) 2001-07-20 2004-02-17 Motorola, Inc. Structure and method for fabricating epitaxial semiconductor on insulator (SOI) structures and devices utilizing the formation of a compliant substrate for materials used to form same
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
US7358066B2 (en) * 2001-07-24 2008-04-15 Serono Genetics Institute S.A. Variants and exons of the GlyT1 transporter
US6667196B2 (en) 2001-07-25 2003-12-23 Motorola, Inc. Method for real-time monitoring and controlling perovskite oxide film growth and semiconductor structure formed using the method
US7348140B1 (en) 2001-07-25 2008-03-25 Acadia Pharmaceuticals, Inc. Clinical indications for genotyping polymorphic variants of G-protein coupled receptors
JP4265149B2 (ja) * 2001-07-25 2009-05-20 セイコーエプソン株式会社 電気光学装置、電気光学装置の製造方法
US20030022394A1 (en) * 2001-07-27 2003-01-30 Dumas David P. Biochips and methods of making same
AU2002367825A1 (en) * 2001-07-30 2003-10-13 Sts Biopolymers, Inc. Graft polymer matrices
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
US20030027258A1 (en) * 2001-08-02 2003-02-06 Chang Fang-Tseh Frank Methods and compositions for pearl oyster cultivation
US6589856B2 (en) 2001-08-06 2003-07-08 Motorola, Inc. Method and apparatus for controlling anti-phase domains in semiconductor structures and devices
US6639249B2 (en) 2001-08-06 2003-10-28 Motorola, Inc. Structure and method for fabrication for a solid-state lighting device
US20030082596A1 (en) * 2001-08-08 2003-05-01 Michael Mittmann Methods of genetic analysis of probes: test3
JP2005511012A (ja) 2001-08-10 2005-04-28 セローノ ジェネティクス インスティテュート ソシエテ アノニム ヒトcDNAおよびタンパク質およびその使用
JP2005500060A (ja) * 2001-08-14 2005-01-06 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトコラーゲンタンパクおよびそれをコードするポリヌクレオチド
KR100455284B1 (ko) * 2001-08-14 2004-11-12 삼성전자주식회사 탄소나노튜브를 이용한 고용량의 바이오분자 검출센서
US6673667B2 (en) 2001-08-15 2004-01-06 Motorola, Inc. Method for manufacturing a substantially integral monolithic apparatus including a plurality of semiconductor materials
WO2003016574A1 (en) * 2001-08-16 2003-02-27 Zhifeng Shao Analysis of gene expression profiles using sequential hybridization
US20080026367A9 (en) * 2001-08-17 2008-01-31 Perlegen Sciences, Inc. Methods for genomic analysis
WO2003018749A2 (en) * 2001-08-22 2003-03-06 Shengfeng Li Compositions and methods for generating antigen-binding units
EP1421217A2 (de) * 2001-08-27 2004-05-26 Zeptosens AG Oberfläche zur immobilisierung von nukleinsäuren
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
US20050032060A1 (en) * 2001-08-31 2005-02-10 Shishir Shah Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
DE10142643A1 (de) * 2001-08-31 2003-04-24 Clondiag Chip Tech Gmbh Detektion von Wechselwirkungen auf Sonden-Arrays
US20030044798A1 (en) * 2001-08-31 2003-03-06 Lefkowitz Steven M. Methods for generating ligand arrays via deposition of ligands onto olefin displaying substrates, and arrays produced thereby
US20050147984A1 (en) * 2001-08-31 2005-07-07 Clondiag Chip Technologies Gmbh Interaction detection on several probe arrays
US20030108972A1 (en) * 2001-12-06 2003-06-12 Zweig Stephen Eliot Tethered receptor-ligand reagent and assay
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
US20030106492A1 (en) * 2001-09-07 2003-06-12 Douglas Levinson Apparatus and method for high-throughput preparation, visualization and screening of compositions
JP2005502872A (ja) * 2001-09-07 2005-01-27 バースタイン テクノロジーズ,インコーポレイティド 光バイオディスクシステムを使用した、核の形態に基づく白血球の型の識別および定量
US20030096324A1 (en) * 2001-09-12 2003-05-22 Mikhail Matveev Methods for differential cell counts including related apparatus and software for performing same
US6974671B1 (en) 2001-09-12 2005-12-13 Salk Institute For Biological Studies Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
WO2003024923A1 (en) * 2001-09-14 2003-03-27 Axys Pharmaceuticals, Inc. Sulfonamide compounds as protease inhibitors
US20060188875A1 (en) * 2001-09-18 2006-08-24 Perlegen Sciences, Inc. Human genomic polymorphisms
US20070098728A1 (en) * 2001-09-24 2007-05-03 Pedersen Finn S Novel compositions and methods in cancer
US7202028B2 (en) * 2001-09-24 2007-04-10 The University Of North Carolina At Chapel Hill Methods for the electrochemical detection of multiple target compounds
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
JP4754746B2 (ja) * 2001-09-28 2011-08-24 オリンパス株式会社 棒状担体およびこれを具備するシリンダー反応容器
US20030068621A1 (en) * 2001-10-04 2003-04-10 Jonathan Briggs Method and device for producing oligonucleotide arrays
US20040053232A1 (en) * 2001-10-05 2004-03-18 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
DE10149684B4 (de) * 2001-10-09 2005-02-17 Clondiag Chip Technologies Gmbh Vorrichtung zur Halterung eines Substanzbibliothekenträgers
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
CA2463725A1 (en) 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
AU2002334769A1 (en) * 2001-10-12 2003-04-28 Duke University Image analysis of high-density synthetic dna microarrays
AU2002334772A1 (en) * 2001-10-12 2003-04-28 Duke University Methods for image analysis of high-density synthetic dna microarrays
CA2741049C (en) 2001-10-15 2019-02-05 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
WO2003033718A1 (en) * 2001-10-17 2003-04-24 Global Genomics Ab Synthesis of oligonucleotides on solid support and assembly into doublestranded polynucleotides
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
US20040166490A1 (en) * 2002-12-17 2004-08-26 Morris David W. Novel therapeutic targets in cancer
US20040126762A1 (en) * 2002-12-17 2004-07-01 Morris David W. Novel compositions and methods in cancer
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
ITMI20010566U1 (it) * 2001-10-25 2003-04-25 Troletti Adriano Apparecchio asciugacapelli, ad elevata praticita' di impiego
DK1440083T3 (da) 2001-10-25 2013-03-25 Medical Res Council Molekyler
US7211923B2 (en) 2001-10-26 2007-05-01 Nth Tech Corporation Rotational motion based, electrostatic power source and methods thereof
WO2003098661A2 (en) * 2001-10-26 2003-11-27 Integrated Nano-Technologies, Llc Chemical and biological hazard sensor system and methods thereof
WO2003036225A1 (en) * 2001-10-26 2003-05-01 University Of Rochester Method for biomolecular sensing and system thereof
US7378775B2 (en) 2001-10-26 2008-05-27 Nth Tech Corporation Motion based, electrostatic power source and methods thereof
US20030082560A1 (en) * 2001-10-29 2003-05-01 Yingjian Wang Method of making interactive protein arrays
WO2003053855A2 (en) * 2001-10-30 2003-07-03 University Of Delaware Rapid high-throughput screen for detecting biological species in ballast water
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20050124022A1 (en) * 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
WO2003038130A2 (en) * 2001-10-31 2003-05-08 Pfizer Products Inc. Therapeutics and diagnostics for disorders of erythropoiesis
US7175983B2 (en) * 2001-11-02 2007-02-13 Abmaxis, Inc. Adapter-directed display systems
US20040002121A1 (en) * 2001-11-06 2004-01-01 Regan Jeffrey F. High throughput methods and devices for assaying analytes in a fluid sample
AU2002364894A1 (en) * 2001-11-09 2003-06-30 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on alpha-2-macroglobulin
AU2002360361A1 (en) * 2001-11-09 2003-06-10 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
US20080094974A1 (en) * 2001-11-09 2008-04-24 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
AU2002359446B2 (en) 2001-11-09 2008-12-04 Georgetown University Novel isoforms of vascular endothelial cell growth inhibitor
US20030124599A1 (en) * 2001-11-14 2003-07-03 Shiping Chen Biochemical analysis system with combinatorial chemistry applications
DE10156467A1 (de) * 2001-11-16 2003-06-05 Micronas Gmbh Träger zur Synthese sowie Verfahren zur Herstellung von Biopolymeren
JP2005509882A (ja) * 2001-11-20 2005-04-14 バースタイン テクノロジーズ,インコーポレイティド 細胞分析のための光バイオディスクおよび流体回路ならびにそれに関連する方法
US20040023237A1 (en) * 2001-11-26 2004-02-05 Perelegen Sciences Inc. Methods for genomic analysis
AU2002351164A1 (en) * 2001-11-26 2003-06-10 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
US20040180344A1 (en) * 2003-03-14 2004-09-16 Morris David W. Novel therapeutic targets in cancer
US20060040262A1 (en) * 2002-12-27 2006-02-23 Morris David W Novel compositions and methods in cancer
US20040197778A1 (en) * 2002-12-26 2004-10-07 Sagres Discovery, Inc. Novel compositions and methods in cancer
ES2403560T3 (es) 2001-11-30 2013-05-20 Fluidigm Corporation Dispositivo microfluídico y procedimientos de utilización del mismo
CA2469049A1 (en) * 2001-12-07 2003-06-19 Chiron Corporation Endogenous retrovirus polypeptides linked to oncogenic transformation
AU2002358110A1 (en) * 2001-12-10 2003-07-09 Novartis Ag Methods of treating psychosis and schizophrenia based on a polymorphism in the ctf gene
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US7102752B2 (en) 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US7098041B2 (en) 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
ATE451387T1 (de) * 2001-12-18 2009-12-15 Endocube Sas Neue mit dem zelltod assoziierte proteine aus der thap familie und par4 verwandte signalwege, die bei der kontrolle von apoptosis involviert sind
EP1321768A1 (en) * 2001-12-18 2003-06-25 Roche Diagnostics GmbH Diagnosis of endometriosis from menstrual blood
US7858297B2 (en) * 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
DE60228995D1 (de) * 2001-12-19 2008-10-30 Affymetrix Inc Arrayplatten und verfahren zur herstellung von arrayplatten
AU2002364077A1 (en) * 2001-12-21 2003-07-30 Gene Logic, Inc. Gene expression profiles in stomach cancer
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
CN1610742B (zh) * 2001-12-26 2010-05-05 佳能株式会社 探针介质
US7335153B2 (en) 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
AU2002361908A1 (en) * 2001-12-31 2003-07-24 Quark Biotech, Inc. Methods for identifying marker genes for cancer
US6897025B2 (en) * 2002-01-07 2005-05-24 Perlegen Sciences, Inc. Genetic analysis systems and methods
US20030188343A1 (en) * 2002-01-09 2003-10-02 Lynx Therapeutics, Inc. Identification of genes associated with growth in plants
FR2834521B1 (fr) * 2002-01-10 2004-12-17 Bio Merieux Procede de detection et/ou d'identification de l'espece animale d'origine de la matiere animale contenue dans un echantillon
AU2003202951A1 (en) * 2002-01-14 2003-07-30 Burstein Technologies, Inc. Method and apparatus for visualizing data
DE10201463B4 (de) 2002-01-16 2005-07-21 Clondiag Chip Technologies Gmbh Reaktionsgefäß zur Durchführung von Array-Verfahren
US8008012B2 (en) 2002-01-24 2011-08-30 Health Discovery Corporation Biomarkers downregulated in prostate cancer
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
CA2471018A1 (en) * 2002-01-28 2003-08-07 Burstein Technologies, Inc. Methods and apparatus for logical triggering of an optical bio-disc
US20050002827A1 (en) * 2002-01-29 2005-01-06 Mcintyre Kevin Robert Optical discs including equi-radial and/or spiral analysis zones and related disc drive systems and methods
US20050019901A1 (en) * 2002-01-31 2005-01-27 Evgenia Matveeva Methods for synthesis of bio-active nanoparticles and nanocapsules for use in optical bio-disc assays and disc assembly including same
US7418351B2 (en) * 2002-01-31 2008-08-26 Rosetta Inpharmatics Llc Methods for analysis of measurement errors in measured signals
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US20030149933A1 (en) * 2002-02-01 2003-08-07 Marco Falcioni Graphical design of chemical discovery processes
WO2003065282A1 (en) * 2002-02-01 2003-08-07 Rosetta Inpharmatics Llc Computer systems and methods for identifying genes and determining pathways associated with traits
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
US6861523B2 (en) 2002-02-08 2005-03-01 Torrey Pines Institute For Molecular Studies 1,3,5- trisubstituted-1,3,5-triazine-2,4,6-trione compounds and libraries
US7553619B2 (en) * 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
AU2003217379A1 (en) * 2002-02-15 2003-09-09 Somalogic, Inc. Methods and reagents for detecting target binding by nucleic acid ligands
US20030156136A1 (en) * 2002-02-15 2003-08-21 Cattell Herbert F. Method and system for visualization of results of feature extraction from molecular array data
US20030162178A1 (en) * 2002-02-25 2003-08-28 O'hagan David Variable microarray and methods of detecting one or more anlaytes in a sample
NL1020066C2 (nl) * 2002-02-26 2003-08-27 Dutch Space B V Inrichting voor het vervaardigen van een DNA-testarray.
US20030161761A1 (en) * 2002-02-28 2003-08-28 Williams Roger O. Apparatus and method for composing high density materials onto target substrates by a rapid sequence
US6929951B2 (en) * 2002-02-28 2005-08-16 Agilent Technologies, Inc. Method and system for molecular array scanner calibration
US6914229B2 (en) * 2002-02-28 2005-07-05 Agilent Technologies, Inc. Signal offset for prevention of data clipping in a molecular array scanner
US6770892B2 (en) 2002-02-28 2004-08-03 Agilent Technologies, Inc. Method and system for automated focus-distance determination for molecular array scanners
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US20030203384A1 (en) * 2002-03-08 2003-10-30 Chafin David R. Multiplex detection of biological materials in a sample
AU2003213819C1 (en) 2002-03-11 2010-03-04 Molecular Insight Pharmaceuticals, Inc. Technetium-dipyridine complexes, and methods of use thereof
AU2003224674A1 (en) * 2002-03-11 2003-09-29 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
EP1485408A2 (en) 2002-03-13 2004-12-15 Bayer CropScience S.A. Mutagenesis of aspergillus fungi and genes essential for growth
SE0200817D0 (sv) * 2002-03-15 2002-03-15 Ulf Gyllensten Method and kit for detection of mutations in mitochondrial DNA
US7689022B2 (en) 2002-03-15 2010-03-30 Affymetrix, Inc. System, method, and product for scanning of biological materials
US20030177380A1 (en) * 2002-03-18 2003-09-18 Woods Stanley P. Devices for storing array data and methods of using the same
AU2003220487A1 (en) * 2002-03-19 2003-10-08 Cengent Therapeutics, Inc. Discrete bayesian analysis of data
WO2003080649A2 (en) * 2002-03-20 2003-10-02 Regents Of The University Of Minnesota Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
US20040023267A1 (en) * 2002-03-21 2004-02-05 Morris David W. Novel compositions and methods in cancer
US20040006431A1 (en) * 2002-03-21 2004-01-08 Affymetrix, Inc., A Corporation Organized Under The Laws Of Delaware System, method and computer software product for grid placement, alignment and analysis of images of biological probe arrays
US7193069B2 (en) * 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
AR039102A1 (es) * 2002-03-26 2005-02-09 Lai Derhsing Chip de circuitos integrados para ensayos biologicos
EP2270197A3 (en) 2002-03-26 2011-02-16 Massachusetts Institute of Technology Targets, methods, and reagents for diagnosis and treatment of schizophrenia
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
US20030186279A1 (en) * 2002-03-28 2003-10-02 Affymetrix, Inc. Large scale genotyping methods
US20030186302A1 (en) * 2002-03-29 2003-10-02 Yixin Wang Colorectal cancer diagnostics
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
AU2003230806B2 (en) 2002-04-04 2009-05-07 Zoetis Belgium S.A. Immunostimulatory G,U-containing oligoribonucleotides
US6773888B2 (en) * 2002-04-08 2004-08-10 Affymetrix, Inc. Photoactivatable silane compounds and methods for their synthesis and use
US20040019432A1 (en) * 2002-04-10 2004-01-29 Sawafta Reyad I. System and method for integrated computer-aided molecular discovery
US20030195431A1 (en) * 2002-04-10 2003-10-16 Sukhatme Vikas P. Observation of effects of body fluids on indicator cells for disease diagnosis
US20030194709A1 (en) * 2002-04-10 2003-10-16 Xing Yang Hydrophobic zone device
US7687256B2 (en) 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
WO2003087774A2 (en) 2002-04-12 2003-10-23 Curators Of The University Of Missouri Ecist microarrays for dual screening of dna hypermethylation and gene silencing
AU2003232477A1 (en) * 2002-04-16 2003-10-27 Dot Diagnostics B.V. Human papilloma virus detection with dna microarray
DK1355152T3 (da) 2002-04-17 2010-06-14 Deutsches Krebsforsch Fremgangsmåde til at identificere en forbindelse til modulering af wnt-signalkaskaden
EA010903B1 (ru) 2002-04-19 2008-12-30 Дайверса Корпорейшн Фосфолипазы, нуклеиновые кислоты, кодирующие их, и способы их получения и применения
DE10217569A1 (de) * 2002-04-19 2003-11-13 Infineon Technologies Ag Vorrichtung auf Basis von partiell oxidiertem porösen Silizium
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
CA2483433A1 (en) * 2002-04-23 2003-11-06 Applera Corporation Isolated human proteins that show high homology to human disease proteins, nucleic acid molecules encoding these human proteins, and uses thereof
US20040023275A1 (en) * 2002-04-29 2004-02-05 Perlegen Sciences, Inc. Methods for genomic analysis
US6946285B2 (en) * 2002-04-29 2005-09-20 Agilent Technologies, Inc. Arrays with elongated features
CN1202266C (zh) * 2002-04-30 2005-05-18 欧姆龙株式会社 设置有光扫描装置的生物芯片和该生物芯片的读取方法
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223534B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7223368B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
DE60323625D1 (de) * 2002-05-03 2008-10-30 Vialogy Llc Verfahren zur charakterisierung der ausgangssignale eines microarrays
US20060052320A1 (en) * 2002-05-06 2006-03-09 Limin Li Mammalian genes involved in rapamycin resistance and tumorgenesis annexin XIII genes
US20030216870A1 (en) * 2002-05-07 2003-11-20 Wolber Paul K. Method and system for normalization of micro array data based on local normalization of rank-ordered, globally normalized data
ATE534035T1 (de) 2002-05-08 2011-12-15 Northwest Biotherapeutics Inc Qualitätstests für antigenpräsentierende zellen
US7217512B2 (en) * 2002-05-09 2007-05-15 Corning Incorporated Reagent and method for attaching target molecules to a surface
RU2004136990A (ru) * 2002-05-17 2005-08-10 Байлор Колледж Оф Медсин (Us) Дифференциальные картины экспрессии генов, которые предсказывают хемочувствительность и хеморезистентность к доцетакселу
EP1573056A4 (en) * 2002-05-17 2007-11-28 Nugen Technologies Inc METHODS FOR FRAGMENTATION, LABELING AND IMMOBILIZATION OF NUCLEIC ACIDS
AU2003233585A1 (en) * 2002-05-20 2003-12-12 Rosetta Inpharmatics Llc Computer systems and methods for subdividing a complex disease into component diseases
US7221785B2 (en) * 2002-05-21 2007-05-22 Agilent Technologies, Inc. Method and system for measuring a molecular array background signal from a continuous background region of specified size
US20030220746A1 (en) * 2002-05-21 2003-11-27 Srinka Ghosh Method and system for computing and applying a global, multi-channel background correction to a feature-based data set obtained from scanning a molecular array
TWI221523B (en) * 2002-05-21 2004-10-01 Sony Corp Bioassay method, bioassay device, and bioassay substrate
US20050033525A1 (en) * 2002-05-21 2005-02-10 Corson John F. Method and system for computing and applying a user-defined, global, multi-channel background correction to a feature-based data set obtained from reading a microarray
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
US20030219755A1 (en) * 2002-05-24 2003-11-27 Nanibhushan Dattagupta Compositions and methods for performing hybridization assays using target enhanced signal amplification (TESA)
US6763308B2 (en) 2002-05-28 2004-07-13 Sas Institute Inc. Statistical outlier detection for gene expression microarray data
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US7537936B2 (en) * 2002-05-31 2009-05-26 Agilent Technologies, Inc. Method of testing multiple fluid samples with multiple biopolymer arrays
US6806460B2 (en) * 2002-05-31 2004-10-19 Agilent Technologies, Inc. Fluorescence detection with increased dynamic range
JP4193421B2 (ja) * 2002-06-06 2008-12-10 ソニー株式会社 バイオアッセイ装置及びその製造方法、並びにバイオアッセイ方法
US8518694B2 (en) * 2002-06-13 2013-08-27 Novartis Vaccines And Diagnostics, Inc. Nucleic acid vector comprising a promoter and a sequence encoding a polypeptide from the endogenous retrovirus PCAV
US20050239195A1 (en) * 2002-06-13 2005-10-27 Millenium Biologix Ag Reaction chamber
US7108976B2 (en) * 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US20030231986A1 (en) * 2002-06-18 2003-12-18 Eastman Kodak Company Micro-array identification means
US7332273B2 (en) 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US7144950B2 (en) 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
EP1534857B1 (en) 2002-06-20 2010-08-04 The Regents of The University of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US7091049B2 (en) 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
WO2004003551A1 (ja) * 2002-06-28 2004-01-08 Canon Kabushiki Kaisha プローブ担体、プローブ担体の作成方法及びプローブ担体の評価方法及びそれを用いた標的核酸の検出方法
US20040137491A1 (en) * 2002-06-28 2004-07-15 Tadashi Okamoto Method of analyzing probe carrier using time-of-flight secondary ion mass spectrometry
JP2004024203A (ja) * 2002-06-28 2004-01-29 Canon Inc 飛行時間型二次イオン質量分析法によるrnaの分析方法
JP3658397B2 (ja) * 2002-06-28 2005-06-08 キヤノン株式会社 飛行時間型二次イオン質量分析法による素子の情報取得方法、および、情報取得装置
US7569343B2 (en) * 2002-06-28 2009-08-04 Rosetta Inpharmatics Llc Methods to assess quality of microarrays
US20040005769A1 (en) * 2002-07-03 2004-01-08 Cabot Microelectronics Corp. Method and apparatus for endpoint detection
DE10230320A1 (de) * 2002-07-05 2004-02-05 Marcel Rogalla Programmierbare Beleuchtungsvorrichtung zur hochauflösenden, massiv parallelen, räumlichen Systhese und Analyse von Microarrays
US20040009574A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae capsular polysaccharide synthesis genes
USH2223H1 (en) 2002-07-11 2008-09-02 The United States Of America As Represented By The Secretary Of The Navy Patterned, micrometer-sized antibody features
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
US20050185175A1 (en) * 2002-07-16 2005-08-25 Canos Avelino C. Rotary support and apparatus used for the multiple spectroscopic characterisation of samples of solid materials
EP1552010B1 (en) * 2002-07-19 2010-06-09 Althea Technologies, Inc. Strategies for gene expression analysis
WO2004014941A1 (de) * 2002-07-23 2004-02-19 Universität Leipzig Verfahren zur selektiven markierung von peptiden
US20040110235A1 (en) * 2002-07-25 2004-06-10 David Epstein Regulated aptamer therapeutics
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US20040018497A1 (en) * 2002-07-26 2004-01-29 Warden Craig H Human obesity LIPIN3 polynucleotide and polypeptide sequences and methods of use thereof
WO2004011144A2 (en) * 2002-07-29 2004-02-05 Dumas David P Transparent polymer support for electrophoresis and electrochromatography and related methods
US7632916B2 (en) * 2002-08-02 2009-12-15 3M Innovative Properties Company Process to modify polymeric materials and resulting compositions
AU2003254216A1 (en) * 2002-08-02 2004-02-23 Applera Corporation Fluorescence polarization assay
WO2004013727A2 (en) * 2002-08-02 2004-02-12 Rosetta Inpharmatics Llc Computer systems and methods that use clinical and expression quantitative trait loci to associate genes with traits
AU2003257109A1 (en) * 2002-08-05 2004-02-23 Invitrogen Corporation Compositions and methods for molecular biology
US20060073475A1 (en) * 2002-08-09 2006-04-06 Nanibhushan Dattagupta Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins
AU2003265525A1 (en) * 2002-08-15 2004-03-19 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr7 genes
WO2004020582A2 (en) * 2002-08-15 2004-03-11 Functional Genetics, Inc. Mammalian genes involved in rapamycin resistance and tumorgenesis: rapr6 genes
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
US7118865B2 (en) * 2002-08-16 2006-10-10 Regents Of The University Of Minnesota Methods for diagnosing severe systemic lupus erythematosus
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7473535B2 (en) * 2002-08-20 2009-01-06 The Institute For Systems Biology Chemical reagents and methods for detection and quantification of proteins in complex mixtures
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7267751B2 (en) * 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
US20040038214A1 (en) * 2002-08-23 2004-02-26 Corson John F. Method and system for reading a molecular array
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
EA007653B1 (ru) 2002-08-26 2006-12-29 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Способы и композиции обнаружения и анализа полинуклеотидов с помощью светособирающих полихромофоров
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7432105B2 (en) 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
AU2003258683A1 (en) * 2002-09-03 2004-03-29 Zeptosens Ag Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners
WO2004023143A2 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren
MXPA05002444A (es) 2002-09-06 2005-09-30 Insert Therapeutics Inc Polimeros a base de ciclodextrina para el suministro de agentes terapeuticos.
CA2495895A1 (en) * 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
AU2003260292A1 (en) * 2002-09-11 2004-04-30 Exiqon A/S A population of nucleic acids including a subpopulation of lna oligomers
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US6889143B2 (en) * 2002-09-12 2005-05-03 Intergrated Dna Technologies, Inc. Methods and systems for estimating the melting temperature (TM) for polynucleotide molecules
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
WO2005003326A2 (en) * 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
US20050037428A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks, the building blocks, and methods
US20050170385A1 (en) * 2002-09-16 2005-08-04 Receptors Llc Artificial receptors including gradients
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
DK1542714T3 (da) 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
EP2213615A3 (en) 2002-09-25 2012-02-29 California Institute of Technology Microfluidic Large Scale Integration
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
DE10245432A1 (de) 2002-09-27 2004-04-08 Micronas Gmbh Verfahren und Vorrichtung zum Detektieren mindestens eines Lumineszenz-Stoffs
WO2004029586A1 (en) * 2002-09-27 2004-04-08 Nimblegen Systems, Inc. Microarray with hydrophobic barriers
US7135288B2 (en) 2002-09-27 2006-11-14 Ut-Battelle, Llc Combinatorial synthesis of ceramic materials
US20040110212A1 (en) * 2002-09-30 2004-06-10 Mccormick Mark Microarrays with visual alignment marks
DE10393406T5 (de) 2002-09-30 2005-12-22 Nimblegen Systems, Inc., Madison Parallele Beladung von Arrays
JP2006500954A (ja) * 2002-10-01 2006-01-12 ニンブルゲン システムズ インコーポレイテッド 単一のアレイ特徴部に複数のオリゴヌクレオチドを有するマイクロアレイ
WO2004040001A2 (en) 2002-10-02 2004-05-13 California Institute Of Technology Microfluidic nucleic acid analysis
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US20040067492A1 (en) * 2002-10-04 2004-04-08 Allan Peng Reverse transcription on microarrays
US7459273B2 (en) * 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US20050003369A1 (en) * 2002-10-10 2005-01-06 Affymetrix, Inc. Method for depleting specific nucleic acids from a mixture
US20040120861A1 (en) * 2002-10-11 2004-06-24 Affymetrix, Inc. System and method for high-throughput processing of biological probe arrays
KR100508108B1 (ko) * 2002-10-14 2005-08-18 학교법인 포항공과대학교 중합체 패턴의 형성 방법
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
EP1552025A4 (en) * 2002-10-18 2006-12-13 Cylene Pharmaceuticals Inc METHODS FOR IDENTIFYING TARGETED ANTIVIRAL MOLECULES TO QUADRUPLEX STRUCTURES
US7718787B2 (en) 2002-10-18 2010-05-18 Lg Life Sciences Limited Gene families associated with cancers
US20040219565A1 (en) * 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
US20040076961A1 (en) * 2002-10-21 2004-04-22 Lewis Mark A. Biomolecule retaining material and methods for attaching biomolecules to a surface
CA2429101A1 (en) * 2002-10-24 2004-04-24 Ben Gao Method and equipment to monitor nucleic acid hybridization on a dna chip using four-dimensional parameters
US20040115722A1 (en) * 2002-10-25 2004-06-17 Mel Kronick Biopolymeric arrays and methods of producing the same
US7635564B2 (en) * 2002-10-25 2009-12-22 Agilent Technologies, Inc. Biopolymeric arrays having replicate elements
US6742843B2 (en) * 2002-10-25 2004-06-01 Knoll, Inc. Cable control with overload protection device
WO2004039953A2 (en) * 2002-10-28 2004-05-13 Xeotron Corporation Array oligomer synthesis and use.
JP3447009B1 (ja) * 2002-10-29 2003-09-16 實 平垣 構築物用構成体およびその製造方法
US7195908B2 (en) 2002-10-31 2007-03-27 Corning Incorporated Supports treated with triamine for immobilizing biomolecules
US20050037369A1 (en) * 2002-10-31 2005-02-17 Neote Kuldeep Singh Panels of molecular targets differentially expressed during CD8+ T cell priming, and methods for therapy and diagnosis utilizing the same
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Jx日鉱日石エネルギー株式会社 潤滑油組成物
US20040086892A1 (en) * 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
GB0226593D0 (en) * 2002-11-14 2002-12-24 Consultants Ltd Compounds
AU2002952696A0 (en) 2002-11-14 2002-11-28 Genomics Research Partners Pty Ltd Status determination
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US20060166206A1 (en) * 2002-11-15 2006-07-27 Sangamo Biosciences, Inc. Methods and compositions for analysis of regulatory sequences
WO2004046691A2 (en) * 2002-11-18 2004-06-03 Genospectra, Inc. Uncaging devices
EP1420248A3 (de) * 2002-11-18 2004-05-26 Schott Glas Validiertes Design für Mikroarrays
US7250289B2 (en) * 2002-11-20 2007-07-31 Affymetrix, Inc. Methods of genetic analysis of mouse
US7314750B2 (en) * 2002-11-20 2008-01-01 Affymetrix, Inc. Addressable oligonucleotide array of the rat genome
EP1897959A1 (en) * 2002-11-22 2008-03-12 The Johns Hopkins University Target for therapy of cognitive impairment
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US20040101861A1 (en) * 2002-11-27 2004-05-27 Little Roger G. Resonant cavity photodiode array for rapid DNA microarray readout
TWI255971B (en) * 2002-11-29 2006-06-01 Asml Netherlands Bv Lithographic apparatus and device manufacturing method
EP1424599B1 (en) * 2002-11-29 2008-03-12 ASML Netherlands B.V. Lithographic apparatus and device manufacturing method
US20040109045A1 (en) * 2002-12-06 2004-06-10 Eastman Kodak Company Print head for micro-deposition of bio-molecules
EP2583958B1 (en) 2002-12-09 2016-08-10 Massachusetts Institute of Technology (MIT) Ligands for metals and improved metal-catalyzed processes based thereon
US20040259111A1 (en) * 2002-12-10 2004-12-23 Rosetta Inpharmatics Llc Automated system and method for preparing an assay ready biological sample
US20040115654A1 (en) * 2002-12-16 2004-06-17 Intel Corporation Laser exposure of photosensitive masks for DNA microarray fabrication
US20070042978A1 (en) * 2002-12-19 2007-02-22 Jean-Philippe Girard Nf-hev compositions and methods of use
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US7682565B2 (en) * 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
WO2004076683A2 (en) * 2003-02-26 2004-09-10 Callida Genomics, Inc. Random array dna analysis by hybridization
US20040120859A1 (en) * 2002-12-20 2004-06-24 Kocher Thomas E. Biomolecular micro-deposition system
US7642085B2 (en) * 2002-12-22 2010-01-05 The Scripps Research Institute Protein arrays
US20040180368A1 (en) * 2002-12-23 2004-09-16 Affymetrix, Inc. Method for producing a high density nucleic acid array using activators
US7541152B2 (en) * 2002-12-24 2009-06-02 Agilent Technologies, Inc. Integrated light source for diagnostic arrays
US20040126766A1 (en) * 2002-12-26 2004-07-01 Amorese Douglas A. Breakaway seal for processing a subarray of an array
AU2003303502A1 (en) 2002-12-27 2004-07-29 Rosetta Inpharmatics Llc Computer systems and methods for associating genes with traits using cross species data
US6977153B2 (en) * 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
JP2006512583A (ja) * 2003-01-02 2006-04-13 バイオフォース ナノサイエンシズ インコーポレイテッド 小サンプル体積における分子分析の方法及び装置
EP1587840B1 (en) * 2003-01-13 2008-08-20 The Regents Of The University Of Michigan Method to form a protein microarray system
JP4741458B2 (ja) * 2003-01-16 2011-08-03 カプロテック・バイオアナリティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 捕獲化合物、その収集物ならびにプロテオームおよび複合組成物を分析するための方法
KR100994566B1 (ko) * 2003-01-20 2010-11-15 삼성전자주식회사 고정화 영역을 갖는 포토레지스트 막을 포함하는 어레이장치 및 이를 이용한 표적 물질 검출방법
US8081792B2 (en) 2003-08-20 2011-12-20 Illumina, Inc. Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same
US7996155B2 (en) 2003-01-22 2011-08-09 Microsoft Corporation ANOVA method for data analysis
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
WO2004067191A2 (en) 2003-01-29 2004-08-12 President And Fellows Of Harward College Alteration of surface affinities
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
US20050048573A1 (en) * 2003-02-03 2005-03-03 Plexxikon, Inc. PDE5A crystal structure and uses
WO2004071436A2 (en) 2003-02-10 2004-08-26 Thomas Jefferson University The use of gcc ligands
US20040157220A1 (en) 2003-02-10 2004-08-12 Purnima Kurnool Methods and apparatus for sample tracking
WO2004077014A2 (en) 2003-02-13 2004-09-10 The Regents Of The University Of California Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores
US7192703B2 (en) 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
US20070218071A1 (en) * 2003-09-15 2007-09-20 Morris David W Novel therapeutic targets in cancer
US20040170982A1 (en) * 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
US7767387B2 (en) * 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
WO2004074321A2 (en) 2003-02-14 2004-09-02 Sagres Discovery, Inc. Therapeutic gpcr targets in cancer
US7759513B2 (en) * 2003-02-21 2010-07-20 Nigu Chemie Gmbh Photolabile protective groups for improved processes to prepare oligonucleotide arrays
US20050014249A1 (en) * 2003-02-21 2005-01-20 Norbert Staimer Chromatographic analysis on optical bio-discs and methods relating thereto
US20040166495A1 (en) * 2003-02-24 2004-08-26 Greinwald John H. Microarray-based diagnosis of pediatric hearing impairment-construction of a deafness gene chip
US20090124514A1 (en) * 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
JP2007524374A (ja) * 2003-02-28 2007-08-30 プレキシコン,インコーポレーテッド Pyk2結晶構造および使用
US20040235019A1 (en) * 2003-03-06 2004-11-25 Agouron Pharmaceuticals, Inc. Diagnostics and therapeutics for the gene expression signature of PPAR-gamma receptor ligand
EP3023498B1 (en) 2003-03-06 2018-11-28 BASF Enzymes LLC Amylases, nucleic acids encoding them and methods for making and using them
CA3007908A1 (en) 2003-03-07 2005-04-14 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
FR2852317B1 (fr) 2003-03-13 2006-08-04 Biopuces a sondes et leurs methodes d'utilisation
JP2004279196A (ja) * 2003-03-14 2004-10-07 Dainippon Printing Co Ltd バイオマイクロアレイ用基板およびバイオマイクロアレイ
US20040235022A1 (en) * 2003-03-19 2004-11-25 Ralf Mauritz Quality control method for manufacturing biopolymer arrays
US20040248287A1 (en) * 2003-03-28 2004-12-09 Qianjin Hu Multi-array systems and methods of use thereof
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20040223874A1 (en) * 2003-03-31 2004-11-11 Canon Kabushiki Kaisha Biochemical reaction cartridge
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040191782A1 (en) * 2003-03-31 2004-09-30 Yixin Wang Colorectal cancer prognostics
EP1473085B1 (en) * 2003-03-31 2015-07-22 Canon Kabushiki Kaisha Biochemical reaction cartridge
DE10315074A1 (de) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
CA2521402C (en) 2003-04-04 2015-01-13 Diversa Corporation Pectate lyases, nucleic acids encoding them and methods for making and using them
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
US7833714B1 (en) 2003-04-11 2010-11-16 Affymetrix, Inc. Combinatorial affinity selection
EP2065395A1 (en) 2003-04-14 2009-06-03 Novartis AG Gene expression associated with osteoblast differentiation
US7402386B2 (en) * 2003-04-14 2008-07-22 Nugen Technologies, Inc. Global amplification using random priming by a composite primer
US20040210036A1 (en) * 2003-04-15 2004-10-21 Nanogen, Inc. Peptide substrate libraries
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
EP2322205A1 (en) 2003-04-18 2011-05-18 Biogen Idec MA Inc. Polymer-conjugated glycosylated neublastin
WO2004096985A2 (en) * 2003-04-24 2004-11-11 Mayo Foundation For Medical Education And Research Methods for assessing biologic diversity
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
MXPA05011404A (es) * 2003-04-25 2006-05-31 Johnson & Johnson Conservacion del arn en una muestra biologica.
