KR20100037637A - Egfr 억제제 치료에 대한 예측 마커 - Google Patents
Egfr 억제제 치료에 대한 예측 마커 Download PDFInfo
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Abstract
본 발명은 암 환자에서 EGFR 억제제 치료의 임상적 이득을 예측하는 바이오마커를 제공한다.
Description
본 발명은 암 환자에서의 EGFR 억제제 치료의 임상적 이득을 예측하는 바이오마커를 제공한다.
다수의 인간 악성종양은 상피 성장 인자 수용체 (EGFR)의 일탈 또는 과발현과 연관되어 있다. EGF, 형질전환 성장 인자 α (TGF-α) 및 다수의 기타 리간드는 EGFR에 결합하여, 수용체의 세포내 타이로신 키나아제 도메인의 자가인산화를 자극한다. 여러 가지 세포내 경로들이 후속하여 활성화되며, 이들 하류방향 사건들은 시험관내 종양 세포 증식을 초래한다. EGFR을 통한 종양 세포의 자극이 생체내 종양 성장 및 종양 생존의 두 가지 모두에 중요하다는 것은 기정사실이다.
EGFR 타이로신 키나아제의 억제제인 TarcevaTM (에를로티니브)를 이용한 초기의 임상 데이터는, 그 화합물이 안전하며, 표적으로 하는 유효 농도를 제공하는 투여량 (전임상 데이터로 결정됨)에서 일반적으로 널리 용인된다는 것을 나타낸다. 진행된 질환이 있던 환자에서의 임상 I상 및 II상 시험은, TarcevaTM가 일정 범위의 상피 종양에서 유망한 임상 활성을 갖는다는 것을 증명했다. 실제로, TarcevaTM가 두경부암이 있는 환자 및 NSCLC (비-소세포 폐암)이 있는 환자에서 기존 확립된 2차 항암치료의 화학요법과 비슷한 정도로 오래가는 부분적인 차도를 유도할 수 있고, 화학요법보다 더 나은 안전성 프로파일 및 개선된 편의성 (정맥내 [i.v.] 투여 대신 정제)의 이득을 추가하는 것으로 나타났다. 최근 완결된, 무작위적인 이중맹검 위약 통제 시험 (BR.21)은, 진행된 질환에 대한 표준 요법이 실패한 NSCLC 환자의 생존을 단일 약제 TarcevaTM가 현저하게 연장시키고 개선시킨다는 것을 나타내었다.
TarcevaTM (에를로티니브)는 소형 화학 분자이다; 이는 경구 활성인, EGFR 타이로신 키나아제 (EGFR-TKI)의 강력하고 선택적인 억제제이다.
폐암은 북미 및 유럽에서 암 관련한 사망의 주된 요인이다. 미국에서, 폐암에 부차적인 사망자 숫자는 암 관련 사망 원인을 주도하여, 두 번째 (대장암), 세 번째 (유방암) 및 네 번째 (전립선암)를 총합한 사망자 수를 능가한다. 전체 폐암의 약 75% 내지 80%가 NSCLC이며, 약 40%의 환자들은 국소적으로 진행되고/되거나 수술로 치유불가능한 질환을 나타내고 있다. 이러한 군에는 일반적으로 악성 흉수를 제외한, 종양의 부피가 큰 병기 (stage)인 IIIA기 및 IIIB기 질환을 갖는 이들이 포함된다.
유럽 연합에서, 매년 폐암의 대략적인 발생률은 100,000명당 52.5명이며, 사망률은 48.7명이다. 남성들 중에서는 상기 비율이 79.3 및 78.3이며, 여성들 중에서는 상기 비율이 각각 21.6 및 20.5이다. NSCLC는 폐암 전체의 80%를 차지한다. 남성 폐암 사망의 약 90% 및 여성 폐암 사망의 80%는 흡연이 원인이다.
US에서, 미국 암 학회에 따르면, 2004년 동안, 약 173,800건의 신규한 폐암 발병 (남성 93,100건 및 여성 80,700건)이 있었으며, 이는 모든 신규한 암 발병의 약 13%를 차지했다. 대부분의 환자들은 진단 후 2년 내에 그 질환의 결과로 사망한다. 다수의 NSCLC 환자에 있어서, 성공적인 치료는 찾기 힘든 것으로 남아있다. 한참 진행된 종양은 종종 수술로도 치료불가능하며, 용인가능한 투여량의 방사선요법 및 화학요법에도 내성이 생길 수 있다. 무작위적인 시험에서, 현재 가장 활발한 병용 화학요법은 약 30% 내지 40%의 종양 반응률을 달성하며, 1년간 생존율은 35% 내지 40%이다. 이는 단독적인 보존적 치료가 보여주는 10%의 1년 생존율을 훨씬 앞선다 (Shepherd 1999).
최근까지, 재발한 환자에 대한 치료 선택폭은 최선의 보존적 치료 또는 일시적 완화로 제한되어 있었다. 도세탁셀 (Taxotere)과 최상의 보존적 치료를 비교한 최근의 시험은, NSCLC가 있는 환자가, 시스플라틴 기반의 1차 항암치료의 식이요법이 실패한 후, 2차 항암치료의 화학요법으로 이득을 볼 수 있다는 것을 보여주었다. 모든 연령대의, ECOG 성능 상태 (performance status)가 0, 1 또는 2인 환자에서, 먼저 했던 백금-기반의 치료로는 치료가 어려웠던 이들에서처럼, 도세탁셀의 이용으로 생존이 개선되었음이 증명되었다. 요법으로 이득을 못 본 환자들에는, 10%의 체중 손실이 있거나, 락테이트 디하이드로게나아제 수준이 높거나, 여러 장기에 연루되어 있거나 또는 간에 연루되어 있는 이들이 포함된다. 추가적으로, 도세탁셀 단독요법의 이득은 2차 항암치료 설정을 넘어서진 못했다. 3차 이상의 항암치료로서 도세탁셀을 받은 환자들은 생존의 연장을 보여주지 않았다. 단일 약제 도세탁셀은 NSCLC에 대한 표준 2차 항암치료 요법이 되었다. 최근, NSCLC의 2차 항암치료 요법에서 또 다른 무작위적인 III상 시험에서는 페메트렉세드 (Alimta)와 도세탁셀을 비교하였다. 페메트렉세드를 이용한 치료는 임상적으로 동등한 효능을 도출했으나, 도세탁셀보다 훨씬 더 적은 부작용이 있었다.
맞춤화된 암 치료 방법 개발에 대한 필요가 있음은 오래 전부터 인정되어 왔다. 표적으로 삼은 암 치료법을 개발하면서, 종양 표적의 분자적 프로파일을 제공할 수 있는 방법론 (즉, 임상적인 이득에 대해 예측되는 것)이 특별한 관심대상이 되었다. 암에서의 유전자 발현 프로파일에 대한 법칙의 증거는, 현재의 형태학적 및 면역세포화학적 시험을 근거로 하기에는 명확하지 않은 종양 유형의 분자적 분류를 이용하여 이미 확립되어 있다. 두 개별적 질환 주체는, 유전자 발현 프로파일링을 사용하여 미만성 대세포 B-세포 림프종의 단일한 현 분류로부터 상이한 예측으로 분화되었다.
그러므로, 암 환자에서 EGFR 억제제 치료의 임상적 이득을 예측하는 발현 바이오마커를 제공하는 것이 본 발명의 목표이다.
본 발명의 첫 번째 목적에서는, EGFR 억제제를 사용한 치료에 대해 반응하는 환자의 임상적 이득을 예측하는 시험관내 방법이 제공된다. 상기 방법은 하기 단계를 포함한다: 환자의 종양 샘플에서의 표 3으로부터 선택된 하나 이상의 유전자의 발현 수준을 측정하고, 하나 이상의 유전자의 발현 수준을, 치료로부터 임상적 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값에 대해 비교하는 단계 (여기서 환자의 종양 샘플에서의 하나 이상의 유전자의 차등 발현 수준은 치료로부터 임상적 이득을 얻을 환자에 대한 표식임).
용어 "치료로부터 임상적 이득을 얻지 못하는 환자 집단의 종양에서의 하나 이상의 마커 유전자의 발현 수준의 대표값"은 치료로부터 임상적 이득을 얻지 못하는 환자 집단의 종양에서의 마커 유전자의 평균 발현 수준에 대한 계산치를 나타낸다. 임상적 이득은 12주 이상 동안 목적된 반응 또는 질환 안정화를 갖는 것으로서 정의된다.
추가적인 바람직한 구현예에서, 둘 이상의 유전자의 발현 수준이 측정된다.
또 다른 바람직한 구현예에서, 셋 이상의 유전자의 발현 수준이 측정된다.
추가적인 바람직한 구현예에서, 유전자는 ATP6V0E1, MAPRE1, PSMA5, ACSL3, RAP1A, SLC2A3, CHMP2B, RFK, CTGF, HSPA8, AKAP12, LOX, SLMO2, NOMO3, APOO로 이루어지는 군에서 선택되며, 상기 유전자는 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 낮은 발현 수준을 나타낸다.
추가적인 바람직한 구현예에서, 유전자는 SDC1, CEBPA, ST6GALNAC2, PLA2G6, PMS2L11, C19orf7, DDX17, SFPQ, PMS2L3, SLC35E2, PMSL2, URG4, PPP1R13B, NRCAM, FLJ10916, FLJ13197, GPR172B, ZNF506, ARHGAP8, CELSR1, LYK5로 이루어지는 군에서 선택되며, 상기 유전자는 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 높은 발현 수준을 나타낸다.
바람직한 구현예에서, 하나 이상의 유전자의 발현 수준은 마이크로어레이 (microarray) 기술로 측정된다. 유전자칩의 구축 및 사용은 당업계에 널리 공지되어 있다. U.S. 특허 제 5,202,231 호; 제 5,445,934 호; 제 5,525,464 호; 제 5,695,940 호; 제 5,744,305 호; 제 5,795,716 호 및 제 5,800,992 호를 참조한다. 또한, Johnston, M. Curr. Biol. 8:R171-174 (1998); Iyer VR 등, Science 283:83-87 (1999)을 참조한다. 물론, 유전자 발현 수준은 당업자에게 공지된 기타 방법, 예를 들어 노던 블롯, RT-PCR, 실시간 정량 PCR, 프라이머 신장, RNase 보호, RNA 발현 프로파일링으로 측정될 수 있다.
본 발명의 유전자는 바이오마커 집합으로 조합될 수 있다. 바이오마커 집합은, 암 환자에서의 EGFR 억제제 치료의 효과에 대한 예측을 위해 표 3에 열거된 바이오마커의 임의 조합으로부터 성립될 수 있다. 본원에서 기재된 다양한 바이오마커 및 바이오마커 집합이, 예를 들어, EGFR 억제제를 사용한 치료적 개입에 대해 암 환자가 어떻게 반응할 것인지를 예측하는데 사용될 수 있다.
본원에서 사용되는 바와 같은 "유전자"라는 용어는 유전자의 변이체를 포함한다. "변이체"라는 용어는 GenBank 접근 번호로 주어진 핵산 서열과 실질적으로 유사한 핵산 서열에 관한 것이다. "실질적으로 유사한"이라는 용어는 당업자에게는 잘 이해된다. 특히, 유전자 변이체는 인간 집단 내에서 가장 우세한 대립형질의 핵산 서열과 비교하여 뉴클레오티드 교환을 보이는 대립형질일 수 있다. 바람직하게는, 이러한 실질적으로 유사한 핵산 서열은 80% 이상, 바람직하게는 85% 이상, 보다 바람직하게는 90% 이상, 가장 바람직하게는 95% 이상의 가장 우세한 대립형질과의 서열 유사성을 갖는다. "변이체"라는 용어는 또한 스플라이스 (splice) 변이체에 관한 것을 의미한다.
EGFR 억제제는 게피티니브, 에를로티니브, PKI-166, EKB-569, GW2016, CI-1033 및 항-erbB 항체, 예컨대 트라스투주마브 및 세툭시마브로 이루어진 군으로부터 선택될 수 있다.
또 다른 구현예에서, EGFR 억제제는 에를로티니브이다.
또 다른 구현예에서, 암은 NSCLC이다.
본 발명에 의해 기재되는 유전자의 유전자 발현의 검출 기술에는 노던 블롯, RT-PCR, 실시간 정량 PCR, 프라이머 확장, RNase 보호, RNA 발현 프로파일링 및 관련 기술이 포함되나 이에 제한되는 것은 아니다. 이러한 기술은 당업자에게 잘 알려져 있으며, 예를 들어 [Sambrook J 등, Molecular Cloning: A Laboratory Manual, Third Edition (Cold Spring Harbor Press, Cold Spring Harbor, 2000)]를 참조한다.
본 발명에 의해 기재되는 각 유전자의 단백질 발현 검출 기술에는 면역조직화학 (IHC; Immunohistochemistry)이 포함되나 이에 제한되는 것은 아니다.
본 발명에 따르면, 종양 또는 암 생검과 같은 환자 조직 샘플로부터의 세포를 검정하여, 하나 이상의 바이오마커의 발현 패턴을 측정할 수 있다. 암 치료의 성공 또는 실패는, 종양 또는 암 생검과 같은 시험 조직으로부터의 세포 (시험 세포)의 바이오마커 발현 패턴이, 하나 이상의 바이오마커의 대조군 집합의 발현 패턴과 비교적 유사 또는 상이한가에 근거해 결정될 수 있다. 본 발명의 문맥에서, EGFR 억제제 치료로부터 임상적 이득을 얻지 못한 환자의 종양과 비교하여 EGFR 억제제 치료로부터 임상적 이득을 얻은 환자의 종양에서, 표 3에 열거한 유전자가 차등적으로 발현된다는, 즉 보다 높은 또는 낮은 발현 수준을 보인다는 것을 발견하였다. 따라서, 시험 세포가 암 치료에 반응하였던 환자의 바이오마커 발현 프로파일에 상응하는 바이오마커 발현 프로파일을 보이는 경우, 개체의 암 또는 종양이 EGFR 억제제를 사용한 치료에 바람직하게 반응할 것 같거나 그러할 것으로 예상된다. 반대로, 시험 세포가 암 치료에 반응하지 않았던 환자의 바이오마커 발현 패턴에 상응하는 바이오마커 발현 패턴을 보이는 경우, 개체의 암 또는 종양이 EGFR 억제제를 사용한 치료에 바람직하게 반응하지 않을 것 같거나 그러할 것으로 예상된다.
본 발명의 바이오마커, 즉 표 3에 열거된 유전자는 암 환자, 특히 불응성 NSCLC 환자에 대한 맞춤 요법 (individualized therapy)을 향한 첫 번째 단계이다. 상기 맞춤 요법은 진료 의사가 암 치료요법, 특히 NSCLC에 대한 기존의 약물들 중 가장 적절한 제제를 선별할 수 있게 할 것이다. 각각의 미래의 환자에 대한 맞춤 요법의 이득은 하기와 같다: 반응률 / 이득을 얻는 환자의 수가 증가하고 비효과적인 치료로 인한 유해한 부작용의 위험성이 감소할 것이다.
본 발명의 추가 목적에서는 본 발명의 시험관내 방법에 의해 확인된 암 환자를 치료하는 치료 방법을 제공한다. 상기 치료 방법은 표 3에 열거된 유전자 중 하나 이상의 예측 발현 패턴에 근거해 치료하기로 선택된 환자에게 EGFR 억제제를 투여하는 것을 포함한다. 바람직한 EGFR 억제제는 에를로티니브이고, 치료하고자 하는 바람직한 암은 NSCLC이다.
도 1은 연구 설계를 보여준다;
도 2는 샘플 처리에 대한 도식을 보여준다;
도 2는 샘플 처리에 대한 도식을 보여준다;
실험적 부분
연구에 대한 근거 및
연구 설계
최근 NSCLC 환자의 하위집합의 종양 조직 내의 EGFR 유전자에서의 돌연변이 및, 에를로티니브 및 게피티니브에 대한 감수성을 가진 이러한 돌연변이의 연관성이 기재되어 있다 (Pao W, 등. 2004; Lynch 등. 2004; Paez 등. 2004). 2가지 연구를 조합한 경우 환자에서, 돌연변이된 EGFR은 게피티니브에 반응을 보였던 환자 14명 중 13명에서 관찰되었고, 반응을 보이지 않았던 11명의 게피티니브-처리된 환자에서는 관찰되지 않았다. 이들 돌연변이의 보고된 유병률은 미선별된 NSCLC 환자 중 8% (25명 중 2명)에 달했다. 이들 돌연변이는 선암 (21%), 여성으로부터의 종양 (20%), 및 일본인 환자로부터의 종양 (26%)에서 보다 자주 발견되었다. 이들 돌연변이는 EGFR의 시험관내 활성 증가 및 게피티니브에 대한 감수성 증가를 야기하였다. 돌연변이와 장기적으로 안정된 질환 또는 생존 기간과의 관계는 유망하게 평가되지는 않았다.
BR.21 연구로부터의 예비 분석에 근거하여, 심지어 목적하는 반응을 보이는 환자를 분석에서 제외시킨 경우에도 유의한 생존 이득이 유지되기 때문에 (자료에 근거함), 관찰되는 생존 이득은 EGFR 돌연변이로 인한 것만은 아닌 것으로 보인다. 기타 분자 메커니즘도 또한 효과에 기여하는 것이 분명하다.
TarcevaTM 치료에 대한 반응/이득을 예측하는 유전자 발현 수준의 변화가 있다는 가정에 근거하여, 마이크로어레이 분석을 사용하여 이들 변화를 측정하였다.
이를 위해서는 1차 요법의 실패 후 TarcevaTM 단일요법으로 치료된 명확하게 정의된 연구 집단이 필요하였다. BR.21 연구로부터의 경험에 근거하여, 이득을 얻은 집단을 목적하는 반응, 또는 12주 동안의 질환 안정화를 가진 것으로서 정의하였다. 임상 및 마이크로어레이 데이터 집합을 사전 정의된 통계 계획에 따라 분석하였다.
이 기술을 적용하기 위해서는 신선한 동결 조직 (FFT; fresh frozen tissue)이 필요하다. 그러므로, 처리 시작 전에 의무적인 생검을 수행해야만 한다. 수집된 물질을 액체 질소 (N2)에서 동결시켰다.
동시에 두 번째 종양 샘플을 수집하고, 파라핀에 저장하였다 (포르말린 고정 파라핀 포매: FFPE; formalin fixed paraffin embedded). 상기 샘플을 EGFR 신호 경로에서의 변경에 대해 분석하였다.
기관지경술을 통한 종양 생검을 실시하는 역량이 본 연구를 위한 전제 조건이었다. 기관지경술은 폐암 진단을 확인하기 위한 표준 절차이다. 일반적으로 안전하지만, 출혈과 같은 합병증의 위험이 남아있다.
본 연구는 난치성 NSCLC를 갖는 환자들에 대한 맞춤 요법을 향한 첫 단계였다. 상기 맞춤 요법은 진료 의사가 상기 징후에 대해 기존의 약물들 중 가장 적절한 제제를 선별할 수 있게 할 것이다.
일단 맞춤 요법이 가능해지면, 미래의 각 환자에 대한 이득은 현재의 연구에서 환자들이 감수해야 하는 위험을 능가할 것이다:
반응률 / 이득을 얻는 환자의 수가 증가할 것이고,
비효과적인 치료로 인한 유해한 부작용의 위험성이 감소할 것이다.
투여량 선택에 대한 근거
TarcevaTM를 질환 진행, 용인불가한 독성 또는 사망시까지 150 mg의 투여량으로 1일 1회 경구 투여하였다. 상기 투여량에 대한 선택은 약동학적 변수 뿐 아니라 사전-치료를 과도히 받은 진행된 암 환자들에서 제 I, II 및 III상 시험에서 관찰된 상기 투여량의 안전성 및 내약성 프로파일을 근거로 하였다. 150 mg/일 투여량을 받은 암 환자들의 혈장에서 나타난 약물 수준은 임상적 효능을 목적으로 하는 500 ng/ml의 평균 혈장 농도보다 높은 수준으로 일정했다. BR.21은, 상기 투여량으로 생존 이득을 보여주었다.
상기 연구의 목적
이의 일차적 목적은 TarcevaTM 치료의 임상적 이득 (CR, PR 또는 SD ≥ 12주)을 예측하는 차등 발현 유전자들을 확인하는 것이었다. TarcevaTM 치료에 대한 "반응" (CR, PR)을 예측하는 차등 발현 유전자들의 확인은 중요한 추가적인 목적이었다.
부차적인 목적은, 치료를 통한 이득에 관해서, EGFR 신호전달 경로에서의 변경을 평가하는 것이었다.
연구 설계
연구 설계 및 투여 방법에 대한 개관
이는 공개 (open-label) 예측 마커 확인 제 II상 연구였다. 본 연구는 약 12개국의 대략 26개 지역에서 수행되었다. 1가지 이상의 사전 화학요법이 실패한 진행성 NSCLC를 가진 264명의 환자가 12개월의 기간에 걸쳐 등록하였다. 지속적으로 경구 TarcevaTM가 150 mg/일의 투여량으로 투여되었다. 약물 요법에 대한 내약성에 근거하여 투여량 감소가 허용되었다. 질환 조절 및 독성을 평가하기 위해 임상 및 실험 매개변수들을 검토 평가하였다. 치료는 질환 진행, 허용불가능한 독성 또는 사망시까지 계속되었다. 당해 연구 설계를 도 1에 나타내었다.
분자적 분석을 위해 종양 조직 및 혈액 샘플을 수득하여, TarcevaTM의 효과를 평가하고 치료를 통해 이득을 얻는 환자들의 하위군을 확인하였다.
예측
마커
평가
종양 생검은 치료 시작 전 2주 내에 취하였다. 하기 2가지의 상이한 샘플을 채취하였다:
첫 번째 샘플은 항상 액체 N2 중에 즉시 동결시켰다.
두 번째 샘플은 포르말린 중에 고정시킨 후 파라핀 중에 포매시켰다.
즉시 동결 조직은 본 연구에서 가장 높은 우선순위를 가졌다.
도 2는 샘플 처리에 대한 도식을 나타낸다.
마이크로어레이
분석
종양 RNA 및 종양 주변 조직으로부터의 RNA를 추출하기 위한 종양 세포의 레이저 포획 미세절제 (laser capture microdissection; LCM)에 상기 즉시 동결 샘플을 사용하였다. 상기 RNA를 Affymetrix 마이크로어레이 칩 (HG-U133A) 상에서 분석하여 상기 환자들의 종양 유전자 발현 프로파일을 확립하였다. Affymetrix 칩에 대한 품질 관리를 사용하여 통계학적 비교를 위한 적절한 품질의 샘플을 선택하였다.
포르말린 고정된 파라핀
포매
조직에 대한 단일
바이오마커
분석
상기 두 번째 종양 생검인 FFPE 샘플을 사용하여, DNA 돌연변이, IHC 및 ISH 분석을 하기 기재한 바와 같이 수행하였다. 초기 진단시 수집된 조직에 대해서도 유사한 분석을 수행하였다.
EGFR 및 EGFR 신호전달 경로에 관여하는 기타 분자를 인코딩하는 유전자의 DNA 돌연변이 상태를 DNA 서열분석으로써 분석하였다. EGFR 및 관련 유전자들의 유전자 증폭은 FISH로 연구되었다.
단백질 발현 분석에는 EGFR 및 EGFR 신호전달 경로 내에서의 기타 단백질의 면역조직화학 [IHC] 분석이 포함되었다.
반응 평가
RECIST (Uni-dimensional Tumour Measurement) 기준을 사용하여 반응을 평가하였다. 상기 기준은 하기 링크에서 찾아볼 수 있다: http://www.eortc.be/recist/
다음을 주의해야 한다: CR 또는 PR의 상태로 규정하기 위해서는, 상기 치료 기간 중의 임의의 시점과는 적어도 4주 떨어진 시점에서의 반복 평가에 의해 종양 측정치의 변화가 확인되어야 한다.
SD의 경우, 후속적인 측정치가 연구 시작 후 최소 6주의 간격으로 적어도 1회 SD 기준을 충족해야 한다.
SD 유지의 경우, 후속적인 측정치가 연구 시작 후 12주 이상의 지속 시간에 걸쳐 적어도 1회 SD 기준을 충족해야 한다.
생존 평가
환자가 진료소로 방문하거나 또는 전화에 의해 3개월마다 정기적인 상태 체크를 수행하였다. 모든 사망을 기록하였다. 연구의 말미에는 각 환자에 대해 최종적 생존 확인이 필요하였다.
방법
RNA
샘플 제조 및
RNA
샘플에 대한 품질 관리
모든 생검 샘플 처리는 병리학 표준 실험실에서 다루어졌고; 새로 동결된 조직 샘플은 조사기관 지역에서 Roche Basel의 임상 샘플 작업 (Clinical Sample Operations) 시설로 수송되었고, 추가적인 처리를 위해 거기에서 병리학 실험실로 수송되었다. 레이저 포획 미세절제를 사용하여 주변 조직으로부터 종양 세포를 선별하였다.
LCM 후, 상기 종양 풍부 물질로부터 RNA를 정제하였다. 상기 병리학 실험실은 그 후 상기 RNA의 농도 및 품질에 대한 추정을 위한 일련의 단계를 실행하였다.
RNase는 RNA 분해 효소이며 도처에서 발견되고, 따라서 RNA가 사용될 모든 절차는 RNA 분해를 최소화하도록 엄격히 조절되어야만 한다. 대부분의 mRNA 종은 자체적으로 다소 짧은 반감기를 가지며, 따라서 상당히 불안정한 것으로 간주된다. 그러므로, 임의 검정 전에 RNA 보전성 체크 및 정량화를 수행하는 것이 중요하다.
RNA 농도 및 품질 프로파일은 2100 Bioanalyzer로 불리는 Agilent 기기 (Agilent Technologies, Inc., Palo Alto, CA)를 사용하여 평가될 수 있다. 기기 소프트웨어는 RNA 보전성 번호 (RIN), 정량화 추정 (Schroeder, A., 등, The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol, 2006. 7: p.3)을 생성하고, 총 RNA 샘플의 리보솜 비율을 계산한다. RIN은 RNA 샘플의 전체 전기영동적 추적으로부터 측정되며, 이에는 분해 생성물의 존재 또는 부재가 포함된다.
RNA 품질을 2100 Bioanalyzer로 분석하였다. Affymetrix 플랫폼 상에서의 추가적 분석을 위해, 충분한 RNA 및 첨가된 폴리-I 노이즈 초과의 하나 이상의 rRNA 피크를 갖는 샘플만을 선택하였다. 마이크로어레이에 의한 분석을 위해, 정제된 RNA를 로셰 의학 게놈학 센터 {Roche Centre for Medical Genomics (RCMG; Basel, Switzerland)}로 보냈다. 추가적인 처리를 위해 병리학 실험실로부터 122개 RNA 샘플을 받았다.
조직
RNA
샘플의 표적 표지
제조사의 지시사항에 따른 것으로서, Affymetrix로부터의 2-사이클 표적 표지 증폭 프로토콜 (Affymetrix, Santa Clara, California)에 따라 표적 표지를 실행하였다.
상기 방법은 표준 에버와인 선형 증폭 방법을 기준으로 하지만, 마이크로어레이에 대한 하이브리드화를 위해 충분히 표지된 cRNA가 생성되도록 상기 방법의 두 사이클을 사용한다.
표지 반응에서 사용된 총 RNA 투입량은, 10 ng 초과의 RNA가 활용가능한 경우 이들 샘플에 대해 10 ng 이었고; 상기 양 미만이 활용가능하거나 또는 활용가능한 양 데이터가 없는 경우 (매우 낮은 RNA 농도로 인해), 총 샘플의 절반을 반응에 사용하였다. 표지 반응으로부터의 수율은 20 ~ 180 μg cRNA이었다. 15 μg cRNA가 모든 샘플에 대해 사용된 하이브리드화의 수준에서 표준화 단계를 도입하였다.
인간 참조 RNA (Stratagene, Carlsbad, CA, USA)를, 샘플 각각의 뱃치 (batch)로의 작업량 내에서 대조군 샘플로서 사용하였다. 10 ng의 상기 RNA를 시험 샘플과 함께 투입으로서 사용하여, 표지 및 하이브리드화 시약이 예측한 바와 같이 작용하는지 확인하였다.
마이크로어레이
하이브리드화
Affymetrix HG-U133A 마이크로어레이는 약 14,500개의 잘 분석된 유전자를 나타내는 약 18,400개의 전사체 및 변이체를 표적하는 22,000개 초과의 프로브 집합을 포함한다.
Affymetrix 지시사항 (Affymetrix Inc., Expression Analysis Technical Manual, 2004)에 따라 모든 샘플에 대한 하이브리드화를 실행하였다. 간략하게는, 각각의 샘플에 대해, 15 μg의 바이오틴-표지된 cRNA를 2가 양이온의 존재 하 및 가열 하에 절편화하고, Affymetrix HG-U133A 전체 게놈 올리고뉴클레오티드 어레이에서 하룻밤 동안 하이브리드화하였다. 다음날 어레이를 제조사의 지시사항에 따라 스트렙타비딘-피코에리트린 (Molecular Probes; Eugene, OR)으로 염색하였다. 이후 GeneChip Scanner 3000 (Affymetrix)을 사용하여 어레이를 스캐닝하고, GeneChip Operating Software (GCOS) 버전 1.4 (Affymetrix)로 신호 세기를 자동으로 계산하였다.
통계적 분석
AffymetrixTM 데이터의 분석은 5개 주요 단계로 구성되었다.
단계 1은 품질 관리였다. 목표는 하위-표준 품질 프로파일을 갖는 어레이 데이터를 확인하고 분석에서 제외시키는 것이었다.
단계 2는 예비-처리 및 표준화였다. 목표는 칩 간 비교되어야 할 표준화 및 스케일화된 "분석 데이터 집합"을 생성하는 것이었다. 이는 배경 노이즈 추정 및 감산, 프로브 요약 및 스케일링을 포함하였다.
단계 3은 탐색 및 설명이었다. 목표는 가변성의 공급원 및 잠재적 경향을 확인하는 것이었다. 이는 다변 및 단변 설명적 분석 기술을 적용하여 유력한 공변 (covariate)을 확인하는 것으로 이루어졌다.
단계 4는 모델링 및 시험이었다. 목표는 "임상적 이득" 및 "임상적 무이득" 환자 사이의 평균 발현 수준에서의 차이의 통계적 평가를 기준으로 후보 마커의 목록을 확인하는 것이었다. 이는 각각의 프로브-집합에 대해 적당한 통계적 모델을 맞추고 통계적 유의성의 측정을 추론하는 것으로 이루어졌다.
단계 5는 견고성 (robustness) 분석이었다. 목표는 예비-처리 방법 및 통계적 가정에 많이 의존하지 않는 후보 마커의 적격 목록을 생성하는 것이었다. 이는 상이한 방법론적 접근으로 분석을 반복하고, 후보 목록을 교차시키는 것으로 이루어졌다. R 소프트웨어 패키지를 사용하여 모든 분석을 수행하였다.
단계 1: 품질 관리
데이터 품질의 평가는 여러 매개변수의 체크를 기준으로 하였다. 이들에는 표준 Affymetrix GeneChipTM 품질 매개변수, 특히 스케일링 인자, 현존 호출 % (Percentage of Present Call) 및 평균 배경이 포함된다. 이러한 단계에는 또한 국지적 하이브리드화 문제점을 검출하기 위한 가상 칩 영상의 시각적 검사, 중간 거동으로부터의 임의 비정상적 이탈을 검출하기 위한, 가상 중간 칩에 대한 각각의 칩의 비교가 포함된다. 칩 간 상관관계 분석을 또한 수행하여 특이점 (outlier) 샘플을 검출하였다. 또한, Agilent BioanalyzerTM 2100으로 RNA 샘플을 분석하여 수득한 RNA 품질의 부수적 측정을 고려하였다.
이들 매개변수를 기준으로, 20개 어레이로부터의 데이터를 분석에서 제외시켰다. 따라서 102명 환자를 나타내는 총 102개 어레이로부터의 데이터를 분석에 포함시켰다. 이들 102개 샘플 집합의 임상적 설명을 하기 표 1에 나타내었다.
분석에 포함된 환자의 임상적 특징 설명 | ||
변수 | 값 | n = 102 |
n (%) | ||
최상의 반응 | N/A | 16 (15.7%) |
PD | 49 (48.0%) | |
SD | 31 (30.4%) | |
PR | 6 (5.9%) | |
임상적 이득 | 없음 | 81 (79.4%) |
있음 | 21 (20.6%) | |
성별 | 여성 | 25 (24.5%) |
남성 | 77 (74.5%) | |
인종 | 백인 | 65 (63.7%) |
동양인 | 37 (36.3%) | |
조직학 | 선암 | 35 (34.3%) |
편평 | 53 (52.0%) | |
기타 | 14 (13.7%) | |
흡연 경험 | 없음 | 20 (19.6%) |
있음 | 82 (80.4%) |
단계 2: 데이터 예비-처리 및 표준화
rma 알고리즘 (Irizarry, R.A., 등, Summaries of Affymetrix GeneChip probe level data. Nucl. Acids Res., 2003. 31(4): p. e15)을 예비-처리 및 표준화에 사용하였다. mas5 알고리즘 (AFFYMETRIX, GeneChip Expression: Data Analysis Fundamentals. 2004, AFFYMETRIX)을, 개별적 프로브-집합에 대한 검출 호출을 만드는데 사용하였다. 모든 샘플에서의 "부재" 또는 "최저한 (marginal)"이라 칭하는 프로브-집합을 추가적 분석에서 제거하고; 5930개 프로브-집합을 상기 기준을 근거로 분석에서 제거하였다. 그러므로 분석 데이터 집합은 102명 환자에서 측정된 16353개 (22283개 중) 프로브-집합을 갖는 매트릭스로 이루어졌다.
단계 3: 데이터 설명 및 탐색
설명적 탐색 분석 (Descriptive exploratory analysis)을 수행하여 가변성의 주요 공급원 및 잠재적 경향을 확인하였다. 유전자 발현 프로파일에 대해 잠재적 영향을 갖는 공변 집합을 스크리닝하였다. 이는 기술적 및 임상적 변수를 모두 포함하였다. 기술적 공변에는 하기가 포함된다: RNA 처리 일자 (이후 뱃치로서 지칭됨), RIN (Schroeder, A., 등, The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol, 2006. 7: p. 3) (RNA 품질/보전성의 측정으로서), 조작자 및 샘플 채취 센터. 임상적 공변에는 하기가 포함된다: 조직학 유형, 흡연 상태, 종양 등급, 성능 점수 (Oken, M.M., 등, Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol, 1982. 5(6): p. 649-55), 인구 통계학적 데이터, 반응자 상태 및 임상적 이득 상태.
분석 도구에는 단변 ANOVA 및 주요 성분 분석이 포함된다. 각각의 공변에 대해, 단변 ANOVA를 각각의 프로브-집합에 대해 독립적으로 적용하였다.
뱃치 변수의 유의한 효과가 확인되었다. 실제로, 뱃치 변수는 샘플 처리 일자와 Affymetrix 칩 롯트 (lot)의 일자 사이의 차이를 포착하였다. 뱃치 변수가 관심 변수와 거의 독립적인 것을 체크한 후, [Johnson, W.E., C. Li, 및 A. Rabinovic, Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostat, 2007. 8(1): p. 118-127]에 기재된 방법을 사용하여 뱃치 영향을 정정하였다.
뱃치 영향 정정 후 표준화된 데이터 집합은 후속 분석에서 분석 데이터 집합으로서 역할하였다.
조직학 및 RIN은 설명적 분석에 의해 강조된 두 추가적인 중요한 변수였다.
단계 4: 데이터
모델링
및 시험
선형 모델을 각각의 프로브-집합에 대해 독립적으로 맞추었다. 모델에 포함되는 변수를 표 2에 나타내었다. 최우 추정법 기술 (maximum likelihood technique)로 모델 매개변수를 추정하였다. "임상적 이득" 변수 (X1)에 상응하는 매개변수를 사용하여 임상적 이득을 갖는 환자군과 임상적 이득이 없는 환자군 사이의 발현 수준 차이를 평가하였다.
선형 모델에 포함된 변수의 설명 | ||
변수 | 유형 | 값 |
유전자 발현 | 의존적 (Yip) | 환자 p에서의 프로브-집합 i의 log2 세기 |
절편 | 전체 평균 (μ) | |
임상적 이득 | 관심 예측자 (X1) | 있음/없음 |
조직학 | 조정 공변 (X2) | 선암/편평/기타 |
인종 | 조정 공변 (X3) | 동양인/백인 |
성별 | 조정 공변 (X4) | 여성/남성 |
RIN | 조정 공변 (X5) | [2,...,7.9] |
흡연자 | 조정 공변 (X6) | 현재/과거/무경험 |
병기 | 조정 공변 (X7) | 비절제.III/IV |
각각의 프로브-집합 i에 대해, 통계적 시험의 목표는, 표 2에 열거한 기타 조정 공변을 고려하여, 임상적 이득을 갖는 환자 및 임상적 이득을 갖지 못한 환자에서의 평균 발현 수준이 동등하다는 가설을 거부하는 것이었다. 공식적으로, 동등성의 무효적 가설을 두 측면의 대안에 대해 시험하였다. 상응하는 p-값을 표 3에 나타내었다.
두 가지 이유에 의해 선형 모델의 선택이 유발되었다. 첫째로, 선형 모델은 다목적적이며, 잘 분석되고 견고성 접근적이어서, 관심 변수의 영향을 추정하는 경우 혼동 변수가 조정되도록 한다. 둘째로, 샘플 크기 102가 주어지고, 데이터 집합의 표준화 및 스케일링, 정상 분포 가정이 합리적이고 정당하였다.
각각의 프로브-집합에 대해, 잔류 모델을 기준으로 플리그너-킬린 (Fligner-Killeen) 시험을 사용하여 변동의 동질성 가정을 추정하였다. 분석은 하기 3개 단계로 이루어졌다:
1. 잔류 변수의 동질성에 대해 각각의 분류별 변수를 시험하는 단계,
2. 최소 p-값을 갖는 변수 V에 주의하는 단계, 및
3. 최소 p-값이 0.001 미만인 경우, 상이한 수준의 변수 V가 상이한 변동을 갖도록 모델을 다시 맞추는 단계.
단계 5: 견고성
견고성 분석의 목표는 예비-처리 단계 또는 통계적 분석의 기초가 되는 가정의 결과로서 분석 결과가 인위적일 수 있는 위험성을 감소시키는 것이었다. 하기의 세 가지 측면이 고려되었다: a) 품질 관리 단계에서의 몇몇 여분의 칩의 포함 또는 제외; b) 예비-처리 및 표준화 알고리즘; c) 통계적 가정 및 시험 접근.
상이한 분석 설정을 갖는 유의함으로서 일관적으로 표명된 유전자의 하위집합으로서 후보 마커의 목록을 정의하였다. 상이한, 적용된 분석 옵션은 하기와 같다:
a) 보다 엄격한 품질 관리 기준을 근거로 8개 칩의 추가적인 하위집합을 확인하였다. 이들 8개 칩을 제외시킴으로써 "감소된 데이터 집합"을 정의하였다.
b) 예비-처리 및 표준화용 rma에 대한 대안물로서 MAS5를 확인하였다. MAS5는 배경 추정, 프로브 요약 및 표준화에 대해 상이한 방법을 사용한다.
c) 하기 2가지의 추가적인 통계학적 시험을 사용하였다. 이들 두 추가적인 시험은 기초가 되는 통계적 가정의 상이한 집합에 의지한다.
a. 임상적 이득ㆍ임상적 무이득 사이의 차이에 대한 윌콕슨 (wilcoxon) 시험 및
b. 응답 변수로서 임상적 이득을 취하고 공변으로서 유전자 발현을 취하는 로지스틱 회귀 (logistic regression) 모델을 시험하는 우도비 시험 (LRT; likelihood ratio test). 각각의 프로브-집합에 있어서, LRT는 1 자유도의 카이-제곱을 따랐다.
요약하면, 2가지 집합의 샘플 ("풀 (full)" 데이터-집합 및 "감소된 (reduced)" 데이터-집합), 및 2가지의 예비-처리된 알고리즘 (mas5 및 rma)이 고려되었다; 이는 4가지의 상이한 분석 데이터 집합을 산출하였다. 상기 4가지의 데이터 집합 각각에, 3가지의 상이한 통계학적 시험을 적용하였다. 그러므로, 각 프로브-집합에 대해, 3가지 p-값을 계산하였다. 각각의 분석 데이터 집합에서, 복합 기준을 적용하여, 차등적으로 조절되는 유전자 목록을 확인하였다. 상기 기준을 다음과 같이 정의하였다: 최대 p-값은 0.05 미만이고, p-값의 기하 평균은 0.01 미만이다.
마커 유전자를 확인하기 위해 기준 2를 사용하는 견고성 분석으로 36개 상이한 유전자에 상응하는 36개 프로브-집합의 목록이 야기되었다. 이들 마커를 표 3에 열거하였다.
표 3: 복합 기준 적용 후 견고성 분석에 근거한 임상적 이득에 대한 유전자 마커.
제 1열은 프로브-집합의 Affymetrix 확인자이다. 제 2열은 상응하는 유전자 서열의 GenBank 접근 번호이다. 제 3열은 상응하는 공식적인 유전자 명칭이다. 제 4열은 선형 모델로 추정된 바와 같은 임상적 이득ㆍ임상적 무이득 환자 사이의 발현 수준에 있어서의 상응하는 조정 평균 배수 변화이다. 제 5열은 선형 모델로부터 유도된 바와 같은 임상적 이득ㆍ임상적 무이득 환자 사이의 발현 수준에 있어서의 차이 시험에 대한 p-값이다.
토의
조직 샘플을 고밀도 올리고뉴클레오티드 마이크로어레이 기술을 사용하여 분석하고, 그 데이터에 통계학적 모델링을 적용함으로써, 본 발명자들은 발현 수준을 통해, 에를로티니브를 사용한 치료로부터 임상적 이득을 얻는 환자를 예측할 수 있는 유전자를 확인할 수 있었다.
복합 기준 (상기 정의한)을 적용하였고, 35개의 공지된 유전자를 나타내는 36개 프로브 집합의 목록 (표 3 참조)이 야기되었다. 이들 유전자의 기능은 복합적이며 항상 잘 분석되거나 완전히 이해되지는 않는다.
Ingenuity 소프트웨어 (Ingenuity Systems, www.ingenuity.com)를 사용하여 표 3에서의 유전자의 기능적 주석을 분석하였다. 상기 소프트웨어는 과학 문헌을 근거로 동의되고 규칙적으로 업데이트된 유전자 주석의 독점적 지식 기초에 대한 인터페이스를 제공한다.
상기 포괄적인 (global) 분석은, 표 3이 상이한 종양 카테고리, 특히 EGFR 억제제 에를로티니브에 대한 반응에 관해, 이를 구별하는데 유용한 유전자를 포함한다는 것을 보여준다.
표 4: 본 발명의 마커 유전자 목록
제 1열은 인간 유전자 서열의 GenBank 접근 번호이고; 제 2열은 상응하는 공식적인 유전자 명칭이며 제 3열은 본 출원에서 사용된 바와 같은 인간 뉴클레오티드 서열의 서열 확인 번호 (Sequence Identification number)이다. 유전자의 여러 변이체가 GenBank에 등록되어 있기 때문에, 특정 유전자에 대해서 표 4에는 하나 이상의 서열 확인 번호가 포함된다.
