DK1691196T3 - Chip med mikrobrøndsarray og fremgangsmåde til fremstilling heraf - Google Patents

Chip med mikrobrøndsarray og fremgangsmåde til fremstilling heraf

Info

Publication number
DK1691196T3
DK1691196T3 DK04773462.9T DK04773462T DK1691196T3 DK 1691196 T3 DK1691196 T3 DK 1691196T3 DK 04773462 T DK04773462 T DK 04773462T DK 1691196 T3 DK1691196 T3 DK 1691196T3
Authority
DK
Denmark
Prior art keywords
making
array chip
microwell array
microwell
chip
Prior art date
Application number
DK04773462.9T
Other languages
English (en)
Inventor
Atsushi Muraguchi
Hiroyuki Kishi
Yoshiharu Tokimitsu
Sachiko Kondo
Tsutomu Obata
Satoshi Fujiki
Yoshiyuki Yokoyama
Hirofumi Nabesawa
Sotohiro Takabayashi
Katsumi Tanino
Original Assignee
Vivalis
Toyama Prefecture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivalis, Toyama Prefecture filed Critical Vivalis
Application granted granted Critical
Publication of DK1691196T3 publication Critical patent/DK1691196T3/da

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Sampling And Sample Adjustment (AREA)
DK04773462.9T 2003-09-25 2004-09-22 Chip med mikrobrøndsarray og fremgangsmåde til fremstilling heraf DK1691196T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2003333363 2003-09-25
JP2003336793 2003-09-29
JP2003336771 2003-09-29
PCT/JP2004/014285 WO2005069001A1 (ja) 2003-09-25 2004-09-22 マイクロウェルアレイチップ及びその製造方法

Publications (1)

Publication Number Publication Date
DK1691196T3 true DK1691196T3 (da) 2013-04-15

Family

ID=34799286

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04773462.9T DK1691196T3 (da) 2003-09-25 2004-09-22 Chip med mikrobrøndsarray og fremgangsmåde til fremstilling heraf

Country Status (9)