US20050064452A1 (en) * 2003-04-25 2005-03-24 Schmid Matthew J. System and method for the detection of analytes
JP5265869B2 (ja) * 2003-05-02 2013-08-14 ザ ユニバーシティー オブ ウェスタン オンタリオ 放射性医薬化合物の合成に有用な補欠分子族
GB0310270D0 (en) * 2003-05-03 2003-06-11 Univ Edinburgh Biomolecular devices
US20050136395A1 (en) * 2003-05-08 2005-06-23 Affymetrix, Inc Methods for genetic analysis of SARS virus
US7709610B2 (en) 2003-05-08 2010-05-04 Facet Biotech Corporation Therapeutic use of anti-CS1 antibodies
US20050025763A1 (en) 2003-05-08 2005-02-03 Protein Design Laboratories, Inc. Therapeutic use of anti-CS1 antibodies
WO2004099440A1 (en) * 2003-05-09 2004-11-18 Capital Biochip Company, Ltd. Methods and compositions for detecting sars virus
US20040265880A1 (en) * 2003-05-09 2004-12-30 Sigma-Aldrich Co. Genomic and proteomic approaches for the development of cell culture medium
EP1627062A1 (en) 2003-05-14 2006-02-22 Domantis Limited A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
CA2525619A1 (en) * 2003-05-16 2005-03-03 Rosetta Inpharmatics, Llc Methods and compositions for rna interference
WO2004104922A2 (en) * 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
SE527896C2 (sv) * 2003-05-20 2006-07-04 Aamic Ab Optisk testanordning för biologiska prover, samt en microarray till anordningen och metoden för dess användning
US20040235199A1 (en) * 2003-05-22 2004-11-25 Jung Hee Tae Method for fabricating a nanoarray using the self-assembly of supramolecules and staining of metals
US20070105105A1 (en) * 2003-05-23 2007-05-10 Mount Sinai School Of Medicine Of New York University Surrogate cell gene expression signatures for evaluating the physical state of a subject
JP2006525814A (ja) * 2003-05-23 2006-11-16 コールド スプリング ハーバー ラボラトリー ヌクレオチド配列の実質的表示
US20040241657A1 (en) * 2003-05-28 2004-12-02 Perlegen Sciences, Inc. Liver related disease compositions and methods
US7729864B2 (en) 2003-05-30 2010-06-01 Merck Sharp & Dohme Corp. Computer systems and methods for identifying surrogate markers
US20040241659A1 (en) * 2003-05-30 2004-12-02 Applera Corporation Apparatus and method for hybridization and SPR detection
FR2855832B1 (fr) * 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
KR100549103B1 (ko) * 2003-06-05 2006-02-06 한국과학기술원 탄소나노튜브 어레이의 제작방법
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
CA2528572C (en) 2003-06-10 2020-08-25 The Trustees Of Boston University Gene expression analysis of airway epithelial cells for diagnosing lung cancer
CA2529016A1 (en) * 2003-06-12 2004-12-23 Accupath Diagnostic Laboratories, Inc. Method and system for the analysis of high density cells samples
US8133670B2 (en) * 2003-06-13 2012-03-13 Cold Spring Harbor Laboratory Method for making populations of defined nucleic acid molecules
WO2005003301A2 (en) * 2003-06-17 2005-01-13 Signal Pharmaceuticals, Inc. Methods, compositions, and kits for predicting the effect of compounds on hot flash symptoms
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
JP4367901B2 (ja) * 2003-06-20 2009-11-18 キヤノン株式会社 スポット・パターン暗号化機能を具えるスポッター、ならびにスポット・パターン暗号化に対応した検出装置
US7642064B2 (en) 2003-06-24 2010-01-05 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
EP1636586B1 (en) * 2003-06-24 2009-07-22 Ventana Medical Systems, Inc. Enzyme-catalyzed metal deposition for the enhanced in situ detection of immunohistochemical epitopes and nucleic acid sequences
WO2005001429A2 (en) * 2003-06-27 2005-01-06 Nagaoka & Co., Ltd. Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
US7534563B2 (en) * 2003-06-30 2009-05-19 Agilent Technologies, Inc. Methods for producing ligand arrays
AU2004255223A1 (en) * 2003-06-30 2005-01-20 Massachusetts Institute Of Technology EGR genes as targets for the diagnosis and treatment of schizophrenia
BRPI0412279A (pt) 2003-07-02 2006-09-19 Diversa Corp glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
FR2857375B1 (fr) * 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
CA2956645A1 (en) 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
WO2005007663A2 (en) * 2003-07-14 2005-01-27 Irm Llc Fluorogenic enzyme substrates and uses thereof
WO2005007678A2 (en) * 2003-07-14 2005-01-27 Irm Llc Methods for the preparation of rhodamine
US20050019944A1 (en) * 2003-07-23 2005-01-27 Eastman Kodak Company Colorable microspheres for DNA and protein microarray
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
US20050059054A1 (en) 2003-07-25 2005-03-17 Richard Conrad Methods and compositions for preparing RNA from a fixed sample
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
US8114978B2 (en) 2003-08-05 2012-02-14 Affymetrix, Inc. Methods for genotyping selected polymorphism
US20070038386A1 (en) * 2003-08-05 2007-02-15 Schadt Eric E Computer systems and methods for inferring casuality from cellular constituent abundance data
US20050100911A1 (en) * 2003-08-06 2005-05-12 Perlegen Sciences, Inc. Methods for enriching populations of nucleic acid samples
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
WO2005021714A2 (en) 2003-08-11 2005-03-10 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
US20070026406A1 (en) * 2003-08-13 2007-02-01 Iconix Pharmaceuticals, Inc. Apparatus and method for classifying multi-dimensional biological data
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
KR100561842B1 (ko) * 2003-08-25 2006-03-16 삼성전자주식회사 단량체 광산발생제 조성물, 상기 조성물로 코팅된 기판,상기 단량체 광산발생제 조성물을 이용하여 기판상에서화합물을 합성하는 방법 및 상기 방법에 의하여 제조된마이크로어레이
CN102241742B (zh) * 2003-08-28 2014-04-02 奥索-麦克尼尔药品公司 结合血小板生成素受体的肽和化合物
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
US7217582B2 (en) 2003-08-29 2007-05-15 Rochester Institute Of Technology Method for non-damaging charge injection and a system thereof
US7287328B2 (en) 2003-08-29 2007-10-30 Rochester Institute Of Technology Methods for distributed electrode injection
JP3824233B2 (ja) * 2003-09-01 2006-09-20 セイコーエプソン株式会社 バイオセンサ及びバイオセンサの製造方法
US8131475B2 (en) 2003-09-03 2012-03-06 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for identifying, diagnosing, and predicting survival of lymphomas
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
CA2537254A1 (en) 2003-09-03 2005-03-17 Government Of The United States Of America, As Represented By Secretary, Department Of Health And Human Services Methods for identifying, diagnosing, and predicting survival of lymphomas
US7269517B2 (en) * 2003-09-05 2007-09-11 Rosetta Inpharmatics Llc Computer systems and methods for analyzing experiment design
US20050053949A1 (en) * 2003-09-08 2005-03-10 Silin Vitalii Ivanovich Biochip for proteomics applications
EP2824190A1 (en) 2003-09-09 2015-01-14 Integrigen, Inc. Methods and compositions for generation of germline human antibody genes
US7365179B2 (en) * 2003-09-09 2008-04-29 Compass Genetics, Llc Multiplexed analytical platform
CA2536565A1 (en) * 2003-09-10 2005-05-12 Althea Technologies, Inc. Expression profiling using microarrays
GB0321295D0 (en) * 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
US20050084914A1 (en) * 2003-09-15 2005-04-21 Foulkes J. G. Assays with primary cells
US20050164300A1 (en) * 2003-09-15 2005-07-28 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
WO2005029040A2 (en) * 2003-09-18 2005-03-31 Parallele Biosciences, Inc. System and methods for enhancing signal-to-noise ratios of microarray-based measurements
US7317521B2 (en) * 2003-09-18 2008-01-08 Micron Technology, Inc. Particle detection method
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
US20070111209A1 (en) * 2003-09-19 2007-05-17 Soley Bjornsdottir Inversion on chromosome 8p23 is a risk factor for anxiety disorders, depression and bipolar disorders
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
AU2004276761B2 (en) 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP2609919A3 (en) * 2003-09-26 2014-02-26 Exelixis, Inc. c-Met modulators and methods of use
US20070051626A1 (en) * 2003-09-26 2007-03-08 Chiho Itou Cataphoresis apparatus cataphoresis method, and detection method for organism-related material using the apparatus and the method
JP4111223B2 (ja) * 2003-09-26 2008-07-02 株式会社ニコン 環境保持装置および環境制御型分析装置
EP2469439A2 (en) 2003-09-29 2012-06-27 Pathwork Diagnostics, Inc. Systems and methods for detecting biological features
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
FR2860518B1 (fr) * 2003-10-01 2006-02-17 Biomerieux Sa Procede pour le diagnostic/pronostic du neuroblastome
DE10346286B3 (de) 2003-10-06 2005-04-14 J. Eberspächer GmbH & Co. KG Abgasreinigungsanordnung
ATE466106T1 (de) 2003-10-10 2010-05-15 Deutsches Krebsforsch Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehen
US20070274988A1 (en) * 2003-10-10 2007-11-29 Five Prime Therapeautics, Inc. Kiaa0779, Splice Variants Thereof, and Methods of Their Use
US20050227251A1 (en) 2003-10-23 2005-10-13 Robert Darnell Method of purifying RNA binding protein-RNA complexes
JP2007521017A (ja) 2003-10-28 2007-08-02 バイオアレイ ソリューションズ リミテッド 固定化捕捉プローブを用いる遺伝子発現分析法の最適化
WO2005040163A1 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
CA2544178A1 (en) * 2003-10-30 2005-05-19 Tufts-New England Medical Center Prenatal diagnosis using cell-free fetal dna in amniotic fluid
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
WO2005042716A2 (en) * 2003-10-31 2005-05-12 President And Fellows Of Harvard College Nucleic acid binding oligonucleotides
US20050095600A1 (en) * 2003-10-31 2005-05-05 Xiang Yu Methods of generating gene-specific probes for nucleic acid array detection
US20070212688A1 (en) * 2003-11-04 2007-09-13 Martin Dugas Method For Distinguishing Cbf-Positive Aml Subtypes From Cbf-Negative Aml Subtypes
EP1533618A1 (en) * 2003-11-04 2005-05-25 Ludwig-Maximilians-Universität München Method for distinguishing prognostically definable AML
EP1682898A2 (en) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Method for distinguishing aml subtypes with recurring genetic aberrations
WO2005045437A2 (en) * 2003-11-04 2005-05-19 Roche Diagnostics Gmbh Method for distinguishing immunologically defined all subtypes
US20050287668A1 (en) * 2003-11-04 2005-12-29 Cell Therapeutics, Inc. (Cti) RNA interference compositions and screening methods for the identification of novel genes and biological pathways
US20070212734A1 (en) * 2003-11-04 2007-09-13 Martin Dugas Method for Distinguishing T(11Q23)/Mll-Positive Leukemias From t(11Q23)/Mll Negative Leukemia
EP1682901A2 (en) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Method for distinguishing leukemia subtypes
WO2005043167A2 (en) * 2003-11-04 2005-05-12 Roche Diagnostic Gmbh Method for distinguishing aml subtypes with differents gene dosages
US20070212687A1 (en) * 2003-11-04 2007-09-13 Martin Dugas Method For Distinguishing Mll-Ptd-Positive Aml From Other Aml Subtypes
EP1530046A1 (en) * 2003-11-04 2005-05-11 Ludwig-Maximilians-Universität München Method for distinguishing AML subtypes with aberrant and prognostically intermediate karyotypes
US20070292970A1 (en) * 2003-11-04 2007-12-20 Martin Dugas Method for Distinguishing Aml-Specific Flt3 Length Mutations From Tkd Mutations
EP1685395A2 (en) * 2003-11-05 2006-08-02 EXACT Sciences Corporation Repetitive reversed-field affinity electrophoresis and uses therefor
JP2007512811A (ja) * 2003-11-10 2007-05-24 インベスチゲン, インコーポレイテッド 検出のための核酸を調製する方法
WO2005049848A2 (en) * 2003-11-12 2005-06-02 Geneohm Sciences, Inc. Nucleic acid hybridization methods
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US8367324B2 (en) * 2003-11-17 2013-02-05 Canon Kabushiki Kaisha Method for judging change in probe-bearing substrate, probe-bearing substrate and detecting apparatus
KR100543705B1 (ko) * 2003-11-20 2006-01-20 삼성전자주식회사 2차원적 격자가 형성되어 있는 기판을 포함하는 마이크로 어레이 및 그를 이용하는 표적 분자의 검출방법
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
KR100580631B1 (ko) * 2003-11-22 2006-05-16 삼성전자주식회사 산화막을 갖는 기판, 그를 이용한 표적 물질 검출 방법 및광학적 센서
US7456968B2 (en) * 2003-11-24 2008-11-25 General Electric Company Sensor system and methods for improved quantitation of environmental parameters
US20050112587A1 (en) * 2003-11-25 2005-05-26 Sherrill James V. Analyzing biological probes
EP1709198B1 (en) 2003-11-26 2013-08-14 AdvanDx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
AU2004294567A1 (en) 2003-11-26 2005-06-16 University Of Massachusetts Sequence-specific inhibition of small RNA function
EP1697534B1 (en) 2003-12-01 2010-06-02 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
US7824857B2 (en) * 2003-12-02 2010-11-02 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
KR100695123B1 (ko) * 2003-12-03 2007-03-14 삼성전자주식회사 Tm에 따라 기판상에 고정화된 프로브 폴리뉴클레오티드군을 2이상 포함하는 폴리뉴클레오티드 어레이 및 그를이용하는 표적 핵산 검출 방법
JP2005173484A (ja) * 2003-12-15 2005-06-30 Canon Inc 画像形成装置及びプロセスカートリッジ
WO2005058471A2 (en) * 2003-12-15 2005-06-30 Applera Corporation Automated oligomer synthesis
KR100601936B1 (ko) * 2003-12-17 2006-07-14 삼성전자주식회사 접착부 지지체와 2이상의 접착물질을 갖는 마이크로어레이반응 챔버용 패취
US20050136538A1 (en) * 2003-12-17 2005-06-23 Srikant Pathak Lithographic method for attaching biological cells to a solid substrate using a small molecule linker
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
US7504509B2 (en) * 2003-12-19 2009-03-17 Plexxikon, Inc. Compounds and methods for development of Ret modulators
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
CA2490675A1 (en) * 2003-12-22 2005-06-22 Affymetrix, Inc. Process for high-yield synthesis of standard length and long-mer nucleic acid arrays
DE602004028513D1 (de) 2003-12-23 2010-09-16 Mount Sinai Hospital Corp Verfahren zum nachweis von mit endometrialer krankheit oder phase assoziierten markern
CA2552007A1 (en) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US20080233564A1 (en) * 2004-01-08 2008-09-25 The Ohio State University Methods of Using Databases to Greate Gene-Expression Microarrays, Microarrays Greated Thereby, and Uses of the Microarrays
KR100580642B1 (ko) * 2004-01-12 2006-05-16 삼성전자주식회사 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이
JP2007518422A (ja) 2004-01-21 2007-07-12 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 変異体ナトリウムチャンネルNaν1.7およびそれに関連する方法
WO2005070020A2 (en) * 2004-01-23 2005-08-04 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
US20080113874A1 (en) * 2004-01-23 2008-05-15 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
DE602005001850T2 (de) * 2004-01-26 2008-04-17 Nimblegen Systems, Inc., Madison Computersoftware zur unterstützung der identifikation von snps mit microarrays
WO2005071058A2 (en) * 2004-01-27 2005-08-04 Compugen Ltd. Methods and systems for annotating biomolecular sequences
WO2005071059A2 (en) * 2004-01-27 2005-08-04 Compugen Ltd. Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
ATE451478T1 (de) * 2004-02-12 2009-12-15 Population Genetics Technologi Genetische analyse mittels sequenzspezifischem sortieren
US20050272059A1 (en) * 2004-02-12 2005-12-08 Xiaolian Gao Method for providing microarrays
JP4464158B2 (ja) * 2004-02-13 2010-05-19 キヤノン株式会社 生化学反応カートリッジ
KR100580644B1 (ko) 2004-02-16 2006-05-16 삼성전자주식회사 생물분자를 고체 기판상에 비공유적으로 고정화 하는 방법및 그에 의하여 제조되는 마이크로어레이
WO2005079357A2 (en) * 2004-02-17 2005-09-01 Dana Farber Cancer Institute Nucleic acid representations utilizing type iib restriction endonuclease cleavage products
CA2497324A1 (en) 2004-02-17 2005-08-17 Affymetrix, Inc. Methods for fragmenting and labelling dna
US8581308B2 (en) 2004-02-19 2013-11-12 Rochester Institute Of Technology High temperature embedded charge devices and methods thereof
US7981604B2 (en) 2004-02-19 2011-07-19 California Institute Of Technology Methods and kits for analyzing polynucleotide sequences
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
WO2005082425A1 (en) 2004-02-24 2005-09-09 The General Hospital Corporation Catalytic radiofluorination
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
WO2005084254A2 (en) * 2004-02-27 2005-09-15 Musc Foundation For Research Development Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20050209785A1 (en) * 2004-02-27 2005-09-22 Wells Martin D Systems and methods for disease diagnosis
JP2007534320A (ja) * 2004-02-27 2007-11-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ ポリヌクレオチド合成法
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
GB0404578D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
US20080139395A1 (en) * 2004-03-04 2008-06-12 Ryoichi Imanaka Microarray and Spotting Apparatus
KR100590550B1 (ko) * 2004-03-12 2006-06-19 삼성전자주식회사 동일한 표적핵산에 결합하는 프로브 폴리뉴클레오티드사이의 거리가 최대가 되도록 배열되어 있는마이크로어레이 및 그를 제조하는 방법
EP1735097B1 (en) 2004-03-12 2016-11-30 Life Technologies Corporation Nanoliter array loading
US7425426B2 (en) 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
US7560268B2 (en) * 2004-03-17 2009-07-14 Panasonic Corporation Process for manufacturing biochip, probe solution, and biochip
WO2005090972A1 (ja) * 2004-03-18 2005-09-29 Nissui Pharmaceutical Co., Ltd. 生物学的物質の分析キット、分析装置及び分析方法
JP4545189B2 (ja) 2004-03-24 2010-09-15 トライパス イメイジング インク 子宮頸部疾患を検出するための方法及び組成物
US20050269523A1 (en) * 2004-03-24 2005-12-08 Macaulay Calum E Light modulated microarray reader and methods relating thereto
US7265366B2 (en) * 2004-03-31 2007-09-04 Asml Netherlands B.V. Lithographic apparatus and device manufacturing method
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20090111702A1 (en) * 2004-04-06 2009-04-30 Mount Sinai School Of Medicine Office Of Industrial Liason Methods of determining allergen response using microarray immunoassay techniques
CA2562285A1 (en) * 2004-04-08 2006-03-16 Nimblegen Systems, Inc. Comparative genomic resequencing
KR100624420B1 (ko) * 2004-04-10 2006-09-19 삼성전자주식회사 마이크로어레이에 대한 정보가 스팟의 형태로 저장되어있는 마이크로어레이, 그를 제조하는 방법 및 그를이용하는 방법
US20050226535A1 (en) * 2004-04-13 2005-10-13 Srinka Ghosh Method and system for rectilinearizing an image of a microarray having a non-rectilinear feature arrangement
EP1737982A4 (en) * 2004-04-14 2009-09-23 Harvard College NUCLEIC ACID PROGRAMMABLE PROTEIN ARRANGEMENTS
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
WO2006001896A2 (en) * 2004-04-26 2006-01-05 Iconix Pharmaceuticals, Inc. A universal gene chip for high throughput chemogenomic analysis
WO2005113815A2 (en) * 2004-04-26 2005-12-01 Uab Research Foundation Polymorphisms in the fcgr2b promoter and uses thereof
US20050244984A1 (en) * 2004-04-28 2005-11-03 Parker Russell A Methods and compositions for calibrating chemical array readers
WO2005107412A2 (en) * 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
KR100580649B1 (ko) 2004-04-30 2006-05-16 삼성전자주식회사 결합 특이성이 개선된 폴리뉴클레오티드 프로브, 상기프로브가 고정화되어 있는 마이크로어레이 및 상기프로브를 설계하는 방법
DE102004021904B4 (de) * 2004-05-04 2011-08-18 Carl Zeiss Microlmaging GmbH, 07745 Verfahren und Vorrichtung zur Erzeugung einer Analyseanordnung mit diskreten, separaten Messbereichen zur biologischen, biochemischen oder chemischen Analyse
US20050250108A1 (en) * 2004-05-04 2005-11-10 Jose Remacle Preparation method and use of micro-arrays supports for detection of multiple polynucleotide sequences with high sensitivity
DE102004022263A1 (de) 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE102005052713A1 (de) 2005-11-04 2007-05-16 Clondiag Chip Tech Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
CN101031293A (zh) 2004-05-06 2007-09-05 普莱希科公司 Pde4b抑制剂及其应用
US20050250147A1 (en) * 2004-05-10 2005-11-10 Macevicz Stephen C Digital profiling of polynucleotide populations
US20060010513A1 (en) * 2004-05-11 2006-01-12 Melville Mark W Oligonucleotide arrays to monitor gene expression and methods for making and using same
US8135595B2 (en) 2004-05-14 2012-03-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Computer systems and methods for providing health care
US8911942B2 (en) * 2004-05-20 2014-12-16 Quest Diagnostics Investments Incorporated Single label comparative hybridization
ATE427499T1 (de) 2004-05-21 2009-04-15 Inst Systems Biology Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7635562B2 (en) 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
WO2005118129A1 (en) * 2004-05-27 2005-12-15 Stratos Biosystems, Llc Solid-phase affinity-based method for preparing and manipulating an analyte-containing solution
WO2005117553A2 (en) * 2004-05-27 2005-12-15 The Regents Of The University Of Colorado Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
JP5435864B2 (ja) 2004-05-28 2014-03-05 アシュラジェン インコーポレイテッド マイクロrnaに関与する方法および組成物
US7302348B2 (en) 2004-06-02 2007-11-27 Agilent Technologies, Inc. Method and system for quantifying and removing spatial-intensity trends in microarray data
US7338763B2 (en) * 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
US20090081243A1 (en) 2004-06-03 2009-03-26 Athlomics Pty Ltd. Agents and methods for diagnosing stress
JP3952042B2 (ja) * 2004-06-07 2007-08-01 ソニー株式会社 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるdnaチップ
US8273579B2 (en) * 2004-06-08 2012-09-25 Bizpac (Australia) Pty. Ltd. Method and apparatus for inspecting biological samples
WO2005124650A2 (en) * 2004-06-10 2005-12-29 Iconix Pharmaceuticals, Inc. Sufficient and necessary reagent sets for chemogenomic analysis
WO2006009676A2 (en) 2004-06-16 2006-01-26 Diversa Corporation Compositions and methods for enzymatic decolorization of chlorophyll
KR100634505B1 (ko) * 2004-06-16 2006-10-16 삼성전자주식회사 패턴화된 박막층을 갖는 마이크로어레이 기판 및마이크로어레이, 상기 마이크로어레이 기판 및마이크로어레이를 제조하는 방법
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
WO2006009755A2 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
JP2008503222A (ja) * 2004-06-18 2008-02-07 ニンブルゲン システムズ インコーポレイテッド 可変長プローブ選択
WO2006002191A1 (en) * 2004-06-21 2006-01-05 Nimblegen Systems, Inc. Probe optimization methods
US8034553B2 (en) 2004-06-24 2011-10-11 Kimberly-Clark Worldwide, Inc. Biomarkers for wound healing
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US20060003335A1 (en) * 2004-06-30 2006-01-05 Crispino John D Methods for diagnosing acute megakaryoblastic leukemia
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US20060004527A1 (en) * 2004-07-01 2006-01-05 Sampas Nicholas M Methods, systems and computer readable media for identifying dye-normalization probes
WO2006017150A2 (en) * 2004-07-09 2006-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatiion Identification of markers in lung and breast cancer
US20060009038A1 (en) * 2004-07-12 2006-01-12 International Business Machines Corporation Processing for overcoming extreme topography
US20060014680A1 (en) * 2004-07-13 2006-01-19 Caiding Xu Peptides and compounds that bind to the IL-5 receptor
JP4756835B2 (ja) * 2004-07-14 2011-08-24 キヤノン株式会社 生化学反応カートリッジ
US7588892B2 (en) * 2004-07-19 2009-09-15 Entelos, Inc. Reagent sets and gene signatures for renal tubule injury
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
WO2006007664A1 (en) * 2004-07-22 2006-01-26 Genomics Research Partners Pty Ltd Agents and methods for diagnosing osteoarthritis
WO2006022628A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
CN101087890A (zh) * 2004-07-26 2007-12-12 帕拉列勒生物科学公司 多个基因组的同时分析
CN101031655A (zh) 2004-07-26 2007-09-05 陶氏环球技术公司 通过株工程改进蛋白表达的方法
US8563328B2 (en) * 2004-07-26 2013-10-22 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
FR2873697B1 (fr) * 2004-07-28 2006-10-27 Commissariat Energie Atomique Agents de couplage a groupement protecteur photolabile et leurs utilisations, notamment pour la fonctionnalisation de supports solides
EP1782315A4 (en) * 2004-07-30 2009-06-24 Rosetta Inpharmatics Llc FORECAST FOR BREAST CANCER PATIENTS
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7393903B2 (en) * 2004-08-04 2008-07-01 Guerry Grune Devices and methods for the rapid, reliable detection and determination of acrylamide concentration in food substances and prevention of acrylamide formation in the same
US12070731B2 (en) 2004-08-04 2024-08-27 Life Technologies Corporation Methods and systems for aligning dispensing arrays with microfluidic sample arrays
US20060105453A1 (en) * 2004-09-09 2006-05-18 Brenan Colin J Coating process for microfluidic sample arrays
JP5140421B2 (ja) 2004-08-06 2013-02-06 ジェネンテック, インコーポレイテッド バイオマーカーを用いたアッセイおよび方法
EP1623996A1 (en) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Improved method of selecting a desired protein from a library
MX2007001469A (es) 2004-08-06 2007-03-26 Genentech Inc Ensayos y metodos que utilizan biomarcadores.
US20060210542A1 (en) * 2004-08-16 2006-09-21 Yurkow Edward J Use of TPO mimetic compounds and pharmaceutical compositions in the treatment of anemia
US20090087848A1 (en) * 2004-08-18 2009-04-02 Abbott Molecular, Inc. Determining segmental aneusomy in large target arrays using a computer system
WO2006023769A2 (en) * 2004-08-18 2006-03-02 Abbott Molecular, Inc. Determining data quality and/or segmental aneusomy using a computer system
CA2577755C (en) * 2004-08-19 2014-05-13 Biogen Idec Ma Inc. Neublastin variants
DE602005022082D1 (de) 2004-08-19 2010-08-12 Biogen Idec Inc Rückfaltung von proteinen der transforming-growth-factor-beta-familie
WO2006023312A2 (en) * 2004-08-20 2006-03-02 Carl Deirmengian Diagnostic assay for source of inflammation
KR100657896B1 (ko) * 2004-08-20 2006-12-14 삼성전자주식회사 Uv 필름을 이용한 활성기 또는 프로브 분자가고정화되어 있는 기판의 보관 방법, uv 필름을 이용한마이크로어레이의 제조방법 및 uv 필름이 부착된 기판
US20060046252A1 (en) * 2004-08-30 2006-03-02 Srinka Ghosh Method and system for developing probes for dye normalization of microarray signal-intensity data
WO2006130165A2 (en) * 2004-09-02 2006-12-07 Vialogy Corp. Detecting events of interest using quantum resonance interferometry
US7323308B2 (en) * 2004-09-03 2008-01-29 Affymetrix, Inc. Methods of genetic analysis of E. coli
US7504365B2 (en) 2004-09-03 2009-03-17 Receptors Llc Combinatorial artificial receptors including tether building blocks
CN101048407A (zh) * 2004-09-03 2007-10-03 普莱希科公司 双环杂芳基pde4b抑制剂
US7312035B2 (en) * 2004-09-03 2007-12-25 Affymetrix, Inc. Methods of genetic analysis of yeast
US7645575B2 (en) 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US7985715B2 (en) * 2004-09-11 2011-07-26 Receptors Llc Combinatorial artificial receptors including peptide building blocks
KR100682891B1 (ko) * 2004-09-14 2007-02-15 삼성전자주식회사 프로브 세트를 설계하는 방법, 그에 의하여 설계된프로브가 고정화된 기판을 갖는 마이크로어레이 및 상기방법을 컴퓨터가 수행할 수 있도록 하는 프로그램을기록한 컴퓨터 판독가능한 매체
FI20041204A0 (fi) 2004-09-16 2004-09-16 Riikka Lund Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi
EP1647600A3 (en) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Methods for identifying biological samples by addition of nucleic acid bar-code tags
ES2322175T3 (es) * 2004-09-17 2009-06-17 EISAI R&amp;D MANAGEMENT CO., LTD. Composicion medicinal con estabilidad mejorada y gelificacion reducida.