<110> F. Hoffmann-La Roche AG
<120> Predictive markers for EGFR inhibitor treatment
<130> 24404WO
<150> EP07114292.1
<151> 2007-08-14
<160> 54
<170> PatentIn version 3.4
<210> 1
<211> 894
<212> DNA
<213> Homo sapiens
<400> 1
aggcggggct tgcacacgct ggtcacgcgg tcagctattg acacttcctg gtgggatccg 60
agtgaggcga cggggtaggg gttggcgctc aggcggcgac catggcgtat cacggcctca 120
ctgtgcctct cattgtgatg agcgtgttct ggggcttcgt cggcttcttg gtgccttggt 180
tcatccctaa gggtcctaac cggggagtta tcattaccat gttggtgacc tgttcagttt 240
gctgctatct cttttggctg attgcaattc tggcccaact caaccctctc tttggaccgc 300
aattgaaaaa tgaaaccatc tggtatctga agtatcattg gccttgagga agaagacatg 360
ctctacagtg ctcagtcttt gaggtcacga gaagagaatg ccttctagat gcaaaatcac 420
ctccaaacca gaccactttt cttgacttgc ctgttttggc cattagctgc cttaaacgtt 480
aacagcacat ttgaatgcct tattctacaa tgcagcgtgt tttcctttgc cttttttgca 540
ctttggtgaa ttacgtgcct ccataacctg aactgtgccg actccacaaa acgattatgt 600
actcttctga gatagaagat gctgttcttc tgagagatac gttactctct ccttggaatc 660
tgtggatttg aagatggctc ctgccttctc acgtgggaat cagtgaagtg tttagaaact 720
gctgcaagac aaacaagact ccagtggggt ggtcagtagg agagcacgtt cagagggaag 780
agccatctca acagaatcgc accaaactat actttcagga tgaatttctt ctttctgcca 840
tcttttggaa taaatatttt cctcctttct atggaaatct ggaaaaaaaa aaaa 894
<210> 2
<211> 2540
<212> DNA
<213> Homo sapiens
<400> 2
acgagacgaa gacggaaccg gagccggttg cgggcagtgg acgcggttct gccgagagcc 60
gaagatggca gtgaacgtat actcaacgtc agtgaccagt gataacctaa gtcgacatga 120
catgctggcc tggatcaatg agtctctgca gttgaatctg acaaagatcg aacagttgtg 180
ctcaggggct gcgtattgtc agtttatgga catgctgttc cctggctcca ttgccttgaa 240
gaaagtgaaa ttccaagcta agctagaaca cgagtacatc cagaacttca aaatactaca 300
agcaggtttt aagagaatgg gtgttgacaa aataattcct gtggacaaat tagtaaaagg 360
aaagtttcag gacaattttg aattcgttca gtggttcaag aagtttttcg atgcaaacta 420
tgatggaaaa gactatgacc ctgtggctgc cagacaaggt caagaaactg cagtggctcc 480
ttcccttgtt gctccagctc tgaataaacc gaagaaacct ctcacttcta gcagtgcagc 540
tccccagagg cccatctcaa cacagagaac cgctgcggct cctaaggctg gccctggtgt 600
ggtgcgaaag aaccctggtg tgggcaacgg agacgacgag gcagctgagt tgatgcagca 660
ggtcaacgta ttgaaactta ctgttgaaga cttggagaaa gagagggatt tctacttcgg 720
aaagctacgg aacattgaat tgatttgcca ggagaacgag ggggaaaacg accctgtatt 780
gcagaggatt gtagacattc tgtatgccac agatgaaggc tttgtgatac ctgatgaagg 840
gggcccacag gaggagcaag aagagtatta acagcctgga ccagcagagc aacatcggaa 900
ttcttcactc caaatcatgt gcttaactgt aaaatactcc cttttgttat ccttagagga 960
ctcactggtt tcttttcata agcaaaaagt acctcttctt aaagtgcact ttgcagacgt 1020
ttcactcctt ttccaataag tttgagttag gagcttttac cttgtagcag agcagtatta 1080
acatctagtt ggttcacctg gaaaacagag aggctgaccg tggggctcac catgcggatg 1140
cgggtcacac tgaatgctgg agagatgtat gtaatatgct gaggtggcga cctcagtgga 1200
gaaatgtaaa gactgaattg aattttaagc taatgtgaaa tcagagaatg ttgtaataag 1260
taaatgcctt aagagtattt aaaatatgct tccacatttc aaaatataaa atgtaacatg 1320
acaagagatt ttgcgtttga cattgtgtct gggaaggaag ggccagacct tggaaccttt 1380
ggaacctgct gtcaacaggt cttacagggc tgcttgaacc ctcataggcc taggctttgg 1440
tctaaaagga acatttaaaa agttgccctg taaagttatt tggtgtcatt gaccaattgc 1500
atcccagcta aaaagcaaga ggcatcgttg cctggataat agaggatgtg tttcagccct 1560
gagatgttac agttgaagag cttggtttca ttgagcattt ctctattttt ccagttatcc 1620
cgaaatttct atgtattatt ttttggggaa gtgaggtgtg cccagttttt taatctaaca 1680
actacttttg gggacttgcc cacatctctg ggatttgaat ggggattgta tcccatttta 1740
ctgtctttta ggtttacatt taccacgttt ctcttctctg ctccccttgc ccactgggac 1800
tcctctttgg ctccttgaag tttgctgctt agagttggaa gtgcagcagg caggtgatca 1860
tgctgcaagt tctttctgga cctctggcaa agggagtggt cagtgaaggc catcgttacc 1920
ttgggatctg ccaggctggg gtgttttcgg tatctgctgt tcacagctct ccactgtaat 1980
ccgaatactt tgccagtgca ctaatctctt tggagataaa attcattagt gtgttactaa 2040
atgttaattt tcttttgcgg aaaatacagt accgtgtctg aattaattat taatatttaa 2100
aatacttcat tccttaactc tccctcattt gctttgccca cagcctattc agttcctttg 2160
tttggcagga ttctgcaaaa tgtgtctcac ccactactga gattgttcag cccctgatgt 2220
atttgtattg atttgtttct ggtggtagct tgtcctgaaa tgtgtgtaga aagcaagtat 2280
tttatgataa aaatgttgtg tagtgcatgc tctgtgtgga attcagagga aaacccagat 2340
tcagtgatta acaatgccaa aaaatgcaag taactagcca ttgttcaaat gacagtggtg 2400
ctatttctct tttgtggcct tttagacttt tgttgcccta aaattccatt ttattgggaa 2460
cccattttcc acctggtctt tcttgacagg gtttttttct actttaaaca gtttctaaat 2520
aaaattctgt atttcaaaaa 2540
<210> 3
<211> 1023
<212> DNA
<213> Homo sapiens
<400> 3
gttggctgcc ggtgagttgg gtgccggtgg agtcgtgttg gtcctcagaa tccccgcgta 60
gccgctgcct cctcctaccc tcgccatgtt tcttacccgg tctgagtacg acaggggcgt 120
gaatactttt tctcccgaag gaagattatt tcaagtggaa tatgccattg aggctatcaa 180
gcttggttct acagccattg ggatccagac atcagagggt gtgtgcctag ctgtggagaa 240
gagaattact tccccactga tggagcccag cagcattgag aaaattgtag agattgatgc 300
tcacataggt tgtgccatga gtgggctaat tgctgatgct aagactttaa ttgataaagc 360
cagagtggag acacagaacc actggttcac ctacaatgag acaatgacag tggagagtgt 420
gacccaagct gtgtccaatc tggctttgca gtttggagaa gaagatgcag atccaggtgc 480
catgtctcgt ccctttggag tagcattatt atttggagga gttgatgaga aaggacccca 540
gctgtttcat atggacccat ctgggacctt tgtacagtgt gatgctcgag caattggctc 600
tgcttcagag ggtgcccaga gctccttgca agaagtttac cacaagtcta tgactttgaa 660
agaagccatc aagtcttcac tcatcatcct caaacaagta atggaggaga agctgaatgc 720
aacaaacatt gagctagcca cagtgcagcc tggccagaat ttccacatgt tcacaaagga 780
agaacttgaa gaggttatca aggacattta aggaatcctg atcctcagaa cttctctggg 840
acaatttcag ttctaataat gtccttaaat tttatttcca gctcctgttc cttggaaaat 900
ctccattgta tgtgcatttt ttaaatgatg tctgtacata aaggcagttc tgaaataaag 960
aaaattttaa aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1020
aaa 1023
<210> 4
<211> 3309
<212> DNA
<213> Homo sapiens
<400> 4
ttcagcccct ctcccgggct gcgcctccgc actccgggcc cgggcagaag ggggtgcgcc 60
tcggccccac cacccaggga gcagccgagc tgaaaggccg ggaaccgcgg cttgcgggga 120
ccacagctcc cgaaagcgac gttcggccac cggaggagcg ggagccaagc aggcggagct 180
cggcgggaga ggtgcgggcc gaatccgagc cgagcggaga ggaatccggc agtagagagc 240
ggactccagc cggcggaccc tgcagccctc gcctgggaca gcggcgcgct gggcaggcgc 300
ccaagagagc atcgagcagc ggaacccgcg aagccggccc gcagccgcga cccgcgcagc 360
ctgccgctct cccgccgccg gtccgggcag catgaggcgc gcggcgctct ggctctggct 420
gtgcgcgctg gcgctgagcc tgcagccggc cctgccgcaa attgtggcta ctaatttgcc 480
ccctgaagat caagatggct ctggggatga ctctgacaac ttctccggct caggtgcagg 540
tgctttgcaa gatatcacct tgtcacagca gaccccctcc acttggaagg acacgcagct 600
cctgacggct attcccacgt ctccagaacc caccggcctg gaggctacag ctgcctccac 660
ctccaccctg ccggctggag aggggcccaa ggagggagag gctgtagtcc tgccagaagt 720
ggagcctggc ctcaccgccc gggagcagga ggccaccccc cgacccaggg agaccacaca 780
gctcccgacc actcatcagg cctcaacgac cacagccacc acggcccagg agcccgccac 840
ctcccacccc cacagggaca tgcagcctgg ccaccatgag acctcaaccc ctgcaggacc 900
cagccaagct gaccttcaca ctccccacac agaggatgga ggtccttctg ccaccgagag 960
ggctgctgag gatggagcct ccagtcagct cccagcagca gagggctctg gggagcagga 1020
cttcaccttt gaaacctcgg gggagaatac ggctgtagtg gccgtggagc ctgaccgccg 1080
gaaccagtcc ccagtggatc agggggccac gggggcctca cagggcctcc tggacaggaa 1140
agaggtgctg ggaggggtca ttgccggagg cctcgtgggg ctcatctttg ctgtgtgcct 1200
ggtgggtttc atgctgtacc gcatgaagaa gaaggacgaa ggcagctact ccttggagga 1260
gccgaaacaa gccaacggcg gggcctacca gaagcccacc aaacaggagg aattctatgc 1320
ctgacgcggg agccatgcgc cccctccgcc ctgccactca ctaggccccc acttgcctct 1380
tccttgaaga actgcaggcc ctggcctccc ctgccaccag gccacctccc cagcattcca 1440
gcccctctgg tcgctcctgc ccacggagtc gtggggtgtg ctgggagctc cactctgctt 1500
ctctgacttc tgcctggaga cttagggcac caggggtttc tcgcatagga cctttccacc 1560
acagccagca cctggcatcg caccattctg actcggtttc tccaaactga agcagcctct 1620
ccccaggtcc agctctggag gggaggggga tccgactgct ttggacctaa atggcctcat 1680
gtggctggaa gatcctgcgg gtggggcttg gggctcacac acctgtagca cttactggta 1740
ggaccaagca tcttgggggg gtggccgctg agtggcaggg gacaggagtc cactttgttt 1800
cgtggggagg tctaatctag atatcgactt gtttttgcac atgtttcctc tagttctttg 1860
ttcatagccc agtagacctt gttacttctg aggtaagtta agtaagttga ttcggtatcc 1920
ccccatcttg cttccctaat ctatggtcgg gagacagcat cagggttaag aagacttttt 1980
tttttttttt ttaaactagg agaaccaaat ctggaagcca aaatgtaggc ttagtttgtg 2040
tgttgtctct tgagtttgtc gctcatgtgt gcaacagggt atggactatc tgtctggtgg 2100
ccccgtttct ggtggtctgt tggcaggctg gccagtccag gctgccgtgg ggccgccgcc 2160
tctttcaagc agtcgtgcct gtgtccatgc gctcagggcc atgctgaggc ctgggccgct 2220
gccacgttgg agaagcccgt gtgagaagtg aatgctggga ctcagccttc agacagagag 2280
gactgtaggg agggcggcag gggcctggag atcctcctgc agaccacgcc cgtcctgcct 2340
gtggcgccgt ctccaggggc tgcttcctcc tggaaattga cgaggggtgt cttgggcaga 2400
gctggctctg agcgcctcca tccaaggcca ggttctccgt tagctcctgt ggccccaccc 2460
tgggccctgg gctggaatca ggaatatttt ccaaagagtg atagtctttt gcttttggca 2520
aaactctact taatccaatg ggtttttccc tgtacagtag attttccaaa tgtaataaac 2580
tttaatataa agtagtcctg tgaatgccac tgccttcgct tcttgcctct gtgctgtgtg 2640
tgacgtgacc ggacttttct gcaaacacca acatgttggg aaacttggct cgaatctctg 2700
tgccttcgtc tttcccatgg ggagggattc tggttccagg gtccctctgt gtatttgctt 2760
ttttgttttg gctgaaattc tcctggaggt cggtaggttc agccaaggtt ttataaggct 2820
gatgtcaatt tctgtgttgc caagctccaa gccccatctt ctaaatggca aaggaaggtg 2880
gatggcccca gcacagcttg acctgaggct gtggtcacag cggaggtgtg gagccgaggc 2940
ctaccccgca gacaccttgg acatcctcct cccacccggc tgcagaggcc agaggccccc 3000
agcccagggc tcctgcactt acttgcttat ttgacaacgt ttcagcgact ccgttggcca 3060
ctccgagagg tgggccagtc tgtggatcag agatgcacca ccaagccaag ggaacctgtg 3120
tccggtattc gatactgcga ctttctgcct ggagtgtatg actgcacatg actcgggggt 3180
ggggaaaggg gtcggctgac catgctcatc tgctggtccg tgggacggtg cccaagccag 3240
aggctgggtt catttgtgta acgacaataa acggtacttg tcatttcggg caaaaaaaaa 3300
aaaaaaaaa 3309
<210> 5
<211> 3217
<212> DNA
<213> Homo sapiens
<400> 5
ggccgggaga cctggcggag ctgggggtgg ggggccagtt tttgcaacgg ctaaggaagg 60
gcctgtgggt ttattataag gcggagctcg gcgggagagg tgcgggccga atccgagccg 120
agcggagagg aatccggcag tagagagcgg actccagccg gcggaccctg cagccctcgc 180
ctgggacagc ggcgcgctgg gcaggcgccc aagagagcat cgagcagcgg aacccgcgaa 240
gccggcccgc agccgcgacc cgcgcagcct gccgctctcc cgccgccggt ccgggcagca 300
tgaggcgcgc ggcgctctgg ctctggctgt gcgcgctggc gctgagcctg cagccggccc 360
tgccgcaaat tgtggctact aatttgcccc ctgaagatca agatggctct ggggatgact 420
ctgacaactt ctccggctca ggtgcaggtg ctttgcaaga tatcaccttg tcacagcaga 480
ccccctccac ttggaaggac acgcagctcc tgacggctat tcccacgtct ccagaaccca 540
ccggcctgga ggctacagct gcctccacct ccaccctgcc ggctggagag gggcccaagg 600
agggagaggc tgtagtcctg ccagaagtgg agcctggcct caccgcccgg gagcaggagg 660
ccaccccccg acccagggag accacacagc tcccgaccac tcatcaggcc tcaacgacca 720
cagccaccac ggcccaggag cccgccacct cccaccccca cagggacatg cagcctggcc 780
accatgagac ctcaacccct gcaggaccca gccaagctga ccttcacact ccccacacag 840
aggatggagg tccttctgcc accgagaggg ctgctgagga tggagcctcc agtcagctcc 900
cagcagcaga gggctctggg gagcaggact tcacctttga aacctcgggg gagaatacgg 960
ctgtagtggc cgtggagcct gaccgccgga accagtcccc agtggatcag ggggccacgg 1020
gggcctcaca gggcctcctg gacaggaaag aggtgctggg aggggtcatt gccggaggcc 1080
tcgtggggct catctttgct gtgtgcctgg tgggtttcat gctgtaccgc atgaagaaga 1140
aggacgaagg cagctactcc ttggaggagc cgaaacaagc caacggcggg gcctaccaga 1200
agcccaccaa acaggaggaa ttctatgcct gacgcgggag ccatgcgccc cctccgccct 1260
gccactcact aggcccccac ttgcctcttc cttgaagaac tgcaggccct ggcctcccct 1320
gccaccaggc cacctcccca gcattccagc ccctctggtc gctcctgccc acggagtcgt 1380
ggggtgtgct gggagctcca ctctgcttct ctgacttctg cctggagact tagggcacca 1440
ggggtttctc gcataggacc tttccaccac agccagcacc tggcatcgca ccattctgac 1500
tcggtttctc caaactgaag cagcctctcc ccaggtccag ctctggaggg gagggggatc 1560
cgactgcttt ggacctaaat ggcctcatgt ggctggaaga tcctgcgggt ggggcttggg 1620
gctcacacac ctgtagcact tactggtagg accaagcatc ttgggggggt ggccgctgag 1680
tggcagggga caggagtcca ctttgtttcg tggggaggtc taatctagat atcgacttgt 1740
ttttgcacat gtttcctcta gttctttgtt catagcccag tagaccttgt tacttctgag 1800
gtaagttaag taagttgatt cggtatcccc ccatcttgct tccctaatct atggtcggga 1860
gacagcatca gggttaagaa gacttttttt tttttttttt aaactaggag aaccaaatct 1920
ggaagccaaa atgtaggctt agtttgtgtg ttgtctcttg agtttgtcgc tcatgtgtgc 1980
aacagggtat ggactatctg tctggtggcc ccgtttctgg tggtctgttg gcaggctggc 2040
cagtccaggc tgccgtgggg ccgccgcctc tttcaagcag tcgtgcctgt gtccatgcgc 2100
tcagggccat gctgaggcct gggccgctgc cacgttggag aagcccgtgt gagaagtgaa 2160
tgctgggact cagccttcag acagagagga ctgtagggag ggcggcaggg gcctggagat 2220
cctcctgcag accacgcccg tcctgcctgt ggcgccgtct ccaggggctg cttcctcctg 2280
gaaattgacg aggggtgtct tgggcagagc tggctctgag cgcctccatc caaggccagg 2340
ttctccgtta gctcctgtgg ccccaccctg ggccctgggc tggaatcagg aatattttcc 2400
aaagagtgat agtcttttgc ttttggcaaa actctactta atccaatggg tttttccctg 2460
tacagtagat tttccaaatg taataaactt taatataaag tagtcctgtg aatgccactg 2520
ccttcgcttc ttgcctctgt gctgtgtgtg acgtgaccgg acttttctgc aaacaccaac 2580
atgttgggaa acttggctcg aatctctgtg ccttcgtctt tcccatgggg agggattctg 2640
gttccagggt ccctctgtgt atttgctttt ttgttttggc tgaaattctc ctggaggtcg 2700
gtaggttcag ccaaggtttt ataaggctga tgtcaatttc tgtgttgcca agctccaagc 2760
cccatcttct aaatggcaaa ggaaggtgga tggccccagc acagcttgac ctgaggctgt 2820
ggtcacagcg gaggtgtgga gccgaggcct accccgcaga caccttggac atcctcctcc 2880
cacccggctg cagaggccag aggcccccag cccagggctc ctgcacttac ttgcttattt 2940
gacaacgttt cagcgactcc gttggccact ccgagaggtg ggccagtctg tggatcagag 3000
atgcaccacc aagccaaggg aacctgtgtc cggtattcga tactgcgact ttctgcctgg 3060
agtgtatgac tgcacatgac tcgggggtgg ggaaaggggt cggctgacca tgctcatctg 3120
ctggtccgtg ggacggtgcc caagccagag gctgggttca tttgtgtaac gacaataaac 3180
ggtacttgtc atttcgggca aaaaaaaaaa aaaaaaa 3217
<210> 6
<211> 4369
<212> DNA
<213> Homo sapiens
<400> 6
gtcccaggcg gttccgctca acagacgctg ctgtggctgc gccgggctgc gacactgcag 60
ttgtctacgc ggccggggcc gggacgagga ggcgttggac ggggtcgcat acgttcgtcc 120
cctcgcattg cggccccgac agctgcgcca ggatccccgg gcggcggcgc ggggcgtgaa 180
cgctctgggg ctcagccagg cctgcgcggg cccgaggccg gaggaacccg gactccggcg 240
tagcggtttt gacacaaggg cgcatatctt caaagcacct agtacctcct accattgtca 300
actgatacag aattcgttgt tgggaaggac tggggaaaca gctgtaacat ttgccaccct 360
cagaagctgc tggtcctgtg tcacaccacc ttagcctctt gatcgaggaa gattctcgct 420
gaagtctgtt aattctactt tttgagtact tatgaataac cacgtgtctt caaaaccatc 480
taccatgaag ctaaaacata ccatcaaccc tattctttta tattttatac attttctaat 540
atcactttat actattttaa catacattcc gttttatttt ttctccgagt caagacaaga 600
aaaatcaaac cgaattaaag caaagcctgt aaattcaaaa cctgattctg catacagatc 660
tgttaatagt ttggatggtt tggcttcagt attataccct ggatgtgata ctttagataa 720
agtttttaca tatgcaaaaa acaaatttaa gaacaaaaga ctcttgggaa cacgtgaagt 780
tttaaatgag gaagatgaag tacaaccaaa tggaaaaatt tttaaaaagg ttattcttgg 840
acagtataat tggctttcct atgaagatgt ctttgttcga gcctttaatt ttggaaatgg 900
attacagatg ttgggtcaga aaccaaagac caacatcgcc atcttctgtg agaccagggc 960
cgagtggatg atagctgcac aggcgtgttt tatgtataat tttcagcttg ttacattata 1020
tgccactcta ggaggtccag ccattgttca tgcattaaat gaaacagagg tgaccaacat 1080
cattactagt aaagaactct tacaaacaaa gttgaaggat atagtttctt tggtcccacg 1140
cctgcggcac atcatcactg ttgatggaaa gccaccgacc tggtccgagt tccccaaggg 1200
catcattgtg cataccatgg ctgcagtgga ggccctggga gccaaggcca gcatggaaaa 1260
ccaacctcat agcaaaccat tgccctcaga tattgcagta atcatgtaca caagtggatc 1320
cacaggactt ccaaagggag tcatgatctc acatagtaac attattgctg gtataactgg 1380
gatggcagaa aggattccag aactaggaga ggaagatgtc tacattggat atttgcctct 1440
ggcccatgtt ctagaattaa gtgctgagct tgtctgtctt tctcacggat gccgcattgg 1500
ttactcttca ccacagactt tagcagatca gtcttcaaaa attaaaaaag gaagcaaagg 1560
ggatacatcc atgttgaaac caacactgat ggcagcagtt ccggaaatca tggatcggat 1620
ctacaaaaat gtcatgaata aagtcagtga aatgagtagt tttcaacgta atctgtttat 1680
tctggcctat aattacaaaa tggaacagat ttcaaaagga cgtaatactc cactgtgcga 1740
cagctttgtt ttccggaaag ttcgaagctt gctaggggga aatattcgtc tcctgttgtg 1800
tggtggcgct ccactttctg caaccacgca gcgattcatg aacatctgtt tctgctgtcc 1860
tgttggtcag ggatacgggc tcactgaatc tgctggggct ggaacaattt ccgaagtgtg 1920
ggactacaat actggcagag tgggagcacc attagtttgc tgtgaaatca aattaaaaaa 1980
ctgggaggaa ggtggatact ttaatactga taagccacac cccaggggtg aaattcttat 2040
tgggggccaa agtgtgacaa tggggtacta caaaaatgaa gcaaaaacaa aagctgattt 2100
ctttgaagat gaaaatggac aaaggtggct ctgtactggg gatattggag agtttgaacc 2160
cgatggatgc ttaaagatta ttgatcgtaa aaaggacctt gtaaaactac aggcagggga 2220
atatgtttct cttgggaaag tagaggcagc tttgaagaat cttccactag tagataacat 2280
ttgtgcatat gcaaacagtt atcattctta tgtcattgga tttgttgtgc caaatcaaaa 2340
ggaactaact gaactagctc gaaagaaagg acttaaaggg acttgggagg agctgtgtaa 2400
cagttgtgaa atggaaaatg aggtacttaa agtgctttcc gaagctgcta tttcagcaag 2460
tctggaaaag tttgaaattc cagtaaaaat tcgtttgagt cctgaaccgt ggacccctga 2520
aactggtctg gtgacagatg ccttcaagct gaaacgcaaa gagcttaaaa cacattacca 2580
ggcggacatt gagcgaatgt atggaagaaa ataattattc tcttctggca tcagtttgct 2640
acagtgagct cagatcaaat aggaaaatac ttgaaatgca tgtctcaagc tgcaaggcaa 2700
actccattcc tcatattaaa ctattacttc tcatgacgtc accattttta actgacagga 2760
ttagtaaaac attaagacag caaacttgtg tctgtctctt ctttcatttt ccccgccacc 2820
aacttacttt accacctatg actgtacttg tcagtatgag aatttttctg aatcatattg 2880
gggaagcagt gattttaaaa cctcaagttt ttaaacatga tttatatgtt ctgtataatg 2940
ttcagtttgt aactttttaa aagtttggat gtatagaggg ataaatagga aatataagaa 3000
ttggttattt gggggctttt ttacttactg tatttaaaaa tacaagggta ttgatatgaa 3060
attatgtaaa tttcaaatgc ttatgaatca aatcattgtt gaacaaaaga tttgttgctg 3120
tgtaattatt gtcttgtatg catttgagag aaataaatat acccatactt atgttttaag 3180
aagttgagat cttgtgaata tatgcctgtc agtgtcttct ttatatattt attttttatt 3240
agaaaaaatg aagtttggtt ggtgatgcat gaaacaaaat agcaagagag ggttatagtt 3300
taatagtaag ggagataaca cagcatgtgt agcaccagtt gataattggt ctctagtagc 3360
ttactgtcaa aatgttcaat gaagtcttct gttcatctgt tgaaactagg aaaataccca 3420
aacttaaatg gaagaattct gaaagagagg atagaattta aagaacaaga gtatataaag 3480
ttattctttg aatatttcgt tgactatatg tacattgagt tatctatatt tgtaaacaaa 3540
ttagtcatgg aaaattattc tatctcaaag tctcctttta gtctagataa tcattatttc 3600
attttaaaat tagtgttttt cctagtttgc actgatgcgt gtatggatgt gtgtgagtca 3660
gtggtagctt atttaaaaag caccttatcc tttctcccat aacctttgta cactaaaaaa 3720
tgaaagaatt tagaatgtat ttgatgatag cattctcact aagacacatg agaatttaac 3780
tttataaccg cgtgagttaa gatttaattc ataggttttg atgtcattgt tgaagttatt 3840
tgtaattcag aaaccttgct tgtgtgatac atagtctctt catttattac tgcttgtctg 3900
ttgttatatc tggattatca aaagcaatag tgcaccaatt aagatgtgct caaatcagga 3960
cttaaatcat aggcaccaca tttttcatgt cagactagtt actttgttga ttctcagtta 4020
ctgtaggcat caaaaggcaa aaatcaaaaa aaaaaaaaac aaaaacaaaa aaaaagatga 4080
acctaggtct gtgtaaagta aggggagtgt taggagcagc caggactgtg tagtgtgtgt 4140
ttggttgcat cacaaacatc gtatgtggag acattgcaat acagtgtttt ttgttttcaa 4200
cttttcttgt attgtatatt tgtattatgt tttgaatgct tttctctttt cataattaaa 4260
tattaatgtt tgggataact gccaagaaga agtaaaaata ttgaatggaa cttctatatg 4320
aggatgctgt gatctaaaaa ttaaatctca gtgggcggag aaaaaaaaa 4369
<210> 7
<211> 4262
<212> DNA
<213> Homo sapiens
<400> 7
gtcccaggcg gttccgctca acagacgctg ctgtggctgc gccgggctgc gacactgcag 60
ttgtctacgc ggccggggcc gggacgagga ggcgttggac ggggtcgcat acgttcgtcc 120
cctcgcattg cggccccgac agctgcgcca ggatccccgg gcggcggcgc ggggcgtgaa 180
cgctctgggg ctcagccagg cctgcgcggg cccgaggccg gaggaacccg gactccggcg 240
tagcggtttt gacacaaggg cgcatatctt caaagcacct agtacctcct accattgtca 300
actgattctc gctgaagtct gttaattcta ctttttgagt acttatgaat aaccacgtgt 360
cttcaaaacc atctaccatg aagctaaaac ataccatcaa ccctattctt ttatatttta 420
tacattttct aatatcactt tatactattt taacatacat tccgttttat tttttctccg 480
agtcaagaca agaaaaatca aaccgaatta aagcaaagcc tgtaaattca aaacctgatt 540
ctgcatacag atctgttaat agtttggatg gtttggcttc agtattatac cctggatgtg 600
atactttaga taaagttttt acatatgcaa aaaacaaatt taagaacaaa agactcttgg 660
gaacacgtga agttttaaat gaggaagatg aagtacaacc aaatggaaaa atttttaaaa 720
aggttattct tggacagtat aattggcttt cctatgaaga tgtctttgtt cgagccttta 780
attttggaaa tggattacag atgttgggtc agaaaccaaa gaccaacatc gccatcttct 840
gtgagaccag ggccgagtgg atgatagctg cacaggcgtg ttttatgtat aattttcagc 900
ttgttacatt atatgccact ctaggaggtc cagccattgt tcatgcatta aatgaaacag 960
aggtgaccaa catcattact agtaaagaac tcttacaaac aaagttgaag gatatagttt 1020
ctttggtccc acgcctgcgg cacatcatca ctgttgatgg aaagccaccg acctggtccg 1080
agttccccaa gggcatcatt gtgcatacca tggctgcagt ggaggccctg ggagccaagg 1140
ccagcatgga aaaccaacct catagcaaac cattgccctc agatattgca gtaatcatgt 1200
acacaagtgg atccacagga cttccaaagg gagtcatgat ctcacatagt aacattattg 1260
ctggtataac tgggatggca gaaaggattc cagaactagg agaggaagat gtctacattg 1320
gatatttgcc tctggcccat gttctagaat taagtgctga gcttgtctgt ctttctcacg 1380
gatgccgcat tggttactct tcaccacaga ctttagcaga tcagtcttca aaaattaaaa 1440
aaggaagcaa aggggataca tccatgttga aaccaacact gatggcagca gttccggaaa 1500
tcatggatcg gatctacaaa aatgtcatga ataaagtcag tgaaatgagt agttttcaac 1560
gtaatctgtt tattctggcc tataattaca aaatggaaca gatttcaaaa ggacgtaata 1620
ctccactgtg cgacagcttt gttttccgga aagttcgaag cttgctaggg ggaaatattc 1680
gtctcctgtt gtgtggtggc gctccacttt ctgcaaccac gcagcgattc atgaacatct 1740
gtttctgctg tcctgttggt cagggatacg ggctcactga atctgctggg gctggaacaa 1800
tttccgaagt gtgggactac aatactggca gagtgggagc accattagtt tgctgtgaaa 1860
tcaaattaaa aaactgggag gaaggtggat actttaatac tgataagcca caccccaggg 1920
gtgaaattct tattgggggc caaagtgtga caatggggta ctacaaaaat gaagcaaaaa 1980
caaaagctga tttctttgaa gatgaaaatg gacaaaggtg gctctgtact ggggatattg 2040
gagagtttga acccgatgga tgcttaaaga ttattgatcg taaaaaggac cttgtaaaac 2100
tacaggcagg ggaatatgtt tctcttggga aagtagaggc agctttgaag aatcttccac 2160
tagtagataa catttgtgca tatgcaaaca gttatcattc ttatgtcatt ggatttgttg 2220
tgccaaatca aaaggaacta actgaactag ctcgaaagaa aggacttaaa gggacttggg 2280
aggagctgtg taacagttgt gaaatggaaa atgaggtact taaagtgctt tccgaagctg 2340
ctatttcagc aagtctggaa aagtttgaaa ttccagtaaa aattcgtttg agtcctgaac 2400
cgtggacccc tgaaactggt ctggtgacag atgccttcaa gctgaaacgc aaagagctta 2460
aaacacatta ccaggcggac attgagcgaa tgtatggaag aaaataatta ttctcttctg 2520
gcatcagttt gctacagtga gctcagatca aataggaaaa tacttgaaat gcatgtctca 2580
agctgcaagg caaactccat tcctcatatt aaactattac ttctcatgac gtcaccattt 2640
ttaactgaca ggattagtaa aacattaaga cagcaaactt gtgtctgtct cttctttcat 2700
tttccccgcc accaacttac tttaccacct atgactgtac ttgtcagtat gagaattttt 2760
ctgaatcata ttggggaagc agtgatttta aaacctcaag tttttaaaca tgatttatat 2820
gttctgtata atgttcagtt tgtaactttt taaaagtttg gatgtataga gggataaata 2880
ggaaatataa gaattggtta tttgggggct tttttactta ctgtatttaa aaatacaagg 2940
gtattgatat gaaattatgt aaatttcaaa tgcttatgaa tcaaatcatt gttgaacaaa 3000
agatttgttg ctgtgtaatt attgtcttgt atgcatttga gagaaataaa tatacccata 3060
cttatgtttt aagaagttga gatcttgtga atatatgcct gtcagtgtct tctttatata 3120
tttatttttt attagaaaaa atgaagtttg gttggtgatg catgaaacaa aatagcaaga 3180
gagggttata gtttaatagt aagggagata acacagcatg tgtagcacca gttgataatt 3240
ggtctctagt agcttactgt caaaatgttc aatgaagtct tctgttcatc tgttgaaact 3300
aggaaaatac ccaaacttaa atggaagaat tctgaaagag aggatagaat ttaaagaaca 3360
agagtatata aagttattct ttgaatattt cgttgactat atgtacattg agttatctat 3420
atttgtaaac aaattagtca tggaaaatta ttctatctca aagtctcctt ttagtctaga 3480
taatcattat ttcattttaa aattagtgtt tttcctagtt tgcactgatg cgtgtatgga 3540
tgtgtgtgag tcagtggtag cttatttaaa aagcacctta tcctttctcc cataaccttt 3600
gtacactaaa aaatgaaaga atttagaatg tatttgatga tagcattctc actaagacac 3660
atgagaattt aactttataa ccgcgtgagt taagatttaa ttcataggtt ttgatgtcat 3720
tgttgaagtt atttgtaatt cagaaacctt gcttgtgtga tacatagtct cttcatttat 3780
tactgcttgt ctgttgttat atctggatta tcaaaagcaa tagtgcacca attaagatgt 3840
gctcaaatca ggacttaaat cataggcacc acatttttca tgtcagacta gttactttgt 3900
tgattctcag ttactgtagg catcaaaagg caaaaatcaa aaaaaaaaaa aacaaaaaca 3960
aaaaaaaaga tgaacctagg tctgtgtaaa gtaaggggag tgttaggagc agccaggact 4020
gtgtagtgtg tgtttggttg catcacaaac atcgtatgtg gagacattgc aatacagtgt 4080
tttttgtttt caacttttct tgtattgtat atttgtatta tgttttgaat gcttttctct 4140
tttcataatt aaatattaat gtttgggata actgccaaga agaagtaaaa atattgaatg 4200
gaacttctat atgaggatgc tgtgatctaa aaattaaatc tcagtgggcg gagaaaaaaa 4260
aa 4262
<210> 8
<211> 1906
<212> DNA
<213> Homo sapiens
<400> 8
ggcgccgccg ccgctcccga ggcccctgcc gccgccgctc ccgctgctgt cgccgcgcag 60
agccggagca ggagccacgg ccgagaggag ggaggaggag gaggaggagg tggaggaggt 120
ggaggaggtg gaggaggcgc cggaccgggg gggatagatt cccagaagtg ggataactgg 180
atcagagggt gattaccctg tgtataagag tatgtgtctc actgcacctt caatggcatt 240
gagtagatcg tcagtattta aacagatcac atcatgcgtg agtacaagct agtggtcctt 300
ggttcaggag gcgttgggaa gtctgctctg acagttcagt ttgttcaggg aatttttgtt 360
gaaaaatatg acccaacgat agaagattcc tacagaaagc aagttgaagt cgattgccaa 420
cagtgtatgc tcgaaatcct ggatactgca gggacagagc aatttacagc aatgagggat 480
ttgtatatga agaacggcca aggttttgca ctagtatatt ctattacagc tcagtccacg 540
tttaacgact tacaggacct gagggaacag attttacggg ttaaggacac ggaagatgtt 600
ccaatgattt tggttggcaa taaatgtgac ctggaagatg agcgagtagt tggcaaagag 660
cagggccaga atttagcaag acagtggtgt aactgtgcct ttttagaatc ttctgcaaag 720
tcaaagatca atgttaatga gatattttat gacctggtca gacagataaa taggaaaaca 780
ccagtggaaa agaagaagcc taaaaagaaa tcatgtctgc tgctctaggc ccatagtcag 840
cagcagctct gagccagatt acaggaatga agaactgttg cctaattgga aagtgccagc 900
attccagact tcaaaaataa aaaatctgaa gaggcttctc ctgttttata tattatgtga 960
agaatttaga tcttatattg gtttgcacaa gttccctgga gaaaaaaatt gctctgtgta 1020
tatctcttgg aaaataagac aatagtattt ctcctttgca atagcagtta taacagatgt 1080
gaaaatatac ttgactctaa tatgattata caaaagagca tggatgcatt tcaaatgtta 1140
gatattgcta ctataatcaa atgatttcat attgatcttt ttatcatgat cctccctatc 1200
aagcactaaa aagttgaacc attatacttt atatctgtaa tgatactgat tatgaaatgt 1260
cccctcaaac tcattgcagc agataacttt tttgagtcat tgacttcatt ttatatttaa 1320
aaaattatgg aatatcatct gtcattatat tctaattaaa attgtgcata atgctttgga 1380
aaaatgggtc ttttatagga aaaaaactgg gataactgat ttctatggct ttcaaagcta 1440
aaatatataa tatactaaac caactctaat attgcttctt gtgttttact gtcagattaa 1500
attacagctt ttatggatga ttaaatttta gtacattttc atttggtttg tgtgtttttg 1560
ttattgttta tagattaaag cgtttatttt ataatgacca cattgtttta aatgcgacag 1620
tagctccttt ctgcctagta tctgcagaac actggcttta aactatacta agtaactggt 1680
gatttctcta ggaacagacc tcgcactttc tgttctaaat atatttattc ctactataca 1740
gtaaaataca tcagacaaca tagaatagtt ttgtatattc tctcttgatc ttaaagattg 1800
tatcttattg aatatcccac tgtatattat ttttatatgt aaaaagataa gtttaatact 1860
gtatcagggt ttaactttta ctatttcaga tcttccacag cttgta 1906
<210> 9
<211> 1812
<212> DNA
<213> Homo sapiens
<400> 9
ggcgccgccg ccgctcccga ggcccctgcc gccgccgctc ccgctgctgt cgccgcgcag 60
agccggagca ggagccacgg ccgagaggag ggaggaggag gaggaggagg tggaggaggt 120
ggaggaggtg gaggaggcgc cggaccgggg ggatcgtcag tatttaaaca gatcacatca 180
tgcgtgagta caagctagtg gtccttggtt caggaggcgt tgggaagtct gctctgacag 240
ttcagtttgt tcagggaatt tttgttgaaa aatatgaccc aacgatagaa gattcctaca 300
gaaagcaagt tgaagtcgat tgccaacagt gtatgctcga aatcctggat actgcaggga 360
cagagcaatt tacagcaatg agggatttgt atatgaagaa cggccaaggt tttgcactag 420
tatattctat tacagctcag tccacgttta acgacttaca ggacctgagg gaacagattt 480
tacgggttaa ggacacggaa gatgttccaa tgattttggt tggcaataaa tgtgacctgg 540
aagatgagcg agtagttggc aaagagcagg gccagaattt agcaagacag tggtgtaact 600
gtgccttttt agaatcttct gcaaagtcaa agatcaatgt taatgagata ttttatgacc 660
tggtcagaca gataaatagg aaaacaccag tggaaaagaa gaagcctaaa aagaaatcat 720
gtctgctgct ctaggcccat agtcagcagc agctctgagc cagattacag gaatgaagaa 780
ctgttgccta attggaaagt gccagcattc cagacttcaa aaataaaaaa tctgaagagg 840
cttctcctgt tttatatatt atgtgaagaa tttagatctt atattggttt gcacaagttc 900
cctggagaaa aaaattgctc tgtgtatatc tcttggaaaa taagacaata gtatttctcc 960
tttgcaatag cagttataac agatgtgaaa atatacttga ctctaatatg attatacaaa 1020
agagcatgga tgcatttcaa atgttagata ttgctactat aatcaaatga tttcatattg 1080
atctttttat catgatcctc cctatcaagc actaaaaagt tgaaccatta tactttatat 1140
ctgtaatgat actgattatg aaatgtcccc tcaaactcat tgcagcagat aacttttttg 1200
agtcattgac ttcattttat atttaaaaaa ttatggaata tcatctgtca ttatattcta 1260
attaaaattg tgcataatgc tttggaaaaa tgggtctttt ataggaaaaa aactgggata 1320
actgatttct atggctttca aagctaaaat atataatata ctaaaccaac tctaatattg 1380
cttcttgtgt tttactgtca gattaaatta cagcttttat ggatgattaa attttagtac 1440
attttcattt ggtttgtgtg tttttgttat tgtttataga ttaaagcgtt tattttataa 1500
tgaccacatt gttttaaatg cgacagtagc tcctttctgc ctagtatctg cagaacactg 1560
gctttaaact atactaagta actggtgatt tctctaggaa cagacctcgc actttctgtt 1620
ctaaatatat ttattcctac tatacagtaa aatacatcag acaacataga atagttttgt 1680
atattctctc ttgatcttaa agattgtatc ttattgaata tcccactgta tattattttt 1740
atatgtaaaa agataagttt aatactgtat cagggtttaa cttttactat ttcagatctt 1800
ccacagcttg ta 1812
<210> 10
<211> 3915
<212> DNA
<213> Homo sapiens
<400> 10
gtggggtggg gtggggctgg gggcttgtcg ccctttcagg ctccaccctt tgcggagatt 60
ataaatagtc atgatcccag cgagacccag agatgcctgt aatggtgaga ctttggatcc 120
ttcctgagga cgtggagaaa actttctgct gagaaggaca ttttgaaggt tttgttggct 180
gaaaaagctg tttctggaat cacccctaga tctttcttga agacttgaat tagattacag 240
cgatggggac acagaaggtc accccagctc tgatatttgc catcacagtt gctacaatcg 300
gctctttcca atttggctac aacactgggg tcatcaatgc tcctgagaag atcataaagg 360
aatttatcaa taaaactttg acggacaagg gaaatgcccc accctctgag gtgctgctca 420
cgtctctctg gtccttgtct gtggccatat tttccgtcgg gggtatgatc ggctcctttt 480
ccgtcggact cttcgtcaac cgctttggca ggcgcaattc aatgctgatt gtcaacctgt 540
tggctgtcac tggtggctgc tttatgggac tgtgtaaagt agctaagtcg gttgaaatgc 600
tgatcctggg tcgcttggtt attggcctct tctgcggact ctgcacaggt tttgtgccca 660
