DK2155907T3 - Genetiske varianter nyttige til risikovurdering af koronararteriesygdom og myokardieinfarkt - Google Patents
Genetiske varianter nyttige til risikovurdering af koronararteriesygdom og myokardieinfarkt Download PDFInfo
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- DK2155907T3 DK2155907T3 DK08751458.4T DK08751458T DK2155907T3 DK 2155907 T3 DK2155907 T3 DK 2155907T3 DK 08751458 T DK08751458 T DK 08751458T DK 2155907 T3 DK2155907 T3 DK 2155907T3
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- 239000011159 matrix material Substances 0.000 claims 4
- 150000002617 leukotrienes Chemical class 0.000 claims 3
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- 102000015689 E-Selectin Human genes 0.000 claims 1
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- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical group CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 claims 1
- GWNVDXQDILPJIG-NXOLIXFESA-N leukotriene C4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O GWNVDXQDILPJIG-NXOLIXFESA-N 0.000 claims 1
- YEESKJGWJFYOOK-IJHYULJSSA-N leukotriene D4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@H](N)C(=O)NCC(O)=O YEESKJGWJFYOOK-IJHYULJSSA-N 0.000 claims 1
- OTZRAYGBFWZKMX-JUDRUQEKSA-N leukotriene E4 Chemical compound CCCCCC=CCC=C\C=C\C=C\[C@@H](SC[C@H](N)C(O)=O)[C@@H](O)CCCC(O)=O OTZRAYGBFWZKMX-JUDRUQEKSA-N 0.000 claims 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Description
Table 2. Association results for the Icelandic discovery cohorts, and the replication cohorts. The columns in the table indicate (1) the cohort, (2) rs name of the marker in question, (3) the chromosome, (4) position of the marker in NCBI Build 34, (5) p-value of the association, (6) the Relative Risk of the association, (7) the number of Ml patients, (8) the frequency of the associating allele in patients, (9) the number of controls, (10) the frequency of the associating allele in controls, (11) the associating allele.
Example 2.
[0231] Further genome-wide genotyping of Icelandic patients diagnosed with coronary artery disease and/or myocardial infarction was performed. Recruitment and phenotyping was described above under Example, and all methods involved were as described in the above.
[0232] Descriptions of the additional replication cohorts are as follows:
Cohort from Italy: The subjects from Verona were enrolled into the Verona Heart Project, which is an ongoing study aimed at identifying new risk factors for coronary artery disease (CAD) and myocardial infarction (Ml) in a population of subjects with angiographic documentation of their coronary vessels. In brief, the CAD group had angiographically documented severe coronary atherosclerosis, the majority of them being candidates for coronary artery bypass grafting or percutaneous coronary intervention. Control subjects were selected such that they had normal coronary arteries, being submitted to coronary angiography for reasons other than CAD. Controls with history or clinical evidence of atherosclerosis in vascular districts beyond the coronary bed were excluded. Information on Ml diagnoses was gathered through medical records showing diagnostic electrocardiogram and enzyme changes, and/or the typical sequelae of Ml on ventricular angiography. The study was approved by local Ethical Committee. Informed consent was obtained from all the patients after a full explanation of the study.
Cohort from Johns Hopkins: The study group from Baltimore is comprised of The Johns Hopkins University Sibling and Family Heart Study, G-Cal, and GeneSTAR studies. The subjects consisted of families identified from 1983-2006 from probands with premature coronary disease event (before 60 years of age). Probands with documented CAD were identified at the time of hospitalization in any of the Baltimore area hospitals. Their apparently healthy siblings without CAD were recruited as well as adult offspring and spouses. Of probands, generally 24% had an Ml as their index event, 65% had a PCI and/or CABG, 8.4% had angina with angiography documented CAD and were treated medically, 1.7% had sudden cardiac death, and 1.7% had angiographic documented coronary stenosis with an abnormal stress test and no symptoms.
Cohort from WTCCC: This study cohort has been described previously (Nature 447:661-78 (2007)). Summary statistics from a genome-wide association study performed on these samples is publicly available at http://www.wtccc.org.uk/info/summary_stats.shtml.
[0233] Reanalysis of the markers presented in Table 1 was performed using the expanded dataset of 3,047 individuals diagnosed with coronary artery disease, 2,395 diagnosed with myocardial infarction, and 28,321 population controls. The results are presented in Table 3.
[0234] The top 100 markers in the scan were explored further by replication analysis in six cohorts from Durham (North Carolina, US), Philadelphia (Pennsylvania, US), Atlanta (Georgia, US), John Hopkins University (Maryland, US), Italy, and in a dataset from the Wellcom Trust Case Control Consortium (WTCCC; England). The replication cohorts combined comprise 6,108 cases and 19,396 controls. The results of the replication analysis is shown in Table 4A - 4H, both separately for each cohort and a combined analysis for all the replication cohorts, as well as a combined for all the cohorts, including the Icelandic discovery cohort. Many of the variants discovered in the Icelandic discovery cohort show overall significant association in the combined replication groups. The effects are modest, which explains why some cohorts do not indicate significant association, while other cohorts do so.
[0235] In the combined analysis of all the groups (9,155 cases; 47,717 controls; Table 4H), marker rs11751605 stands out as the most significant, with a combined P-value of 1.16 x 10'8. This is a highly significant number, and in fact represents statistical significance at the genome-wide level, after applying the conservative Bonferroni correction for the number of statistical tests performed (approx. 300,000 in the combined analysis). It should be noted that the number of tests performed in the replication effort is much smaller; consequently, the correction to be applied to correct for the number of tests is smaller, or 100 (giving P-values of 0.05/100, or about 0.0005 as significant after correction). Several markers meet this threshold of significance.
Table 3. Association results for SNPs showing association to myoardial infarction (Ml) and coronary artery disease (CAD). The results are based on a genomic scan using 2,395 Ml samples, 3,047 CAD samples, and 28,321 controls. The columns indicate (1) chromosome, (2) position in NCBI Build 36, (3) the associating allele (4), rs name of the SNP, (5) frequency of the associating allele in controls, (6) the number of controls, (7), the p-value for association to Ml, (8) the Relative Risk of association to Ml, (9) the frequency of the associating allele in Ml patients, (10) the number of Ml patients, (11) the p-value of association to CAD, (12) the Relative Risk of association to CAD, (13) the frequency of the associating allele in CAD patients, (14) the number of CAD patients.
Table 4. Results of replication analysis in several populations. A total of 100 markers from . the genome-wide scar» shown in Table 3 were selected for replication. The table shows results of replication in cohorts from Atlanta and Durham (A - MI; B - CAD), Durham and Italy (C -MI; D - CAD), John Hopkins, WTCCC and in combined replication samples (E - MI; F - CAD), and results for the Icelandic discovery cohort and combined analysis for all the cohorts (G -MI; H - CAD). The number of controls/cases is shown for each analysis.
Table 5. Surrogate markers for marker rs11751605. The markers were selected from the Caucasian data set of the HapMap sample (CEU; see http://www.hapmap.org), using a cutoff of r2 of 0.2. The search was done in a 2Mb interval flanking the rs11751605 marker. The table shows (1) chromosome; (2) SNP rs name; (3) position in NCBI build 36; (4) value for D' to rs11751605; (5) value for r2 to rs11751605; (6) P-value of the association with rs11751605.
