DE69839373D1 - Auf die Verwendung von nukleaseresistenten Fragmenten basierende Verfahren und Kits, die für Nukleinsäuretests mit hohem Durchsatz geeignet sind - Google Patents

Auf die Verwendung von nukleaseresistenten Fragmenten basierende Verfahren und Kits, die für Nukleinsäuretests mit hohem Durchsatz geeignet sind

Info

Publication number
DE69839373D1
DE69839373D1 DE69839373T DE69839373T DE69839373D1 DE 69839373 D1 DE69839373 D1 DE 69839373D1 DE 69839373 T DE69839373 T DE 69839373T DE 69839373 T DE69839373 T DE 69839373T DE 69839373 D1 DE69839373 D1 DE 69839373D1
Authority
DE
Germany
Prior art keywords
high throughput
nucleic acid
probes
methods based
nuclease resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839373T
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English (en)
Other versions
DE69839373T2 (de
Inventor
Stephen Felder
Richard Kris
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Individual
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Individual
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Application filed by Individual filed Critical Individual
Publication of DE69839373D1 publication Critical patent/DE69839373D1/de
Application granted granted Critical
Publication of DE69839373T2 publication Critical patent/DE69839373T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B01J2219/00662—Two-dimensional arrays within two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Fats And Perfumes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE69839373T 1997-12-19 1998-12-21 Auf die Verwendung von nukleaseresistenten Fragmenten basierende Verfahren und Kits, die für Nukleinsäuretests mit hohem Durchsatz geeignet sind Expired - Lifetime DE69839373T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6829197P 1997-12-19 1997-12-19
US68291P 1997-12-19
US109076 1998-07-02
US09/109,076 US6232066B1 (en) 1997-12-19 1998-07-02 High throughput assay system
PCT/US1998/027191 WO1999032663A2 (en) 1997-12-19 1998-12-21 High throughput assay system

Publications (2)

Publication Number Publication Date
DE69839373D1 true DE69839373D1 (de) 2008-05-29
DE69839373T2 DE69839373T2 (de) 2009-06-04

Family

ID=26748811

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839373T Expired - Lifetime DE69839373T2 (de) 1997-12-19 1998-12-21 Auf die Verwendung von nukleaseresistenten Fragmenten basierende Verfahren und Kits, die für Nukleinsäuretests mit hohem Durchsatz geeignet sind

Country Status (19)

Country Link
US (1) US6232066B1 (de)
EP (1) EP1038033B1 (de)
JP (5) JP2001526904A (de)
KR (1) KR100708782B1 (de)
CN (1) CN1292076C (de)
AT (1) ATE392485T1 (de)
AU (2) AU1936699A (de)
CA (1) CA2315776C (de)
CZ (1) CZ302381B6 (de)
DE (1) DE69839373T2 (de)
DK (1) DK1038033T3 (de)
EA (1) EA006425B1 (de)
ES (1) ES2306484T3 (de)
IL (2) IL136862A0 (de)
MX (1) MXPA00006058A (de)
NO (1) NO329977B1 (de)
NZ (1) NZ505319A (de)
PL (1) PL193762B1 (de)
WO (1) WO1999032663A2 (de)