US7406391B2 (en) * 2004-09-20 2008-07-29 Affymetrix, Inc. System, method, and computer product for detection instrument calibration
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US7314542B2 (en) * 2004-09-23 2008-01-01 Nanogen, Inc. Methods and materials for optimization of electronic transportation and hybridization reactions
FR2876116B1 (fr) * 2004-10-01 2007-04-06 Biomerieux Sa Methode pour generer des transcrits
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
CA2582137A1 (en) * 2004-10-05 2007-02-15 Wyeth Probe arrays for detecting multiple strains of different species
JP5269412B2 (ja) 2004-10-07 2013-08-21 アルゴス セラピューティクス,インコーポレイティド 成熟樹状細胞組成物およびその培養方法
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7571055B2 (en) * 2004-10-13 2009-08-04 Regents Of The University Of Minnesota Systemic lupus erythematosus
FR2876705B1 (fr) * 2004-10-19 2008-12-12 Biomerieux Sa Procede pour le diagnostic d'une intolerance a l'aspirine
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
JP2006126204A (ja) 2004-10-29 2006-05-18 Affymetrix Inc ポリマーアレイを製造するための自動化方法
WO2006050479A2 (en) 2004-11-01 2006-05-11 George Mason University Compositions and methods for diagnosing colon disorders
US20060094024A1 (en) * 2004-11-01 2006-05-04 Pirrung Michael C Electrochemical arrays
JP3927978B2 (ja) * 2004-11-02 2007-06-13 キヤノン株式会社 生化学反応カートリッジおよび生化学処理装置システム
NZ554895A (en) * 2004-11-03 2009-06-26 Almac Diagnostics Ltd Transcriptome microarray technology and methods of using the same
US20090118132A1 (en) * 2004-11-04 2009-05-07 Roche Molecular Systems, Inc. Classification of Acute Myeloid Leukemia
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
WO2006060148A2 (en) * 2004-11-11 2006-06-08 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US11105808B2 (en) 2004-11-12 2021-08-31 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
DK2302055T3 (da) 2004-11-12 2014-10-13 Asuragen Inc Fremgangsmåder og sammensætninger involverende miRNA og miRNA-inhibitormolekyler
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060105355A1 (en) * 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer having a linker moiety
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
EP1812714B1 (de) * 2004-11-19 2008-03-26 ebm-papst St. Georgen GmbH & Co. KG Anordnung mit einem luefter und einer pumpe
KR100695134B1 (ko) * 2004-11-25 2007-03-14 삼성전자주식회사 층류를 이용한 마이크로어레이 및 이의 제조 방법
DE102004056980A1 (de) * 2004-11-25 2006-06-01 Clondiag Chip Technologies Gmbh Verfahren zur ortsspezifischen Synthese von Biopolymeren auf festen Trägern
EP1831684A4 (en) * 2004-11-30 2009-03-11 Veridex Llc PROGNOSTICS OF LUNG CANCER
US7647186B2 (en) * 2004-12-07 2010-01-12 Illumina, Inc. Oligonucleotide ordering system
JP4455306B2 (ja) * 2004-12-13 2010-04-21 キヤノン株式会社 生化学処理方法
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
EP2290369B1 (en) 2004-12-22 2013-08-14 California Institute Of Technology Methods for proteomic profiling using non-natural amino acids
KR100763906B1 (ko) * 2004-12-23 2007-10-05 삼성전자주식회사 9 종의 박테리아의 표적 서열을 특이적으로 증폭할 수 있는 프라이머 세트 및 상기 9 종의 박테리아 중 각 표적 서열에 특이적으로 혼성화하는 프로브 올리고뉴클레오티드
US20060147943A1 (en) * 2004-12-30 2006-07-06 Lewis Mark A Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
MX2007008065A (es) * 2004-12-30 2008-03-04 Todd M Hauser Composiciones y metodos para modular la expresion genica usando oligonucleotidos autoprotegidos.
US8338093B2 (en) * 2004-12-31 2012-12-25 Affymetrix, Inc. Primer array synthesis and validation
US7547775B2 (en) 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
CA2594458C (en) 2005-01-10 2016-08-23 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
US20060166224A1 (en) * 2005-01-24 2006-07-27 Norviel Vernon A Associations using genotypes and phenotypes
US20060183893A1 (en) * 2005-01-25 2006-08-17 North Don A Nucleic acids for apoptosis of cancer cells
AU2005325716A1 (en) * 2005-01-25 2006-08-03 Sky Genetics, Inc. Nucleic acids for apoptosis of cancer cells
ATE491941T1 (de) * 2005-01-27 2011-01-15 Quest Diagnostics Invest Inc Schnelle komparative genomhybridisierung
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
WO2006083751A2 (en) * 2005-01-31 2006-08-10 Pacific Biosciences Of California, Inc. Use of reversible extension terminator in nucleic acid sequencing
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
JP2008528040A (ja) 2005-02-01 2008-07-31 アジェンコート バイオサイエンス コーポレイション ビーズベースの配列決定のための試薬、方法およびライブラリー
EP2236628A3 (en) 2005-02-01 2010-10-13 AB Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
US7405831B2 (en) * 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7402730B1 (en) 2005-02-03 2008-07-22 Lexicon Pharmaceuticals, Inc. Knockout animals manifesting hyperlipidemia
CA2600199A1 (en) 2005-02-04 2006-08-10 Nimblegen Systems, Inc. Optimized probe selection method
US7407757B2 (en) * 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20090068650A1 (en) * 2005-02-11 2009-03-12 Southern Illinois University Metabolic Primers for the Detection of (Per) Chlorate-Reducing Bacteria and Methods of Use Thereof
NZ595305A (en) 2005-02-14 2013-06-28 Univ Iowa Res Found Methods and reagents for treatment and diagnosis of age-related macular degeneration
WO2006089095A2 (en) 2005-02-17 2006-08-24 Biogen Idec Ma Inc. Treating neurological disorders
US8178291B2 (en) 2005-02-18 2012-05-15 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
EP1848437A4 (en) * 2005-02-18 2012-04-25 Surface Logix Inc METHOD FOR PRODUCING PHARMACOKINETIC IMPROVED COMPOUNDS WITH FUNCTIONAL RESTORATIONS OR GROUPS AND PHARMACEUTICAL COMPOSITIONS WITH THESE COMPOUNDS
EP2333117B1 (en) 2005-02-18 2013-10-16 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods for detecting progression of low grade cervical dysplasia
CN102351862A (zh) * 2005-02-18 2012-02-15 表面线段公司 药动学改善的化合物
US20090215028A1 (en) * 2005-02-18 2009-08-27 Ellen Paxinos Methods and Compositions for Determining Anti-HIV Drug Susceptibility and Replication Capacity of HIV
WO2006089268A2 (en) * 2005-02-18 2006-08-24 The University Of North Carolina At Chapel Hill Gene and cognate protein profiles and methods to determine connective tissue markers in normal and pathologic conditions
WO2006091676A2 (en) * 2005-02-22 2006-08-31 Ceres Inc. Modulating plant alkaloids
JP2006242925A (ja) 2005-03-07 2006-09-14 Seiko Epson Corp 電極基板、該基板を備える検出装置および該装置を含むキット、並びに該キットを用いた検出方法
JP2006242926A (ja) 2005-03-07 2006-09-14 Seiko Epson Corp 電極基板、該基板を備える検出装置および該装置を含むキット、並びに該キットを用いた検出方法
KR101138864B1 (ko) * 2005-03-08 2012-05-14 삼성전자주식회사 프라이머 및 프로브 세트를 설계하는 방법, 그에 의하여 설계된 프라이머 및 프로브 세트, 상기 세트를 포함하는 키트, 상기 방법을 컴퓨터가 수행할 수 있도록 하는 프로그램을기록한 컴퓨터 판독가능한 매체 및 상기 세트를 이용한 표적 서열의 동정 방법
CA2614769A1 (en) 2005-03-10 2006-09-21 Verenium Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
US20100221186A1 (en) 2005-03-11 2010-09-02 Hueseyin Firat Biomarkers for cardiovascular side-effects induced by cox-2 inhibitory compounds
CA2600845A1 (en) * 2005-03-11 2006-09-21 The Regents Of The University Of Colorado Histone deacetylase inhibitors sensitize cancer cells to epidermal growth factor inhibitors
EP2604703B1 (en) 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Methods for evaluating graft survival in a solid organ transplant recipient
NZ594810A (en) 2005-03-15 2012-12-21 Verenium Corp Cellulases, nucleic acids encoding them and methods for making and using them
EP1856293A2 (en) * 2005-03-16 2007-11-21 Compass Genetics, Llc Methods and compositions for assay readouts on multiple analytical platforms
WO2006101487A1 (en) * 2005-03-18 2006-09-28 The Board Of Trustees Of The Leland Stanford Junior University Production and therapeutic uses of th1-like regulatory t cells
EP2518161A1 (en) 2005-03-18 2012-10-31 Fluidigm Corporation Method for detection of mutant alleles
JP2008532559A (ja) 2005-03-19 2008-08-21 メディカル リサーチ カウンシル ウイルス感染の治療及び予防又は治療及び予防の改善
EP2491926B1 (en) 2005-03-22 2018-05-09 President and Fellows of Harvard College Treatment of protein degradation disorders
US20070092886A1 (en) * 2005-03-22 2007-04-26 Raymond Tabibiazar Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease
WO2006102547A2 (en) 2005-03-23 2006-09-28 Bio-Rad Laboratories, Inc. Method for purifying proteins
US20090264635A1 (en) * 2005-03-25 2009-10-22 Applera Corporation Methods and compositions for depleting abundant rna transcripts
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
EP1863519B1 (en) 2005-03-31 2013-09-25 The General Hospital Corporation Modulating hgf/hgfr activity for treating lymphodema
EP1863908B1 (de) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
CN101965190A (zh) * 2005-04-04 2011-02-02 维里德克斯有限责任公司 乳腺肿瘤的激光显微解剖和微阵列分析揭示雌激素受体相关的基因和途径
US20060246576A1 (en) * 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US20090220495A1 (en) 2005-04-07 2009-09-03 Abdallah Fanidi Cancer Related Genes (PRLR)
US20090214536A1 (en) 2005-04-07 2009-08-27 Guoying Yu CACNA1E in Cancer Diagnosis, Detection and Treatment
JP2008535496A (ja) 2005-04-08 2008-09-04 ナステック ファーマスーティカル カンパニー インク. 呼吸器ウィルス感染用RNAi治療因子
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
EP3770278A1 (en) 2005-04-14 2021-01-27 The Trustees of Boston University Diagnostic for lung disorders using class prediction
US9394167B2 (en) * 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
WO2006112709A2 (en) * 2005-04-18 2006-10-26 Dsm Ip Assets B.V. Biochip and process for the production of a biochip
WO2006115575A1 (en) * 2005-04-20 2006-11-02 Ceres Inc. Regulatory regions from papaveraceae
US20060240443A1 (en) * 2005-04-20 2006-10-26 Combimatrix Corporation Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
JP5002584B2 (ja) * 2005-04-26 2012-08-15 バイエル・テクノロジー・サービシズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 親和性検定方法による分析試料検出用の基質をコーティングするための新規な装置および方法
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
US7452671B2 (en) * 2005-04-29 2008-11-18 Affymetrix, Inc. Methods for genotyping with selective adaptor ligation
US20060269948A1 (en) * 2005-05-16 2006-11-30 Halloran Philip F Tissue rejection
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
JP5227167B2 (ja) 2005-05-18 2013-07-03 デコード・ジェネティクス・イーエイチエフ Chr8q24.21での変異体は癌のリスクを与える
AU2006247134B2 (en) 2005-05-18 2012-05-10 Novartis Ag Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component
US7666596B2 (en) * 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
CA2618429A1 (en) 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
US20090087841A1 (en) * 2005-05-27 2009-04-02 Monogram Biosciences, Inc. Methods and compositions for determining resistance of hiv-1 to protease inhibitors
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US7919461B2 (en) * 2005-06-03 2011-04-05 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
US8324159B2 (en) * 2005-06-03 2012-12-04 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2006133266A2 (en) 2005-06-06 2006-12-14 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to hiv entry inhibitors
WO2006133267A2 (en) * 2005-06-06 2006-12-14 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs
US8940143B2 (en) 2007-06-29 2015-01-27 Intel Corporation Gel-based bio chip for electrochemical synthesis and electrical detection of polymers
CA2610875A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
US8053774B2 (en) * 2005-06-06 2011-11-08 Intel Corporation Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis
EP1731620A1 (en) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for the diagnosis of immune graft tolerance
WO2006133461A1 (en) * 2005-06-08 2006-12-14 Ceres Inc. Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations
JP4697944B2 (ja) * 2005-06-10 2011-06-08 キヤノン株式会社 非特異吸着を低減するプローブ固定担体の製造方法
US9410889B2 (en) * 2005-06-10 2016-08-09 Applied Biosystem, Llc Method and system for multiplex genetic analysis
US7368242B2 (en) * 2005-06-14 2008-05-06 Affymetrix, Inc. Method and kits for multiplex hybridization assays
US8053627B2 (en) * 2005-06-14 2011-11-08 University Of Chicago Methods for treating demyelination disorders
US7884260B2 (en) * 2005-06-14 2011-02-08 University Of Chicago Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination
US7423194B2 (en) * 2005-06-14 2008-09-09 University Of Chicago Animal models for demyelination disorders
US20090264299A1 (en) 2006-02-24 2009-10-22 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
US8445194B2 (en) 2005-06-15 2013-05-21 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
EA016397B1 (ru) * 2005-06-20 2012-04-30 Декоуд Дженетикс Ехф. Генетические варианты гена tcf7l2 как диагностические маркеры риска возникновения сахарного диабета ii типа
WO2007002433A1 (en) * 2005-06-22 2007-01-04 Plexxikon, Inc. Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
US20060292576A1 (en) * 2005-06-23 2006-12-28 Quest Diagnostics Investments Incorporated Non-in situ hybridization method for detecting chromosomal abnormalities
EP1736780A1 (en) 2005-06-24 2006-12-27 Eppendorf Array Technologies S.A. Method and means for detecting and/or quantifying hierarchical molecular change of a cell in response to an external stimulus
JP4789518B2 (ja) * 2005-06-30 2011-10-12 キヤノン株式会社 製造条件付きプローブ固定担体を用いた標的物質の検出方法ならびにそのための装置、キット及びシステム
CA2614042A1 (en) 2005-07-06 2007-01-11 Biochip Innovations Pty Ltd A method and kit for analyzing a target nucleic acid sequence
EP1910565A4 (en) 2005-07-07 2009-10-28 Athlomics Pty Ltd POLYNUCLEOTIDE MARKER GENES AND THEIR EXPRESSION IN THE DIAGNOSIS OF ENDOTOXEMIA
CN1908189A (zh) * 2005-08-02 2007-02-07 博奥生物有限公司 体外辅助鉴定肠型胃癌及其分化程度的方法与专用试剂盒
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
WO2007016502A2 (en) 2005-08-02 2007-02-08 Wisconsin Alumni Research Foundation Synthesis of arrays of oligonucleotides and other chain molecules
CA2617606A1 (en) * 2005-08-04 2007-02-15 Helicos Biosciences Corporation Multi-channel flow cells
US20080219890A1 (en) * 2005-08-04 2008-09-11 Helicos Biosciences Corporation Sample loading and recovery
SI2327792T1 (sl) * 2005-08-05 2013-12-31 Genentech, Inc. Postopki in sestavki za detektiranje avtoimunskih motenj
US20070037169A1 (en) * 2005-08-09 2007-02-15 Combimatrix Corporation Selective Dehybridization using Electrochemically-Generated Reagent on an Electrode Microarray
WO2007021744A1 (en) * 2005-08-10 2007-02-22 Arena Pharmaceuticals, Inc. Methods for determining probability of an adverse or favorable reaction to a niacin receptor agonist
CN101356285A (zh) * 2005-08-16 2009-01-28 梅洛根有限责任公司 鉴定陨石色基因的方法
CA2619759A1 (en) 2005-08-16 2007-02-22 Genentech, Inc. Apoptosis sensitivity to ap02l/trail by testing for galnac-t14 expression in cells/tissues
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
WO2007026864A1 (ja) * 2005-09-01 2007-03-08 Eisai R & D Management Co., Ltd. 崩壊性の改善された医薬組成物の製造方法
WO2007028147A2 (en) * 2005-09-01 2007-03-08 Philadelphia Health & Education Corporation D.B.A. Drexel University College Of Medicin Identification of a prostatic intraepithelial neoplasia (pin)-specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
JP2007078399A (ja) * 2005-09-12 2007-03-29 Tokyo Institute Of Technology 固体支持体及びdnaチップ
US7713689B2 (en) 2005-09-15 2010-05-11 Duke University Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
US7608395B2 (en) * 2005-09-15 2009-10-27 Baylor Research Institute Systemic lupus erythematosus diagnostic assay
US7551294B2 (en) * 2005-09-16 2009-06-23 University Of Rochester System and method for brewster angle straddle interferometry
ES2525545T3 (es) 2005-09-19 2014-12-26 Janssen Diagnostics, Llc Métodos y usos para identificar el origen de un carcinoma de origen primario desconocido
US20070065877A1 (en) * 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US20070231794A1 (en) 2005-09-21 2007-10-04 Combimatrix Corporation Process to detect binding events on an electrode microarray using enzymes
WO2007037926A2 (en) * 2005-09-23 2007-04-05 Sharp Laboratories Of America, Inc. Mems pixel sensor
US8855955B2 (en) 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
US20100062137A1 (en) * 2005-09-30 2010-03-11 Steven Craig Bobzin Modulating plant tocopherol levels
US7312079B1 (en) 2005-10-06 2007-12-25 Lexicon Pharmaceuticals, Inc. Variants of FAM3C
US7960104B2 (en) * 2005-10-07 2011-06-14 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
EP2546360A1 (en) 2005-10-07 2013-01-16 Callida Genomics, Inc. Self-assembled single molecule arrays and uses thereof
EP1941057A4 (en) * 2005-10-07 2009-11-11 Baylor Res Inst DIAGNOSIS OF THE SYSTEMIC OUTBREAK OF JUVENIL IDIOPATHIC ARTHRITIS ABOUT BLOOD LEUKOCYTE MICROARRAY ANALYSIS
WO2007047408A2 (en) * 2005-10-12 2007-04-26 Pathologica, Llc. Promac signature application
US20090178160A1 (en) * 2005-10-25 2009-07-09 Joon-Hyun Park Modulation of Triterpenoid Content in Plants
US7842823B2 (en) * 2005-10-27 2010-11-30 The Regents Of The University Of California Fluorogenic probes for reactive oxygen species
EP3591069A3 (en) 2005-10-27 2020-03-04 The President and Fellows of Harvard College Methods and compositions for labeling nucleic acids
AU2005337803B2 (en) 2005-10-29 2013-04-18 Bayer Intellectual Property Gmbh Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
US7749704B2 (en) 2005-11-01 2010-07-06 Mayo Foundation For Medical Education And Research Promoter polymorphisms of the BLyS gene and use in diagnostic methods
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US20090053236A1 (en) 2005-11-07 2009-02-26 Eisai R & D Management Co., Ltd. USE OF COMBINATION OF ANTI-ANGIOGENIC SUBSTANCE AND c-kit KINASE INHIBITOR
RU2008123384A (ru) 2005-11-16 2009-12-27 Новартис АГ (CH) БИОМАРКЕРЫ ДЛЯ ЛЕЧЕНИЯ АНТИТЕЛОМ к Nogo-A ПРИ ПОВРЕЖДЕНИЯХ СПИННОГО МОЗГА
US7576037B2 (en) * 2005-11-18 2009-08-18 Mei Technologies, Inc. Process and apparatus for combinatorial synthesis
US7291471B2 (en) * 2005-11-21 2007-11-06 Agilent Technologies, Inc. Cleavable oligonucleotide arrays
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US20070122842A1 (en) * 2005-11-30 2007-05-31 Rajasekaran John J Massively parallel synthesis of proteinaceous biomolecules
US7998717B2 (en) 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US7634363B2 (en) 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
RU2008127252A (ru) 2005-12-08 2010-01-20 Новартис АГ (CH) Эффекты ингибиторов fgfr3 на транскрипцию генов
US7994098B2 (en) * 2005-12-09 2011-08-09 Wisconsin Alumni Research Foundation Light directed DNA synthesis using inverse capping for error reduction
US20090215055A1 (en) * 2005-12-13 2009-08-27 Erasmus University Medical Center Rotterdam Genetic Brain Tumor Markers
US20070196843A1 (en) * 2005-12-13 2007-08-23 Green Roland D Method for identification and monitoring of epigenetic modifications
US8014957B2 (en) * 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
US20090305248A1 (en) * 2005-12-15 2009-12-10 Lander Eric G Methods for increasing accuracy of nucleic acid sequencing
US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
KR100738083B1 (ko) * 2005-12-20 2007-07-12 삼성전자주식회사 마이크로어레이용 기판 및 그의 제조방법
US8841255B2 (en) * 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
ES2779992T3 (es) 2005-12-20 2020-08-21 Univ Duke Métodos y composiciones para suministrar agentes activos con propiedades farmacológicas potenciadas
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
WO2007075026A1 (en) * 2005-12-27 2007-07-05 Samsung Electronics Co., Ltd Primers, probes, microarray, and method for specific detection of nine respiratory disease-associated bacterial species
AU2006342447B2 (en) 2005-12-28 2013-06-20 Translational Therapeutics, Inc Translational dysfunction based therapeutics
WO2007081664A2 (en) * 2005-12-29 2007-07-19 Affymetrix, Inc. Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
US20070154923A1 (en) * 2005-12-29 2007-07-05 Affymetrix, Inc. Method for Gridding and Quality Control of Polymer Arrays
US20070154946A1 (en) * 2005-12-29 2007-07-05 Rajasekaran John J Massively parallel synthesis of biopolymeric arrays
US20070255054A1 (en) * 2005-12-30 2007-11-01 Affymetrix, Inc. Oligonucleotide synthesis with intermittent and post synthetic oxidation
US20070198653A1 (en) * 2005-12-30 2007-08-23 Kurt Jarnagin Systems and methods for remote computer-based analysis of user-provided chemogenomic data
KR100829574B1 (ko) * 2006-01-03 2008-05-14 삼성전자주식회사 마이크로어레이용 기판, 그 마이크로어레이용 기판을이용하여 생분자를 분석하는 방법, 및 그 마이크로어레이용기판을 포함하는 랩온어칩
US7709227B2 (en) * 2006-01-04 2010-05-04 Phasebio Pharmaceuticals, Inc. Multimeric ELP fusion constructs
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
EP2952894B1 (en) * 2006-01-17 2017-08-30 Somalogic, Inc. Kits comprising aptamers
US20070168197A1 (en) * 2006-01-18 2007-07-19 Nokia Corporation Audio coding
NZ569697A (en) 2006-01-20 2012-01-12 Women S & Children S Health Res Inst Method of treatment, prophylaxis and diagnosis of pathologies of the bone by the modulation of GPC3
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20090143238A1 (en) * 2006-01-23 2009-06-04 Junghuei Chen Oligonucleotide matrix and methods of use
US20070172852A1 (en) * 2006-01-24 2007-07-26 Affymetrix, Inc. Non-destructive Quality Control Methods for Microarrays
WO2007087377A2 (en) * 2006-01-25 2007-08-02 Massachusetts Institute Of Technology Photoelectrochemical synthesis of high density combinatorial polymer arrays
US9445025B2 (en) 2006-01-27 2016-09-13 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
BRPI0707249A2 (pt) 2006-01-27 2011-04-26 Tripath Imaging Inc métodos para identificar pacientes com maior probabilidade de terem cáncer de ovário e composições para os mesmo
US8055098B2 (en) 2006-01-27 2011-11-08 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
CA2635343C (en) 2006-01-27 2018-05-15 Athena Diagnostics, Inc. Methods of detecting mutations associated with ataxia-ocular apraxia 2 (aoa2)
EP2216403A3 (en) 2006-02-02 2010-11-24 Verenium Corporation Esterases and related nucleic acids and methods
LT1986661T (lt) 2006-02-08 2018-12-10 Genzyme Corporation Nimano-piko a tipo ligos genų terapija
DK2420570T3 (en) 2006-02-10 2014-03-10 Bp Corp North America Inc Arabinofuranosidaseenzymer, nucleic acids encoding them, and methods for making and using them
BRPI0707784B1 (pt) 2006-02-14 2018-05-22 Verenium Corporation Ácido nucléico isolado, sintético ou recombinante, cassete de expressão, vetor ou veículo de clonagem, célula hospedeira isolada transformada, e método para produção de um polipeptídeo recombinante
CA2642273C (en) 2006-02-14 2016-09-20 President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
MX2008010462A (es) 2006-02-14 2009-04-17 Harvard College Inhibidores de histona desacetilasa.
GB0602992D0 (en) * 2006-02-15 2006-03-29 Morvus Technology Ltd Methods, genes and proteins
CA2642542C (en) 2006-02-16 2012-09-25 Ventana Medical Systems, Inc. Reagents and methods for cancer prognosis and pathological staging
US8492098B2 (en) * 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US20070199090A1 (en) * 2006-02-22 2007-08-23 Nestor Apuya Modulating alkaloid biosynthesis
EP1994180A4 (en) 2006-02-24 2009-11-25 Callida Genomics Inc GENOME SEQUENCING ON DNA ARRAYS WITH HIGH THROUGHPUT
TWI501774B (zh) * 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
PL2004843T3 (pl) 2006-02-28 2015-12-31 Univ Montana State Zastosowanie pochodnych fenantrydyny dla rozróżniania komórek nienaruszonych i komórek z uszkodzoną błoną za pomocą technik molekularnych opartych o kwas nukleinowy
ES2450065T3 (es) * 2006-03-01 2014-03-21 Biogen Idec Ma Inc. Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF
MX2008011442A (es) 2006-03-07 2008-11-18 Verenium Corp Aldolasas, acidos nucleicos que las codifican, y metodos para hacer y usar las mismas.