SEQUENCE LISTING
[0236] <110> deCODE Genetics ehf
<120> GENETIC VARIANTS USEFUL FOR RISK ASSESSMENT OF CORONARY ARTERY DISEASE AND MYOCARDIAL INFARCTION <130> 2511-PC00 <160>172 <210> 1 <211 >599 <212> DNA <213> Flomo sapiens <400> 1 caactcaaca gcagagtgaa atgcgatgcg atcaggtttg tcgatggcat ttcacaaact 60 tacagaagga agtctcttta gaggagaaca gcaattgagc acaggtgccc tggtgtagaa 120 aggagatgag gaagcaaaac atgcaggcag atgggtctgt gtcctatgtg ttcttcctaa 180 gagacaccca agcaaactga acttacgaat tgcatgttcc actgaaacga tacccaaaat 240 gtccaggttc tgtgggttcg gactgattac tcttcattta tggggatcac aacccataay 300 ttgttcatgt gtttgtgaat agatgaatag cctcggcatt gaattcaatg attcacaaaa 360 gtgtaaaaaa aaatctgtgc ctgtgataga ctgtaggtaa gtttgctctt gtcctccctc 420 actgcaaagt gtcacatttc taaaaacttc cctttctttt catctgacag tgagacaatg 480 gatatccata gaaaccctca gagcatcttc aatattttcc aaaagtattg gaacttggtg 540 caaatcactg tgcctacaga ttttgatgga actgcccaga tcaagaaaaa gatttgtat 599 <210> 2 <211 >599
<212> DNA <213> Homo sapiens <400> 2 ctcaggctct acatggcctg gggtgcgtat ctgaggacac tggtgggttg agtccccoca 60 gttgctggaa gcggggtagc agtcaetaca cccaaaagaa ggtacagagg gcagacacaa 120 agggcaaagg ttccactgcc ctgggcagtg ccatgagggg ctggcagggt aggggttgac 180 tggctctcag tctgagctcc ccagatatcc cacacacacc tcctcaaagg agggcaaggc 240 caagccaatc acaccccact ttgatccctg cccctgggcc aggccgtcct gcgggatggk 300 aggggataac atttctcaaa gactgttctg cgcaatctca agcgttcagg ggacaaataa 360 gggtagaaac tggcaaattc actccactac cctacgggag attcagaata catttaagag 420 aattaaaggt cctgacaagt cctgtagaaa agaaactgtt tagtgtttcc cagcctgatc 480 tgaccgtgga aatctttttt ttaaatgact gccaataatg tcccacccac caggaaaaca 540 cctgctggga aaagctgatg tggaaagatg ctgctcactg gaaggccacg aacatggta 599 <210> 3 <211 >599
<212> DNA <213> Homo sapiens <400> 3 ctaaatctgt tcatagcatt tggtcctcat gttctttctc tattctgaga ggccctccct 60 gtaggggatc actgatgtgt atgtcatacc tgctatgagc taacctcagt ggggagtctt 120 caaggaagtc tacagtgaac aactcagttc tctaaaggaa ttgtgatttt cctaagaact 180 gcataggcgc tttcctgatg gtttgcattt ccacattcta aaacagagca tggacagagg 240 ctctttactg tccttcactc ctattcaaga gcaaggttgt tgccactggt gttatttccr 300 gtgtttaaag gcaaatagat aaaaagaatg gagaaggcct ttcacaccca aagtgaaacg 360 cgtcctcttc tcatgcatcc cgcttcccct cctgacttcc tcctctatta ttaatagcac 420 cagcatcctc ctaatgacct agcctggaat ctgcagaatc attcttgac.c acgggtcctc 480 tctaggccac ccacgttaaa ttgcttcagt tcatcttttt cttctgtttc cctgaccacc 540 agcctacatt aggctcttgt taccacttaa ctgggcgcct gaaataagct cagcagctg 599 <210> 4 <211 >599 <212> DNA <213> Flomo sapiens <400>4 tatcaactaa atgaatactg gttctagtca aactgtcctg gataattgca cctattttcc 60 tctttgttca tgttgttaac ttgaaatgtt ctgactggtg aataatcaac cagcatttat 120 acatgttatg tggctgctgc acttcacaga tagaaaactt gaaatctatt acctaagtaa 180 taacggcttg aaccatctta gtgggtttct cagataagaa gacttcaagt attcactgga 240 ctgtattcat tttcatgtga acattataga tgagatttta gcccttatta ttgatttagk 300 attgttccfca tctgcataaa gtgccttttt tctcttcttg cataaagtta ttctagcctc 360 agggtaatga ggacatttct ctccaggagg tagaatatga tgtggcaaat gtatctgcat 420 atccagaaat gctttataaa gcagctgctt gctctgagca ctcattgtgg tggaagccaa 480 gttaaatgag gtgtgctata atgtaatagc atttttattt gttaacaaac aagaaattta 540 catacctcat gcaagccttt ctctcttggc atttaacccg catttaattt atatatata 599 <210> 5 <211 >599 <212> DNA <213> Homo sapiens <400>5 ctggggccag aataagattt tattactctt ttatagagct tttaaattac tataagtgct 60 tcttgtttca tagaagatga atactctagc aaaataaagt tctcattacc tggctggagg 120 aaagatacat atttaaacat ttaataattg ccagatacac tataattaca cttttaattc 180 taacagaata atacaaaagt tctacaaatg ataatgtgat atgccacaga aaataagttt 240 aatatgtaca gaaggatacc tcatgatgtt tgtttctttt tgcaatctca cttggcatck 300 ttccatcttt ggtttgtagc attttattag ctccaagttc aagcaacttc aaaactatat 360 ttttatgacc ctgacgtgct gcccacgtta aagcctgtaa gtagggggaa aagaagattg 420 tttaaagaga aggagtgtat atgagacaga caggaaaagt tttcaacagt atttatgaca 480 caataaaaaa gagaacatag ttaattaatg gaatgatgca atctcttcat tttacaatat 540 aatgtaaaca tatttccaaa gttgtaattg caaagctgac tgcaaagctc attgatttt 599 <210> 6 <211 >599 <212> DNA <213> Homo sapiens <400>6 atcttttttc agaatctgta ctatgcatct aatatatacg tggcactttg cttggtcctg 60 ggggtacaaa gctgagtcag attgttacaa agtctaaata actgagataa aggtgttaat 120 acagcccaga aaagcacact taattcagcc tggaaggttt tttttccccc ctccttcgag 180 attttcagag tatctccttc ttagtaagaa ttgcttggct tagtatgttg agaaaaacat 240 actaagtatg tagtgttgtg ttggaaggaa aacttaactg ggtgagattt tcagctgagk 300 agctttagct gttactctca tggaccttcc tctgggcggt tgatacaggt tctgtaggaa 360 aaccgctgaa tgaaagcagc tcctgcagat gctattctgt tttcaattgt ggtaattcct 420 ttaatttttt ccctttcaat ttactcctta ttctctagta ataatggact tttgggaggt 480 tgcatttatg ataaaaaata gcctggggct gtacaatcct tcctatcatg aagaagtaca 540 aagttgtaag tagaagcagt ggccttgctt tgccaatgca cactgaaggg gataacgtt 599 <210>7 <211 >599 <212> DNA <213> Homo sapiens <400> 7 tattctaaat gttaatatca aaaatattat tttcaattca ccccaggcac agagaactaa 60 gtattattat tgctattgca ccggcattcc ccaatgagac agtgattttc ttttaagaca 120 tttttaaata atataggcag aattaagtag acggtgatct ggtaagtaga tgtttcaggg 180 taacagctgt gcaatgctcc atgcagggaa ttagattgtc attttattcc ttaccaggaa 240 catacattca gttaaacaat tatttgactt ctgctcttcc actgatttct aagttgaggy 300 tctctcttgt gcctgtctga tcagataagt agagttgtgc cttggtttat agatgagata 360 aatgtgtatt tgaataagca taagttaaag aaattttaaa atcccttagg aagctaggct 420 tatcagagaa atccaaggaa atacattaac aaactaggaa tttgttctaa caggttaatt 480 ataactcata aacttattgg gtttttttac cttttaattt tatattacat ttgcttataa 540 taaggaatat tgctaggaat aaaatttttt aatattctac aattaacaat tatctcaat 599 <210> 8 <211 >599 <212> DNA <213> Homo sapiens <400> 8 atcctgaaca actgaataga agtcagggcc taccttgaac cagtcagaaa atgcattcca 60 gaggagatgc ttttgaatca cacgtacaag tcccagaaaa cttctctaca acctttacct 120 ttgtccttta ggtggaacaa agtactatat aaaactgtgt ggggattatt ttgatgaggg 180 ttgaaaaatg aaggctctta tccgttattt aaattcctgt gtgcaccgcc cccttcacaa 240 agtgtgggag taggtcttct acatcaagat gcctggagtt tggttcagtg aaaaccttty 300 ggagggcctg gggatcttga ttgtccctca gtgccctgat gaaatgtttt tatttatcct 360 gcttgctgcc tggagttgac actggtaata tcaatcattc cctgccagcg tattaacatg 420 gctgcacctg cttaaaccat ccacatgttg taactcacaa gaagttggga atcaaatgca 480 gtattattta tgtactccct taacttgtcc catactacaa aaatttccac tctgacacca 540 tctgctaggg aaagggattt atctatcgat gtgaaacacc cactgaaccg gtatcacat 599 <210> 9 <211 >599 <212> DNA <213> Homo sapiens <400> 9 cctgggtccc tctgacggca tactcttcct ctgcgcagag ttcatcccga agacacggag 60 caccccgcgg cctacagcgc gggcgcccac gcgggcgccc cgccgagggc gccccacggc 120 cgctcccccc gcgccaaccc cgcggccagc gcggcccacc cagcagccag ggagccggag 180 gggcggcggg cggcggcggg ggcggctgaa ctcggcgagc cgggcgttcc