Families Citing this family (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
WO1997040385A1 (en) 1996-04-25 1997-10-30 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US7041510B2 (en) * 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6083763A (en) * 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
WO2000037684A1 (en) * 1998-12-22 2000-06-29 Kris Richard M High throughput assay system using mass spectrometry
CA2318175A1 (en) 1998-02-04 1999-08-12 Invitrogen Corporation Microarrays and uses therefor
CA2335951C (en) 1998-06-24 2013-07-30 Mark S. Chee Decoding of array sensors with microspheres
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6950752B1 (en) * 1998-10-27 2005-09-27 Rosetta Inpharmatics Llc Methods for removing artifact from biological profiles
US6468476B1 (en) * 1998-10-27 2002-10-22 Rosetta Inpharmatics, Inc. Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
AU4058100A (en) * 1999-04-09 2000-11-14 Arcturus Engineering, Inc. Generic cdna or protein array for customized assays
US6221653B1 (en) * 1999-04-27 2001-04-24 Agilent Technologies, Inc. Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
US6395483B1 (en) 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001020593A1 (en) 1999-09-17 2001-03-22 Bioarray Solutions, Llc System and method for programmable illumination pattern generation
US20030036070A1 (en) * 1999-10-21 2003-02-20 Shukti Chakravarti Gene expression profiling of inflammatory bowel disease
US6656432B1 (en) * 1999-10-22 2003-12-02 Ngk Insulators, Ltd. Micropipette and dividedly injectable apparatus
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
JP4873812B2 (ja) * 1999-11-15 2012-02-08 キアジェン ゲイサーズバーグ インコーポレイテッド マイクロアレイ上のｒｎａ：ｄｎａハイブリッドの免疫検出
AU2586001A (en) * 1999-12-21 2001-07-03 Ortho-Clinical Diagnostics, Inc. Detection of nucleic acids
CA2398107C (en) * 2000-01-28 2013-11-19 Althea Technologies, Inc. Methods for analysis of gene expression
EP1257805B1 (de) * 2000-02-10 2015-10-14 Illumina, Inc. Element mit einem substrat mit mehreren immunoassay-stellen zur simultanen analyse mehrerer proben mit hilfe von mikrokugeln, das element enthaltende vorrichtung, und herstellungsverfahren für das element
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
EP1263773A4 (de) 2000-03-14 2005-08-31 Active Motif Analoge von oligonukleotiden, methoden der synthese und methoden der verwendung
CA2302827A1 (en) * 2000-04-12 2001-10-12 Michelle Furtado Oligonucleotide and dna de-hybridization on surfaces
US20030104494A1 (en) * 2001-10-26 2003-06-05 Ilya Ravkin Assay systems with adjustable fluid communication
US7338773B2 (en) * 2000-04-14 2008-03-04 Millipore Corporation Multiplexed assays of cell migration
WO2001083826A2 (en) * 2000-05-03 2001-11-08 Massachusetts Institute Of Technology Methods and reagents for assembling molecules on solid supports
TWI220927B (en) * 2000-05-12 2004-09-11 Rong-Seng Chang Method for producing a micro-carrier
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
EP1311839B1 (de) 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
CN1137999C (zh) * 2000-07-04 2004-02-11 清华大学 集成式微阵列装置
US6913879B1 (en) * 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
EP1301632A2 (de) * 2000-07-19 2003-04-16 Pointilliste, Inc. Eingebettetes sortieren und hochdurchsatzscreening
US7678539B2 (en) * 2000-08-10 2010-03-16 Corning Incorporated Arrays of biological membranes and methods and use thereof
EP1314035A1 (de) * 2000-08-14 2003-05-28 Surface Logix, Inc. Biomolekuläre matrizen
WO2002016647A1 (en) * 2000-08-24 2002-02-28 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US6900013B1 (en) * 2000-08-25 2005-05-31 Aviva Biosciences Corporation Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
US20020081589A1 (en) * 2000-10-12 2002-06-27 Jing-Shan Hu Gene expression monitoring using universal arrays
AU2001297830A1 (en) * 2000-10-25 2002-12-09 Exiqon A/S Closed substrate platforms suitable for analysis of biomolecules
AU2002230419A1 (en) * 2000-11-08 2002-05-21 Science And Technology Corporation @Unm Fluorescence and fret based assays for biomolecules on beads
WO2002084302A2 (en) 2000-11-08 2002-10-24 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
US7351575B2 (en) * 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US6905881B2 (en) 2000-11-30 2005-06-14 Paul Sammak Microbead-based test plates and test methods for fluorescence imaging systems