tgtacattgg agagatctcg cctactgccc tgcggggtgc ctttggcact ctcaaccagc 720
tgggcatcgt tgttggaatt ctggtggccc agatctttgg tctggaattc atccttgggt 780
ctgaagagct atggccgctg ctactgggtt ttaccatcct tcctgctatc ctacaaagtg 840
cagcccttcc attttgccct gaaagtccca gatttttgct cattaacaga aaagaagagg 900
agaatgctaa gcagatcctc cagcggttgt ggggcaccca ggatgtatcc caagacatcc 960
aggagatgaa agatgagagt gcaaggatgt cacaagaaaa gcaagtcacc gtgctagagc 1020
tctttagagt gtccagctac cgacagccca tcatcatttc cattgtgctc cagctctctc 1080
agcagctctc tgggatcaat gctgtgttct attactcaac aggaatcttc aaggatgcag 1140
gtgttcaaga gcccatctat gccaccatcg gcgcgggtgt ggttaatact atcttcactg 1200
tagtttctct atttctggtg gaaagggcag gaagaaggac tctgcatatg ataggccttg 1260
gagggatggc tttttgttcc acgctcatga ctgtttcttt gttattaaag gataactata 1320
atgggatgag ctttgtctgt attggggcta tcttggtctt tgtagccttc tttgaaattg 1380
gaccaggccc cattccctgg tttattgtgg ccgaactctt cagccagggc ccccgcccag 1440
ctgcgatggc agtggccggc tgctccaact ggacctccaa cttcctagtc ggattgctct 1500
tcccctccgc tgctcactat ttaggagcct acgtttttat tatcttcacc ggcttcctca 1560
ttaccttctt ggcttttacc ttcttcaaag tccctgagac ccgtggcagg acttttgagg 1620
atatcacacg ggcctttgaa gggcaggcac acggtgcaga tagatctgga aaggacggcg 1680
tcatggagat gaacagcatc gagcctgcta aggagaccac caccaatgtc taagtcgtgc 1740
ctccttccac ctccctcccg gcatgggaaa gccacctctc cctcaacaag ggagagacct 1800
catcaggatg aacccaggac gcttctgaat gctgctactt aattcctttc tcatcccacg 1860
cactccatga gcaccccaag gctgcggttt gttggatctt caatggcttt ttaaatttta 1920
tttcctggac atcctcttct gcttaggaga gaccgagtga acctaccttc atttcaggag 1980
ggattggccg cttggcacat gacaactttg ccagcttttc ctcccttggg ttctgatatt 2040
gccgcactag gggatatagg agaggaaaag taaggtgcag ttcccccaac ctcagactta 2100
ccaggaagca gatacatatg agtgtggaag ccggagggtg tttatgtaag agcaccttcc 2160
tcacttccat acagctctac gtggcaaatt aacttgagtt ttatttattt tatcctctgg 2220
tttaattaca taattttttt ttttttactt taagtttcag gatacatgtg ccgaatgtgc 2280
aggtttgtta cataggtata tatatgccat gatggaaata tttatttttt taagcgtaat 2340
tttgccaaat aataaaaaca gaaggaaatt gagattagag ggaggtgttt aaagagaggt 2400
tatagagtag aagatttgat gctggagagg ttaaggtgca ataagaattt agggagaaat 2460
gttgttcatt attggagggt aaatgatgtg gtgcctgagg tctgtacgtt acctcttaac 2520
aatttctgtc cttcagatgg aaactcttta acttctcgta aaagtcatat acctatataa 2580
taaagctact gatttccttg gagctttttt ctttaagata atagtttaca tgtagtagta 2640
cttgaaatct aggattatta actaatatgg gcattgtagt taatgatggt tgatgggttc 2700
taattttgga tggagtccag ggaagagaaa gtgatttcta gaaagcctgt tcccctcact 2760
ggatgaaata actccttctt gtagtagtct cattactttt gaagtaatcc cgccacctat 2820
ctcgtgggag agccatccaa ataagaaacc taaaataatt ggttcttggt agagattcat 2880
tatttttcca ctttgttctt taggagattt taggtgttga ttttctgttg tattttaact 2940
cataccttta aaggaattcc ccaaagaatg tttatagcaa acttggaatt tgtaacctca 3000
gctctgggag aggatttttt tctgagcgat tattatctaa agtgtgttgt tgctttaggc 3060
tcacggcacg cttgcgtatg tctgttacca tgtcactgtg gtcctatgcc gaatgccctc 3120
aggggacttg aatctttcca ataaaccagg tttagacagt atgagtcaat gtgcagtgta 3180
gcccacactt gagaggatga atgtatgtgc actgtcactt tgctctgggt ggaagtacgt 3240
tattgttgac ttattttctc tgtgtttgtt cctacagccc ctttttcata tgttgctcag 3300
tctccctttc ccttcttggt gcttacacat ctcagaccct ttagccaaac ccttgtcagt 3360
gacagtattt tggttcttag ttctcactgt tccctctgct cctggagcct ttgaataaaa 3420
atgcacgtag ctgaggccgg atgcggtggc tcacgcctgt aatcccagca ctttgggagg 3480
cctaggcggg cggtcagggg ttcgagacca gtctggccaa catcgtgaaa ccctgtctct 3540
actaaaaatg caaaaattag ccgggcgtgg tggcgggcgc ctgtaatccc agctacttgg 3600
gaagctgagg cgggagaatc atgtgaaccc gggacgcagg ggttgcagtg agcggagatc 3660
gcatcattgc actctagcct gggccacagg gcgagactcc gtctcaaaaa aaaaaaaatg 3720
cacatagcta tcgagtgtgc tttagcttga aaaggtgacc ttgcaacttc atgtcaactt 3780
tctggctcct caaacagtag gttggcagta aggcagggtc ccatttctca ctgagaagat 3840
tgtgaatatt tccatatgga ttttctattg ttactctggt tctttgtttt aaaataaaaa 3900
ttctgaatgt acacg 3915
<210> 11
<211> 2410
<212> DNA
<213> Homo sapiens
<400> 11
gtccttttcc tcctgtcctt tgccagcgtt gggccggacc gggccgagcc gggccgcccg 60
ggcgcagtct ttaaccatgg cgtccctctt caagaagaaa accgtggatg atgtaataaa 120
ggaacagaat cgagagttac gaggtacaca gagggctata atcagagatc gagcagcttt 180
agagaaacaa gaaaaacagc tggaattaga aattaagaaa atggccaaga ttggtaataa 240
ggaagcttgc aaagttttag ccaaacaact tgtgcatcta cggaaacaga agacgagaac 300
ttttgctgta agttcaaaag ttacttctat gtctacacaa acaaaagtga tgaattccca 360
aatgaagatg gctggagcaa tgtctaccac agcaaaaaca atgcaggcag ttaacaagaa 420
gatggatcca caaaagacat tacaaacaat gcagaatttc cagaaggaaa acatgaaaat 480
ggaaatgact gaagaaatga tcaatgatac acttgatgac atctttgacg gttctgatga 540
cgaagaagaa agccaggata ttgtgaatca agttcttgat gaaattggaa ttgaaatttc 600
tggaaagatg gccaaagctc catcagctgc tcgaagctta ccatctgcct ctacttcaaa 660
ggctacaatc tcagatgaag agattgaacg gcaactcaag gctttaggag tagattagtc 720
aaaagaagtc atactatttt gcttacttat aattatgtag tataaaccaa gcacagtgca 780
gatttctttt acaaaacaca tgtattttgc aaaaaaaaaa aaaatgaaga ccatgagtga 840
acagttgttt cctaacccat ggctatttag aatcttttgc caaagaatga caatgatgca 900
aaaatgggaa cagtttggat tttaattaga actgtttagg agtgatgatg tgtaaaaagt 960
tgacttctct tttgcatggc acagagaaat tatattcctt acttcatgtc agtttatgtt 1020
ctaaatcttt ttcactgaat ataaaaatct tgttaaatgc cattaggcac caacttaaag 1080
agggttgtaa aaatattaaa agtatatcgt taattctgta tctgttgctt gtcttttgta 1140
agtgattatg tgttatgacc ataggtggtt acagctgcca aattattttt aaatggtcaa 1200
aaagaagagt gctatttaaa catctgtctt aaacaaaaac tgtcataact tttctttttt 1260
ctttttccat taggagaaca ttctagttgg taaatttcaa aatgtgcttg acacctgcct 1320
taaatagcac agacctattg tgcacatctt taaattattt cagctggcag aaaagaatta 1380
catttaaaac tgaaatcaag gcctcaatac aaagattatc ctggctcttt tctatctctg 1440
tgggcctaat tgaaatatgt actcttattt tagacacgcc tctgttaaaa cagaccaggt 1500
tttcctggtc tcagacctat gatgacttgt ccctttgatg tcactactgt gaattgaata 1560
taattagtaa aaatagacga tgaataaata acactttata gtaagaaaac aatatatttt 1620
ggccatctaa aaatgagaat tataattata tgaattataa tttaaactgt ttaattttgt 1680
ttaatgtgta tattgaatct tccaaattga agccattatt ctcaattaag tactacaact 1740
atgacaatgc ttgacctaca tttctaaaat aaaaattcac attttttgat aaataaacta 1800
cagttttacc agaaattact atctaaatgt gtattagcag tattttttaa ggtgaaattg 1860
ccttggtatc taatgaatgt gtagacaggg agataaaatg aaggattgcc agactagtta 1920
gaatagaatt taggattagg ttagttttga aaaatgatgt tgtaatatat gggttctaac 1980
acatcctacc ataaaaactg gaggagatat gtgtaacctg gttaatttgg gatggtggac 2040
attttgggct aatactgaca aaatacatct taggactagt atacatgtga cacggattgc 2100
taggaggaat gaaaaactaa actgtatagt ttatattccg taaaccattt tataatgttc 2160
aaagattagg ttttgttatt gatagtatta aatacacagt ttctcttaac agtgatgggt 2220
gaaaacattt taccggatta tggaatgttt accagaacat gttttgattc ttgaatgtac 2280
ataataatgc catctaactt atttacattc ttgtttacat gtgggagctt ttgttttcaa 2340
aaattatttt gttaaaaaat ctcaataaag atttattatt gttgttcttt tcttaaaaaa 2400
aaaaaaaaaa 2410
<210> 12
<211> 2718
<212> DNA
<213> Homo sapiens
<400> 12
gggctcgagg cgttcggctg aggaagggag cgcacgccgg cggcgcggag gccggctctg 60
cgcttcgggc cgccccctcc ccccaccccg ctcacacccg gcacttactt cggctgtctc 120
cgctgccctc cagcggagac gcagctcctc aggcgcccgg cggtatttgt tgggtcggcg 180
gcgtcaggga ttcgcagtgg cctgtggtcg gcgtcgtccg gccactggtg cgcccccgcg 240
gcaggcagag ctcacgctcc tgtcccccgg ctggtccggg gtctgggcgc cgcgtcgacg 300
gcggctccgc aggacgcgca gaccgggccg cagcccatgc cccgagcgga ctgcattatg 360
aggcacctgc cttacttctg ccggggtcaa gtggtgcggg gcttcggccg cggctccaag 420
cagctgggca tccccacagc taattttcct gagcaagtgg tagataatct tccagctgat 480
atatccactg gtatttacta tggttgggcc agtgttggaa gtggagatgt ccataagatg 540
gtggtgagca taggatggaa cccatattac aagaatacga agaagtctat ggaaacacat 600
atcatgcata ccttcaaaga ggacttctat ggggaaatcc tcaatgtggc cattgttggc 660
tacctgagac cagaaaagaa ctttgattct ttagagtcac ttatttcagc aattcaaggt 720
gatattgaag aagctaagaa acgactagag ttaccagaac atttgaaaat caaagaagac 780
aatttcttcc aggtttctaa aagcaaaata atgaatggcc actgatgaaa aattgtatta 840
tttattcatt cactgttttc tagtgtttct gtgtttatta ctgttcagca tcatcttggt 900
tatatactga aaatcaaaca ctttactaca gttgtgaatt agtttaaacc gtacaatgtt 960
gttatcatat catgcttcaa ctattaaatt aagcccatca tatcatagca ctaaaaagat 1020
tgagttaaaa ataagattta aaaaatatat attgattaaa atgtaccact agaaaggtat 1080
tacatgtgta taagtatggg taaaaaggca agtcactagt ttgagatgaa aactaaaatt 1140
ttcatggtaa aatgccagca tgtatgtact tgtgtagtgt gtacttctaa acagagaagg 1200
cttataaaag taaatgcatt aaggccaagt gcagtggctc acaccggtaa tcccagcact 1260
ttgggaggcc gaggtgggag gattgcttga gctcatgagt tcaagaccag cctgggcaac 1320
atagcgagac tccatctcta taaataaaaa aaaaggaaat gcattaaata gaaggttgat 1380
agtttatcat aaacctgcgg ggaagaaact cagactttct atttttgata ttttgtgcat 1440
taatacatta caaacatgaa gatgtttgta aagttttgtt ttagtcattt tctttgcagt 1500
cacatcattg taccaccttc attattgtat agagctgctt caattctgag tcctctggac 1560
ttcccctgcc tatctgtttg ttgttgttgt tgaagacagt aaaataagtg ttttcaaatc 1620
tatatgtctc ctttttgttg gataatgttt cttcttttta atggtaaata ttcttgttct 1680
tcaacatttt tctttggttc ttttttcctt ttttaggaaa aacaaaacaa cagacttcat 1740
ccttaggttt tctcaagatt taagtgaaca catttacaca tatcaatttc ttaaagaaca 1800
caaaatgttt cctccctagc aaaactattt aagagccaat taaactatga aatagttata 1860
aaattatttt taatatttaa ggccttgaaa ttatattcca aggcaaatct aaatgggtgt 1920
agttgtatat gcacgatgta atttaatgct aaagagtact tacagcttga gggaaaagca 1980
taaagtttta gttaaatagc cttcatactg tggatttttc ctcctactaa ctaatatgtg 2040
ggaaattaag attacagatg ctttgggccc cctcaaacag tacattgcta cagttcactg 2100
tagcaacaga tttggtggtg atggggggat agaggtagaa gcagatagaa ggtaatttta 2160
aagttaattt attatgaatc attttcccct aatctgcata aatgaattag aactgatttt 2220
aataaaaata ttctgtgtaa aaagtactca gaaaaacatc taaagctgtt ggagaagagg 2280
gactcatata aatagttgga ttgcgttttg ctttttattt ctttataaaa atatgtcaaa 2340
aacagttttt aattttagaa atcttatact tgaaagaaac ctcaattatc agtggcttta 2400
tgaagtaaag ttaaaaacaa acataggaaa tgtgaaaata tttgtgtttg ttttgtctga 2460
ctaacttgct gctaaatgct atctttaggt gtgtgaaagt tctttgatat gttattgtcc 2520
ttttacatct tgttaaatag ccattgcttt tgagaatcag atagtgtgtt gtttaggggt 2580
taattgtgtc tatatctttc aaaaactttt atattatgta ttataagaag ttacagtagt 2640
accattttga ttagtctgaa tgttttcagg ccttgaaata aattttgact aagtgatatt 2700
ttttcttaaa aaaaaaaa 2718
<210> 13
<211> 2385
<212> DNA
<213> Homo sapiens
<400> 13
atggagtcgg ccgacttcta cgaggcggag ccgcggcccc cgatgagcag ccacctgcag 60
agccccccgc acgcgcccag cagcgccgcc ttcggctttc cccggggcgc gggccccgcg 120
cagcctcccg ccccacctgc cgccccggag ccgctgggcg gcatctgcga gcacgagacg 180
tccatcgaca tcagcgccta catcgacccg gccgccttca acgacgagtt cctggccgac 240
ctgttccagc acagccggca gcaggagaag gccaaggcgg ccgtgggccc cacgggcggc 300
ggcggcggcg gcgactttga ctacccgggc gcgcccgcgg gccccggcgg cgccgtcatg 360
cccgggggag cgcacgggcc cccgcccggc tacggctgcg cggccgccgg ctacctggac 420
ggcaggctgg agcccctgta cgagcgcgtc ggggcgccgg cgctgcggcc gctggtgatc 480
aagcaggagc cccgcgagga ggatgaagcc aagcagctgg cgctggccgg cctcttccct 540
taccagccgc cgccgccgcc gccgccctcg cacccgcacc cgcacccgcc gcccgcgcac 600
ctggccgccc cgcacctgca gttccagatc gcgcactgcg gccagaccac catgcacctg 660
cagcccggtc accccacgcc gccgcccacg cccgtgccca gcccgcaccc cgcgcccgcg 720
ctcggtgccg ccggcctgcc gggccctggc agcgcgctca aggggctggg cgccgcgcac 780
cccgacctcc gcgcgagtgg cggcagcggc gcgggcaagg ccaagaagtc ggtggacaag 840
aacagcaacg agtaccgggt gcggcgcgag cgcaacaaca tcgcggtgcg caagagccgc 900
gacaaggcca agcagcgcaa cgtggagacg cagcagaagg tgctggagct gaccagtgac 960
aatgaccgcc tgcgcaagcg ggtggaacag ctgagccgcg aactggacac gctgcggggc 1020
atcttccgcc agctgccaga gagctccttg gtcaaggcca tgggcaactg cgcgtgaggc 1080
gcgcggctgt gggaccgccc tgggccagcc tccggcgggg acccagggag tggtttgggg 1140
tcgccggatc tcgaggcttg cccgagccgt gcgagccagg actaggagat tccggtgcct 1200
cctgaaagcc tggcctgctc cgcgtgtccc ctcccttcct ctgcgccgga cttggtgcgt 1260
ctaagatgag ggggccaggc ggtggcttct ccctgcgagg aggggagaat tcttggggct 1320
gagctgggag cccggcaact ctagtattta ggataacctt gtgccttgga aatgcaaact 1380
caccgctcca atgcctactg agtaggggga gcaaatcgtg ccttgtcatt ttatttggag 1440
gtttcctgcc tccttcccga ggctacagca gacccccatg agagaaggag gggagcaggc 1500
ccgtggcagg aggagggctc agggagctga gatcccgaca agcccgccag ccccagccgc 1560
tcctccacgc ctgtccttag aaaggggtgg aaacataggg acttggggct tggaacctaa 1620
ggttgttccc ctagttctac atgaaggtgg agggtctcta gttccacgcc tctcccacct 1680
ccctccgcac acaccccacc ccagcctgct ataggctggg cttccccttg gggcggaact 1740
cactgcgatg ggggtcacca ggtgaccagt gggagccccc accccgagtc acaccagaaa 1800
gctaggtcgt gggtcagctc tgaggatgta tacccctggt gggagaggga gacctagaga 1860
tctggctgtg gggcgggcat ggggggtgaa gggccactgg gaccctcagc cttgtttgta 1920
ctgtatgcct tcagcattgc ctaggaacac gaagcacgat cagtccatcc cagagggacc 1980
ggagttatga caagctttcc aaatattttg ctttatcagc cgatatcaac acttgtatct 2040
ggcctctgtg ccccagcagt gccttgtgca atgtgaatgt gcgcgtctct gctaaaccac 2100
cattttattt ggtttttgtt ttgttttggt tttgctcgga tacttgccaa aatgagactc 2160
tccgtcggca gctgggggaa gggtctgaga ctccctttcc ttttggtttt gggattactt 2220
ttgatcctgg gggaccaatg aggtgagggg ggttctcctt tgccctcagc tttccccagc 2280
ccctccggcc tgggctgccc acaaggcttg tcccccagag gccctggctc ctggtcggga 2340
agggaggtgg cctcccgcca acgcatcact ggggctggga gcagg 2385
<210> 14
<211> 1908
<212> DNA
<213> Homo sapiens
<400> 14
gggacgtcag cggacggggc gctcgcgggc cggggctgta tggggctccc gcgcgggtcg 60
ttcttctggg tgctgctcct gctcacggct gcctgctcgg ggctcctctt tgccctgtac 120
ttctcggcgg tgcagcggta cccggggcca gcggccggag ccagggacac cacatcattt 180
gaagcattct ttcaatccaa ggcatcgaat tcttggacag gaaagggcca ggcctgccga 240
cacctgcttc acctggccat tcagcggcac ccccacttcc gtggcctgtt caatctctcc 300
attccagtgc tgctgtgggg ggacctcttc accccagcgc tctgggaccg cctgagccaa 360
cacaaagccc cgtatggctg gcgggggctc tctcaccaag tcatcgcctc caccctgagc 420
cttctgaacg gctcagagag tgccaagctg tttgccccgc ccagggacac ccctccaaag 480
tgtatccggt gtgccgtggt gggcaacgga ggcattctga atgggtcccg ccagggtccc 540
aacatcgatg cccatgacta tgtattcaga ctcaatggag ctgtgatcaa aggcttcgag 600
cgcgatgtgg gcaccaagac ttccttctat ggtttcactg tgaacacgat gaagaactcc 660
ctcgtctcct actggaatct gggcttcacc tccgtgccac aaggacagga cctgcagtat 720
atcttcatcc cctcagacat ccgcgactat gtgatgctga gatcggccat tctgggcgtg 780
cctgtccctg agggcctaga taaaggggac aggccgcacg cctattttgg accagaagcc 840
tctgccagta aattcaagct gctacatccg gacttcatca gctacctgac agaaaggttc 900
ttgaaatcaa agttgattaa cacacatttt ggagacctat atatgcctag taccggggct 960
ctcatgctgc tgacagcttt gcatacctgt gaccaggtca gtgcctatgg attcatcaca 1020
agcaactact ggaaattttc cgaccactat ttcgaacgaa aaatgaagcc attgatattt 1080
tatgcaaacc acgatctgtc cctggaagct gccctgtgga gggacctgca caaggccggc 1140
atccttcagc tgtaccagcg ctgaccccaa tgcactgagc gctttgcttc ttcaagagtt 1200
gcggccctga tcctctcaag tggccaaaag cttttttaac ttttcaatct tcaccttccc 1260
ttgccaacag agggcactgg ggtgaattca agattttcat cgaggtctgt tcaatatagg 1320
acaccccagc ttgtccttgg ctcatccaag aactcttctg tatctaaaac aatacatctc 1380
aatcttggcc aagggaaaat ggactgcttt gctggattgg cactgagcaa ctttaggaaa 1440
tgtcggtgga gtgttcagca agatcagaca gcagtccagg tcaaaggcaa acacacacgc 1500
tccagcccaa atcctcctgg tggcacatcc taccccagat gctaaagtga ttcaaggact 1560
ccaggacacc tcttaagagc ctttctaaga acatgatagg cttacttctg ctccataata 1620
aagtgggaga aaaaagccag aatataactt aagactagat aactgcgtac atgatggacc 1680
attttttttt tttttggctg ggtagagaaa tcatataaaa cgcaggctgt ttagcatgga 1740
gatgactctc agaacactgg gagggtctgg cacttgatgg gggttagttg cttggcagcc 1800
tgcctgccac tgagggaagt cccattagag atgtatcacc accttgtcac caacaggatg 1860
atgtcaccaa caggatgatg tcaccaggta ataaaccttc atcctcac 1908
<210> 15
<211> 2358
<212> DNA
<213> Homo sapiens
<400> 15
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca 60
gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc 120
ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc 180
cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg 240
ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc 300
cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg 360
acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg 420
acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga 480
tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca 540
gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg 600
gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga 660
ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc 720
aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc 780
caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga 840
cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga 900
agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga 960
agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg 1020
gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat 1080
gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg 1140
tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag 1200
acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc 1260
agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt 1320
ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa 1380
gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac 1440
actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat 1500
gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat 1560
cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat 1620
tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag 1680
ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat 1740
tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt 1800
ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg 1860
tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg 1920
tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct 1980
gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta 2040
tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga 2100
ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa 2160
tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc 2220
tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt 2280
gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta 2340
taaaaaaaaa aaaaaaaa 2358
<210> 16
<211> 2276
<212> DNA
<213> Homo sapiens
<400> 16
ctcattgaac tcgcctgcag ctcttgggtt ttttgtggct tccttcgtta ttggagccag 60
gcctacaccc cagcaaccat gtccaaggga cctgcagttg gtattgatct tggcaccacc 120
tactcttgtg tgggtgtttt ccagcacgga aaagtcgaga taattgccaa tgatcaggga 180
aaccgaacca ctccaagcta tgtcgccttt acggacactg aacggttgat cggtgatgcc 240
gcaaagaatc aagttgcaat gaaccccacc aacacagttt ttgatgccaa acgtctgatt 300
ggacgcagat ttgatgatgc tgttgtccag tctgatatga aacattggcc ctttatggtg 360
gtgaatgatg ctggcaggcc caaggtccaa gtagaataca agggagagac caaaagcttc 420
tatccagagg aggtgtcttc tatggttctg acaaagatga aggaaattgc agaagcctac 480
cttgggaaga ctgttaccaa tgctgtggtc acagtgccag cttactttaa tgactctcag 540
cgtcaggcta ccaaagatgc tggaactatt gctggtctca atgtacttag aattattaat 600
gagccaactg ctgctgctat tgcttacggc ttagacaaaa aggttggagc agaaagaaac 660
gtgctcatct ttgacctggg aggtggcact tttgatgtgt caatcctcac tattgaggat 720
ggaatctttg aggtcaagtc tacagctgga gacacccact tgggtggaga agattttgac 780
aaccgaatgg tcaaccattt tattgctgag tttaagcgca agcataagaa ggacatcagt 840
gagaacaaga gagctgtaag acgcctccgt actgcttgtg aacgtgctaa gcgtaccctc 900
tcttccagca cccaggccag tattgagatc gattctctct atgaaggaat cgacttctat 960
acctccatta cccgtgcccg atttgaagaa ctgaatgctg acctgttccg tggcaccctg 1020
gacccagtag agaaagccct tcgagatgcc aaactagaca agtcacagat tcatgatatt 1080
gtcctggttg gtggttctac tcgtatcccc aagattcaga agcttctcca agacttcttc 1140
aatggaaaag aactgaataa gagcatcaac cctgatgaag ctgttgctta tggtgcagct 1200
gtccaggcag ccatcttgtc tggagacaag tctgagaatg ttcaagattt gctgctcttg 1260
gatgtcactc ctctttccct tggtattgaa actgctggtg gagtcatgac tgtcctcatc 1320
aagcgtaata ccaccattcc taccaagcag acacagacct tcactaccta ttctgacaac 1380
cagcctggtg tgcttattca ggtttatgaa ggcgagcgtg ccatgacaaa ggataacaac 1440
ctgcttggca agtttgaact cacaggcata cctcctgcac cccgaggtgt tcctcagatt 1500
gaagtcactt ttgacattga tgccaatggt atactcaatg tctctgctgt ggacaagagt 1560
acgggaaaag agaacaagat tactatcact aatgacaagg gccgtttgag caaggaagac 1620
attgaacgta tggtccagga agctgagaag tacaaagctg aagatgagaa gcagagggac 1680
aaggtgtcat ccaagaattc acttgagtcc tatgccttca acatgaaagc aactgttgaa 1740
gatgagaaac ttcaaggcaa gattaacgat gaggacaaac agaagattct ggacaagtgt 1800
aatgaaatta tcaactggct tgataagaat cagactgctg agaaggaaga atttgaacat 1860
caacagaaag agctggagaa agtttgcaac cccatcatca ccaagctgta ccagagtgca 1920
ggaggcatgc caggaggaat gcctggggga tttcctggtg gtggagctcc tccctctggt 1980
ggtgcttcct cagggcccac cattgaagag gttgattaag ccaaccaagt gtagatgtag 2040
cattgttcca cacatttaaa acatttgaag gacctaaatt cgtagcaaat tctgtggcag 2100
ttttaaaaag ttaagctgct atagtaagtt actgggcatt ctcaatactt gaatatggaa 2160
catatgcaca ggggaaggaa ataacattgc actttataaa cactgtattg taagtggaaa 2220
atgcaatgtc ttaaataaaa ctatttaaaa ttggcaccat aaaaaaaaaa aaaaaa 2276
<210> 17
<211> 1817
<212> DNA
<213> Homo sapiens
<400> 17
ctcattgaac tcgcctgcag ctcttgggtt ttttgtggct tccttcgtta ttggagccag 60
gcctacaccc cagcaaccat gtccaaggga cctgcagttg gtattgatct tggcaccacc 120
tactcttgtg tgggtgtttt ccagcacgga aaagtcgaga taattgccaa tgatcaggga 180
aaccgaacca ctccaagcta tgtcgccttt acggacactg aacggttgat cggtgatgcc 240
gcaaagaatc aagttgcaat gaaccccacc aacacagttt ttgatgccaa acgtctgatt 300
ggacgcagat ttgatgatgc tgttgtccag tctgatatga aacattggcc ctttatggtg 360
gtgaatgatg ctggcaggcc caaggtccaa gtagaataca agggagagac caaaagcttc 420
tatccagagg aggtgtcttc tatggttctg acaaagatga aggaaattgc agaagcctac 480
cttgggaaga ctgttaccaa tgctgtggtc acagtgccag cttactttaa tgactctcag 540
cgtcaggcta ccaaagatgc tggaactatt gctggtctca atgtacttag aattattaat 600
gagccaactg ctgctgctat tgcttacggc ttagacaaaa aggttggagc agaaagaaac 660
gtgctcatct ttgacctggg aggtggcact tttgatgtgt caatcctcac tattgaggat 720
ggaatctttg aggtcaagtc tacagctgga gacacccact tgggtggaga agattttgac 780
aaccgaatgg tcaaccattt tattgctgag tttaagcgca agcataagaa ggacatcagt 840
gagaacaaga gagctgtaag acgcctccgt actgcttgtg aacgtgctaa gcgtaccctc 900
tcttccagca cccaggccag tattgagatc gattctctct atgaaggaat cgacttctat 960
acctccatta cccgtgcccg atttgaagaa ctgaatgctg acctgttccg tggcaccctg 1020
gacccagtag agaaagccct tcgagatgcc aaactagaca agtcacagat tcatgatatt 1080
gtcctggttg gtggttctac tcgtatcccc aagattcaga agcttctcca agacttcttc 1140
aatggaaaag aactgaataa gagcatcaac cctgatgaag ctgttgctta tggtgcagct 1200
gtccaggcag ccatcttgtc tggagacaag tctgagaatg ttcaagattt gctgctcttg 1260
gatgtcactc ctctttccct tggtattgaa actgctggtg gagtcatgac tgtcctcatc 1320
aagcgtaata ccaccattcc taccaagcag acacagacct tcactaccta ttctgacaac 1380
cagcctggtg tgcttattca ggtttatgaa ggcgagcgtg ccatgacaaa ggataacaac 1440
ctgcttggca agtttgaact cacaggcatg ccaggaggaa tgcctggggg atttcctggt 1500
ggtggagctc ctccctctgg tggtgcttcc tcagggccca ccattgaaga ggttgattaa 1560
gccaaccaag tgtagatgta gcattgttcc acacatttaa aacatttgaa ggacctaaat 1620
tcgtagcaaa ttctgtggca gttttaaaaa gttaagctgc tatagtaagt tactgggcat 1680
tctcaatact tgaatatgga acatatgcac aggggaagga aataacattg cactttataa 1740
acactgtatt gtaagtggaa aatgcaatgt cttaaataaa actatttaaa attggcacca 1800
taaaaaaaaa aaaaaaa 1817
<210> 18
<211> 6609
<212> DNA
<213> Homo sapiens
<400> 18
ttcttttaag gagtttgccg cgagcgcgtc tccttcattc gcaggctggg cgcgttcgca 60
gtcggctggc ggcgaaggaa ggcgctctcg ggacctcgcg ggcgcgcgtc ttttggctct 120
tgcccctgtc cctgcggctt ggggaaggcg taacccggcg gctaggcgcg ggagaagtgc 180
ggaggagcca tgggcgccgg gagctccacc gagcagcgca gcccggagca gccgcccgag 240
gggagctcca cgccggctga gcccgagccc agcggcggcg gcccctcggc cgaggcggcg 300
ccagacacca ccgcggaccc cgccatcgct gcctcggacc ccgccaccaa gctcctacag 360
aagaatggtc agctgtccac catcaatggc gtagctgagc aagatgagct cagcctccag 420
gagggtgacc taaatggcca gaaaggagcc ctgaacggtc aaggagccct aaacagccag 480
gaggaagaag aagtcattgt cacagaggtt ggacagagag actctgaaga tgtgagcaaa 540
agagactccg ataaagagat ggctactaag tcagcggttg ttcacgacat cacagatgat 600
gggcaggagg agacacccga aataatcgaa cagattcctt cttcagaaag caatttagaa 660
gagctaacac aacccactga gtcccaggct aatgatattg gatttaagaa ggtgtttaag 720
tttgttggct ttaaattcac tgtgaaaaag gataagacag agaagcctga cactgtccag 780
ctactcactg tgaagaaaga tgaaggggag ggagcagcag gggctggcga ccacaaggac 840
cccagccttg gggctggaga agcagcatcc aaagaaagcg aacccaaaca atctacagag 900
aaacccgaag agaccctgaa gcgtgagcaa agccacgcag aaatttctcc cccagccgaa 960
tctggccaag cagtggagga atgcaaagag gaaggagaag agaaacaaga aaaagaacct 1020
agcaagtctg cagaatctcc gactagtccc gtgaccagtg aaacaggatc aaccttcaaa 1080
aaattcttca ctcaaggttg ggccggctgg cgcaaaaaga ccagtttcag gaagccgaag 1140
gaggatgaag tggaagcttc agagaagaaa aaggaacaag agccagaaaa agtagacaca 1200
gaagaagacg gaaaggcaga ggttgcctcc gagaaactga ccgcctccga gcaagcccac 1260
ccacaggagc cggcagaaag tgcccacgag ccccggttat cagctgaata tgagaaagtt 1320
gagctgccct cagaggagca agtcagtggc tcgcagggac cttctgaaga gaaacctgct 1380
ccgttggcga cagaagtgtt tgatgagaaa atagaagtcc accaagaaga ggttgtggcc 1440
gaagtccacg tcagcaccgt ggaggagaga accgaagagc agaaaacgga ggtggaagaa 1500
acagcagggt ctgtgccagc tgaagaattg gttgaaatgg atgcagaacc tcaggaagct 1560
gaacctgcca aggagctggt gaagctcaaa gaaacgtgtg tttccggaga ggaccctaca 1620
cagggagctg acctcagtcc tgatgagaag gtgctgtcca aaccccccga aggcgttgtg 1680
agtgaggtgg aaatgctgtc atcacaggag agaatgaagg tgcagggaag tccactaaag 1740
aagcttttta ccagcactgg cttaaaaaag ctttctggaa agaaacagaa agggaaaaga 1800
ggaggaggag acgaggaatc aggggagcac actcaggttc cagccgattc tccggacagc 1860
caggaggagc aaaagggcga gagctctgcc tcatcccctg aggagcccga ggagatcacg 1920
tgtctggaaa agggcttagc cgaggtgcag caggatgggg aagctgaaga aggagctact 1980
tccgatggag agaaaaaaag agaaggtgtc actccctggg catcattcaa aaagatggtg 2040
acgcccaaga agcgtgttag acggccttcg gaaagtgata aagaagatga gctggacaag 2100
gtcaagagcg ctaccttgtc ttccaccgag agcacagcct ctgaaatgca agaagaaatg 2160
aaagggagcg tggaagagcc aaagccggaa gaaccaaagc gcaaggtgga tacctcagta 2220
tcttgggaag ctttaatttg tgtgggatca tccaagaaaa gagcaaggag agggtcctct 2280
tctgatgagg aagggggacc aaaagcaatg ggaggagacc accagaaagc tgatgaggcc 2340
ggaaaagaca aagagacggg gacagacggg atccttgctg gttcccaaga acatgatcca 2400
gggcagggaa gttcctcccc ggagcaagct ggaagcccta ccgaagggga gggcgtttcc 2460
acctgggagt catttaaaag gttagtcacg ccaagaaaaa aatcaaagtc caagctggaa 2520
gagaaaagcg aagactccat agctgggtct ggtgtagaac attccactcc agacactgaa 2580
cccggtaaag aagaatcctg ggtctcaatc aagaagttta ttcctggacg aaggaagaaa 2640
aggccagatg ggaaacaaga acaagcccct gttgaagacg cagggccaac aggggccaac 2700
gaagatgact ctgatgtccc ggccgtggtc cctctgtctg agtatgatgc tgtagaaagg 2760
gagaaaatgg aggcacagca agcccaaaaa agcgcagagc agcccgagca gaaggcagcc 2820
actgaggtgt ccaaggagct cagcgagagt caggttcata tgatggcagc agctgtcgct 2880
gacgggacga gggcagctac cattattgaa gaaaggtctc cttcttggat atctgcttca 2940
gtgacagaac ctcttgaaca agtagaagct gaagccgcac tgttaactga ggaggtattg 3000
gaaagagaag taattgcaga agaagaaccc cccacggtta ctgaacctct gccagagaac 3060
agagaggccc ggggcgacac ggtcgttagt gaggcggaat tgacccccga agctgtgaca 3120
gctgcagaaa ctgcagggcc attgggtgcc gaagaaggaa ccgaagcatc tgctgctgaa 3180
gagaccacag aaatggtgtc agcagtctcc cagttaaccg actccccaga caccacagag 3240
gaggccactc cggtgcagga ggtggaaggt ggcgtacctg acatagaaga gcaagagagg 3300
cggactcaag aggtcctcca ggcagtggca gaaaaagtga aagaggaatc ccagctgcct 3360
ggcaccggtg ggccagaaga tgtgcttcag cctgtgcaga gagcagaggc agaaagacca 3420
gaagagcagg ctgaagcgtc gggtctgaag aaagagacgg atgtagtgtt gaaagtagat 3480
gctcaggagg caaaaactga gccttttaca caagggaagg tggtggggca gaccacccca 3540
gaaagctttg aaaaagctcc tcaagtcaca gagagcatag agtccagtga gcttgtaacc 3600
acttgtcaag ccgaaacctt agctggggta aaatcacagg agatggtgat ggaacaggct 3660
atcccccctg actcggtgga aacccctaca gacagtgaga ctgatggaag cacccccgta 3720
gccgactttg acgcaccagg cacaacccag aaagacgaga ttgtggaaat ccatgaggag 3780
aatgaggtcg catctggtac ccagtcaggg ggcacagaag cagaggcagt tcctgcacag 3840
aaagagaggc ctccagcacc ttccagtttt gtgttccagg aagaaactaa agaacaatca 3900
aagatggaag acactctaga gcatacagat aaagaggtgt cagtggaaac tgtatccatt 3960
ctgtcaaaga ctgaggggac tcaagaggct gaccagtatg ctgatgagaa aaccaaagac 4020
gtaccatttt tcgaaggact tgaggggtct atagacacag gcataacagt cagtcgggaa 4080
aaggtcactg aagttgccct taaaggtgaa gggacagaag aagctgaatg taaaaaggat 4140
gatgctcttg aactgcagag tcacgctaag tctcctccat cccccgtgga gagagagatg 4200
gtagttcaag tcgaaaggga gaaaacagaa gcagagccaa cccatgtgaa tgaagagaag 4260
cttgagcacg aaacagctgt taccgtatct gaagaggtca gtaagcagct cctccagaca 4320
gtgaatgtgc ccatcataga tggggcaaag gaagtcagca gtttggaagg aagccctcct 4380
ccctgcctag gtcaagagga ggcagtatgc accaaaattc aagttcagag ctctgaggca 4440
tcattcactc taacagcggc tgcagaggag gaaaaggtct taggagaaac tgccaacatt 4500
ttagaaacag gtgaaacgtt ggagcctgca ggtgcacatt tagttctgga agagaaatcc 4560
tctgaaaaaa atgaagactt tgccgctcat ccaggggaag atgctgtgcc cacagggccc 4620
gactgtcagg caaaatcgac accagtgata gtatctgcta ctaccaagaa aggcttaagt 4680
tccgacctgg aaggagagaa aaccacatca ctgaagtgga agtcagatga agtcgatgag 4740
caggttgctt gccaggaggt caaagtgagt gtagcaattg aggatttaga gcctgaaaat 4800
gggattttgg aacttgagac caaaagcagt aaacttgtcc aaaacatcat ccagacagcc 4860
gttgaccagt ttgtacgtac agaagaaaca gccaccgaaa tgttgacgtc tgagttacag 4920
acacaagctc acgtgataaa agctgacagc caggacgctg gacaggaaac ggagaaagaa 4980
ggagaggaac ctcaggcctc tgcacaggat gaaacaccaa ttacttcagc caaagaggag 5040
tcagagtcaa ccgcagtggg acaagcacat tctgatattt ccaaagacat gagtgaagcc 5100
tcagaaaaga ccatgactgt tgaggtagaa ggttccactg taaatgatca gcagctggaa 5160
gaggtcgtcc tcccatctga ggaagaggga ggtggagctg gaacaaagtc tgtgccagaa 5220
gatgatggtc atgccttgtt agcagaaaga atagagaagt cactagttga accgaaagaa 5280
gatgaaaaag gtgatgatgt tgatgaccct gaaaaccaga actcagccct ggctgatact 5340