US8043837B2 (en) 2006-03-07 2011-10-25 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
JP2009529329A (ja) 2006-03-09 2009-08-20 トラスティーズ オブ ボストン ユニバーシティ 鼻腔上皮細胞の遺伝子発現プロファイルを用いた、肺疾患のための診断および予後診断の方法
WO2007106523A2 (en) * 2006-03-13 2007-09-20 Veridex, Llc Propagation of primary cells
US20100233350A1 (en) * 2006-03-15 2010-09-16 Boston Scientific Scimed, Inc. Drug delivery composition and methods of making same using nanofabrication
US7812206B2 (en) 2006-03-21 2010-10-12 Bp Corporation North America Inc. Apparatus and process for the separation of solids and liquids
CN101437536A (zh) 2006-03-23 2009-05-20 诺华有限公司 抗肿瘤细胞抗原抗体治疗
WO2007111937A1 (en) * 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
US20080009552A1 (en) * 2006-03-23 2008-01-10 Craig Pennell Markers of pre-term labor
EP1996947A1 (en) * 2006-03-24 2008-12-03 The Regents of the University of Michigan Method for forming molecular sequences on surfaces
US20080045471A1 (en) * 2006-03-27 2008-02-21 North Don A Nucleic Acids For Apoptosis Of Cancer Cells
US20080050747A1 (en) * 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) * 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US20070232556A1 (en) * 2006-03-31 2007-10-04 Montine Thomas J Methods and compositions for the treatment of neurological diseases and disorders
WO2007115207A2 (en) * 2006-03-31 2007-10-11 Regents Of The University Of Minnesota Irf-5 haplotypes in systemic lupus erythematosus
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
US20090222957A1 (en) * 2006-04-07 2009-09-03 Ceres Inc. Regulatory protein-regulatory region associations related to alkaloid biosynthesis
US7285388B1 (en) * 2006-04-07 2007-10-23 Merlogen, Llc Methods for identification of alport syndrome
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
WO2007121489A2 (en) * 2006-04-19 2007-10-25 Applera Corporation Reagents, methods, and libraries for gel-free bead-based sequencing
AR060536A1 (es) * 2006-04-20 2008-06-25 Glaxo Group Ltd Agonista del receptor de glucocorticoides y composiciones farmaceuticas
EP2537943B1 (en) * 2006-04-24 2014-03-12 Genentech, Inc. Methods and compositions for detecting autoimmune disorders
CA2650520A1 (en) * 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Treatment of ras-expressing tumors
EP2027291A2 (en) 2006-04-27 2009-02-25 Pikamab, Inc. Methods and compositions for antibody therapy
WO2007130434A2 (en) * 2006-05-02 2007-11-15 Applera Corporation Variable volume dispenser and method
CN101484156B (zh) * 2006-05-03 2015-11-25 哈佛大学校长及研究员协会 组蛋白脱乙酰基酶和微管蛋白脱乙酰基酶抑制剂
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
WO2007131103A2 (en) * 2006-05-03 2007-11-15 Quadraspec, Inc. Direct printing of patterned hydrophobic wells
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2481815B1 (en) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20090263798A1 (en) * 2006-05-15 2009-10-22 Generation Biotech, Llc Method For Identification Of Novel Physical Linkage Of Genomic Sequences
JP2007304043A (ja) * 2006-05-15 2007-11-22 Canon Inc プローブ固定担体の製造方法
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
WO2007136103A1 (ja) * 2006-05-18 2007-11-29 Eisai R & D Management Co., Ltd. 甲状腺癌に対する抗腫瘍剤
US20090325810A1 (en) 2006-05-22 2009-12-31 Clinical Genomics Pty. Ltd. Detection method
EP1862538A1 (en) * 2006-05-29 2007-12-05 IMBA-Institut für Molekulare Biotechnologie GmbH siRNA kinase and methods of use
WO2007139402A2 (en) * 2006-05-30 2007-12-06 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
US7713750B2 (en) * 2006-05-31 2010-05-11 The Johns Hopkins University Ablation based laser machining of biomolecule patterns on substrates
EP2602321B1 (en) 2006-05-31 2017-08-23 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
EP2029775B1 (en) * 2006-06-05 2014-10-15 California Institute Of Technology Real time micro arrays
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
CA2654165A1 (en) 2006-06-05 2007-12-13 Cancer Care Ontario Assessment of risk for colorectal cancer
WO2007146730A2 (en) 2006-06-08 2007-12-21 Gloucester Pharmaceuticals Deacetylase inhibitor therapy
EP2027253A4 (en) * 2006-06-12 2014-04-30 Pacific Biosciences California SUBSTATES FOR EFFECTING ANALYSIS REACTIONS
WO2007147079A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Rare cell analysis using sample splitting and dna tags
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
EP2366801B1 (en) 2006-06-14 2016-10-19 Verinata Health, Inc Methods for the diagnosis of fetal abnormalities
KR100954322B1 (ko) 2006-06-14 2010-04-21 주식회사 엘지생명과학 췌장암과 관련된 신규한 lbfl313 유전자
WO2007147110A2 (en) * 2006-06-16 2007-12-21 Pacific Biosciences Of California, Inc. Controlled initiation of primer extension
WO2007149696A1 (en) * 2006-06-23 2007-12-27 Applera Corporation Systems and methods for cooling in biological analysis instruments
US8009889B2 (en) * 2006-06-27 2011-08-30 Affymetrix, Inc. Feature intensity reconstruction of biological probe array
US8178316B2 (en) * 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
CA2656315A1 (en) * 2006-06-30 2008-01-10 Nugen Technologies, Inc. Methods for fragmentation and labeling of nucleic acids
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
EP2083264A1 (en) 2006-07-10 2009-07-29 Toto Ltd. Electrolyte-containing sheet for use in specific detection of analyte using photocurrent, and, employing the sheet, method of detection, sensor unit and measuring apparatus
DK2447275T3 (en) 2006-07-13 2015-06-29 Univ Iowa Res Found Methods and reagents for the treatment of age-related macular degeneration
AU2007273055B2 (en) 2006-07-14 2014-05-01 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US8213017B2 (en) * 2006-07-17 2012-07-03 Max Wiki Analytical system comprising an arrangement for temporally variable spatial light modulation and detection method executable therewith
US20080241951A1 (en) * 2006-07-20 2008-10-02 Visigen Biotechnologies, Inc. Method and apparatus for moving stage detection of single molecular events
WO2008009132A1 (en) * 2006-07-21 2008-01-24 The Governors Of The University Of Alberta Tissue rejection
KR100813262B1 (ko) * 2006-07-25 2008-03-13 삼성전자주식회사 광 촉매를 이용한 패터닝된 스팟 마이크로어레이의 제조방법 및 상기 방법에 의해 제조된 마이크로어레이
US20080026373A1 (en) * 2006-07-26 2008-01-31 Rodionova Natalia A Assays Based On Light Emission From Analyte Complexes Within A Cassette
WO2008013918A2 (en) * 2006-07-26 2008-01-31 Myelin Repair Foundation, Inc. Cell cycle regulation and differentiation
US7700756B2 (en) * 2006-07-27 2010-04-20 Southern Illinois University Metabolic primers for the detection of perchlorate-reducing bacteria and methods of use thereof
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) * 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
CN101529227B (zh) * 2006-08-03 2011-05-25 新加坡国立大学 微阵列系统和用于制备微阵列的方法
CN106222185B (zh) 2006-08-04 2021-12-03 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
EP2407559A3 (en) 2006-08-07 2012-03-21 Nsure Holding B.V. Genomics-based quality diagnostics for fresh agricultural products
TWI316873B (en) * 2006-08-08 2009-11-11 Ind Tech Res Inst Apparatus of manufacturing biochip and manufacture method of biochip tip array
US8586006B2 (en) 2006-08-09 2013-11-19 Institute For Systems Biology Organ-specific proteins and methods of their use
US7626185B2 (en) * 2006-08-11 2009-12-01 Battelle Memorial Institute Patterning compositions, masks, and methods
WO2008021431A2 (en) 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
KR100755672B1 (ko) * 2006-08-24 2007-09-05 삼성전자주식회사 기판 내에 형성된 프로브 셀 액티브를 포함하는 올리고머프로브 어레이 및 그 제조 방법
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
JP2010501577A (ja) * 2006-08-24 2010-01-21 サーフェイス ロジックス,インコーポレイティド 薬物動態が改善された化合物
WO2008026748A1 (fr) * 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US20080131893A1 (en) * 2006-08-31 2008-06-05 Mayo Foundation For Medical Education And Research Predicting Parkinson's Disease
EP4220138A1 (en) 2006-09-01 2023-08-02 Pacific Biosciences of California, Inc. Substrates, systems and methods for analyzing materials
US7985542B2 (en) * 2006-09-07 2011-07-26 Institut Pasteur Genomic morse code
EP1900824A1 (en) * 2006-09-14 2008-03-19 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Gene expression signature for the prognosis, diagnosis and therapy of prostate cancer and uses thereof
US20100021885A1 (en) * 2006-09-18 2010-01-28 Mark Fielden Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity
CA2663962A1 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir-31,mir-145, mir-147, mir-188, mir-215, mir-216, mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
EP2115138A2 (en) 2006-09-19 2009-11-11 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
GB0618514D0 (en) * 2006-09-20 2006-11-01 Univ Nottingham Trent Method of detecting interactions on a microarray using nuclear magnetic resonance
KR20090068266A (ko) 2006-09-21 2009-06-25 베레늄 코포레이션 포스포리파제, 그를 코딩하는 핵산 그리고 그를 제조 및 이용하는 방법
EP2617823B1 (en) 2006-09-21 2015-07-01 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
US8273539B2 (en) 2006-09-25 2012-09-25 Mayo Foundation For Medical Education And Research Extracellular and membrane-associated prostate cancer markers
KR100818275B1 (ko) * 2006-09-26 2008-03-31 삼성전자주식회사 노로바이러스의 표적 서열을 증폭하기 위한 프라이머 세트,노로바이러스의 표적 서열에 특이적으로 혼성화하는프로브 세트, 상기 프로브 세트가 고정화되어 있는마이크로어레이 및 상기 프로브 세트를 이용하여노로바이러스의 존재를 검출하는 방법
WO2008060362A2 (en) 2006-09-27 2008-05-22 The Regents Of The University Of California Methods and compositions for the treatment of skin diseases and disorders
FR2906537A1 (fr) * 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
KR100868760B1 (ko) * 2006-09-28 2008-11-17 삼성전자주식회사 그람 음성 및 양성 박테리아를 구별하기 위한 프라이머세트, 프로브 세트, 방법 및 키트
US9096953B2 (en) * 2006-09-29 2015-08-04 Intel Corporation Method for high throughput, high volume manufacturing of biomolecule micro arrays
KR100868765B1 (ko) * 2006-09-29 2008-11-17 삼성전자주식회사 항생제 내성 박테리아의 표적 서열을 증폭시킬 수 있는프라이머 세트, 박테리아의 표적 서열에 특이적으로혼성화하는 프로브 세트, 상기 프로브 세트가 고정화되어있는 마이크로어레이 및 상기 프로브 세트를 이용하여박테리아의 존재를 검출하는 방법
AU2007320026B2 (en) 2006-09-29 2014-04-03 Translational Therapeutics, Inc. eIF4E regulon-based diagnostics
US20100240544A1 (en) * 2006-09-29 2010-09-23 Liu David J Aptamer biochip for multiplexed detection of biomolecules
US20080079663A1 (en) * 2006-10-03 2008-04-03 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay precursor structure
US8236244B2 (en) * 2006-10-06 2012-08-07 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay structure with on-board addressable, pixel-specific functionalization
US8236245B2 (en) 2006-10-06 2012-08-07 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay precursor structure
US8231831B2 (en) * 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Micro-pixelated fluid-assay structure
US8232108B2 (en) * 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Method of making micro-pixelated fluid-assay structure
US8236571B2 (en) * 2006-10-06 2012-08-07 Sharp Laboratories Of America, Inc. Method of making micro-pixelated fluid-assay precursor structure
US8232109B2 (en) * 2006-10-06 2012-07-31 Sharp Laboratories Of America, Inc. Micro-pixelated active-matrix fluid-assay performance
CN101553579B (zh) 2006-10-06 2016-01-20 赛里根有限公司 用于定向生物标志物信号放大的荧光方法和材料
JP5143841B2 (ja) 2006-10-10 2013-02-13 ロス アラモス ナショナル セキュリティー,エルエルシー 高度な薬物開発及び製造
US20080167532A1 (en) * 2006-10-13 2008-07-10 Mayo Foundation For Medical Education And Research Assessing cancer treatment responsiveness
US20080090236A1 (en) * 2006-10-13 2008-04-17 Yakhini Zohar H Methods and systems for identifying tumor progression in comparative genomic hybridization data
CA2666584A1 (en) * 2006-10-17 2008-04-24 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US20080108149A1 (en) * 2006-10-23 2008-05-08 Narayan Sundararajan Solid-phase mediated synthesis of molecular microarrays
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
ES2465465T3 (es) 2006-11-01 2014-06-05 Ventana Medical Systems, Inc. Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso
DE102006035392A1 (de) 2006-11-02 2008-10-16 Signature Diagnostics Ag Prognostische Marker für die Vorhersage des fünfjährigen progressionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
WO2008058018A2 (en) 2006-11-02 2008-05-15 Mayo Foundation For Medical Education And Research Predicting cancer outcome
DE102006035388A1 (de) * 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung von Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
WO2008066655A2 (en) 2006-11-02 2008-06-05 Yale University Assessment of oocyte competence
DE102006035393A1 (de) 2006-11-02 2008-05-15 Signature Diagnostics Ag Prognostische Marker für die Klassifizierung des dreijährigen progessionsfreien Überlebens von Patienten mit Kolonkarzinomen basierend auf Expressionsprofilen von biologischen Proben
EP2080140B1 (en) 2006-11-03 2013-04-24 Baylor Research Institute Diagnosis of metastatic melanoma and monitoring indicators of immunosuppression through blood leukocyte microarray analysis
NZ551157A (en) * 2006-11-08 2008-06-30 Rebecca Lee Roberts Method of identifying individuals at risk of thiopurine drug resistance and intolerance - GMPS
US20090105961A1 (en) * 2006-11-09 2009-04-23 Complete Genomics, Inc. Methods of nucleic acid identification in large-scale sequencing
US20090111705A1 (en) 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by hybrid capture
EP2102367A2 (en) 2006-11-09 2009-09-23 XDX, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20080113915A1 (en) * 2006-11-09 2008-05-15 Duke University SAPAP3 knockout mouse and clinical modeling associated with the SAPAP3 gene
US8293481B2 (en) * 2006-11-10 2012-10-23 Mayo Foundation For Medical Education And Research Biomarkers for chronic vascular dysfunction
EP2089029B1 (en) 2006-11-10 2012-10-03 Massachusetts Institute of Technology Pak inhibitors for use in treating neurodevelopmental disorders
AU2007321678B2 (en) 2006-11-15 2014-03-20 The University Of British Columbia Polymorphisms predictive of anthracycline-induced cardiotoxicity
WO2008058395A1 (en) * 2006-11-15 2008-05-22 The University Of British Columbia Polymorphisms predictive of platinum-coordinating complex-induced ototoxicity
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US7791013B2 (en) * 2006-11-21 2010-09-07 Illumina, Inc. Biological microarray line scanning method and system
US7813013B2 (en) * 2006-11-21 2010-10-12 Illumina, Inc. Hexagonal site line scanning method and system
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
US8293684B2 (en) * 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
US9114398B2 (en) 2006-11-29 2015-08-25 Canon U.S. Life Sciences, Inc. Device and method for digital multiplex PCR assays
US20100291569A1 (en) * 2006-11-30 2010-11-18 Abbott Laboratories Assay for prediction of response to met antagonists
DK2099935T3 (da) * 2006-11-30 2014-04-07 Univ California Array for detektion af mikrober
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
JP2010510804A (ja) * 2006-11-30 2010-04-08 デコード・ジェネティクス・イーエイチエフ 2型糖尿病の遺伝的感受性変異体
US7807359B2 (en) * 2006-12-01 2010-10-05 Quest Diagnostics Investments Incorporated Methods of detecting TPMT mutations
US7989396B2 (en) * 2006-12-05 2011-08-02 The Board Of Trustees Of The Leland Stanford Junior University Biomolecule immobilization on biosensors
NZ577805A (en) * 2006-12-05 2012-09-28 Decode Genetics Ehf Genetic markers for risk management of cardiac arrhythmia
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
AU2007327993B2 (en) 2006-12-06 2013-06-20 Medimmune, Llc. Methods of treating systemic lupus erythematosus
EP2104737B1 (en) 2006-12-08 2013-04-10 Asuragen, INC. Functions and targets of let-7 micro rnas
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2677308B1 (en) 2006-12-14 2017-04-26 Life Technologies Corporation Method for fabricating large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
CA2673092A1 (en) * 2006-12-19 2008-06-26 Synergenz Bioscience Limited Methods and compositions for the assessment of cardiovascular function and disorders
US20080182328A1 (en) * 2006-12-19 2008-07-31 The Burnham Institute Mammalian extraembryonic endoderm cells and methods of isolation
US7622295B2 (en) * 2006-12-19 2009-11-24 Edelmira Cabezas Molecular microarrays and helical peptides
US20080153135A1 (en) * 2006-12-20 2008-06-26 Liu Timothy Z Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates
KR100834745B1 (ko) * 2006-12-20 2008-06-09 삼성전자주식회사 분석 친화적 레이아웃에 기반한 올리고머 프로브 어레이칩, 이의 제조에 사용되는 마스크 및 이의 혼성화 분석방법
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
WO2008079972A2 (en) 2006-12-20 2008-07-03 Bayer Healthcare Llc 4-{4- [ ({3-tert-butyl-1- [3- (hydroxymethyl) phenyl] - 1h- pyrazol- 5 -yl } carbamoyl) -amin o] -3-chlorophenoxy} -n-methylpyridine-2-carboxamide as an inhibitor of the vegfr kinase for the treatment of cancer
EP2094701A2 (en) 2006-12-21 2009-09-02 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
DK2479266T3 (en) 2006-12-21 2016-06-20 Basf Enzymes Llc Amylases and glucoamylases, nucleic acids encoding them, and methods of making and using the same
US20080153134A1 (en) * 2006-12-22 2008-06-26 Willy Wiyatno Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer
US7923237B2 (en) * 2006-12-28 2011-04-12 Intel Corporation Method and apparatus for combined electrochemical synthesis and detection of analytes
US8614086B2 (en) * 2006-12-28 2013-12-24 Intel Corporation Quality control methods for the manufacture of polymer arrays
US20080161202A1 (en) * 2006-12-29 2008-07-03 Edelmira Cabezas Novel strategy for selective regulation of background surface property in microarray fabrication and method to eliminated self quenching in micro arrays
US20100248975A1 (en) * 2006-12-29 2010-09-30 Gunjan Tiwari Fluorogenic peptide substrate arrays for highly multiplexed, real-time monitoring of kinase activities
WO2008085857A2 (en) 2007-01-04 2008-07-17 Children's Hospital Medical Center Processing text with domain-specific spreading activation methods
CA2674352A1 (en) * 2007-01-05 2008-07-17 Integrated Dna Technologies, Inc. Method for estimating melting temperature of a nucleic acid in buffers containing divalent ions
KR101443214B1 (ko) * 2007-01-09 2014-09-24 삼성전자주식회사 폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이
US8642295B2 (en) * 2007-01-11 2014-02-04 Erasmus University Medical Center Circular chromosome conformation capture (4C)
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
US7855054B2 (en) * 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US7659968B2 (en) 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
US20080175757A1 (en) * 2007-01-19 2008-07-24 Andrew Powell Microarray device with elastomeric well structure
US8664364B2 (en) 2007-01-24 2014-03-04 Carnegie Mellon University Optical biosensors
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US9164037B2 (en) * 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
KR101445892B1 (ko) * 2007-01-29 2014-09-29 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암 치료용 조성물
KR101483805B1 (ko) 2007-01-30 2015-01-16 파마시클릭스, 인코포레이티드 히스톤 데아세틸라제 억제제에 대한 암 내성을 확인하는 방법
WO2008095033A2 (en) 2007-01-30 2008-08-07 Verenium Corporation Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
SG193026A1 (en) 2007-02-07 2013-09-30 Decode Genetics Ehf Genetic variants contributing to risk of prostate cancer
KR100827449B1 (ko) * 2007-02-07 2008-05-07 삼성전자주식회사 광분해성 화합물과 상기 화합물이 커플링된 올리고머프로브 어레이용 기판, 올리고머 프로브 어레이 및 이의제조 방법
AU2008213634B2 (en) 2007-02-08 2013-09-05 Sequenom, Inc. Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
DK2471954T3 (en) * 2007-02-21 2016-09-12 Decode Genetics Ehf Susceptibility genetic variants associated with cardiovascular diseases
US9581595B2 (en) 2007-02-26 2017-02-28 Laboratory Corporation Of America Holdings Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
EP1961825A1 (en) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
EP2243834A1 (en) 2007-03-05 2010-10-27 Cancer Care Ontario Assessment of risk for colorectal cancer
US20080220537A1 (en) * 2007-03-07 2008-09-11 Pacific Biosciences Of California, Inc. Substrates and methods for selective immobilization of active molecules
WO2008112127A2 (en) * 2007-03-08 2008-09-18 Switchgear Genomics Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes
US20080228699A1 (en) 2007-03-16 2008-09-18 Expanse Networks, Inc. Creation of Attribute Combination Databases
US20080234143A1 (en) * 2007-03-23 2008-09-25 Pacific Biosciences Of California, Inc. Mechanical methods for producing substrates having selectively immobilized molecules
US7787126B2 (en) * 2007-03-26 2010-08-31 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US8652780B2 (en) 2007-03-26 2014-02-18 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
CN101874120B (zh) * 2007-03-26 2015-01-14 解码遗传学私营有限责任公司 作为用于乳腺癌风险评估、诊断、预后和治疗的标记的chr2和chr16的遗传性变型
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
US7572990B2 (en) * 2007-03-30 2009-08-11 Intermec Ip Corp. Keypad overlay membrane
EP2076289B1 (en) 2007-04-13 2014-11-12 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to erbb therapeutics
EP2137535B1 (en) * 2007-04-13 2015-06-03 Dana-Farber Cancer Institute, Inc. Receptor tyrosine kinase profiling
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2008128333A1 (en) * 2007-04-19 2008-10-30 The Governors Of The University Of Alberta A method to distinguish antibody-mediated tissue rejection from t cell-mediated tissue rejection
US20080268440A1 (en) * 2007-04-26 2008-10-30 Liu Timothy Z Biomolecule immobilization on surface via hydrophobic interactions
WO2008134571A1 (en) 2007-04-27 2008-11-06 University Of California Plant co2 sensors, nucleic acids encoding them, and methods for making and using them
KR101530395B1 (ko) 2007-04-27 2015-06-19 피페넥스 인크. 향상된 수율 및(또는) 품질로 이종 단백질을 발현하는 특정 균주를 동정하기 위해 미생물 숙주를 신속히 스크리닝하는 방법
US9580719B2 (en) * 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
DK2155907T3 (da) 2007-04-30 2015-08-31 Decode Genetics Ehf Genetiske varianter nyttige til risikovurdering af koronararteriesygdom og myokardieinfarkt
EP2142659A4 (en) 2007-04-30 2010-06-09 Univ Ohio State Res Found METHOD FOR THE DISTINCTION OF PANCREATIC CANCER OF NORMAL IMMERSION SPECTRUM FUNCTIONS AND CHRONIC IMMERSION IMAGING IGNITION
US20100197518A1 (en) 2007-05-01 2010-08-05 Huichun Xu Methods for Diagnosing Ischemia
WO2008137586A1 (en) * 2007-05-01 2008-11-13 University Of Miami Transcriptomic biomarkers for individual risk assessment in new onset heart failure
TWI445544B (zh) 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
AU2008247395A1 (en) 2007-05-03 2008-11-13 Medimmune, Llc Auto-antibody markers of autoimmune disease
US20080286881A1 (en) * 2007-05-14 2008-11-20 Apel William A Compositions and methods for combining report antibodies
US8200440B2 (en) * 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
WO2008153743A2 (en) * 2007-05-21 2008-12-18 Dana Farber Cancer Institute Compositions and methods for cancer gene discovery
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
NZ581858A (en) * 2007-05-25 2012-07-27 Decode Genetics Ehf Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
WO2008144827A1 (en) 2007-05-31 2008-12-04 The University Of Queensland Diagnostic markers for ankylosing spondylitis and uses thereof
US20080300796A1 (en) * 2007-05-31 2008-12-04 Lassahn Gordon D Biological analysis methods, biological analysis devices, and articles of manufacture
US20100093554A1 (en) * 2007-06-01 2010-04-15 Keting Chu Methods for identifying biomarkers, autoantibody signatures, and stratifying subject groups using peptide arrays
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
CA2688434A1 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
NZ581742A (en) 2007-06-08 2012-09-28 Biogen Idec Inc Biomarkers for predicting anti-tnf responsiveness or non-responsiveness
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
GB0713183D0 (en) * 2007-07-06 2007-08-15 King S College London Method
DE102007031526B4 (de) 2007-07-06 2010-07-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verwendung einer Anode in einer Brennstoffzelle zur Oxidation von Ethanol und/oder zumindest eines C3 bis C10-haltigen Alkohols
WO2009009662A1 (en) * 2007-07-10 2009-01-15 University Of South Florida Method of predicting non-response to first line chemotherapy
CA2692784C (en) 2007-07-12 2018-10-02 The Brigham And Women's Hospital, Inc. Compositions and methods for diagnosing and assessing inflammatory myopathies
US9289492B2 (en) 2007-07-17 2016-03-22 The General Hospital Corporation Collecting ovarian cancer stem cells from ovarian cancer cells
CN101808994B (zh) 2007-07-17 2013-05-15 普莱希科公司 用于激酶调节的化合物和方法以及其适应症
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
KR20090012582A (ko) * 2007-07-30 2009-02-04 삼성전자주식회사 기판 상에 폴리머를 합성하는 장치 및 그 방법
JP5659014B2 (ja) 2007-08-02 2015-01-28 ジリード バイオロジクス,インク. 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物
WO2009020964A2 (en) * 2007-08-08 2009-02-12 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
WO2009023676A1 (en) 2007-08-12 2009-02-19 Integrated Dna Technologies, Inc. Microarray system with improved sequence specificity
CA2694281A1 (en) * 2007-08-13 2009-02-19 Almac Diagnostics Limited A 3'-based sequencing approach for microarray manufacture
US20090136916A1 (en) * 2007-08-13 2009-05-28 Trustees Of Tufts College Methods and microarrays for detecting enteric viruses
CA2695064A1 (en) 2007-08-14 2009-02-19 F. Hoffmann-La Roche Ag Predictive markers for egfr inhibitors treatment
KR20100037637A (ko) 2007-08-14 2010-04-09 에프. 호프만-라 로슈 아게 Egfr 억제제 치료에 대한 예측 마커
JP5368445B2 (ja) 2007-08-14 2013-12-18 エフ.ホフマン−ラ ロシュ アーゲー Egfr阻害因子治療のための予測マーカー
MX2010001578A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Marcador predictivo para tratamiento con el inhibidor del receptor del factor de crecimiento epidermico.
EP2185195A2 (en) * 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
CA2697106A1 (en) * 2007-08-28 2009-03-12 Donald Bergstrom Expression profiles of biomarker genes in notch mediated cancers
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009029073A1 (en) 2007-08-30 2009-03-05 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
WO2009039122A2 (en) 2007-09-17 2009-03-26 Sequenom, Inc. Integrated robotic sample transfer device
WO2009039173A2 (en) 2007-09-19 2009-03-26 Applied Biosystems Inc. SiRNA SEQUENCE-INDEPENDENT MODIFICATION FORMATS FOR REDUCING OFF-TARGET PHENOTYPIC EFFECTS IN RNAi, AND STABILIZED FORMS THEREOF
JP2010539982A (ja) * 2007-10-01 2010-12-24 アプライド バイオシステムズ, エルエルシー チェイスライゲーション配列決定法
JP5744518B2 (ja) 2007-10-03 2015-07-08 ビーピー・コーポレーション・ノース・アメリカ・インコーポレーテッド キシラナーゼ、キシラナーゼをコードする核酸並びにそれらを製造及び使用する方法
US20090139311A1 (en) * 2007-10-05 2009-06-04 Applied Biosystems Inc. Biological Analysis Systems, Devices, and Methods
US20100216655A1 (en) * 2007-10-12 2010-08-26 Patrick Sulem Sequence variants for inferring human pigmentation patterns
WO2009052214A2 (en) * 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
US20100216119A1 (en) * 2007-10-15 2010-08-26 King's College London Diagnostic Methods for HIV Infection
AU2008316317B2 (en) 2007-10-23 2015-04-30 Clinical Genomics Pty. Ltd. A method of diagnosing neoplasms
EP2053132A1 (en) * 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
EP2215257A4 (en) 2007-10-23 2010-12-01 Clinical Genomics Pty Ltd METHOD FOR DIAGNOSING TUMOR DISEASES
US8298768B2 (en) * 2007-11-29 2012-10-30 Complete Genomics, Inc. Efficient shotgun sequencing methods
US7901890B2 (en) * 2007-11-05 2011-03-08 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
US8415099B2 (en) 2007-11-05 2013-04-09 Complete Genomics, Inc. Efficient base determination in sequencing reactions
US7897344B2 (en) * 2007-11-06 2011-03-01 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs
US8518640B2 (en) * 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8617811B2 (en) * 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
CA2739011A1 (en) * 2007-10-29 2009-05-07 The Regents Of The University Of California Osteoarthritis gene therapy
WO2009059022A1 (en) 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
JP4400668B2 (ja) 2007-11-01 2010-01-20 株式会社豊田中央研究所 微小物体が固定化された固相体の製造方法及びその利用
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
CA2704499C (en) 2007-11-07 2020-03-10 Genentech, Inc. Methods and compositions for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies
US8952035B2 (en) * 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
WO2009067657A2 (en) * 2007-11-21 2009-05-28 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Methods of identifying molecular function
US20090142759A1 (en) * 2007-11-29 2009-06-04 Erik Larsson qPCR array with IN SITU primer synthesis
US8093063B2 (en) * 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
WO2009073511A2 (en) * 2007-11-30 2009-06-11 Mayo Foundation For Medical Education And Research Polymorphisms of the blys gene and use in diagnostic methods
US8697360B2 (en) 2007-11-30 2014-04-15 Decode Genetics Ehf. Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition
DK2610351T3 (en) 2007-12-05 2015-09-28 Complete Genomics Inc Base efficient provision of sequencing reactions
US8592150B2 (en) 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
EP2229473A4 (en) * 2007-12-07 2011-02-02 Steven A Goldstein IDENTIFICATION OF TOXIN LIGANDS
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
EP2232271B1 (en) 2007-12-19 2019-09-11 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US20110003708A1 (en) * 2007-12-27 2011-01-06 Compugen Ltd. Biomarkers for the prediction of renal injury
EP2570500A3 (en) 2008-01-02 2013-04-03 Suregene Llc Genetic markers of mental illness
JP5563990B2 (ja) 2008-01-03 2014-07-30 ヴェレニウム コーポレイション トランスフェラーゼおよびオキシドレダクターゼ、それらをコードする核酸並びにそれらを製造および使用する方法
EP2581456A3 (en) 2008-01-17 2013-07-17 Suregene Llc Genetic Markers of Mental Illness
JP2011509689A (ja) * 2008-01-22 2011-03-31 ベリデックス・エルエルシー Ii及びiii期結腸癌の分子病期分類並びに予後診断
WO2009094583A1 (en) * 2008-01-23 2009-07-30 Complete Genomics, Inc. Methods and compositions for preventing bias in amplification and sequencing reactions
NZ587179A (en) 2008-01-25 2012-07-27 Theranostics Lab Detection of polymorphisms CYP2C19*17 and CYP2C19*3 in CYP2C19 gene related to antiplatelet drug metabolism (e.g. for clopidogrel metabolism)
US8658379B2 (en) 2008-01-29 2014-02-25 University of Pittsburgh—of the Commonwealth System of Higher Education Follistatin-like protein-1 as a biomarker for sepsis
WO2009097424A1 (en) * 2008-01-29 2009-08-06 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Fstl-1 as a biomarker of inflammation
US7763856B2 (en) * 2008-01-31 2010-07-27 Palo Alto Research Center Incorporated Producing time variation in emanating light
US8263955B2 (en) * 2008-12-18 2012-09-11 Palo Alto Research Center Incorporated Causing relative motion
US8153950B2 (en) * 2008-12-18 2012-04-10 Palo Alto Research Center Incorporated Obtaining sensing results and/or data in response to object detection
US7894068B2 (en) * 2008-02-04 2011-02-22 Palo Alto Research Center Incorporated Producing filters with combined transmission and/or reflection functions
US7701580B2 (en) * 2008-02-01 2010-04-20 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
CA2713667A1 (en) * 2008-01-31 2009-08-06 Compugen Ltd. Cd55 isoform and uses therof in cancer detection, monitoring and therapy
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
US8373860B2 (en) * 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
CA2618163A1 (en) 2008-02-07 2009-08-07 K. W. Michael Siu Head and neck cancer biomarkers
WO2009098485A1 (en) * 2008-02-07 2009-08-13 Forensic Sciences Service Ltd Improvements in and relating to analysis
US20090203531A1 (en) * 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
US8105777B1 (en) 2008-02-13 2012-01-31 Nederlands Kanker Instituut Methods for diagnosis and/or prognosis of colon cancer
EP2247755B1 (en) 2008-02-14 2015-01-28 Decode Genetics EHF Susceptibility variants for lung cancer
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
KR101030476B1 (ko) * 2008-03-11 2011-04-25 국립암센터 Snp 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법
US7932036B1 (en) 2008-03-12 2011-04-26 Veridex, Llc Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase
US20110071049A1 (en) 2008-03-12 2011-03-24 Nathaniel Heintz Methods and compositions for translational profiling and molecular phenotyping
US8623598B2 (en) * 2008-03-19 2014-01-07 Intelligent Bio Systems, Inc. Methods and compositions for inhibiting undesired cleaving of labels
US10745740B2 (en) 2008-03-19 2020-08-18 Qiagen Sciences, Llc Sample preparation
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
AU2009228312B2 (en) 2008-03-26 2015-05-21 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
EP2107125A1 (en) 2008-03-31 2009-10-07 Eppendorf Array Technologies SA (EAT) Real-time PCR of targets on a micro-array
US20090246788A1 (en) 2008-04-01 2009-10-01 Roche Nimblegen, Inc. Methods and Assays for Capture of Nucleic Acids
AU2009233327B2 (en) 2008-04-01 2014-11-13 Decode Genetics Ehf Susceptibility variants for peripheral arterial disease and abdominal aortic aneurysm
US20090270273A1 (en) * 2008-04-21 2009-10-29 Complete Genomics, Inc. Array structures for nucleic acid detection
WO2009130588A2 (en) 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
US20090269746A1 (en) * 2008-04-25 2009-10-29 Gil Atzmon Microsequencer-whole genome sequencer
US20110118125A1 (en) * 2008-05-03 2011-05-19 Tufts Medical Center, Inc. Neonatal salivary genomics
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
WO2009137521A2 (en) * 2008-05-07 2009-11-12 Illumina, Inc. Compositions and methods for providing substances to and from an array
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
EP2285960B1 (en) 2008-05-08 2015-07-08 Asuragen, INC. Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
EP2297347B1 (en) 2008-05-14 2017-03-08 Millennium Pharmaceuticals, Inc. Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
KR100956447B1 (ko) * 2008-05-16 2010-05-06 한국전자통신연구원 바이오센서의 기판의 패턴의 제조 방법 및 이를 이용한바이오센서
AU2009253675A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
US20090298082A1 (en) * 2008-05-30 2009-12-03 Klee George G Biomarker panels for predicting prostate cancer outcomes
WO2009143624A1 (en) 2008-05-30 2009-12-03 The University Of British Columbia Methods of diagnosing rejection of a kidney allograft using genomic or proteomic expression profiling
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
US20110159492A1 (en) * 2008-06-04 2011-06-30 Rimsza Lisa M Diffuse Large B-Cell Lymphoma Markers and Uses Therefore
EP2294420B8 (en) 2008-06-06 2015-10-21 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Survival predictor for diffuse large B cell lymphoma
US8791258B2 (en) * 2008-06-10 2014-07-29 The Regents Of The University Of California Pro-fluorescent probes
WO2010008480A2 (en) 2008-06-25 2010-01-21 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
EP4074327A1 (en) 2008-06-27 2022-10-19 Duke University Therapeutic agents comprising elastin-like peptides
AU2009265105A1 (en) * 2008-07-04 2010-01-07 Decode Genetics Ehf Copy number variations predictive of risk of schizophrenia
NZ590833A (en) 2008-07-07 2013-01-25 Decode Genetics Ehf Genetic variants for breast cancer risk assessment
WO2010004695A1 (ja) 2008-07-09 2010-01-14 パナソニック株式会社 シークエンサー
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010011296A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
US9182406B2 (en) * 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
WO2010018600A1 (en) * 2008-08-12 2010-02-18 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
US8530716B2 (en) * 2008-08-14 2013-09-10 Bp Corporation North America Inc. Melt-crystallization separation and purification process
WO2010018601A2 (en) * 2008-08-15 2010-02-18 Decode Genetics Ehf Genetic variants predictive of cancer risk
EP2631301B1 (en) 2008-08-18 2017-10-11 The Board of Trustees of the Leland Stanford Junior University Methods for determining a graft tolerant phenotype in a subject
KR20100025328A (ko) * 2008-08-27 2010-03-09 삼성전자주식회사 이중가닥 영역과 말단 단일가닥 영역을 포함하는 이중가닥 핵산 프로브가 고정된 마이크로어레이를 제조하는 방법
WO2010025310A2 (en) 2008-08-27 2010-03-04 Westend Asset Clearinghouse Company, Llc Methods and devices for high fidelity polynucleotide synthesis
CN102165315B (zh) 2008-08-29 2014-06-18 森托科尔奥索生物科技公司 用于使用20基因群组评估及治疗溃疡性结肠炎和相关疾病的标记物和方法
US8153391B2 (en) 2008-08-29 2012-04-10 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
US8357503B2 (en) 2008-08-29 2013-01-22 Bunge Oils, Inc. Hydrolases, nucleic acids encoding them and methods for making and using them
CA2737505C (en) 2008-09-16 2017-08-29 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
EP2344672B8 (en) 2008-09-25 2014-12-24 SureGene LLC Genetic markers for optimizing treatment for schizophrenia
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CA2742324A1 (en) 2008-10-30 2010-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods for assessing rna patterns
JP5502413B2 (ja) * 2008-10-31 2014-05-28 シスメックス株式会社 検査チップ、被検物質検出装置および被検物質の特異的検出方法
MX2011004588A (es) * 2008-10-31 2011-08-03 Abbott Lab Clasificacion genomica de carcinoma de pulmon de celulas no pequeñas basadas en patrones de alteraciones de numero de copias de gene.
US8498822B2 (en) * 2008-10-31 2013-07-30 Abbvie Inc. Genomic classification of colorectal cancer based on patterns of gene copy number alterations
MX2011004589A (es) * 2008-10-31 2011-05-25 Abbott Lab Metodos para ensamblar paneles de lineas de celulas de cancer para uso para probar la eficiencia de una o mas composiciones farmaceuticas.
MX2011004604A (es) * 2008-10-31 2011-05-25 Abbott Lab Clasificacion genomica de melanoma maligno con base en patrones de alteraciones de numero de copias de gene.