WO2002047071A2 (en) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Multiple data layer optical discs for detecting analytes
US6760298B2 (en) 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
US7079468B2 (en) 2000-12-08 2006-07-18 Burstein Technologies, Inc. Optical discs for measuring analytes
US7776571B2 (en) * 2000-12-12 2010-08-17 Autogenomics, Inc. Multi-substrate biochip unit
US6869766B2 (en) * 2000-12-22 2005-03-22 The Regents Of The University Of California Gene associated with regulation of adiposity and insulin response
AU2002231189A1 (en) * 2000-12-22 2002-07-08 Burstein Technologies, Inc. Optical bio-discs and methods relating thereto
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
US6949638B2 (en) * 2001-01-29 2005-09-27 Affymetrix, Inc. Photolithographic method and system for efficient mask usage in manufacturing DNA arrays
WO2002063270A2 (en) * 2001-02-05 2002-08-15 Board Of Regents, The University Of Texas System The use of mesoscale self-assembly and recognition to effect delivery of sensing reagent for arrayed sensors
JP2002251091A (ja) * 2001-02-27 2002-09-06 Konica Corp 画像定着装置および画像形成装置
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US20030170623A1 (en) * 2001-04-13 2003-09-11 Jingwen Chen Multiplexed gene analysis on a mobile solid support
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
KR20020089746A (ko) * 2001-05-24 2002-11-30 주식회사 커벡스 크기변형유도 앵커 시발체, 이를 이용한 알티-피씨알 방법및 이를 이용한 진단 방법
US20030096264A1 (en) * 2001-06-18 2003-05-22 Psychiatric Genomics, Inc. Multi-parameter high throughput screening assays (MPHTS)
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US7727713B2 (en) * 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US20060073610A1 (en) * 2001-07-06 2006-04-06 Millpore Corporation Patterned composite membrane and stenciling method for the manufacture thereof
US7141416B2 (en) 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
EP1572896A4 (de) * 2001-07-30 2006-06-07 Angiotech Biocoatings Corp Pfropfpolymermatrizes
WO2003019192A1 (en) * 2001-08-27 2003-03-06 The Trustees Of Boston University Apparatus, composition and method for proteome profiling
US20030044320A1 (en) * 2001-08-31 2003-03-06 Shun Luo High throughput screening micro array platform
GB0124338D0 (en) * 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
JP4377689B2 (ja) 2001-10-15 2009-12-02 バイオアレイ ソリューションズ リミテッド 同時尋問及び酵素仲介検出による多型遺伝子座の複合分析
US20080187949A1 (en) * 2001-10-26 2008-08-07 Millipore Corporation Multiplexed assays of cell migration
US7381375B2 (en) * 2001-10-26 2008-06-03 Millipore Corporation Assay systems with adjustable fluid communication
WO2003046508A2 (en) 2001-11-09 2003-06-05 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
WO2003045310A2 (en) * 2001-11-21 2003-06-05 Applera Corporation Digital assay
KR20030049802A (ko) * 2001-12-17 2003-06-25 권윤정 바이오 칩에서 프로브와 시료 핵산의 혼성화 여부를 효소반응으로 구별하는 방법
US20070178477A1 (en) * 2002-01-16 2007-08-02 Nanomix, Inc. Nanotube sensor devices for DNA detection
US20060228723A1 (en) * 2002-01-16 2006-10-12 Keith Bradley System and method for electronic sensing of biomolecules
US6989235B2 (en) * 2002-02-13 2006-01-24 Motorola, Inc. Single molecule detection of bio-agents using the F1-ATPase biomolecular motor
EP1487978B1 (de) 2002-03-15 2008-11-19 Nuevolution A/S Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
CA2523626A1 (en) * 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
EP1511863A4 (de) * 2002-05-14 2006-12-27 Univ Leland Stanford Junior Endometriale gene bei erkrankungen des endometriums
US6841379B2 (en) 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
CA2487093A1 (en) * 2002-05-24 2003-12-04 Nimblegen Systems, Inc. Microarrays and method for running hybridization reaction for multiple samples on a single microarray
US20030232384A1 (en) * 2002-06-13 2003-12-18 Eastman Kodak Company Microarray system utilizing microtiter plates
US7108976B2 (en) * 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
US20040053399A1 (en) * 2002-07-17 2004-03-18 Rudolf Gilmanshin Methods and compositions for analyzing polymers using chimeric tags
US10730906B2 (en) * 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
WO2004028682A2 (en) * 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