Country Link
US (2) US20080014631A1 (da)
EP (2) EP1691196B1 (da)
JP (1) JP4069171B2 (da)
KR (1) KR101111231B1 (da)
CN (1) CN102928584B (da)
CA (1) CA2544470C (da)
DK (1) DK1691196T3 (da)
ES (1) ES2411104T3 (da)
WO (1) WO2005069001A1 (da)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154677A0 (en) 2003-02-27 2003-09-17 Univ Bar Ilan A method and apparatus for manipulating an individual cell
US8597597B2 (en) 2003-06-26 2013-12-03 Seng Enterprises Ltd. Picoliter well holding device and method of making the same
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US7888110B2 (en) 2003-06-26 2011-02-15 Seng Enterprises Ltd. Pico liter well holding device and method of making the same
ES2352344T3 (es) 2005-01-25 2011-02-17 Seng Enterprises Limited Dispositivo de microfluido para estudio de células.
US7776553B2 (en) 2005-09-16 2010-08-17 Presidents And Fellows Of Harvard College Screening assays and methods
JP4711125B2 (ja) * 2005-09-27 2011-06-29 横河電機株式会社 バイオチップ、バイオチップ読み取り装置、およびバイオチップ読み取り方法
WO2007046582A1 (en) * 2005-10-21 2007-04-26 Korea Research Institute Of Bioscience And Biotechnology A method for fabricating nanogap and nanogap sensor
KR100849384B1 (ko) * 2005-10-21 2008-07-31 한국생명공학연구원 나노갭 및 나노갭 센서의 제조방법
WO2007052245A1 (en) 2005-11-03 2007-05-10 Seng Enterprises Ltd. Method and device for studying floating, living cells
US7974003B2 (en) 2006-11-22 2011-07-05 Vanderbilt University Photolithographed micro-mirror well for 3D tomogram imaging of individual cells
JP5041473B2 (ja) * 2007-03-06 2012-10-03 国立大学法人山口大学 蛍光テストチャート
WO2008157640A2 (en) * 2007-06-18 2008-12-24 Illumina, Inc. Microfabrication methods for the optimal patterning of substrates
JP4148367B1 (ja) * 2007-08-02 2008-09-10 富山県 細胞のスクリーニング方法
EP2214007B1 (en) * 2007-10-31 2019-05-01 ARKRAY, Inc. Analytical tool
US9975118B2 (en) 2007-11-15 2018-05-22 Seng Enterprises Ltd. Device for the study of living cells
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
US8680023B2 (en) 2008-08-21 2014-03-25 International Business Machines Corporation Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background
WO2010027003A1 (ja) 2008-09-02 2010-03-11 独立行政法人産業技術総合研究所 細胞検出方法及び該方法に用いるマイクロアレイチップ
JP2010151525A (ja) * 2008-12-24 2010-07-08 Seiko Epson Corp 反応場を有するデバイス
US20100204057A1 (en) * 2009-02-10 2010-08-12 Samsung Electronics Co., Ltd. Substrate for microarray, method of manufacturing microarray using the same and method of obtaining light data from microarray
EP2219027A1 (en) * 2009-02-12 2010-08-18 Centre National de la Recherche Scientifique Devices and methods for observing the cell division
US20120129208A1 (en) * 2009-03-18 2012-05-24 Michelle Khine Honeycomb shrink wells for stem cell culture
US20120302462A1 (en) 2009-11-09 2012-11-29 Bjorn Onfelt System and Method for Detecting and Quantifying Active T-cells or Natural Killer Cells
KR101144064B1 (ko) * 2009-12-09 2012-05-23 (주)유 바이오메드 마이크로어레이 칩 및 그의 제조방법
JP5771962B2 (ja) * 2010-12-08 2015-09-02 大日本印刷株式会社 マイクロ流路チップ及びその製造方法
CN102117738B (zh) * 2010-12-31 2013-04-03 中微半导体设备(上海)有限公司 使用含碳氟化合物的聚合物使硅片顶角圆化的方法
US8860227B2 (en) 2011-06-22 2014-10-14 Panasonic Corporation Semiconductor substrate having dot marks and method of manufacturing the same
EP2724157B1 (en) 2011-06-27 2017-03-08 Valneva Method for screening cells
JP2013047625A (ja) * 2011-08-29 2013-03-07 Sumitomo Bakelite Co Ltd マルチウェルプレート
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US20140155295A1 (en) 2012-08-14 2014-06-05 10X Technologies, Inc. Capsule array devices and methods of use
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2931919B1 (en) 2012-12-14 2019-02-20 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN108753766A (zh) 2013-02-08 2018-11-06 10X基因组学有限公司 多核苷酸条形码生成
EP2970851A4 (en) * 2013-03-15 2016-09-21 Douglas Scient Llc REUSABLE BAND WITH A MATRIX OF REINFORCEMENTS
JP2015010910A (ja) * 2013-06-28 2015-01-19 株式会社ニコン 検出方法、検出装置、バイオチップのスクリーニング方法、スクリーニング装置及びバイオチップ
JP2015017940A (ja) * 2013-07-12 2015-01-29 株式会社ニコン 検出方法、検出装置、バイオチップのスクリーニング方法、スクリーニング装置及びバイオチップ