gggatggcga 240 ggtgcgcctg gtgcggcccg cgggcctgag ctctggcagc gggcgcgtgg aggtgttcgy 300 gggcggacgc tggggcaccg tgtgcgacga ctcctggaac atcagcggcg ccgccgtcgt 360 gtgtcgccag ctggggtttg cctacgccgt gcgcgccgtc aagagagccg agttcggcca 420 gggcggctcg ctgcccattc tgctggacga tgtgcgctgc gcgggctggg agcggaacct 480 gctggagtgc cagcacaacg gcgtgggcac ccacaactgc gagcacgacg aggatgcggg 540 cgtcgtgtgc agccaccaga accccgacct gtaggcaaca cgccgctgcc ccaggccat 599 <210> 10 <211 >599 <212> DNA <213> Homo sapiens <400> 10 gaggtgagag gatcatttga gcacaggagt tcaaagctgc agtgagctaa gaaggtgcca 60 ctgcatgggt gatagagcaa gaccccatct cttataaaca aacaaacaaa caattttttt 120 tatcccctag ttctttaata gatcatttat gttttctttt ctcctgtcct ttcccctttt 180 ttcctattct ttcttcctcc ttcccgaggt atggaaggat tgtgaatcta ctcagtcaat 240 cttaaaaggg gcaatgggga gagggaaaac aaggaaccct cacaggctaa tttttaaacy 300 acatctctta agaaaatatg gagaagcaaa gagaggaaaa tgtaaattac ctgaaattct 360 accactgtaa atatgttgat atactttcag actttttcct atgcatttat aacacacaca 420 cacacacaca catatataag ttgcaaaaaa tggccaacag tatatatata catactcttt 480 tgtagtcccc tttaagcaac ttattgtgaa tgtctttccc tctcaagctt tatactgaca 540 acatcatttt gaaaagctac atgactttcc attgtgtgaa tgtactatca tttatgaac 599 <210> 11 <211 >599 <212> DNA <213> Homo sapiens <400> 11 ctgtggacaa atattgattg tggcacacat aaagacagtt ttgtaagtgt gagtggtgag 60 aaaacatttt aaaatatcaa tcgtccagag aagattagaa aatttgcaca ctttatgaat 120 ggttccaata acccgcagat tgtctcatat tagacttcct cctgagctga tctccagtca 180 tataagagtg catattgcta tcaccgcttg acaaactggt gtaaaaatta aggaaacata 240 acttttcctt gtagcatctt aagaataaca agttgtcctt gacagtaata aagaaataay 300 gcagggaatt cagaagaaaa ctatttcaag ggagtcatag aataaaagcc agagtaatga 360 gtttggtgac aacaacactg agacaagaga aagaatagaa actgctttaa aaaatttgca 420 aaatctactg atcgcagtga tccttctctt ttttgttgac atacttaaga ataaatttta 480 gaataaaaaa attctggaag atatctctgg tgacttaaat gttctagata caaagctggt 540 cgctcatggt agttggatga tgtgttcatt tctacttttc atttgaatgt gacttagag 599 <210> 12 <211 >599 <212> DNA <213> Homo sapiens <400> 12 acataatatt ttactctata aaaattaatg attcttctct cactttagtg tctgtgtgcc 60 gatgcctccg taggaaaaat tgaataaata cgcaccaaag tgagaaatga gttgtattaa 120 atttatactg aagtgcgtgg tcatcttagt aattctagaa ctttccataa actattttat 180 gaaatgcatc aacgtttcta ttttagtgtc aagacaccag aaaaaattaa aaatgåttct 240 actgtattta gtcctacgat agatcacacg actattcatc gaagtgaaaa tactggtgcy 300 aacaaaagcc aacctttcaa gaaataatct gcctacagtg tttgatccag tatctataca 360 cataaaacca gctgcaagat aagcaataca atttaaaaca gttgttacaa tttcaagtga 420 aattggttgc ttccaataag acttcctttt atatagaggg gaaactcaca gtgtggcaat 480 aaattcatat tcatttaaat tagtgcctaa atataatgtg ggtggtctcc caagcactcc 540 ttggtgaatt attggctaag aggtgtttag aaagtctggg agggtgggta gtgatcatg 599 <210> 13 <211 >599 <212> DNA <213> Homo sapiens <400> 13 ctcaacctcc ttgttgaagg catcccggcc tttttggttc tggagcctcc acctgcctcc 60 taatgctccc ctaagtcagt tagcacagcc cccgaccctg caccacctcg cagttgttgc 120 tggtgtgcgg ttctcgccgg agttcttagt gcttcacggt tatcttttgc tgggattgtt 180 gaaagttaac ctcccgttaa ttcccaaagt gttactttta ctgctatact ttaaaatttc 240 ttcatttgcc actttttagg tttgtggtcc cgggcaagtt taatttcttt tcaggattcy 300 catttgtata atgaggacaa cagctgttgg ttcaggattg tgaagcttca atgagataat 360 tgtttagcat gtttttattc catcatgaac accatttgta ttgtgtttta cagtttacaa 420 agtgctgtca caggtgttac ttcatacctt aacactactc ctgtccagtg aatattagta 480 gcctcatctt gttgagaaga ctgaggccaa gaggtggatt gactaggcaa agtcaacaca 540 gtatgttagg tagaactcca acctaaacag ctattcttga ccctaggttg accatatgg 599 <210> 14 <211 >599 <212> DNA <213> Homo sapiens <400> 14 ctggtgatag agtctttagc cagagccctg gatgagatca cctaggaaga aaagggggat 60 ggcaaagaac atagattgag cagtgaccat gaagtcacct gtcaataaat gcagaaccct 120 cataacttgg tcaaaagcag ttttggtgat aggtttgagt gtgtttgagt gcgttgagaa 180 gcaaatgtga ggtgaggaat gggaaacaag tgtgtgtgtc tctttcagta aattttatgg 240 aaagagaaga agagaaatgg agccaaaggc agagaataat tcagtaagat aaaagatcty 300 gtagcatatt tgtgtgttga tgggaatgac ccaacacaga gaaggaaaat gtggtgtgtg 360 tgtgtgtgtg tttattgggt gtcaggggga cagaggaagt agcaggcaca actttgattt 420 cacaattctg tgctggaaga gagataatag ttagagatag tggatattct gtaggctatt 480 tgaatagcta tgtagtctaa tgtgggtaac ataactggca aatatttatt cattgaaaac 540 tgtatgccta ggtacaactt taaaagatta cagtctactt gggaaaacat ataatttct 599 <210> 15 <211 >599 <212> DNA <213> Homo sapiens <400> 15 tctctttatc ttttatctcc cttacctaat ccttcttctt caacaaaatc tgtttattca 60 cactttattt atgatagtct ttttgccttc atgacttcct tccaagatat acccgtccaa 120 tttattcaaa tactacccat ctttagctta ttacatttct tctattattc tttgaaactg 180 ttgtaatccc atattttact tgagttttca caggagtgca tgaagtggtg gtggctgtgt 240 taattctttt acaaccacat tgtaattttt ctgaatgtag ggaccatgtc ttggacttcy 300 ttatactgag cacgtaggtc tataaaagat aattgcttgc ttgaatcacc ttcagttcat 360 tcatgcaaca acatttaatg agcaattact ttgtgctagc aggttaaata taatacttct 420 gaaaaaaaag tttttcaaaa ttatttactc ttcctaaaac ttacatgtca ataccttaga 480 gaaaaaaggc catttctctt ttcacctctc tttttgtaac tttgcacagt taaactctgt 540 ctcactcacc tggctcacta gtgactcaga gattttgctt gggtcccaaa tctaagatc 599 <210> 16 <211 >599 <212> DNA <213> Homo sapiens <400> 16 cacagaggca acttgcctca gagtatatga tgccttggct ggggatgggg tagtagacct 60 agttcccagg ccatcccaac ttggacccac gagatgtccc ctgccccagt ccggctctca 120 gggttttttg tactgtgtca aaggatgtag agggcttcac tttccctgga aatgtgcttt 180 agattgcttt ttgggggaat cttgcaaact gggatgtttg gacttctctc ctgccctatg 240 ctgaatttgg agggagccat tttctgtctg ggaaatgctt tagatcttgg agccactggr 300 gatgttgaag aattgaaaaa ggccaggtgg ggaccctcag gtacccacag tgcttctccc 360 cggtgaggag gcaccagtga ggaagtgggg tctgatatct ggtgttacct gagaaaaagg 420 tgggacggaa aaagaagagc cttctaactg gtccagtaag gccactctgg gacaaatcac 480 agagtcatcc aaggtggcag ttatcttagc tataaggtgg ttttcagtgg gaacttttca 540 ctgaggacct tcgttggttg ccagcagtgg aagttcaagc tctttcctgc cctgttgta 599 <210> 17 <211 >599 <212> DNA <213> Homo sapiens <400> 17 taaacctatc gcgtgccagg tactggttag gtgctctaaa tggtgatttg tttgttttct 60 ctaaaacaaa cagggccttg ctatgttgcc caggctggtc ttgaactcct ggtctcaagc 120 aatcctccaa ecteagcctc taaagtcaat aagattatag gcgtgagcca ctgcatctgg 180 ctaaatggtg ataataataa cactaactgg cattggttca gggcctacta tgtgccatgc 240 actgcttaag ccttcactca tcggatcccc acaattccaa gaagctgctt ttagtactgy 300 tccctttaca ttgttaagaa cctgaaggtt cttggacttg tccaaggtca tacagtaggg 360 ctgcttgtta agacccctga tcccagcctt ctagctgcag ggagcacagg gaccccagag 420 cctggcaggg gcagcatgca gaggcaaggc ctgctgggag acaggtgcag ggacggggag 480 tcagttagga aaggagctca aacagggttc ggggtaggcc acaaattccc cctaggggga 540 tggaccccca gccccgtccc acctcccaca agccccaacc cagcagggga cccacacct 599 <210> 18 <211 >599 <212> DNA <213> Homo