gatgcctcag gaggcttaac caaagagtcc ccagatacaa atggaccaaa acaaaaagag 5400
aaggaggatg cccaggaagt agaattgcag gaaggaaaag tgcacagtga atcagataaa 5460
gcgatcacac cccaagcaca ggaggagtta cagaaacaag agagagaatc tgcaaagtca 5520
gaacttacag aatcttaaaa catcatgcag ttaaactcat tgtctgtttg gaagaccaga 5580
atgtgaagac aagtagtaga agaaaatgaa tgctgctgct gagactgaag accagtattt 5640
cagaactttg agaattggag agcaggcaca tcaactgatc tcatttctag agagcccctg 5700
acaatcctga ggcttcatca ggagctagag ccatttaaca tttcctcttt ccaagaccaa 5760
cctacaattt tcccttgata accatataaa ttctgattta aggtcctaaa ttcttaacct 5820
ggaactggag ttggcaatac ctagttctgc ttctgaaact ggagtatcat tctttacata 5880
tttatatgta tgttttaagt agtcctcctg tatctattgt atattttttt cttaatgttt 5940
aaggaaatgt gcaggatact acatgctttt tgtatcacac agtatatgat ggggcatgtg 6000
ccatagtgca ggcttgggga gctttaagcc tcagttatat aacccacgaa aaacagagcc 6060
tcctagatgt aacattcctg atcaaggtac aattctttaa aattcactaa tgattgaggt 6120
ccatatttag tggtactctg aaattggtca ctttcctatt acacggagtg tgctaaaact 6180
aaaaagcatt ttgaaacata cagaatgttc tattgtcatt gggaaatttt tctttctaac 6240
ccagtggagg ttagaaagaa gttatattct ggtagcaaat taactttaca tcctttttcc 6300
tacttgttat ggttgtttgg accgataagt gtgcttaatc ctgaggcaaa gtagtgaata 6360
tgttttatat gttatgaaga aaagaattgt tgtaagtttt tgattctact cttatatgct 6420
ggactgcatt cacacatggc atgaaataag tcaggttctt tacaaatggt attttgatag 6480
atactggatt gtgtttgtgc catatttgtg ccattctttt aagaacaatg ttgcaacaca 6540
ttcatttgga taagttgtga tttgacgact gatttaaata aaatatttgc ttcacttaaa 6600
aaaaaaaaa 6609
<210> 19
<211> 6287
<212> DNA
<213> Homo sapiens
<400> 19
ggcagctccg agggcacctc cggttctccc ccatcctccg ggagtgtctg ggcgctcagt 60
ccgctctgat cccgccgaaa ccacctgcgg ttggcaggca ggagactagg cgtctgccgg 120
ggagggcagg gacccgctaa gctgatctcc tgtacagtag tgctacttaa aatatgctgg 180
ggaccatcac catcacagtt ggacagagag actctgaaga tgtgagcaaa agagactccg 240
ataaagagat ggctactaag tcagcggttg ttcacgacat cacagatgat gggcaggagg 300
agacacccga aataatcgaa cagattcctt cttcagaaag caatttagaa gagctaacac 360
aacccactga gtcccaggct aatgatattg gatttaagaa ggtgtttaag tttgttggct 420
ttaaattcac tgtgaaaaag gataagacag agaagcctga cactgtccag ctactcactg 480
tgaagaaaga tgaaggggag ggagcagcag gggctggcga ccacaaggac cccagccttg 540
gggctggaga agcagcatcc aaagaaagcg aacccaaaca atctacagag aaacccgaag 600
agaccctgaa gcgtgagcaa agccacgcag aaatttctcc cccagccgaa tctggccaag 660
cagtggagga atgcaaagag gaaggagaag agaaacaaga aaaagaacct agcaagtctg 720
cagaatctcc gactagtccc gtgaccagtg aaacaggatc aaccttcaaa aaattcttca 780
ctcaaggttg ggccggctgg cgcaaaaaga ccagtttcag gaagccgaag gaggatgaag 840
tggaagcttc agagaagaaa aaggaacaag agccagaaaa agtagacaca gaagaagacg 900
gaaaggcaga ggttgcctcc gagaaactga ccgcctccga gcaagcccac ccacaggagc 960
cggcagaaag tgcccacgag ccccggttat cagctgaata tgagaaagtt gagctgccct 1020
cagaggagca agtcagtggc tcgcagggac cttctgaaga gaaacctgct ccgttggcga 1080
cagaagtgtt tgatgagaaa atagaagtcc accaagaaga ggttgtggcc gaagtccacg 1140
tcagcaccgt ggaggagaga accgaagagc agaaaacgga ggtggaagaa acagcagggt 1200
ctgtgccagc tgaagaattg gttgaaatgg atgcagaacc tcaggaagct gaacctgcca 1260
aggagctggt gaagctcaaa gaaacgtgtg tttccggaga ggaccctaca cagggagctg 1320
acctcagtcc tgatgagaag gtgctgtcca aaccccccga aggcgttgtg agtgaggtgg 1380
aaatgctgtc atcacaggag agaatgaagg tgcagggaag tccactaaag aagcttttta 1440
ccagcactgg cttaaaaaag ctttctggaa agaaacagaa agggaaaaga ggaggaggag 1500
acgaggaatc aggggagcac actcaggttc cagccgattc tccggacagc caggaggagc 1560
aaaagggcga gagctctgcc tcatcccctg aggagcccga ggagatcacg tgtctggaaa 1620
agggcttagc cgaggtgcag caggatgggg aagctgaaga aggagctact tccgatggag 1680
agaaaaaaag agaaggtgtc actccctggg catcattcaa aaagatggtg acgcccaaga 1740
agcgtgttag acggccttcg gaaagtgata aagaagatga gctggacaag gtcaagagcg 1800
ctaccttgtc ttccaccgag agcacagcct ctgaaatgca agaagaaatg aaagggagcg 1860
tggaagagcc aaagccggaa gaaccaaagc gcaaggtgga tacctcagta tcttgggaag 1920
ctttaatttg tgtgggatca tccaagaaaa gagcaaggag agggtcctct tctgatgagg 1980
aagggggacc aaaagcaatg ggaggagacc accagaaagc tgatgaggcc ggaaaagaca 2040
aagagacggg gacagacggg atccttgctg gttcccaaga acatgatcca gggcagggaa 2100
gttcctcccc ggagcaagct ggaagcccta ccgaagggga gggcgtttcc acctgggagt 2160
catttaaaag gttagtcacg ccaagaaaaa aatcaaagtc caagctggaa gagaaaagcg 2220
aagactccat agctgggtct ggtgtagaac attccactcc agacactgaa cccggtaaag 2280
aagaatcctg ggtctcaatc aagaagttta ttcctggacg aaggaagaaa aggccagatg 2340
ggaaacaaga acaagcccct gttgaagacg cagggccaac aggggccaac gaagatgact 2400
ctgatgtccc ggccgtggtc cctctgtctg agtatgatgc tgtagaaagg gagaaaatgg 2460
aggcacagca agcccaaaaa agcgcagagc agcccgagca gaaggcagcc actgaggtgt 2520
ccaaggagct cagcgagagt caggttcata tgatggcagc agctgtcgct gacgggacga 2580
gggcagctac cattattgaa gaaaggtctc cttcttggat atctgcttca gtgacagaac 2640
ctcttgaaca agtagaagct gaagccgcac tgttaactga ggaggtattg gaaagagaag 2700
taattgcaga agaagaaccc cccacggtta ctgaacctct gccagagaac agagaggccc 2760
ggggcgacac ggtcgttagt gaggcggaat tgacccccga agctgtgaca gctgcagaaa 2820
ctgcagggcc attgggtgcc gaagaaggaa ccgaagcatc tgctgctgaa gagaccacag 2880
aaatggtgtc agcagtctcc cagttaaccg actccccaga caccacagag gaggccactc 2940
cggtgcagga ggtggaaggt ggcgtacctg acatagaaga gcaagagagg cggactcaag 3000
aggtcctcca ggcagtggca gaaaaagtga aagaggaatc ccagctgcct ggcaccggtg 3060
ggccagaaga tgtgcttcag cctgtgcaga gagcagaggc agaaagacca gaagagcagg 3120
ctgaagcgtc gggtctgaag aaagagacgg atgtagtgtt gaaagtagat gctcaggagg 3180
caaaaactga gccttttaca caagggaagg tggtggggca gaccacccca gaaagctttg 3240
aaaaagctcc tcaagtcaca gagagcatag agtccagtga gcttgtaacc acttgtcaag 3300
ccgaaacctt agctggggta aaatcacagg agatggtgat ggaacaggct atcccccctg 3360
actcggtgga aacccctaca gacagtgaga ctgatggaag cacccccgta gccgactttg 3420
acgcaccagg cacaacccag aaagacgaga ttgtggaaat ccatgaggag aatgaggtcg 3480
catctggtac ccagtcaggg ggcacagaag cagaggcagt tcctgcacag aaagagaggc 3540
ctccagcacc ttccagtttt gtgttccagg aagaaactaa agaacaatca aagatggaag 3600
acactctaga gcatacagat aaagaggtgt cagtggaaac tgtatccatt ctgtcaaaga 3660
ctgaggggac tcaagaggct gaccagtatg ctgatgagaa aaccaaagac gtaccatttt 3720
tcgaaggact tgaggggtct atagacacag gcataacagt cagtcgggaa aaggtcactg 3780
aagttgccct taaaggtgaa gggacagaag aagctgaatg taaaaaggat gatgctcttg 3840
aactgcagag tcacgctaag tctcctccat cccccgtgga gagagagatg gtagttcaag 3900
tcgaaaggga gaaaacagaa gcagagccaa cccatgtgaa tgaagagaag cttgagcacg 3960
aaacagctgt taccgtatct gaagaggtca gtaagcagct cctccagaca gtgaatgtgc 4020
ccatcataga tggggcaaag gaagtcagca gtttggaagg aagccctcct ccctgcctag 4080
gtcaagagga ggcagtatgc accaaaattc aagttcagag ctctgaggca tcattcactc 4140
taacagcggc tgcagaggag gaaaaggtct taggagaaac tgccaacatt ttagaaacag 4200
gtgaaacgtt ggagcctgca ggtgcacatt tagttctgga agagaaatcc tctgaaaaaa 4260
atgaagactt tgccgctcat ccaggggaag atgctgtgcc cacagggccc gactgtcagg 4320
caaaatcgac accagtgata gtatctgcta ctaccaagaa aggcttaagt tccgacctgg 4380
aaggagagaa aaccacatca ctgaagtgga agtcagatga agtcgatgag caggttgctt 4440
gccaggaggt caaagtgagt gtagcaattg aggatttaga gcctgaaaat gggattttgg 4500
aacttgagac caaaagcagt aaacttgtcc aaaacatcat ccagacagcc gttgaccagt 4560
ttgtacgtac agaagaaaca gccaccgaaa tgttgacgtc tgagttacag acacaagctc 4620
acgtgataaa agctgacagc caggacgctg gacaggaaac ggagaaagaa ggagaggaac 4680
ctcaggcctc tgcacaggat gaaacaccaa ttacttcagc caaagaggag tcagagtcaa 4740
ccgcagtggg acaagcacat tctgatattt ccaaagacat gagtgaagcc tcagaaaaga 4800
ccatgactgt tgaggtagaa ggttccactg taaatgatca gcagctggaa gaggtcgtcc 4860
tcccatctga ggaagaggga ggtggagctg gaacaaagtc tgtgccagaa gatgatggtc 4920
atgccttgtt agcagaaaga atagagaagt cactagttga accgaaagaa gatgaaaaag 4980
gtgatgatgt tgatgaccct gaaaaccaga actcagccct ggctgatact gatgcctcag 5040
gaggcttaac caaagagtcc ccagatacaa atggaccaaa acaaaaagag aaggaggatg 5100
cccaggaagt agaattgcag gaaggaaaag tgcacagtga atcagataaa gcgatcacac 5160
cccaagcaca ggaggagtta cagaaacaag agagagaatc tgcaaagtca gaacttacag 5220
aatcttaaaa catcatgcag ttaaactcat tgtctgtttg gaagaccaga atgtgaagac 5280
aagtagtaga agaaaatgaa tgctgctgct gagactgaag accagtattt cagaactttg 5340
agaattggag agcaggcaca tcaactgatc tcatttctag agagcccctg acaatcctga 5400
ggcttcatca ggagctagag ccatttaaca tttcctcttt ccaagaccaa cctacaattt 5460
tcccttgata accatataaa ttctgattta aggtcctaaa ttcttaacct ggaactggag 5520
ttggcaatac ctagttctgc ttctgaaact ggagtatcat tctttacata tttatatgta 5580
tgttttaagt agtcctcctg tatctattgt atattttttt cttaatgttt aaggaaatgt 5640
gcaggatact acatgctttt tgtatcacac agtatatgat ggggcatgtg ccatagtgca 5700
ggcttgggga gctttaagcc tcagttatat aacccacgaa aaacagagcc tcctagatgt 5760
aacattcctg atcaaggtac aattctttaa aattcactaa tgattgaggt ccatatttag 5820
tggtactctg aaattggtca ctttcctatt acacggagtg tgctaaaact aaaaagcatt 5880
ttgaaacata cagaatgttc tattgtcatt gggaaatttt tctttctaac ccagtggagg 5940
ttagaaagaa gttatattct ggtagcaaat taactttaca tcctttttcc tacttgttat 6000
ggttgtttgg accgataagt gtgcttaatc ctgaggcaaa gtagtgaata tgttttatat 6060
gttatgaaga aaagaattgt tgtaagtttt tgattctact cttatatgct ggactgcatt 6120
cacacatggc atgaaataag tcaggttctt tacaaatggt attttgatag atactggatt 6180
gtgtttgtgc catatttgtg ccattctttt aagaacaatg ttgcaacaca ttcatttgga 6240
taagttgtga tttgacgact gatttaaata aaatatttgc ttcactt 6287
<210> 20
<211> 3239
<212> DNA
<213> Homo sapiens
<400> 20
gggggtccgt tccccaactt cctcggcgct ccggactccc aagtctccgc cggaccctcc 60
tttggatatt cctcgtgtct ccgattctga gacagagggg gaagacggtg gggcctcccc 120
acctgccccg cagaagatgc agttctttgg ccgcctggtc aataccttca gtggcgtcac 180
caacttgttc tctaacccat tccgggtgaa ggaggtggct gtggccgact acacctcgag 240
tgaccgagtt cgggaggaag ggcagctgat tctgttccag aacactccca accgcacctg 300
ggactgcgtc ctggtcaacc ccaggaactc acagagtgga ttccgactct tccagctgga 360
gttggaggct gacgccctag tgaatttcca tcagtattct tcccagctgc tacccttcta 420
tgagagctcc cctcaggtcc tgcacactga ggtcctgcag cacctgaccg acctcatccg 480
taaccacccc agctggtcag tggcccacct ggctgtggag ctagggatcc gcgagtgctt 540
ccatcacagc cgtatcatca gctgtgccaa ttgcgcggag aacgaggagg gctgcacacc 600
cctgcacctg gcctgccgca agggtgatgg ggagatcctg gtggagctgg tgcagtactg 660
ccacactcag atggatgtca ccgactacaa gggagagacc gtcttccatt atgctgtcca 720
gggtgacaat tctcaggtgc tgcagctcct tggaaggaac gcagtggctg gcctgaacca 780
ggtgaataac caagggctga ccccgctgca cctggcctgc cagctgggga agcaggagat 840
ggtccgcgtg ctgctgctgt gcaatgctcg gtgcaacatc atgggcccca acggctaccc 900
catccactcg gccatgaagt tctctcagaa ggggtgtgcg gagatgatca tcagcatgga 960
cagcagccag atccacagca aagacccccg ttacggagcc agccccctcc actgggccaa 1020
gaacgcagag atggcccgca tgctgctgaa acggggctgc aacgtgaaca gcaccagctc 1080
cgcggggaac acggccctgc acgtggcggt gatgcgcaac cgcttcgact gtgccatagt 1140
gctgctgacc cacggggcca acgcggatgc ccgcggagag cacggcaaca ccccgctgca 1200
cctggccatg tcgaaagaca acgtggagat gatcaaggcc ctcatcgtgt tcggagcaga 1260
agtggacacc ccgaatgact ttggggagac tcctacattc ctagcctcca aaatcggcag 1320
acttgtcacc aggaaggcga tcttgactct gctgagaacc gtgggggccg aatactgctt 1380
cccacccatc cacggggtcc ccgcggagca gggctctgca gcgccacatc atcccttctc 1440
cctggaaaga gctcagcccc caccgatcag cctaaacaac ctagaactac aggatctcat 1500
gcacatctca cgggcccgga agccagcgtt catcctgggc tccatgaggg acgagaagcg 1560
gacccacgac cacctgctgt gcctggatgg aggaggagtg aaaggcctca tcatcatcca 1620
gctcctcatc gccatcgaga aggcctcggg tgtggccacc aaggacctgt ttgactgggt 1680
ggcgggcacc agcactggag gcatcctggc cctggccatt ctgcacagta agtccatggc 1740
ctacatgcgc ggcatgtact ttcgcatgaa ggatgaggtg ttccggggct ccaggcccta 1800
cgagtcgggg cccctggagg agttcctgaa gcgggagttt ggggagcaca ccaagatgac 1860
ggacgtcagg aaacccaagg tgatgctgac agggacactg tctgaccggc agccggctga 1920
actccacctc ttccggaact acgatgctcc agaaactgtc cgggagcctc gtttcaacca 1980
gaacgttaac ctcaggcctc cagctcagcc ctcagaccag ctggtgtggc gggcggcccg 2040
aagcagcggg gcagctccta cttacttccg acccaatggg cgcttcctgg acggtgggct 2100
gctggccaac aaccccacgc tggatgccat gaccgagatc catgagtaca atcaggacct 2160
gatccgcaag ggtcaggcca acaaggtgaa gaaactctcc atcgttgtct ccctggggac 2220
agggaggtcc ccacaagtgc ctgtgacctg tgtggatgtc ttccgtccca gcaacccctg 2280
ggagctggcc aagactgttt ttggggccaa ggaactgggc aagatggtgg tggactgttg 2340
cacggatcca gacgggcggg ctgtggaccg ggcacgggcc tggtgcgaga tggtcggcat 2400
ccagtacttc agattgaacc cccagctggg gacggacatc atgctggatg aggtcagtga 2460
cacagtgctg gtcaacgccc tctgggagac cgaggtctac atctatgagc accgcgagga 2520
gttccagaag ctcatccagc tgctgctctc accctgaggg tccccagcct ctcaccggcc 2580
ccagctgacc tcgtccattc agcccctgcc aggccaagcc cagccactgc cctcccgggc 2640
agatctgggc ccaggcacct ctgagtccat agaccaggcc tgggagaatg ccaagctgcc 2700
tgcccgaggc tggtcctgaa ggcctgtctc ccactaaccc cgccttccag cactttctgt 2760
cattccaggc tgggaaagtc tagagccccc tttggcccct ttccctgact gtcaaggaca 2820
actgactccc ccatcagctc aaacattaag ggtacccggg cacaaccgta cccctgcccc 2880
cagccccagc ctccctgagg gcctgccggg ctgcctctgc cccagccccc agcaagggca 2940
ctcccaggct tcctggtggg tgcagcccac tccctctgcc ctctgctccg ttccctgggg 3000
gctgggacta aagaaatggg tgtcccccac cccatcagct gggaaagccc aggccgcagg 3060
agtgggatgc ccgttggact ttgcccctca cactggccca gcccctcaca ctgccccacc 3120
ccgagaaccc tcagctctca aaggtcactc ctgggagttt cttcttccca atggaagtgg 3180
cttaagagcc aaaactgaaa taaatcattt ggattcaagt tcaaaaaaaa aaaaaaaaa 3239
<210> 21
<211> 3074
<212> DNA
<213> Homo sapiens
<400> 21
gggggtccgt tccccaactt cctcggcgct ccggactccc aagtctccgc cggaccctcc 60
tttggatatt cctcgtgtct ccgattctga gacagagggg gaagacggtg gggcctcccc 120
acctgccccg cagaagatgc agttctttgg ccgcctggtc aataccttca gtggcgtcac 180
caacttgttc tctaacccat tccgggtgaa ggaggtggct gtggccgact acacctcgag 240
tgaccgagtt cgggaggaag ggcagctgat tctgttccag aacactccca accgcacctg 300
ggactgcgtc ctggtcaacc ccaggaactc acagagtgga ttccgactct tccagctgga 360
gttggaggct gacgccctag tgaatttcca tcagtattct tcccagctgc tacccttcta 420
tgagagctcc cctcaggtcc tgcacactga ggtcctgcag cacctgaccg acctcatccg 480
taaccacccc agctggtcag tggcccacct ggctgtggag ctagggatcc gcgagtgctt 540
ccatcacagc cgtatcatca gctgtgccaa ttgcgcggag aacgaggagg gctgcacacc 600
cctgcacctg gcctgccgca agggtgatgg ggagatcctg gtggagctgg tgcagtactg 660
ccacactcag atggatgtca ccgactacaa gggagagacc gtcttccatt atgctgtcca 720
gggtgacaat tctcaggtgc tgcagctcct tggaaggaac gcagtggctg gcctgaacca 780
ggtgaataac caagggctga ccccgctgca cctggcctgc cagctgggga agcaggagat 840
ggtccgcgtg ctgctgctgt gcaatgctcg gtgcaacatc atgggcccca acggctaccc 900
catccactcg gccatgaagt tctctcagaa ggggtgtgcg gagatgatca tcagcatgga 960
cagcagccag atccacagca aagacccccg ttacggagcc agccccctcc actgggccaa 1020
gaacgcagag atggcccgca tgctgctgaa acggggctgc aacgtgaaca gcaccagctc 1080
cgcggggaac acggccctgc acgtggcggt gatgcgcaac cgcttcgact gtgccatagt 1140
gctgctgacc cacggggcca acgcggatgc ccgcggagag cacggcaaca ccccgctgca 1200
cctggccatg tcgaaagaca acgtggagat gatcaaggcc ctcatcgtgt tcggagcaga 1260
agtggacacc ccgaatgact ttggggagac tcctacattc ctagcctcca aaatcggcag 1320
acaactacag gatctcatgc acatctcacg ggcccggaag ccagcgttca tcctgggctc 1380
catgagggac gagaagcgga cccacgacca cctgctgtgc ctggatggag gaggagtgaa 1440
aggcctcatc atcatccagc tcctcatcgc catcgagaag gcctcgggtg tggccaccaa 1500
ggacctgttt gactgggtgg cgggcaccag cactggaggc atcctggccc tggccattct 1560
gcacagtaag tccatggcct acatgcgcgg catgtacttt cgcatgaagg atgaggtgtt 1620
ccggggctcc aggccctacg agtcggggcc cctggaggag ttcctgaagc gggagtttgg 1680
ggagcacacc aagatgacgg acgtcaggaa acccaaggtg atgctgacag ggacactgtc 1740
tgaccggcag ccggctgaac tccacctctt ccggaactac gatgctccag aaactgtccg 1800
ggagcctcgt ttcaaccaga acgttaacct caggcctcca gctcagccct cagaccagct 1860
ggtgtggcgg gcggcccgaa gcagcggggc agctcctact tacttccgac ccaatgggcg 1920
cttcctggac ggtgggctgc tggccaacaa ccccacgctg gatgccatga ccgagatcca 1980
tgagtacaat caggacctga tccgcaaggg tcaggccaac aaggtgaaga aactctccat 2040
cgttgtctcc ctggggacag ggaggtcccc acaagtgcct gtgacctgtg tggatgtctt 2100
ccgtcccagc aacccctggg agctggccaa gactgttttt ggggccaagg aactgggcaa 2160
gatggtggtg gactgttgca cggatccaga cgggcgggct gtggaccggg cacgggcctg 2220
gtgcgagatg gtcggcatcc agtacttcag attgaacccc cagctgggga cggacatcat 2280
gctggatgag gtcagtgaca cagtgctggt caacgccctc tgggagaccg aggtctacat 2340
ctatgagcac cgcgaggagt tccagaagct catccagctg ctgctctcac cctgagggtc 2400
cccagcctct caccggcccc agctgacctc gtccattcag cccctgccag gccaagccca 2460
gccactgccc tcccgggcag atctgggccc aggcacctct gagtccatag accaggcctg 2520
ggagaatgcc aagctgcctg cccgaggctg gtcctgaagg cctgtctccc actaaccccg 2580
ccttccagca ctttctgtca ttccaggctg ggaaagtcta gagccccctt tggccccttt 2640
ccctgactgt caaggacaac tgactccccc atcagctcaa acattaaggg tacccgggca 2700
caaccgtacc cctgccccca gccccagcct ccctgagggc ctgccgggct gcctctgccc 2760
cagcccccag caagggcact cccaggcttc ctggtgggtg cagcccactc cctctgccct 2820
ctgctccgtt ccctgggggc tgggactaaa gaaatgggtg tcccccaccc catcagctgg 2880
gaaagcccag gccgcaggag tgggatgccc gttggacttt gcccctcaca ctggcccagc 2940
ccctcacact gccccacccc gagaaccctc agctctcaaa ggtcactcct gggagtttct 3000
tcttcccaat ggaagtggct taagagccaa aactgaaata aatcatttgg attcaagttc 3060
aaaaaaaaaa aaaa 3074
<210> 22
<211> 1466
<212> DNA
<213> Homo sapiens
<400> 22
acaccacgaa cgcctgggac gcagctcctc cttccctggg gagccagccc ctctaccgct 60
ccagcctctc ccacctggga ccgcagcacc tgcccccagg atcctccacc tccggtgcag 120
tcagtgcctc cctccccagc ggtccctcaa gcagcccagg gagcgtccct gccactgtgc 180
ccatgcagat gccaaagccc agcagagtcc agcaggcgct cgcaggagcg accccgaagc 240
cagagccaga gccagagcag gtcataaaaa actacacgga agagctgaaa gtgcccccag 300
atgaggactg catcatctgc atggagaagc tgtccgcagc gtctggatac agcgatgtga 360
ctgacagcaa ggcaatcggg cccctggctg tgggctgcct caccaagtgc agccacgcct 420
tccacctgct gtgcctcctg gccatgtact gcaacggcaa taagggccct gagcacccca 480
atcccggaaa gccgttcact gccagagggt ttccccgcca gtgctacctt ccagacaacg 540
cccagggccg caagcctcca ggggcttcca gaacccggag acactggctg acattccggc 600
ctccccacag ctgctgaccg atggccacta catgacgctg cccgtgtctc cggaccagct 660
gccctgtgac gaccccatgg cgggcagcgg tggtgccccc gtgctgcggg tgggccatga 720
ccacggctgc caccagcagc ccttctgcaa cgcgcccctc cctggccctg gaccctatcg 780
tacagaacct gctaaggcca tcaaacctat tgatcggaag tcagtccatc agatttgctc 840
tgggccggtg gtactgagtc taagcactgg atgaagaaga tagtagaaaa cagtctggat 900
gctggtgcca ctaatgttga tctaaagctt aaggactatg gaatggatct cattgaagtt 960
tcaggcaatg gatgtggggt agaagaagaa aacttcgaag gcttaatgat gtcaccattt 1020
ctacctgcca cgtatcggcg aaggttggga ctcgactggt gtttgatcac gatgggaaaa 1080
tcatccagaa aaccccctac ccccacccca gagggaccac agtcagcgtg aagcagttat 1140
tttctacgct acctgtgcgc cataaggaat ttcaaaggaa tattaagaag aaacgtgcct 1200
gcttcccctt cgccttctgc cgtgattgtc agcttcttga gggctcccca gccatgcttc 1260
ctgtacagcc tgcaaaactg actcctagaa gtaccccacc ccacccctgc tccttggagg 1320
acaacgtgat cactgtattc agctccatca agaatggtcc aggttcttct agatgatctg 1380
cacaaatggt tcctctcctc cttcctgatg tctgccatta gcattggaat aaagttcctg 1440
ctgaaaaaaa aaaaaaaaaa aaaaaa 1466
<210> 23
<211> 6116
<212> DNA
<213> Homo sapiens
<400> 23
ctccgactct cggcacctgg cctccagctt tcggaactat ggaggccgcg cccgggaccc 60
ccccgccgcc gccatcagag tcgccgccgc cgccatcgcc gccgccgcca tcaacgcctt 120
cgcctcctcc gtgttccccc gacgcccgcc cggccacccc gcacctcctc caccaccgcc 180
tcccgctccc tgacgacagg gaagatggag agttggaaga aggtgaattg gaagatgatg 240
gggcagagga gacccaggat acctccggag ggcctgagag aagccggaaa gaaaaggggg 300
agaagcatca cagtgattcg gatgaggaga agtcccacag gagactgaag cggaaacgga 360
agaaagagcg ggagaaagag aaaaggaggt cgaagaagag gaggaaatcc aagcacaaac 420
gccatgcttc ttctagcgat gacttctctg acttctcaga tgactcggat ttcagcccca 480
gtgagaaagg tcaccgcaag tacagagagt acagcccccc atatgcgccg tcccaccagc 540
agtacccccc atcgcatgcc acgcccctgc ccaagaaggc atactccaag atggacagca 600
agagttatgg catgtacgag gactacgaga atgagcagta tggggaatat gagggcgacg 660
aggaggagga catgggcaag gaggactatg acgacttcac caaagagctg aaccagtacc 720
ggcgtgccaa ggagggcagc agccgcggcc gaggcagccg aggccggggc cggggctaca 780
ggggccgagg aagccgtgga ggatcgcgag gccgcggcat gggcaggggc agccgaggca 840
ggggcagagg ctctatggga ggagaccacc cggaggatga agaggatttc tacgaggaag 900
agatggacta tggagagagt gaggagccaa tgggagacga cgactatgac gagtactcca 960
aggagctgaa ccagtaccgc cgctccaagg acagccgagg ccgagggcta agtcgaggcc 1020
gtggcagggg ctcccgaggt cgagggaaag gaatgggtcg gggccgaggc cgaggtggca 1080
gccgaggagg gatgaacaag ggcggaatga acgatgacga agacttctat gacgaggaca 1140
tgggcgacgg tggtggtgga agctaccgga gtcgtgacca tgacaagccc caccagcagt 1200
cggacaagaa aggcaaagtc atttgcaagt acttcgtgga agggcgctgc acctggggag 1260
accactgtaa ttttagccat gacatcgaac tcccaaagaa gcgagaactg tgcaagtttt 1320
acatcactgg attttgcgcc agagctgaga actgccctta tatgcacggt gatttcccgt 1380
gtaagctgta ccacaccact gggaactgca tcaatggtga cgactgcatg ttttcccacg 1440
accctctgac cgaagagacg agggagctct tggataagat gttggccgat gatgcagaag 1500
caggtgccga ggatgagaag gaggtggagg aactgaagaa gcagggcatc aaccccctgc 1560
ccaaaccgcc ccctggtgtg ggcctcctgc ccacccctcc tcggccccct ggcccgcagg 1620
ctccaacctc tcccaacggc aggcccatgc agggtggccc cccgcccccg ccccctcccc 1680
ctcccccacc gcccgggccc cctcagatgc ccatgccggt gcatgagcca ctgtccccgc 1740
agcagctgca gcagcaggac atgtacaaca agaagatccc ctccttgttt gagatcgtgg 1800
tgcggcccac gggacagctg gctgagaagc tgggtgtgag gttccctgga cccggtggac 1860
ccccagggcc aatgggccct gggcccaaca tgggaccccc agggccaatg ggcggtccaa 1920
tgcatcctga catgcacccc gacatgcacc cggacatgca ccctgacatg cacgcagaca 1980
tgcacgcaga catgccgatg ggccctggca tgaatcctgg cccacccatg ggccctggcg 2040
gccctccaat gatgccctac ggccctggag actccccaca ttctggaatg atgcccccta 2100
tcccgccagc ccagaacttc tatgaaaact tctaccagca gcaggagggc atggagatgg 2160
agcccggact cctgggggat gcagaggact acgggcacta cgaagagctg ccaggggagc 2220
ctggggagca cctcttccct gagcaccctc tggagcccga cagcttctct gagggagggc 2280
ccccaggccg gccgaagcca ggcgccggtg tccctgactt cctgccctca gcccagaggg 2340
ccctgtacct gaggatccag cagaagcagc aggaggagga ggagagagcg aggaggctgg 2400
ctgagagcag caagcaggac cgggagaatg aggaaggtga caccggaaac tggtactcaa 2460
gtgatgagga tgagggtgga agcagtgtca cctccatcct gaagaccttg aggcagcaga 2520
cgtccagccg acccccggct tcagttgggg agctgagcag cagtgggctg ggggaccccc 2580
gcctccagaa gggacacccc acaggaagcc ggctggctga ccctcgcctc agccgggacc 2640
ccagactcac ccgccatgtg gaggcttctg gcgggtctgg cccaggtgat tcgggaccct 2700
ccgatcctcg gctggctcgc gccctgccca cctccaagcc cgaaggcagc cttcattcca 2760
gccctgtggg ccccagcagt tccaaggggt ctgggccgcc cccaacggag gaggaggaag 2820
gggagcgggc cctgcgggag aaggccgtga acattcccct ggacccactc cccgggcacc 2880
ctctgcggga cccacggtca cagctgcagc agttcagcca catcaagaag gacgtgaccc 2940
tgagcaagcc cagcttcgcc cgcaccgtgc tctggaatcc cgaggacctg atccccctac 3000
ccatccccaa gcaggacgca gtgccccccg tgcccgcggc cctgcaatcc atgcccaccc 3060
tggacccccg gctgcaccgc gctgccacgg cagggccccc caacgcccgg cagcgcccgg 3120
gcgcctccac ggattccagc acacagggcg ccaacctccc cgactttgaa cttctgtctc 3180
gcatcctcaa gacagtcaat gccaccggct cctcggccgc ccccggttcc agcgacaaac 3240
ccagtgaccc ccgggtgcgg aaggccccca ccgaccctcg gctgcagaaa cccacagact 3300
ctacggcctc ctcccgggct gccaagcccg gccctgctga ggcgccctct cccaccgcca 3360
gcccgagtgg ggatgcctcc ccaccagcca ccgctcccta cgacccccgc gtgctggcgg 3420
ccggtggact gggccagggc ggagggggcg ggcagagcag tgtgctgagc ggtatcagcc 3480
tctacgaccc gaggactccc aacgcggggg gcaaagccac agagccggct gctgacacgg 3540
gtgcccagcc caagggtgct gagggcaatg gcaagagctc ggcctccaag gctaaggagc 3600
ccccgttcgt ccgcaagtct gccctggaac agccagagac agggaaggcc ggtgctgatg 3660
ggggcacccc cacggacaga tacaacagct acaaccggcc ccggcccaag gctgctgcag 3720
cccccgctgc caccaccgcc accccacccc ccgagggtgc cccaccccag cccggggtgc 3780
acaacctgcc cgtgcccacc ctcttcggga cggtgaagca gacacccaag acgggctcag 3840
gaagcccatt tgctgggaac agtccggccc gcgagggtga gcaggatgcg gcatccctga 3900
aggatgtttt taaaggcttc gaccccacgg cctccccctt ttgccagtag tgtccagcca 3960
gagctgcggc tccagccacc cttcctaggg tggcattcag ggcagcaccc agggtaggga 4020
acttgggggc aaggggaggc aggctgggtg ttcctttttt cttttctttt tcttttgctt 4080
tccgtctctt ttattttttt ttaaagtagt actttctttg agatttgtaa attgtatata 4140
accatcttaa gttctggtca gtgtggcggg ctcaggggct cctgctgagc aaaccgactc 4200
atgcccgcaa acctgtgaac tttcgccagt gcctggcctc agactctgtg ggctctgcgt 4260
ggccgggcct tgctggaggc ccagtgggtt ttctgggcaa agcatggccc cttttcccca 4320
ggacaaaggg aacagttggt gtctgggaag gtattgaacg ctcctcaccc tgtgcccgaa 4380
gagacccgga accaagacca tggcagggcc tgcgtggaag caggtccagg cgtttctaga 4440
accctagggt gcaccatcac tgtcttttca gtgcaggctg taacaaccca ctcaggagac 4500
agtgagagtg aaaaggtatt aaggaaaaag cccccagcgg cactatgggg gctccctggc 4560
gcatgcctgc tcctgtccct ggattaccac acgtgccctc cctgccaccc tccgtctaga 4620
gcaagcggat gccccccagc ctgcagcaga agcctccaca gtgagaactg gacccaaagg 4680
tagtgggggc cggtgtgggg cagagtcctg aagagccacc tctaggaggc agcccctagg 4740
agcacgcacg ttctgtcagt attaccccac ctgtcctatc aggtgggcca caccctgctt 4800
gcccacacca gggtctgtcc tggtcctcaa gccacgcacc cgctatgcct gcactgcagc 4860
ccagccccgg acagctccag gatccgtgca gtggctgcgc cgccaggccc caacaatggg 4920
gaccctgggg tggctcctgg ccaagtgttc tctgttttcc tcgcacctcc ttacactgtg 4980
tgacctgcag ggcatgaggt attgatgtgt tcgggtttcc tttcccaagc cagcagatgc 5040
aggtgttcca aggtgtgttg ctctgtggga tttgtggaca cttaagaaac ggactgagtg 5100
ggaaccctgc agccagggga tggggagcct ctgctccccc catgctccca ccctggctga 5160
gggccagcct catctgcaga gccctggagg aggcccacct atggacacag cccgagagat 5220
gggcgcaagg ggtgctgggg gaggcctgct atcctgcctc tgggccactt gaggggcctc 5280
aggaagtgtg tgcttgtggc tgcatctgcc cgtctccctg gcccaccatg tggctgcagg 5340
ccaagctctt cattgctgac catgaagaga cctagttacc tgccaaggga ttccccttcc 5400
ctcctcctca gggtggggtg aacaaggctc ctatcccacc ccaccccaaa aagagaaaaa 5460
tgaaaaactc atagtttgga gccaggaggc agggtgtcct acagggctgc acagccctga 5520
ggggtcagtg ctgggatctg gttggttggt ttgtcttttt gtcttttttt tttttttttt 5580
ttttacacaa tcattaatga gatttgtctt cagccaccag tgttggcctt gaagcagagg 5640
gcacagccct tggtgtttgt aaaataagta tgaatacaca gtgtggcagt gttgtggttt 5700
ttgttgttgt ttttcctctc cttttgagaa ttttcttttg taaaagaaaa atatttttta 5760
aaccgaaatc tgtggatgaa atagaagctg gagccctcct cttggaatat tcagcctaag 5820
aacctcatag gactatgaat tcacccgaaa ttctcatttg ccatcaggcc gagcttttaa 5880
agaaaaattg ttctctaacc aggattgtaa caaaagtgta aatactgttt cagagttgag 5940
agttggtggt gcaaatatgt atataatgaa ctgtattttt acaatgatcg ccgcatgact 6000
atttcacacc ctttttatac tccatatctg tcttccagaa acgtcacctg cctttctcct 6060
gtggtctctt aatccagtaa ttgtattact gccattaaag gatgcagtta ttttaa 6116
<210> 24
<211> 6116
<212> DNA
<213> Homo sapiens
<400> 24
ctccgactct cggcacctgg cctccagctt tcggaactat ggaggccgcg cccgggaccc 60
ccccgccgcc gccatcagag tcgccgccgc cgccatcgcc gccgccgcca tcaacgcctt 120
cgcctcctcc gtgttccccc gacgcccgcc cggccacccc gcacctcctc caccaccgcc 180
tcccgctccc tgacgacagg gaagatggag agttggaaga aggtgaattg gaagatgatg 240
gggcagagga gacccaggat acctccggag ggcctgagag aagccggaaa gaaaaggggg 300
agaagcatca cagtgattcg gatgaggaga agtcccacag gagactgaag cggaaacgga 360
agaaagagcg ggagaaagag aaaaggaggt cgaagaagag gaggaaatcc aagcacaaac 420
gccatgcttc ttctagcgat gacttctctg acttctcaga tgactcggat ttcagcccca 480
gtgagaaagg tcaccgcaag tacagagagt acagcccccc atatgcgccg tcccaccagc 540
agtacccccc atcgcatgcc acgcccctgc ccaagaaggc atactccaag atggacagca 600
agagttatgg catgtacgag gactacgaga atgagcagta tggggaatat gagggcgacg 660
aggaggagga catgggcaag gaggactatg acgacttcac caaagagctg aaccagtacc 720
ggcgtgccaa ggagggcagc agccgcggcc gaggcagccg aggccggggc cggggctaca 780
ggggccgagg aagccgtgga ggatcgcgag gccgcggcat gggcaggggc agccgaggca 840
ggggcagagg ctctatggga ggagaccacc cggaggatga agaggatttc tacgaggaag 900
agatggacta tggagagagt gaggagccaa tgggagacga cgactatgac gagtactcca 960
aggagctgaa ccagtaccgc cgctccaagg acagccgagg ccgagggcta agtcgaggcc 1020
gtggcagggg ctcccgaggt cgagggaaag gaatgggtcg gggccgaggc cgaggtggca 1080
gccgaggagg gatgaacaag ggcggaatga acgatgacga agacttctat gacgaggaca 1140
tgggcgacgg tggtggtgga agctaccgga gtcgtgacca tgacaagccc caccagcagt 1200
cggacaagaa aggcaaagtc atttgcaagt acttcgtgga agggcgctgc acctggggag 1260
accactgtaa ttttagccat gacatcgaac tcccaaagaa gcgagaactg tgcaagtttt 1320
acatcactgg attttgcgcc agagctgaga actgccctta tatgcacggt gatttcccgt 1380
gtaagctgta ccacaccact gggaactgca tcaatggtga cgactgcatg ttttcccacg 1440
accctctgac cgaagagacg agggagctct tggataagat gttggccgat gatgcagaag 1500
caggtgccga ggatgagaag gaggtggagg aactgaagaa gcagggcatc aaccccctgc 1560
ccaaaccgcc ccctggtgtg ggcctcctgc ccacccctcc tcggccccct ggcccgcagg 1620
ctccaacctc tcccaacggc aggcccatgc agggtggccc cccgcccccg ccccctcccc 1680
ctcccccacc gcccgggccc cctcagatgc ccatgccggt gcatgagcca ctgtccccgc 1740
agcagctgca gcagcaggac atgtacaaca agaagatccc ctccttgttt gagatcgtgg 1800
tgcggcccac gggacagctg gctgagaagc tgggtgtgag gttccctgga cccggtggac 1860
ccccagggcc aatgggccct gggcccaaca tgggaccccc agggccaatg ggcggtccaa 1920
tgcatcctga catgcacccc gacatgcacc cggacatgca ccctgacatg cacgcagaca 1980
tgcacgcaga catgccgatg ggccctggca tgaatcctgg cccacccatg ggccctggcg 2040
gccctccaat gatgccctac ggccctggag actccccaca ttctggaatg atgcccccta 2100
tcccgccagc ccagaacttc tatgaaaact tctaccagca gcaggagggc atggagatgg 2160
agcccggact cctgggggat gcagaggact acgggcacta cgaagagctg ccaggggagc 2220
ctggggagca cctcttccct gagcaccctc tggagcccga cagcttctct gagggagggc 2280
ccccaggccg gccgaagcca ggcgccggtg tccctgactt cctgccctca gcccagaggg 2340
ccctgtacct gaggatccag cagaagcagc aggaggagga ggagagagcg aggaggctgg 2400
ctgagagcag caagcaggac cgggagaatg aggaaggtga caccggaaac tggtactcaa 2460
gtgatgagga tgagggtgga agcagtgtca cctccatcct gaagaccttg aggcagcaga 2520
cgtccagccg acccccggct tcagttgggg agctgagcag cagtgggctg ggggaccccc 2580
gcctccagaa gggacacccc acaggaagcc ggctggctga ccctcgcctc agccgggacc 2640
ccagactcac ccgccatgtg gaggcttctg gcgggtctgg cccaggtgat tcgggaccct 2700
ccgatcctcg gctggctcgc gccctgccca cctccaagcc cgaaggcagc cttcattcca 2760
gccctgtggg ccccagcagt tccaaggggt ctgggccgcc cccaacggag gaggaggaag 2820