EP2352998A4 (en) 2008-11-07 2011-09-21 Centocor Ortho Biotech Inc MARKERS AND METHOD FOR THE STUDY AND TREATMENT OF LIGHT-SENSITIVELY LUPUS PATIENTS
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
BRPI0921043A2 (pt) 2008-11-12 2018-08-07 Caris Life Sciences Luxembourg Holdings métodos e sistemas para usar exossomas para determinar fenótipos
GB0820822D0 (en) 2008-11-13 2008-12-24 Inst Catala D Oncologia Novel product and processes
US20110287034A1 (en) 2008-11-14 2011-11-24 The Brigham And Womens Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
SG194383A1 (en) 2008-12-05 2013-11-29 Glaxo Group Ltd Methods for selecting protease resistant polypeptides
US20100151473A1 (en) * 2008-12-10 2010-06-17 Yeakley Joanne M Methods and compositions for hybridizing nucleic acids
US8039794B2 (en) 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
US8374818B2 (en) * 2008-12-19 2013-02-12 Affymetrix, Inc. System, method and apparatus for calibrating inspection tools
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
US20100161607A1 (en) * 2008-12-22 2010-06-24 Jasjit Singh System and method for analyzing genome data
EP2382472B1 (en) 2008-12-23 2015-05-06 F.Hoffmann-La Roche Ag Methods and compositions for diagnostic use in cancer patients
US8108406B2 (en) 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
EP2370929A4 (en) 2008-12-31 2016-11-23 23Andme Inc LOOKING FOR PARENTS IN A DATABASE
US8715732B2 (en) * 2009-01-05 2014-05-06 Cornell University Nucleic acid hydrogel via rolling circle amplification
CN102341505A (zh) * 2009-01-09 2012-02-01 英特拉克森公司 细胞的遗传学分析
US8788213B2 (en) 2009-01-12 2014-07-22 Intrexon Corporation Laser mediated sectioning and transfer of cell colonies
ES2726702T3 (es) 2009-01-15 2019-10-08 Adaptive Biotechnologies Corp Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
TW202241853A (zh) 2009-01-16 2022-11-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
WO2010085251A1 (en) 2009-01-22 2010-07-29 Momenta Pharmaceuticals, Inc. Galactose-alpha-1, 3-galactose-containing n-glycans in glycoprotein products derived from cho cells
KR20100086827A (ko) * 2009-01-23 2010-08-02 삼성전자주식회사 프로브 핵산의 서열을 분석하는 방법, 그를 위한 마이크로어레이 및 키트 및 프로브 핵산의 합성 효율을 결정하는 방법
WO2010087994A2 (en) 2009-01-30 2010-08-05 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
US8640555B2 (en) * 2009-02-09 2014-02-04 Bioaccel Performance
IL313131A (en) 2009-02-11 2024-07-01 Caris Mpi Inc Molecular characterization of tumors
US20100331204A1 (en) * 2009-02-13 2010-12-30 Jeff Jeddeloh Methods and systems for enrichment of target genomic sequences
WO2010096658A1 (en) 2009-02-19 2010-08-26 The Cleveland Clinic Foundation Corin as a marker for heart failure
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
EP2406399B1 (en) * 2009-03-09 2018-02-14 Bioatla, LLC Mirac proteins
JP5342421B2 (ja) * 2009-03-11 2013-11-13 信越化学工業株式会社 分子固定用基板の製造方法
WO2010107825A2 (en) 2009-03-16 2010-09-23 Pangu Biopharma Limited Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities
JP4826860B2 (ja) 2009-03-18 2011-11-30 Toto株式会社 光電流を用いた被検物質の特異的検出に用いられる測定装置、それに用いられるセンサユニット、および光電流を用いた被検物質の特異的検出方法
EP2408936A4 (en) * 2009-03-18 2013-01-30 Sequenom Inc USE OF HEAT-STAINED ENDONUCLEASES FOR THE PREPARATION OF REPORTER MOLECULES
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
WO2010111686A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Labeled enzyme compositions, methods & systems
EP2414541B8 (en) * 2009-03-31 2014-09-10 Centre Hospitalier Universitaire Vaudois Methylation ligation-dependent macroarray (mlm)
AU2010236913B2 (en) 2009-03-31 2016-03-24 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities
DK2414543T3 (en) 2009-04-03 2017-01-23 Decode Genetics Ehf Genetic markers for risk management of atrial fibrillation and stroke
EP2414545B1 (en) 2009-04-03 2017-01-11 Sequenom, Inc. Nucleic acid preparation compositions and methods
US9447089B2 (en) 2009-04-03 2016-09-20 Plexxikon Inc. Compositions and uses thereof
WO2010118243A2 (en) 2009-04-08 2010-10-14 Genentech, Inc. Use of il-27 antagonists to treat lupus
WO2010118264A2 (en) 2009-04-09 2010-10-14 California Institute Of Technology Multiplexed sites for polymer synthesis
JP5836929B2 (ja) 2009-04-18 2015-12-24 ジェネンテック, インコーポレイテッド 抗cd40抗体を用いる治療に対するb細胞性リンパ腫の応答性を評価するための方法
US20100330569A1 (en) 2009-04-23 2010-12-30 Intelligent Bio-Systems, Inc. Hydroxymethyl Linkers For Labeling Nucleotides
WO2010125566A2 (en) 2009-04-27 2010-11-04 Technion Research And Development Foundation Ltd. Markers for cancer detection
US9206482B2 (en) 2009-04-29 2015-12-08 Genomedx Biosciences Inc. Systems and methods for expression-based classification of thyroid tissue
EP2427575B1 (en) 2009-05-07 2018-01-24 Veracyte, Inc. Methods for diagnosis of thyroid conditions
WO2010129937A2 (en) * 2009-05-08 2010-11-11 Life Technologies Corporation Methods for detecting genetic variations in dna samples
WO2010128530A1 (en) * 2009-05-08 2010-11-11 Decode Genetics Ehf Genetic variants contributing to risk of prostate cancer
EP2253715A1 (en) 2009-05-14 2010-11-24 RWTH Aachen New targets for cancer therapy and/or diagnosis
JP2012527247A (ja) 2009-05-21 2012-11-08 ヴェレニウム コーポレイション フィターゼ、フィターゼをコードする核酸並びにその製造および使用方法
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
US20100298171A1 (en) * 2009-05-22 2010-11-25 Affymetrix, Inc. Apparatus for polymer synthesis
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
JP2012527895A (ja) 2009-05-29 2012-11-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 被移植者における免疫寛容に伴うb細胞の特性
US9200276B2 (en) 2009-06-01 2015-12-01 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent RNA interference, compositions and methods of use thereof
WO2010141546A1 (en) 2009-06-02 2010-12-09 University Of Miami Diagnostic transcriptomic biomakers in inflammatory cardiomyopathies
WO2010141390A2 (en) 2009-06-05 2010-12-09 Life Technologies Corporation Nucleotide transient binding for sequencing methods
US9524369B2 (en) 2009-06-15 2016-12-20 Complete Genomics, Inc. Processing and analysis of complex nucleic acid sequence data
CN102459592B (zh) 2009-06-15 2017-04-05 考利达基因组股份有限公司 用于长片段阅读测序的方法和组合物
US20120190574A1 (en) 2009-06-19 2012-07-26 The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona Compound Arrays for Sample Profiling
JP5359600B2 (ja) * 2009-06-24 2013-12-04 Jsr株式会社 酸転写樹脂組成物及びバイオチップの製造方法
WO2010151807A1 (en) 2009-06-26 2010-12-29 Sirigen, Inc. Signal amplified biological detection with conjugated polymers
WO2011006169A1 (en) 2009-07-10 2011-01-13 Portola Pharmaceuticals, Inc. Methods for diagnosis and treatment of thrombotic disorders mediated by cyp2c19*2
CA2767360A1 (en) 2009-07-10 2011-01-13 Decode Genetics Ehf. Genetic markers associated with risk of diabetes mellitus
BR112012000735A2 (pt) 2009-07-13 2016-11-16 Genentech Inc "métodos, kits e conjuntos de compostos"
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
JP2013501526A (ja) 2009-08-14 2013-01-17 ジェネンテック, インコーポレイテッド Vegfアンタゴニストに対する患者の応答をモニターするための生物学的マーカー
WO2011020091A1 (en) * 2009-08-14 2011-02-17 Phasebio Pharmaceuticals, Inc. Modified vasoactive intestinal peptides
US9771618B2 (en) * 2009-08-19 2017-09-26 Bioarray Genetics, Inc. Methods for treating breast cancer
CN104293646A (zh) 2009-08-22 2015-01-21 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
US20110124111A1 (en) 2009-08-31 2011-05-26 Life Technologies Corporation Low-volume sequencing system and method of use
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
WO2011032040A1 (en) 2009-09-10 2011-03-17 Centrillion Technology Holding Corporation Methods of targeted sequencing
US8815779B2 (en) 2009-09-16 2014-08-26 SwitchGear Genomics, Inc. Transcription biomarkers of biological responses and methods
US9410965B2 (en) * 2009-09-17 2016-08-09 Battelle Energy Alliance, Llc Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
US8969009B2 (en) * 2009-09-17 2015-03-03 Vicki S. Thompson Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
CA2772670A1 (en) 2009-09-17 2011-03-24 F. Hoffmann-La Roche Ag Methods and compositions for diagnostics use in cancer patients
CN102630250A (zh) 2009-09-25 2012-08-08 基因诊断测试公司 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试
TWI384554B (zh) * 2009-10-02 2013-02-01 Univ Southern Taiwan Tech 具三層式電極的微圓洞陣列之生物微粒控制晶片及其製造方法
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
HUE026447T2 (en) 2009-10-16 2016-05-30 Novartis Ag Pharmacodynamic tumor response biomarkers
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
WO2011048495A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
WO2011048499A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
US20120316080A1 (en) 2009-10-19 2012-12-13 Stichting Het Nederlands Kanker Instiuut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
EP2314714A1 (en) 2009-10-22 2011-04-27 Universiteit Leiden Disease susceptibility
US9644240B2 (en) 2009-10-22 2017-05-09 Leiden University Disease susceptibility
CA2778005A1 (en) 2009-10-26 2011-05-12 Abbott Laboratories Detection of chromosomal abnormalities associated with prognosis of non small cell lung cancer
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
EP2494069B1 (en) 2009-10-30 2013-10-02 Roche Diagniostics GmbH Method for detecting balanced chromosomal aberrations in a genome
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US7972793B2 (en) 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
JP2013509869A (ja) 2009-11-05 2013-03-21 ノバルティス アーゲー 線維症の進行の予測用バイオマーカー
UA105813C2 (uk) 2009-11-06 2014-06-25 Плексікон, Інк. Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти)
ES2605677T3 (es) 2009-11-11 2017-03-15 Momenta Pharmaceuticals, Inc. Glucosiltransferasa de hámster chino y métodos relacionados
US20110152267A1 (en) * 2009-11-12 2011-06-23 Texas Tech University System Compositions and Methods for Treating Hyperproliferative Disorders
EP2501414B1 (en) 2009-11-17 2018-01-10 The Trustees Of The University Of Pennsylvania Smndelta7 degron: novel compositions and methods of use
US8961989B2 (en) 2009-11-20 2015-02-24 Oregon Health & Science University Methods for producing an immune response to tuberculosis
AU2010321533A1 (en) * 2009-11-23 2012-05-31 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
EP3085791A1 (en) 2009-11-25 2016-10-26 Gen9, Inc. Methods and apparatuses for chip-based dna error reduction
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
US9290813B2 (en) 2009-12-02 2016-03-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US20110143966A1 (en) * 2009-12-15 2011-06-16 Affymetrix, Inc. Surface Modifications and Methods for their Synthesis and Use
GB0922085D0 (en) 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
DE102009059112A1 (de) 2009-12-18 2011-06-22 Biotype Diagnostic GmbH, 01109 Eine Vorrichtung zur Bestimmung molekularer Wechselwirkungen, sowie eine Folie zur Herstellung einer solchen
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
FR2954349A1 (fr) 2009-12-22 2011-06-24 Agronomique Inst Nat Rech Sulfatase modifiant selectivement les glycosaminoglycanes
GB0922377D0 (en) 2009-12-22 2010-02-03 Arab Gulf University The Mutant LDL receptor
AR079704A1 (es) 2009-12-23 2012-02-15 Genentech Inc Anticuerpos anti-bv8 y sus usos
CA2785406A1 (en) 2009-12-23 2011-06-30 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a canine
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US20120294954A1 (en) 2009-12-29 2012-11-22 Hill's Pet Nutrition, Inc Compositions including ginger for the amelioration or prevention of inflammatory conditions
CN102782156A (zh) 2009-12-31 2012-11-14 文塔纳医疗系统公司 用于生成独特特异性核酸探针的方法
WO2011085075A2 (en) 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
WO2011088226A2 (en) 2010-01-13 2011-07-21 Caris Life Sciences Luxembourg Holdings Detection of gastrointestinal disorders
EP2526138B1 (en) 2010-01-19 2024-02-28 Sirigen II Limited Novel reagents for directed biomarker signal amplification
US9927434B2 (en) 2010-01-20 2018-03-27 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
CA2787994C (en) 2010-01-26 2021-01-12 National Jewish Health Diagnosis and prognosis of idiopathic interstitial pneumonia by rs35705950 snp in muc5b gene promoter
EP2531261B1 (en) 2010-02-01 2016-08-31 The Board of Trustees of the Leland Stanford Junior University Methods for diagnosis and treatment of non-insulin dependent diabetes mellitus
PT2531880T (pt) 2010-02-01 2016-10-31 Illumina Inc Resumo
EP2534489A1 (en) 2010-02-10 2012-12-19 Novartis AG Methods and compounds for muscle growth
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9110025B2 (en) 2010-03-01 2015-08-18 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8716467B2 (en) 2010-03-03 2014-05-06 Gen9, Inc. Methods and devices for nucleic acid synthesis
EP2542678B1 (en) 2010-03-04 2017-04-12 InteRNA Technologies B.V. A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS THERAPEUTIC USES IN CANCER ASSOCIATED WITH EMT
DE202011003570U1 (de) 2010-03-06 2012-01-30 Illumina, Inc. Systeme und Vorrichtungen zum Detektieren optischer Signale aus einer Probe
EP2369325A1 (en) 2010-03-12 2011-09-28 Eppendorf Ag Array analysis for online detection
US9535075B2 (en) 2010-03-25 2017-01-03 The Board Of Trustees Of The Leland Stanford Junior University Protein and gene biomarkers for rejection of organ transplants
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2011127194A1 (en) 2010-04-06 2011-10-13 The George Washington University Compositions and methods for identifying autism spectrum disorders
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
MY161567A (en) 2010-04-16 2017-04-28 Zeus Scientific Inc Methods for measuring enzyme activity useful in determining cell viability in non-purified samples
CN103079567A (zh) 2010-04-17 2013-05-01 拜尔健康护理有限责任公司 用于疾病和病症的治疗和预防的氟取代的ω-羧基芳基二苯脲的合成代谢产物
CN102858265A (zh) 2010-04-19 2013-01-02 宝洁公司 针对调节哺乳动物皮肤状况的组合的能量和局部用组合物应用
BR112012026870A2 (pt) 2010-04-19 2017-01-10 Procter & Gamble assinaturas genéticas e chips de gene associados à administração de frequência de ráfsudio conduzida eletricamente à pele e métodos e tratamentos relacionados aos mesmos
WO2011139714A2 (en) 2010-04-26 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
EP2563381B1 (en) 2010-04-27 2017-08-09 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases
EP3508854A1 (en) 2010-04-27 2019-07-10 The Regents of The University of California Cancer biomarkers and methods of use thereof
EP2563911B1 (en) 2010-04-28 2021-07-21 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
US9034320B2 (en) 2010-04-29 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
US9598734B2 (en) 2010-04-29 2017-03-21 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy
EP2566496B1 (en) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
CA2797277C (en) 2010-05-03 2021-02-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
EP2566495B1 (en) 2010-05-03 2017-03-01 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
AU2011248101B2 (en) 2010-05-04 2016-10-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
US20120065085A1 (en) 2010-05-10 2012-03-15 Abbott Laboratories Detection of chromosomal abnormalities associated with endometrial cancer
US10240194B2 (en) 2010-05-13 2019-03-26 Gen9, Inc. Methods for nucleotide sequencing and high fidelity polynucleotide synthesis
AU2011252990B2 (en) 2010-05-14 2017-04-20 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
US9482664B2 (en) 2010-05-17 2016-11-01 Sentilus Holdco LLC Detection devices and related methods of use
WO2011146725A1 (en) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarkers for a multikinase inhibitor
EP2388336A1 (en) 2010-05-19 2011-11-23 Signature Diagnostics AG Method and kits for diagnosing colorectal cancer
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ, インコーポレイテッド グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US9187777B2 (en) 2010-05-28 2015-11-17 Gen9, Inc. Methods and devices for in situ nucleic acid synthesis
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
WO2011153224A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
MX2020004501A (es) 2010-06-03 2021-11-09 Pharmacyclics Llc El uso de inhibidores de la tirosina quinasa de bruton (btk).
US9228240B2 (en) 2010-06-03 2016-01-05 California Institute Of Technology Methods for detecting and quantifying viable bacterial endo-spores
WO2011150976A1 (en) 2010-06-04 2011-12-08 bioMérieux Method and kit for the prognosis of colorectal cancer
PL2576837T3 (pl) 2010-06-04 2018-04-30 Chronix Biomedical Krążeniowe biomarkery typu kwasu nukleinowego związane z rakiem prostaty
CN103119176A (zh) 2010-06-07 2013-05-22 霍夫曼-拉罗奇有限公司 用于预测对白介素-6受体抑制性单克隆抗体药物治疗的响应的基因表达标记
BR112012032240A2 (pt) 2010-06-16 2019-09-24 Dynavax Technologies Corporation método de tratamento utilizando inibidores tlr7 e/ou tlr9
US9353412B2 (en) 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
BR112012032462A2 (pt) 2010-06-25 2016-11-08 Eisai R&D Man Co Ltd agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.
TWI580955B (zh) 2010-06-30 2017-05-01 生命技術公司 離子感測電荷累積電路及方法
CN103080739B (zh) 2010-06-30 2016-12-21 生命科技公司 用于测试isfet阵列的方法和装置
US8432149B2 (en) 2010-06-30 2013-04-30 Life Technologies Corporation Array column integrator
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
JP5876044B2 (ja) 2010-07-03 2016-03-02 ライフ テクノロジーズ コーポレーション 低濃度ドープドレインを有する化学的感応性センサ
NZ704322A (en) 2010-07-06 2016-07-29 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ, インコーポレイテッド グリシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6049614B2 (ja) 2010-07-12 2016-12-21 セルジーン コーポレイション ロミデプシン固体形態及びそれらの使用
CA2803011C (en) 2010-07-16 2019-12-03 Tocagen Inc. Retrovirus detection
EP2601609B1 (en) 2010-08-02 2017-05-17 Population Bio, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
WO2012019099A2 (en) 2010-08-05 2012-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Follistatin-like-protein-1 as a biomarker for inflammatory disorders
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US8834847B2 (en) 2010-08-12 2014-09-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
US9040464B2 (en) 2010-08-16 2015-05-26 Mount Sinai Hosptial Markers of the male urogenital tract
DK2609216T3 (en) 2010-08-24 2016-09-12 Dana Farber Cancer Inst Inc Methods to predict anti-cancer response
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
BR122020021163B1 (pt) 2010-09-13 2021-03-16 Clinical Genomics Pty. Ltd. métodos de triagem de início ou predisposição para início de neoplasma do intestino grosso ou monitoramento do progresso de neoplasma em indivíduo
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
CN103299188B (zh) 2010-09-15 2017-03-15 阿尔玛克诊断有限公司 用于癌症的分子诊断试验
WO2012036679A1 (en) 2010-09-15 2012-03-22 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2012037456A1 (en) 2010-09-17 2012-03-22 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
EP2619326A2 (en) 2010-09-20 2013-07-31 Stichting Het Nederlands Kanker Instituut Methods for predicting response to anti-cancer therapy in cancer patients
EP2623613B8 (en) 2010-09-21 2016-09-07 Population Genetics Technologies Ltd. Increasing confidence of allele calls with molecular counting
EP2619564B1 (en) 2010-09-24 2016-03-16 Life Technologies Corporation Matched pair transistor circuits
US8759038B2 (en) 2010-09-29 2014-06-24 Illumina Cambridge Limited Compositions and methods for sequencing nucleic acids
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
CA2811789A1 (en) 2010-10-06 2012-04-12 Bp Corporation North America Inc. Variant cbh i polypeptides with reduced product inhibition
US20120095029A1 (en) 2010-10-15 2012-04-19 Hoffmann-La Roche Inc. Ipp complex as marker for erlotinib treatment
WO2012051476A1 (en) 2010-10-15 2012-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mid-infrared imaging of microarrays
EP2633069B1 (en) 2010-10-26 2015-07-01 Illumina, Inc. Sequencing methods
CA2819230A1 (en) 2010-10-28 2012-05-03 Yale University Methods and compositions for assessing and treating cancer
GB201018312D0 (en) 2010-10-29 2010-12-15 Vib Vzw Metagene expression signature for prognosis of breast cancer patients
EP2637780B1 (en) 2010-11-12 2022-02-09 Gen9, Inc. Protein arrays and methods of using and making the same
US9295965B2 (en) 2010-11-12 2016-03-29 Gen9, Inc. Methods and devices for nucleic acid synthesis
US9574173B2 (en) 2010-11-15 2017-02-21 Accelerated Biosciences Corp. Generation of neural stem cells from human trophoblast stem cells
JP6155194B2 (ja) 2010-11-17 2017-06-28 インターペース ダイアグノスティックス リミテッド ライアビリティ カンパニー 良性甲状腺新生物と悪性甲状腺新生物を区別するためのバイオマーカーとしてのmiRNA
AU2011333780A1 (en) 2010-11-24 2013-06-06 F. Hoffmann-La Roche Ag Methods for detecting low grade inflammation
DK2643470T3 (en) 2010-11-24 2016-05-17 Univ Yale Preparations and methods for treating ischemic injury with D-DT
JP5754685B2 (ja) * 2010-12-02 2015-07-29 国立研究開発法人農業・食品産業技術総合研究機構 基板上でビルドアップ型コンビナトリアルライブラリーを合成する方法
US20140017797A1 (en) 2010-12-13 2014-01-16 De Staadt der Nederlanden, vert doorde minister van VWS Protein affinity tag and uses thereof
KR20120066924A (ko) 2010-12-15 2012-06-25 제일모직주식회사 오르토-니트로벤질 에스테르 화합물 및 이를 포함하는 포지티브형 감광성 수지 조성물
WO2012083240A2 (en) 2010-12-16 2012-06-21 Dana-Farber Cancer Institute, Inc. Oligonucleotide array for tissue typing
JP2012131718A (ja) 2010-12-20 2012-07-12 Samsung Electronics Co Ltd 化合物合成方法、マイクロアレイ、酸転写用組成物及びバイオチップ製造用組成物
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
EP2474617A1 (en) 2011-01-11 2012-07-11 InteRNA Technologies BV Mir for treating neo-angiogenesis
EP2663656B1 (en) 2011-01-13 2016-08-24 Decode Genetics EHF Genetic variants as markers for use in urinary bladder cancer risk assessment
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US20120190021A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
AU2012214762B2 (en) 2011-02-07 2015-08-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP2673381A4 (en) 2011-02-07 2014-10-15 Univ Toronto BIOSONDES AND METHOD FOR THEIR USE
JP6020164B2 (ja) 2011-02-10 2016-11-02 三菱レイヨン株式会社 核酸の検出方法
EP3412778A1 (en) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
AU2012220540B2 (en) 2011-02-23 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
EP2678687B1 (en) 2011-02-24 2015-09-02 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a feline
CA2828532A1 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
US20120219950A1 (en) 2011-02-28 2012-08-30 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
CN107273712B (zh) 2011-03-02 2021-12-03 博格有限责任公司 基于细胞的探询式分析及其应用
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
SG193489A1 (en) 2011-03-18 2013-10-30 Eisai R&D Man Co Ltd Methods and compositions for predicting response to eribulin
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
JP2014510533A (ja) 2011-03-28 2014-05-01 ノバルティス アーゲー サイクリン依存性キナーゼ阻害剤に関連するマーカー
WO2012134813A1 (en) 2011-03-31 2012-10-04 St. Jude Children's Research Hospital Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
EP2694678A2 (en) 2011-04-04 2014-02-12 Netherland Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
US20140296248A1 (en) 2011-04-04 2014-10-02 Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis Methods and compositions for predicting resistance to anticancer treatment
EP3150750B1 (en) 2011-04-08 2018-12-26 Prognosys Biosciences, Inc. Peptide constructs and assay systems
US20140186340A1 (en) 2011-04-08 2014-07-03 Gilead Biologics, Inc. Methods and Compositions for Normalization of Tumor Vasculature by Inhibition of LOXL2
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2012142656A1 (en) 2011-04-18 2012-10-26 Garvan Institute Of Medical Research Method of diagnosing cancer
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
EP2527459A1 (en) 2011-05-02 2012-11-28 Rheinische Friedrich-Wilhelms-Universität Bonn Blood-based gene detection of non-small cell lung cancer
EP2520661A1 (en) 2011-05-02 2012-11-07 Rheinische Friedrich-Wilhelms-Universität Bonn Blood-based gene expression signatures in lung cancer
JP5951755B2 (ja) 2011-05-04 2016-07-13 エイチティージー モレキュラー ダイアグノスティクス, インコーポレイテッド 定量的ヌクレアーゼプロテクションアッセイ(qNPA)法および定量的ヌクレアーゼプロテクション配列決定(qNPS)法の改善
BR112013029163A2 (pt) 2011-05-17 2017-01-31 Plexxikon Inc modulação quinase e indicações dos mesmos
WO2012156515A1 (en) 2011-05-18 2012-11-22 Rheinische Friedrich-Wilhelms-Universität Bonn Molecular analysis of acute myeloid leukemia
WO2012159089A1 (en) 2011-05-19 2012-11-22 Sequenom, Inc. Products and processes for multiplex nucleic acid identification
EP2524967A1 (en) 2011-05-19 2012-11-21 Signature Diagnostics AG Methods and kits for diagnosing colorectal cancer
EP2524968A1 (en) 2011-05-19 2012-11-21 Signature Diagnostics AG Methods and kits for diagnosing colorectal cancer
CN103930563B (zh) 2011-06-01 2016-11-09 医学预后研究所 用于预测癌症复发的方法和装置
MX349011B (es) 2011-06-02 2017-07-05 Novartis Ag Biomarcadores para terapia de inhibidor de hedgehog.
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
CA2838086A1 (en) 2011-06-02 2012-12-06 Almac Diagnostics Limited Molecular diagnostic test for cancer
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
EP3444363B1 (en) 2011-06-03 2020-11-25 Eisai R&D Management Co., Ltd. Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
AU2012271487B2 (en) 2011-06-15 2017-05-25 Gen9, Inc. Methods for preparative in vitro cloning
RU2593952C2 (ru) 2011-06-15 2016-08-10 Хилл'С Пет Ньютришн, Инк. Композиции и способы для диагностики и мониторинга гипертиреоза у животных семейства кошачьих
JP2014518069A (ja) 2011-06-17 2014-07-28 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 骨髄異形成症候群対象の生存率を予測するための変異シグネチャー
EP2721181B1 (en) 2011-06-17 2019-12-18 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
EP2723901B1 (en) 2011-06-22 2018-08-08 Yale University Compositions and methods of diagnosing diseases and disorders associated with cell death
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
WO2013009705A2 (en) 2011-07-09 2013-01-17 The Trustees Of Columbia University In The City Of New York Biomarkers, methods, and compositions for inhibiting a multi-cancer mesenchymal transition mechanism
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
KR101545826B1 (ko) 2011-07-25 2015-08-19 씨에스아이알 어레이 프린팅
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US20130059296A1 (en) 2011-08-26 2013-03-07 Gen9, Inc. Compositions and Methods For High Fidelity Assembly of Nucleic Acids
US9435812B2 (en) 2011-08-31 2016-09-06 Ventana Medical Systems, Inc. Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
WO2013036290A1 (en) 2011-09-09 2013-03-14 Yale University Compositions and methods for assessing and treating inflammatory diseases and disorders
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US9920371B2 (en) 2011-09-22 2018-03-20 Medvet Sciences Pty. Ltd. Screening method
US20140238875A1 (en) 2011-09-26 2014-08-28 Toto Ltd. Method for specifically detecting test substance
EP3323897A1 (en) 2011-10-03 2018-05-23 Celmatix, Inc. Methods and devices for assessing risk to a putative offspring of developing a condition
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9566560B2 (en) 2011-10-06 2017-02-14 Illumina, Inc. Array domains having rotated patterns
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130090329A1 (en) 2011-10-07 2013-04-11 Suregene, Llc Methods and Compositions for the Treatment of Psychotic Disorders Through the Identification of the Olanzapine Poor Response Predictor Genetic Signature
US10221454B2 (en) 2011-10-10 2019-03-05 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2013056241A2 (en) 2011-10-14 2013-04-18 Pacific Biosciences Of California, Inc. Real-time redox sequencing
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
EP2768985B1 (en) 2011-10-21 2019-03-20 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
US20130142728A1 (en) 2011-10-27 2013-06-06 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
CA2862580A1 (en) 2011-10-28 2013-05-02 Millennium Pharmaceuticals, Inc. Biomarkers of response to nae inhibitors
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
US10100092B2 (en) 2011-11-03 2018-10-16 Vca, Inc. Compositions and methods to detect various infectious organisms
WO2013067451A2 (en) 2011-11-04 2013-05-10 Population Diagnostics Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
US9212381B2 (en) 2011-11-10 2015-12-15 President And Fellows Of Harvard College Methods and compositions for labeling polypeptides
CN104039328B (zh) 2011-11-11 2018-10-09 米伦纽姆医药公司 对蛋白酶体抑制剂的反应的生物标记
US20150184246A1 (en) 2011-11-11 2015-07-02 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
CA2856107C (en) 2011-11-18 2022-10-18 Memorial Sloan-Kettering Cancer Center 2-hydroxyglutarate as a biomarker for chronic hypoxia
DK3301177T3 (da) 2011-11-18 2020-06-15 Alnylam Pharmaceuticals Inc Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme
US10437858B2 (en) 2011-11-23 2019-10-08 23Andme, Inc. Database and data processing system for use with a network-based personal genetics services platform
KR102047569B1 (ko) * 2011-11-30 2019-11-21 소니 주식회사 케미컬 센서, 케미컬 센서 모듈, 화학물질 검출 장치 및 화학물질 검출 방법
EP2785874B1 (en) 2011-11-30 2018-09-26 Children's Hospital Medical Center Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support
US20140017174A1 (en) 2011-11-30 2014-01-16 Raja Atreya Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8748097B1 (en) 2011-12-02 2014-06-10 President And Fellows Of Harvard College Identification of agents for treating calcium disorders and uses thereof
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
CA2858581A1 (en) 2011-12-13 2013-06-20 Genomedx Biosciences, Inc. Cancer diagnostics using non-coding transcripts
WO2013095935A1 (en) 2011-12-19 2013-06-27 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating hyperthyroidism in companion animals
WO2013096528A1 (en) 2011-12-20 2013-06-27 Siemens Healthcare Diagnostics Inc. Coated substrates for high energy capture phase binding and methods of production and use thereof
AU2012358244A1 (en) 2011-12-21 2014-06-12 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
WO2013096819A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Macromolecule positioning by electrical potential
US9823246B2 (en) 2011-12-28 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
US9803231B2 (en) 2011-12-29 2017-10-31 Ibis Biosciences, Inc. Macromolecule delivery to nanowells
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
MX2018004950A (es) 2011-12-30 2022-01-24 Quest Diagnostics Invest Inc Aptámeros y métodos de diagnóstico para detectar el receptor de egf.
AU2013207778B2 (en) 2012-01-13 2017-10-12 Genentech, Inc. Biological markers for identifying patients for treatment with VEGF antagonists
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
LT2805280T (lt) 2012-01-20 2022-12-27 Sequenom, Inc. Diagnostikos būdai, kurie atsižvelgia į eksperimentines sąlygas
EP3418397B1 (en) 2012-01-24 2020-10-07 CD Diagnostics, Inc. System for detecting infection in synovial fluid
WO2013112923A1 (en) 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
US9135497B2 (en) 2012-01-27 2015-09-15 National Instruments Corporation Identifying randomly distributed microparticles in images to sequence a polynucleotide
EP2812344A4 (en) 2012-02-07 2015-10-28 Vibrant Holdings Llc SUBSTRATE, PEPTIDARRAYS AND METHOD
CA2863887C (en) 2012-02-09 2023-01-03 Population Diagnostics, Inc. Methods of screening low frequency gdna variation biomarkers for pervasive developmental disorder (pdd) or pervasive developmental disorder - not otherwise specified (pdd_nos)
CN104334196B (zh) 2012-02-16 2018-04-10 Atyr 医药公司 用于治疗自身免疫疾病和炎性疾病的组氨酰‑tRNA合成酶
WO2013123125A1 (en) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assembly of nucleic acid sequences in emulsions
EP2827882B1 (en) 2012-02-21 2020-04-08 Cytonics Corporation Systems, compositions, and methods for transplantation
SG11201404285VA (en) 2012-02-22 2014-10-30 Univ Pennsylvania Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
NZ628813A (en) 2012-02-23 2015-10-30 Univ Denmark Tech Dtu Methods for predicting anti-cancer response
WO2013124740A2 (en) 2012-02-23 2013-08-29 Stichting Vu-Vumc BRCA DEFICIENCY PROTEIN AND mRNA SIGNATURES USEFUL IN IDENTIFICATION OF PATIENTS WITH BRCA-DEFICIENT TUMORS AND PREDICTING BENEFIT OF ANTI-CANCER THERAPY IN CANCER PATIENTS
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
GB2513024B (en) 2012-02-27 2016-08-31 Cellular Res Inc A clonal amplification method
EP2820155B1 (en) 2012-02-28 2017-07-26 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
ES2930180T3 (es) 2012-03-02 2022-12-07 Sequenom Inc Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica
ES2662128T3 (es) 2012-03-05 2018-04-05 Adaptive Biotechnologies Corporation Determinación de cadenas de receptor inmunitario emparejadas a partir de la frecuencia de subunidades coincidentes
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013144202A1 (en) 2012-03-29 2013-10-03 Roche Diagnostics Gmbh Biomarkers for discriminating healthy and/or non-malignant neoplastic colorectal cells from colorectal cancer cells
CN104271157A (zh) 2012-03-30 2015-01-07 霍夫曼-拉罗奇有限公司 用于治疗癌症的诊断方法和组合物
BR112014024537A2 (pt) 2012-04-02 2017-08-08 Berg Llc métodos para identificar moduladores de um sistema biológico, de um processo de doença, e de angiogênese
EP2834371B1 (en) 2012-04-05 2019-01-09 The Regents of The University of California Gene expression panel for breast cancer prognosis
CA2871505C (en) 2012-04-24 2021-10-12 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
RU2014148779A (ru) 2012-05-04 2016-06-27 Новартис Аг Биомаркеры для терапии ингибитором iap
HUE029357T2 (en) 2012-05-08 2017-02-28 Adaptive Biotechnologies Corp Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
CA2872867C (en) 2012-05-11 2020-09-15 Clinical Genomics Pty Ltd Diagnostic gene marker panel for colorectal cancer
WO2013173844A1 (en) 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
ES2778028T3 (es) 2012-05-18 2020-08-07 Clinical Genomics Pty Ltd Un método de cribado para cáncer colorrectal
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
SG11201407595UA (en) 2012-05-21 2014-12-30 Univerisity Of California Generation of human ips cells by a synthetic self- replicative rna
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US9914967B2 (en) 2012-06-05 2018-03-13 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using DNA origami probes
CA3190075A1 (en) 2012-06-07 2013-12-12 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
WO2013188686A2 (en) 2012-06-15 2013-12-19 Wayne State University Biomarker test for prediction or early detection of preeclampsia and/or hellp syndrome
HUE065221T2 (hu) 2012-06-15 2024-05-28 Genesis Theranostix Korlatolt Feleloessegue Tarsasag Biomarker teszt praeeclampsia elõrejelzésére vagy korai kimutatására
EP2861787B1 (en) 2012-06-18 2017-09-20 Nugen Technologies, Inc. Compositions and methods for negative selection of non-desired nucleic acid sequences
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150191719A1 (en) 2012-06-25 2015-07-09 Gen9, Inc. Methods for Nucleic Acid Assembly and High Throughput Sequencing
EP2870263A1 (en) 2012-07-03 2015-05-13 InteRNA Technologies B.V. Diagnostic portfolio and its uses
EP3309263B1 (en) 2012-07-09 2019-12-25 Novartis AG Biomarkers associated with cdk inhibitors
WO2014009245A2 (en) 2012-07-09 2014-01-16 Qithera Gmbh Novel drug target indentification methods
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2875458A2 (en) 2012-07-19 2015-05-27 President and Fellows of Harvard College Methods of storing information using nucleic acids
WO2014015217A1 (en) 2012-07-19 2014-01-23 Vertex Pharmaceuticals Incorporated Biomarkers for hcv infected patients
CN104583421A (zh) 2012-07-19 2015-04-29 阿瑞奥萨诊断公司 遗传变体的基于多重的顺序连接的检测
AU2013293049A1 (en) 2012-07-20 2015-02-26 La Trobe University Method of diagnosis and treatment
EP2877494B1 (en) 2012-07-23 2020-07-15 La Jolla Institute for Allergy and Immunology Ptprs and proteoglycans in autoimmune disease
KR20180088926A (ko) 2012-07-24 2018-08-07 파마싸이클릭스 엘엘씨 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
KR20150038241A (ko) 2012-07-27 2015-04-08 노파르티스 아게 Jak/stat 억제제에 대한 치료 반응의 예측
CN104520714A (zh) 2012-07-31 2015-04-15 诺华股份有限公司 与对人双微体2(mdm2)抑制剂的敏感性相关的标志物
DK3435084T3 (da) 2012-08-16 2023-05-30 Mayo Found Medical Education & Res Prostatakræftprognose under anvendelse af biomarkører
AU2013306373B2 (en) 2012-08-20 2017-09-07 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
EP2893040B1 (en) 2012-09-04 2019-01-02 Guardant Health, Inc. Methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
US9976180B2 (en) 2012-09-14 2018-05-22 Population Bio, Inc. Methods for detecting a genetic variation in subjects with parkinsonism
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
US10233495B2 (en) 2012-09-27 2019-03-19 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
CA3088591C (en) 2012-09-28 2023-01-03 Vibrant Holdings, Llc Inverted pillar plates for assaying microarrays and methods of using same.