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
JP6330278B2 (ja) * 2013-09-11 2018-05-30 大日本印刷株式会社 培養容器
JP5920375B2 (ja) * 2013-09-11 2016-05-18 大日本印刷株式会社 細胞培養容器
JP6303347B2 (ja) 2013-09-11 2018-04-04 大日本印刷株式会社 検体画像管理システム及び検体画像管理プログラム
JP6277639B2 (ja) * 2013-09-11 2018-02-14 大日本印刷株式会社 培養容器
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
JP2015194379A (ja) * 2014-03-31 2015-11-05 株式会社ニコン バイオチップ及びバイオチップにおけるアライメントマークの検出方法
CA2943624A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
WO2015191684A1 (en) * 2014-06-12 2015-12-17 Wafergen, Inc. Single cell capture with polymer capture films
EP4235677A3 (en) 2014-06-26 2023-11-22 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
EP3212807B1 (en) 2014-10-29 2020-09-02 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016115273A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
AU2016219480B2 (en) 2015-02-09 2021-11-11 10X Genomics, Inc. Systems and methods for determining structural variation and phasing using variant call data
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
JP2016174578A (ja) * 2015-03-20 2016-10-06 東ソー株式会社 微小粒子選別装置および前記装置を備えた微小粒子回収装置
BR112017019906A2 (pt) * 2015-03-31 2018-06-12 Toray Industries, Inc. pedaço de análise
US11136614B2 (en) * 2015-10-07 2021-10-05 Arizona Board Of Regents On Behalf Of Arizona State University Live-cell seeding method for microarrays
CN115369161A (zh) 2015-12-04 2022-11-22 10X 基因组学有限公司 用于核酸分析的方法和组合物
JP2017108738A (ja) * 2015-12-15 2017-06-22 東ソー株式会社 細胞検出装置および細胞回収装置
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
JP7235509B2 (ja) * 2016-04-14 2023-03-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 植え込み可能な生きた電極およびその製造方法
US11408812B2 (en) 2016-04-22 2022-08-09 Becton, Dickinson And Company High density deposition for array production
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
GB201610426D0 (en) * 2016-06-15 2016-07-27 Q-Linea Ab Sample holder for image based analysis of samples
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
JP2020043764A (ja) * 2016-12-28 2020-03-26 Ａｇｃテクノグラス株式会社 細胞培養基材及びその製造方法
WO2018140966A1 (en) 2017-01-30 2018-08-02 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
WO2018163757A1 (ja) * 2017-03-10 2018-09-13 株式会社村田製作所 細胞濾過フィルタ
US11969702B2 (en) * 2017-03-21 2024-04-30 Celldom, Inc. Sealed microwell assay
JP7063541B2 (ja) * 2017-03-31 2022-05-09 住友理工株式会社 流体デバイス用シリコーン部材およびその製造方法
CN110870018A (zh) 2017-05-19 2020-03-06 10X基因组学有限公司 用于分析数据集的系统和方法
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP4230746A3 (en) 2017-05-26 2023-11-01 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3727136B1 (en) 2017-12-21 2023-10-04 Politecnico di Milano Implantable medical device
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
JP2018124289A (ja) * 2018-04-10 2018-08-09 株式会社ニコン バイオチップ及びバイオチップにおけるアライメントマークの検出方法
WO2019215650A1 (en) * 2018-05-08 2019-11-14 Lidong Qin Cell holding device for microinjection
JPWO2020054559A1 (ja) * 2018-09-10 2021-09-16 セントラル硝子株式会社 含フッ素樹脂組成物
CN109016275B (zh) * 2018-09-19 2024-01-30 中国科学院生态环境研究中心 微孔模具及其制备方法和应用
KR102170803B1 (ko) 2018-10-19 2020-10-27 주식회사 이지다이아텍 세포의 격리 및 형태학적 분석 방법
CN113490854A (zh) * 2019-03-01 2021-10-08 凸版印刷株式会社 微流体设备及试样分析方法
JP7281545B2 (ja) * 2019-07-02 2023-05-25 旭化成株式会社 バイオアッセイ用微細ウェルフィルム、バイオアッセイ用微細ウェルフィルム形成用感光性樹脂組成物、及び、バイオアッセイ用微細ウェルフィルムの製造方法
CN110596375B (zh) * 2019-10-17 2022-12-27 清华大学深圳国际研究生院 微孔板、基于微孔板的高灵敏度免疫荧光检测方法
KR102293714B1 (ko) * 2019-12-26 2021-08-26 울산과학기술원 소수성-친수성 표면을 갖는 마이크로웰 어레이 제조방법, 이에 의해 제조된 마이크로웰 어레이 및 소수성-친수성 표면을 갖는 마이크로웰 어레이의 미생물 현탁액 구획방법
KR102293716B1 (ko) * 2019-12-26 2021-08-26 울산과학기술원 양면성 구조를 가진 마이크로웰 어레이의 미생물 추출방법
KR102573402B1 (ko) * 2021-03-24 2023-09-04 재단법인대구경북과학기술원 액체생검 유래 생체물질 분석용 기판, 이의 제조방법 및 이를 이용한 분석방법
CN113866145A (zh) * 2021-09-26 2021-12-31 联合基因生物科技(上海)有限公司 一种快速聚合酶链式反应用硅基芯片的制造方法
CN114350514B (zh) * 2021-12-28 2024-01-05 上海前瞻创新研究院有限公司 一种多细胞链状培养装置及其在制备肝索结构中的应用
CN115198376A (zh) * 2022-05-18 2022-10-18 长春长光辰英生物科学仪器有限公司 微孔阵列芯片及其激光诱导向前转移的单细胞分选方法