gggagcgggc cctgcgggag aaggccgtga acattcccct ggacccactc cccgggcacc 2880
ctctgcggga cccacggtca cagctgcagc agttcagcca catcaagaag gacgtgaccc 2940
tgagcaagcc cagcttcgcc cgcaccgtgc tctggaatcc cgaggacctg atccccctac 3000
ccatccccaa gcaggacgca gtgccccccg tgcccgcggc cctgcaatcc atgcccaccc 3060
tggacccccg gctgcaccgc gctgccacgg cagggccccc caacgcccgg cagcgcccgg 3120
gcgcctccac ggattccagc acacagggcg ccaacctccc cgactttgaa cttctgtctc 3180
gcatcctcaa gacagtcaat gccaccggct cctcggccgc ccccggttcc agcgacaaac 3240
ccagtgaccc ccgggtgcgg aaggccccca ccgaccctcg gctgcagaaa cccacagact 3300
ctacggcctc ctcccgggct gccaagcccg gccctgctga ggcgccctct cccaccgcca 3360
gcccgagtgg ggatgcctcc ccaccagcca ccgctcccta cgacccccgc gtgctggcgg 3420
ccggtggact gggccagggc ggagggggcg ggcagagcag tgtgctgagc ggtatcagcc 3480
tctacgaccc gaggactccc aacgcggggg gcaaagccac agagccggct gctgacacgg 3540
gtgcccagcc caagggtgct gagggcaatg gcaagagctc ggcctccaag gctaaggagc 3600
ccccgttcgt ccgcaagtct gccctggaac agccagagac agggaaggcc ggtgctgatg 3660
ggggcacccc cacggacaga tacaacagct acaaccggcc ccggcccaag gctgctgcag 3720
cccccgctgc caccaccgcc accccacccc ccgagggtgc cccaccccag cccggggtgc 3780
acaacctgcc cgtgcccacc ctcttcggga cggtgaagca gacacccaag acgggctcag 3840
gaagcccatt tgctgggaac agtccggccc gcgagggtga gcaggatgcg gcatccctga 3900
aggatgtttt taaaggcttc gaccccacgg cctccccctt ttgccagtag tgtccagcca 3960
gagctgcggc tccagccacc cttcctaggg tggcattcag ggcagcaccc agggtaggga 4020
acttgggggc aaggggaggc aggctgggtg ttcctttttt cttttctttt tcttttgctt 4080
tccgtctctt ttattttttt ttaaagtagt actttctttg agatttgtaa attgtatata 4140
accatcttaa gttctggtca gtgtggcggg ctcaggggct cctgctgagc aaaccgactc 4200
atgcccgcaa acctgtgaac tttcgccagt gcctggcctc agactctgtg ggctctgcgt 4260
ggccgggcct tgctggaggc ccagtgggtt ttctgggcaa agcatggccc cttttcccca 4320
ggacaaaggg aacagttggt gtctgggaag gtattgaacg ctcctcaccc tgtgcccgaa 4380
gagacccgga accaagacca tggcagggcc tgcgtggaag caggtccagg cgtttctaga 4440
accctagggt gcaccatcac tgtcttttca gtgcaggctg taacaaccca ctcaggagac 4500
agtgagagtg aaaaggtatt aaggaaaaag cccccagcgg cactatgggg gctccctggc 4560
gcatgcctgc tcctgtccct ggattaccac acgtgccctc cctgccaccc tccgtctaga 4620
gcaagcggat gccccccagc ctgcagcaga agcctccaca gtgagaactg gacccaaagg 4680
tagtgggggc cggtgtgggg cagagtcctg aagagccacc tctaggaggc agcccctagg 4740
agcacgcacg ttctgtcagt attaccccac ctgtcctatc aggtgggcca caccctgctt 4800
gcccacacca gggtctgtcc tggtcctcaa gccacgcacc cgctatgcct gcactgcagc 4860
ccagccccgg acagctccag gatccgtgca gtggctgcgc cgccaggccc caacaatggg 4920
gaccctgggg tggctcctgg ccaagtgttc tctgttttcc tcgcacctcc ttacactgtg 4980
tgacctgcag ggcatgaggt attgatgtgt tcgggtttcc tttcccaagc cagcagatgc 5040
aggtgttcca aggtgtgttg ctctgtggga tttgtggaca cttaagaaac ggactgagtg 5100
ggaaccctgc agccagggga tggggagcct ctgctccccc catgctccca ccctggctga 5160
gggccagcct catctgcaga gccctggagg aggcccacct atggacacag cccgagagat 5220
gggcgcaagg ggtgctgggg gaggcctgct atcctgcctc tgggccactt gaggggcctc 5280
aggaagtgtg tgcttgtggc tgcatctgcc cgtctccctg gcccaccatg tggctgcagg 5340
ccaagctctt cattgctgac catgaagaga cctagttacc tgccaaggga ttccccttcc 5400
ctcctcctca gggtggggtg aacaaggctc ctatcccacc ccaccccaaa aagagaaaaa 5460
tgaaaaactc atagtttgga gccaggaggc agggtgtcct acagggctgc acagccctga 5520
ggggtcagtg ctgggatctg gttggttggt ttgtcttttt gtcttttttt tttttttttt 5580
ttttacacaa tcattaatga gatttgtctt cagccaccag tgttggcctt gaagcagagg 5640
gcacagccct tggtgtttgt aaaataagta tgaatacaca gtgtggcagt gttgtggttt 5700
ttgttgttgt ttttcctctc cttttgagaa ttttcttttg taaaagaaaa atatttttta 5760
aaccgaaatc tgtggatgaa atagaagctg gagccctcct cttggaatat tcagcctaag 5820
aacctcatag gactatgaat tcacccgaaa ttctcatttg ccatcaggcc gagcttttaa 5880
agaaaaattg ttctctaacc aggattgtaa caaaagtgta aatactgttt cagagttgag 5940
agttggtggt gcaaatatgt atataatgaa ctgtattttt acaatgatcg ccgcatgact 6000
atttcacacc ctttttatac tccatatctg tcttccagaa acgtcacctg cctttctcct 6060
gtggtctctt aatccagtaa ttgtattact gccattaaag gatgcagtta ttttaa 6116
<210> 25
<211> 4805
<212> DNA
<213> Homo sapiens
<400> 25
gttaagttgg agccgactca gcggcggccg ccattttgtg cagtcgctgg gaaggaagga 60
gacgcctaaa ccgcggcact gcccggtttg agcgtagcca aacctgccca ccggctttgt 120
agccccgatt ctctgtgttt tgctcccgtc tccgacgaga gaggcggcga cggtggcgtc 180
tgcgacggga gacagcgcgt cggagcgaga gagcgctgcg cctgccgccg ccccaacagc 240
ggaggcgccg ccgccatcgg tcgtcaccag accggagccg caggccctcc cgagcccggc 300
catccgtgcc ccgctcccag atctctatcc ttttgggacc atgcgcggag gaggctttgg 360
ggaccgggac cgggatcgtg accgtggagg atttggagca agaggtggtg gtggccttcc 420
cccgaagaaa tttggtaatc ctggggagcg tttgcgtaaa aaaaagtggg atttgagtga 480
gctccccaag tttgagaaaa atttttatgt ggaacatccg gaagtagcaa ggctgacacc 540
atatgaggtt gatgagctac gccgaaagaa ggagattaca gtgagggggg gagatgtttg 600
tcctaaaccc gtgtttgcct tccatcatgc taacttccca caatatgtaa tggatgtgtt 660
gatggatcag cactttacag aaccaactcc aattcagtgc cagggatttc cgttggctct 720
tagtggccgg gatatggtgg gcattgctca gactggctct gggaagacgt tggcgtatct 780
cctgcctgca attgttcata ttaaccacca gccatacttg gaaaggggag atggcccaat 840
ctgtctagtt ctggctccta ccagagagct tgcccagcaa gtacagcagg tggccgatga 900
ctatggcaaa tgttctagat tgaagagtac ttgtatttat ggaggtgctc ctaaaggtcc 960
ccagattcga gacttggaaa gaggtgttga gatctgcata gccactcctg gacgtctgat 1020
agatttcctg gagtcaggaa agacaaatct tcgccgatgt acttaccttg tattggacga 1080
agctgacaga atgcttgata tggggtttga accccagatc cgtaaaattg ttgaccaaat 1140
caggcctgat aggcagacac tgatgtggag tgcaacctgg ccaaaagaag taagacagct 1200
tgcagaggat ttccttcgtg attacaccca gatcaacgta ggcaatctgg agttgagtgc 1260
caaccacaac atcctccaga tagtggatgt ctgcatggaa agtgaaaaag accacaagtt 1320
gatccaacta atggaagaaa taatggctga aaaggaaaac aaaacaataa tatttgtgga 1380
gacaaagaga cgctgtgatg atctgactcg aaggatgcgc agagatggtt ggccagctat 1440
gtgtatccat ggagacaaga gtcaaccaga aagagattgg gtacttaatg agttccgttc 1500
tggaaaggca cccatcctta ttgctacaga tgtagcctcc cgtgggctag atgtggaaga 1560
tgtcaagttt gtgatcaact atgactatcc aaacagctca gaggattatg tgcaccgtat 1620
tggccgaaca gcccgtagca ccaacaaggg taccgcctat accttcttca ccccagggaa 1680
cctaaaacag gccagagagc ttatcaaagt gctggaagag gccaatcagg ctatcaatcc 1740
aaaactgatg cagcttgtgg accacagagg aggcggcgga ggcgggggtg gtcgttctcg 1800
ttaccggacc acttcttcag ccaacaatcc caatctgatg tatcaggatg agtgtgaccg 1860
aaggcttcga ggagtcaagg atggtggccg gagagactct gcaagctatc gggatcgtag 1920
tgaaaccgat agagctggtt atgctaatgg cagtggctat ggaagtccaa attctgcctt 1980
tggagcacaa gcaggccaat acacctatgg tcaaggcacc tatggggcag ctgcttatgg 2040
caccagtagc tatacagctc aagaatatgg tgctggcact tatggagcta gtagcaccac 2100
ctcaactggg agaagttcac agagctctag ccagcagttt agtgggatag gccggtctgg 2160
gcagcagcca cagccactga tgtcacaaca gtttgcacag cctccgggag ctaccaatat 2220
gataggttac atggggcaga ctgcctacca ataccctcct cctcctcccc ctcctcctcc 2280
ttcacgtaaa tgaaaccact caagtggtag tgactccagc agacttaatt acattttaag 2340
gaacactgtc tttccttttt ttttcctctt cgccttttct ttttttttcc ttttttcttt 2400
tttttttttt aatttttccc cccaaccatc gtgatttgtc ttttcatgca gattagttag 2460
aattcactgc caggtttctt ctgcccacca aaatgatcca gtctggaata acattttgta 2520
aaaaaaaaaa aaatatatat atatatatat agctgactgg aagagattaa tttcttcccc 2580
caacttcttg catgttgaag atatttgagc tatttttcat ctaaaagagt aaggtattag 2640
gcccttttgt gggagcccca tgttttgttt ttctgagttg gtggggaggg agggaggggg 2700
agggctgaat tgttttgcag aggaagatgg catctgtgct ttaaatttct cattactggg 2760
ttagaaaaca aagagggatt gccctgcaca ttttcttttg tgcttttaaa tgtttcttaa 2820
gttggaacag gtttcctcgg gcctgttttg actgattgct ggagtgcatt tgatagttaa 2880
aaattactaa ttggttttat ttcccttcac actctgcctc cccacttctc cccccgttac 2940
tgaaaaataa ccattttagt gtcaggctag aaattgaatt gctgagtttt gtgtatcctt 3000
taaattaaaa accacaagtg tttattgtag tggttaaact gtagcatctc agcatctggg 3060
tggaagctgc ctatatttct tcccagttta actggggacc atctgtgaaa ttaattttcc 3120
atccagacag ctgctgtgag caaatgaaca taaatgctcg ctggaaattt actaaccagt 3180
ttttatattg acctgcagtg taaaaagcac atttaattat aaacaatata ttcaaaatgg 3240
gcaaatttta ttttcaaatg cagtgtagag ctagattaaa agcaactctt tgccacctac 3300
tctgcccttt tggcaaagtt accttgaaca aagaatctta agggtttatt aagaactctt 3360
tattttcttc ataccctgtt ctctgcagtg ctttctaaca gcttctgggt gcagattttc 3420
ttcggcatcc ttttgcactc agcttattac aggtaggtag tgcttaagaa aagtcatgga 3480
ggactaaagc ctaagtcctt ttcacttttc ctccatctga aggtaggtga gttcatcctc 3540
ttcatggtaa tgctgtttta ccaagacttt atagcagatg gacccagaaa gaattttctg 3600
ctattgtgtt cactacaaca ggatagggac atcagacagc cccagaaacc ccttccagat 3660
ctgatatggg actattaatt tttatgctgt taattggtat tcattcacaa tgcagttgaa 3720
gggggaaggc tccactgcat tctttggcta aggcctgaat gcttgctcat ctgtaagatc 3780
tatactcgag gttttgtttt ccttttaaaa ttctttaggg agagagggat ggtttctgag 3840
gggttctgaa agtatgattc aatgtgcaac atacaggtag gtcttcagca taagctgaaa 3900
tatatgcatg taaaaacttt gacatctttt tttttaattt tccactttct tcttaacttt 3960
acttctcttt ttgtcccccc cccatcttac agaagttgag gccaagggag aatggtaggc 4020
acagaagaaa catggcaaac tgctctgtgc tttcaaacca aagtgttccc cccaacccca 4080
aatttgtcta agcactggcc agtctgttgt gggcattgtt ttctacaacc aaattctggg 4140
tttttttctt ctttctttaa acatagaggt accaccacaa gggatgccct actctctcgc 4200
agctcttgaa agcatctgtt tgagggaaag gtctctgggc aagcaagtgg ttatttggat 4260
tgcttgcttc cctttttcca cctgggacat tgtaatcata aaataacagt aaattccaaa 4320
cctcaaaaac tattatggcc tgagcacagc tgaaatctag cagagtttaa ctcttctgcc 4380
tccatgtctg tcacttataa ttcaggttct gctgttggct tcagaacatg agcagaagaa 4440
tcgttttatg ctagttattg cattcatggt tgaaactcaa cttagggaaa gggttccaat 4500
gtattaagca atgggctgct tctccccaat cctccctaac aattcgttgt gtggacttct 4560
catctaaaag gttagtggct tttgcttggg atcagtgctc tctattgatg ttcttgctgg 4620
tctccagaca cattcctgtt gcattaagac ttgaaagact tgtagatgtg tgatgttcag 4680
gcacaggatg ctgaaagcta tgttactatt cttagtttgt aaattgtcct tttgatacca 4740
tcatcttgtt ttctttttgt aggtataaat aaaaacactg ttgacaataa aaaaaaaaaa 4800
aaaaa 4805
<210> 26
<211> 3676
<212> DNA
<213> Homo sapiens
<400> 26
gagtagaagt gatttggcct cataacttca cagtggttta ccactttgtt ctatgttctg 60
gttttgtaaa ggatagtact ggaatttgcg tctgaagacc aatattggtg taactcctgt 120
cagtatattg gtaaaatgta gcagaggcag gagtttggat gtttggatgg gattccctta 180
ggattctaca gccaataaag atcctatttc ctatgcatgt cccaggaatc agtaatcctc 240
ttttactctg ttgggatgag tctttttttg tttctgttca gagtggttac taacttcacc 300
ttctttcctc ttgctgtcat ctgcattcgt gcttcccacc tgttgttggc atgtccttta 360
ccttctcttt ccctgccaca tcaacctaca cactgactca tcattgacgt ggaagatgtg 420
gaagatgtca agtttgtgat caactatgac tatccaaaca gctcagagga ttatgtgcac 480
cgtattggcc gaacagcccg tagcaccaac aagggtaccg cctatacctt cttcacccca 540
gggaacctaa aacaggccag agagcttatc aaagtgctgg aagaggccaa tcaggctatc 600
aatccaaaac tgatgcagct tgtggaccac agaggaggcg gcggaggcgg gggtaagggt 660
ggtcgttctc gttaccggac cacttcttca gccaacaatc ccaatctgat gtatcaggat 720
gagtgtgacc gaaggcttcg aggagtcaag gatggtggcc ggagagactc tgcaagctat 780
cgggatcgta gtgaaaccga tagagctggt tatgctaatg gcagtggcta tggaagtcca 840
aattctgcct ttggagcaca agcaggccaa tacacctatg gtcaaggcac ctatggggca 900
gctgcttatg gcaccagtag ctatacagct caagaatatg gtgctggcac ttatggagct 960
agtagcacca cctcaactgg gagaagttca cagagctcta gccagcagtt tagtgggata 1020
ggccggtctg ggcagcagcc acagccactg atgtcacaac agtttgcaca gcctccggga 1080
gctaccaata tgataggtta catggggcag actgcctacc aataccctcc tcctcctccc 1140
cctcctcctc cttcacgtaa atgaaaccac tcaagtggta gtgactccag cagacttaat 1200
tacattttaa ggaacactgt ctttcctttt tttttcctct tcgccttttc tttttttttc 1260
cttttttctt tttttttttt taatttttcc ccccaaccat cgtgatttgt cttttcatgc 1320
agattagtta gaattcactg ccaggtttct tctgcccacc aaaatgatcc agtctggaat 1380
aacattttgt aaaaaaaaaa aaaatatata tatatatata tagctgactg gaagagatta 1440
atttcttccc ccaacttctt gcatgttgaa gatatttgag ctatttttca tctaaaagag 1500
taaggtatta ggcccttttg tgggagcccc atgttttgtt tttctgagtt ggtggggagg 1560
gagggagggg gagggctgaa ttgttttgca gaggaagatg gcatctgtgc tttaaatttc 1620
tcattactgg gttagaaaac aaagagggat tgccctgcac attttctttt gtgcttttaa 1680
atgtttctta agttggaaca ggtttcctcg ggcctgtttt gactgattgc tggagtgcat 1740
ttgatagtta aaaattacta attggtttta tttcccttca cactctgcct ccccacttct 1800
ccccccgtta ctgaaaaata accattttag tgtcaggcta gaaattgaat tgctgagttt 1860
tgtgtatcct ttaaattaaa aaccacaagt gtttattgta gtggttaaac tgtagcatct 1920
cagcatctgg gtggaagctg cctatatttc ttcccagttt aactggggac catctgtgaa 1980
attaattttc catccagaca gctgctgtga gcaaatgaac ataaatgctc gctggaaatt 2040
tactaaccag tttttatatt gacctgcagt gtaaaaagca catttaatta taaacaatat 2100
attcaaaatg ggcaaatttt attttcaaat gcagtgtaga gctagattaa aagcaactct 2160
ttgccaccta ctctgccctt ttggcaaagt taccttgaac aaagaatctt aagggtttat 2220
taagaactct ttattttctt cataccctgt tctctgcagt gctttctaac agcttctggg 2280
tgcagatttt cttcggcatc cttttgcact cagcttatta caggtaggta gtgcttaaga 2340
aaagtcatgg aggactaaag cctaagtcct tttcactttt cctccatctg aaggtaggtg 2400
agttcatcct cttcatggta atgctgtttt accaagactt tatagcagat ggacccagaa 2460
agaattttct gctattgtgt tcactacaac aggataggga catcagacag ccccagaaac 2520
cccttccaga tctgatatgg gactattaat ttttatgctg ttaattggta ttcattcaca 2580
atgcagttga agggggaagg ctccactgca ttctttggct aaggcctgaa tgcttgctca 2640
tctgtaagat ctatactcga ggttttgttt tccttttaaa attctttagg gagagaggga 2700
tggtttctga ggggttctga aagtatgatt caatgtgcaa catacaggta ggtcttcagc 2760
ataagctgaa atatatgcat gtaaaaactt tgacatcttt ttttttaatt ttccactttc 2820
ttcttaactt tacttctctt tttgtccccc ccccatctta cagaagttga ggccaaggga 2880
gaatggtagg cacagaagaa acatggcaaa ctgctctgtg ctttcaaacc aaagtgttcc 2940
ccccaacccc aaatttgtct aagcactggc cagtctgttg tgggcattgt tttctacaac 3000
caaattctgg gtttttttct tctttcttta aacatagagg taccaccaca agggatgccc 3060
tactctctcg cagctcttga aagcatctgt ttgagggaaa ggtctctggg caagcaagtg 3120
gttatttgga ttgcttgctt ccctttttcc acctgggaca ttgtaatcat aaaataacag 3180
taaattccaa acctcaaaaa ctattatggc ctgagcacag ctgaaatcta gcagagttta 3240
actcttctgc ctccatgtct gtcacttata attcaggttc tgctgttggc ttcagaacat 3300
gagcagaaga atcgttttat gctagttatt gcattcatgg ttgaaactca acttagggaa 3360
agggttccaa tgtattaagc aatgggctgc ttctccccaa tcctccctaa caattcgttg 3420
tgtggacttc tcatctaaaa ggttagtggc ttttgcttgg gatcagtgct ctctattgat 3480
gttcttgctg gtctccagac acattcctgt tgcattaaga cttgaaagac ttgtagatgt 3540
gtgatgttca ggcacaggat gctgaaagct atgttactat tcttagtttg taaattgtcc 3600
ttttgatacc atcatcttgt tttctttttg taggtataaa taaaaacact gttgacaata 3660
aaaaaaaaaa aaaaaa 3676
<210> 27
<211> 3071
<212> DNA
<213> Homo sapiens
<400> 27
ccgccatttt gtgagaagca aggtggcctc cacgtttcct gagcgtcttc ttcgcttttg 60
cctcgaccgc cccttgacca cagacatgtc tcgggatcgg ttccggagtc gtggcggtgg 120
cggtggtggc ttccacaggc gtggaggagg cggcggccgc ggcggcctcc acgacttccg 180
ttctccgccg cccggcatgg gcctcaatca gaatcgcggc cccatgggtc ctggcccggg 240
ccagagcggc cctaagcctc cgatcccgcc accgcctcca caccaacagc agcaacagcc 300
accaccgcag cagccaccgc cgcagcagcc gccaccgcat cagccgccgc cgcatccaca 360
gccgcatcag cagcagcagc cgccgccacc gccgcaggac tcttccaagc ccgtcgttgc 420
tcagggaccc ggccccgctc ccggagtagg cagcgcacca ccagcctcca gctcggcccc 480
gcccgccact ccaccaacct cgggggcccc gccagggtcc gggccaggcc cgactccgac 540
cccgccgcct gcagtcacct cggcccctcc cggggcgccg ccacccaccc cgccaagcag 600
cggggtccct accacacctc ctcaggccgg aggcccgccg cctccgcccg cggcagtccc 660
gggcccgggt ccagggccta agcagggccc aggtccgggt ggtcccaaag gcggcaaaat 720
gcctggcggg ccgaagccag gtggcggccc gggcctaagt acgcctggcg gccaccccaa 780
gccgccgcat cgaggcggcg gggagccccg cgggggccgc cagcaccacc cgccctacca 840
ccagcagcat caccaggggc ccccgcccgg cgggcccggc ggccgcagcg aggagaagat 900
ctcggactcg gaggggttta aagccaattt gtctctcttg aggaggcctg gagagaaaac 960
ttacacacag cgatgtcggt tgtttgttgg gaatctacct gctgatatca cggaggatga 1020
attcaaaaga ctatttgcta aatatggaga accaggagaa gtttttatca acaaaggcaa 1080
aggattcgga tttattaagc ttgaatctag agctttggct gaaattgcca aagccgaact 1140
ggatgataca cccatgagag gtagacagct tcgagttcgc tttgccacac atgctgctgc 1200
cctttctgtt cgtaatcttt caccttatgt ttccaatgaa ctgttggaag aagcctttag 1260
ccaatttggt cctattgaaa gggctgttgt aatagtggat gatcgtggaa gatctacagg 1320
gaaaggcatt gttgaatttg cttctaagcc agcagcaaga aaggcatttg aacgatgcag 1380
tgaaggtgtt ttcttactga cgacaactcc tcgtccagtc attgtggaac cacttgaaca 1440
actagatgat gaagatggtc ttcctgaaaa acttgcccag aagaatccaa tgtatcaaaa 1500
ggagagagaa acccctcctc gttttgccca gcatggcacg tttgagtacg aatattctca 1560
gcgatggaag tctttggatg aaatggaaaa acagcaaagg gaacaagttg aaaaaaacat 1620
gaaagatgca aaagacaaat tggaaagtga aatggaagat gcctatcatg aacatcaggc 1680
aaatcttttg cgccaagatc tgatgagacg acaggaagaa ttaagacgca tggaagaact 1740
tcacaatcaa gaaatgcaga aacgtaaaga aatgcaattg aggcaagagg aggaacgacg 1800
tagaagagag gaagagatga tgattcgtca acgtgagatg gaagaacaaa tgaggcgcca 1860
aagagaggaa agttacagcc gaatgggcta catggatcca cgggaaagag acatgcgaat 1920
gggtggcgga ggagcaatga acatgggaga tccctatggt tcaggaggcc agaaatttcc 1980
acctctagga ggtggtggtg gcataggtta tgaagctaat cctggcgttc caccagcaac 2040
catgagtggt tccatgatgg gaagtgacat gcgtactgag cgctttgggc agggaggtgc 2100
ggggcctgtg ggtggacagg gtcctagagg aatggggcct ggaactccag caggatatgg 2160
tagagggaga gaagagtacg aaggcccaaa caaaaaaccc cgattttaga tgtgatattt 2220
aggctttcat tccagtttgt tttgtttttt tgtttagata ccaatctttt aaattcttgc 2280
attttagtaa gaaagctatc tttttatgga tgttagcagt ttattgacct aatatttgta 2340
aatggtctgt ttgggcaggt aaaattatgt aatgcagtgt ttggaacagg agaatttttt 2400
tttccttttt atttctttat tttttctttt ttactgtata atgtccctca agtttatggc 2460
agtgtacctt gtgccactga atttccaaag tgtaccaatt tttttttttt tactgtgctt 2520
caaataaata gaaaaatagt tataatattg gatcttcaac tttgccattc atgcttctat 2580
gcatattagg ctacgtattc cacattgaaa gcatgagagt gtctaggcct ttgaatggca 2640
tatgccattt ctgggaaatg catctggagg ctaagtattg ctttctacaa ataattgccc 2700
cctttgtttt aaaaagaaga aatgcatatt gaagtagttt gatgatttgt ttggcatata 2760
ggaagcacgc tggtgctaag tattttttaa atggttatgt aagcaaagct gaactgtaaa 2820
tcttcaggaa tatgtattaa gattgtggaa tgggtgtaag acaattggta gggggtgaaa 2880
gtgggtttga ttaaatggat cttttatggc cctatgatct atcctttact tgaaagcttt 2940
tgaaaagtgg aaaggtcatt ttgttgcatt tccccatttc ttgtttttaa aagaccaaca 3000
aatctcaagc cctataaatg gcttgtattg aacttttaca tttgaattaa agatgttaaa 3060
catgaaaaaa a 3071
<210> 28
<211> 1329
<212> DNA
<213> Homo sapiens
<400> 28
ggcctgcagt ggacgagcat cgcatagcct gcggggctgg atgctgaccg cccgggccag 60
cacctaggcg gacgcggagc tgtgcagacc agggttcgcg cgggccgggt ggaggctcaa 120
gcggggaccc cggagcgtga gccccggagt cggcggcgct ggggccagag gggccgggag 180
ggagtcggct gaggtggcgg cggaggcgaa gtggcggcgg aggcgaaggg gcggcgggac 240
ccgggcctgg cccgtatgtg tccttggcgg cctagactag gccgtcgctg tatggtgagc 300
cccagggagg cggatctggg cccccagaag gacacccgcc tggatttgcc ccgtaggccc 360
ggcccgggcc cctcgggagc agaacagcct tggtgaggtg gacaggaggg gacctcgcga 420
gcagacgcgc gcgccagcga cagcagcccc gccccggcct ctcgggagcc ggggggcaga 480
ggctgcggag ccccaggagg gtctatcagc cacagtctct gcatgtttcc aagagcaaca 540
ggaaatgaac acattgcagg ggccagtgtc attcaaagat gtggctgtgg atttcaccca 600
ggaggagtgg cggcaactgg accctgatga gaagatagca tacggggatg tgatgttgga 660
gaactacagc catctagttt ctgtggggta tgattatcac caagccaaac atcatcatgg 720
agtggaggtg aaggaagtgg agcagggaga ggagccgtgg ataatggaag gtgaatttcc 780
atgtcaacat agtccagaac ctgctaaggc catcaaacct attgatcgga agtcagtcca 840
tcagatttgc tctgggccag tggtactgag tctaagcact gcagtgaagg agttagtaga 900
aaacagtctg gatgctggtg ccactaatat tgatctaaag cttaaggact atggagtgga 960
tctcattgaa gtttcagaca atggatgtgg ggtagaagaa gaaaactttg aaggcttaac 1020
gatgtcacca tttctacctg ccacgcgtcg gtgaaggttg ggactcgact ggtgtttgat 1080
cacgatggga aaatcatcca ggaaaccccc tacccccacc ccagagggac cacagtcagc 1140
gtgaagcagt tattttctac gctacctgtg cgccataagg aatttcaaag gaatattaag 1200
aagacgtgcc tgcttcccct tcgccttctg ccgtgattgt cagtttcctg aggcctcccc 1260
agccatgctt cctgtacagc ctgcagaact gtgagtcaat taaacctctt ttcttcataa 1320
attaaaaaa 1329
<210> 29
<211> 1334
<212> DNA
<213> Homo sapiens
<400> 29
ggcctgcagt ggacgagcat cgcatagcct gcggggctgg atgctgaccg cccgggccag 60
cacctaggcg gacgcggagc tgtgcagacc agggttcgcg cgggccgggt ggaggctcaa 120
gcggggaccc cggagcgtga gccccggagt cggcggcgct ggggccagag gggccgggag 180
ggagtcggct gaggtggcgg cggaggcgaa gtggcggcgg aggcgaaggg gcggcgggac 240
ccgggcctgg cccgtatgtg tccttggcgg cctagactag gccgtcgctg tatggtgagc 300
cccagggagg cggatctggg cccccagaag gacacccgcc tggatttgcc ccgtaggccc 360
ggcccgggcc cctcgggagc agaacagcct tggtgaggtg gacaggaggg gacctcgcga 420
gcagacgcgc gcgccagcga cagcagcccc gccccggcct ctcgggagcc ggggggcaga 480
ggctgcggag ccccaggagg gtctatcagc cacagtctct gcatgtttcc aagagcaaca 540
ggaaatgaac acattgcagg ggccagtgtc attcaaagat gtggctgtgg atttcaccca 600
ggaggagtgg cggcaactgg accctgatga gaagatagca tacggggatg tgatgttgga 660
gaactacagc catctagttt ctgtggggta tgattatcac caagccaaac atcatcatgg 720
agtggaggtg aaggaagtgg agcagggaga ggagccgtgg ataatggaag gtgaatttcc 780
atgtcaacat agtccagtac agaacctgct aaggccatca aacctattga tcggaagtca 840
gtccatcaga tttgctctgg gccagtggta ctgagtctaa gcactgcagt gaaggagtta 900
gtagaaaaca gtctggatgc tggtgccact aatattgatc taaagcttaa ggactatgga 960
gtggatctca ttgaagtttc agacaatgga tgtggggtag aagaagaaaa ctttgaaggc 1020
ttaacgatgt caccatttct acctgccacg cgtcggtgaa ggttgggact cgactggtgt 1080
ttgatcacga tgggaaaatc atccaggaaa ccccctaccc ccaccccaga gggaccacag 1140
tcagcgtgaa gcagttattt tctacgctac ctgtgcgcca taaggaattt caaaggaata 1200
ttaagaagac gtgcctgctt ccccttcgcc ttctgccgtg attgtcagtt tcctgaggcc 1260
tccccagcca tgcttcctgt acagcctgca gaactgtgag tcaattaaac ctcttttctt 1320
cataaattaa aaaa 1334
<210> 30
<211> 1430
<212> DNA
<213> Homo sapiens
<400> 30
ggggcactga ggagcggcgc ccgcggggca gcgaggagcc cgatgcaggg ttctgcgcgt 60
catttccggt cccgcgggcg ccccgtgaag cccacctgga tccgccagcg ctgtgccact 120
ccccagtgcc gagctccgag ctgtctccgc ggcctcgcgc ccggcccctc caccgcgcac 180
ctcttaggcc ccgcccgcca gcgtcccttt gttgtgaagg cgccggggcc tagcgctatg 240
cctgcggcgg agactgcatc aggctctcgc gtctgcttct acgctttgcc tgggagaggc 300
cctggtggcc tcgttcctgg cgcccggagt ccctgctgcg gccccacccc cgggcggtca 360
cggtgaccca tgctgcccag cctggaggta aaatcgttcg tggctgtggc ttcagcatgt 420
cgtcctcggt gaaaacccca gcactggaag agctggttcc tggctccgaa gagaagccga 480
aaggcaggtc gcctctcagc tggggctctc tgtttggtca ccgaagtgag aagattgttt 540
ttgccaagag cgacggcggc acagatgaga acgtactgac cgtcaccatc acggagacca 600
cggtcatcga gtcagacttg ggtgtgtgga gctcgcgggc gctgctctac ctcacgctgt 660
ggttcttctt cagcttctgc acgctcttcc tcaacaagta catcctgtcc ctgctgggag 720
gcgagcccag catgctaggt gcggtgcaga tgctgtccac cacggttatc gggtgtgtga 780
aaaccctcgt tccttgctgt ttatatcagc acaaggcccg gctttcctac ccacccaact 840
tccttatgac gatgctgttt gtgggtctga tgaggtttgc aactgtggtt ttgggtttgg 900
tcagcctgaa aaatgtggcg gtttcgtttg ctgagacggt gaagagctcc gcccccatct 960
tcacggtgat catgtctcgg atgattctgg gggagtacac aggacgtccc agtgatcggg 1020
aggagcggga agagcttcag ctacaaccag gacgtggtgc tgctgcttct gacagacgga 1080
gtcctgttcc accttcagag cgtcacggcg tacgccctca tggggaaaat ctccccggtg 1140
actttcaggt cccgcaggcc ctgcaccgag tcgccttgtc catggcgctg ccctgcccca 1200
tgcttcctgc gtcctgagta ggaggtatct ccgagacagg aaaagtggcc gctctctctc 1260
actttttctg gaactcatgg tggtctcctg ggcttggtca ctgtctctca ccagcatgtt 1320
tctttgtgcg gtcaggaatt atttccaaat gctcctgaag cctagtgttt tagtgaacat 1380
tagtgattgt tagcagtggt tcaaaaaaaa aaaacttttt tttttttttt 1430
<210> 31
<211> 1082
<212> DNA
<213> Homo sapiens
<400> 31
gactcgactg gtgtttgatc acgatgggaa aatcatccag aaaaccccct acccccaccc 60
cagagggacc acagtcagcg tgaagcagtt attttctaca ctacctgtgc gccataagga 120
atttcaaagg aatgttaaga agacgtgcct gcttcccctt cgccttctgc cgtgattgtc 180
agtttcctga ggcctcccca gccatgcttc ctgtacagcc tgcagaactt acagaacctg 240
ctaaggccat caaacctatt gatcggaagt cagtccatca gatttgctct gggccagtgg 300
tactgagtct aagcactgca gtgaaggagt tagtagaaaa cagtctggat gctggtgcca 360
ctaatattga tctaaagctt aaggactatg gaatggatct cattgaagtt tcaggcaatg 420
gatgtggggt agaagaagaa aacttcgaag gcttaatctc tttcagctct gaaacatcac 480
acatctaaga ttcaagagtt tgccgaccta actcgggttg aaacttttgg ctttcggggg 540
aaagctctga gctcactttg tgcactgagt gatgtcacca tttctacctg ccacgtatcg 600
gcgaaggttg ggactcgact ggtgtttgat cacgatggga aaatcatcca gaaaaccccc 660
tacccccacc ccagagggac cacagtcagc gtgaagcagt tattttctac gctacctgtg 720
cgccataagg aatttcaaag gaatattaag aagaaacgtg cctgcttccc cttcgccttc 780
tgccgtgatt gtcagcttct tgagggctcc ccagccatgc ttcctgtaca gcctgcaaaa 840
ctgatgtaac tggagagcta cgggcatgca gaagttggaa gacgagggaa ggcatcacag 900
aggctgtgag gtgaaccgac ttcaaggaat gggtccttcc cttcagagcc acatgtgtgc 960
gggacaccca gacagaaaac acaaatgcaa agtcaagtgg agggcatttg gaaggagcag 1020
tgaagccaag ccaggaaaca ccaagatggc gagccagtgt ggttgtagag attgtagaga 1080
gg 1082
<210> 32
<211> 1946
<212> DNA
<213> Homo sapiens
<400> 32
agacactgcc cgctctccgg gactccgcgc cgctccccgt tgccttccag gactgagaaa 60
ggggaaaggg aagggtgcca cgtccgagca gccgccttga ctggggaagg gtctgaatcc 120
cacccttggc attgcttggt ggagactgag atacccgtgc tccgctcgcc tccttggttg 180
aagatttctc cttccctcac gtgatttgag ccccgttttt attttctgtg agccacgtcc 240
tcctcgagcg gggtcaatct ggcaaaagga gtgatgcgct tcgcctggac cgtgctcctg 300
ctcgggcctt tgcagctctg cgcgctagtg cactgcgccc ctcccgccgc cggccaacag 360
cagcccccgc gcgagccgcc ggcggctccg ggcgcctggc gccagcagat ccaatgggag 420
aacaacgggc aggtgttcag cttgctgagc ctgggctcac agtaccagcc tcagcgccgc 480
cgggacccgg gcgccgccgt ccctggtgca gccaacgcct ccgcccagca gccccgcact 540
ccgatcctgc tgatccgcga caaccgcacc gccgcggcgc gaacgcggac ggccggctca 600
tctggagtca ccgctggccg ccccaggccc accgcccgtc actggttcca agctggctac 660
tcgacatcta gagcccgcga agctggcgcc tcgcgcgcgg agaaccagac agcgccggga 720
gaagttcctg cgctcagtaa cctgcggccg cccagccgcg tggacggcat ggtgggcgac 780
gacccttaca acccctacaa gtactctgac gacaaccctt attacaacta ctacgatact 840
tatgaaaggc ccagacctgg gggcaggtac cggcccggat acggcactgg ctacttccag 900
tacggtctcc cagacctggt ggccgacccc tactacatcc aggcgtccac gtacgtgcag 960
aagatgtcca tgtacaacct gagatgcgcg gcggaggaaa actgtctggc cagtacagca 1020
tacagggcag atgtcagaga ttatgatcac agggtgctgc tcagatttcc ccaaagagtg 1080
aaaaaccaag ggacatcaga tttcttaccc agccgaccaa gatattcctg ggaatggcac 1140
agttgtcatc aacattacca cagtatggat gagtttagcc actatgacct gcttgatgcc 1200
aacacccaga ggagagtggc tgaaggccac aaagcaagtt tctgtcttga agacacatcc 1260
tgtgactatg gctaccacag gcgatttgca tgtactgcac acacacaggg attgagtcct 1320
ggctgttatg atacctatgg tgcagacata gactgccagt ggattgatat tacagatgta 1380
aaacctggaa actatatcct aaaggtcagt gtaaacccca gctacctggt tcctgaatct 1440
gactatacca acaatgttgt gcgctgtgac attcgctaca caggacatca tgcgtatgcc 1500
tcaggctgca caatttcacc gtattagaag gcaaagcaaa actcccaatg gataaatcag 1560
tgcctggtgt tctgaagtgg gaaaaaatag actaacttca gtaggattta tgtattttga 1620
aaaagagaac agaaaacaac aaaagaattt ttgtttggac tgttttcaat aacaaagcac 1680
ataactggat tttgaacgct taagtcatca ttacttggga aatttttaat gtttattatt 1740
tacatcactt tgtgaattaa cacagtgttt caattctgta attacatatt tgactctttc 1800
aaagaaatcc aaatttctca tgttcctttt gaaattgtag tgcaaaatgg tcagtattat 1860
ctaaatgaat gagccaaaat gactttgaac tgaaactttt ctaaagtgct ggaactttag 1920
tgaaacataa taataatggg tttata 1946
<210> 33
<211> 1819
<212> DNA
<213> Homo sapiens
<400> 33
tattcaataa ggactgttat ttctagtata gagaggaggg ctcctaggcc tggctaagca 60
gtttaagata aaatgcaaaa tgacccaatt caggatgatt atagttggtt taaatttggt 120
tgctgaggca caaacaaaag tgttggattc tgtagttttt gttgtgatta cagaacacat 180
gcagtatctt ccagaaccct ttgataaagc tgaagtaagg atgggctcac atggcccatg 240
tgagtaagaa gctgtgttga cagagtggac gataccttca attatggctt aacaaaaaat 300
gcctgaaaat ggaataactt agaaggaact cttcctttaa aggatttaat ggcaggtgca 360
gtggcttacg cctgtaatcc cagcactttg ggagcctgag gcagaagatg gcttgagccc 420
aggagtttga ggcagcggtg agccataatc ataccactgc acttaagcct gggcaacaca 480
atgagaccct gtctcctgtc tttaaaaaaa agagacagag acctacctgt atgctaggag 540
catccttctc actgtaggtc ggatgtggtg gttctgtttt aaatttgctg aattgtgact 600
ttttttcttt ttcttttttt tttttttttt tttgtttttt tttgaggcag ggtctcactc 660
tgtcgcccag gctggagtgc agtggtgtga tctcggctca cttcaacctc cacctcctgg 720
gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc gtgcaccacc 780
atgcctggct aatttttgta tttttagtag agatggggtt tcacaatgtt gcccaggttg 840
gtctcgaacc gctgacctta agcgatccgc ctgccttggc ctccccaagg tgctggaatt 900
acaggcatga gccaccgcgc ccggctgact tttttttttt ctttctttct ttttgagaca 960
gagttttgct cagtctccca ggctggagtg caatggcaac aacatggctc gctgcagcct 1020
caatctgctg tgctcaggta ttcctcctgc ctcagcctcc tgagtagctg ggactacagg 1080
cgcatgccac cacacctggc tattgtggat tttaagaaat tttttttgta gagacagggt 1140
cttactatgt tgcccaggtt gttcttgaac tcttgggctc cagagagcct cccatctcag 1200
cctcccaaag tgctgagatt ataggcgtga gccaccacac ttagcctatt gtgacttttt 1260
agagtctcta atactttctt ttagggcact aaaaacttaa tcttagatcc agttggtatt 1320
catttgggtg aatgaagtgg tagggaccta ccttaatttt ttttccaggt ttttgtgatt 1380
gaataagttc cagatactca aagcgaccta gatcagtgat gaaatttttg actgcatttg 1440
gacctatttc tgggatctcc ttttactgat ttctctgtat attcatgagc aaccttaaat 1500
tattttagac tatttaatta ttatgttcta ttttctggaa agttttgtcc ttcactcttc 1560
tttttcaaaa ttttcctgat tgttatttca taaatatttt ttcacagaat caactggttt 1620
tgaacctcaa tttacttata ggttaattta gagagaattg acttttaaaa ttatattaaa 1680
ggccaggcat ggtagctcat gcttataatc ctggcatttt ggggggctga ggcagatgga 1740
tcacatgatc ccaggatttg agactggcct gggcaacata gtgagatctc atctcttaaa 1800
aaaaaaaaaa aaaaaaaaa 1819
<210> 34
<211> 3609
<212> DNA
<213> Homo sapiens
<400> 34
gagccgcggc cgcgcggagg aagcgaagga ggcgggagcg gagacctcgc tgcgctcatg 60
gcgtcgcccg ggcattcaga tttgggagaa gtagccccag aaataaaagc atcagagaga 120
cgaacagctg tggccattgc agatttggaa tggagagaaa tggaaggaga tgattgcgag 180
ttccgttatg gagatggtac aaatgaggct caggacaatg attttccaac agtggagaga 240
agcaggcttc aagaaatgct gtcacttttg ggcctagaga cgtaccaggt ccagaaactc 300