US7459273B2 (en) * 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
CN106337046B (zh) * 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
US20060134704A1 (en) * 2002-11-14 2006-06-22 Atsushi Muraguchi Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
AU2003293511A1 (en) * 2002-12-11 2004-06-30 Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597577A4 (de) * 2003-02-10 2007-02-21 Pointilliste Inc Selbstanordnende arrays und ihre anwendung
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
WO2004097371A2 (en) * 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
WO2004104177A2 (en) * 2003-05-15 2004-12-02 Integrated Nano-Technologies, Llc Methods for localizing target molecules in a flowing fluid sample
WO2004104922A2 (en) * 2003-05-16 2004-12-02 Board Of Regents, The University Of Texas System Image and part recognition technology
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
EP3323877B1 (de) * 2003-06-12 2022-04-20 Accupath Diagnostic Laboratories, Inc. Verfahren zur herstellung eines zellarray
US20040265883A1 (en) * 2003-06-27 2004-12-30 Biocept, Inc. mRNA expression analysis
US8114978B2 (en) 2003-08-05 2012-02-14 Affymetrix, Inc. Methods for genotyping selected polymorphism
AU2004286201B2 (en) * 2003-09-10 2010-09-09 Altheadx, Inc. Expression profiling using microarrays
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
DK1670939T3 (da) 2003-09-18 2010-03-01 Nuevolution As Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
JP4564959B2 (ja) 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
DK1691196T3 (da) * 2003-09-25 2013-04-15 Vivalis Chip med mikrobrøndsarray og fremgangsmåde til fremstilling heraf
CA2899287A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
WO2005050170A2 (en) * 2003-11-17 2005-06-02 Auburn University Methods and compositions for inhibiting intracellular aggregate formation
US7651868B2 (en) * 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
WO2005059086A1 (en) * 2003-12-16 2005-06-30 Canon Kabushiki Kaisha Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same
US7977048B2 (en) * 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
JP2007529758A (ja) * 2004-03-19 2007-10-25 ユー．エス． ジェノミクス， インコーポレイテッド 単一分子の検出のための組成物および方法
WO2005118806A2 (en) * 2004-05-28 2005-12-15 Ambion, Inc. METHODS AND COMPOSITIONS INVOLVING MicroRNA
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CN100352937C (zh) * 2004-08-06 2007-12-05 中国海洋大学 对藻类进行定性与定量分析的方法
WO2006024023A2 (en) * 2004-08-24 2006-03-02 Nanomix, Inc. Nanotube sensor devices for dna detection
US20060078894A1 (en) * 2004-10-12 2006-04-13 Winkler Matthew M Methods and compositions for analyzing nucleic acids
ES2534300T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US7452671B2 (en) * 2005-04-29 2008-11-18 Affymetrix, Inc. Methods for genotyping with selective adaptor ligation
CA2607454A1 (en) * 2005-05-03 2006-11-09 Althea Technologies, Inc. Compositions and methods for the analysis of degraded nucleic acids
CA2610793A1 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070081163A1 (en) * 2005-06-03 2007-04-12 Minhua Liang Method and apparatus for scanned beam microarray assay
CA2613078A1 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
WO2007056250A2 (en) * 2005-11-04 2007-05-18 U.S. Genomics, Inc. Heterogeneous assay of analytes in solution using polymers
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
DK2336315T3 (da) * 2005-12-01 2017-11-06 Nuevolution As Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
JPWO2007074747A1 (ja) * 2005-12-26 2009-06-04 株式会社クラレ 細胞培養用材料
US20090176208A1 (en) * 2006-01-04 2009-07-09 Simon Brodie Methods for detecting, identifying and reporting the presence of animal pathological agents
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
WO2007140015A2 (en) * 2006-05-26 2007-12-06 Althea Technologies, Inc Biochemical analysis of partitioned cells
WO2008036776A2 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention
US9957157B2 (en) * 2006-09-19 2018-05-01 University of Houtson System Fabrication of self assembling nano-structures
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
AU2007333106A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. miR-20 regulated genes and pathways as targets for therapeutic intervention