sapiens <400> 18 gtgtatatat gagtggtatg agggcgaatt atttttgttt tctttttaat gatctcttaa 60 attttccaga atgtctacaa tgaccttgta ttacttttct aatcagaaaa aaagaaaaaa 120 gttaccgaag aagagataag tgaagcacac acaaaaggca gaatatatag tgcatcaaga 180 atgtgtgttt tataatctga cagacctagt tagaccatag tccatatttc aaatataatt 240 acatgtgctc atagctgaga accttctcct gggatggatg catttcacca ggtcactgcy 300 gaaatgttgt acttttatgg atggtgatga ggaagcatct gttttaggtg tggtatttcc 360 tggaggcaga aaactgcttg agttagctca ttcagttttt cagtggcctt tctaatgcat 420 gttttgtttt gttttaatgc tttgcaaaag attcctagag tggaaattgc ctttgcaaaa 480 attataacag tgagaaaatt atgacagtga aagggatctg ccctaactgt ccccatcttg 540 cttctgggta tctttgctca ttcctgggtg tgggccaagc taactttggg agaaattta 599 <210> 19 <211 >599 <212> DNA <213> Homo sapiens <400> 19 agcctggctg ttttcatttc caaagacagg gctggtttcc ttaggagcag atgggtccta 60 tccatctctt catccctgca tccccactac actgtgggcc tgtggacatg gctgtatctc 120 actgtggtcc aggactcggc aagggttgga atcctggctc tggaggacct gaggctgctc 180 agtaagtgtt ctaagcgttc atgtctgcat ttgtagaaag agagtagaat aataatactt 240 gtgttgtaaa gttgttgaag cattcagtaa gctaatctac tcaaaactct gtgaatgggk 300 cctggagtta agtaagcact cagctaacat catctgccat catggtggtg ggcgactaag 360 acggcatccc caggtgactc catattcaat gccattgtct acacttcccc acaggcacct 420 gatcaggtaa cacgccaggc attagcattc attcaaacag cactgagact ctgaaaggtt 480 acatggcgtg ctccaggtga gccgcttgac aggggatgag cttttacctc caaacccacc 540 ccttctaccc agaaagaggg tgcgttccca gtggccggga ggatgggagg gtggaggtg 599 <210> 20 <211 >599 <212> DNA <213> Homo sapiens <400> 20 gttttatggt gcatatgtta cacatcataa cctttttcaa gtctctttta gataacaggt 60 aggatacaat aaaagggcag acatatttat ttaagatcaa ggaggtaagt tgttatttta 120 ctaaaactta acagaaattg acaaatactt ttatatgtct tgaaaaagtg cttaaagcca 180 catttcatca aataaaatag attttatttt agcttaccta ttggtaattt tcagggctct 240 gaaaaggctt taattaaaga gtatcagagg atttaagagc aggatggctg tttgtgtcar 300 tattaagcca agatttacaa aggcctatta cggttccagt gacatttcct tcctattttt 360 ccatatcagc aggaacattt cttgagggaa tagattgcta cttgctgata agatctctga 420 cagtaaaggt aggctaagca ggatgccagg tatgaaacta gagaataaaa tcttatcaaa 480 tgtaaaactt gtaacattgc acctgccatg tagttggttt acctcgaatg gtcattgctt 540 ttcctcaaaa gcatataaag ttgtatccta ataagtgttg gtatgcaaca aaattatgt 599 <210> 21 <211 >599 <212> DNA <213> Homo sapiens <400> 21 ccccagacaa gtgcccgtat acccagaact ttgtatttaa tttcatgggg ttcatgaagc 60 ctctgaaact cagcttaaga gtccatacca accaaggtcc ttataggaag agcttgtgtt 120 tttgttttgt tttggctttc tgcagtctct taataatgtt tattgaatga gagaatttaa 180 ctaatttccg gtttccataa tcactttaaa ctcggtattt gatttccttt tccctgggac 240 ctgtgacagt gccagcttca tagcctagtc taggcatgcc agttgcccac tgtggcaatm 300 aatatctgag cctgtggttt ttgccttagg taaactgtag agatggactc atggaatgct 360 tggaaaattt ttcagtttat gataatgtgt aaatgtcgag agccaattat tgaggaatgg 420 cacctcaaag tatttgggta ctctagatca gacatgacca tcttggtgtg tgaaattttg 480 ctaatgcatc tttcctaata gaatatacaa tctcagggct agaaagtctt agagatcatt 540 taatttaatt cctccagatt gattaagtgg tttgtccaag gtcattcaac tggtatagt 599 <210> 22 <211 >599 <212> DNA <213> Homo sapiens <400> 22 ccactgtgaa aactccttga aatcatgtag acaaatgaaa gctaaacatc aaataaataa 60 cctaaactgg taatactccc atttggctct ccttgtgtct tttcatgtgg gttagctctt 120 caaccagatt cagcatataa attgagtatg tatggttata tggtgacttt caaaagtaaa 180 tactttttct gtggaacaaa agagatggat ttgtggtttt ccaggattcc ttttccctga 240 cttggtagaa agatagccag gcatagctca gcagacctga aaataggtga gctgtcaagk 300 tgttggcagg gagaggctcc tctgggtggg acttggggca tcctaccagc gaaaaagaga 360 ctaagtttaa gtgatttcac atttgggctt tacttactat aattgctgaa gtgctaaatt 420 gagtgtgaca aatctaacag gtaattgcca agtaggtttc attaccagtc attgcataga 480 taaatgatgt tccttatgtt aaaaaataaa accaaactaa agaaaaaaaa ttggactata 540 tttggaggta gaattcagat attgcagata tgttcatata catcaaagct gtttcaatg 599 <210> 23 <211 >599 <212> DNA <213> Homo sapiens <400> 23 cactgaggct ctaaggcgcg gttctgggct cctttccagg gaaactctag gcctctcctg 60 tgctcatgct gcctctcaag tggctcctgc atcctccaca ctaaccggtt tcacaagttt 120 ttttttgagc attcttctcc ctcctccaca gccagtttag agctttcttg atcaaatcgc 180 ctaacctccg ggcgaacacg ttcttccctt tcctcgggca gggcacccca tcccagccaa 240 ggagccacca tcccactatc ttcagtcact cccagctggg ttacccgtct catgtgggcy 300 tgtttgtagt cagttctgcc tagggttggc agatttcgat taaacctccc actaggtcca 360 ctctcttctg agatctggcc ttccagaagg cacacttggg tctttgaaca ggaatggaag 420 gtgattaggg ttgtcccggg gttggcagaa gcgcttgggg ctacaccagt gtggggccga 480 aacagctcta agcacctccc actgccccac cacagatcca agtttgagca agaaagactt 540 ctgtgtcctc cctgaactcc atctcctccg ctctgcccac agagactgga cctggcttg 599 <210> 24 <211 >599
<212> DNA <213> Homo sapiens <400> 24 ccccctcctt cgagattttc agagtatctc cttcttagta agaattgctt ggcttagtat 60 gttgagaaaa acatactaag tatgtagtgt tgtgttggaa ggaaaactta actgggtgag 120 attttcagct gagtagcttt agctgttact ctcatggacc ttcctctggg cggttgatac 180 aggttctgta ggaaaaccgc tgaatgaaag cagctcctgc agatgctatt ctgttttcaa 240 ttgtggtaat tcctttaatt ttttcccttt caatttactc cttattctct agtaataatr 300 gacttttggg aggttgcatt tatgataaaa aatagcctgg ggctgtacaa tccttcctat 360 catgaagaag tacaaagttg taagtagaag cagtggcctt gctttgccaa tgcacactga 420 aggggataac gtttgctcct gttcagagtt cacggtcggg cgcggtggct cacgcctgta 480 atcctagcac ttttggaggc cgaggccggc ggatcacgag gtcaggagat cgagaccatc 540 ctggctaaca cggtgaaacc ctgtttctac taaaaataca aaaacaaaat tagccaggc 599 <210> 25 <211 >599 <212> DNA <213> Homo sapiens <400> 25 cttataacag tccagttaaa gttgttcaac tttgcaaggg gcaaaaggca agtttaatac 60 cctttaccaa ggtattaagt atatttttga tgtacaatat tttcaactta caatgggttt 120 gttggatgtg accccactgt aggccaattg tactttggaa gcccactgag acctactgca 180 acccccagtg agtgacagaa ggggtgaaac aaatgattta ccattaatag cagagagatc 240 caggtcaggt ggagctgtgc catgcccttc cagcaacgtg gactgcaggt caccctttcy 300 gaccccactg ctatctgctg ttaagaaaag aatccccgaa agtcagcaca gtcaagagac 360 actctccatt caagccagga aacgcaggcc gtgtttttga acaataccac ttgcttctaa 420 aagcccaatt tcgtccaagg tggaaaggct aaaaaaaaaa aaaaaaaaaa aacctgtgga 480 aattcccagc catcaccttg actctatttt taaagtacca ctagaagaca gagacattct 540 gtataaccaa agagacgcaa ataggccttt ctgctagttc acaagatgct acaggtggg 599 <210> 26 <211 >599 <212> DNA <213> Homo sapiens <400> 26 ccctaatgtg aagaaagacc ttaagggaga ctctttgatc cttaggtatt tgggactgac 60 tcagagcact gcacagaagt cactatcgcc cccttttcaa atctccatag gcaccgtttt 120 ctggatggtt ctctttaggg cagctttgac ctctgtgttc cgcaggctgt agatgatggg 180 gttgaggatg ggggtgacca cagcatagaa gagggacacc agagggtcag tggccggatc 240 gtagctggcc ttagggcgaa tatagataaa gagtgcggtg ccatagaaga gggagaccah 300 gatcaggtgg gaggagcagg tggagaaggc cttgcggcgg cccgcaacag atgggatccg 360 gaagatggta acgaggatac gcccgtagga gcccaggatg