agcctccagg actctctgca gatcagtttt gacagtatga agaactgggc ccctcaggtt 360
cccaaagact tgccctggaa tttcctcagg aagttgcagg ccctcaatgc tgatgccagg 420
aataccacta tggtgctgga cgtgctccca gacgccaggc ctgtggagaa ggagagccag 480
atggaagagg agatcatcta ctgggaccca gctgatgacc ttgctgccga catttattcc 540
ttttctgagc tgcccacccc tgatacgcca gtgaacccct tagaccttct ctgtgccctg 600
ctgctctcct cagacagttt cctgcaacaa gaaatagcgt tgaaaatggc cctctgccag 660
tttgcactcc cactcgtgtt gcctgactcg gagaaccact accatacatt tctgctgtgg 720
gccatgcggg gcattgtgag gacatggtgg tcccagcccc caaggggcat ggggagcttc 780
cgggaagaca gcgtggtctt gtccagggcg cccgccttcg ccttcgtgcg catggacgtc 840
agtagcaact ccaagtccca gcttctcaac gccgtcctca gcccgggcca caggcagtgg 900
gactgcttct ggcatcggga cctcaacttg ggcaccaatg cccgggagat ttcggatggg 960
ttggtagaaa tttcctggtt ttttcccagc ggaagggagg acttggacat tttcccagaa 1020
cctgtggcct ttctgaacct gagaggtgac atcgggtctc actggctgca gtttaagctc 1080
ttgacagaaa tctcctccgc tgtgtttata ttgactgaca atatcagtaa gaaggaatac 1140
aaattgctgt actccatgaa ggagtcaacc acaaaatact acttcatcct gagtccctac 1200
cgtgggaagc gcaacacaaa cctgagattt ctgaataagt taattcctgt gctgaaaata 1260
gaccactcac atgtcctggt aaaggtcagc agcactgaca gcgacagctt cgtgaagagg 1320
atccgggcca tcgttgggaa tgtgctgcgg gcaccctgca ggcgggtatc tgtggaggac 1380
atggcgcacg cagcccgcaa actgggccta aaggtcgacg aggactgtga ggagtgtcag 1440
aaagcgaaag accggatgga gaggattacc aggaaaatca aagactcgga tgcctacaga 1500
agggacgagc tgaggctgca gggggacccc tggagaaagg cagcccaagt ggagaaggag 1560
ttctgccagc tccagtgggc cgtggacccc cctgagaagc acagggctga gctgaggcgg 1620
cggctgctag aacttcgaat gcagcagaac ggccatgatc cctcctcggg ggtgcaggag 1680
ttcatctcgg ggatcagcag cccctccttg agtgagaagc agtacttcct gaggtggatg 1740
gagtggggcc tggcacgggt ggcccagccg cgactgagac agcctccgga gacgcttctc 1800
accctgagac caaagcatgg gggcaccaca gacgtggggg agccgctctg gcctgagccc 1860
ctaggggtgg aacacttctt gcgggagatg ggacagtttt atgaggctga gagctgtctt 1920
gtggaggcag ggaggctgcc ggcaggccag aggcgttttg cccacttccc aggcttggcc 1980
tcggagctgc tgctgacagg gctgcctctg gagctaatcg atgggagcac gctgagcatg 2040
cccgtccgct gggtcacagg gctcctgaag gagctgcacg tccgactgga gagacggtca 2100
aggctggtgg ttctgtcaac cgtcggggtg ccaggcacgg gcaagtccac actcctcaac 2160
accatgtttg ggctgcggtt tgccacaggg aagagctgcg gtcctcgagg ggccttcatg 2220
cagctcatca cagtggctga gggcttcagc caggacctgg gctgtgacca catcctggtg 2280
atagactccg ggggcttgat aggtggggcc ttgacgtcag ctggggacag atttgagctg 2340
gaggcttcct tggccactct gctcatggga ctgagcaatg tcaccgtgat cagtctagct 2400
gaaaccaagg acattccagc agctattctg catgcatttc tgaggttaga aaaaacgggg 2460
cacatgccca actaccagtt tgtataccag aaccttcatg atgtatctgt tcccggccct 2520
aggcccagag acaagagaca gctcctggat ccacctggtg acctgagcag ggctgcagcc 2580
cagatggaga aacagggcga cggcttccgg gcactggcag gcctggcctt ctgcgaccct 2640
gagaagcagc acatctggca catcccaggc ctgtggcacg gagcacctcc catggccgca 2700
gtgagcttgg cctacagtga agccatattt gaattgaaga gatgcctact cgaaaacatc 2760
aggaacggct tgtcgaacca aaacaaaaac atccagcagc tcattgagct ggtgagacgg 2820
ctgtgagtgt gcagagaaac ccagttcagg tgtaggaggc tgctgtgggc agccctgtct 2880
gatggggcac ccgtgtgggg ctgtgctctg gtgcctgaga atggctggtg cccaatcgac 2940
atgagaagac gaggaaaaga cagggtttgg agtctcctca acagtgttaa aagaggaagt 3000
gacctcacag accagctcag agatgttacc aagaatatca cagcccccag ggtagggaga 3060
caagcagcag tttgttctgt ctcagctcct gtcaaggatc ctgcggggtg ggccctctgt 3120
atagctgctc tctgtcactg gcccctggag tgggagcagc gtccttagtc actgcaggcc 3180
caggcgggca ggtggtccca ggacagaggt ggggaagttg tcctgaggaa gcagaagtag 3240
gccttgctcc cgcccaaccc aagggcctcc agtggaccag cattcaagat gtgagtgccc 3300
gtggtgtgca aggcactccc atggcaccgt atttattgac tgatctgtga aggcttccct 3360
gacccctgcc caggaagagt tcactggtcg ctctgttgtg ccccacagca ctttgttata 3420
cctctgccac acacttcacg cagcgcgttg taactcatgt gtttacatgt ctgtcccccc 3480
agactgtgag ctccttgagg gcagggactg tacattctcc agctctgtgt ccccagggcc 3540
tggcacattg tagacgctta ataaatgtct gttaaatgaa tgagtgcaca aaaaaaaaaa 3600
aaaaaaaaa 3609
<210> 35
<211> 4976
<212> DNA
<213> Homo sapiens
<400> 35
gggcgggcgg gccgcaggct gtcgggctgg ggctgaggct gaggctgagg ttgaggcggc 60
ggcggcggcg gccgggtgcc cgggacagcg acgcagcgcg ccggcggccg cgacagggcc 120
agcgagagcc ccgcagcccg ccgcagctgc cgcctcgccg cggccgggcc ggagagcacg 180
gcggcgggag cgcggcctta ggaggcggcc ggagcggtgg gcacagctcg gcgcggagcg 240
tcctgtcagg cggcggccga gggcgtcgcg gactctcccc gcgatgatgc cgatgatatt 300
aactgttttc ttgagcaaca atgaacagat tttaacagaa gttcctataa caccggaaac 360
aacctgtcga gatgttgtag aattttgcaa ggaacctgga gaaggcagct gccatttagc 420
tgaagtgtgg aggggaaatg aacgtcccat accctttgat catatgatgt acgaacatct 480
tcagaaatgg ggtccacgga gggaagaagt gaaatttttc cttcgacacg aggactcccc 540
aactgagaac agtgaacaag gtggccgtca gacccaagag caacgaactc agagaaatgt 600
aataaatgta cctggagaaa aacgtactga aaatggggtt gggaatccac gtgttgaact 660
taccctctca gagctccaag atatggcagc taggcaacag cagcagattg aaaatcagca 720
gcagatgttg gttgccaagg aacagcgttt acattttcta aagcaacagg agcgccgtca 780
gcagcagtct atttctgaaa atgaaaagct tcagaaattg aaagaacgag ttgaagccca 840
ggagaacaag ctgaagaaaa ttcgtgcaat gagaggacaa gtcgactaca gcaaaatcat 900
gaacggcaat ctgtctgctg aaatagaaag gttcagtgcc atgttccagg aaaagaagca 960
ggaagtacag actgcaattt taagggttga tcagcttagt cagcaattgg aagatttaaa 1020
gaaaggaaaa ctgaatgggt tccagtctta caatggcaaa ttgacgggac cagcggcggt 1080
ggagttaaaa agactgtacc aagaactaca gattcgtaac caacttaacc aggaacaaaa 1140
ttcaaaactt cagcagcaga aggaactctt aaataagcgc aacatggagg tggccatgat 1200
ggacaagcga atcagtgaac tgcgtgaacg tctctatggg aaaaaaattc agctgaaccg 1260
tgtgaatggc acgtcatcac cacagtcccc tctgagcaca tcgggcaggg tcgctgctgt 1320
ggggccttat atccaggttc ccagtgccgg aagctttcct gtgctggggg accctataaa 1380
gccccagtct ctcagtattg cctcaaatgc tgctcatgga agatccaaat ccgctaatga 1440
tggaaactgg ccaacattaa aacagaattc tagctcttcc gtgaaaccag tgcaggtggc 1500
cggtgcagac tggaaggatc cgagcgtgga ggggtctgtc aagcagggca ctgtctccag 1560
ccagcctgtg cccttctcag cactgggacc cacggagaag ccgggcatcg agattggtaa 1620
agtgccacct cccatcccgg gtgtaggcaa gcagctgcct ccaagctatg ggacataccc 1680
aagtcctaca cctctgggtc ctgggtcgac aagctccctg gaaaggagga aggaaggcag 1740
cttgcccagg cccagtgcag gcctgccaag tcgacagagg cccaccctgc tgcccgccac 1800
aggcagcacc ccccagccag gctcctcaca acagattcag cagaggattt ccgtaccgcc 1860
aagtcccacg tacccgccag cgggaccacc tgcatttcca gctggggaca gcaagcctga 1920
actcccactg acagtggcca ttaggccttt cctggctgat aaagggtcaa ggccacagtc 1980
tcccaggaaa ggaccccaga cagtgaattc aagttccata tactccatgt acctccagca 2040
agccacacca cctaagaatt accagccggc agcacacagc gccttaaata agtcagttaa 2100
agcagtgtat ggtaagcccg ttttaccttc gggttcaacc tctccatcgc cgctgccgtt 2160
tcttcacggg tcactgtcca cgggcacacc acagcctcag ccaccttcag aaagtactga 2220
gaaagagcct gagcaggatg gccccgccgc ccccgcagat ggcagcaccg tggagagcct 2280
gccacggcca ctcagcccca ccaagctcac gcccatcgtg cattcgccac tgcgctacca 2340
gagtgatgca gacctggagg ccctccgcag gaagctggcc aacgcgcccc ggcccctgaa 2400
aaagcgcagc tccatcacag agcccgaggg ccccggcggg cccaacatcc agaagctgct 2460
gtaccagcgc ttcaacaccc tggccggtgg catggagggc acccctttct accagcccag 2520
cccctcccag gacttcatgg gcaccttggc cgatgtggac aatggaaaca ccaatgccaa 2580
tggaaacctg gaagagctcc cccctgccca gcccacagcc ccactccccg ctgagcctgc 2640
cccgtcatca gatgccaatg ataatgagtt accttccccc gaaccagagg agctcatctg 2700
tccccaaacc acccaccaaa ctgccgagcc ggcagaggac aataacaaca acgtggccac 2760
ggtccccacc acggagcaga tcccgagtcc tgtggctgag gccccatctc caggggaaga 2820
gcaggtccct ccagcacctc ttccccctgc cagccaccct cctgccacct ccacgaacaa 2880
gcggaccaac ttgaagaagc ccaactcgga gcggacgggg cacgggctga gagtccggtt 2940
taaccccctg gcactgctcc tagacgcgtc tctggaagga gagttcgatc tggtgcagag 3000
gatcatctat gaggtggaag atcccagcaa gcccaacgac gaagggatca ccccactgca 3060
caacgccgtc tgcgccggcc accatcacat cgtgaagttc ctgctggatt ttggtgtcaa 3120
cgtgaatgct gctgatagtg atggatggac gccgctgcac tgcgctgcct cttgtaacag 3180
cgttcacctc tgcaaacagc tggtggagag tggtgccgcc atttttgcct caaccataag 3240
cgacattgaa actgctgcag acaagtgtga ggagatggag gaaggctaca tccagtgctc 3300
ccagtttcta tatggggtgc aggaaaagct gggtgtgatg aacaaaggtg tggcgtatgc 3360
tctgtgggac tacgaggccc agaacagtga cgagctgtcc ttccacgaag gggacgccct 3420
caccatcctg aggcgcaagg acgaaagcga gactgagtgg tggtgggctc gccttggaga 3480
ccgggagggc tatgtgccca aaaacctgct ggggctgtat ccacggatca aaccccgaca 3540
gcgaacactc gcctgaactt ccttttggag caccgcatgg tcttgccagc taccaggagc 3600
cacttaagag attattgtgc tgttttccag gaaagctgca gctagaaaat ggtcttaatg 3660
gtgctcactt tagcagacag cgtccacaat gtgaatccta cagtttccag gtgaggccct 3720
ttctccagtt tgcccattaa ctgggagagg tactttcgcc tccaaggact gaattttgcc 3780
aattactata aatccaaata aatacccact ttcaaaacac ccacccctct tgccattaag 3840
aagtcccata acccccggtt ggttgccagt gaagacagaa gctcttactg acttggcccc 3900
gaggccatca ccccctccag cagtgaacac tgtccgccgc tgtgaggcct gctcccctgc 3960
gaccgccctg ccccccgtca ccgaatcgga cactcatcct ttctcacact tcccacacat 4020
gatccttctt cccttcatca ccaaaggagc ctctgtatgg aaacatgtcc agtgttgctg 4080
cccagtgtgt atgcctccca gtacccactc tgctcggccg ccttgggggt tccgcttcct 4140
gttccagttc acctaaaggc tgattgtgca ggcccagcac tgtggctgga ctgccgcgcc 4200
acgggcacca ggacccctaa gaccaagtga caactgggag agcctcagca tatactcttc 4260
tcctccgatc tcacagcctg tcatgctgct cagtgtggtt ctcacccctg caagctcaaa 4320
ttcagttccc tgaatggagt caggtgctgg aggccgtggc agcggagggt ggttggggtt 4380
ggggctgggg gtggactggt gtgagggcag accagggcca ggtagacggg gctgtttggt 4440
gcctgaagga tggcagacgc ctggtgtcag gaggggccgc caccaaggag cagcagctgg 4500
ggcagaggag ctggggtcag gggccacccc tctctgccga tctccctgcc tgggctggct 4560
gtgaggccac ctttgtccca ggcccagcct caaggcaagg agggcgcttc actgaggtgt 4620
gaattgtacg tacaggcttt ttatatacca aaagtatttt ttgactagac cattcaaagc 4680
tacccgaact atgttggaaa tttttttttt ctcattaaaa tacaggccct taggctctat 4740
ttttcatgta tgagtcgtgt gtaatttatg taaaaatgtg tgtacagact cactgatgca 4800
gcactgtagc ccatcacctt ggagcactga ctgtacatag tgtggtgaag aaaagtgaac 4860
gcccttgtag agcagcccga ccacaggagc atggccgctg ccagcccaga cgctgctgac 4920
gctgtgtaaa tgtgcacaat aaacccgtct caccccggca aaaaaaaaaa aaaaaa 4976
<210> 36
<211> 6659
<212> DNA
<213> Homo sapiens
<400> 36
cgcgcgggcg cgggggacgg cgcaggggcc gcctggctgg agcagccaga ggggatagct 60
tcgtcgagaa cggaggacac cggcggtcca gggtcctggg cagtcgcgcc agagctgagc 120
ggagggcgcg gcgcgagaac gaatctttgt gacattctct ctcagcattc tttatcccct 180
gtttgctgaa gacttcgaca aaagctggtc ttagctgttg gcattctcct gagaaaagga 240
tagcttcaga aatcagaaaa acatttggga ggtgtctagc ccagtggacc ttctgaagag 300
caatgctaag aagacgtttg gtttaaagaa ttaaaaggaa gaacaactta agagcttctt 360
caaagtttcc cgcatgaaaa ttacttaaac gttgcacaca acgtttcaca aaatcttttg 420
tgaaagaaga aaaggaaatt cagtgtgtga gtctcagcag gagttaagct aatgcagctt 480
aaaataatgc cgaaaaagaa gcgcttatct gcgggcagag tgcccctgat tctcttcctg 540
tgccagatga ttagtgcact ggaagtacct cttgatccaa aacttcttga agacttggta 600
cagcctccaa ccatcaccca acagtctcca aaagattaca ttattgaccc tcgggagaat 660
attgtaatcc agtgtgaagc caaagggaaa ccgcccccaa gcttttcctg gacccgtaat 720
gggactcatt ttgacatcga taaagaccct ctggtcacca tgaagcctgg cacaggaacg 780
ctcataatta acatcatgag cgaagggaaa gctgagacct atgaaggagt ctatcagtgt 840
acagcaagga acgaacgcgg agctgcagtt tctaataaca ttgttgtccg cccatccaga 900
tcaccattgt ggaccaaaga aaaacttgaa ccaatcacac ttcaaagtgg tcagtcttta 960
gtacttccct gcagaccccc aattggatta ccaccaccta taatattttg gatggataat 1020
tcctttcaaa gacttccaca aagtgagaga gtttctcaag gtttgaatgg ggacctttat 1080
ttttccaatg tcctcccaga ggacacccgc gaagactata tctgttatgc tagatttaat 1140
catactcaaa ccatacagca gaagcaacct atttctgtga aggtgatttc agtggatgaa 1200
ttgaatgaca ctatagctgc taatttgagt gacactgagt tttatggtgc taaatcaagt 1260
agagagaggc caccaacatt tttaactcca gaaggcaatg caagtaacaa agaggaatta 1320
agaggaaatg tgctttcact ggagtgcatt gcagaaggac tgcctacccc aattatttac 1380
tgggcaaagg aagatggaat gctacccaaa aacaggacag tttataagaa ctttgagaaa 1440
accttgcaga tcattcatgt ttcagaagca gactctggaa attaccaatg tatagcaaaa 1500
aacgcattag gagccatcca ccataccatt tctgttagag ttaaagcggc tccatactgg 1560
atcacagccc ctcaaaatct tgtgctgtcc ccaggagagg atgggacctt gatctgcaga 1620
gctaatggca accccaaacc cagaattagc tggttaacaa atggagtccc aatagaaatt 1680
gcccctgatg accccagcag aaaaatagat ggcgatacca ttattttttc aaatgttcaa 1740
gaaagatcaa gtgcagtcta tcagtgcaat gcctctaatg aatatggata tttactggca 1800
aacgcatttg taaatgtgct ggctgagcca ccacgaatcc tcacacctgc aaacacactc 1860
taccaggtca ttgcaaacag gcctgcttta ctagactgtg ccttctttgg gtctcctctc 1920
ccaaccatcg agtggtttaa aggagctaaa ggaagtgctc ttcatgaaga tatttatgtt 1980
ttacatgaaa atggaacttt ggaaattcct gtggcccaaa aggacagtac aggaacttat 2040
acgtgtgttg caaggaataa attagggatg gcgaagaatg aagttcactt agaaatcaaa 2100
gatcctacat ggatcgttaa acagcccgaa tatgcagttg tgcaaagagg gagcatggtg 2160
tcctttgaat gcaaagtgaa acatgatcac accttatccc tcactgtcct gtggctgaag 2220
gacaacaggg aactgcccag tgatgaaagg ttcactgttg acaaggatca tctagtggta 2280
gctgatgtca gtgacgatga cagcgggacc tacacgtgtg tggccaacac cactctggac 2340
agcgtctccg ccagcgctgt gcttagcgtt gttgctccta ctccaactcc agctcccgtt 2400
tacgatgtcc caaatcctcc ctttgactta gaactgacag atcaacttga caaaagtgtt 2460
cagctgtcat ggaccccagg cgatgacaac aatagcccca ttacaaaatt catcatcgaa 2520
tatgaagatg caatgcacaa gccagggctg tggcaccacc aaactgaagt ttctggaaca 2580
cagaccacag cccagctgaa gctgtctcct tacgtgaact actccttccg cgtgatggca 2640
gtgaacagca ttgggaagag cttgcccagc gaggcgtctg agcagtattt gacgaaagcc 2700
tcagaaccag ataaaaaccc cacagctgtg gaaggactgg gatcagagcc tgataatttg 2760
gtgattacgt ggaagccctt gaatggtttc gaatctaatg ggccaggcct tcagtacaaa 2820
gttagctggc gccagaaaga tggtgatgat gaatggacat ctgtggttgt ggcaaatgta 2880
tccaaatata ttgtctcagg cacgccaacc tttgttccat acctgatcaa agttcaggcc 2940
ctgaatgaca tggggtttgc ccccgagcca gctgtagtca tgggacattc tggagaagac 3000
ctcccaatgg tggctcctgg gaacgtgcgt gtgaatgtgg tgaacagtac cttagccgag 3060
gtgcactggg acccagtacc tctgaaaagc atccgaggac acctacaagg ctatcggatt 3120
tactattgga agacccagag ttcatctaaa agaaacagac gtcacattga gaaaaagatc 3180
ctcaccttcc aaggcagcaa gactcatggc atgttgccgg ggctagagcc ctttagccac 3240
tacacactga atgtccgagt ggtcaatggg aaaggggagg gcccagccag ccctgacaga 3300
gtctttaata ctccagaagg agtccccagt gctccctcgt ctttgaagat tgtgaatcca 3360
acactggact ctctcacttt ggaatgggat ccaccgagcc acccgaatgg cattttgaca 3420
gagtacacct taaagtatca gccaattaac agcacacatg aattaggccc tctggtagat 3480
ttgaaaattc ctgccaacaa gacacggtgg actttaaaaa atttaaattt cagcactcga 3540
tataagtttt atttctatgc acaaacatca gcaggatcag gaagtcaaat tacagaggaa 3600
gcagtaacaa ctgtggatga agctggtatt cttccacctg atgtaggtgc aggcaaagtt 3660
caagcagtaa atcccaggat cagcaatctt actgctgcag ctgctgagac ctatgccaat 3720
atcagttggg aatatgaggg accagagcat gtgaactttt atgttgaata tggtgtagca 3780
ggcagcaaag aagaatggag aaaagaaatt gtaaatggtt ctcggagctt ctttgggtta 3840
aagggtctaa tgccaggaac agcatacaaa gttcgagttg gtgctgtggg ggactctggt 3900
tttgtgagtt cagaggatgt gtttgagaca ggcccagcga tggcaagccg gcaggtggat 3960
attgcaactc agggctggtt cattggtctg atgtgtgctg ttgctctcct tatcttaatt 4020
ttgctgattg tttgcttcat cagaagaaac aagggtggta aatatccagt taaagaaaag 4080
gaagatgccc atgctgaccc tgaaatccag cctatgaagg aagatgatgg gacatttgga 4140
gaatacagtg atgcagaaga ccacaagcct ttgaaaaaag gaagtcgaac tccttcagac 4200
aggactgtga aaaaagaaga tagtgacgac agcctagttg actatggaga aggggttaat 4260
ggccagttca atgaggatgg ctcctttatt ggacaataca gtggtaagaa agagaaagag 4320
ccggctgaag gaaacgaaag ctcagaggca ccttctcctg tcaacgccat gaattccttt 4380
gtttaatttt taagctcttt gccaatattc catttctcta gaatgtttat cctaagcact 4440
tgtttgtcag ccctctcata ctatgaacat atgggtagag agtatatttt ctgctgtatg 4500
ttagtattat gagaatagtt acagcaaaaa cataactcag tcaaatgata tgttaatatg 4560
aactggaatg caaagtgcat actttttcat tcaaaatggg tattcttgat ttcctcagaa 4620
ctgataaaaa ataatgcaac atcaccaaca gatcctgtta tttcctctgc aggatacagt 4680
tcaatatgat gcatgaaaaa tgctccacat ttaaaggaca tacccgtgta tgttatgaaa 4740
acatggtttg atactttgtt tatactaccc tcagctgaac ccctatatat gaattccgtt 4800
ttcattgtca agaatgttac tgtagtattc tctagaactt caatgtcttt gtggacattg 4860
ttgtgaaatt ggtgactatg tatagctgtc gttagtcttt ttgggagact gttaggaaca 4920
gtttgtacag tatatacttg ctaaatgagt tcattatgac agtcacattg ctgatgctta 4980
ctgagaacta ttacctactc ttggctcctg ttactccgta ggcttcttaa tcttccaggc 5040
attacagcag cacagtgttc tactttttac atcatttcta tgttcggttg tttttaggca 5100
taaacaatgt gtattgcagt gcatttcggc atttgtgcca tactgaaaga atcaaaaaca 5160
aatcatccaa attaaatttc aaacattatt tcagagaaca cagggcaaga cacatacagt 5220
gccttcagat attaagcatt ccacaacatc gtgcattctg tatcagctgg tccagtccat 5280
tctgggtcct agattactgt cattgtctaa aagtaacttt taaaaagcag agttcatgaa 5340
aactgcaatg ctgggaaaag aaggaaacat gaaaataaaa ataagacagt ttattagaaa 5400
tagcatttcc tcataagcat aaaaagaaaa tctttgttgc caactgaagc acatgatgat 5460
tttgtggtcc tttatggttt ctattacatt cagtaagaaa gatgtcaaca tgctagaaaa 5520
ttaattttaa aactaagtta ttccaacact aaaagcatac aacagcatgc caacagtaat 5580
atattattct ccaagacttt acctatgtaa gtgttcaaaa ctctgcagca ttaaacaacg 5640
tgtatgcaaa ttgttatgga tacatttcag aatctaagaa atcaggcaag tgcttaaaag 5700
gccaacggtc caagggatta catctgcagt ttaaaaagta aatatatatt ctatcgtatt 5760
cataaacaat atctatcaaa tgggttacct ccaaatatga aaatctataa caacctatgg 5820
ttgaaggaat gctcagtttc atttgccaat aaattggttt ctcataactt gcatcaagtt 5880
taattttaag taaagctttt tatatgtaga tattttgttg aatttgtaaa tacacttaaa 5940
atgtagatgc tatatgctta taggtgttac atacaaataa acatgcaatg tttatgttgt 6000
actgtataag aggtaagcta attaatgcag tgaatgggat tggaaagcat ctacttaaat 6060
atctattggg ttcccccctc cccccacctt ttttgctgtg aaactgaaat agtgaacttt 6120
tctacgtatt gacagcagat ttttcgatga aatcttcaga gctttgccta tggggcacag 6180
taggcctagt aacctggcat gtttgatata tgtaggtaaa gcataattta aagtaatccc 6240
aggtaaagat ggccctaaat actttcatgt ctctatattc atttttcaca gatccacctg 6300
tctcttgaaa atataaaaag acaaaacagg tttgccttgg catcagagag cacaaagatt 6360
aaaagttact ttaaatttgc caatattttg ggagaacaat aaaactacat tttttcctct 6420
tccatactgg tagatgcgaa atttatctgt gcatgaaagg gtcacttctg taatagtgca 6480
acagatttgg tattaaaaat taaatgtggt tttaaaagtt cctctctctt ttgtaattta 6540
tgttcccaat tgagtgtgaa tgtccaagta atggtgtatg taatggtaca ggcaaatgtg 6600
actggatttc cctcaaaaaa gtaactatta aacagtcttg atctctttgt gacttttaa 6659
<210> 37
<211> 2821
<212> DNA
<213> Homo sapiens
<400> 37
gaaaccgttt ctacatggct ggctctaagc cagatgatat ttcatagtgc aaagagggat 60
agaacctcac tggtggccaa atgtgattat atgctataac cctgtgcccc tactctgaca 120
cccaccccca agcagttacc ctctgttgga agcctgcagc tttctttgtt tgtttcttta 180
attatacaga cagtaggatc tgcatcctta ctagcatata gaaaaatcag agaaacaatg 240
caaccaagag tgctgttttc atttgtttct tctgcatcct tttaatggaa ttttgtaggt 300
ctcttgaaag tgatgcagaa gaccacaagc ctttgaaaaa aggaagtcga actccttcag 360
acaggactgt gaaaaaagaa gatagtgacg acagcctagt tgactatgga gaaggggtta 420
atggccagtt caatgaggat ggctccttta ttggacaata cagtggtaag aaagagaaag 480
agccggctga aggaaacgaa agctcagagg caccttctcc tgtcaacgcc atgaattcct 540
ttgtttaatt tttaagctct ttgccaatat tccatttctc tagaatgttt atcctaagca 600
cttgtttgtc agccctctca tactatgaac atatgggtag agagtatatt ttctgctgta 660
tgttagtatt atgagaatag ttacagcaaa aacataactc agtcaaatga tatgttaata 720
tgaactggaa tgcaaagtgc atactttttc attcaaaatg ggtattcttg atttcctcag 780
aactgataaa aaataatgca acatcaccaa cagatcctgt tatttcctct gcaggataca 840
gttcaatatg atgcatgaaa aatgctccac atttaaagga catacccgtg tatgttatga 900
aaacatggtt tgatactttg tttatactac cctcagctga acccctatat atgaattccg 960
ttttcattgt caagaatgtt actgtagtat tctctagaac ttcaatgtct ttgtggacat 1020
tgttgtgaaa ttggtgacta tgtatagctg tcgttagtct ttttgggaga ctgttaggaa 1080
cagtttgtac agtatatact tgctaaatga gttcattatg acagtcacat tgctgatgct 1140
tactgagaac tattacctac tcttggctcc tgttactccg taggcttctt aatcttccag 1200
gcattacagc agcacagtgt tctacttttt acatcatttc tatgttcggt tgtttttagg 1260
cataaacaat gtgtattgca gtgcatttcg gcatttgtgc catactgaaa gaatcaaaaa 1320
caaatcatcc aaattaaatt tcaaacatta tttcagagaa cacagggcaa gacacataca 1380
gtgccttcag atattaagca ttccacaaca tcgtgcattc tgtatcagct ggtccagtcc 1440
attctgggtc ctagattact gtcattgtct aaaagtaact tttaaaaagc agagttcatg 1500
aaaactgcaa tgctgggaaa agaaggaaac atgaaaataa aaataagaca gtttattaga 1560
aatagcattt cctcataagc ataaaaagaa aatctttgtt gccaactgaa gcacatgatg 1620
attttgtggt cctttatggt ttctattaca ttcagtaaga aagatgtcaa catgctagaa 1680
aattaatttt aaaactaagt tattccaaca ctaaaagcat acaacagcat gccaacagta 1740
atatattatt ctccaagact ttacctatgt aagtgttcaa aactctgcag cattaaacaa 1800
cgtgtatgca aattgttatg gatacatttc agaatctaag aaatcaggca agtgcttaaa 1860
aggccaacgg tccaagggat tacatctgca gtttaaaaag taaatatata ttctatcgta 1920
ttcataaaca atatctatca aatgggttac ctccaaatat gaaaatctat aacaacctat 1980
ggttgaagga atgctcagtt tcatttgcca ataaattggt ttctcataac ttgcatcaag 2040
tttaatttta agtaaagctt tttatatgta gatattttgt tgaatttgta aatacactta 2100
aaatgtagat gctatatgct tataggtgtt acatacaaat aaacatgcaa tgtttatgtt 2160
gtactgtata agaggtaagc taattaatgc agtgaatggg attggaaagc atctacttaa 2220
atatctattg ggttcccccc tccccccacc ttttttgctg tgaaactgaa atagtgaact 2280
tttctacgta ttgacagcag atttttcgat gaaatcttca gagctttgcc tatggggcac 2340
agtaggccta gtaacctggc atgtttgata tatgtaggta aagcataatt taaagtaatc 2400
ccaggtaaag atggccctaa atactttcat gtctctatat tcatttttca cagatccacc 2460
tgtctcttga aaatataaaa agacaaaaca ggtttgcctt ggcatcagag agcacaaaga 2520
ttaaaagtta ctttaaattt gccaatattt tgggagaaca ataaaactac attttttcct 2580
cttccatact ggtagatgcg aaatttatct gtgcatgaaa gggtcacttc tgtaatagtg 2640
caacagattt ggtattaaaa attaaatgtg gttttaaaag ttcctctctc ttttgtaatt 2700
tatgttccca attgagtgtg aatgtccaag taatggtgta tgtaatggta caggcaaatg 2760
tgactggatt tccctcaaaa aagtaactat taaacagtct tgatctcttt gtgactttta 2820
a 2821
<210> 38
<211> 6296
<212> DNA
<213> Homo sapiens
<400> 38
cgcgcgggcg cgggggacgg cgcaggggcc gcctggctgg agcagccaga ggggatagct 60
tcgtcgagaa cggaggacac cggcggtcca gggtcctggg cagtcgcgcc agagctgagc 120
ggagggcgcg gcgcgagaac gaatctttgt gacattctct ctcagcattc tttatcccct 180
gtttgctgaa gacttcgaca aaagctggtc ttagctgttg gcattctcct gagaaaagga 240
tagcttcaga aatcagaaaa acatttggga ggtgtctagc ccagtggacc ttctgaagag 300
caatgctaag aagacgtttg gtttaaagaa ttaaaaggaa gaacaactta agagcttctt 360
caaagtttcc cgcatgaaaa ttacttaaac gttgcacaca acgtttcaca aaatcttttg 420
tgaaagaaga aaaggaaatt cagtgtgtga gtctcagcag gagttaagct aatgcagctt 480
aaaataatgc cgaaaaagaa gcgcttatct gcgggcagag tgcccctgat tctcttcctg 540
tgccagatga ttagtgcact ggaagtacct cttgatctgg tacagcctcc aaccatcacc 600
caacagtctc caaaagatta cattattgac cctcgggaga atattgtaat ccagtgtgaa 660
gccaaaggga aaccgccccc aagcttttcc tggacccgta atgggactca ttttgacatc 720
gataaagacc ctctggtcac catgaagcct ggcacaggaa cgctcataat taacatcatg 780
agcgaaggga aagctgagac ctatgaagga gtctatcagt gtacagcaag gaacgaacgc 840
ggagctgcag tttctaataa cattgttgtc cgcccatcca gatcaccatt gtggaccaaa 900
gaaaaacttg aaccaatcac acttcaaagt ggtcagtctt tagtacttcc ctgcagaccc 960
ccaattggat taccaccacc tataatattt tggatggata attcctttca aagacttcca 1020
caaagtgaga gagtttctca aggtttgaat ggggaccttt atttttccaa tgtcctccca 1080
gaggacaccc gcgaagacta tatctgttat gctagattta atcatactca aaccatacag 1140
cagaagcaac ctatttctgt gaaggtgatt tcagtggatg aattgaatga cactatagct 1200
gctaatttga gtgacactga gttttatggt gctaaatcaa gtagagagag gccaccaaca 1260
tttttaactc cagaaggcaa tgcaagtaac aaagaggaat taagaggaaa tgtgctttca 1320
ctggagtgca ttgcagaagg actgcctacc ccaattattt actgggcaaa ggaagatgga 1380
atgctaccca aaaacaggac agtttataag aactttgaga aaaccttgca gatcattcat 1440
gtttcagaag cagactctgg aaattaccaa tgtatagcaa aaaacgcatt aggagccatc 1500
caccatacca tttctgttag agttaaagcg gctccatact ggatcacagc ccctcaaaat 1560
cttgtgctgt ccccaggaga ggatgggacc ttgatctgca gagctaatgg caaccccaaa 1620
cccagaatta gctggttaac aaatggagtc ccaatagaaa ttgcccctga tgaccccagc 1680
agaaaaatag atggcgatac cattattttt tcaaatgttc aagaaagatc aagtgcagtc 1740
tatcagtgca atgcctctaa tgaatatgga tatttactgg caaacgcatt tgtaaatgtg 1800
ctggctgagc caccacgaat cctcacacct gcaaacacac tctaccaggt cattgcaaac 1860
aggcctgctt tactagactg tgccttcttt gggtctcctc tcccaaccat cgagtggttt 1920
aaaggagcta aaggaagtgc tcttcatgaa gatatttatg ttttacatga aaatggaact 1980
ttggaaattc ctgtggccca aaaggacagt acaggaactt atacgtgtgt tgcaaggaat 2040
aaattaggga tggcgaagaa tgaagttcac ttagaaatca aagatcctac atggatcgtt 2100
aaacagcccg aatatgcagt tgtgcaaaga gggagcatgg tgtcctttga atgcaaagtg 2160
aaacatgatc acaccttatc cctcactgtc ctgtggctga aggacaacag ggaactgccc 2220
agtgatgaaa ggttcactgt tgacaaggat catctagtgg tagctgatgt cagtgacgat 2280
gacagcggga cctacacgtg tgtggccaac accactctgg acagcgtctc cgccagcgct 2340
gtgcttagcg ttgttgatgt cccaaatcct ccctttgact tagaactgac agatcaactt 2400
gacaaaagtg ttcagctgtc atggacccca ggcgatgaca acaatagccc cattacaaaa 2460
ttcatcatcg aatatgaaga tgcaatgcac aagccagggc tgtggcacca ccaaactgaa 2520
gtttctggaa cacagaccac agcccagctg aagctgtctc cttacgtgaa ctactccttc 2580
cgcgtgatgg cagtgaacag cattgggaag agcttgccca gcgaggcgtc tgagcagtat 2640
ttgacgaaag cctcagaacc agataaaaac cccacagctg tggaaggact gggatcagag 2700
cctgataatt tggtgattac gtggaagccc ttgaatggtt tcgaatctaa tgggccaggc 2760
cttcagtaca aagttagctg gcgccagaaa gatggtgatg atgaatggac atctgtggtt 2820
gtggcaaatg tatccaaata tattgtctca ggcacgccaa cctttgttcc atacctgatc 2880
aaagttcagg ccctgaatga catggggttt gcccccgagc cagctgtagt catgggacat 2940
tctggagaag acctcccaat ggtggctcct gggaacgtgc gtgtgaatgt ggtgaacagt 3000
accttagccg aggtgcactg ggacccagta cctctgaaaa gcatccgagg acacctacaa 3060
ggctatcgga tttactattg gaagacccag agttcatcta aaagaaacag acgtcacatt 3120
gagaaaaaga tcctcacctt ccaaggcagc aagactcatg gcatgttgcc ggggctagag 3180
ccctttagcc actacacact gaatgtccga gtggtcaatg ggaaagggga gggcccagcc 3240
agccctgaca gagtctttaa tactccagaa ggagtcccca gtgctccctc gtctttgaag 3300
attgtgaatc caacactgga ctctctcact ttggaatggg atccaccgag ccacccgaat 3360
ggcattttga cagagtacac cttaaagtat cagccaatta acagcacaca tgaattaggc 3420
cctctggtag atttgaaaat tcctgccaac aagacacggt ggactttaaa aaatttaaat 3480
ttcagcactc gatataagtt ttatttctat gcacaaacat cagcaggatc aggaagtcaa 3540
attacagagg aagcagtaac aactgtggat gaagcgatgg caagccggca ggtggatatt 3600
gcaactcagg gctggttcat tggtctgatg tgtgctgttg ctctccttat cttaattttg 3660
ctgattgttt gcttcatcag aagaaacaag ggtggtaaat atccagttaa agaaaaggaa 3720
gatgcccatg ctgaccctga aatccagcct atgaaggaag atgatgggac atttggagaa 3780
tacagtgatg cagaagacca caagcctttg aaaaaaggaa gtcgaactcc ttcagacagg 3840
actgtgaaaa aagaagatag tgacgacagc ctagttgact atggagaagg ggttaatggc 3900
cagttcaatg aggatggctc ctttattgga caatacagtg gtaagaaaga gaaagagccg 3960
gctgaaggaa acgaaagctc agaggcacct tctcctgtca acgccatgaa ttcctttgtt 4020
taatttttaa gctctttgcc aatattccat ttctctagaa tgtttatcct aagcacttgt 4080
ttgtcagccc tctcatacta tgaacatatg ggtagagagt atattttctg ctgtatgtta 4140
gtattatgag aatagttaca gcaaaaacat aactcagtca aatgatatgt taatatgaac 4200
tggaatgcaa agtgcatact ttttcattca aaatgggtat tcttgatttc ctcagaactg 4260
ataaaaaata atgcaacatc accaacagat cctgttattt cctctgcagg atacagttca 4320
atatgatgca tgaaaaatgc tccacattta aaggacatac ccgtgtatgt tatgaaaaca 4380
tggtttgata ctttgtttat actaccctca gctgaacccc tatatatgaa ttccgttttc 4440
attgtcaaga atgttactgt agtattctct agaacttcaa tgtctttgtg gacattgttg 4500
tgaaattggt gactatgtat agctgtcgtt agtctttttg ggagactgtt aggaacagtt 4560
tgtacagtat atacttgcta aatgagttca ttatgacagt cacattgctg atgcttactg 4620
agaactatta cctactcttg gctcctgtta ctccgtaggc ttcttaatct tccaggcatt 4680
acagcagcac agtgttctac tttttacatc atttctatgt tcggttgttt ttaggcataa 4740
acaatgtgta ttgcagtgca tttcggcatt tgtgccatac tgaaagaatc aaaaacaaat 4800
catccaaatt aaatttcaaa cattatttca gagaacacag ggcaagacac atacagtgcc 4860
ttcagatatt aagcattcca caacatcgtg cattctgtat cagctggtcc agtccattct 4920
gggtcctaga ttactgtcat tgtctaaaag taacttttaa aaagcagagt tcatgaaaac 4980
tgcaatgctg ggaaaagaag gaaacatgaa aataaaaata agacagttta ttagaaatag 5040
catttcctca taagcataaa aagaaaatct ttgttgccaa ctgaagcaca tgatgatttt 5100
gtggtccttt atggtttcta ttacattcag taagaaagat gtcaacatgc tagaaaatta 5160
attttaaaac taagttattc caacactaaa agcatacaac agcatgccaa cagtaatata 5220
ttattctcca agactttacc tatgtaagtg ttcaaaactc tgcagcatta aacaacgtgt 5280
atgcaaattg ttatggatac atttcagaat ctaagaaatc aggcaagtgc ttaaaaggcc 5340
aacggtccaa gggattacat ctgcagttta aaaagtaaat atatattcta tcgtattcat 5400
aaacaatatc tatcaaatgg gttacctcca aatatgaaaa tctataacaa cctatggttg 5460
aaggaatgct cagtttcatt tgccaataaa ttggtttctc ataacttgca tcaagtttaa 5520
ttttaagtaa agctttttat atgtagatat tttgttgaat ttgtaaatac acttaaaatg 5580
tagatgctat atgcttatag gtgttacata caaataaaca tgcaatgttt atgttgtact 5640
gtataagagg taagctaatt aatgcagtga atgggattgg aaagcatcta cttaaatatc 5700
tattgggttc ccccctcccc ccaccttttt tgctgtgaaa ctgaaatagt gaacttttct 5760
acgtattgac agcagatttt tcgatgaaat cttcagagct ttgcctatgg ggcacagtag 5820
gcctagtaac ctggcatgtt tgatatatgt aggtaaagca taatttaaag taatcccagg 5880
taaagatggc cctaaatact ttcatgtctc tatattcatt tttcacagat ccacctgtct 5940
cttgaaaata taaaaagaca aaacaggttt gccttggcat cagagagcac aaagattaaa 6000
agttacttta aatttgccaa tattttggga gaacaataaa actacatttt ttcctcttcc 6060
atactggtag atgcgaaatt tatctgtgca tgaaagggtc acttctgtaa tagtgcaaca 6120
gatttggtat taaaaattaa atgtggtttt aaaagttcct ctctcttttg taatttatgt 6180
tcccaattga gtgtgaatgt ccaagtaatg gtgtatgtaa tggtacaggc aaatgtgact 6240
ggatttccct caaaaaagta actattaaac agtcttgatc tctttgtgac ttttaa 6296
<210> 39
<211> 2581
<212> DNA
<213> Homo sapiens
<400> 39
agcgcctgcg cactgcgccg ccggctgggg tgctgggggc ggggcagggg caggtgtagc 60
ctctgtgcct cgttgtcccc tggcgctacc cggacatctc tcagggtgcc ggcaccatga 120
agatctggac ttcggagcac gtctttgacc acccgtggga aactgttaca acagctgcaa 180