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
CN104822844B (zh) 2012-10-01 2019-05-07 米伦纽姆医药公司 预测对抑制剂的反应的生物标记物和方法以及其用途
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US10162800B2 (en) 2012-10-17 2018-12-25 Celmatix Inc. Systems and methods for determining the probability of a pregnancy at a selected point in time
US9177098B2 (en) 2012-10-17 2015-11-03 Celmatix Inc. Systems and methods for determining the probability of a pregnancy at a selected point in time
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
US20150354006A1 (en) 2012-10-19 2015-12-10 Novartis Ag Markers for acute lymphoblastic leukemia
EP2722105A1 (en) 2012-10-22 2014-04-23 Universität Wien Method of in situ synthesizing microarrays
EP2917715B1 (en) 2012-11-06 2019-04-03 Biodot, Inc. Controlled printing of a cell sample for karyotyping
WO2014074942A1 (en) 2012-11-08 2014-05-15 Illumina, Inc. Risk variants of alzheimer's disease
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
CA2891651C (en) 2012-11-14 2019-01-22 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
WO2014078652A1 (en) 2012-11-16 2014-05-22 Zs Genetics, Inc. Heavy atom labeled nucleosides, nucleotides, and nucleic acid polymers, and uses thereof
GB201220924D0 (en) 2012-11-21 2013-01-02 Cancer Res Inst Royal Materials and methods for determining susceptibility or predisposition to cancer
NZ709167A (en) 2012-11-27 2020-03-27 Univ Pontificia Catolica Chile Compositions and methods for diagnosing thyroid tumors
ES2651347T3 (es) 2012-11-28 2018-01-25 Merck Sharp & Dohme Corp. Composiciones y métodos para el tratamiento del cáncer
CA2891542C (en) 2012-11-30 2021-12-14 Accelerated Biosciences Corp. Pancreatic progenitor cells expressing betatrophin and insulin
WO2014087156A1 (en) 2012-12-03 2014-06-12 Almac Diagnostics Limited Molecular diagnostic test for cancer
BR112015013105B1 (pt) 2012-12-05 2022-02-08 Alnylam Pharmaceuticals, Inc Agente de rnai de fita dupla capaz de inibir a expressão de pcsk9, seus usos, composição farmacêutica e método de inibição da expressão de pcsk9 em uma célula in vitro
US8993233B2 (en) 2012-12-12 2015-03-31 The Broad Institute Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
DK2921557T3 (en) 2012-12-12 2016-11-07 Broad Inst Inc Design of systems, methods and optimized sequence manipulation guide compositions
EP2931892B1 (en) 2012-12-12 2018-09-12 The Broad Institute, Inc. Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
AU2013359212B2 (en) 2012-12-12 2017-01-19 Massachusetts Institute Of Technology Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
ES2658401T3 (es) 2012-12-12 2018-03-09 The Broad Institute, Inc. Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas
EP2931899A1 (en) 2012-12-12 2015-10-21 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
US9836577B2 (en) 2012-12-14 2017-12-05 Celmatix, Inc. Methods and devices for assessing risk of female infertility
WO2014100626A1 (en) 2012-12-21 2014-06-26 Hutman Diagnostics AG Microarrays
MX2015004979A (es) 2012-12-21 2015-07-17 Eisai R&D Man Co Ltd Forma amorfa de derivado de quinolina y metodo para su produccion.
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP4414990A2 (en) 2013-01-17 2024-08-14 Personalis, Inc. Methods and systems for genetic analysis
US20140206841A1 (en) * 2013-01-18 2014-07-24 Protein Technologies, Inc. Peptide Synthesis Apparatus and Methods Using Infrared Energy
TW201514310A (zh) 2013-01-21 2015-04-16 Abbvie Inc 發炎性疾病之抗-tnf與抗-il17組合療法生物標記
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
EP3885446A1 (en) 2013-02-01 2021-09-29 The Regents of The University of California Methods for genome assembly and haplotype phasing
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
JP2016514091A (ja) 2013-02-08 2016-05-19 ミスフォールディング ダイアグノスティクス, インコーポレイテッド トランスサイレチン抗体およびその使用
KR102398430B1 (ko) 2013-02-14 2022-05-13 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 간질 폐렴의 위험을 예측하는 방법
WO2014127328A2 (en) 2013-02-15 2014-08-21 Vibrant Holdings, Llc. Methods and compositions for amplified electrochemiluminescence detection
WO2014130923A2 (en) 2013-02-25 2014-08-28 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
US9267171B2 (en) 2013-02-28 2016-02-23 New York University DNA photolithography with cinnamate crosslinkers
EP2962100B1 (en) 2013-02-28 2021-07-28 Caprion Proteomics Inc. Tuberculosis biomarkers and uses thereof
CN105378477B9 (zh) 2013-03-11 2021-08-06 梅索磅秤技术有限公司 用于进行多路测定法的改进方法
TWI582239B (zh) 2013-03-11 2017-05-11 諾華公司 與wnt抑制劑相關之標記
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
WO2014159242A1 (en) 2013-03-14 2014-10-02 Novartis Ag Notch 3 mutants and uses thereof
EA201591707A1 (ru) 2013-03-14 2016-03-31 Элнилэм Фармасьютикалз, Инк. КОМПОЗИЦИИ иРНК КОМПОНЕНТА КОМПЛЕМЕНТА C5 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US10308986B2 (en) 2013-03-14 2019-06-04 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
CN105246916A (zh) 2013-03-14 2016-01-13 诺华股份有限公司 针对notch 3的抗体
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
EP2971130A4 (en) 2013-03-15 2016-10-05 Nugen Technologies Inc SEQUENTIAL SEQUENCING
GB2584364A (en) 2013-03-15 2020-12-02 Abvitro Llc Single cell bar-coding for antibody discovery
EP3366785A3 (en) 2013-03-15 2018-09-19 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
EP2972279B1 (en) 2013-03-15 2021-10-06 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
US10535420B2 (en) 2013-03-15 2020-01-14 Affymetrix, Inc. Systems and methods for probe design to detect the presence of simple and complex indels
CN105051525B (zh) 2013-03-15 2019-07-26 生命科技公司 具有薄导电元件的化学设备
US9944992B2 (en) 2013-03-15 2018-04-17 The University Of Chicago Methods and compositions related to T-cell activity
US10006919B2 (en) 2013-03-15 2018-06-26 Arizona Board Of Regents On Behalf Of Arizona State University Peptide array quality control
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
WO2014144383A1 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Non-covalent patterned chemical features and use thereof in maldi-based quality control
US20140274749A1 (en) 2013-03-15 2014-09-18 Affymetrix, Inc. Systems and Methods for SNP Characterization and Identifying off Target Variants
EP2971132B1 (en) 2013-03-15 2020-05-06 Baylor Research Institute Tissue and blood-based mirna biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
ES2751402T3 (es) 2013-03-27 2020-03-31 Bluegnome Ltd Evaluación del riesgo de aneuploidía
LT2981921T (lt) 2013-04-03 2023-02-27 Sequenom, Inc. Neinvazinio genetinių variacijų vertinimo būdai ir procesai
WO2014169928A1 (de) * 2013-04-17 2014-10-23 Karlsruher Institut für Technologie Verfahren zur kombinatorischen partikelmanipulation zur herstellung von hochdichten molekülarrays, insbesondere von peptidarrays, und damit erhältliche molekülarrays
US20160091485A1 (en) 2013-04-25 2016-03-31 The Broad Institute, Inc. Markers for ezh2 inhibitors
RU2015150233A (ru) 2013-05-01 2017-06-02 Файв Прайм Терапьютикс, Инк. Способы лечения злокачественной опухоли
CN105378113B (zh) 2013-05-06 2020-02-21 加利福尼亚太平洋生物科学股份有限公司 实时电子测序
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
ES2687968T3 (es) 2013-05-14 2018-10-30 Eisai R&D Management Co., Ltd. Biomarcadores para pronosticar y evaluar la reactividad de sujetos con cáncer de endometrio a compuestos con lenvatinib
EP3000897B1 (en) 2013-05-21 2019-10-16 Biomérieux Colorectal cancer prognosis agent kit
KR102486617B1 (ko) 2013-05-22 2023-01-12 알닐람 파마슈티칼스 인코포레이티드 Tmprss6 조성물 및 이의 사용 방법
PT2999785T (pt) 2013-05-22 2018-07-09 Alnylam Pharmaceuticals Inc Composições de irna de serpina1 e métodos de uso das mesmas
WO2014190147A2 (en) 2013-05-23 2014-11-27 Five Prime Therapeutics, Inc. Methods of treating cancer
IL309903A (en) 2013-05-24 2024-03-01 Sequenom Inc Methods and processes for non-invasive evaluation of genetic variations
WO2014195032A1 (en) 2013-06-07 2014-12-11 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
EP3008229B1 (en) 2013-06-10 2020-05-27 President and Fellows of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
ES2971972T3 (es) 2013-06-13 2024-06-10 Hoffmann La Roche Análisis estadístico para la determinación no invasiva de aneuploidía del cromosoma Y
CN105308073B (zh) 2013-06-14 2019-08-13 加利福尼亚太平洋生物科学股份有限公司 双生物素化标签
US10544449B2 (en) 2013-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Bis-biotinylation tags
DK3011032T3 (da) 2013-06-17 2020-01-20 Broad Inst Inc Fremføring, modificering og optimering af systemer, fremgangsmåder og sammensætninger til målretning mod og modellering af sygdomme og forstyrrelser i postmitotiske celler
WO2014204729A1 (en) 2013-06-17 2014-12-24 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
CN106062197A (zh) 2013-06-17 2016-10-26 布罗德研究所有限公司 用于序列操纵的串联指导系统、方法和组合物的递送、工程化和优化
RU2716420C2 (ru) 2013-06-17 2020-03-11 Те Брод Инститьют Инк. Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
AU2014281027A1 (en) 2013-06-17 2016-01-28 Massachusetts Institute Of Technology Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
KR102299305B1 (ko) 2013-06-21 2021-09-06 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
US9708657B2 (en) * 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
US9404922B2 (en) 2013-07-15 2016-08-02 The Rockefeller University Recombinant phages and proteins
TWI646230B (zh) 2013-08-05 2019-01-01 扭轉生物科技有限公司 重新合成之基因庫
MX2016001854A (es) 2013-08-12 2016-09-06 Genentech Inc Composiciones y metodo para tratar condiciones asociadas con el complemento.
GB201314721D0 (en) * 2013-08-16 2013-10-02 Almagen Ltd A method of selectively masking one or more sites on a surface and a method of synthesising an array of molecules
US9683937B2 (en) * 2013-08-23 2017-06-20 Semiconductor Components Industries, Llc Imaging devices for molecule detection
GB2525104B (en) 2013-08-28 2016-09-28 Cellular Res Inc Massively Parallel Single Cell Nucleic Acid Analysis
WO2015031654A2 (en) 2013-08-28 2015-03-05 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
US11136625B2 (en) 2013-08-28 2021-10-05 Crown Bioscience, Inc. (Taicang) Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
WO2015031689A1 (en) 2013-08-30 2015-03-05 Personalis, Inc. Methods and systems for genomic analysis
SG10201914005TA (en) 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
WO2015042564A1 (en) 2013-09-23 2015-03-26 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing transthyretin (ttr) associated diseases
EP3543353A1 (en) 2013-09-23 2019-09-25 The University of Chicago Methods and compositions relating to cancer therapy with dna damaging agents
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
US9937126B2 (en) 2013-10-02 2018-04-10 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods for purification
EP3052193B1 (en) 2013-10-03 2018-01-31 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
BR112016007401B1 (pt) 2013-10-04 2023-04-11 Sequenom, Inc. Método para determinar a presença ou ausência de uma aneuploidia cromossômica em uma amostra
JP2017504307A (ja) 2013-10-07 2017-02-09 セルラー リサーチ, インコーポレイテッド アレイ上のフィーチャーをデジタルカウントするための方法およびシステム
CA2925111C (en) 2013-10-07 2024-01-16 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
WO2015058052A1 (en) 2013-10-18 2015-04-23 The Broad Institute Inc. Spatial and cellular mapping of biomolecules in situ by high-throughput sequencing
KR20160068802A (ko) 2013-10-23 2016-06-15 제넨테크, 인크. 호산구성 장애를 진단 및 치료하는 방법
US20160265036A1 (en) 2013-11-05 2016-09-15 Htg Molecular Diagnostics, Inc. Methods for detecting nucleic acids
EP3066215B1 (en) 2013-11-06 2019-04-24 The United States of America, represented by the Secretary, Department of Health and Human Services Method for subtyping lymphoma types by means of expression profiling
FI3511422T3 (fi) 2013-11-12 2023-01-31 Menetelmiä ja koostumuksia endometriooosin diagnosointia, ennustamista ja hoitoa varten
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ, インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
US11149316B2 (en) 2013-12-09 2021-10-19 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors
WO2015089368A2 (en) 2013-12-12 2015-06-18 Alnylam Pharmaceuticals, Inc. Complement component irna compositions and methods of use thereof
EP3079726B1 (en) 2013-12-12 2018-12-05 The Broad Institute, Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3084003A4 (en) 2013-12-17 2017-07-19 Merck Sharp & Dohme Corp. Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists
EP3825419A3 (en) 2013-12-20 2021-09-15 Université de Lausanne Diagnostic, prognostic and therapeutic uses of long noncoding rnas for heart disease and regenerative medicine
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
JP6571665B2 (ja) 2013-12-28 2019-09-04 ガーダント ヘルス, インコーポレイテッド 遺伝的バリアントを検出するための方法およびシステム
EP3090061A2 (en) 2013-12-31 2016-11-09 F. Hoffmann-La Roche AG Methods of assessing epigenetic regulation of genome function via dna methylation status and systems and kits therefor
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
AU2015206336B2 (en) 2014-01-16 2020-01-23 Illumina, Inc. Gene expression panel for prognosis of prostate cancer recurrence
US10850278B2 (en) 2014-01-29 2020-12-01 Arizona Board Of Regents On Behalf Of Arizona State University Microreactor array platform
US20170073754A1 (en) 2014-02-07 2017-03-16 Novartis Ag Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
CA2938731A1 (en) 2014-02-08 2015-08-13 Genentech, Inc. Methods of treating alzheimer's disease
WO2015127242A1 (en) 2014-02-21 2015-08-27 President And Fellows Of Harvard College De novo design of allosteric proteins
WO2015127409A1 (en) 2014-02-21 2015-08-27 Vibrant Holdings, Llc Selective photo activation of amino acids for single step peptide coupling
CA2940422A1 (en) 2014-02-24 2015-08-27 Children's Hospital Medical Center Methods and compositions for personalized pain management
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
ES2741740T3 (es) 2014-03-05 2020-02-12 Adaptive Biotechnologies Corp Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9885086B2 (en) 2014-03-20 2018-02-06 Pharmacyclics Llc Phospholipase C gamma 2 and resistance associated mutations
WO2015148919A2 (en) 2014-03-27 2015-10-01 Yale University Circulating micrornas as biomarkers for endometriosis
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3132059B1 (en) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
AU2015255752B2 (en) 2014-05-08 2020-07-23 Immunoforge Co., Ltd. Methods and compositions for treating Cystic Fibrosis
KR102246800B1 (ko) 2014-05-13 2021-04-30 바이오아트라, 인코퍼레이티드 조건부 활성 생체 단백질
JP2017516501A (ja) 2014-05-30 2017-06-22 ジーンセントリック ダイアグノスティクス, インコーポレイテッド 肺がんのタイピング法
US20160000936A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
EP3351642B1 (en) 2014-06-13 2019-09-11 Q-Linea AB Method for detecting and characterising a microorganism
JP2017523776A (ja) 2014-07-14 2017-08-24 ジェネンテック, インコーポレイテッド 膠芽腫の診断方法及びその治療用組成物
CA2954764A1 (en) 2014-07-15 2016-01-21 Ontario Institute For Cancer Research Methods and devices for predicting anthracycline treatment efficacy
CA2954895A1 (en) 2014-07-17 2016-01-21 Celmatix Inc. Methods and systems for assessing infertility and related pathologies
EP3760739A1 (en) 2014-07-30 2021-01-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2015296029B2 (en) 2014-08-01 2022-01-27 Dovetail Genomics, Llc Tagging nucleic acids for sequence assembly
CA2957549C (en) 2014-08-08 2022-07-26 Children's Hospital Medical Center Diagnostic method for distinguishing forms of esophageal eosinophilia
US10093967B2 (en) 2014-08-12 2018-10-09 The Regents Of The University Of Michigan Detection of nucleic acids
US20180363070A9 (en) 2014-08-12 2018-12-20 Univ Wayne State Systems and methods to detect stem cell stress and uses thereof
DK3180447T3 (da) 2014-08-15 2020-06-15 Myriad Genetics Inc Fremgangsmåder og materialer til analyse af homolog rekombinationsdeficiens
ES2780904T3 (es) 2014-08-17 2020-08-27 Broad Inst Inc Edición genómica usando nickasas Cas9
ES2913865T3 (es) 2014-08-28 2022-06-06 Bioatla Inc Receptores de antígeno quimérico condicionalmente activos para células T modificadas
BR112017002827B1 (pt) 2014-08-28 2023-04-18 Eisai R&D Management Co., Ltd Derivado de quinolina altamente puro e método para produção do mesmo
EP3453396A1 (en) 2014-08-28 2019-03-13 Yale University Compositions and methods for treating an inflammatory disease or disorder
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
EP3189152A4 (en) 2014-09-03 2018-04-04 BioAtla LLC Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts
CA2996445A1 (en) 2014-09-05 2016-03-10 Eli Hatchwell Methods and compositions for inhibiting and treating neurological conditions
US20180010132A1 (en) 2014-09-11 2018-01-11 Novartis Ag Inhibition of prmt5 to treat mtap-deficiency-related diseases
EP3191591A1 (en) 2014-09-12 2017-07-19 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting complement component c5 and methods of use thereof
SG11201702060VA (en) 2014-09-15 2017-04-27 Abvitro Inc High-throughput nucleotide library sequencing
EP3194624B1 (en) 2014-09-15 2022-02-16 Garvan Institute of Medical Research Methods for diagnosis, prognosis and monitoring of breast cancer and reagents therefor
DK3198035T3 (da) 2014-09-26 2023-01-30 Allarity Therapeutics Europe ApS Fremgangsmåder til forudsigelse af medicinrespons
WO2016054483A1 (en) 2014-10-03 2016-04-07 Novartis Ag Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
JOP20200115A1 (ar) 2014-10-10 2017-06-16 Alnylam Pharmaceuticals Inc تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
WO2016061487A1 (en) 2014-10-17 2016-04-21 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
US10392663B2 (en) 2014-10-29 2019-08-27 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples
WO2016069694A2 (en) 2014-10-30 2016-05-06 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
EP4026913A1 (en) 2014-10-30 2022-07-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
CN107206043A (zh) 2014-11-05 2017-09-26 维拉赛特股份有限公司 使用机器学习和高维转录数据在经支气管活检上诊断特发性肺纤维化的系统和方法
US20160146799A1 (en) 2014-11-05 2016-05-26 Nirmidas Biotech, Inc. Metal composites for enhanced imaging
US11708608B2 (en) 2014-11-10 2023-07-25 Genentech, Inc. Therapeutic and diagnostic methods for IL-33-mediated disorders
JP2017533733A (ja) 2014-11-11 2017-11-16 アボツト・モレキユラー・インコーポレイテツド ハイブリダイゼーションプローブおよび方法
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
SG11201704291QA (en) 2014-11-26 2017-06-29 Accelerated Biosciences Corp Induced hepatocytes and uses thereof
EP3227446A1 (en) 2014-12-01 2017-10-11 Novartis AG Compositions and methods for diagnosis and treatment of prostate cancer
WO2016090174A1 (en) 2014-12-03 2016-06-09 Auckland Uniservices, Ltd. Kinase inhibitor prodrug for the treatment of cancer
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
SG10202012249YA (en) 2014-12-08 2021-01-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
KR20170086661A (ko) 2014-12-09 2017-07-26 머크 샤프 앤드 돔 코포레이션 Pd-1 길항제에 대한 반응의 유전자 시그너처 바이오마커를 유도하기 위한 시스템 및 방법
EP3230452A1 (en) 2014-12-12 2017-10-18 The Broad Institute Inc. Dead guides for crispr transcription factors
WO2016094867A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Protected guide rnas (pgrnas)
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
TWI832669B (zh) 2014-12-18 2024-02-11 美商生命技術公司 具有傳輸器組態的高資料速率積體電路
US10379079B2 (en) 2014-12-18 2019-08-13 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
AU2015369725A1 (en) 2014-12-24 2017-06-29 Massachusetts Institute Of Technology CRISPR having or associated with destabilization domains
JP6900314B2 (ja) 2014-12-24 2021-07-07 ジェネンテック, インコーポレイテッド 膀胱癌の治療、診断、及び予後判定方法
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
WO2016123125A1 (en) 2015-01-27 2016-08-04 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
WO2016123454A1 (en) 2015-01-29 2016-08-04 Board Of Trustees Of Miching State University Cryptic polypeptides and uses thereof
WO2016126987A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US10688156B2 (en) 2015-02-09 2020-06-23 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
WO2016130572A2 (en) 2015-02-10 2016-08-18 Dana-Farber Cancer Institute, Inc. Methods of determining levels of exposure to radiation and uses thereof
AU2016219263B2 (en) 2015-02-13 2022-12-01 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
US11434264B2 (en) 2015-02-13 2022-09-06 Quanterix Corporation Immunoassays for differential detection of clostridium difficile
CN107533590B (zh) 2015-02-17 2021-10-26 多弗泰尔基因组学有限责任公司 核酸序列装配
EP3259371B1 (en) 2015-02-19 2020-09-02 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
ES2904997T3 (es) 2015-02-24 2022-04-06 Hope City Plataformas de cribado de bibliotecas abordadas espacialmente codificadas químicamente
WO2016138122A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
WO2016138071A1 (en) 2015-02-24 2016-09-01 Short Jay M Conditionally active biological proteins
MX2017010474A (es) 2015-02-25 2017-11-28 Eisai R&D Man Co Ltd Metodo para suprimir el amargor de un derivado de quinoleina.