EP2104735A2 (de) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-21-regulierte gene und pfade als ziele für therapeutische interventionen
US20090092974A1 (en) * 2006-12-08 2009-04-09 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
CN101675165A (zh) * 2006-12-08 2010-03-17 奥斯瑞根公司 Let-7微小rna的功能和靶标
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
WO2008154333A2 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
WO2009009127A2 (en) * 2007-07-12 2009-01-15 U.S. Genomics, Inc. Method and system for transferring and/or concentrating a sample
JP4148367B1 (ja) 2007-08-02 2008-09-10 富山県 細胞のスクリーニング方法
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
EP2198050A1 (de) * 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
US8071562B2 (en) * 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US20090192114A1 (en) * 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
US20090263803A1 (en) * 2008-02-08 2009-10-22 Sylvie Beaudenon Mirnas differentially expressed in lymph nodes from cancer patients
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
EP2271757A2 (de) * 2008-03-26 2011-01-12 Asuragen, INC. Zusammensetzungen und verfahren in zusammenhang mit mir-16 und prostatakrebstherapie
CN102046809A (zh) * 2008-04-05 2011-05-04 单细胞科技公司 筛选产生生物活性剂的单细胞的方法
WO2009126726A1 (en) * 2008-04-08 2009-10-15 Asuragen, Inc Methods and compositions for diagnosing and modulating human papillomavirus (hpv)
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
CA2726426A1 (en) * 2008-06-04 2009-12-10 The Arizona Board Of Regents, On Behalf Of The University Of Arizona Diffuse large b-cell lymphoma markers and uses therefor
WO2010052307A2 (de) * 2008-11-07 2010-05-14 Roche Diagnostics Gmbh Testelement für den nachweis eines analyten in einer probe
WO2010056737A2 (en) * 2008-11-11 2010-05-20 Mirna Therapeutics, Inc. Methods and compositions involving mirnas in cancer stem cells
JP5745752B2 (ja) * 2009-05-21 2015-07-08 オリンパス株式会社 細胞スクリーニング方法、その方法に用いる制御ソフトウェア、細胞スクリーニング装置、及び画像解析装置、並びに細胞スクリーニングシステム
CA2778249C (en) 2009-11-03 2018-12-04 Htg Molecular Diagnostics, Inc. Quantitative nuclease protection sequencing (qnps)
EP3540059A1 (de) 2010-04-16 2019-09-18 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
US8741564B2 (en) 2011-05-04 2014-06-03 Htg Molecular Diagnostics, Inc. Quantitative nuclease protection assay (QNPA) and sequencing (QNPS) improvements
EP2726628B1 (de) 2011-07-01 2016-05-11 HTG Molecular Diagnostics, Inc. Verfahren zum nachweis von genfusionen
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013039228A1 (ja) * 2011-09-14 2013-03-21 日本碍子株式会社 標的核酸の検出方法
WO2013058739A1 (en) * 2011-10-18 2013-04-25 Hewlett-Packard Development Company, L.P. Molecular sensing device
JP6366580B2 (ja) 2012-06-22 2018-08-01 エイチティージー モレキュラー ダイアグノスティクス， インコーポレイテッド メラニン細胞性病変における分子悪性度
CA2877729C (en) 2012-06-29 2020-11-17 Htg Molecular Diagnostics, Inc. Nuclease protection methods for detection of nucleotide variants
CN104769410B (zh) 2012-11-06 2018-07-27 拜奥－多特公司 用于核型分析的细胞样本的受控印刷
TW202206465A (zh) 2012-11-14 2022-02-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
WO2014150853A1 (en) * 2013-03-15 2014-09-25 Inanovate, Inc. Analyte measurement using longitudinal assay
US11198900B2 (en) 2014-12-06 2021-12-14 Children's Medical Center Corporation Nucleic acid-based linkers for detecting and measuring interactions
US11396650B2 (en) 2015-06-02 2022-07-26 Children's Medical Center Corporation Nucleic acid complexes for screening barcoded compounds
JP6836586B2 (ja) 2015-09-29 2021-03-03 エイチティージー モレキュラー ダイアグノスティクス， インコーポレイテッド びまん性大細胞型ｂ細胞性リンパ腫（ｄｌｂｃｌ）を亜型決定するための方法
US11713483B2 (en) 2016-02-09 2023-08-01 Children's Medical Center Corporation Method for detection of analytes via polymer complexes
US20190009240A1 (en) * 2017-07-10 2019-01-10 The Charles Stark Draper Laboratory, Inc. Apparatus Enabling High Density Information Storage in Molecular Chains
WO2019069372A1 (ja) * 2017-10-03 2019-04-11 株式会社ニコン 検出対象の測定方法、捕捉プローブ固定化担体、検出キット、及び流体デバイス
US11591636B2 (en) 2017-11-20 2023-02-28 Children's Medical Center Corporation Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
WO2019222650A1 (en) 2018-05-17 2019-11-21 The Charles Stark Draper Laboratory, Inc. Apparatus for high density information storage in molecular chains
GB2599709A (en) * 2020-10-09 2022-04-13 Qbd Qs Ip Ltd Analysis system and method