tgcagaaata cccaaaccct atgaacccaa gtgtggttgg agttgatgtg ttggacagac 240
atatagatcc ctctggaaag ttgcacagcc acagacttct cagcacagag tggggactgc 300
cttccattgt gaagtctctt attggtgcag caagaacgaa aacatatgtg caagaacatt 360
ctgtagttga tcctgtagag aaaacaatgg aacttaaatc tactaatatt tcatttacaa 420
acatggtttc agtagatgag agacttatat acaaaccaca tcctcaggat ccagaaaaaa 480
ctgttttgac acaagaagcc ataattaccg tgaaaggagt tagcctcagc agttaccttg 540
aaggactgat ggcaagtacg atatcctcaa atgctagtaa aggccgagaa gcaatggaat 600
gggtaataca taaattaaat gctgagattg aagaactgac agcctcagca agaggaacca 660
taaggactcc aatggcagca gcagcgtttg cagagaagtg atcgtgacag ttggtagaca 720
acatcgggta ctccaggtct ctccaaactg actatatatt tatttgttat tttaaaaata 780
caactatatt ttgggtagtt tttttttttt tttttttgat aagttggtgt aaggctatgt 840
gacttgatca aaacagatgc agggcctcta aataaaaggg atcatctgaa attaatgttg 900
tttgaaatta ctatctgatt ttgagggttc cagtatttct gtgaaaattc aacaagaact 960
ccttggaaac tggtattgat attcagtctc cttaaggtag atttttcaag cttttcatac 1020
attggaactc cacctgactt tggaccaacc ccagaacaga gcagagccac ctcctataga 1080
cgcccattgc cctgctgctg tacacttcag cagcttgcac aagggagctc acttaaaagg 1140
agaaattgtg tagttttaaa atatattttg tgtaaaatac cttactatgc tataaaccac 1200
cattaaaaac cagtgttttg atttggtact taaatatttt tggagtgaaa attatcacta 1260
aagtaacatg actccaacaa aagtatggtt tcattataaa agagtactgt attgatttgc 1320
ccaagttttg taacttagta aaggtattaa cttccttgga tttgtacttt gtgatttagt 1380
atgctgtatc gtgggctggt tatgttaact gaaaaaaata aagtcattac ctgagttttg 1440
cagtgctcta acttaaacag aagaacagct gttcacatct tttagcattt tacatttgcc 1500
taacttaaaa attgccatgt gtcaaaatca tggttttgta attgctaagg catgatatgt 1560
caggttattt gaatataatt actttttgaa gtaattgtga ccacaaaaca tcttttttac 1620
atgaaggagc tgtgtatcat ttgaaattac tcaaatgatg tcttgctctg aggcataaat 1680
cccaggtact tagtgttttt aataatatgg tgccactgca ggatttgggg gcggtgggga 1740
agaacaagca taatggtagg gggaggcttg gcctgaaact aaccactgag tgaattgcac 1800
tgcaggtttt acttaacggg aattccttat ttgggatgtc aagagggcag ctgcaaactg 1860
aaaaacaatc cagtaaatgt actttgtttt atgtattgta gcaggcaatt aactactaaa 1920
taatagcttt gacatttgca attgttgcat agagactatt tttgctagaa gatgattagc 1980
tcttgccttt attttacagt gcttagtgtg ataaacttct agtcatgttt cctatccaag 2040
agaccagtta atatatgtac ataaaccaca gaaatagtat aacacactat ttttaaatta 2100
tcgttttcct acttaaattt tgtttagctt aagacttctt aggacatttg taaaagcagg 2160
ttaaatttaa taaggtttct gatttttttt tgtaaccgga gatagttttt acaagtgaaa 2220
taacatttca gctaaataaa acatcgctaa ataattgata tttgatgaaa atctgctttg 2280
tataatttct gtaaattatc cttgttctga aaaaggtgta atgccctaat atttttaaat 2340
ccttatcctt tgatttttta aaaactgacc tattgataaa actataaatt ttcattttcc 2400
agtgcagtta gttacctttt taaacataaa tgcacaacaa gcaaatgaat ttaagagaac 2460
taaactggaa taagtgttca taaatgaaac ccttggacta tttaataaag ttgaaatgtg 2520
aattaaggaa aacttttgtt aataaaaact ttcttttaag tgaaaaaaaa aaaaaaaaaa 2580
a 2581
<210> 40
<211> 2150
<212> DNA
<213> Homo sapiens
<400> 40
agctccggcc ccgaccggaa gccccaccgc accgtcaggg acgcggactc gggagtgcgc 60
acattcgcag cccgggcagc cctgctgcgc accgggcctc gcgccccgcg ccccgcgccc 120
cgcgccccgc gccccgcacc ggcctccagg atcatgtggt atgtcagcac caggggcgta 180
gccccacggg tcaactttga gggggccctc ttctctggct atgcacctga cgggggcctc 240
tttatgcctg aagagctccc acagttggac agagggaccc tgtgccagtg gagcacactc 300
tcctatcctg gcctggtgaa ggagctgtgt gccctcttca ttggctctga gctccttcca 360
aaagatgaat taaatgatct gatcgaccga gccttcagca gattccgtca cagagaagtg 420
gtccatctgt ccaggttgag gaatgggctg aacgtgttgg agctgtggca tggcgtcaca 480
tatgcattta aggacctgtc cctgtcctgc acaacacagt tcctgcagta cttcctggag 540
aagagggaga agcacgtcac tgtggttgta ggaacatctg gggacacagg aagtgctgcc 600
attgagagtg ttcaaggggc aaagaacatg gacattatcg ttctgctgcc caaaggtcac 660
tgcacaaaga ttcaggagct ccagatgaca acggtgctga agcagaacgt acatgtgttt 720
ggagtggagg gaaacagcga tgagctcgat gagccgatca agactgtgtt tgccgatgtg 780
gcttttgtca agaagcacaa tctgatgagc ctgaattcga tcaactggtc ccgggtcctg 840
gtgcagatgg cccatcactt ctttgcttac ttccagtgta cgccatcctt ggacacacat 900
cccctacccc tggtggaggt ggttgtgcca acaggggctg ccggtaacct tgcagctggg 960
tacattgctc aaaagatagg cctgcccatc cgtctggtcg tggcagtgaa ccgcaatgac 1020
atcatccaca ggactgtcca gcagggagac ttctctctct ctgaggctgt taaatcaacc 1080
ttggcatcag ctatggacat tcaggtgccc tacaacatgg agagggtgtt ctggctgctc 1140
tctggctctg acagccaggt gacaagagcc ctcatggagc agtttgaaag gacccaaagt 1200
gtgaatctgc ccaaggaact gcacagcaag ctttcagagg cagtgacatc cgtgtcagtg 1260
tcggatgaag ccatcaccca gaccatgggc cgctgctggg atgagaacca gtacttgctg 1320
tgcccccact cagcggtggc cgtgaactac cattaccagc agatagacag gcagcagccc 1380
agcactcccc ggtgctgcct cgcccctgcc tctgcagcca agttcccgga agctgtcctg 1440
gctgctggcc tgacccctga gactcccgcg gagatcgtag ccctggagca caaggagaca 1500
cgctgcaccc tgatgcggag aggtgacaac tggatgctga tgcttcggga caccattgag 1560
gaccttagcc gacagtggag gagtcatgcc ctcaacacct cccagtagcc tggctggagg 1620
tggctttctt taggcttcag atcccaggaa gatgcacctt ctgagctgcc ttgtgcaccc 1680
tccccattaa gcgtaggtta ggaggtttcc gggaggctgc tcagctggat ctggagccag 1740
ctggctttgc tccgttccct ggctagtctg tgcctggtca ccagggaggc tgagtgaggg 1800
gctgtgaaca gttgccggaa gcaccccctc cctccccggc ccgtgcagca gtgtctgagc 1860
tgtagtgaaa gtttcagggc ctgcaaaaga agaggcttgg gcacaggact gaccatggct 1920
ccaggggttt aggaccccag acctgtgaag gtgggagcag ctcaccacct tcacgcaggc 1980
tttgtatgtt ctctgagcct tagttgattt tggcccccaa accaaatcca aaggttctgg 2040
cccaccttgt cagaggcttc caccctgctc acatgttggg aatccctgga ataaaatgct 2100
tgttcagtgt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2150
<210> 41
<211> 2368
<212> DNA
<213> Homo sapiens
<400> 41
agccgccaca ctttcccaag cccgcaggcg ccccccccaa caccagcgct gcacccccga 60
cccattcccc gcggccccct ccaggagaaa aaatgaaacc agactggccg aggagggggg 120
cggcagggac cagggtgcgg agcagaggtg agggagacgg gacttacttt gcgaggcgcg 180
gtgcagggcg ccgccgacga gaaataaagg ccccgatacg ggctgcctgg agccccccga 240
gcgcagcaat gtcagggctc cagtccgggc ggcgttggcg gccgcagggg acggggacgg 300
gcgcgcgtgc ggcgggcgct ctcgctgcgc tccggctcgg gccccggctc cgcgcggctc 360
cgctcctggc tcccctctgg ctcctggcac caactccgga cagtcacatg acgccggcgc 420
cgctcgctct gcgagcctcc cggggctggc gggagaataa cttgtctgac taccagtatt 480
cttggatgca gaagtgctga agatgagcac acacacgtac ggagaatttc tggagaattc 540
agctgctcag aacaagaact gagatccaga gagatgatga ctttgcccat agaccaaaca 600
aagaaataca tgtttcagtc ctgtgtcctc ctgctatgtg tgtccggaat tggtgggttc 660
ttggtctcac tgactccaag aatgaagctg cggaccctcg cggaccgtgt gtgaatgcct 720
gctctgtgag ccctcagaat ctactggctg aatgagtgcg tggaggaaat gtgctcagag 780
ctgctgtgtg tcatcctgtg tttgaagtgc tcctgcagct atcattcatc cagttaagaa 840
tttgaagaag tgtgtgcaca aagacggagt ctcactctgt tgcccaggct ggagtgcagt 900
ggcacaatct cggctcactg caacctctac ctcctggatt caagcggttt tcctgcctca 960
gcctccagag taacagggat tacaggcata ctccaccttg ccctgctgat tttgtatttt 1020
tagtagagac aagagtttca ccatgttggc caggctggtc ttgaactcct gacctcaagt 1080
gatccactgc ctcagcctcc caaagtgctg ggattatagg cgtgagccac tgcgcctggc 1140
caaatgctct actttttaat caatgttttc caaaataggg atttttgcta tgtgctttag 1200
aaattagaga acaaacggtg ataatatatg ctaaacttaa aattagtatg cctcctttta 1260
tagacaacaa gaactttgtc acttcccagt ttgtcttgtc attcaggagg ctcagagcta 1320
cgatctgtgc ccactcgtgc tgcctcttct taactttgat ttcctgaagc agcgatttca 1380
tctccgtttc ccctcatcac ctgttctttt aactgtttaa aaacagcatt acatgttgtt 1440
gcaagtggcc tcaaattctt tttggtagaa gggaaattgt aatccatgag aagaaaaaaa 1500
ttttcctaac tattctcagg tgtgtttaag ggctgcattc catgatgcta tcagtgcctt 1560
ctttcagctc acaggatatc ggccatgtta atgagtctga tgttgctagt atcacaggca 1620
ccggaaaata tgcacattat gctggagcat tagaatgcaa cagaaagagc cctgggcttg 1680
gagtatgcag aactggttct tgttacaact cctcttacta gtgggctctg gaagaaaaca 1740
cattgaattc atgatcatgg ttaacctttg gagagagaga ggagaccagg atgaaggagc 1800
cagtcgaaga tcctgttcaa gtgtacactg agccagcagg ttcaccagaa agctattgag 1860
cgtttgctgg aacacattat gcagggtgaa tttcttctgg aatgttgcca aggatttttt 1920
atgcttctgt ggcaggcatt tcttgaacat tgtcatttag ccaagcaaag aagattttct 1980
taaaggatag aaagtgttta aaaatttttg tttgtttgaa gataggttaa atggctatat 2040
gatctcagga taagacagag aaaatcactt atttctctaa gtgatctgat taggttagtg 2100
atgttttgcc tttaaacaga ttcatcatta ttcctaaagt attgctgtat taatactgtc 2160
ttctagaaag tatccaccag tgcctacttt tcttcgatat cattagctgt ttttcgaaac 2220
tgaatttgct cttcagagat ttctcatatg tttgcgtata aggaactact ggtaatagcc 2280
aagaaaattt ggaggtgcag agaacatgct gaaacagaat ttttcacttt caattctaga 2340
actatgccat aaaaaaaaag gaaaatgt 2368
<210> 42
<211> 1928
<212> DNA
<213> Homo sapiens
<400> 42
cctgcctcag cctccagagt aacagggatt acaggcatac tccaccttgc cctgctgatt 60
ttgtattttt agtagagaca agagtttcac catgttggcc aggctggtct tgaactcctg 120
acctcaagtg atccactgcc tcagcctccc aaagtgctgg gattataggc gtgagccact 180
gcgcctggcc aaatgctcta ctttttaatc aatgttttcc aaaataggga tttttgctat 240
gtgctttaga aattagagaa caaacggtga taatatatgc taaacttaaa attagtatgc 300
ctccttttat agacaacaag aactttgtca cttcccagtt tgtcttgtca ttcaggaggc 360
tcagagctac gatctgtgcc cactcgtgct gcctcttctt aactttgatt tcctgaagca 420
gcgatttcat ctccgtttcc cctcatcacc tgttctttta actgtttaaa aacagcatta 480
catgttgttg caagtggcct caaattcttt ttggtagaag ggaaattgta atccatgaga 540
agaaaaaaat tttcctaact attctcaggt gtgtttaagg gctgcattcc atgatgctat 600
cagtgccttc tttcagctca caggatatcg gccatgttaa tgagtctgat gttgctagta 660
tcacaggcac cggaaaatat gcacattatg ctggagcatt agaatgcaac agaaagagcc 720
ctgggcttgg agtatgcaga actggttctt gttacaactc ctcttactag tgggctctgg 780
aagaaaacac attgaattca tgatcatggt taacctttgg agagagagag gagaccagga 840
tgaaggagcc agtcgaagat cctgttcaag tgtacactga gccagcaggt tcaccagaaa 900
gctattgagc gtttgctgga acacattatg cagggtgaat ttcttctgga atgttgccaa 960
ggatttttta tgcttctgtg gcaggcattt cttgaacatt gtcatttagc caagcaaaga 1020
agattttctt aaaggataga aaatgtttaa aaatttttgt ttgtttgaag ataggttaaa 1080
tggctatatg atctcaggat aagacagaga aaatcactta tttctctaag tgatctgatt 1140
aggttagtga tgttttgcct ttaaacagat tcatcattat tcctaaagta ttgctgtatt 1200
aatactgtct tctagaaagt atccaccagt gcctactttt cttcgatatc attagctgtt 1260
tttcgaaact gaatttgctc ttcagagatt tctcatatgt ttgcgtataa ggaactactg 1320
gtaatagcca agaaaatttg gaggtgcaga gaacatgctg aaacagaatt tttcactttc 1380
aattctagaa ctatgccata aaaaaaaagg aaaatgtaaa aatgtcttta tattagagca 1440
gatattttaa aagtattgca aattcaatga taaattctaa ggttaaaatt ggacacataa 1500
aaaatacaat atataaatat ctccccagaa attattatct aatgaatagt aaaagctgac 1560
tacaaaccat gtcattttaa caagggttta aatagtacca agattctcat catatgctct 1620
gggataccca gtgatgtaca agggttctct ctaaacatgg ggaggaaaaa tttcaaatat 1680
aaagatttga atcttgtctt tgccattcac tagctgtgtg atcttgggta agttacctgg 1740
tttctctgag cttcagtgtc atctgtaaaa caggaataat aatacctagc tcagaggcgg 1800
gtgtggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcacta 1860
ggtcaggagt ttgagaccag cctggccaag atggtgaaat cctgtctcta cttaaaaaaa 1920
aaaaaaaa 1928
<210> 43
<211> 1928
<212> DNA
<213> Homo sapiens
<400> 43
cctgcctcag cctccagagt aacagggatt acaggcatac tccaccttgc cctgctgatt 60
ttgtattttt agtagagaca agagtttcac catgttggcc aggctggtct tgaactcctg 120
acctcaagtg atccactgcc tcagcctccc aaagtgctgg gattataggc gtgagccact 180
gcgcctggcc aaatgctcta ctttttaatc aatgttttcc aaaataggga tttttgctat 240
gtgctttaga aattagagaa caaacggtga taatatatgc taaacttaaa attagtatgc 300
ctccttttat agacaacaag aactttgtca cttcccagtt tgtcttgtca ttcaggaggc 360
tcagagctac gatctgtgcc cactcgtgct gcctcttctt aactttgatt tcctgaagca 420
gcgatttcat ctccgtttcc cctcatcacc tgttctttta actgtttaaa aacagcatta 480
catgttgttg caagtggcct caaattcttt ttggtagaag ggaaattgta atccgtgaga 540
agaaaaaaat tttcctaact attctcaggt gtgtttaagg gctgcattcc atgatgctat 600
cagtgccttc tttcagctca caggatatcg gccatgttaa tgagtctgat gttgctagta 660
tcacaggcac cggaaaatat gcacattatg ctggagcatt agaatgcaac agaaagagcc 720
ctgggcttgg agtatgcaga actggttctt gttacaactc ctcttactag tgggctctgg 780
aagaaaacac attgaattca tgatcatggt taacctttgg agagagagag gagaccagga 840
tgaaggagcc agtcgaagat cctgttcaag tgtacactga gccagcaggt tcaccagaaa 900
gctattgagc gtttgctgga acacattatg cagggtgaat ttcttctgga atgttgccaa 960
ggatttttta tgcttctgtg gcaggcattt cttgaacatt gtcatttagc caagcaaaga 1020
agattttctt aaaggataga aaatgtttaa aaatttttgt ttgtttgaag ataggttaaa 1080
tggctatatg atctcaggat aagacagaga aaatcactta tttctctaag tgatctgatt 1140
aggttagtga tgttttgcct ttaaacagat tcatcattat tcctaaagta ttgctgtatt 1200
aatactgtct tctagaaagt atccaccagt gcctactttt cttcgatatc attagctgtt 1260
tttcgaaact gaatttgctc ttcagagatt tctcatatgt ttgcgtataa ggaactactg 1320
gtaatagcca agaaaatttg gaggtgcaga gaacatgctg aaacagaatt tttcactttc 1380
aattctagaa ctatgccata aaaaaaaagg aaaatgtaaa aatgtcttta tattagagca 1440
gatattttaa aagtattgca aattcaatga taaattctaa ggttaaaatt ggacacataa 1500
aaaatacaat atataaatat ctccccagaa attattatct aatgaatagt aaaagctgac 1560
tacaaaccat gtcattttaa caagggttta aatagtacca agattctcat catatgctct 1620
gggataccca gtgatgtaca agggttctct ctaaacatgg ggaggaaaaa tttcaaatat 1680
aaagatttga atcttgtctt tgccattcac tagctgtgtg atcttgggta agttacctgg 1740
tttctctgag cttcagtgtc atctgtaaaa caggaataat aatacctagc tcagaggcgg 1800
gtgtggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcacta 1860
ggtcaggagt ttgagaccag cctggccaag atggtgaaat cctgtctcta cttaaaaaaa 1920
aaaaaaaa 1928
<210> 44
<211> 2305
<212> DNA
<213> Homo sapiens
<400> 44
gcaaaagcgc tagggttgca agtggcacca gagacgtgcc cttgtcccgg ggtccatttg 60
agggtgagcg tgttggtgcc gagctgtttt tttgttttgt tttgttttgt tttgtttttg 120
agaccgaatc tcgttctgtc gcccaggctg gaatgcagtg gtgtgatctt ggctcactgc 180
aacctccacc ttccgggttc aagtgaatct cctgcctcag cctcctgagt agctgggatt 240
actggcaccc accaccacga ccagctaatt tttgtatttt tagtagagac gggttttcac 300
catgttggcc aggatggtct caatctcctg acctcaggcg atctgccttc ctcagcttcc 360
caaagtgctg ggattacagg tgtgagccac cgcacccggc cagtgctgag ctgttttgac 420
aacttggacc ccgggtcctc tgtgggtagg aaaatcagct ccctctttgc tcctctgggg 480
cagctgcacc tcgggccagc tttctgcctg tctgcctgcc ggcactgctg ggtcgctgta 540
cccaaacgca cagccggtgc cccgtgctag aaggtcttca gtttccagaa gagccaaagc 600
atctttggac ctacctaggg aaggacctgc ctgtgacctt tgccctgtcc tggagggtcc 660
agctttgggc tgaatggcag cacccacgct gggccgtctg gtgctgaccc acctgctggt 720
ggcccttttt ggcatgggct cctgggctgc tgtgaacggg atctgggtgg agctgcctgt 780
ggtggtaaaa gaccttccag agggttggag cctcccctca tacctctctg tggttgtggc 840
gctgggaaac ctgggtctgc tggtggtgac cctgtggagg cggctggccc cgggcaaggg 900
cgagcaggtc cccatccagg tggtacaggt gctgagtgta gtgggcacag ccctgctggc 960
ccctctgtgg caccacgtgg ccccagtggc agggcagctc cactctgtgg ccttcctaac 1020
tctggccttg gtgttggcaa tggcctgttg tacctctaat gtcactttcc tgcccttcct 1080
gagccacctg ccacctcctt tcttacggtc tttcttcctg ggtcagggtc tcagtgccct 1140
actcccctgt gtgctggccc tagtgcaagg tgtgggccgc ctcgagtgcc caccagcgcc 1200
caccaatggc acctctgggc ctcccctcga cttccctgag cgttttcctg ccagcacctt 1260
cttctgggca ctgactgccc ttctggtcac ttcagctgcc gccttccggg gtctcctgtt 1320
gctgttgcca tcactaccct ctgtaaccac agggggctca gggcctgaac ttcaactggg 1380
atccccagga gcagaggagg aagagaagga ggaagaagag gctttgccat tgcaggagcc 1440
accgagccag gcagcaggca ccatccctgg cccagaccct gaggtccatc agctgttctc 1500
agcccatggt gccttcctgc tgggcctgat ggccttcacc agtgccgtga ccaatggcgt 1560
gctgccttct gtgcagagct tttcctgttt gccctatggg cgcctggcct accacctggc 1620
tgtggtgctg ggcagtgccg ccaaccccct tgcctgcttc ctggccatgg gcgtgctgtg 1680
caggtccctg gcagggctgg ttggtctttc tctgctgggc atgctctttg gggcctacct 1740
gatggcactg gcaatcctga gcccctgccc acccctggtg ggcaccactg caggggtggt 1800
ccttgtggtg ctgtcgtggg tgctgtgtct gtgtgtgttc tcatatgtga aggtggctgc 1860
aagctccctg ctgcatggtg ggggtcggcc ggcattgctg gcagctggtg tggccatcca 1920
agtgggctcc ctgcttggtg ccggtgccat gttccctccc accagcatct accacgtgtt 1980
tcaaagcaga aaggactgtg tagacccctg tggcccctga gcctgggcag gtggggaccc 2040
aactccaccc cacctgtctt catcgtgagg ctgccacagt gcctgactac ttgtggccca 2100
ggcaggcttc ccccaacaca ggaacgctca tggacacctg cacactccac agaagacgtt 2160
ggcatgtgag gccagggtgg gcaccaaaga ccaggcccag agccagggga caggttgggg 2220
ctgtgggctt ggacccaggg cctgagacct ttgtgggatt tgtgcaataa agtgttttta 2280
tttaaaacca aaaaaaaaaa aaaaa 2305
<210> 45
<211> 4315
<212> DNA
<213> Homo sapiens
<400> 45
ggcggcggct ggcggcggcg gtggggcggg gcctgggctg tcagccggcc taggaggagg 60
aaggagcctg cggcgtgcag tgtgaggggc gggacccggc tgccggcggt gggtctagct 120
gggggaggtc gggccatgct ggtgggccag ggcgcggggc cgctggggcc cgcggtggtc 180
accgccgcgg tggtgctgct gctgagcggc gtggggccgg cgcacggctc ggaggacatc 240
gtggtgggct gcggtggctt cgtcaagtcg gacgtggaga tcaactactc tctcatcgag 300
ataaagctgt acaccaagca tgggactttg aaataccaga cagactgtgc ccctaataat 360
ggttacttta tgatcccttt gtatgataag ggggatttca ttctgaagat tgagcctccc 420
ctagggtgga gttttgagcc gacgaccgtg gagctccatg tggatggagt cagtgacatc 480
tgcacaaagg gtggggacat caactttgtc ttcactgggt tctctgtgaa tggcaaggtc 540
ctcagcaaag ggcagcccct gggtcctgcg ggagttcagg tgtctctgag aaacactggg 600
accgaagcaa agatccagtc cacagttaca cagcctggcg gaaagtttgc attttttaaa 660
gttctgcctg gagattatga aatcctcgca actcatccaa cctgggcgtt gaaagaggca 720
agcaccacag tgcgtgtaac caactccaat gccaatgcgg ccagtcccct catagttgct 780
ggctacaatg tgtctggctc tgtccgaagt gatggggagc ccatgaaagg cgtgaagttt 840
cttctctttt cttctttagt aactaaagag gatgtcctgg gctgcaatgt ctcaccagtg 900
cctgggttcc agccccaaga cgagagtctg gtgtatttgt gctacacggt ctccagagaa 960
gatggctcgt tctctttcta ttccttgcca agtgggggct acactgtgat tccgttctat 1020
cgaggggaga ggattacctt tgatgtggcg ccttccagac ttgacttcac agtggagcat 1080
gacagcttga aaatcgagcc cgtgttccac gtcatgggat tctccgtcac cgggagggtc 1140
ttgaacggac ccgaaggaga tggtgttcca gaagcagtag tcaccctgaa taaccaaatc 1200
aaagttaaaa caaaagctga tggctcattc cgccttgaga acataaccac agggacatac 1260
accatccatg ctcagaaaga gcacctctac tttgaaacgg tcaccatcaa aattgcacca 1320
aacacacctc agctggctga cattgttgca acagggttca gtgtctgtgg tcagatatca 1380
atcattcgct tccccgacac cgtcaagcag atgaataaat acaaagttgt cctgtcatct 1440
caagacaagg acaagtcttt ggtcaccgtg gagacagatg ctcatggatc attttgtttt 1500
aaagcaaacc cagggactta caaagtgcag gtgatggttc ctgaggcaga aaccagagca 1560
gggctgacgt tgaaacccca gacatttcct cttactgtga ccgacaggcc tgtgatggat 1620
gtggcctttg tacagttctt ggcatcagtt tctgggaaag tctcttgttt ggacacctgt 1680
ggtgacttgc tggtgactct acagtccctg agccgccagg gtgagaagcg gagcctccag 1740
ctctccggca aggtcaacgc catgactttc acctttgaca acgtgctccc tggaaaatac 1800
aaaataagca tcatgcatga ggattggtgc tggaagaaca agagcctgga ggtggaagtg 1860
ctggaggatg acgtgtctgc agttgagttc aggcagacgg gctacatgct gagatgttcc 1920
ctgtctcacg ccatcactct ggaattttat caggatggaa atgggcgtga gaatgtgggg 1980
atttataacc tctccaaagg agtcaaccga ttctgcctgt ccaagcctgg tgtgtacaaa 2040
gtgacccctc gctcctgcca ccggtttgag caagcgttct acacctatga cacgtcttca 2100
cctagtatct tgacattgac agccattcgc caccatgtcc ttggaactat caccaccgac 2160
aaaatgatgg atgtcactgt gactatcaag tcttccatcg acagtgaacc cgccttggtc 2220
ttaggccctc tgaagtctgt gcaggagctg cggagggagc agcagctggc tgagatcgag 2280
gcccgcaggc aggagaggga gaaaaacggc aatgaggaag gtgaagaaag aatgaccaag 2340
cctcctgtgc aggagatggt agatgagtta caaggcccct tctcgtatga tttctcttac 2400
tgggcgcggt ctggagagaa aatcactgtt acaccgtcat ctaaagagct gctcttttat 2460
cccccttcaa tggaagccgt tgtcagtgga gaaagctgcc cagggaagct gatcgagatc 2520
cacgggaagg caggcctgtt tttagaaggc cagatccacc ccgagttgga aggagtcgag 2580
attgtcatca gtgaaaaggg ggcaagttca ccgctgatca cagtctttac tgatgacaaa 2640
ggtgcctaca gtgttggccc cctgcacagt gacctggagt acacggtgac ctcacagaag 2700
gagggctatg ttctgactgc agtggaagga accatcggag acttcaaggc ctatgccctg 2760
gcaggcgtaa gctttgagat aaaagctgag gatgaccagc ccctcccggg agtcctctta 2820
tccctgagtg gtggcctgtt tcgttccaac ctcttgaccc aggacaacgg cattctgaca 2880
ttctcaaacc tgagccctgg ccagtattac ttcaaaccca tgatgaagga gttccggttt 2940
gagccatcct cacagatgat cgaggtgcag gaaggccaga acctgaagat caccatcacg 3000
gggtaccgaa ccgcttacag ttgctatggc acagtgtctt ccttaaacgg agagcccgaa 3060
caaggggttg ccatggaagc ggtgggccag aacgactgca gcatttacgg agaagacacc 3120
gtgacagacg aagagggcaa gttcagatta cgtggattgc tgccgggatg tgtgtaccac 3180
gttcagctca aggcagaagg caacgaccac attgagcggg cgctccccca ccatagggtg 3240
attgaggttg ggaataatga catcgatgat gtaaacatca tagttttccg gcagattaat 3300
caatttgatt taagtggaaa tgtgatcact tcctctgaat accttcctac gttatgggtc 3360
aagctttaca aaagcgaaaa cctcgacaat ccaatccaga cagtttccct tggccagtcc 3420
ctgttcttcc atttcccccc actgctcaga gatggcgaga actatgttgt gcttctggac 3480
tccacactcc ccagatccca gtatgactac atcttgcctc aagtttcttt caccgcagtg 3540
ggctaccata aacacatcac cttgattttt aatcccacga ggaagctgcc tgaacaggac 3600
atcgcacaag gatcctacat tgccctgcca ttgacgctgc tggttctgct ggccggttac 3660
aaccatgaca agctcattcc tttgctgctg cagttgacaa gccggctaca gggagtcggc 3720
gcgctcggcc aggcagcctc tgacaatagc ggcccagaag atgcaaagag acaagccaag 3780
aaacagaaga caaggcggac gtgaggagga aggggacagt tgcagtctca cttgggacag 3840
gccacagcca ggggtccggc cactacccgc ccgtgggata aaagccaaaa gcatgcgtca 3900
gctaacttca gcctgtgctg ctgggcccgc accccatgtc ccttgtcact gtggcatcct 3960
gcacccatcc tcacccctcc gtagagcccc tcgtgcaatg caatgaatgg accctcctgt 4020
cactctgctg aacagaattt attttctgag tcaaatataa tttattatta tttttgtcaa 4080
agaagtattt aagctgtgct gtggtgtgag aatgtcattc ttgatcttca gccttcgttt 4140
gcaagaagag ttccagttga tgtggtgttt ggttccatgg cggggtaccc tagggattca 4200
tctgttttct tcacttccct ttgcatctga gatcctgctg gaaaccacgg caacctgtat 4260
ccactattag gaggtaaaaa tcaataaaat ggcccattca tttgtgttgt agctc 4315
<210> 46
<211> 1124
<212> DNA
<213> Homo sapiens
<400> 46
ccagggcgcg acgcgctgcg gctcagcgac gcggcttcta gaaccgggtg attgaactaa 60
accttcgccg caccgagttt gcagtacggc cgtcacccgc accgctgcct gcttgcggtt 120
ggagaaatca aggccctacc gggcctccgt agtcacctct ctatagtggg cgtggccgag 180
gccggggtga ccctgccgga gcctccgctg ccagcgacat gttcaaggta attcagaggt 240
ccgtggggcc agccagcctg agcttgctca ccttcaaagt ctatgcagca ccaaaaaagg 300
actcacctcc caaaaattcc gtgaaggttg atgagctttc actctactca gttcctgagg 360
gtcaatcgaa gtatgtggag gaggcaagga gccagcttga agaaagcatc tcacagctcc 420
gacactattg cgagccatac acaacctggt gtcaggaaac gtactcccaa actaagccca 480
agatgcaaag tttggttcaa tgggggttag acagctatga ctatctccaa aatgcacctc 540
ctggattttt tccgagactt ggtgttattg gttttgctgg ccttattgga ctccttttgg 600
ctagaggttc aaaaataaag aagctagtgt atccgcctgg tttcatggga ttagctgcct 660
ccctctatta tccacaacaa gccatcgtgt ttgcccaggt cagtggggag agattatatg 720
actggggttt acgaggatat atagtcatag aagatttgtg gaaggagaac tttcaaaagc 780
caggaaatgt gaagaattca cctggaacta agtagaaaac tccatgctct gccatcttaa 840
tcagttatag gtaaacattg gaaactccat agaataaatc agtatttcta cagaaaaatg 900
gcatagaagt cagtattgaa tgtattaaat tggctttctt cttcaggaaa aactagacca 960
gacctctgtt atcttctgtg aaatcatcct acaagcaaac taacctggaa tcccttcacc 1020
tagagataat gtacaagcct tagaactcct cattctcatg ttgctattta tgtacctaat 1080
taaaacccaa gttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 1124
<210> 47
<211> 2967
<212> DNA
<213> Homo sapiens
<400> 47
agtgcggacg tcgccattcc tggcccatgg gaagattgcg tttcacctgc tcctgaaggc 60
cgaaggtggc tctagcgcat cctttgtcgc gccgtgacct gcaggtactg acagatccgt 120
agggaggaca ccgtgacttc ccggacgctg ggaaatggac tcagtctcct ttgaggatgt 180
ggccgtgaac ttcaccctgg aggagtgggc tttgctggat tcttcacaga aaaagctcta 240
tgaagatgtg atgcaggaga ccttcaaaaa cctggtttgt ctaggaaaaa agtgggaaga 300
ccaggacatt gaagatgacc acagaaacca ggggaaaaat cgaagatgtc atatggttga 360
gagactctgt gaaagtagaa gaggtagcaa atgtggagaa accactagcc agatgccaaa 420
tgttaatatc aacaaggaaa cttttactgg agcaaaacca catgaatgca gcttttgtgg 480
aagagacttc attcatcatt cgtcccttaa taggcacatg agatctcaca ctggacagaa 540
accaaatgag tatcaggaat atgaaaagca accatgtaaa tgtaaagcag ttgggaaaac 600
cttcagttat caccactgct ttcgcaaaca tgaaagaact cacactggag tgaagcccta 660
tgaatgtaaa cagtgtggga aagcctttat atattaccag ccatttcaaa gacatgaaag 720
gactcatgct ggacagaaac cctatgaatg taagcaatgt ggaaaaacct ttatatatta 780
ccagtctttt caaaaacatg ctcatactgg aaagaaaccc tatgaatgta aacagtgtgg 840
gaaagccttt atatgttacc aatcttttca aagacacaaa aggactcaca ctggagagaa 900
accctatgaa tgtaagcaat gtggtaaggc tttcagttgt cccacatact ttcgaactca 960
tgaaagaact cacactggag aaaaacccta caaatgtaaa gaatgtggta aagccttcag 1020
ttttctcagt tcttttcgaa ggcataaaag gactcatagt ggagagaaac cctatgaatg 1080
taaagaatgt ggaaaagcct tcttttattc tgcaagcttt cgagcacatg taataataca 1140
cactggggct cgaccttata aatgtaaaga atgtgggaaa gccttcaact cttctaattc 1200
ctgtcgagtg catgaaagaa ctcatattgg agaaaaacca tatgaatgta aacgatgtgg 1260
caaatcattc agttggtcca tttctcttcg attgcatgaa agaactcata ctggagagaa 1320
accttatgag tgtaaacagt gtcataaaac cttcagtttt tcaagttccc ttcgagaaca 1380
cgaaacaact cacactggag agaaacccta tgaatgtaaa caatgtggta aaaccttcag 1440
tttttcaagt tcccttcaaa gacatgaaag gactcacaat gcagagaaac cctatgaatg 1500
taaacagtgt gggaaagcct tcaggtgttc aagttatttt cgaattcatg aaaggtcaca 1560
cactggagag aaaccctatg aatgtaaaca gtgtggaaaa gttttcattc gttccagttc 1620
ctttcgactg catgaaagaa cacacactgg agagaaaccc tatgaatgta aactatgcgg 1680
taaaaccttc agtttttcaa gttcccttcg agaacatgaa aaaattcaca ctggaaataa 1740
gccttttgag tgtaagcaat gtggtaaggc cttccttcgt tccagtcaaa ttcgattgca 1800
tgaaaggact cacactggag agaaaccgta tcaatgtaaa caatgtggaa aagccttcat 1860
ttcttccagt aaatttcgaa tgcatgagag aactcacacg ggagagaaac cctatcgatg 1920
taaacaatgt gggaaagcct tcagattttc aagttctgtt cgaattcatg aaaggtctca 1980
cactggagag aaaccttatg aatgcaaaca atgtggaaaa gccttcattt cttccagtca 2040
ctttcgactg catgaaagga ctcatatggg agagaaagtc taagaatata agcaacattc 2100
tgaagccttc ggttgttcca gctccttctg aatacacaaa agagttcata ctggacagaa 2160
gctgtgtgaa tacaaacatt gttctaaagc ccttaattgt tccagtttct tttgagcacg 2220
aaagaattcc cactggtgag aaacagtatg aatgtaaaca ttgtgattaa gccttcagtt 2280
gacctaattc atttcaaaga caggactcgt gctgcagtga aatctgtttt gttttttgtt 2340
ttttgttttt ttaaaaaagg ccaagcttgt tggctcatgc ctatagtccc agcactttgg 2400
gaggccaagg tgcaaggcag gcagatcatt tgaggtcaga aattcgagac cagcgtggtc 2460
aacatggtgt aaccccatct ctactaaaaa ttaccaaaaa atgaaccagg catggtagtg 2520
catgcctcta atcccagcta ctcaggaggc taaggcagga gaatcacttg aacctggaga 2580
cagaggttgc agtgagctga gatcacgcca ctgcattcca gcctgtgcga cagaatgaga 2640
cactgtctca agaaaaaata aaagtgggaa aatcttccaa ctgtcctcta gagtgtgaat 2700
atatgaaagg agtcagagtg gggtgaaagt ctataaatgt aagacatttg ggaaagcctt 2760
cacacagcct tttgagcaca catgagaatg tatactggag agaaacccta taaatattaa 2820
gaatgtggga aattcttcat cctagttctt ttgttgttgt tgatgataca aaaatatttt 2880
catttaataa agattgtcag gttatattta ataagaaaga aagtatcatg taaacagccc 2940
agtaataaaa ttttacaatc ttaaaaa 2967
<210> 48
<211> 1725
<212> DNA
<213> Homo sapiens
<400> 48
acgtccgggg aggggccagg tgagcggcag acccggcacg caggtggggg ccggcggggt 60
ccgtggccag agctgcagag agacaaggcg gcggcggctg ctgtgctggg tgcagtgagg 120
aagaggccct cggtggtgcc catggctggc caggatcctg cgctgagcac gagtcacccg 180
ttctacgacg tggccagaca tggcattctg caggtggcag gggatgaccg ctttggaaga 240
cgtgttgtca cgttcagctg ctgccggatg ccaccctccc acgagctgga ccaccagcgg 300
ctgctggagt atttgaagta cacactggac caatacgttg agaacgatta taccatcgtc 360
tatttccact acgggctgaa cagccggaac aagccttccc tgggctggct ccagagcgca 420
tacaaggagt tcgataggaa agacggggat ctcactatgt ggcccaggct ggtctcgaac 480
tccaagctca agcgatcctc ccacctcagc ctcccaaagt actgggatta caggtacaag 540
aagaacttga aggccctcta cgtggtgcac cccaccagct tcatcaaggt cctgtggaac 600
atcttgaagc ccctcatcag tcacaagttt gggaagaaag tcatctattt caactacctg 660
agtgagctcc acgaacacct taaatacgac cagctggtca tccctcccga agttttgcgg 720
tacgatgaga agctccagag cctgcacgag ggccggacgc cgcctcccac caagacacca 780
ccgccgcggc ccccgctgcc cacacagcag tttggcgtca gtctgcaata cctcaaagac 840
aaaaatcaag gcgaactcat cccccctgtg ctgaggttca cagtgacgta cctgagagag 900
aaaggcctgc gcaccgaggg cctgttccgg agatccgcca gcgtgcagac cgtccgcgag 960
atccagaggc tctacaacca agggaagccc gtgaactttg acgactacgg ggacattcac 1020
atccctgccg tgatcctgaa gaccttcctg cgagagctgc cccagccgct tctgaccttc 1080
caggcctacg agcagattct cgggatcacc tgtgtggaga gcagcctgcg tgtcactggc 1140
tgccgccaga tcttacggag cctcccagag cacaactacg tcgtcctccg ctacctcatg 1200
ggcttcctgc atgcggtgtc ccgggagagc atcttcaaca aaatgaacag ctctaacctg 1260
gcctgtgtct tcgggctgaa tttgatctgg ccatcccagg gggtctcctc cctgagtgcc 1320
cttgtgcccc tgaacatgtt cactgaactg ctgatcgagt actatgaaaa gatcttcagc 1380
accccggagg cacctgggga gcacggcctg gcaccatggg aacaggggag cagggcagcc 1440
cctttgcagg aggctgtgcc acggacacaa gccacgggcc tcaccaagcc taccctacct 1500
ccgagtcccc tgatggcagc cagaagacgt ctctagtgtt gcgaacactc tgtatatttc 1560
gagctacctc ccacacctgt ctgtgcactt gtatgttttg taaacttggc atctgtaaaa 1620
ataaccagcc attagatgaa ttcagaacct tctaatgaaa actccatgcc tctggtcctt 1680
ggactcttgt ccatggttcc tgagctgtgg accgggatag aataa 1725
<210> 49
<211> 1632
<212> DNA
<213> Homo sapiens
<400> 49
acgtccgggg aggggccagg tgagcggcag acccggcacg caggtggggg ccggcggggt 60
ccgtggccag agctgcagag agacaaggcg gcggcggctg ctgtgctggg tgcagtgagg 120
aagaggccct cggtggtgcc catggctggc caggatcctg cgctgagcac gagtcacccg 180
ttctacgacg tggccagaca tggcattctg caggtggcag gggatgaccg ctttggaaga 240
cgtgttgtca cgttcagctg ctgccggatg ccaccctccc acgagctgga ccaccagcgg 300
ctgctggagt atttgaagta cacactggac caatacgttg agaacgatta taccatcgtc 360
tatttccact acgggctgaa cagccggaac aagccttccc tgggctggct ccagagcgca 420
tacaaggagt tcgataggaa gtacaagaag aacttgaagg ccctctacgt ggtgcacccc 480
accagcttca tcaaggtcct gtggaacatc ttgaagcccc tcatcagtca caagtttggg 540
aagaaagtca tctatttcaa ctacctgagt gagctccacg aacaccttaa atacgaccag 600
ctggtcatcc ctcccgaagt tttgcggtac gatgagaagc tccagagcct gcacgagggc 660
cggacgccgc ctcccaccaa gacaccaccg ccgcggcccc cgctgcccac acagcagttt 720
ggcgtcagtc tgcaatacct caaagacaaa aatcaaggcg aactcatccc ccctgtgctg 780
aggttcacag tgacgtacct gagagagaaa ggcctgcgca ccgagggcct gttccggaga 840
tccgccagcg tgcagaccgt ccgcgagatc cagaggctct acaaccaagg gaagcccgtg 900