WO2016138496A1 (en) 2015-02-27 2016-09-01 Cellular Research, Inc. Spatially addressable molecular barcoding
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
US20180106795A1 (en) 2015-03-12 2018-04-19 Vibrant Holdings, Llc Polypeptide arrays and methods of attaching polypeptides to an array
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
CA3077811C (en) 2015-03-24 2024-02-27 Illumina, Inc. Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
US11807896B2 (en) 2015-03-26 2023-11-07 Dovetail Genomics, Llc Physical linkage preservation in DNA storage
WO2016161022A2 (en) 2015-03-30 2016-10-06 Accerlate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US11535882B2 (en) 2015-03-30 2022-12-27 Becton, Dickinson And Company Methods and compositions for combinatorial barcoding
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US11326211B2 (en) 2015-04-17 2022-05-10 Merck Sharp & Dohme Corp. Blood-based biomarkers of tumor sensitivity to PD-1 antagonists
JP2018513166A (ja) 2015-04-20 2018-05-24 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 系統的な探索、成熟化および伸長プロセスにより同定した、タンパク質に対する特異的ペプチドバインダー
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
US10233489B2 (en) 2015-04-24 2019-03-19 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
GB201507026D0 (en) 2015-04-24 2015-06-10 Linea Ab Q Medical sample transportation container
EP3286328B1 (en) 2015-04-24 2020-10-21 Agena Bioscience, Inc. Multiplex methods for detection and quantification of minor variants
EP3289106A4 (en) 2015-05-01 2019-03-20 Griffith University DIAGNOSTIC METHODS
CA2984589A1 (en) 2015-05-01 2016-11-10 The University Of British Columbia Biomarkers for the detection of acute rejection in heart transplantation
US10900975B2 (en) 2015-05-12 2021-01-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods of epitope binning and antibody profiling
CA2987397C (en) 2015-05-29 2022-03-01 Illumina, Inc. Sample carrier and assay system for conducting designated reactions
WO2016196065A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Methods and compositions for assessing responsiveness of cancers to bet inhibitors
US11124823B2 (en) 2015-06-01 2021-09-21 Becton, Dickinson And Company Methods for RNA quantification
WO2016201301A1 (en) 2015-06-12 2016-12-15 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
SG11201710198YA (en) 2015-06-16 2018-01-30 Eisai R&D Man Co Ltd Anticancer agent
WO2016205749A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2016205323A1 (en) 2015-06-18 2016-12-22 Alnylam Pharmaceuticals, Inc. Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
FI3430134T3 (fi) 2015-06-18 2023-01-13 Uusia CRISPR-entsyymejä ja järjestelmiä
WO2017011286A1 (en) 2015-07-10 2017-01-19 Alnylam Pharmaceuticals, Inc. Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
US11169150B2 (en) 2015-07-20 2021-11-09 Sentilus Holdco LLC Chips, detectors, and methods of making and using the same
GB201512869D0 (en) 2015-07-21 2015-09-02 Almac Diagnostics Ltd Gene signature for minute therapies
KR101844048B1 (ko) 2015-07-22 2018-03-30 주식회사 스몰머신즈 분자 고정화 패턴 및 그를 형성하는 방법
WO2017019804A2 (en) 2015-07-28 2017-02-02 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
EP3328440A4 (en) 2015-07-28 2019-01-16 Otonomy, Inc. TREATMENT USING TRK B TRK B TRK ANTAGONISTS
EP3124619B1 (en) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagents, method and kit for across and within dog breed glaucoma diagnosis
CA2994416A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
WO2017024049A1 (en) 2015-08-06 2017-02-09 Pacific Biosciences Of California, Inc. Single-molecule nanofet sequencing systems and methods
CN106446605B (zh) * 2015-08-13 2021-07-20 生捷科技控股公司 产生聚合物阵列的方法
EP3130681B1 (en) 2015-08-13 2019-11-13 Centrillion Technology Holdings Corporation Methods for synchronizing nucleic acid molecules
CN108474805A (zh) 2015-08-24 2018-08-31 亿明达股份有限公司 用于生物和化学测定的线路内蓄压器和流量控制系统
CA2995995A1 (en) 2015-08-24 2017-03-02 Halo-Bio Rnai Therapeutics, Inc. Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
KR20180051550A (ko) 2015-09-02 2018-05-16 알닐람 파마슈티칼스 인코포레이티드 프로그램된 세포사 1 리간드 1 (PD-L1) iRNA 조성물 및 그의 사용 방법
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3347465B1 (en) 2015-09-11 2019-06-26 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
EP3141613A1 (en) 2015-09-11 2017-03-15 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Detection of quality of surface water
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
JP6982362B2 (ja) 2015-09-18 2021-12-17 ツイスト バイオサイエンス コーポレーション オリゴ核酸変異体ライブラリーとその合成
CN113604546A (zh) 2015-09-22 2021-11-05 特韦斯特生物科学公司 用于核酸合成的柔性基底
US11156611B2 (en) 2015-09-24 2021-10-26 Abvitro Llc Single cell characterization using affinity-oligonucleotide conjugates and vessel barcoded polynucleotides
WO2017050872A1 (en) 2015-09-25 2017-03-30 F. Hoffmann-La Roche Ag Transamidation employing sortase a in deep eutectic solvents
CN108138204B (zh) 2015-09-25 2021-12-31 豪夫迈·罗氏有限公司 使用分选酶a生产硫酯的方法
WO2017053902A1 (en) 2015-09-25 2017-03-30 Abvitro Llc High throughput process for t cell receptor target identification of natively-paired t cell receptor sequences
CN108138158B (zh) 2015-09-25 2021-11-09 豪夫迈·罗氏有限公司 可溶性分选酶a
US11384399B2 (en) 2015-09-29 2022-07-12 Htg Molecular Diagnostics, Inc. Methods for subtyping diffuse large B-cell lymphoma (DLBCL)
CN108513586A (zh) 2015-09-30 2018-09-07 因姆内克斯普雷斯私人有限公司 病原体生物标志物及其用途
US12048753B2 (en) 2015-10-01 2024-07-30 Whitehead Institute For Biomedical Research Labeling of antibodies
US10829787B2 (en) 2015-10-14 2020-11-10 Life Technologies Corporation Ribonucleoprotein transfection agents
EP3362580B1 (en) 2015-10-18 2021-02-17 Affymetrix, Inc. Multiallelic genotyping of single nucleotide polymorphisms and indels
CN108368542B (zh) 2015-10-19 2022-04-08 多弗泰尔基因组学有限责任公司 用于基因组组装、单元型定相以及独立于靶标的核酸检测的方法
KR20180066236A (ko) 2015-10-22 2018-06-18 조운스 테라퓨틱스, 인크. Icos 발현을 계측하기 위한 유전자 특질
WO2017070605A1 (en) 2015-10-22 2017-04-27 The Broad Institute Inc. Type vi-b crispr enzymes and systems
US10427126B2 (en) 2015-10-28 2019-10-01 Roche Sequencing Solutions, Inc. System and method for longitudinal analysis of peptide synthesis
WO2017075294A1 (en) 2015-10-28 2017-05-04 The Board Institute Inc. Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
US11996168B2 (en) 2015-10-28 2024-05-28 The Broad Institute, Inc. Systems and methods for determining relative abundances of biomolecules
DK3377654T3 (da) 2015-11-16 2024-02-19 Revere Biosensors Llc Systemer og fremgangsmåder til identificering af og skelnen mellem genetiske prøver
US10731211B2 (en) 2015-11-18 2020-08-04 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
EP3384041B1 (en) 2015-11-30 2021-01-20 H. Hoffnabb-La Roche Ag Method for identification of protease substrates
CN108603307A (zh) 2015-12-01 2018-09-28 特韦斯特生物科学公司 功能化表面及其制备
BR112018011475A2 (pt) 2015-12-07 2018-12-04 Plexxikon Inc compostos e métodos para modulação de quinase e indicação para a mesma
WO2017100454A1 (en) 2015-12-09 2017-06-15 Intuitive Biosciences, Inc. Automated silver enhancement system
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US20190233814A1 (en) 2015-12-18 2019-08-01 The Broad Institute, Inc. Novel crispr enzymes and systems
AU2016377391B2 (en) 2015-12-24 2022-09-01 Immunexpress Pty Ltd Triage biomarkers and uses therefor
EP4059570A1 (en) 2016-01-13 2022-09-21 Children's Hospital Medical Center Compositions and methods for treating allergic inflammatory conditions
US10519442B2 (en) 2016-02-11 2019-12-31 City Of Hope Twist signaling inhibitor compositions and methods of using the same
US10184939B2 (en) 2016-02-12 2019-01-22 Roche Sequencing Solutions, Inc. Detection of neoantigens using peptide arrays
US10975417B2 (en) 2016-02-23 2021-04-13 Dovetail Genomics, Llc Generation of phased read-sets for genome assembly and haplotype phasing
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
EP3433262A4 (en) 2016-03-25 2019-11-20 Muralidhar Reddy Moola COMBINATORY SYNTHESIS AND DEVELOPMENT OF BIOMARKERS
WO2017167712A1 (en) 2016-03-30 2017-10-05 F. Hoffmann-La Roche Ag Improved sortase
US11845938B2 (en) 2016-03-31 2023-12-19 City Of Hope Aptamer compositions and the use thereof
CN109313184A (zh) * 2016-04-01 2019-02-05 健康之语公司 用于治疗性抗体表征的基于阵列的肽文库
WO2017176652A2 (en) 2016-04-04 2017-10-12 Sinopia Biosciences, Inc. Treating extrapyramidal syndrome using trapidil
MA45295A (fr) 2016-04-19 2019-02-27 Alnylam Pharmaceuticals Inc Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
EP3445856A1 (en) 2016-04-19 2019-02-27 The Broad Institute Inc. Novel crispr enzymes and systems
WO2017184768A1 (en) 2016-04-19 2017-10-26 The Broad Institute Inc. Novel crispr enzymes and systems
EP3445853A1 (en) 2016-04-19 2019-02-27 The Broad Institute, Inc. Cpf1 complexes with reduced indel activity
ES2859423T3 (es) 2016-04-20 2021-10-04 Us Health Evaluación del linfoma de células del manto y procedimientos relacionados con el mismo
US20190128895A1 (en) 2016-04-20 2019-05-02 Ldx Prognostics Limited Co. Methods and compositions for prognosing preterm birth
GB2554767A (en) 2016-04-21 2018-04-11 Q Linea Ab Detecting and characterising a microorganism
EP3452614B1 (en) 2016-05-02 2023-06-28 Becton, Dickinson and Company Accurate molecular barcoding
HRP20221298T1 (hr) 2016-05-13 2022-12-23 Bioatla, Inc. Anti-ror2 protutijela, fragmenti protutijela, njihovi imunokonjugati i njihove uporabe
SG11201810088SA (en) 2016-05-13 2018-12-28 Dovetail Genomics Llc Recovering long-range linkage information from preserved samples
CN109196362A (zh) 2016-05-17 2019-01-11 苏州爱尔迪思生物科技有限公司 用于提供子痫前期评估的方法和组合物
CN109790583B (zh) 2016-05-17 2023-08-25 基因中心治疗公司 对肺腺癌亚型分型的方法
WO2017201164A1 (en) 2016-05-17 2017-11-23 Genecentric Diagnostics, Inc. Methods for subtyping of lung squamous cell carcinoma
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
WO2017205691A1 (en) 2016-05-26 2017-11-30 Cellular Research, Inc. Molecular label counting adjustment methods
GB2600627B (en) 2016-05-27 2022-12-07 Personalis Inc Personalized genetic testing
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
WO2017214068A1 (en) 2016-06-05 2017-12-14 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
US11779657B2 (en) 2016-06-10 2023-10-10 City Of Hope Compositions and methods for mitochondrial genome editing
EP3469083A1 (en) 2016-06-10 2019-04-17 Alnylam Pharmaceuticals, Inc. COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
US11788083B2 (en) 2016-06-17 2023-10-17 The Broad Institute, Inc. Type VI CRISPR orthologs and systems
EP3472354A4 (en) 2016-06-17 2020-01-01 California Institute of Technology NUCLEIC ACID ACTIONS AND RELATED PROCEDURES AND COMPOSITIONS
CA3028960A1 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
EP3472181A4 (en) 2016-06-20 2020-05-13 Healthtell Inc. METHOD FOR DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DISEASES
US20210222164A1 (en) 2016-06-29 2021-07-22 The Broad Institute, Inc. Crispr-cas systems having destabilization domain
CA3028370A1 (en) 2016-06-29 2018-01-04 Mitsubishi Chemical Corporation Composition for preventing drying of gel, gel composite and dna chip containing said composite, and method for producing said composition, composite, and chip
US10676734B2 (en) 2016-07-12 2020-06-09 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
WO2018013883A1 (en) 2016-07-14 2018-01-18 Caprion Proteomics Inc. Biomarkers of latent tuberculosis infection
EP3491560A1 (en) 2016-07-27 2019-06-05 Sequenom, Inc. Genetic copy number alteration classifications
WO2018025242A2 (en) 2016-08-04 2018-02-08 Baylor Research Institute Methods for diagnosing and treating esophageal cancer
EP3497446B1 (en) 2016-08-15 2021-04-28 F. Hoffmann-La Roche AG Method and composition for detection of peptide cyclization using protein tags
AU2017315294B2 (en) 2016-08-22 2023-12-21 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
CN110506127B (zh) 2016-08-24 2024-01-12 维拉科特Sd公司 基因组标签预测前列腺癌患者对术后放射疗法应答性的用途
WO2018053228A1 (en) 2016-09-15 2018-03-22 The Regents Of The University Of California Biomarkers for bipolar disorder and schizophrenia
CN110248724B (zh) 2016-09-21 2022-11-18 特韦斯特生物科学公司 基于核酸的数据存储
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ido及tdo調節之化合物及方法以及其適應症
AU2017332495A1 (en) 2016-09-24 2019-04-11 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
CA3034924A1 (en) 2016-09-26 2018-03-29 Cellular Research, Inc. Measurement of protein expression using reagents with barcoded oligonucleotide sequences
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
EP3535297B1 (en) 2016-11-02 2022-08-10 Debiopharm International, S.A. Methods for improving anti-cd37 immunoconjugate therapy
CN109952612B (zh) 2016-11-08 2023-12-01 贝克顿迪金森公司 用于表达谱分类的方法
KR20190077061A (ko) 2016-11-08 2019-07-02 셀룰러 리서치, 인크. 세포 표지 분류 방법
CA3043329A1 (en) 2016-11-09 2018-05-17 Healthtell Inc. Coatings with tunable amine density
KR20190082871A (ko) 2016-11-09 2019-07-10 헬스텔 인크. 선조립되고, 보호되고, 화학적으로 안정한, 화학선택적 링커
US11371990B2 (en) 2016-11-11 2022-06-28 Cowper Sciences Inc. Methods for identifying candidate biomarkers
US10646540B2 (en) 2016-11-18 2020-05-12 City Of Hope Peptide inhibitors of twist
WO2018098241A1 (en) 2016-11-22 2018-05-31 University Of Rochester Methods of assessing risk of recurrent prostate cancer
TWI788312B (zh) 2016-11-23 2023-01-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
CN110249082B (zh) 2016-12-01 2023-07-07 诺迪勒思附属公司 测定蛋白质的方法
KR20230166146A (ko) 2016-12-16 2023-12-06 알닐람 파마슈티칼스 인코포레이티드 트랜스티레틴(TTR) iRNA 조성물을 사용하여 TTR-관련 질병을 치료하거나 예방하는 방법
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
PT3554681T (pt) 2016-12-16 2022-03-21 Brigham & Womens Hospital Inc Método para matriz de sensores de coroa de proteínas para a deteção precoce de doenças
EA201991262A1 (ru) 2016-12-16 2020-04-07 Твист Байосайенс Корпорейшн Библиотеки вариантов иммунологического синапса и их синтез
AU2017395023B2 (en) 2016-12-23 2022-04-07 Plexxikon Inc. Compounds and methods for CDK8 modulation and indications therefor
WO2018132610A1 (en) 2017-01-13 2018-07-19 Cellular Research, Inc. Hydrophilic coating of fluidic channels
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
EP3571309A4 (en) 2017-01-20 2020-11-25 Children's Hospital Medical Center PROCEDURES AND COMPOSITIONS RELATED TO OPRM1 DNA METHYLATION FOR PERSONALIZED PAIN MANAGEMENT
US11694768B2 (en) 2017-01-24 2023-07-04 Sequenom, Inc. Methods and processes for assessment of genetic variations
CA3051512A1 (en) 2017-01-26 2018-08-02 Zlip Holding Limited Cd47 antigen binding unit and uses thereof
US20190390278A1 (en) 2017-01-26 2019-12-26 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
CN110892485B (zh) 2017-02-22 2024-03-22 特韦斯特生物科学公司 基于核酸的数据存储
EP3592868B1 (en) 2017-03-06 2022-11-23 Novartis AG Methods of treatment of cancer with reduced ubb expression
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
US11746381B2 (en) 2017-03-10 2023-09-05 Cancer Diagnostics Research Innvovations, LLC Methods for diagnosing and treating gastric cancer using miRNA expression
US10894959B2 (en) 2017-03-15 2021-01-19 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US11459618B2 (en) 2017-03-29 2022-10-04 Crown Bioscience, Inc. (Taicang) System and method for determining Cetuximab sensitivity on gastric cancer
US20200024351A1 (en) 2017-04-03 2020-01-23 Jounce Therapeutics, Inc. Compositions and Methods for the Treatment of Cancer
SG11201909572QA (en) 2017-04-18 2019-11-28 Alnylam Pharmaceuticals Inc Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
EP3615934A1 (en) 2017-04-28 2020-03-04 Merck Sharp & Dohme Corp. Biomarkers for cancer therapeutics
AU2018266675A1 (en) * 2017-05-09 2019-12-05 Revere Biosensors, Llc Systems and methods for identifying and distinguishing genetic samples
CA3062716A1 (en) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
CA3063283A1 (en) 2017-05-17 2018-11-22 Microbio Pty Ltd Methods and agents for identifying or classifying microbes based on polymorphisms within ribosomal rna genes
WO2018213690A1 (en) 2017-05-18 2018-11-22 The Rockefeller University Compositions and methods for diagnosing and treating diseases and disorders associated with mutant kcnj5
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
CA3063904A1 (en) 2017-05-22 2018-11-29 Edith Cowan University A method for the determination of early stage melanoma using autoantibody biomarkers
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
US11535886B2 (en) 2017-06-02 2022-12-27 Affymetrix, Inc. Array-based methods for analysing mixed samples using different allele-specific labels, in particular for detection of fetal aneuploidies
CN110914448A (zh) 2017-06-02 2020-03-24 昂飞股份有限公司 使用差异性标记的等位基因特异性探针分析混合样品的基于阵列的方法
WO2018223053A1 (en) 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
AU2018281745B2 (en) 2017-06-05 2022-05-19 Becton, Dickinson And Company Sample indexing for single cells
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
US10696965B2 (en) 2017-06-12 2020-06-30 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
EP3638814B8 (en) 2017-06-14 2023-06-21 The United States of America, as Represented by The Secretary, Department of Health and Human Services Method for determining lymphoma type
US11851651B2 (en) 2017-06-19 2023-12-26 Massachusetts Institute Of Technology Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
EP3655418A4 (en) 2017-06-22 2021-05-19 Triact Therapeutics, Inc. METHOD OF TREATMENT OF GLIOBLASTOMA
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
MX2019015047A (es) 2017-06-23 2020-08-03 Inscripta Inc Nucleasas guiadas por acidos nucleicos.
JP7277058B2 (ja) 2017-06-26 2023-05-18 フェーズ ジェノミクス インコーポレイテッド Dna配列のクラスター化のための方法
US11420941B2 (en) * 2017-06-29 2022-08-23 Cowper Sciences Inc. Methods and systems for mask alignment in manufacturing process of arrays
WO2019018764A1 (en) 2017-07-21 2019-01-24 Genecentric Therapeutics, Inc. METHODS OF DETERMINING RESPONSE TO PARP INHIBITORS
US11530413B2 (en) 2017-07-21 2022-12-20 Novartis Ag Compositions and methods to treat cancer
US12006554B2 (en) 2017-08-07 2024-06-11 Genecentric Therapeutics, Inc. Methods for subtyping of head and neck squamous cell carcinoma
US11427826B2 (en) 2017-08-11 2022-08-30 City of Hopw RNA aptamers against transferrin receptor (TfR)
WO2019036055A2 (en) 2017-08-18 2019-02-21 Ignite Biosciences, Inc. METHODS OF SELECTING BINDING REAGENTS
WO2019043504A1 (en) 2017-08-31 2019-03-07 Novartis Ag METHODS OF SELECTING TREATMENT FOR PATIENTS WITH CANCER
US10634614B2 (en) 2017-09-01 2020-04-28 Bio-Rad Laboratories, Inc. High powered lasers for western blotting
JP2020534812A (ja) 2017-09-08 2020-12-03 ライフ テクノロジーズ コーポレイション 改良された相同組換えおよびその組成物のための方法
CN111315890A (zh) 2017-09-08 2020-06-19 生命技术公司 提高同源重组的方法和其组合物
KR20200047706A (ko) 2017-09-11 2020-05-07 트위스트 바이오사이언스 코포레이션 Gpcr 결합 단백질 및 이의 합성 방법
US12025615B2 (en) 2017-09-15 2024-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Methods of classifying response to immunotherapy for cancer
US20200271643A1 (en) 2017-09-20 2020-08-27 Quanterix Corporation Methods and systems for the detection of analyte molecules
EP3687501A4 (en) 2017-09-29 2021-06-23 Triact Therapeutics, Inc. INIPARIB FORMS AND USES THEREOF
EP3696275A4 (en) 2017-10-11 2021-05-26 MGI Tech Co., Ltd. PROCESS FOR IMPROVING THE LOAD AND STABILITY OF NUCLEIC ACIDS ON A SOLID SUPPORT
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
US10894242B2 (en) 2017-10-20 2021-01-19 Twist Bioscience Corporation Heated nanowells for polynucleotide synthesis
US11721412B2 (en) 2017-10-23 2023-08-08 Nautilus Subsidiary, Inc. Methods for identifying a protein in a sample of unknown proteins
WO2019084434A1 (en) 2017-10-26 2019-05-02 National University Of Singapore NEW APPROACH FOR UNIVERSAL MONITORING OF MINIMUM RESIDUAL DISEASE IN ACUTE MYELOID LEUKEMIA
CN111226118A (zh) 2017-10-27 2020-06-02 加利福尼亚大学董事会 用于牙龈炎的唾液细胞外rna生物标记物
WO2019089922A1 (en) 2017-11-01 2019-05-09 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof
EP3704250A1 (en) 2017-11-03 2020-09-09 InteRNA Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
US20200385719A1 (en) 2017-11-16 2020-12-10 Alnylam Pharmaceuticals, Inc. Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
WO2019100039A1 (en) 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
WO2019113506A1 (en) 2017-12-07 2019-06-13 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
UY38003A (es) 2017-12-12 2019-06-28 Amgen Inc Construcciones de arni para inhibir la expresión de pnpla3 y métodos de uso de las mismas
US20200308588A1 (en) 2017-12-18 2020-10-01 Alnylam Pharmaceuticals, Inc. High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
US11939575B2 (en) 2017-12-19 2024-03-26 City Of Hope Modified tracrRNAs gRNAs, and uses thereof
EP3728321A1 (en) 2017-12-22 2020-10-28 F. Hoffmann-La Roche AG Use of pilra binding agents for treatment of a disease
MX2020006803A (es) 2017-12-29 2020-10-28 Nautilus Biotechnology Inc Estrategias de descodificacion para identificacion de proteinas.
EP3735459A4 (en) 2018-01-04 2021-10-06 Twist Bioscience Corporation DNA-BASED DIGITAL INFORMATION STORAGE
KR20200112906A (ko) 2018-01-25 2020-10-05 바이오젠 엠에이 인코포레이티드 척추 근위축증의 치료 방법
KR20220098056A (ko) 2018-02-09 2022-07-08 제넨테크, 인크. 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법
US11859250B1 (en) 2018-02-23 2024-01-02 Children's Hospital Medical Center Methods for treating eosinophilic esophagitis
JP7438966B2 (ja) 2018-04-04 2024-02-27 ノーティラス・サブシディアリー・インコーポレイテッド ナノアレイおよびマイクロアレイを製造する方法
IT201800004253A1 (it) 2018-04-05 2019-10-05 Composizioni e metodi per il trattamento della tachicardia ventricolare polimorfa catecolaminergica dominante ereditaria.
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
EP3788138A1 (en) 2018-05-02 2021-03-10 Novartis AG Regulators of human pluripotent stem cells and uses thereof
US11773441B2 (en) 2018-05-03 2023-10-03 Becton, Dickinson And Company High throughput multiomics sample analysis
WO2019213237A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
US20210386829A1 (en) 2018-05-04 2021-12-16 The Broad Institute, Inc. Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
US20210380629A1 (en) 2018-05-09 2021-12-09 Vibrant Holdings, Llc Methods of synthesizing a polynucleotide array using photoactivated agents
FI3794122T3 (fi) 2018-05-14 2023-11-07 Alnylam Pharmaceuticals Inc Angiotensinogeenin (AGT) IRNA-koostumuksia ja niiden käyttömenetelmä
CN112639130B (zh) 2018-05-18 2024-08-09 特韦斯特生物科学公司 用于核酸杂交的多核苷酸、试剂和方法
CN112533695A (zh) * 2018-05-29 2021-03-19 生捷科技控股公司 在基材提高光化学反应的效率
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
NL2021377B1 (en) 2018-07-03 2020-01-08 Illumina Inc Interposer with first and second adhesive layers
US20210265006A1 (en) 2018-07-24 2021-08-26 Affymetrix, Inc. Array based method and kit for determining copy number and genotype in pseudogenes
ES2935891T3 (es) 2018-08-08 2023-03-13 Pml Screening Llc Métodos para evaluar el riesgo de desarrollar leucoencefalopatía multifocal progresiva causada por virus de John Cunningham mediante pruebas genéticas
MX2021001056A (es) 2018-08-13 2021-04-12 Alnylam Pharmaceuticals Inc Composiciones de agente de acido ribonucleico bicatenario (arnbc) de virus de la hepatitis b (vhb) y metodos de uso de las mismas.
WO2020036926A1 (en) 2018-08-17 2020-02-20 Cellecta, Inc. Multiplex preparation of barcoded gene specific dna fragments
US20210317429A1 (en) 2018-08-20 2021-10-14 The Broad Institute, Inc. Methods and compositions for optochemical control of crispr-cas9
EP3850368A4 (en) 2018-09-14 2022-11-23 Prelude Corporation PROCEDURE FOR SELECTING THE TREATMENT OF SUBJECTS AT RISK FOR INVASIVE BREAST CANCER
WO2020060986A1 (en) 2018-09-18 2020-03-26 Alnylam Pharmaceuticals, Inc. Ketohexokinase (khk) irna compositions and methods of use thereof
JP2022501388A (ja) 2018-09-19 2022-01-06 ラホヤ インスティチュート フォー イミュノロジー 関節リウマチにおけるptprs及びプロテオグリカン
CA3114396A1 (en) 2018-09-28 2020-04-02 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
US20210349097A1 (en) 2018-10-05 2021-11-11 Eisai R&D Management Co., Ltd. Biomarkers for a combination therapy comprising lenvatinib and everolimus
EP3861346A1 (en) 2018-10-05 2021-08-11 Eisai R&D Management Co., Ltd. Biomarkers for a therapy comprising a sorafenib compound
WO2020076897A1 (en) 2018-10-09 2020-04-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
US20220401460A1 (en) 2018-10-10 2022-12-22 Dana-Farber Cancer Institute, Inc. Modulating resistance to bcl-2 inhibitors
CA3116539C (en) 2018-10-18 2023-10-03 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (sle) disease activity immune index that characterizes disease activity
WO2020096631A2 (en) 2018-11-07 2020-05-14 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
US11993865B2 (en) 2018-11-20 2024-05-28 Nautilus Subsidiary, Inc. Selection of affinity reagents
EP3660172A1 (en) 2018-11-28 2020-06-03 Bioscreening and Diagnostics LLC Method for detection of traumatic brain injury (tbi)
EP4369356A3 (en) 2018-11-30 2024-07-24 Caris MPI, Inc. Next-generation molecular profiling
JP7499767B2 (ja) 2018-12-07 2024-06-14 エレメント バイオサイエンシーズ,インク. フローセルデバイスおよびその使用
US20220017906A1 (en) 2018-12-10 2022-01-20 Amgen Inc. Rnai constructs for inhibiting pnpla3 expression and methods of use thereof
CN113195717A (zh) 2018-12-13 2021-07-30 贝克顿迪金森公司 单细胞全转录组分析中的选择性延伸
CA3124110A1 (en) 2018-12-17 2020-06-25 The Broad Institute, Inc. Crispr-associated transposase systems and methods of use thereof
JP2022515744A (ja) 2018-12-20 2022-02-22 プラクシス プレシジョン メディシンズ, インコーポレイテッド Kcnt1関連障害の治療のための組成物及び方法
EP3677693A1 (en) 2019-01-03 2020-07-08 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Transpochimeric gene trancripts (tcgts) as cancer biomarkers
US11371076B2 (en) 2019-01-16 2022-06-28 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
ES2945227T3 (es) 2019-01-23 2023-06-29 Becton Dickinson Co Oligonucleótidos asociados con anticuerpos
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
CN113365661A (zh) 2019-01-31 2021-09-07 新加坡科技研究局 用于治疗或预防癌症的cnx/erp57抑制剂
CA3126432A1 (en) 2019-02-01 2020-08-06 Health Research, Inc. Methods and compositions for treating resistant and recurrent forms of cancer
EP3924739A1 (en) 2019-02-12 2021-12-22 Biogen MA Inc. Biomarkers of progressive multifocal leukoencephalopathy
US12071617B2 (en) 2019-02-14 2024-08-27 Becton, Dickinson And Company Hybrid targeted and whole transcriptome amplification
SG11202109322TA (en) 2019-02-26 2021-09-29 Twist Bioscience Corp Variant nucleic acid libraries for glp1 receptor
CA3131691A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
AU2020228047A1 (en) 2019-02-27 2021-09-30 Madera Therapeutics, LLC Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
WO2020186101A1 (en) 2019-03-12 2020-09-17 The Broad Institute, Inc. Detection means, compositions and methods for modulating synovial sarcoma cells
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIMED FLUORESCENCE-BASED DETECTION
WO2020186235A1 (en) 2019-03-14 2020-09-17 The Broad Institute, Inc. Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells
US20220142948A1 (en) 2019-03-18 2022-05-12 The Broad Institute, Inc. Compositions and methods for modulating metabolic regulators of t cell pathogenicity
US20220152148A1 (en) 2019-03-18 2022-05-19 The Broad Institute, Inc. Modulation of type 2 immunity by targeting clec-2 signaling
WO2020191102A1 (en) 2019-03-18 2020-09-24 The Broad Institute, Inc. Type vii crispr proteins and systems
US20220175848A1 (en) 2019-04-01 2022-06-09 The Broad Institute, Inc. Methods and compositions for cell therapy
WO2020201267A1 (en) 2019-04-01 2020-10-08 Københavns Universitet Identification of pan-gamma secretase inhibitor (pan-gsi) theranostic response signatures for cancers
CN113924085A (zh) 2019-04-12 2022-01-11 加利福尼亚大学董事会 用于增加肌肉量和氧化代谢的组合物和方法
US20220220564A1 (en) 2019-04-17 2022-07-14 Igenomix, S.L. Improved methods for the early diagnosis of uterine leiomyomas and leiomyosarcomas
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
CA3138566A1 (en) 2019-04-30 2020-11-05 Larimar Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
EP3965932B1 (en) 2019-05-08 2024-08-14 Scienion GmbH Assay plate with nano-vessels and sample recovery assembly
WO2020230047A1 (en) 2019-05-15 2020-11-19 Affinito Alessadra Aptamers against glioblastoma
WO2020236967A1 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Random crispr-cas deletion mutant
UY38733A (es) 2019-05-30 2020-11-30 Amgen Inc Construcciones de arni para inhibir la expresión de scap y métodos de uso de las mismas
WO2020245198A1 (en) 2019-06-04 2020-12-10 Apterna Limited APTAMERS AGAINST TRANSFERRIN RECEPTOR (TfR)
PE20220256A1 (es) 2019-06-07 2022-02-21 Scribe Therapeutics Inc Sistemas de casx artificiales
CA3144644A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
AU2020302791A1 (en) 2019-06-27 2022-02-03 Dovetail Genomics, Llc Methods and compositions for proximity ligation
WO2020264441A1 (en) 2019-06-27 2020-12-30 Roche Sequencing Solutions, Inc. Peptide libraries having enhanced subsequence diversity and methods for use thereof
CN114051534A (zh) 2019-07-22 2022-02-15 贝克顿迪金森公司 单细胞染色质免疫沉淀测序测定
WO2021022108A2 (en) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2021022109A1 (en) 2019-08-01 2021-02-04 Alnylam Pharmaceuticals, Inc. SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
IL303893A (en) 2019-08-05 2023-08-01 Seer Inc Systems and methods for sample preparation, data generation and corona protein analysis
EP4013870A1 (en) 2019-08-13 2022-06-22 Alnylam Pharmaceuticals, Inc. Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
US20220282333A1 (en) 2019-08-13 2022-09-08 The General Hospital Corporation Methods for predicting outcomes of checkpoint inhibition and treatment thereof
CA3150758A1 (en) 2019-08-13 2021-02-18 Amgen Inc. Rnai constructs for inhibiting slc30a8 expression and methods of use thereof
US20220298501A1 (en) 2019-08-30 2022-09-22 The Broad Institute, Inc. Crispr-associated mu transposase systems
US20220348925A1 (en) 2019-09-09 2022-11-03 Scribe Therapeutics Inc. Compositions and methods for the targeting of sod1
CN114729368A (zh) 2019-09-09 2022-07-08 斯克里贝治疗公司 用于免疫疗法的组合物和方法
PE20221416A1 (es) 2019-09-18 2022-09-20 Novartis Ag Proteinas de fusion nkg2d y sus usos
KR20220066151A (ko) 2019-09-23 2022-05-23 트위스트 바이오사이언스 코포레이션 Crth2에 대한 변이체 핵산 라이브러리
EP4038222A4 (en) 2019-10-02 2023-10-18 Arizona Board of Regents on behalf of Arizona State University METHODS AND COMPOSITIONS FOR IDENTIFYING NEOANTIGENS FOR USE IN THE TREATMENT AND PREVENTION OF CANCER
US11981922B2 (en) 2019-10-03 2024-05-14 Dana-Farber Cancer Institute, Inc. Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
US11793787B2 (en) 2019-10-07 2023-10-24 The Broad Institute, Inc. Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
EP4045652A1 (en) 2019-10-18 2022-08-24 Alnylam Pharmaceuticals, Inc. Solute carrier family member irna compositions and methods of use thereof
JP2022553348A (ja) 2019-10-22 2022-12-22 アルナイラム ファーマシューティカルズ, インコーポレイテッド 補体成分C3 iRNA組成物およびその使用方法
WO2021086982A2 (en) 2019-10-28 2021-05-06 Beckman Coulter, Inc. Compounds for the identification of microbial classes and uses thereof
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
TW202132567A (zh) 2019-11-01 2021-09-01 美商阿尼拉製藥公司 亨汀頓蛋白(HTT)iRNA劑組成物及其使用方法
WO2021092145A1 (en) 2019-11-06 2021-05-14 Alnylam Pharmaceuticals, Inc. Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
JP7522189B2 (ja) 2019-11-08 2024-07-24 ベクトン・ディキンソン・アンド・カンパニー 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用
EP4061945A1 (en) 2019-11-22 2022-09-28 Alnylam Pharmaceuticals, Inc. Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
JP2023504270A (ja) 2019-12-02 2023-02-02 カリス エムピーアイ インコーポレイテッド 汎がんのプラチナ反応予測子
US20230033866A1 (en) 2019-12-06 2023-02-02 Scribe Therapeutics Inc. Compositions and methods for the targeting of rhodopsin
EP4069846A1 (en) 2019-12-07 2022-10-12 Scribe Therapeutics Inc. Compositions and methods for the targeting of htt
TW202140509A (zh) 2019-12-13 2021-11-01 美商阿尼拉製藥公司 人類染色體9開讀框72(C9ORF72)iRNA劑組成物及其使用方法
TW202138559A (zh) 2019-12-16 2021-10-16 美商阿尼拉製藥公司 含類PATATIN磷脂酶結構域3(PNPLA3)iRNA組成物及其使用方法
US20230044602A1 (en) 2019-12-20 2023-02-09 EDWARD Via COLLEGE OF OSTEOPATHIC MEDICINE Cancer signatures, methods of generating cancer signatures, and uses thereof
WO2021142342A1 (en) 2020-01-10 2021-07-15 Scribe Therapeutics Inc. Compositions and methods for the targeting of pcsk9
CA3164510A1 (en) 2020-01-13 2021-07-22 Yasmin RAMSAY Methods for the treatment of cancer
EP4090763A1 (en) 2020-01-13 2022-11-23 Becton Dickinson and Company Methods and compositions for quantitation of proteins and rna
WO2021154941A1 (en) 2020-01-31 2021-08-05 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
CN113275053A (zh) 2020-02-03 2021-08-20 帝肯基因组学公司 试剂存储系统
CN115380122A (zh) 2020-02-10 2022-11-22 奥布赛瓦股份公司 用于催产素受体拮抗剂疗法的生物标志物
WO2021167841A1 (en) 2020-02-18 2021-08-26 Alnylam Pharmaceuticals, Inc. Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
WO2021178607A1 (en) 2020-03-05 2021-09-10 Alnylam Pharmaceuticals, Inc. Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
BR112022017822A2 (pt) 2020-03-06 2022-11-08 Alnylam Pharmaceuticals Inc Composições de irna de cetoexocinase (khk) e métodos de uso das mesmas
WO2021188611A1 (en) 2020-03-18 2021-09-23 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
EP4121535A1 (en) 2020-03-18 2023-01-25 Scribe Therapeutics Inc. Compositions and methods for the targeting of c9orf72
JP2023519274A (ja) 2020-03-26 2023-05-10 アルナイラム ファーマシューティカルズ, インコーポレイテッド コロナウイルスiRNA組成物およびその使用方法
WO2021206922A1 (en) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
WO2021206917A1 (en) 2020-04-07 2021-10-14 Alnylam Pharmaceuticals, Inc. ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2021211754A2 (en) 2020-04-15 2021-10-21 Quanterix Corporation Methods and systems related to highly sensitive assays and delivering capture objects
BR112022021813A2 (pt) 2020-04-27 2023-01-17 Alnylam Pharmaceuticals Inc Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
IL297680A (en) 2020-04-30 2022-12-01 Alnylam Pharmaceuticals Inc IRNA compounds complement factor b (cfb) and methods of using them
EP4146797A1 (en) 2020-05-06 2023-03-15 Orchard Therapeutics (Europe) Limited Treatment for neurodegenerative diseases
WO2021224408A2 (en) 2020-05-08 2021-11-11 Scienion Ag Assay plate with nano-vessels and sample recovery assembly
EP4150118A1 (en) 2020-05-14 2023-03-22 Becton Dickinson and Company Primers for immune repertoire profiling
EP4150078A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
WO2021231675A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
EP4150076A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
EP4150087A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
WO2021231691A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
WO2021231673A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
WO2021231692A1 (en) 2020-05-15 2021-11-18 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of otoferlin (otof)
EP4150077A1 (en) 2020-05-15 2023-03-22 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
AU2021284377A1 (en) 2020-06-01 2022-12-22 Amgen Inc. RNAi constructs for inhibiting HSD17B13 expression and methods of use thereof
US11408000B2 (en) 2020-06-03 2022-08-09 Triplet Therapeutics, Inc. Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
WO2021252557A1 (en) 2020-06-09 2021-12-16 Alnylam Pharmaceuticals, Inc. Rnai compositions and methods of use thereof for delivery by inhalation
EP4168546A1 (en) 2020-06-18 2023-04-26 Alnylam Pharmaceuticals, Inc. Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
AU2021305665A1 (en) 2020-07-10 2023-02-23 Centre National De La Recherche Scientifique Methods and compositions for treating epilepsy
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
WO2022058427A1 (en) 2020-09-16 2022-03-24 Novigenix Sa Biomarkers for immune checkpoint inhibitors treatment
WO2022066847A1 (en) 2020-09-24 2022-03-31 Alnylam Pharmaceuticals, Inc. Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
JP2023544413A (ja) 2020-10-05 2023-10-23 アルナイラム ファーマシューティカルズ, インコーポレイテッド Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
WO2022087329A1 (en) 2020-10-23 2022-04-28 Alnylam Pharmaceuticals, Inc. Mucin 5b (muc5b) irna compositions and methods of use thereof
US11692217B2 (en) 2020-11-11 2023-07-04 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
WO2022103999A1 (en) 2020-11-13 2022-05-19 Alnylam Pharmaceuticals, Inc. COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
JP2023549872A (ja) 2020-11-18 2023-11-29 アストラゼネカ・アクチエボラーグ ステロイド節約
EP4247967A1 (en) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profiling of highly expressed and lowly expressed proteins
WO2022119873A1 (en) 2020-12-01 2022-06-09 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
TW202237836A (zh) 2020-12-03 2022-10-01 美商斯奎柏治療公司 工程化之第2類第v型crispr系統
US20240100185A1 (en) 2020-12-03 2024-03-28 Scribe Therapeutics Inc. Compositions and methods for the targeting of ptbp1
EP4259795A1 (en) 2020-12-08 2023-10-18 Alnylam Pharmaceuticals, Inc. Coagulation factor x (f10) irna compositions and methods of use thereof
US20240055076A1 (en) 2020-12-09 2024-02-15 Cambridge Enterprise Limited Treatment of diseases associated with variant novel open reading frames
GB202019692D0 (en) 2020-12-14 2021-01-27 Apterna Ltd Aptamer-sirna fusions
US20240060071A1 (en) 2020-12-16 2024-02-22 Cambridge Enterprise Limited Treatment of cancer associated with dysregulated novel open reading frame products
WO2022130261A1 (en) 2020-12-16 2022-06-23 Cambridge Enterprise Limited Treatment of cancer associated with variant novel open reading frames
WO2022150260A1 (en) 2021-01-05 2022-07-14 Alnylam Pharmaceuticals, Inc. COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
WO2022162588A1 (en) 2021-01-28 2022-08-04 Cambridge Enterprise Limited Method of treatment of malaria by targetting open reading frames
KR20230146048A (ko) 2021-02-12 2023-10-18 알닐람 파마슈티칼스 인코포레이티드 슈퍼옥사이드 디스뮤타제 1(sod1) irna 조성물 및 슈퍼옥사이드 디스뮤타제 1- (sod1-) 관련 신경퇴행성 질환을 치료하거나 예방하기 위한 이의 사용 방법
WO2022175815A1 (en) 2021-02-19 2022-08-25 Pfizer Inc. Methods of protecting rna
WO2022182864A1 (en) 2021-02-25 2022-09-01 Alnylam Pharmaceuticals, Inc. Prion protein (prnp) irna compositions and methods and methods of use thereof
EP4298218A1 (en) 2021-02-26 2024-01-03 Alnylam Pharmaceuticals, Inc. Ketohexokinase (khk) irna compositions and methods of use thereof
WO2022187435A1 (en) 2021-03-04 2022-09-09 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
WO2022192419A2 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Methods of treating inflammatory bowel disease (ibd) with anti- tnf-blockade
EP4305169A1 (en) 2021-03-12 2024-01-17 Alnylam Pharmaceuticals, Inc. Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
MX2023011466A (es) 2021-03-29 2024-02-01 Alnylam Pharmaceuticals Inc Composiciones de agentes de ácido ribonucleico de interferencia (arni) de huntingtina (htt) y métodos de uso de estas.