aggccaaagg ggcagaggat 420 gaggagggct gttgccagga taatctgcag ttcattaagc gaggtgtctc cacataccag 480 ctgcaggaca ggctggatct cacagaagaa ctgcgggatg gtattggggc cgcagaaggg 540 caaagagaag atgaaagggg tgtggcccag ccccaccagc accccacagg cccacgccg 599 <210> 27 <211 >599 <212> DNA <213> Homo sapiens <400> 27 tcacacttgg cacagacaaa gtgctgcaag gacaaagggc gggccgggtg gcatcagggc 60 tagagcggtg accccgaggg acagtggtga cccggggaca acagtgaccc caggagccag 120 tgactccagg ggaccacagt ggccccagga ggcagcagtg acagaagggg acagaaagca 180 gagtctgggc aggtgcaggc ctttcaggat tcacactggg cagaggggac tgacacctct 240 gtgaatgccc tggggtcagc agaccctacc cctcctctaa ggcactgatg gtaaccttgy 300 gagtcaccat cccctcccag tctggcctcc ccctcggcag cctcagcccc,aggagtcagg 360 tgccagcctg gtgctgcggc atggtgggcc ctcataggca gaggcggccc tgcctgtcca 420 cgtggggcct cctgcaggca ccccctgcaa gcctgggatc actgagcagc accttgcatt 480 cccccaggga tctgcatgtg aggatgaggg ctgggggctg gggcctgcat cagggcagga 540 ccgcatggcc tcccacccaa gccgccaccc aaggcacagc ttccggacac agcgctggc 599 <210> 28 <211 >599 <212> DNA <213> Homo sapiens <400> 28 ctttgggagg ctgaggcagg tggatcactt gagatcagga gtttgagacc agcctggcca 60 acatggtgaa accccatctc tactaaaaat acaaaaattg gctgggtgtg gtggtgggca 120 cctgtaatcc ctgctactca ggagactaag gcaggagaat cacttaaacc caggaggtgg 180 aggtggcagt gagctgagat cacgccactg tactccagcc tgggtgacag aatgagactc 240 tgtctccaaa aataaataat taaaaatgct atgaaaacca agcaaaacac attgatgggr 300 ggaatcataa ctgtgaccat ccattggtgt cccctaccat ggattaatga acaaacaagg 360 gcagagggaa aaataccctg cacatctgtt ggtagaaagc aaaaggtaca attaatgggt 420 tatttccctg aggcacagcc ttacttgcac caatgaatgt ttactggttg aaaatttgtc 480 agtggcagag cttatataca tctcatccta tcatatgaac gcatatagca tgtgacatgt 540 aggctgagac ataaaggatg aagaagtatt tacatgagtg agaacagtga cgcaaggac 599 <210> 29 <211 >599 <212> DNA <213> Homo sapiens <400> 29 gctagggaga cagacactca gcaaataact gcttaaaaca taaaatatat gagacaggga 60 aaagtacact ggagagaaat aaagcagtgg acggggtagg ggctctgatg ggatggagag 120 gggctgcgtt tttaaatggg gagcttcctg agtgggtgaa attgtagggg agacttggag 180 gaggtgaggg gtttggccaa gcaggtgcct gaaggataag tgctcctgag ggaaggaaca 240 gaaggtgcaa aggccctggc aggagcgtgc ctgtgtgctg cggggcaggg aggagccacy 300 gtggctggag gagggtcggg gaggggaggt cctgggctca catgtacaca tgtacgcatg 360 tattcgttca ttaatttgac gtctacctag ccctaccagg ggccaggctc tgagtatctg 420 tacctcccac cccgaccctg cccaacacag aggcctggga gggggtggcc cacctgaaac 480 acgatcctgg atttctcaag caggtactgg gaggttatgg caccagagat cacgcccctg 540 gggtggggag cacagtcagc tctcagtgag ggtaggaggg ctggtgttgg ctccgaggg 599 <210> 30 <211 >599 <212> DNA <213> Homo sapiens <400> 30 acagcgaagg gatggcgccg tgagccctca gcgcggggag acacacgccg ggccggggcg 60 ccaggagcgg gggtggcggg gaggggaggg agggaaggct ggtgacgtca gtggttccag 120 ttccgcagca gcggaggccg cggccgggga cgtgagacac cagctgacgc ccggagcctc 180 acaacctctg cacacacatt ctcctgaggg ccggtgcctg gaaacaaagg ccacccccgc 240 cggccggaaa cttctaggct ggcaatggag atgggacatc tggtgacccc ctctgtatcy 300 tcctctccct tggggtcctc caggaagggc tgcgtgatca atgacccact tttttgtttt 360 gtttttgaga tggcctcttg ttctgtctcc caggctgggg tgcagtggtg tgacctaggt 420 tcactgcaac ctccacctcc cgggttcaag cgattctcct gccccagcct ccctcgtagc 480 tgggactgca ggtgcgtgcc accgcgcccg gctaattttt tttttttttt ttgagacggg 540 gcctccctct gtcgcccagg ctggagtgca gtggcgctat ctcagctcac tgtaaactc 599 <210> 31 <211 >599
<212> DNA <213> Homo sapiens <400> 31 taacataaaa tttactggct ttctcatttt tgatttctct aaagtcttac tatttaaagc 60 aaaaataata acagattttg tgtctaaagc atatgtaaaa ttgtagtgta taaaaatagt 120 acataggtca gagggaggat tggagatata tatagatata tagagagaga tatatacaca 180 cacatacaca aacacattct tataatatgt aattttaatt ttatttttcc ctttattctt 240 atcattgtat atgtaatgtt tttgcagccc attttttgcc acttactatg tgttgaaggr 300 catgaaccaa tcacaatatt tgtaatgact tcatgataat ccctctgtgt gtcagtgaaa 360 atgtattcac agataaaagg ctcctgacta actaatttaa gcagagaagg actttgcaca 420 aggcattaaa ttgcttaatc catgacagga gtgagacagc tggatttaat gtctagaaat 480 gacacccaaa gacagcctgc accactaaaa gcccaggaga gttgcttctt tggacttagc 540 attaggccac ttgtattagt cacagttctc ctgagagtat tacacacatc tctctgtct 599 <210> 32 <211 >599 <212> DNA <213> Homo sapiens <400> 32 gtcccagtta cttttgcagc ctctcttttc ctattttgcc ccatcccatc cccacaaaga 60 actacacatt caaccaaacc agactcctct ttccaagaac acatccccac cttttcgtta 120 ctacctattt ttacccatcc tatcctcttt aaatccttcc tcttctacag atttccccaa 180 ttctccaatc aaaagaggtc tcattctacc acgcagccca tgcctctgca ctgccaagca 240 aggcagagca ccaacaaggc aaagtcatgc agaagtggca gcaagatctt tggagtcagr 300 ccaattgagc tcaaatctga ttcagctgct tatatgctgt gtgatcctaa ccaaataact 360 aaatgtctct gagcctcagt ttccacatct atagaacaga aacagggcct ggcacacagg 420 agtcctcagg agaactgggg gagcaatagc tggcacaata gagacttggg tatctgtctt 480 ctctccccct cccccgtaca aaatgagctc cttgaaaggc aatacaatga agcatctccc 540 agaagacctt acacatgagg ggacctcaaa aatggagttg cagagttatc taaaagcct 599 <210> 33 <211 >599 <212> DNA <213> Homo sapiens <400> 33 ttcccgctgc cacaccccac cctgggcccc cgcagacacg catctctaac tcagttgggc 60 ccagccttct ggatggcttg gggtaggcca tgggcccacc tggggccagg ccagcccctg 120 gggcagctct ggaagagcag tgtggaggag cacttgcttg cagcctggct tcagcctctg 180 gcactgctgg agtggtccct gggagcttct gcactgtcgg ctttggggac gtctcaccca 240 cttgggttac agtaggcctt ccccacccag agagaagtgt ttccacccca gagacattgy 300 ctgtcagccc ctgaagtgct cgcctccccc agtgcccgtc accagccctt cctatctgtg 360 gggtccaagt caggcttccc ctgcggccac cagccatagg gagcagccat cagcccccga 420 gtcagaactg cttctgtctg tccatacctc caggctctcc cggagagggg gacggatatt 480 tatttcctaa agtttgcact taattgtgag gattctcagg attgttgggg gctactgaaa 540 agaggaatgt gttgaatgtc gcgtttgctg tccactcgtc ctagaagttt agtgttttt 599 <210> 34 <211 >599 <212> DNA <213> Homo sapiens <400> 34 gaagaggtaa gggaacaatt cggtatctgt gttttatata tcatggatag tcaagaaagt 60 cattctaggc agtagggaaa tgtgcacaga ggtactgcaa ttacatgcgc ctgtaaaacc 120 cagaggctgg cacactggaa gggaaatagt ggagattcct ggcatctcct ggccacttac 180 gctgaggtat tcccactagc tgtgtgccca gcacttcctc tgcatgcctc agatgcattt 240 gacaatctca ggtgaactgc acttcagggt caagggaacc ccggccatgg ttctaagaar 300 caactcccat tttagtatca cctacatttg aaaccacaga gcactgtcca ggagaggtga 360 tggtggtggg tctcctcctt tggctctctg gcccatcagc tgatactagg gagcgctatc 420 cctcagccca catttctcag catggtaagt ctgagagtct tgatgattaa aacacatttt 480 tgtgtgtgca atttcatagg ttttctaaac tcttgaaacc cttgcatgaa ggacaaaggg 540 accccacgtt acacactcct acttcctgga gtatgctaag ggcttcccaa cactggtgc 599 <210> 35 <211 >599 <212> DNA <213> Homo sapiens <400> 35 ttttagtaga gatggggttt tgtcatgttg gtcagactgg tttcgaactc ctagcctcca 60 gtaatctacc cacttcggct tcccaaagtg ctcggattac agacgtgagc tactgcaccc 120 aacccgcctc accgttttta aatgggttac cacatatgta