aactttgacg actacgggga cattcacatc cctgccgtga tcctgaagac cttcctgcga 960
gagctgcccc agccgcttct gaccttccag gcctacgagc agattctcgg gatcacctgt 1020
gtggagagca gcctgcgtgt cactggctgc cgccagatct tacggagcct cccagagcac 1080
aactacgtcg tcctccgcta cctcatgggc ttcctgcatg cggtgtcccg ggagagcatc 1140
ttcaacaaaa tgaacagctc taacctggcc tgtgtcttcg ggctgaattt gatctggcca 1200
tcccaggggg tctcctccct gagtgccctt gtgcccctga acatgttcac tgaactgctg 1260
atcgagtact atgaaaagat cttcagcacc ccggaggcac ctggggagca cggcctggca 1320
ccatgggaac aggggagcag ggcagcccct ttgcaggagg ctgtgccacg gacacaagcc 1380
acgggcctca ccaagcctac cctacctccg agtcccctga tggcagccag aagacgtctc 1440
tagtgttgcg aacactctgt atatttcgag ctacctccca cacctgtctg tgcacttgta 1500
tgttttgtaa acttggcatc tgtaaaaata accagccatt agatgaattc agaaccttct 1560
aatgaaaact ccatgcctct ggtccttgga ctcttgtcca tggttcctga gctgtggacc 1620
gggatagaat aa 1632
<210> 50
<211> 11389
<212> DNA
<213> Homo sapiens
<400> 50
atggcgccgc cgccgccgcc cgtgctgccc gtgctgctgc tcctggccgc cgccgccgcc 60
ctgccggcga tggggctgcg agcggccgcc tgggagccgc gcgtacccgg cgggacccgc 120
gccttcgccc tccggcccgg ctgtacctac gcggtgggcg ccgcttgcac gccccgggcg 180
ccgcgggagc tgctggacgt gggccgcgat gggcggctgg caggacgtcg gcgcgtctcg 240
ggcgcggggc gcccgctgcc gctgcaagtc cgcttggtgg cccgcagtgc cccgacggcg 300
ctgagccgcc gcctgcgggc gcgcacgcac cttcccggct gcggagcccg tgcccggctc 360
tgcggaaccg gtgcccggct ctgcggggcg ctctgcttcc ccgtccccgg cggctgcgcg 420
gccgcgcagc attcggcgct cgcagctccg accaccttac ccgcctgccg ctgcccgccg 480
cgccccaggc cccgctgtcc cggccgtccc atctgcctgc cgccgggcgg ctcggtccgc 540
ctgcgtctgc tgtgcgccct gcggcgcgcg gctggcgccg tccgggtggg actggcgctg 600
gaggccgcca ccgcggggac gccctccgcg tcgccatccc catcgccgcc cctgccgccg 660
aacttgcccg aagcccgggc ggggccggcg cgacgggccc ggcggggcac gagcggcaga 720
gggagcctga agtttccgat gcccaactac caggtggcgt tgtttgagaa cgaaccggcg 780
ggcaccctca tcctccagct gcacgcgcac tacaccatcg agggcgagga ggagcgcgtg 840
agctattaca tggaggggct gttcgacgag cgctcccggg gctacttccg aatcgactct 900
gccacgggcg ccgtgagcac ggacagcgta ctggaccgcg agaccaagga gacgcacgtc 960
ctcagggtga aagccgtgga ctacagtacg ccgccgcgct cggccaccac ctacatcact 1020
gtcttggtca aagacaccaa cgaccacagc ccggtcttcg agcagtcgga gtaccgcgag 1080
cgcgtgcggg agaacctgga ggtgggctac gaggtgctga ccatccgcgc cagcgaccgc 1140
gactcgccca tcaacgccaa cttgcgttac cgcgtgttgg ggggcgcgtg ggacgtcttc 1200
cagctcaacg agagctctgg cgtggtgagc acacgggcgg tgctggaccg ggaggaggcg 1260
gccgagtacc agctcctggt ggaggccaac gaccaggggc gcaatccggg cccgctcagt 1320
gccacggcca ccgtgtacat cgaggtggag gacgagaacg acaactaccc ccagttcagc 1380
gagcagaact acgtggtcca ggtgcccgag gacgtggggc tcaacacggc tgtgctgcga 1440
gtgcaggcca cggaccggga ccagggccag aacgcggcca ttcactacag catcctcagc 1500
gggaacgtgg ccggccagtt ctacctgcac tcgctgagcg ggatcctgga tgtgatcaac 1560
cccttggatt tcgaggatgt ccagaaatac tcgctgagca ttaaggccca ggatgggggc 1620
cggcccccgc tcatcaattc ttcaggggtg gtgtctgtgc aggtgctgga tgtcaacgac 1680
aacgagccta tctttgtgag cagccccttc caggccacgg tgctggagaa tgtgcccctg 1740
ggctaccccg tggtgcacat tcaggcggtg gacgcggact ctggagagaa cgcccggctg 1800
cactatcgcc tggtggacac ggcctccacc tttctggggg gcggcagcgc tgggcctaag 1860
aatcctgccc ccacccctga cttccccttc cagatccaca acagctccgg ttggatcaca 1920
gtgtgtgccg agctggaccg cgaggaggtg gagcactaca gcttcggggt ggaggcggtg 1980
gaccacggct cgccccccat gagctcctcc accagcgtgt ccatcacggt gctggacgtg 2040
aatgacaacg acccggtgtt cacgcagccc acctacgagc ttcgtctgaa tgaggatgcg 2100
gccgtgggga gcagcgtgct gaccctgcag gcccgcgacc gtgacgccaa cagtgtgatt 2160
acctaccagc tcacaggcgg caacacccgg aaccgctttg cactcagcag ccagagaggg 2220
ggcggcctca tcaccctggc gctacctctg gactacaagc aggagcagca gtacgtgctg 2280
gcggtgacag catccgacgg cacacggtcg cacactgcgc atgtcctaat caacgtcact 2340
gatgccaaca cccacaggcc tgtctttcag agctcccatt acacagtgag tgtcagtgag 2400
gacaggcctg tgggcacctc cattgctacc ctcagtgcca acgatgagga cacaggagag 2460
aatgcccgca tcacctacgt gattcaggac cccgtgccgc agttccgcat tgaccccgac 2520
agtggcacca tgtacaccat gatggagctg gactatgaga accaggtcgc ctacacgctg 2580
accatcatgg cccaggacaa cggcatcccg cagaaatcag acaccaccac cctagagatc 2640
ctcatcctcg atgccaatga caatgcaccc cagttcctgt gggatttcta ccagggttcc 2700
atctttgagg atgctccacc ctcgaccagc atcctccagg tctctgccac ggaccgggac 2760
tcaggtccca atgggcgtct gctgtacacc ttccagggtg gggacgacgg cgatggggac 2820
ttctacatcg agcccacgtc cggtgtgatt cgcacccagc gccggctgga ccgggagaat 2880
gtggccgtgt acaacctttg ggctctggct gtggatcggg gcagtcccac tccccttagc 2940
gcctcggtag aaatccaggt gaccatcttg gacattaatg acaatgcccc catgtttgag 3000
aaggacgaac tggagctgtt tgttgaggag aacaacccag tggggtcggt ggtggcaaag 3060
attcgtgcta acgaccctga tgaaggccct aatgcccaga tcatgtatca gattgtggaa 3120
ggggacatgc ggcatttctt ccagctggac ctgctcaacg gggacctgcg tgccatggtg 3180
gagctggact ttgaggtccg gcgggagtat gtgctggtgg tgcaggccac gtcggctccg 3240
ctggtgagcc gagccacggt gcacatcctt ctcgtggacc agaatgacaa cccgcctgtg 3300
ctgcccgact tccagatcct cttcaacaac tatgtcacca acaagtccaa cagtttcccc 3360
accggcgtga tcggctgcat cccggcccat gaccccgacg tgtcagacag cctcaactac 3420
accttcgtgc agggcaacga gctgcgcctg ttgctgctgg accccgccac gggcgaactg 3480
cagctcagcc gcgacctgga caacaaccgg ccgctggagg cgctcatgga ggtgtctgtg 3540
tctgatggca tccacagcgt cacggccttc tgcaccctgc gtgtcaccat catcacggac 3600
gacatgctga ccaacagcat cactgtccgc ctggagaaca tgtcccagga gaagttcctg 3660
tccccgctgc tggccctctt cgtggagggg gtggccgccg tgctgtccac caccaaggac 3720
gacgtcttcg tcttcaacgt ccagaacgac accgacgtca gctccaacat cctgaacgtg 3780
accttctcgg cgctgctgcc tggcggcgtc cgcggccagt tcttcccgtc ggaggacctg 3840
caggagcaga tctacctgaa tcggacgctg ctgaccacca tctccacgca gcgcgtgctg 3900
cccttcgacg acaacatctg cctgcgcgag ccctgcgaga actacatgaa gtgcgtgtcc 3960
gttctgcgat tcgacagctc cgcgcccttc ctcagctcca ccaccgtgct cttccggccc 4020
atccacccca tcaacggcct gcgctgccgc tgcccgcccg gcttcaccgg cgactactgc 4080
gagacggaga tcgacctctg ctactccgac ccgtgcggcg ccaacggccg ctgccgcagc 4140
cgcgagggcg gctacacctg cgagtgcttc gaggacttca ctggagagca ctgtgaggtg 4200
gatgcccgct caggccgctg tgccaacggg gtgtgcaaga acgggggcac ctgcgtgaac 4260
ctgctcatcg gcggcttcca ctgcgtgtgt cctcctggcg agtatgagag gccctactgt 4320
gaggtgacca ccaggagctt cccgccccag tccttcgtca ccttccgggg cctgagacag 4380
cgcttccact tcaccatctc cctcacgttt gccactcagg aaaggaacgg cttgcttctc 4440
tacaacggcc gcttcaatga gaagcacgac ttcatcgccc tggagatcgt ggacgagcag 4500
gtgcagctca ccttctctgc aggcgagaca acaacgaccg tggcaccgaa ggttcccagt 4560
ggtgtgagtg acgggcggtg gcactctgtg caggtgcagt actacaacaa gcccaatatt 4620
ggccacctgg gcctgcccca tgggccgtcc ggggaaaaga tggccgtggt gacagtggat 4680
gattgtgaca caaccatggc tgtgcgcttt ggaaaggaca tcgggaacta cagctgcgct 4740
gcccagggca ctcagaccgg ctccaagaag tccctggatc tgaccggccc tctactcctg 4800
gggggtgtcc ccaacctgcc agaagacttc ccagtgcaca accggcagtt cgtgggctgc 4860
atgcggaacc tgtcagtcga cggcaaaaat gtggacatgg ccggattcat cgccaacaat 4920
ggcacccggg aaggctgcgc tgctcggagg aacttctgcg atgggaggcg gtgtcagaat 4980
ggaggcacct gtgtcaacag gtggaatatg tatctgtgtg agtgtccact ccgattcggc 5040
gggaagaact gtgagcaagc catgcctcac ccccagctct tcagcggtga gagcgtcgtg 5100
tcctggagtg acctgaacat catcatctct gtgccctggt acctggggct catgttccgg 5160
acccggaagg aggacagcgt tctgatggag gccaccagtg gtgggcccac cagctttcgc 5220
ctccagatcc tgaacaacta cctccagttt gaggtgtccc acggcccctc cgatgtggag 5280
tccgtgatgc tgtccgggtt gcgggtgacc gacggggagt ggcaccacct gctgatcgag 5340
ctgaagaatg ttaaggagga cagtgagatg aagcacctgg tcaccatgac cttggactat 5400
gggatggacc agaacaaggc agatatcggg ggcatgcttc ccgggctgac ggtaaggagc 5460
gtggtggtcg gaggcgcctc tgaagacaag gtctccgtgc gccgtggatt ccgaggctgc 5520
atgcagggag tgaggatggg ggggacgccc accaacgtcg ccaccctgaa catgaacaac 5580
gcactcaagg tcagggtgaa ggacggctgt gatgtggacg acccctgtac ctcgagcccc 5640
tgtcccccca atagccgctg ccacgacgcc tgggaggact acagctgcgt ctgtgacaaa 5700
gggtaccttg gaataaactg tgtggatgcc tgtcacctga acccctgcga gaacatgggg 5760
gcctgcgtgc gctcccccgg ctccccgcag ggctacgtgt gcgagtgtgg gcccagtcac 5820
tacgggccgt actgtgagaa caaactcgac cttccgtgcc ccagaggctg gtgggggaac 5880
cccgtctgtg gaccctgcca ctgtgccgtc agcaaaggct ttgatcccga ctgtaataag 5940
accaacggcc agtgccaatg caaggagaat tactacaagc tcctagccca ggacacctgt 6000
ctgccctgcg actgcttccc ccatggctcc cacagccgca cttgcgacat ggccaccggg 6060
cagtgtgcct gcaagcccgg cgtcatcggc cgccagtgca accgctgcga caacccgttt 6120
gccgaggtca ccacgctcgg ctgtgaagtg atctacaatg gctgtcccaa agcatttgag 6180
gccggcatct ggtggccaca gaccaagttc gggcagccgg ctgcggtgcc atgccctaag 6240
ggatccgttg gaaatgcggt ccgacactgc agcggggaga agggctggct gcccccagag 6300
ctctttaact gtaccaccat ctccttcgtg gacctcaggg ccatgaatga gaagctgagc 6360
cgcaatgaga cgcaggtgga cggcgccagg gccctgcagc tggtgagggc gctgcgcagt 6420
gctacacagc acacgggcac gctctttggc aatgacgtgc gcacggccta ccagctgctg 6480
ggccacgtcc ttcagcacga gagctggcag cagggcttcg acctggcagc cacgcaggac 6540
gccgactttc acgaggacgt catccactcg ggcagcgccc tcctggcccc agccaccagg 6600
gcggcgtggg agcagatcca gcggagcgag ggcggcacgg cacagctgct ccggcgcctc 6660
gagggctact tcagcaacgt ggcacgcaac gtgcggcgga cgtacctgcg gcccttcgtc 6720
atcgtcaccg ccaacatgat tcttgctgtc gacatctttg acaagttcaa ctttacggga 6780
gccagggtcc cgcgattcga caccatccat gaagagttcc ccagggagct ggagtcctcc 6840
gtctccttcc cagccgactt cttcagacca cctgaagaaa aagaaggccc cctgctgagg 6900
ccggctggcc ggaggaccac cccgcagacc acgcgcccgg ggcctggcac cgagagggag 6960
gccccgatca gcaggcggag gcgacaccct gatgacgctg gccagttcgc cgtcgctctg 7020
gtcatcattt accgcaccct ggggcagctc ctgcccgagc gctacgaccc cgaccgtcgc 7080
agcctccggt tgcctcaccg gcccatcatt aataccccga tggtgagcac gctggtgtac 7140
agcgaggggg ctccgctccc gagacccctg gagaggcccg tcctggtgga gttcgccctg 7200
ctggaggtgg aggagcgaac caagcctgtc tgcgtgttct ggaaccactc cctggccgtt 7260
ggtgggacgg gagggtggtc tgcccggggc tgcgagctcc tgtccaggaa ccggacacat 7320
gtcgcctgcc agtgcagcca cacagccagc tttgcggtgc tcatggatat ctccaggcgt 7380
gagaacgggg aggtcctgcc tctgaagatt gtcacctatg ccgctgtgtc cttgtcactg 7440
gcagccctgc tggtggcctt cgtcctcctg agcctggtcc gcatgctgcg ctccaacctg 7500
cacagcattc acaagcacct cgccgtggcg ctcttcctct ctcagctggt gttcgtgatt 7560
gggatcaacc agacggaaaa cccgtttctg tgcacagtgg ttgccatcct cctccactac 7620
atctacatga gcacctttgc ctggaccctc gtggagagcc tgcatgtcta ccgcatgctg 7680
accgaggtgc gcaacatcga cacggggccc atgcggttct actacgtcgt gggctggggc 7740
atcccggcca ttgtcacagg actggcggtc ggcctggacc cccagggcta cgggaacccc 7800
gacttctgct ggctgtcgct tcaagacacc ctgatttgga gctttgcggg gcccatcgga 7860
gctgttataa tcatcaacac agtcacttct gtcctatctg caaaggtttc ctgccaaaga 7920
aagcaccatt attatgggaa aaaagggatc gtctccctgc tgaggaccgc attcctcctg 7980
ctgctgctca tcagcgccac ctggctgctg gggctgctgg ctgtgaaccg cgatgcactg 8040
agctttcact acctcttcgc catcttcagc ggcttacagg gccccttcgt cctccttttc 8100
cactgcgtgc tcaaccagga ggtccggaag cacctgaagg gcgtgctcgg cgggaggaag 8160
ctgcacctgg aggactccgc caccaccagg gccaccctgc tgacgcgctc cctcaactgc 8220
aacaccacct tcggtgacgg gcctgacatg ctgcgcacag acttgggcga gtccaccgcc 8280
tcgctggaca gcatcgtcag ggatgaaggg atccagaagc tcggcgtgtc ctctgggctg 8340
gtgaggggca gccacggaga gccagacgcg tccctcatgc ccaggagctg caaggatccc 8400
cctggccacg attccgactc agatagcgag ctgtccctgg atgagcagag cagctcttac 8460
gcctcctcac actcgtcaga cagcgaggac gatggggtgg gagctgagga aaaatgggac 8520
ccggccaggg gcgccgtcca cagcaccccc aaaggggacg ctgtggccaa ccacgttccg 8580
gccggctggc ccgaccagag cctggctgag agtgacagtg aggaccccag cggcaagccc 8640
cgcctgaagg tggagaccaa ggtcagcgtg gagctgcacc gcgaggagca gggcagtcac 8700
cgtggagagt accccccgga ccaggagagc gggggcgcag ccaggcttgc tagcagccag 8760
cccccagagc agaggaaagg catcttgaaa aataaagtca cctacccgcc gccgctgacg 8820
ctgacggagc agacgctgaa gggccggctc cgggagaagc tggccgactg tgagcagagc 8880
cccacatcct cgcgcacgtc ttccctgggc tctggcggcc ccgactgcgc catcacagtc 8940
aagagccctg ggagggagcc ggggcgtgac cacctcaacg gggtggccat gaatgtgcgc 9000
actgggagcg cccaggccga tggctccgac tctgagaaac cgtgaggcaa gcccgtcacc 9060
ccacacaggc tgcggcatca ccctcagacc ttggagccca aggggccact gcccttgaag 9120
tggagtgggc ccagagtgtg gcggtcccca tggtggcagc cccccgactg atcatccaga 9180
cacaaaggtc ttggttctcc caggagctca gggcctgtca gacctggtga caagtgccaa 9240
aggccacagg catgagggag gcgtggacca ctgggccagc accgctgagt cctaagactg 9300
cagtcaaagc cagaactgag aggggacccc agactgggcc cagaggctgg ccagagttca 9360
ggaacgccgg gcacagacca aagaccgcgg tccagccccg cccaggcggg catctcatgg 9420
cagtgcggac ccgtggctgg cagcccgggc agtcctttgc aaaggcaccc cttgtcttaa 9480
aatcacttcg ctatgtggga aaggtggaga tacttttata tatttgtatg ggactctgag 9540
gaggtgcaac ctgtatatat attgcattcg tgctgacttt gttatcccga gagatccatg 9600
caatgatctc ttgctgtctt ctctgtcaag attgcacagt tgtacttgaa tctggcatgt 9660
gttgacgaaa ctggtgcccc agcagatcaa aggtgggaaa tacgtcagca gtggggctaa 9720
aaccaagcgg ctagaagccc tacagctgcc ttcggccagg aagtgaggat ggtgtgggcc 9780
ctccccgccg gccccctggg tccccagtgt tcgctgtgtg tgcgtttgtc ctctgctgcc 9840
atctgccccg gctgtgtgaa ttcaagacag ggcagtgcag cactaggcag gtgtgaggag 9900
ccctgctgag gtcactgtgg ggcacggttg ccacacggct gtcatttttc acctggtcat 9960
tctgtgacca ccaccccctc ccctcaccgc ctcccaggtg gcccgggagc tgcaggtggg 10020
gatggctttg tcctttgctc ctgctccccg tgggacctgg gaccttaaag cgttgcaggt 10080
tcctgatttg gacagaggtg tggggccttc caggccgtta catacctcct gccaattctc 10140
taactctctg agactgcgag gatctccagg cagggttctc ccctctggag tctgaccaat 10200
tacttcattt tgcttcaaat ggccaattgt gcagagggac aaagccacag ccacactctt 10260
caacggttac caaactgttt ttggaaattc acaccaaggt cgggcccact gcaggcagct 10320
ggcacagcgt ggcccgaggg gctgtggaac gggtcccgga actgtcagac atgtttgatt 10380
ttagcgtttc ctttgttctt caaatcaggt gcccaaataa gtgatcagca cagctgcttc 10440
caaataggag aaaccataaa ataggatgaa aatcaagtaa aatgcaaaga tgtccacact 10500
gttttaaact tgaccctgat gaaaatgtga gcactgttag cagatgccta tgggagagga 10560
aaagcgtatc tgaaaatggt ccaggacagg aggatgaaat gagatcccag agtcctcaca 10620
cctgaatgaa ttatacatgt gccttaccag gtgagtggtc tttcgaagat aaaaaactct 10680
agtcccttta aacgtttgcc cctggcgttt cctaagtacg aaaaggtttt taagtcttcg 10740
aacagtctcc tttcatgact ttaacaggat tctgccccct gaggtgtaat ttttttgttc 10800
tatttttttc cacgtactcc acagccaaca tcacgaggtg taatttttaa tttgatcaga 10860
actgttacca aaaaacaact gtcagtttta ttgagatggg aaaaatgtaa acctattttt 10920
attacttaag actttatggg agagattaga cactggaggt ttttaacaga acgtgtattt 10980
attaatgttc aaaacactgg aattacaaat gagaagagtc tacaataaat taagattttt 11040
gaatttgtac ttctgcggtg ctggtttttc tccacaaaca cccccgcccc tccccatgcc 11100
cagggtggcc gtggaaggga cggtttacgg acgtgcagct gagctgtccg tgtcccatgc 11160
tccctcagcc agtggaacgt gccggaactt tttgtccatt ccctagtagg cctgccacag 11220
cctagatggg cagtttttgt ctttcaccaa atttgaggac tttttttttt tgccattatt 11280
tcttcagttt tcttttcttg cactgatctt tctcctctcc ttctgtgact ccagtgactc 11340
agacgttaga cctcttgatg ttttcccact ggtccctgag gctctgttc 11389
<210> 51
<211> 2112
<212> DNA
<213> Homo sapiens
<400> 51
tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60
aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120
agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct taccaatgat 180
gcgagctcag agtcaatagc atccttctct aaacaggagg tcatgagtag ctttctgcca 240
gagggagggt gttacgagct gctcactgtg ataggcaaag gatttgagga cctgatgact 300
gtgaatctag caaggtacaa accaacagga gagtacgtga ctgtacggag gattaaccta 360
gaagcttgtt ccaatgagat ggtaacattc ttgcagggcg agctgcatgt ctccaaactc 420
ttcaaccatc ccaatatcgt gccatatcga gccactttta ttgcagacaa tgagctgtgg 480
gttgtcacat cattcatggc atacggttct gcaaaagatc tcatctgtac acacttcatg 540
gatggcatga atgagctggc gattgcttac atcctgcagg gggtgctgaa ggccctcgac 600
tacatccacc acatgggata tgtacacagg agtgtcaaag ccagccacat cctgatctct 660
gtggatggga aggtctacct gtctggtttg cgcagcaacc tcagcatgat aagccatggg 720
cagcggcagc gagtggtcca cgattttccc aagtacagtg tcaaggttct gccgtggctc 780
agccccgagg tcctccagca gaatctccag ggttatgatg ccaagtctga catctacagt 840
gtgggaatca cagcctgtga actggccaac ggccatgtcc cctttaagga tatgcctgcc 900
acccagatgc tgctagagaa actgaacggc acagtgccct gcctgttgga taccagcacc 960
atccccgctg aggagctgac catgagccct tcgcgctcag tggccaactc tggcctgagt 1020
gacagcctga ccaccagcac cccccggccc tccaacggtg actcgccctc ccacccctac 1080
caccgaacct tctcccccca cttccaccac tttgtggagc agtgccttca gcgcaacccg 1140
gatgccaggc ccagtgccag caccctcctg aaccactctt tcttcaagca gatcaagcga 1200
cgtgcctcag aggctttgcc cgaattgctt cgtcctgtca cccccatcac caattttgag 1260
ggcagccagt ctcaggacca cagtggaatc tttggcctgg taacaaacct ggaagagctg 1320
gaggtggacg attgggagtt ctgagcctct gcaaactgtg cgcattctcc agccagggat 1380
gcagaggcca cccagaggcc cttcctgagg gccggccaca ttcccgccct cctgggcaga 1440
ttgggtagaa aggacattct tccaggaaag ttgactgctg actgattggg aaagaaaatc 1500
ctggagagac acttcactgc tccaaggctt ttgagacaca agggaatctc aacaaccagg 1560
gatcaggagg gtccaaagcc gacattccca gtcctgtgag ctcaggtgac ctcctccgca 1620
gaagagagat gctgctctgg ccctgggagc tgaattccaa gcccagggtt tggctcctta 1680
aacccgagga ccgccacctc ttcccagtgc ttgcgaccag cctcattcta tttaactttg 1740
ctctcagatg cctcagatgc tataggtcag tgaaagggca agtagtaagc tgcctgcctc 1800
ccttccctca gacctctccc tcataattcc agagaagggc atttctgtct ttttaagcac 1860
agactaaggc tggaacagtc catccttatc cctcttctgg cttgggccct gacacctaag 1920
tctttcccac ggtttatgtg tgtgcctcat tcctttccca ccaagaatcc atcttagcgc 1980
ctcctgccag ctgccctggt gctttctcca agggccatca gtgtcttgcc tagcttgagg 2040
gcttaagtcc ttatgctgtg ttagtttcgt tgtcagaaca aattaaaatt ttcagagacg 2100
ctgctggaaa aa 2112
<210> 52
<211> 2223
<212> DNA
<213> Homo sapiens
<400> 52
tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60
aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120
agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct tgtaagtaaa 180
ccagagcgaa tcaggcggtg ggtctcggaa aagttcattg ttgagggctt aagagatttg 240
gaactatttg gagagcagcc tccgggtgac actcggagaa aaaccaatga tgcgagctca 300
gagtcaatag catccttctc taaacaggag gtcatgagta gctttctgcc agagggaggg 360
tgttacgagc tgctcactgt gataggcaaa ggatttgagg acctgatgac tgtgaatcta 420
gcaaggtaca aaccaacagg agagtacgtg actgtacgga ggattaacct agaagcttgt 480
tccaatgaga tggtaacatt cttgcagggc gagctgcatg tctccaaact cttcaaccat 540
cccaatatcg tgccatatcg agccactttt attgcagaca atgagctgtg ggttgtcaca 600
tcattcatgg catacggttc tgcaaaagat ctcatctgta cacacttcat ggatggcatg 660
aatgagctgg cgattgctta catcctgcag ggggtgctga aggccctcga ctacatccac 720
cacatgggat atgtacacag gagtgtcaaa gccagccaca tcctgatctc tgtggatggg 780
aaggtctacc tgtctggttt gcgcagcaac ctcagcatga taagccatgg gcagcggcag 840
cgagtggtcc acgattttcc caagtacagt gtcaaggttc tgccgtggct cagccccgag 900
gtcctccagc agaatctcca gggttatgat gccaagtctg acatctacag tgtgggaatc 960
acagcctgtg aactggccaa cggccatgtc ccctttaagg atatgcctgc cacccagatg 1020
ctgctagaga aactgaacgg cacagtgccc tgcctgttgg ataccagcac catccccgct 1080
gaggagctga ccatgagccc ttcgcgctca gtggccaact ctggcctgag tgacagcctg 1140
accaccagca ccccccggcc ctccaacggt gactcgccct cccaccccta ccaccgaacc 1200
ttctcccccc acttccacca ctttgtggag cagtgccttc agcgcaaccc ggatgccagg 1260
cccagtgcca gcaccctcct gaaccactct ttcttcaagc agatcaagcg acgtgcctca 1320
gaggctttgc ccgaattgct tcgtcctgtc acccccatca ccaattttga gggcagccag 1380
tctcaggacc acagtggaat ctttggcctg gtaacaaacc tggaagagct ggaggtggac 1440
gattgggagt tctgagcctc tgcaaactgt gcgcattctc cagccaggga tgcagaggcc 1500
acccagaggc ccttcctgag ggccggccac attcccgccc tcctgggcag attgggtaga 1560
aaggacattc ttccaggaaa gttgactgct gactgattgg gaaagaaaat cctggagaga 1620
cacttcactg ctccaaggct tttgagacac aagggaatct caacaaccag ggatcaggag 1680
ggtccaaagc cgacattccc agtcctgtga gctcaggtga cctcctccgc agaagagaga 1740
tgctgctctg gccctgggag ctgaattcca agcccagggt ttggctcctt aaacccgagg 1800
accgccacct cttcccagtg cttgcgacca gcctcattct atttaacttt gctctcagat 1860
gcctcagatg ctataggtca gtgaaagggc aagtagtaag ctgcctgcct cccttccctc 1920
agacctctcc ctcataattc cagagaaggg catttctgtc tttttaagca cagactaagg 1980
ctggaacagt ccatccttat ccctcttctg gcttgggccc tgacacctaa gtctttccca 2040
cggtttatgt gtgtgcctca ttcctttccc accaagaatc catcttagcg cctcctgcca 2100
gctgccctgg tgctttctcc aagggccatc agtgtcttgc ctagcttgag ggcttaagtc 2160
cttatgctgt gttagtttcg ttgtcagaac aaattaaaat tttcagagac gctgctggaa 2220
aaa 2223
<210> 53
<211> 2658
<212> DNA
<213> Homo sapiens
<400> 53
tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60
aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120
agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct taccaatgat 180
gcgagctcag agtcaatagc atccttctct aaacaggagg tcatgagtag ctttctgcca 240
gagggagggt gttacgagct gctcactgtg ataggcaaag gatttgagga cctgatgact 300
gtgaatctag caaggtacaa accaacagga gagtacgtga ctgtacggag gattaaccta 360
gaagcttgtt ccaatgagat ggtaacattc ttgcagggcg agctgcatgt ctccaaactc 420
ttcaaccatc ccaatatcgt gccatatcga gccactttta ttgcagacaa tgagctgtgg 480
gttgtcacat cattcatggc atacggttct gcaaaagatc tcatctgtac acacttcatg 540
gatggcatga atgagctggc gattgcttac atcctgcagg gggtgctgaa ggccctcgac 600
tacatccacc acatgggata tgtacacagg agtgtcaaag ccagccacat cctgatctct 660
gtggatggga aggtctacct gtctggtttg cgcagcaacc tcagcatgat aagccatggg 720
cagcggcagc gagtggtcca cgattttccc aagtacagtg tcaaggttct gccgtggctc 780
agccccgagg tcctccagca gaatctccag ggttatgatg ccaagtctga catctacagt 840
gtgggaatca cagcctgtga actggccaac ggccatgtcc cctttaagga tatgcctgcc 900
acccagatgc tgctagagaa actgaacggc acagtgccct gcctgttgga taccagcacc 960
atccccgctg aggagctgac catgagccct tcgcgctcag tggccaactc tggcctgagt 1020
gacagcctga ccaccagcac cccccggccc tccaacggtg actcgccctc ccacccctac 1080
caccgaacct tctcccccca cttccaccac tttgtggagc agtgccttca gcgcaacccg 1140
gatgccaggt atccctgctg gcctgggcct gggcttcggg agagcagagg gtgctcagga 1200
gggtaaggcc agggtgtgaa gggacttacc tcccaaaggt tctgcagggg aatctggagc 1260
tacacacagg agggatcagc tcctgggtgt gtcagaggcc agcctgggga gctctggcca 1320
ctgcttccca tgagctgagg gagagggaga ggggacccga ggctgaggca taagtggcag 1380
gatttcggga agctggggac acggcagtga tgctgcggtc tctcctcccc tttccctcca 1440
ggcccagtgc cagcaccctc ctgaaccact ctttcttcaa gcaggtatcg tagccccttc 1500
gttctggttc tggttctagt tctggttcta acaactcaca atccctttag ctttctctcc 1560
cctccctttg aatgagagaa actaccccgc ttccgaagcc cctgaaagac actgctcctt 1620
cctctcatgg agttggctcc gacagcccgt ctgccaccag gccatggttc cttgccccat 1680
ggtgtcctgg gacccagagc aacaggatct gtcacccacc tctctcttct cccccagatc 1740
aagcgacgtg cctcagaggc tttgcccgaa ttgcttcgtc ctgtcacccc catcaccaat 1800
tttgagggca gccagtctca ggaccacagt ggaatctttg gcctggtaac aaacctggaa 1860
gagctggagg tggacgattg ggagttctga gcctctgcaa actgtgcgca ttctccagcc 1920
agggatgcag aggccaccca gaggcccttc ctgagggccg gccacattcc cgccctcctg 1980
ggcagattgg gtagaaagga cattcttcca ggaaagttga ctgctgactg attgggaaag 2040
aaaatcctgg agagacactt cactgctcca aggcttttga gacacaaggg aatctcaaca 2100
accagggatc aggagggtcc aaagccgaca ttcccagtcc tgtgagctca ggtgacctcc 2160
tccgcagaag agagatgctg ctctggccct gggagctgaa ttccaagccc agggtttggc 2220
tccttaaacc cgaggaccgc cacctcttcc cagtgcttgc gaccagcctc attctattta 2280
actttgctct cagatgcctc agatgctata ggtcagtgaa agggcaagta gtaagctgcc 2340
tgcctccctt ccctcagacc tctccctcat aattccagag aagggcattt ctgtcttttt 2400
aagcacagac taaggctgga acagtccatc cttatccctc ttctggcttg ggccctgaca 2460
cctaagtctt tcccacggtt tatgtgtgtg cctcattcct ttcccaccaa gaatccatct 2520
tagcgcctcc tgccagctgc cctggtgctt tctccaaggg ccatcagtgt cttgcctagc 2580
ttgagggctt aagtccttat gctgtgttag tttcgttgtc agaacaaatt aaaattttca 2640
gagacgctgc tggaaaaa 2658
<210> 54
<211> 2194
<212> DNA
<213> Homo sapiens
<400> 54
tgcgcatggc acgttgcgta ctcccctccc agcaaccggt ctggcggcgg cgcggcagta 60
aaactgagga ggcggagcca agacggtcgg ggctgcttgc taactccagg aacaggttta 120
agtttttgaa actgaagtag gcctacacag taggaactca tgtcatttct tgtaagtaaa 180
ccagagcgaa tcaggcggtg ggtctcggaa aagttcattg ttgagggctt aagagatttg 240
gaactatttg gagaccaatg atgcgagctc agagtcaata gcatccttct ctaaacagga 300
ggtcatgagt agctttctgc cagagggagg gtgttacgag ctgctcactg tgataggcaa 360
aggatttgag gacctgatga ctgtgaatct agcaaggtac aaaccaacag gagagtacgt 420
gactgtacgg aggattaacc tagaagcttg ttccaatgag atggtaacat tcttgcaggg 480
cgagctgcat gtctccaaac tcttcaacca tcccaatatc gtgccatatc gagccacttt 540
tattgcagac aatgagctgt gggttgtcac atcattcatg gcatacggtt ctgcaaaaga 600
tctcatctgt acacacttca tggatggcat gaatgagctg gcgattgctt acatcctgca 660
gggggtgctg aaggccctcg actacatcca ccacatggga tatgtacaca ggagtgtcaa 720
agccagccac atcctgatct ctgtggatgg gaaggtctac ctgtctggtt tgcgcagcaa 780
cctcagcatg ataagccatg ggcagcggca gcgagtggtc cacgattttc ccaagtacag 840
tgtcaaggtt ctgccgtggc tcagccccga ggtcctccag cagaatctcc agggttatga 900
tgccaagtct gacatctaca gtgtgggaat cacagcctgt gaactggcca acggccatgt 960
cccctttaag gatatgcctg ccacccagat gctgctagag aaactgaacg gcacagtgcc 1020
ctgcctgttg gataccagca ccatccccgc tgaggagctg accatgagcc cttcgcgctc 1080
agtggccaac tctggcctga gtgacagcct gaccaccagc accccccggc cctccaacgg 1140
tgactcgccc tcccacccct accaccgaac cttctccccc cacttccacc actttgtgga 1200
gcagtgcctt cagcgcaacc cggatgccag gcccagtgcc agcaccctcc tgaaccactc 1260
tttcttcaag cagatcaagc gacgtgcctc agaggctttg cccgaattgc ttcgtcctgt 1320
cacccccatc accaattttg agggcagcca gtctcaggac cacagtggaa tctttggcct 1380
ggtaacaaac ctggaagagc tggaggtgga cgattgggag ttctgagcct ctgcaaactg 1440
tgcgcattct ccagccaggg atgcagaggc cacccagagg cccttcctga gggccggcca 1500
cattcccgcc ctcctgggca gattgggtag aaaggacatt cttccaggaa agttgactgc 1560
tgactgattg ggaaagaaaa tcctggagag acacttcact gctccaaggc ttttgagaca 1620
caagggaatc tcaacaacca gggatcagga gggtccaaag ccgacattcc cagtcctgtg 1680
agctcaggtg acctcctccg cagaagagag atgctgctct ggccctggga gctgaattcc 1740
aagcccaggg tttggctcct taaacccgag gaccgccacc tcttcccagt gcttgcgacc 1800
agcctcattc tatttaactt tgctctcaga tgcctcagat gctataggtc agtgaaaggg 1860
caagtagtaa gctgcctgcc tcccttccct cagacctctc cctcataatt ccagagaagg 1920
gcatttctgt ctttttaagc acagactaag gctggaacag tccatcctta tccctcttct 1980
ggcttgggcc ctgacaccta agtctttccc acggtttatg tgtgtgcctc attcctttcc 2040
caccaagaat ccatcttagc gcctcctgcc agctgccctg gtgctttctc caagggccat 2100
cagtgtcttg cctagcttga gggcttaagt ccttatgctg tgttagtttc gttgtcagaa 2160
caaattaaaa ttttcagaga cgctgctgga aaaa 2194
Claims (14)
- 하기 단계를 포함하는, EGFR 억제제를 사용한 치료에 대한 암 환자의 반응을 예측하는 시험관내 방법:
환자의 종양 샘플에서의 표 3에서 선택된 하나 이상의 유전자의 발현 수준을 측정하고, 하나 이상의 유전자의 발현 수준을, EGFR 억제제 치료로부터 임상적 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값에 대해 비교하는 단계 (여기서 환자의 종양 샘플에서의 하나 이상의 유전자의 차등 발현 수준은 치료로부터 임상적 이득을 얻을 환자에 대한 표식임). - 제 1 항에 있어서, 발현 수준을 마이크로어레이 (microarray) 기술로 측정하는 방법.
- 제 1 항 또는 제 2 항에 있어서, 두 유전자의 발현 수준을 측정하는 방법.
- 제 1 항 내지 제 3 항 중 어느 한 항에 있어서, 세 유전자의 발현 수준을 측정하는 방법.
- 제 1 항 내지 제 4 항 중 어느 한 항에 있어서, 유전자가 ATP6V0E1, MAPRE1, PSMA5, ACSL3, RAP1A, SLC2A3, CHMP2B, RFK, CTGF, HSPA8, AKAP12, LOX, SLMO2, NOMO3, APOO로 이루어지는 군에서 선택되며, 상기 유전자가 EGFR 억제제 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 낮은 발현 수준을 나타내는 방법.
- 제 1 항 내지 제 4 항 중 어느 한 항에 있어서, 유전자가 SDC1, CEBPA, ST6GALNAC2, PLA2G6, PMS2L11, C19orf7, DDX17, SFPQ, PMS2L3, SLC35E2, PMSL2, URG4, PPP1R13B, NRCAM, FLJ10916, FLJ13197, GPR172B, ZNF506, ARHGAP8, CELSR1, LYK5로 이루어지는 군에서 선택되며, 상기 유전자가 EGFR 억제제 치료로부터 임상적인 이득을 얻지 못한 환자 집단의 종양에서의 하나 이상의 유전자의 발현 수준의 대표값과 비교하여 환자의 종양 샘플에서 더 높은 발현 수준을 나타내는 방법.
- 제 1 항 내지 제 6 항 중 어느 한 항에 있어서, EGFR 억제제가 에를로티니브인 방법.
- 제 1 항 내지 제 7 항 중 어느 한 항에 있어서, 암이 NSCLC인 방법.
- EGFR 억제제 치료에 대한 암 환자의 반응을 예측하기 위한 표 3에 열거된 유전자의 용도.
- 제 9 항에 있어서, 암이 NSCLC인 용도.
- 제 9 항 또는 제 10 항에 있어서, EGFR 억제제가 에를로티니브인 용도.
- EGFR 억제제를 환자에게 투여하는 것을 포함하는, 제 1 항 내지 제 8 항 중 어느 한 항에 따른 방법에 의해 확인되는 암 환자 치료 방법.
- 제 12 항에 있어서, EGFR 억제제가 에를로티니브인 방법.
- 제 12 항 또는 제 13 항에 있어서, 암이 NSCLC인 방법.
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JP (1) | JP2010535517A (ko) |
KR (1) | KR20100037637A (ko) |
CN (1) | CN101778954A (ko) |
AU (1) | AU2008286407A1 (ko) |
BR (1) | BRPI0815415A2 (ko) |
CA (1) | CA2695485A1 (ko) |
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WO2010121238A2 (en) * | 2009-04-17 | 2010-10-21 | Translational Genomics Research Institute (Tgen) | Methods and kits to predict therapeutic outcome of tyrosine kinase inhibitors |
CN108732350A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Pla2g6作为指示肝内结节及早期预警肝癌的生物标志物 |
CN108732349A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Lta4h作为指示肝内结节及早期预警肝癌的生物标志物 |
CN108732351A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Eps8l2作为指示肝内结节及早期预警肝癌的生物标志物 |
CN110780072B (zh) * | 2019-12-09 | 2021-08-06 | 四川大学华西医院 | Apoo自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
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US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
AU2001251613A1 (en) * | 2000-04-14 | 2001-10-30 | Millennum Pharmaceuticals, Inc. | Novel genes, compositions and methods for the identification, assessment, prevention, and therapy of human cancers |
AU2004211955B2 (en) * | 2003-02-06 | 2009-05-14 | Cedars-Sinai Medical Center | Gene expression markers for response to EGFR inhibitor drugs |
MXPA05012939A (es) * | 2003-05-30 | 2006-05-17 | Astrazeneca Uk Ltd | Procedimiento. |
US8093011B2 (en) | 2005-03-16 | 2012-01-10 | Haley John D | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors |
AR053272A1 (es) * | 2005-05-11 | 2007-04-25 | Hoffmann La Roche | Determinacion de responsivos a la quimioterapia |
WO2007067500A2 (en) * | 2005-12-05 | 2007-06-14 | Genomic Health, Inc. | Predictors of patient response to treatment with egfr inhibitors |
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WO2009021674A1 (en) | 2009-02-19 |
BRPI0815415A2 (pt) | 2015-02-03 |
EP2188391A1 (en) | 2010-05-26 |
CN101778954A (zh) | 2010-07-14 |
CA2695485A1 (en) | 2009-02-19 |
MX2010001571A (es) | 2010-03-15 |
JP2010535517A (ja) | 2010-11-25 |
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