WO2022212153A1 (en) 2021-04-01 2022-10-06 Alnylam Pharmaceuticals, Inc. Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
CN118661103A (zh) 2021-04-06 2024-09-17 布普格生物制药公司 雌激素受体(er)阳性样和雌激素受体(er)阴性样乳腺癌的蛋白质标志物
IL307530A (en) 2021-04-06 2023-12-01 Bpgbio Inc Estrogen receptor-like (ER) breast cancer protein markers LUMINAL A (LA) and LUMINAL B1 (LB1)
EP4330392A1 (en) 2021-04-26 2024-03-06 Alnylam Pharmaceuticals, Inc. Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
EP4330396A1 (en) 2021-04-29 2024-03-06 Alnylam Pharmaceuticals, Inc. Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
WO2022237974A1 (en) 2021-05-12 2022-11-17 Ecole Polytechnique Federale De Lausanne (Epfl) Krab-containing zinc finger protein and cancer
EP4341401A1 (en) 2021-05-18 2024-03-27 Alnylam Pharmaceuticals, Inc. Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
US20240263177A1 (en) 2021-05-20 2024-08-08 Korro Bio, Inc. Methods and Compositions for Adar-Mediated Editing
US20240247264A1 (en) 2021-05-28 2024-07-25 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) NOVEL lncRNA CONTROLLING CARDIAC FIBROSIS
WO2022256283A2 (en) 2021-06-01 2022-12-08 Korro Bio, Inc. Methods for restoring protein function using adar
TW202317762A (zh) 2021-06-02 2023-05-01 美商艾拉倫製藥股份有限公司 含有類PATATIN磷脂酶結構域3(PNPLA3)的iRNA組成物及其使用方法
KR20240017911A (ko) 2021-06-04 2024-02-08 알닐람 파마슈티칼스 인코포레이티드 인간 염색체 9 개방 해독 프레임 72(C9orf72) iRNA 제제 조성물 및 이의 사용 방법
EP4351541A2 (en) 2021-06-08 2024-04-17 Alnylam Pharmaceuticals, Inc. Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders
US11756285B2 (en) 2021-06-10 2023-09-12 Bank Of America Corporation Image processing system and method for image noise removal
EP4363574A1 (en) 2021-06-29 2024-05-08 Korro Bio, Inc. Methods and compositions for adar-mediated editing
US20230194709A9 (en) 2021-06-29 2023-06-22 Seagate Technology Llc Range information detection using coherent pulse sets with selected waveform characteristics
WO2023288252A1 (en) 2021-07-13 2023-01-19 Truebinding, Inc. Methods of preventing protein aggregation
US20240263238A1 (en) 2021-07-14 2024-08-08 Cambridge Enterprise Limited Treatment of schizophrenia and bipolar disorder
AU2022314619A1 (en) 2021-07-21 2024-01-04 Alnylam Pharmaceuticals, Inc. Metabolic disorder-associated target gene irna compositions and methods of use thereof
TW202325312A (zh) 2021-07-23 2023-07-01 美商艾拉倫製藥股份有限公司 β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法
EP4377458A1 (en) 2021-07-29 2024-06-05 Alnylam Pharmaceuticals, Inc. 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
CN117795074A (zh) 2021-08-03 2024-03-29 阿尔尼拉姆医药品有限公司 转甲状腺素蛋白(TTR)iRNA组合物和其使用方法
JP2024531914A (ja) 2021-08-04 2024-09-03 アルナイラム ファーマシューティカルズ, インコーポレイテッド アンジオテンシノーゲン(agt)をサイレンシングするためのirna組成物および方法
AU2022328347A1 (en) 2021-08-13 2024-02-08 Alnylam Pharmaceuticals, Inc. Factor xii (f12) irna compositions and methods of use thereof
EP4401742A2 (en) 2021-09-17 2024-07-24 Alnylam Pharmaceuticals, Inc. Irna compositions and methods for silencing complement component 3 (c3)
CA3232420A1 (en) 2021-09-20 2023-03-23 Alnylam Pharmaceuticals, Inc. Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
AU2022364838A1 (en) 2021-10-15 2024-04-11 Alnylam Pharmaceuticals, Inc. Extra-hepatic delivery irna compositions and methods of use thereof
MX2024004913A (es) 2021-10-22 2024-05-06 Amgen Inc Constructos de arni para inhibir la expresion de gpam y metodos de uso de los mismos.
AU2022370009A1 (en) 2021-10-22 2024-05-16 Korro Bio, Inc. Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
EP4423273A1 (en) 2021-10-29 2024-09-04 Alnylam Pharmaceuticals, Inc. Complement factor b (cfb) irna compositions and methods of use thereof
EP4423272A2 (en) 2021-10-29 2024-09-04 Alnylam Pharmaceuticals, Inc. Huntingtin (htt) irna agent compositions and methods of use thereof
IL313660A (en) 2021-12-22 2024-08-01 Camp4 Therapeutics Corp Modulation of gene transcription using antisense oligonucleotides targeting regulatory RNAs
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129764A1 (en) 2021-12-29 2023-07-06 Illumina Software, Inc. Automatically switching variant analysis model versions for genomic analysis applications
WO2023141314A2 (en) 2022-01-24 2023-07-27 Alnylam Pharmaceuticals, Inc. Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
US20230264294A1 (en) * 2022-02-23 2023-08-24 Corning Incorporated Methods of preparing a workpiece for laser bonding
US20230357851A1 (en) 2022-04-06 2023-11-09 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin-replacement therapy
WO2023200259A1 (ko) * 2022-04-13 2023-10-19 고려대학교 산학협력단 정밀 dna 광학 합성을 위한 시스템 및 방법
WO2023235818A2 (en) 2022-06-02 2023-12-07 Scribe Therapeutics Inc. Engineered class 2 type v crispr systems
TW202405175A (zh) 2022-06-07 2024-02-01 美商斯奎柏治療公司 用於靶向pcsk9的組合物及方法
TW202413643A (zh) 2022-06-07 2024-04-01 美商斯奎柏治療公司 用於靶向pcsk9的組合物及方法
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2023240277A2 (en) 2022-06-10 2023-12-14 Camp4 Therapeutics Corporation Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
WO2024020572A1 (en) 2022-07-22 2024-01-25 New York Stem Cell Foundation, Inc. Methods and compositions for the treatment of ptsd
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2024039776A2 (en) 2022-08-18 2024-02-22 Alnylam Pharmaceuticals, Inc. Universal non-targeting sirna compositions and methods of use thereof
WO2024056902A2 (en) 2022-09-16 2024-03-21 Christopher Shaw Compositions and methods for treating neurological diseases
WO2024119145A1 (en) 2022-12-01 2024-06-06 Camp4 Therapeutics Corporation Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
WO2024124044A1 (en) 2022-12-07 2024-06-13 The Brigham And Women’S Hospital, Inc. Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
WO2024126696A1 (en) 2022-12-14 2024-06-20 King's College London Compositions and methods for treating neurological diseases
WO2024130142A2 (en) 2022-12-16 2024-06-20 Amgen Inc. Rnai constructs for inhibiting ttr expression and methods of use thereof
WO2024160683A1 (en) 2023-01-30 2024-08-08 Ecole Polytechnique Federale De Lausanne (Epfl) Pou5f1b inhibitors
WO2024161022A2 (en) 2023-02-03 2024-08-08 King's College London Compositions and methods for treating neurological diseases
WO2024168010A2 (en) 2023-02-09 2024-08-15 Alnylam Pharmaceuticals, Inc. Reversir molecules and methods of use thereof

Family Cites Families (306)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR333561A (fr) 1903-07-03 1903-11-28 Georges Rollet Procédé et appareil pour le nettoyage des vetements
US3862056A (en) * 1967-12-15 1975-01-21 Allied Chem Semiconductor polymer compositions comprising a grafted block copolymer of synthetic rubber and polyolefin and carbon black
IL33640A (en) * 1969-01-16 1973-05-31 Kabi Ab Test strip packaged-unit
US3730844A (en) 1971-08-27 1973-05-01 Purdue Research Foundation Polynucleotide analysis
DE2150691C2 (de) * 1971-10-12 1982-09-09 Basf Ag, 6700 Ludwigshafen Lichtempfindliches Gemisch und Verwendung eines lichtempfindlichen Gemisches zur Herstellung einer Flachdruckplatte
DE2242394A1 (de) * 1972-08-29 1974-03-14 Basf Ag Unter lichteinwirkung haertbare stoffgemische
JPS5183B2 (ja) * 1973-03-07 1976-01-05
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
JPS6112373B2 (ja) * 1974-09-04 1986-04-08 Hitachi Ltd
SE407115B (sv) * 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
US4238757A (en) * 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
DE2612359C3 (de) 1976-03-24 1978-10-26 Konishiroku Photo Ind. Co., Ltd., Tokio Elektrophotographisches Aufzeichnungsmaterial
US4259223A (en) * 1976-03-29 1981-03-31 California Institute Of Technology Cross-linked polyvinyl pyridine coated glass particle catalyst support and aqueous composition or polyvinyl pyridine adducted microspheres
US4145406A (en) * 1977-04-11 1979-03-20 Miles Laboratories, Inc. Specific binding - adsorbent assay method and test means
US4086254A (en) * 1977-04-13 1978-04-25 The Upjohn Company Photocleavable steroids
US4121222A (en) 1977-09-06 1978-10-17 A. B. Dick Company Drop counter ink replenishing system
US4180739A (en) 1977-12-23 1979-12-25 Varian Associates, Inc. Thermostatable flow cell for fluorescence measurements
US4448534A (en) * 1978-03-30 1984-05-15 American Hospital Corporation Antibiotic susceptibility testing
US4269933A (en) 1978-06-08 1981-05-26 E. I. Du Pont De Nemours And Company Methods of developing photopolymerizable compositions containing an 0-nitroaromatic compound as photoinhibitor
US4216245A (en) 1978-07-25 1980-08-05 Miles Laboratories, Inc. Method of making printed reagent test devices
US4258001A (en) * 1978-12-27 1981-03-24 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4427415A (en) * 1979-01-05 1984-01-24 Cleveland Patrick H Manifold vacuum biochemical test method and device
US4314821A (en) * 1979-04-09 1982-02-09 Minnesota Mining And Manufacturing Company Sandwich immunoassay using piezoelectric oscillator
US4342905A (en) 1979-08-31 1982-08-03 Nippon Kogaku K.K. Automatic focusing device of a microscope
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4327073A (en) 1980-04-07 1982-04-27 Huang Henry V Automated method for quantitative analysis of biological fluids
US4478967A (en) 1980-08-11 1984-10-23 Minnesota Mining And Manufacturing Company Photolabile blocked surfactants and compositions containing the same
US4444892A (en) * 1980-10-20 1984-04-24 Malmros Mark K Analytical device having semiconductive organic polymeric element associated with analyte-binding substance
IL61351A (en) * 1980-10-27 1983-12-30 Yeda Res & Dev Organometallic polymers,their preparation and compositions of co-ordination compounds containing them
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
AR231590A1 (es) 1981-04-29 1984-12-28 Ciba Geigy Ag Dispositivo de analisis inmunologico y procedimiento para obtenerlo
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4339528A (en) * 1981-05-19 1982-07-13 Rca Corporation Etching method using a hardened PVA stencil
US4430299A (en) * 1981-06-18 1984-02-07 Coulter Electronics, Inc. Apparatus for monitoring chemical reactions
US4498774A (en) 1981-07-22 1985-02-12 Iowa State University Research Foundation, Inc. Micro-polarimeter for high performance liquid chromatography
US4395486A (en) 1981-08-19 1983-07-26 Medical College Of Ga. Research Inst., Inc. Method for the direct analysis of sickle cell anemia
USRE33064E (en) * 1981-09-18 1989-09-19 Prutec Limited Method for the determination of species in solution with an optical wave-guide
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4444878A (en) * 1981-12-21 1984-04-24 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
US5073484A (en) * 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4500919A (en) 1982-05-04 1985-02-19 Massachusetts Institute Of Technology Color reproduction system
US4483920A (en) 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US4556643A (en) 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4477556A (en) 1982-08-18 1984-10-16 E. I. Du Pont De Nemours And Company Acidic o-nitroaromatics as photoinhibitors of polymerization in positive working films
US4455089A (en) 1982-08-25 1984-06-19 Iowa State University Research Foundation, Inc. Refractive index and absorption detector for liquid chromatography based on Fabry-Perot interferometry
US5599720A (en) 1982-08-27 1997-02-04 Multilyte Limited Measurement of analyte concentration
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US4588682A (en) 1982-12-13 1986-05-13 Integrated Genetics, Inc. Binding nucleic acid to a support
EP0112721B1 (en) 1982-12-21 1988-05-18 Ares-Serono N.V. Assay technique
US4516833A (en) 1982-12-27 1985-05-14 University Of Dayton Production of high performance optical spatial filters
DE3301833A1 (de) * 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4575433A (en) 1983-01-31 1986-03-11 Iowa State University Research Foundation, Inc. Method of generating chemiluminescent light
US4634574A (en) 1983-01-31 1987-01-06 Iowa State Research Foundation, Inc. Apparatus for use in sulfide chemiluminescence detection
US4555491A (en) 1983-01-31 1985-11-26 Iowa State University Research Foundation, Inc. Sulfide chemiluminescence detection
US4591570A (en) 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4537861A (en) 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4584277A (en) 1983-04-05 1986-04-22 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4533682A (en) 1983-04-29 1985-08-06 Desoto, Inc. Imidazolidine-blocked amine polymers
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4517338A (en) * 1983-06-20 1985-05-14 Chiron Corporation Multiple reactor system and method for polynucleotide synthesis
US4987065A (en) 1983-07-05 1991-01-22 Enzo Biochem, Inc. In vivo labelling of polynucleotide sequences
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4626684A (en) * 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US4677054A (en) 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
US4719615A (en) * 1983-08-22 1988-01-12 Optical Data, Inc. Erasable optical data storage medium
US4598049A (en) 1983-08-31 1986-07-01 Systec Inc. General purpose gene synthesizer
WO1985001051A1 (en) 1983-09-02 1985-03-14 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
US4569967A (en) * 1983-10-24 1986-02-11 The Salk Institute For Biological Studies Synthesis of N-substituted peptide amides
US4580895A (en) * 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5821058A (en) 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
US5171534A (en) 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US4613566A (en) 1984-01-23 1986-09-23 President And Fellows Of Harvard College Hybridization assay and kit therefor
JPS60155942A (ja) 1984-01-25 1985-08-16 Fuji Photo Film Co Ltd 液体試料点着装置
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4704353A (en) * 1984-04-27 1987-11-03 Molecular Devices Corporation Photoresponsive redox detection and discrimination
DE3565986D1 (en) 1984-05-02 1988-12-08 Brendan James Hamill An apparatus for the chemical synthesis of oligonucleotides
US4766062A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4670380A (en) 1984-05-23 1987-06-02 Molecular Diagnostics, Inc. Assays utilizing labeled nucleic acid probes
JPS60248699A (ja) * 1984-05-23 1985-12-09 Fujisawa Pharmaceut Co Ltd ウロガストロンの製造法
US4555490A (en) * 1984-06-08 1985-11-26 The United States Of America As Represented By The Department Of Health And Human Services Rapid visualization system for gel electrophoresis
IL75464A (en) 1984-06-12 1990-08-31 Orgenics Ltd Method and apparatus for multi-analyte assay
CA1255586A (en) * 1984-07-24 1989-06-13 Hendrik M. Geysen Method of determining mimotopes
US4767927A (en) 1984-08-16 1988-08-30 Kabushiki Kaisha Toshiba Apparatus for reading radiation image information stored in imaging plate
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4563417A (en) * 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4681859A (en) * 1984-09-21 1987-07-21 Ortho Diagnostic Systems Inc. Fluorescence polarization immunoassay for heavy antigens
US5258506A (en) 1984-10-16 1993-11-02 Chiron Corporation Photolabile reagents for incorporation into oligonucleotide chains
DE3440141A1 (de) * 1984-11-02 1986-05-07 Heiner Dipl.-Chem. Dr. 8000 München Eckert Verwendung von kohlensaeure-bis-trichlormethylester als proreagens fuer phosgen
US4820630A (en) 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4719179A (en) 1984-11-30 1988-01-12 Pharmacia P-L Biochemicals, Inc. Six base oligonucleotide linkers and methods for their use
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US5064754A (en) 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
US4670379A (en) 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
US5026840A (en) * 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US4767700A (en) 1985-02-15 1988-08-30 Beckman Research Institute Of The City Of Hope Detection of particular nucleotide sequences
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
EP0194132A3 (en) * 1985-03-06 1988-08-03 Murex Corporation Imaging immunoassay detection system and method
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
DE3513168A1 (de) * 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
US4720786A (en) * 1985-04-19 1988-01-19 Fuji Photo Film Co., Ltd. Method of compensating for offset distortion in rows of electrophoretic patterns
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
WO1986006487A1 (en) * 1985-04-22 1986-11-06 Commonwealth Serum Laboratories Commission Method for determining mimotopes
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
JPS61290311A (ja) 1985-06-19 1986-12-20 Hitachi Ltd はんだ付部の検査装置及びその方法
FR2583772B1 (fr) 1985-06-20 1987-08-28 Roussel Uclaf Nouveaux supports, la preparation de ces supports, les intermediaires nouveaux obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
FR2584090B1 (fr) 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus
US4719087A (en) * 1985-07-01 1988-01-12 Baxter Travenol Laboratories, Inc. Tray for analyzing system
EP0212807A3 (en) * 1985-07-15 1988-01-07 Imperial Chemical Industries Plc Coloured compound containing a cationic group and a reactive group
JPS6221151A (ja) 1985-07-19 1987-01-29 Matsushita Electric Ind Co Ltd パタ−ン形成方法
DD254998A1 (de) 1985-07-26 1988-03-16 Zeiss Jena Veb Carl Anordnung zur bildlichen darstellung und analyse von fluoreszenzsignalen
EP0232357B1 (en) 1985-08-05 1991-01-30 Rijksuniversiteit Leiden Labelled macromolecules; a process for their preparation and their use for immunological or immunocytochemical assays
JPS6242057A (ja) * 1985-08-19 1987-02-24 Fuji Photo Film Co Ltd 核酸の塩基配列決定のための信号処理方法
EP0213825A3 (en) 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4731335A (en) * 1985-09-13 1988-03-15 Fisher Scientific Company Method for treating thin samples on a surface employing capillary flow
SE450171B (sv) 1985-10-18 1987-06-09 Carl Urban Ungerstedt Anordning for automatisk uppsamling av sma vetskevolymer
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4882269A (en) 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US4637861A (en) * 1985-12-16 1987-01-20 Allied Corporation Stabilized, lipid membrane-based device and method of analysis
EP0232967B1 (en) 1986-01-10 1993-04-28 Amoco Corporation Competitive homogeneous assay
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4758727A (en) 1986-02-12 1988-07-19 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
JPH0685387B2 (ja) 1986-02-14 1994-10-26 株式会社東芝 位置合わせ方法
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
NO870613L (no) 1986-03-05 1987-09-07 Molecular Diagnostics Inc Deteksjon av mikroorganismer i en prŸve inneholdende nukleinsyre.
EP0240729A3 (en) * 1986-03-05 1988-08-24 Fuji Photo Film Co., Ltd. Method of analyzing autoradiograph for determining base sequence of nucleic acid
US4728591A (en) * 1986-03-07 1988-03-01 Trustees Of Boston University Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures
US4925785A (en) 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5310893A (en) 1986-03-31 1994-05-10 Hoffmann-La Roche Inc. Method for HLA DP typing
US4894796A (en) * 1986-03-17 1990-01-16 Westinghouse Electric Corp. Automatic transfer switch with programmable display
US5256549A (en) 1986-03-28 1993-10-26 Chiron Corporation Purification of synthetic oligomers
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US4875169A (en) 1986-04-11 1989-10-17 Iowa State University Research Foundation, Inc. Method for improving the limit of detection in a data signal
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US4846552A (en) 1986-04-16 1989-07-11 The United States Of America As Represented By The Secretary Of The Air Force Method of fabricating high efficiency binary planar optical elements
US4857656A (en) * 1986-05-08 1989-08-15 Sanshin Kagaku Kogyo Co., Ltd. Active esters used for production of esters or amides and process for producing esters or amides
GB8612221D0 (en) * 1986-05-20 1986-06-25 Amersham Int Plc Assaying species in sample
US4811218A (en) 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
US4808508A (en) * 1986-07-01 1989-02-28 Hoechst Celanese Corporation Negative working color proofing process comprising diazo compound and polyvinyl acetal/polyvinyl alcohol/polyvinyl acetate resin
US5171695A (en) 1986-08-06 1992-12-15 Multilyte Limited Determination of analyte concentration using two labelling markers
US4786684A (en) * 1986-08-21 1988-11-22 The Mount Sinai School Of Medicine Of The City University Of New York Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
GB8621337D0 (en) * 1986-09-04 1986-10-15 Agricultural Genetics Co Non-radioactive nucleic acid hybridization probes
DE3631662A1 (de) * 1986-09-17 1988-03-24 Biotechnolog Forschung Gmbh Verfahren zur simultanen synthese mehrerer peptide an fester phase
JPS6384499A (ja) * 1986-09-26 1988-04-15 Toho Yakuhin Kogyo Kk 酵素によるデルタ睡眠誘発ペプチドの製造法
US5021550A (en) 1986-10-07 1991-06-04 Thomas Jefferson University Method for preventing deletion sequences in solid phase synthesis
GB8624637D0 (en) 1986-10-14 1986-11-19 Emi Plc Thorn Electrical device
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4877745A (en) 1986-11-17 1989-10-31 Abbott Laboratories Apparatus and process for reagent fluid dispensing and printing
US5028525A (en) 1986-11-24 1991-07-02 Regents Of The University Of California Method of preparing and applying single stranded DNA probes to double stranded target DNAs in situ
WO1988004777A1 (en) * 1986-12-15 1988-06-30 Ultra Diagnostics Corporation Monomeric phthalocyanine reagents
JPS63167313A (ja) 1986-12-27 1988-07-11 Hitachi Ltd 自動焦点制御方法
JPH0664057B2 (ja) * 1987-01-06 1994-08-22 富士写真フイルム株式会社 オ−トラジオグラフ解析のための信号処理方法
US4762881A (en) * 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US5077085A (en) 1987-03-06 1991-12-31 Schnur Joel M High resolution metal patterning of ultra-thin films on solid substrates
US5079600A (en) * 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
US5037882A (en) 1987-03-11 1991-08-06 Steel Samuel L Synthesis of oligonucleotide analogs
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
US5026773A (en) 1987-03-11 1991-06-25 Samuel Steel Apparatus for a solid phase synthesis of peptide analogs
US4794150A (en) * 1987-03-11 1988-12-27 Samuel Steel Synthesis of peptide analogs
JPS63223557A (ja) 1987-03-13 1988-09-19 Nec Corp 半導体バイオセンサの製造方法
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
NZ224284A (en) * 1987-04-24 1990-11-27 Unilever Plc Porous substrate containing gel for use in chemical synthesis, separation etc
US5100777A (en) 1987-04-27 1992-03-31 Tanox Biosystems, Inc. Antibody matrix device and method for evaluating immune status
US4833332A (en) * 1987-06-12 1989-05-23 E. I. Du Pont De Nemours And Company Scanning fluorescent detection system
SE458968B (sv) 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US4874500A (en) 1987-07-15 1989-10-17 Sri International Microelectrochemical sensor and sensor array
US4921805A (en) 1987-07-29 1990-05-01 Life Technologies, Inc. Nucleic acid capture method
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US5149625A (en) 1987-08-11 1992-09-22 President And Fellows Of Harvard College Multiplex analysis of DNA
CA1321488C (en) * 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
US5011770A (en) 1987-09-04 1991-04-30 Molecular Devices, Inc. DNA detection method
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides
US5006464A (en) 1987-10-01 1991-04-09 E-Y Laboratories, Inc. Directed flow diagnostic device and method
US4981985A (en) 1987-10-20 1991-01-01 Trustees Of The University Of Pennsylvania Synthesis of photolabile chelators for multivalent cations
AU2635088A (en) * 1987-12-04 1989-06-08 Du Pont Merck Pharmaceutical Company, The Immobilized interleukin 2 and interleukin 2 containing a carboxyl-terminal extension
US4886741A (en) * 1987-12-09 1989-12-12 Microprobe Corporation Use of volume exclusion agents for the enhancement of in situ hybridization
CA1335721C (en) * 1987-12-24 1995-05-30 Patrick E. Guire Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces
US4844617A (en) 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
EP0328256A1 (en) * 1988-01-21 1989-08-16 Owens-Corning Fiberglas Corporation Glass fibers coated with agarose for use as column packing or chromatographic media for bioseparations
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
FR2628530B1 (fr) * 1988-03-08 1994-01-28 Chemunex Sa Appareil et procede de detection et de numeration de particules fluorescentes, portees par un support solide
US4946942A (en) * 1988-03-11 1990-08-07 Bioresearch, Inc. Urethane-protected amino acid-N-carboxyanhydrides
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
IL89964A0 (en) 1988-04-15 1989-12-15 Montefiore Med Center Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
ATE173508T1 (de) * 1988-05-20 1998-12-15 Hoffmann La Roche Befestigung von sequenzspezifischen proben
US5013669A (en) 1988-06-01 1991-05-07 Smithkline Diagnostics, Inc. Mass producible biologically active solid phase devices
US5108576A (en) * 1988-06-13 1992-04-28 Ohmicron Corporation Pyroelectric thermometric device
DE3923165A1 (de) 1988-07-15 1990-01-18 Hitachi Ltd Magnetplattenvorrichtung
DE3856430T2 (de) * 1988-07-22 2001-05-03 Surmodics, Inc. Herstellung von polymeren oberflächen
US5281540A (en) * 1988-08-02 1994-01-25 Abbott Laboratories Test array for performing assays
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US4992383A (en) 1988-08-05 1991-02-12 Porton Instruments, Inc. Method for protein and peptide sequencing using derivatized glass supports
US5225326A (en) 1988-08-31 1993-07-06 Research Development Foundation One step in situ hybridization assay
US5206137A (en) 1988-09-08 1993-04-27 Lifecodes Corporation Compositions and methods useful for genetic analysis
DE3880679D1 (de) 1988-09-14 1993-06-03 Siemens Ag Roentgendiagnostikeinrichtung mit einem speicherleucht- schirm.
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
JP2897027B2 (ja) 1988-10-27 1999-05-31 スズキ株式会社 免疫学的凝集反応検出装置
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5869237A (en) 1988-11-15 1999-02-09 Yale University Amplification karyotyping
US5215889A (en) 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5489507A (en) 1988-11-30 1996-02-06 Perkin-Elmer Corporation DNA detection by color complementation
US5047524A (en) 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US4992583A (en) 1989-01-06 1991-02-12 The Goodyear Tire & Rubber Company Process for synthesizing N-chlorothio-sulfonamides
US5077210A (en) 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US4984857A (en) 1989-01-17 1991-01-15 Iowa State University Research Foundation, Inc. Linearization of scan velocity of resonant vibrating-mirror beam deflectors
US4921348A (en) 1989-01-26 1990-05-01 Iowa State University Research Foundation, Inc. Method and means for a spatial and temporal probe for laser-generated plumes based on density gradients
IT1232252B (it) 1989-02-22 1992-01-28 Rotta Research Lab Derivati della n fenil benzamide ad attivita' antiulcera ed antiallerica e procedimento per la loro preparazione
US5081584A (en) 1989-03-13 1992-01-14 United States Of America Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide
EP0392546A3 (en) 1989-04-14 1991-09-11 Ro Institut Za Molekularnu Genetiku I Geneticko Inzenjerstvo Process for determination of a complete or a partial contents of very short sequences in the samples of nucleic acids connected to the discrete particles of microscopic size by hybridization with oligonucleotide probes
US5112962A (en) 1989-04-19 1992-05-12 Northwestern University Labile anchors for solid phase polynucleotide synthesis
US5219726A (en) 1989-06-02 1993-06-15 The Salk Institute For Biological Studies Physical mapping of complex genomes
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6416952B1 (en) * 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
GB2233654A (en) 1989-07-07 1991-01-16 Nat Res Dev Immobilised polynucleotides
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
US5061075A (en) 1989-08-07 1991-10-29 Alfano Robert R Optical method and apparatus for diagnosing human spermatozoa
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5196305A (en) * 1989-09-12 1993-03-23 Eastman Kodak Company Diagnostic and amplification methods using primers having thymine at 3' end to overcome primer-target mismatch at the 3' end
EP0498801B1 (en) * 1989-09-15 1998-11-04 Chiron Mimotopes Pty. Ltd. Solid surface for peptide synthesis
US5232829A (en) 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5297288A (en) * 1989-11-28 1994-03-22 United States Biochemical Corporation System for use with a high resolution scanner for scheduling a sequence of software tools for determining the presence of bands in DNA sequencing samples
US5215882A (en) 1989-11-30 1993-06-01 Ortho Diagnostic Systems, Inc. Method of immobilizing nucleic acid on a solid surface for use in nucleic acid hybridization assays
FI896202A (fi) * 1989-12-22 1991-06-23 Ahlstroem Valmet Metod och anordning vid inloppslaodan av en pappers-, kartong- eller torkmaskin.
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5192407A (en) 1990-01-30 1993-03-09 Iowa State University Research Foundation, Inc. Means and method of detection in chemical separation procedures
US6506558B1 (en) * 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5100626A (en) 1990-05-24 1992-03-31 Levin Andrew E Binding assay device with removable cassette and manifold
GB9014263D0 (en) 1990-06-27 1990-08-15 Dixon Arthur E Apparatus and method for spatially- and spectrally- resolvedmeasurements
GB9015793D0 (en) 1990-07-18 1990-09-05 Medical Res Council Confocal scanning optical microscope
US5306641A (en) 1990-07-27 1994-04-26 Saccocio Edward J Apparatus and method for determining gel rate of polymerizable compositions
US5235028A (en) 1990-08-31 1993-08-10 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5491224A (en) * 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
DE69132843T2 (de) * 1990-12-06 2002-09-12 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Identifizierung von Nukleinsäuren in Proben
EP1046421B8 (en) 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Methods and reagents for very large scale immobilized polymer synthesis
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
US5380489A (en) * 1992-02-18 1995-01-10 Eastman Kodak Company Element and method for nucleic acid amplification and detection using adhered probes
US5198871A (en) 1991-06-18 1993-03-30 Southwest Research Institute Laser-induced-fluorescence inspection of jet fuels
US5491570A (en) * 1991-07-26 1996-02-13 Accuwave Corporation Methods and devices for using photorefractive materials at infrared wavelengths
AU2422492A (en) * 1991-08-07 1993-03-02 H & N Instruments, Inc. Synthesis of chain chemical compounds
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5291763A (en) * 1991-09-18 1994-03-08 Cuisinot Charles P Universal lock for quick release mechanism
US5556961A (en) 1991-11-15 1996-09-17 Foote; Robert S. Nucleosides with 5'-O-photolabile protecting groups
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5667667A (en) 1992-04-24 1997-09-16 Isis Innovation Limited Electrochemical treatment of surfaces
GB9218131D0 (en) 1992-08-26 1992-10-14 Slater James H A method of marking a liquid
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5386221A (en) * 1992-11-02 1995-01-31 Etec Systems, Inc. Laser pattern generation apparatus
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5382512A (en) * 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
US5381224A (en) 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
JPH0772378A (ja) 1993-09-02 1995-03-17 Nikon Corp 合焦装置
JP3488465B2 (ja) 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5727098A (en) * 1994-09-07 1998-03-10 Jacobson; Joseph M. Oscillating fiber optic display and imager
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5776737A (en) 1994-12-22 1998-07-07 Visible Genetics Inc. Method and composition for internal identification of samples
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US5707806A (en) 1995-06-07 1998-01-13 Genzyme Corporation Direct sequence identification of mutations by cleavage- and ligation-associated mutation-specific sequencing
US5777888A (en) 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5698393A (en) 1995-08-18 1997-12-16 Abbott Laboratories Method for elimination of rheumatoid factor interference in diagnostic assays
US5871697A (en) 1995-10-24 1999-02-16 Curagen Corporation Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
WO1999042813A1 (en) * 1998-02-23 1999-08-26 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6346423B1 (en) * 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US6171797B1 (en) * 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays

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