DE69841171D1 - Reaktionsstellenarray, Verfahren zu seiner Herstellung, Reaktionsverfahren unter seiner Verwendung und quantitatives Bestimmungsverfahren für eine Substanz in einer Probelösung unter seiner Verwendung - Google Patents
Reaktionsstellenarray, Verfahren zu seiner Herstellung, Reaktionsverfahren unter seiner Verwendung und quantitatives Bestimmungsverfahren für eine Substanz in einer Probelösung unter seiner VerwendungInfo
- Publication number
- DE69841171D1 DE69841171D1 DE69841171T DE69841171T DE69841171D1 DE 69841171 D1 DE69841171 D1 DE 69841171D1 DE 69841171 T DE69841171 T DE 69841171T DE 69841171 T DE69841171 T DE 69841171T DE 69841171 D1 DE69841171 D1 DE 69841171D1
- Authority
- DE
- Germany
- Prior art keywords
- reaction
- region
- site array
- reaction site
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 10
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000004445 quantitative analysis Methods 0.000 title 1
- 239000012488 sample solution Substances 0.000 title 1
- 239000007788 liquid Substances 0.000 abstract 3
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezoelectric or ink jet dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00617—Delimitation of the attachment areas by chemical means
- B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00729—Peptide nucleic acids [PNA]
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20783897 | 1997-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69841171D1 true DE69841171D1 (de) | 2009-11-05 |
Family
ID=16546369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69841171T Expired - Lifetime DE69841171D1 (de) | 1997-08-01 | 1998-07-31 | Reaktionsstellenarray, Verfahren zu seiner Herstellung, Reaktionsverfahren unter seiner Verwendung und quantitatives Bestimmungsverfahren für eine Substanz in einer Probelösung unter seiner Verwendung |
Country Status (5)
Country | Link |
---|---|
US (2) | US6548020B2 (de) |
EP (1) | EP0895083B1 (de) |
AT (1) | ATE443866T1 (de) |
CA (1) | CA2244414A1 (de) |
DE (1) | DE69841171D1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2798675B1 (fr) * | 1999-09-16 | 2004-02-27 | Centre Nat Rech Scient | Procede et dispositif de fabrication d'un support porteur d'une pluralite de sequences polynucleotidiques et/ou peptidiques differentes |
KR100792021B1 (ko) | 2000-03-30 | 2008-01-04 | 가부시키가이샤 에바라 세이사꾸쇼 | 반응성 탐식자 칩 및 그 제조방법 |
JP4147234B2 (ja) * | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
AU2000275323A1 (en) * | 2000-09-27 | 2002-04-08 | Centre National De La Recherche Scientifique (C.N.R.S.) | Method and device for making a support bearing a plurality of different polynucleotide and/or peptide sequences |
US7407746B2 (en) | 2001-02-08 | 2008-08-05 | Ngk Insulators, Ltd. | Biochip and method for producing the same |
WO2002066984A2 (en) * | 2001-02-16 | 2002-08-29 | Pepscan Systems B.V. | Arrays for determining binding of biomolecules |
US6852524B2 (en) | 2001-04-27 | 2005-02-08 | Canon Kabushiki Kaisha | Probe carrier, probe fixing carrier and method of manufacturing the same |
WO2003020966A2 (de) * | 2001-08-27 | 2003-03-13 | Zeptosens Ag | Oberfläche zur immobilisierung von nukleinsäuren |
KR100455293B1 (ko) * | 2002-05-15 | 2004-11-06 | 삼성전자주식회사 | 친수성 영역과 소수성 영역으로 구성되는 생물분자용어레이 판의 제조방법 |
EP2159285B1 (de) | 2003-01-29 | 2012-09-26 | 454 Life Sciences Corporation | Verfahren zur Verstärkung und Sequenzierung von Nukleinsäuren |
US20050064482A1 (en) * | 2003-08-27 | 2005-03-24 | Norihisa Mino | Microchip, process of manufacturing the same, and analytical method using the same |
US20050208769A1 (en) * | 2004-03-19 | 2005-09-22 | Manish Sharma | Semiconductor structure |
US20050233366A1 (en) * | 2004-04-16 | 2005-10-20 | Norihisa Mino | Sample-analyzing device and process for manufacturing the same |
US20090042741A1 (en) * | 2004-05-06 | 2009-02-12 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University | Microarray of three-dimensional heteropolymer microstructures and method therefor |