CN118185744A (zh) * 2022-12-14 2024-06-14 成都今是科技有限公司 微孔阵列及其制备方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395348A (en) * 1981-11-23 1983-07-26 Ekc Technology, Inc. Photoresist stripping composition and method
IL68507A (en) 1982-05-10 1986-01-31 Univ Bar Ilan System and methods for cell selection
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
US5272081A (en) 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
EP0205387B1 (en) * 1985-06-11 1992-02-26 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Human monocytes cultured in suspension in serum-free medium
EP0258565A3 (en) * 1986-07-02 1989-05-24 E.I. Du Pont De Nemours And Company Location identifying means
JPH05240869A (ja) * 1992-02-28 1993-09-21 Suzuki Motor Corp 血液等の凝集パターン出力装置
US6410252B1 (en) * 1995-12-22 2002-06-25 Case Western Reserve University Methods for measuring T cell cytokines
US6156389A (en) * 1997-02-03 2000-12-05 Cytonix Corporation Hydrophobic coating compositions, articles coated with said compositions, and processes for manufacturing same
US6548263B1 (en) 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6893877B2 (en) * 1998-01-12 2005-05-17 Massachusetts Institute Of Technology Methods for screening substances in a microwell array
CA2318881A1 (en) 1998-02-04 1999-08-12 Tina Garyantes Virtual wells for use in high throughput screening assays
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6087103A (en) 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
WO1999047922A2 (en) * 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
JP4389039B2 (ja) * 1998-04-09 2009-12-24 株式会社リンフォテック アロジェニックな活性化ｃｄ４陽性細胞を主成分とする医薬組成物、およびその製造方法、ならびに該医薬組成物調製用キット
US20030027214A1 (en) 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
DE19935643A1 (de) * 1999-07-29 2001-02-01 Augustinus Bader Vorrichtung zum Züchten und/oder Behandeln von Zellen
US6541367B1 (en) * 2000-01-18 2003-04-01 Applied Materials, Inc. Very low dielectric constant plasma-enhanced CVD films
IL151287A0 (en) * 2000-02-24 2003-04-10 Xcyte Therapies Inc A method for stimulation and concentrating cells
US6734000B2 (en) * 2000-10-12 2004-05-11 Regents Of The University Of California Nanoporous silicon support containing macropores for use as a bioreactor
US7211209B2 (en) 2000-11-08 2007-05-01 Surface Logix, Inc. Method of making device for arraying biomolecules and for monitoring cell motility in real-time
WO2002055653A1 (fr) * 2001-01-09 2002-07-18 Matsushita Electric Industrial Co., Ltd. Dispositif de mesure du potentiel extracellulaire, procede permettant de mesurer le potentiel extracellulaire a l'aide dudit dispositif et appareil utilise pour cribler rapidement le medicament apporte par ce dernier
JP4755368B2 (ja) * 2001-07-24 2011-08-24 株式会社セルシード 高密度細胞アレイ用基板、製造法、及びその利用方法
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
JP4754746B2 (ja) 2001-09-28 2011-08-24 オリンパス株式会社 棒状担体およびこれを具備するシリンダー反応容器
EP2365331B1 (en) 2002-11-14 2015-11-04 Valneva Method to clone a single antigen-specfic lymphocyte.
JP3799392B2 (ja) 2003-03-28 2006-07-19 財団法人富山県新世紀産業機構 １個の抗原特異的ｂリンパ球を用いた抗原特異的抗体産生ハイブリドーマの作製方法及びモノクローナル抗体の製造方法
US20050112033A1 (en) * 2003-09-08 2005-05-26 Irm, Llc Multi-well containers, systems, and methods of using the same
US20050220675A1 (en) * 2003-09-19 2005-10-06 Reed Mark T High density plate filler
JP2006105803A (ja) * 2004-10-06 2006-04-20 Hitachi High-Technologies Corp 生体試料物質の分析方法、分析装置、マイクロアレイ及びイムノアッセイ

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CN102928584A (zh) 2013-02-13
US20080014631A1 (en) 2008-01-17
KR20060091318A (ko) 2006-08-18
WO2005069001A1 (ja) 2005-07-28
CA2544470A1 (en) 2005-07-28
EP2381255A1 (en) 2011-10-26
JPWO2005069001A1 (ja) 2007-07-26
EP1691196B1 (en) 2012-12-26
CN102928584B (zh) 2017-06-13
EP1691196A4 (en) 2007-07-11
EP1691196A1 (en) 2006-08-16
KR101111231B1 (ko) 2012-02-17
US20110195496A1 (en) 2011-08-11
US9310362B2 (en) 2016-04-12
ES2411104T3 (es) 2013-07-04
CA2544470C (en) 2012-02-21
JP4069171B2 (ja) 2008-04-02

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