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228237A (en) 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4925785A (en) 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5374524A (en) 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
AU632494B2 (en) 1988-05-20 1993-01-07 F. Hoffmann-La Roche Ag Immobilized sequence-specific probes
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
JPH05502585A (ja) * 1989-12-04 1993-05-13 ベクトン　ディッキンソン　アンド　カンパニー ポリマーに共有結合したオリゴヌクレオチドの利用により向上される標的核酸の捕獲
AU7762091A (en) 1990-03-30 1991-10-30 City Of Hope Detection of minimal residual disease in lymphoid malignancies
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
ES2092056T3 (es) 1991-09-23 1996-11-16 Pfizer Procedimiento para detectar arnm y adn especificos en celulas.
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
US5985583A (en) * 1992-06-23 1999-11-16 Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of gonadotropin-releasing hormone receptor
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5789165A (en) 1993-05-10 1998-08-04 Nissui Pharmaceutical Co., Ltd. Method and reagent for simultaneously assaying one or more ligands in a group of preselected ligands
JPH079468A (ja) * 1993-06-24 1995-01-13 Sekisui Chem Co Ltd 熱可塑性樹脂成型体の製造方法
DE19518217A1 (de) 1994-05-11 1995-11-30 Imtec Immundiagnostika Gmbh Verfahren und Vorrichtung zur qualitativen und quantitativen Bestimmung von Desoxyribonukleinsäure (DNA) auf festen Phasen
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
DE19516196A1 (de) 1995-05-08 1996-11-14 Boehringer Mannheim Gmbh Verfahren zum quantitativen Nachweis von Nukleinsäuren
WO1996035778A1 (en) * 1995-05-11 1996-11-14 Human Genome Sciences, Inc. Human uridine diphosphate galactose-4-epimerase
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
FR2737502B1 (fr) 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
AU6898296A (en) 1995-08-14 1997-03-12 Ely Michael Rabani Methods and devices for parallel multiplex polynucleotide sequencing
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
EP0819167A4 (de) * 1996-01-24 2002-06-12 Synaptic Pharma Corp Dns codierend für galanin galr2 rezeptoren und deren verwendung
EP2332958B1 (de) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detektion von Unterschieden in der Sequenz von Nukleinsäuren mittels der Ligasedetektionsreaktion und adressierbaren Arrays
EP0886681A1 (de) 1996-03-04 1998-12-30 Genetrace Systems, Inc. Verfahren zur suche von nukleinsäuren mit massenspektroskopie
US5770370A (en) 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US6083763A (en) 1996-12-31 2000-07-04 Genometrix Inc. Multiplexed molecular analysis apparatus and method
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
KR100709468B1 (ko) * 2004-11-09 2007-04-18 주식회사 하이닉스반도체 플래시 메모리 소자의 플로팅 게이트 형성방법

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