aatagaatag ctcaataaat 180 attcactcca taactgcagg agttagggga aagggaaaga aggtaagaca aggtcaacag 240 aagacctgca ccccagaaaa tccaaccccc atggggcaca gtccaacgtg ggggtgggar 300 gaatttacat ctttgccacc aaagaaacaa atctttgccc cacagcctgg gattaccagg 360 gcaaccctca acgtgagggt aggggaaaac agaagagggg atccattttt cagggggaac 420 atgcttgtct tggcagtttc tctcctcaaa gatcctgaga cctccaaaca agaccctcgg 480 gccccggttg gctggggagc gttgagcacg cccaaggaac gtggacacaa gcccctctgt 540 aatggtgtgc ctatcagggg tcagggatcc agcctggtcc acggtgaccc cggcgggca 599 <210> 36 <211 >599 <212> DNA <213> Homo sapiens <400> 36 ctcctgggct caagtgatcc tctcacctcc accatccaaa tagttgggac tacacatgca 60 tgctgctatt gctctgctaa attaaaaaaa aaaaattaga gatgaggtct cactatgttg 120 cgcaggctag tcttgaactc ctggcctcaa tgaactcctc aaactcaagg ctcacacatc 180 agcttcccaa agtgctggaa ttaaaggcat gagccaccat gcccatccca cactttattt 240 tatacttact gaactgtact caccagcttc ctcaaccaca ataaatgatt caggtgtccr 300 tacaggaagt ggagggggga tttcatcatc tatccttgga gcagttgcta tccaaaatgt 360 caaaaatatt gtaacaattg ttaattagaa caatccaaag gaaattctta tattctaata 420 ttaaatataa atttaccata atttatattt aaattccgtt gaagcaacat tatcagtaaa 480 gttgacactt gttcattcaa ggaaaaagca aaataaattc tcttaaggta caaacccagg 540 aggtttttgc ttattcttta acatttattg ttttaaaagc tcaaaagtag ggctgggcg 599 <210 37 <211 >599 <212> DNA <213> Homo sapiens <400 37 aataaaatat aaagaggtga cattgacaga gttgcaaata atagaaactg ttgtttccca 60 aaggcaaacc cacagttgtc caaagagcac cataagcatg tattttacag catcagataa 120 gtgtctggct tcctcctttc agctgactga ggcctctctc ctatgaggaa gaagctttga 180 gtcctggcca ttcagcatct gccttgtaat gagggaaaaa ccaagaacca aaaggaatta 240 agagactagg gggaaaggaa aacctttttc agcctgactc ccttgctaag tccctcactk 300 acagtatttt agctacctgg atgtcgcatg atatgtgatc tgacagatct ataatgaaaa 360 cagagacact agggaacaat gtgattggag gaacgtaatt acggaatgtg gaacagcttt 420 ccatgggccc tggtgtgtct gcaaggcagt gtctgccatt cctctgggtc attgtcaagg 480 acagtgatca gccttggaga actgaggtca tgtctccctc ctcagcaaag acaggcattg 540 ttagaagatt tggcttccct gtgttcaggg ttggtctcct gtaacaaaac ctgctgcat 599 <210> 38 <211 >599 <212> DNA <213> Homo sapiens <400> 38 ggaagactac atttcccagt ctgattgtat ctatgtgggg ctatgctacc agttctggca 60 aatggactat gtaccagcag cacgatatac cacttcatgc ctagcaccta caatctgcaa 120 gacagcatct gcattctcct ctctgtctac tgtaggatta tcagtgtcca gcaaaaccag 180 gacattcacc aacatatttt gtcaagtaag caagaaataa atttctattg tgttcatgta 240 ctgaaactta agggtttcta ttaaagtggg atgattactt ccgttgacta atacctagcm 300 caaactacac tcaatcaagt atcaataata agcatattat ttattatacg tttgaaagct 360 ggaagagaat tattttgttc aaagaaatgt ggatcaagta tcttgaaagc atttatcagt 420 ttaataacat ttggcatact actttgtgga gaaaaatcac atagggaaca gagtactata 480 cggtaaatgc aaagtccttc tataatattt tctgttgagc tgacctctgc tttttgatat 540 gacaaagtca agaacaatct gaaaaaagta tcaaacacat atgtaggtga gggtgttcc 599 <210 39 <211 >599 <212> DNA <213> Homo sapiens <400> 39 ctgggttgct ggggaagggg gtggaggaga gagtcagtct ctgggtgggc agtgacatcc 60 tgcgtaacag ggaagctgtg catctggctc tgtggacagc ctgtgagggg cttaaggggt 120 actcttccta ggtctctgct ggagaaggag ctggagtctg tgggcatccg cctcaacaag 180 cacaagccta acatctactt caaggtgagg cacctctctg gccttcaggc caggggtgtg 240 gcagttttga gactgcattg gctggcggct gaggctgtgg gaccattgct gtgaccccty 300 ggtcagcagt tctccccatc cctttctcct ctttcagccc aagaaaggtg gtggcatctc 360 ctttaactcg acagtcacgc tgacccagtg ctcggaaaag ctggtgcagc tcatcctgca 420 cgaatacagt atccttccct gaaagacacg tgaaggaggg cagccaccac cgtcagcgca 480 gcggggggac tgactaagac aggaggcctc atggagcagg gtggcagcag gtcaccccca 540 ctgcccctgc tgtccattca agtagcctct gggcaagctc cagactgcca ggtctgcag 599 <210> 40 <211 >599 <212> DNA <213> Homo sapiens <400> 40 ctcataacaa taagaacttg tggtggtagt tcatagaatt aatttctata gtgtttgagt 60 gaaattctat ctgtaatagg gatagctcta taaaaatttt agtcagtatt tagagaaggt 120 aatatttttt gagactaagg atttattggc actccatgct tcctctttgt tgctgccagc 180 atcagacttg ctataactgg aggaagaagg gggtatttac tggatcatct gtaattgatg 240 taccgtggga tacaaactgt gggttcaaag gaatgacttt ctttttcttt ctttttaacr 300 agggcaattg actatcaaga gggggaaaaa agtctctaat aatataaatt tttagaaaat 360 taatttagtg tattatttga tatatatgga gttcttcaaa tagtgcttgc acttgctgag 420 ggctacttgt gttatctggt attattactg gtatttttag agaaattgac taggagtggc 480 aaactgtgct agccagctgt gcctacttga aagggttgtt atgaggctca tacttgttaa 540 tgtacagaca aaggctctct ccttgaccaa actttagaca ggctcctttg agccctctt 599 <210> 41 <211 >599 <212> DNA <213> Homo sapiens <400> 41 gggtggtgct ggggcagtgc tgagggagcc agtttggaag tggcgacctc ctaccctcaa 60 cttcccttgg tgggagtgcc cgcagctacc caggcgtgcc aggggcaggc ctgggatttt 120 agcctagtgt ctttggaata tctagttcag ccccagaacc acatctggct tgcctgagcc 180 aagggaaggg gaacagccgt ggcacatctc tagctgctgg ccctgaatgg cagtttccag 240 gtccgtggca ctccagcttc tggagacaag ggcagatcgc ctcagagagg cctgctaccr 300 cccagccctg ccctcagggc tgcagagctg tccctgccct gccttctggc caccaccctg 360 tcatgatgcc attgcacaga gccacctcca gtgtgaacag gaagattgtg ttggagagag 420 caccagcctc cagctacttt tgggtctggg gtttgttcag aacagtggct ggtgaggctt 480 tgggggaggg gagccgagaa ggggactaga gactgggggg tccctggggg aaaagccagc 540 ttctccctag gtggcagtag gcaggggagt ggagactccc tgagatagca acacctcct 599 <210> 42 <211 >599 <212> DNA <213> Homo sapiens <400> 42 gcctagactt cactactaag catgtaagaa acctgcgctt gtaccctcta aatatgtaaa 60 aatattttta aagttgcatt ttcaaggaat accactagat gtcactgtgg ttttgcaggt 120 tgcacaaatt ttatcagtaa agacataaat tccttggtgg cctgcctctt gactttgact 180 catttctaga ctgggcacat ttagccaatt tcaacacata tagcctttgt gaagcctaca 240 aattaaataa tggtaaaagc aacgaggaag gaggcagccg gcttaaagct tgtttctgcr 300 attacaagcc gtgggagccg ggcagttact gctccgtctc tggacttggt ttccacatgt 360 ggaggagact tggattgcct gctcttagtc tcttcaagct ctcgtagtct atgactttaa 420 actgatgttt tttcaactaa aattatttca gtgcccctta caagattttt gtccaacgac 480 attgaaccca ctactgattt ttctgttttg ttttgttttt aaactcagag cttttattta 540 tatagtactt gtttttaagt tgactcagct ttttaaaatg taaataaaga aaaaaatgt 599 <210> 43 <211 >599 <212> DNA <213> Homo sapiens <400> 43 tccattactg ttattatttg accaggggaa tcatcttagg ctttatggag gagttgacat 60 tttcaatcag ctttgagggt gggtaggctt tggacagaca gggatggggc agaagaacat 120 tctggactat gggcacaaca agagctaagg ctaggaggtg ggactgtgta actttgagat 180 ggagaatagg gaggagacct caaagcagaa ccttaggctc taagggaaac aagacagaag 240 gattctgctg acaagacagt aaagtagcct gctcatctgg tggtaggcac tgtgtcagcr 300 ttctaggttg taaatgtagg aagtaagcag atcagaggtt tgctcaacaa cctgcctagt 360 gagccaaact gcttgctctt gaggccatgt agtccttctg gggcagctct tcaaacccta 420 gtccacagag gcaggtaccc agttctttca gtgatgcccc aagccagata agaaaatgat 480 gttatggaga tctggaatcc tcacccaaaa gtccagcttt cattctaaat gcatccgtcc 540 atcaggacag tcttgtgtgt gttcagaggt