JP4147235B2 (ja) * | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、液滴化方法、液体吐出カートリッジ及び吐出装置 |
US20060246467A1 (en) * | 2004-11-15 | 2006-11-02 | California Institute Of Technology | Biomarker sensors and method for multi-color imaging and processing of single-molecule life signatures |
WO2006112709A2 (en) * | 2005-04-18 | 2006-10-26 | Dsm Ip Assets B.V. | Biochip and process for the production of a biochip |
JP4641476B2 (ja) * | 2005-09-15 | 2011-03-02 | キヤノン株式会社 | プローブアレイの製造装置 |
US20070134784A1 (en) * | 2005-12-09 | 2007-06-14 | Halverson Kurt J | Microreplicated microarrays |
US20100230610A1 (en) * | 2006-03-28 | 2010-09-16 | Koninklijke Philips Electronics N.V. | Integrated device having an array of photodetectors and an array of sample sites |
KR100834745B1 (ko) * | 2006-12-20 | 2008-06-09 | 삼성전자주식회사 | 분석 친화적 레이아웃에 기반한 올리고머 프로브 어레이칩, 이의 제조에 사용되는 마스크 및 이의 혼성화 분석방법 |
GB0807242D0 (en) * | 2008-04-21 | 2008-05-28 | Renishaw Plc | Metrological scale |
JP4667490B2 (ja) * | 2008-07-09 | 2011-04-13 | 三菱電機株式会社 | 加熱調理器 |
EP2380022B1 (de) * | 2008-12-11 | 2017-04-05 | Koninklijke Philips N.V. | Wahrnehmungsvorrichtung zum nachweisen von zielelementen in einer flüssigkeit |
WO2011067234A2 (en) * | 2009-12-02 | 2011-06-09 | Roche Diagnostics Gmbh | Multiplexed microarray and method of fabricating thereof |
US8753873B2 (en) | 2011-04-15 | 2014-06-17 | Roche Nimblegen, Inc. | Multiplexed microarray assembly and method for fabricating a multiplexed microarray |
DE102013210138A1 (de) * | 2013-05-30 | 2014-12-04 | Boehringer Ingelheim Vetmedica Gmbh | Verfahren zum Erzeugen einer Vielzahl von Messbereichen auf einem Chip sowie Chip mit Messbereichen |
KR20160073016A (ko) * | 2014-12-16 | 2016-06-24 | 삼성전자주식회사 | 광학분석용 구조체 및 광학분석용 구조체 제조용 잉크 조성물 |
GB201520341D0 (en) | 2015-11-18 | 2015-12-30 | Randox Lab Ltd And Randox Teoranta | Improvements relating to substrates for the attachment of molecules |
KR20180088722A (ko) | 2015-12-02 | 2018-08-06 | 베링거잉겔하임베트메디카게엠베하 | 칩 상에 다수의 측정 영역들을 제조하는 방법 및 다수의 측정 영역들을 갖는 칩 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000334A (en) * | 1971-07-15 | 1976-12-28 | Energy Conversion Devices, Inc. | Thermal imaging involving imagewise melting to form spaced apart globules |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5846708A (en) | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5441894A (en) * | 1993-04-30 | 1995-08-15 | Abbott Laboratories | Device containing a light absorbing element for automated chemiluminescent immunoassays |
JPH07179797A (ja) * | 1993-12-24 | 1995-07-18 | Canon Inc | バブルジェット用記録液およびそれを用いた記録方法 |
US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6121048A (en) * | 1994-10-18 | 2000-09-19 | Zaffaroni; Alejandro C. | Method of conducting a plurality of reactions |
US5688642A (en) | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
JPH0954093A (ja) * | 1995-08-18 | 1997-02-25 | Adtec Kk | 抗原や抗体の固相方法 |
US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
-
1998
- 1998-07-31 CA CA002244414A patent/CA2244414A1/en not_active Abandoned
- 1998-07-31 DE DE69841171T patent/DE69841171D1/de not_active Expired - Lifetime
- 1998-07-31 AT AT98306110T patent/ATE443866T1/de not_active IP Right Cessation
- 1998-07-31 US US09/126,856 patent/US6548020B2/en not_active Expired - Fee Related
- 1998-07-31 EP EP98306110A patent/EP0895083B1/de not_active Expired - Lifetime
-
2003
- 2003-02-07 US US10/359,603 patent/US20030119179A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2244414A1 (en) | 1999-02-01 |
EP0895083B1 (de) | 2009-09-23 |
EP0895083A2 (de) | 1999-02-03 |
ATE443866T1 (de) | 2009-10-15 |
EP0895083A3 (de) | 1999-08-11 |
US20020150506A1 (en) | 2002-10-17 |
US6548020B2 (en) | 2003-04-15 |
US20030119179A1 (en) | 2003-06-26 |
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