gagggatgaa agagaaactt cacagcaga 599 <210> 44 <211 >599 <212> DNA <213> Homo sapiens <400> 44 agtgggctgg gtgtgtaagc aggttctcag acccctgggc agcttgtgtg gtgtgcttta 60 tggcagtagc agtggtggag caaccaaccc acttagaccc agttagtcca tgttggtgtt 120 gctggtggct gccatggatt ggttgaaata gttctcagtc ccccagctgc ctgtagcagg 180 gtagtgggta ttgtcctaag tatgcttagg agagcttggt ccatcttgtt cctcttctgg 240 ctgggtggca gctgcagctg tgtcaccttc aacttggcct gagggcaggc acagcccagm 300 attaaactct caaattgatg ccttggcctt gagactagag aggttggggc ccctcccagg 360 caagcagcat gaacaagaag ctgtggcggg tgcagtctgt tcatgtctca atctcaacag 420 caggctgcac agagtggtag gcattttctc atggggtacg tgggagtgcc tgatctcgcc 480 tctccctcct tgaagaagtg caacagcagc agccatgtct gtagatctgt ggtatctagc 540 ttctcaaaat ggtgtccagc tgaagctgct ctaggcttgg atgtctgtgg aactctgtg 599 <210> 45 <211 >599 <212> DNA <213> Homo sapiens <400> 45 aggcgacttc cggagtgggg ccgcctcatc agtcattgta ccctgctatc ttccagagac 60 agaagcccca gaagcacaca aaccaccaat cagaagaaaa agaactactg catttcatcg 120 attgtaagat acacattttt ttatattaca ttttgttatc tctgaaatct gggtgcatct 180 tacaactgat ggcaggtcag tttatttggc agctgttttc ctttcttaga ggagctaaag 240 taaaggtgcc tcttcaaatg agtggcatgc cagattcaat gaaatatagg atgacttacr 300 gagccctaat tatgctgcag gcatcatttt ggccagttag cacacaccat catacccctc 360 caagagatct gcattacaaa ccacaaaagc ggctcagagg ggttcagaaa acttcccaaa 420 gtcacacagc ctgtaaacag cagacgcagc attcaaaccc aagtgtgctg gggcccaatg 480 catctatccc tctcactata ttggcctcat ctcctttcct tctaggtgaa gtgatggggg 540 acaaggccaa attcagtgtg tcafcttcggt cctcaggtct gtgggtcctg gataattct 599 <210> 46 <211 >599 <212> DNA <213> Homo sapiens <400> 46 tatgccagcc gccatgccgg åacggaggga gctgtgtcca gcctggccgc tgccgctgcc 60 ctgcaggatg gcggggtgac acttgccagt caggtgaggc tggctctacc ctggggggcc 120 ctggaagggt cctgggcacc tccttgcatg tcctggggtt actgctggcc catgagtggg 180 tggttgtgaa gggagctgtg tgggcaggac ccctcccgca ggcatggccg cctgacaccc 240 cgtttcctgc agatgtggat gaatgcagtg ctaggagggg cggctgtccc cagcgctgcr 300 tcaacaccgc cggcagttac tggtgccagt gttgggaggg gcacagcctg tctgcagacg 360 gtacactctg tgtgcccaag ggagggcccc ccagggtggc ccccaacccg acaggtaaac 420 agccctggct gtgcctggcc tggggaggcg ggcaggcagt ggacattgcc gtgtggctgt 480 taggcatggt ggggggcact ggaatctggg cggaaggcgg tggggactcc ctctccaggg 540 agggaggatg gggagggagg ataggtgggt tcccgagaac tgggggcagg ttgcccgga 599 <210> 47 <211 >599 <212> DNA <213> Homo sapiens <400> 47 acattgcatt ttttacagat tgaaggtttg tggcaaccct gcattgaaca agtttatttt 60 tctaatagca tgtactcact ccacatctct gtttctcatt ttggcaactc ttgtaatatt 120 ttaaactttg ttataattat tatatctatt atggttatct gtgatcagtg gtctttgttg 180 tcactatttt agttgttttg gagcatcatg aatcatgccc atataagaca atgaacttaa 240 tggataaatg taggttctaa ctgctctacc aatcagccat tacccaatct tttcccatck 300 gctggggcct tcctatcccc tgacatacag aaatgttaaa attatgccaa ttaataaact 360 acaatggccc ctaagtgttt aagtaaatgg aagagttgca agtctctcat tttaaatcaa 420 aagctagaaa tgattaagca tagtgaggaa ggcatgttga aacccaaggt agactgaaag 480 ctagtcccct tgcaccaaac agatagccaa gttgtgaatg cagacaaaga gttacttaga 540 caaactaaaa gtgctactcc agtgaacaca aatgataaga aagcaaaaca gccttattg 599 <210> 48 <211 >599 <212> DNA <213> Homo sapiens <400> 48 ggcattccat gtacccacta ggggaagctt tatcaggctg catttgcctt atgcagaagt 60 atgcctttgt tctgagaaat ggcctcagaa cacactgttg agctgtctcc tttagtgagt 120 gtcatcctct catccatttc aaaagattgc agatgccgtc ttgaagtcct gcttgtaaga 180 aatgcagggg ttgggaatgg aggagatgac gatgtagttt tgcttttagt tttcccaaac 240 ctgtttacat tttttaaaaa tgtaaccaac ccataattgc attttacttg tcgtggttcr 300 atctgattgt attgtcgaag gactattttt gaacctgtcc aaataaactc tgcaaagtat 360 ttccacaagg atgtgactcc atggcgcttg gacagccttt atcctgaatg gtactgagac 420 acaaatgttt tcctgttgcg tgctttctaa ttacctaaat gcaaacgggg tggaagggag 480 aaagtggaaa ttctaagtac caaaaggaat gttaaattta gaataataag ctcatctgga 540 agctatcacc acttttttct taaagtgcgc tgcaagcatc gcttcccctt ggacaccaa 599
<210> 49 <211 >599 <212> DNA <213> Homo sapiens <400> 49 cggttgtttt aaataaatgg aaccttttgg ggagacaggg agggtggatg tgtcttctga 60 ttttatgagt ctcttttgtt tctagagaat ctttcgtttc tgttgcttgc tttttctttt 120 cctcctttca ccatcaagca tccaggggag gtgaccctcc aagttacctc cctccctccg 180 aagtggtgcc ctcccaagac tttggtcctg gcaacttttc agccccttct ttcatttcct 240 ctgtagccaa ggatcagact tgttctcagt atttccacao ttagggtggt acactcttty 300 tgggggtgat tttcatctgt tccccaacca ggctctgctg cctgactctc ttttctggaa 360 aggtttctgc tgctttcaga cgttcatttt tctccctatg cattaattga agtttagagt 420 atatttcgtg tcctggctat gctacaggca gggctggctt cataggcatg ccaccaacgc 480 ggctgcacag ggccctattc tcagaagggc ctctcacctg gggtttaatg cttggcagtc 540 actgtcttaa aatccttaat aatttagtat ttgaatttgt gttttgtaag tgaagtctg 599 <210> 50 <211 >599 <212> DNA <213> Homo sapiens <400> 50 gaggatttca catttagctg atgaatatgt tagtgaattg aagaaatcct caaaaacttt 60 agcaagtgga acattcctga cgtagtgcgt taactggagt aacctaatat aataaccata 120 aggaaaaaac aagtcatgct ccccagagac tatctatagt catagaaaga agatgtggaa 180 ctttaagtaa ataactaatt ggtatgatcc aaagtgttgt cttgactact agtggggtct 240 ctatttggaa atatgaactg tttttgcttt gaggtttttc acacaaagaa taatcctacr 300 ccagtgaaat ttccgagtgt ttagtaaatg acagagtctt ggaaattggg attagaacca 360 agcaatttca aggcccatct gcaagacaaa gacaagcagg taataaaacg ccctgctctg 420 tttcctcttt ggcctctttt agtttgtgtg aacttttaac ccaagaacat taagtttaaa 480 atcaaattca atttgaagca attttgagcc acacaactgg gtgaggataa atggctctat 540 attaaaatga tcttttccat tagaaatgac ttcttggata tcatttggtc tcattggtt 599 <210> 51 <211 >599 <212> DNA <213> Homo sapiens <400> 51 ccaaaattat aaaactctct gggccaagac tccaaagcat ctaaagaaaa cagaagaacc 60 cagaaagtcc taataataca tgaagggtaa atatagcatg aagggtatgg tttttaaatt 120 tcatatcctc attagtgaat cagcagaatg actgagacat aaccctagat tttcctatga 180 cttttggtaa aattttatgt taccaatttt attcagactg caccagtgtg gtctacatgg 240 taagacaaac agcttcagag tggaactctt aaggcactgg gtgattcaca aattgaaccr 300 agtcagatgc acagtagttg tatattaagt acatgcacaa atgacactaa tggacattgc 360 tgccatggca cgtctcagtc atctgccctg gtgctgttct ttttgcaata tcagaattag 420 taacataaaa cagagggcct ggataccaaa ttcatgagtg acatgttgtt cggagggaaa 480 gcaagtaggt tgaaatgcca tgttagtcaa tgccatcatc cttatctcgt gtaccatata 540 atacgtacac ataagccatg ctgccagtag tcccttccct ctctgttcca ggccttgga 599 <210> 52 <211 >599 <212> DNA <213> Homo sapiens <400> 52 tgaatggcac ggccaccctc tgtgcaccaa aggtttcaca ccttcacctg agagctttaa 60 taattctccc atcttagcca agaaaactct gccacataac ctcaggcctt attaagtcta 120 tgaacagaaa ggtaactgga gaactgcaat aattatctgg ttaatgagtt aaaaatcact 180 cttgcctgaa ataacctggt aataagtaag tcttgctatc atattcatta aaaaagaaca 240 tttctcagag agccaaaagg aatgaggatg gtgttcaaat cagtttacaa gtcagcatty 300 ggggcactgc atacaacttt ccaaagtaaa aataaaggta caatgtatag agaaaagcca 360 ccaagtaaag ttgaaggcac ctcttaattt caaaatgagg atatctagca ttcattaaga 420 ggtcaccatg tgccaggaat gaggcttata gttttatgca gatcatttta ccattcctta 480 aaacacctaa atgtggcagt tactattttc atccccattt ttcagatgag aaagctgggg 540 ctctgaggag ttgcatgact tcctcaaggg tatcctgctg ctaagtggtg gagetaget 599 <210> 53 <211 >599 <212> DNA <213> Homo sapiens <400> 53 tgtaactttg ccagagaggg getatetgag ggcttatgta gttcagctgg aettetgaat 60 atetgeaegg ctcacaaagg aaccattctg agaeagettg cccatctgtg tgeattttet 120 ctgaaaacaa aaggatcaag agatgaaaga ggacaggatg gaggaaaaga gaaggctcag 180 aggtgagaaa gaaagacatg gagaeaggae agaeagagta tcccacactc tggaactcct 240 cctggtatga tattgaatgg aattgctcct ggctttacct ggtgaatgat atccttcccr 300 agcccatgaa taatctgaca gggatcaaaa ttgcctctga gtagcagagg ccccagatta 360 ctcacacaac atteaggtat gcaaaggaaa ttagetaett tatttettta taettgatet 420 aattttttaa tgagccttcc acctgtttgg gtaggaagaa aaaaaaacaa ctatatttag 480 tccaatttag tttaaagtta gtttggccca attatttatg cagaaactct gtattaacta 540 gtttttctgc teagttette aeagetatet tcttcctttc ttgettetet ctgggtccc 599
<210> 54 <211 >599 <212> DNA <213> Homo sapiens <400> 54 ggtgagatga cctataggag caagtggagg taggctagga ggctaagggc tttctctcca 60 gtggaaaggc ttttagttga atgttttagt ttttcagttc tcagtcacat cttctgtttt 120 tatggtatct gagctcacca ctggaatcac tgcttcagtt tccgctgaac agtggccttt 180 ggtctgaagg tagaggaaag catacaagaa ggaacagtgg ttttgctgca tgggatggag 240 gaggtctaac tgctttgaat agacttttac tatctttctc ctttaagctc cacaattcar 300 tgctctcata tccaacttct gtgtattgta ttatcccagt cttgagcctg tgcattctct 360 tgcagcaaat taaattgttc ctcctgtttc ccttggagcc ccaccttttc tgccagtctg 420 tgtgttgcat aatccctcct gtgctggtta ctagttacat aactcatgtg actcaactcg 480 cagccaatta gcataaacct aggtcttatg ttcaaattga tagtcaaatt caagggacac 540 ataagcttta tttggtatga catttgttca gctttaagga aaatataata gaagcgata 599 <210> 55 <211 >599 <212> DNA <213> Homo sapiens <400> 55 agccagcata ttatcttctc cccattaaag agctttaggc catctgtccc atctagacta 60 ccagctggta tgatctccag aaatattcct caactgtagg aactaattgg gtttttccat 120 atgtataaat tgtagattaa ctgtatttac caataaaaaa agttcaattt catctttgtg 180 gcaggtgacc tgatcttaat aatgagggtg aatctcacag gcaggtcctt tgggatggtt 240 gtaatgtttc tactatcaaa gctgttgctt gtgacaactc tgggacattt tttcttatay 300 aaaatcaaag ccagagttat gaactcattt aaaagagcaa ctgtaacaga agaaaatgta 360 ggtttagaag aagtgataat gacatcacca gaagaaggga cactgcaaaa atgtacccta 420 acatagtgtt cataatgctg ttatacaaaa catgatggct ctccaagata aaattaacca 480 tttccagata ggattaaaca taactctgaa tatctatgga catgtgatta aacattatga 540 attcaacaac caagctataa tataactcat ctttgtaagg gagacactta aaaagaaga 599 <210> 56 <211 >599
<212> DNA <213> Homo sapiens <400> 56 taaaatcaat agtgttggtt gtgacaatta tgatgtactt ataaactttt ctttaaaaca 60 tttgtgaatc tgtacacttc tcaacaggac acactgaaac tgcctgtttt atgttcccta 120 tacagtagca atgctcagga gtagtctgct ttaattaggc ctcaaggagt tgagaccgcc 180 tgccctgaac cccaatgagc ctgtggagca caccacagac tttctagtgc tggtttgtgt 240 gagcaagtgc ttacctcagt aaggccttta atcttcaagt acccacaaag gtaagagtty 300 cccgtgtcca cgtgctgaaa agaaaggata cacagcctgt cacaaataga taaacttact 360 aggggacatg caggagggta ctctgcaaat cctgtgaggc cagactggtg gtcagtgaac 420 acccagggca gtccaaggct cacccagtct ctggaatctt gataagttct ccccacacac 480 atgcctgttc tgccaaagca aactgatccc aagaccctct caactttctt cagctgaata 540 tcatgagact gaagtgtctt tctgaaatgg ggtgcccact caaattcatt ttctgtact 599 <210> 57 <211 >599 <212> DNA <213> Homo sapiens <400> 57 accttagtct gccaccctcc ttttaaagaa gtgataagat gggatgaatt tggttcaccc 60 agcctcatac tgtgtttcat ataaaaacac atatccaaaa aaatatatat atatttttat 120 atatatattt atttaaatat atatttaaat atgcatatat atttttatat atttaaatgt 180 gtatatatat ttaaatatac atatttaaat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 240 gtgtgtgtgt atatatttac agcttttttc tcttatttct aggagtcctc gccctacctr 300 ctgttgcaat tggcatgttt tcaggaggat atatcattaa aaaattcaaa ttgtctttag 360 ttggacttgc caaattggca ttttgttctg caacagtgca tctcttatct caagttttat 420 atttctttct aatctgtgaa agcaaatcag ttgccggcct aaccttgacc tatgatgggt 480 ttgtatatat aattggataa tatgttaacc atccaatcaa aagactatgt gtaaggaaaa 540 tagggtagaa aacaattgta attaaatttt cttttcactg agagaaattt catttttga 599 <210> 58 <211 >599 <212> DNA <213> Homo sapiens <400> 58 gtacacatgc ccatgttgaa tagagacagg caagagttat gctttgtgct cttggcagag 60 cagtggagcc acttcctgat tcctaaactg gatgaaagag tgtggtcctg gcctgcagtg 120 catggccact gtcctcaaac actgctttat ctcctgtgca cgaggcctgc ccagctctca 180 cacatgtaat ctagacttct tgtgtgctga gcactttccc ctggtaccat aattaatgcc 240 atctcttcca ggacttccct gaagggattg gtctgatctt ttgggatccc catagcatty 300 acaggggttc ctaacatagc gttcatgtcg aagaagagta taatggtgga gagacttgaa 360 gggctgtagg tttttgggga taggtatgtg aacattttca gtctctatag tatttaaatg 420 cacaattgaa acttggcctg ctaaaaactt tctaaagctc caaacttaac cttatgctcc 480 aggtccaaag gggtccccag agtcaatccc tccccctgcc tgggccatat tctccagctc 540 agagaggatc cttgaaggta aggagatgag gaagcaaagc ccacccatcc tatcaatgg 599 <210> 59 <211 >599 <212> DNA <213> Homo sapiens <400> 59 aatattaacc atcacattcc ccttggacta tggaggccat cctacactac acagttgaaa 60 atcttcctat tcaaccactt gtttcccttt ggttgttcta aacccttcaa gaaaatctta 120 ttcaacttca cgtggcatag agaatgaagg gctggggctg agaaggcagg gcgctcaggc 180 cactgtcatc ctctgctctg ctggggtacc caagtgagga catggattct ggagaggcgg 240 aggaggaagg ggtagccaca ggggtgtggg ggcagcccct ggagggtgac tggatttcay 300 gtttggagtg gaacccactt aagatgtctt cagtcgactc ataagggatc ccaacaagtc 360 aattagcagc tgtaaataat ttacaatgct gagcaagctg ctgaaatggg cagaggagtc 420 atcagtttga aatcttggag agggagacgt gctgatacat ggttggcaga aaagtcactg 480 aagtgcatct taacaaatgg acctcacttc tggcgatgtg ataatgagct tagtggataa 540 caggagtgaa gtgaactagg gtacctttct gtctctttta agcacttaag cctctccat 599 <210> 60 <211 >599 <212> DNA <213> Homo sapiens <400> 60 cacacatcac accagggact tctactcata cgtgaaaagc tagagaatca tgtttaggta 60 ggcaagggga gagaggtcct ggacaggtta ttgaaggact gattttaaat tacaaaatac 120 ctctttatgt ttagtttgca aacaaaagga gtcaattagt gaaggcttgg ctgagctgat 180 ttcagaaaca gtagggaccc actttttgca gtagttagga agcctcagga tctttttaaa 240 tgtatcctaa ttactagcct aggaaagtct taaaagagct atagtttgtt gggagaaagr 300 gatttgcctt ctttagaaaa atctatcttt ggtaatgcac ttggttttga caaaaccaag 360 tgcattggtt ttgttacttt cctttaaaaa ttctatcttt ttaaaacatt cctggaactc 420 atctgttctt tttttttttt tttttttttt tgagatgaag ttttgctctt gttgcccagg 480 atggagtgca atggtgcaat ctcagctcac tgcaacctcc gcctcctggg ttcaagtgat 540 tctcctgcct catccttcct agtagctggg attacaggtg cccaccacca cacccagct 599 <210> 61 <211 >599 <212> DNA <213> Homo sapiens <400> 61 atcagagtga acaggcaacc tacagaatgg gataaacttt ttgcaatcta cccatctgac 60 aaagatctaa tatccagaat cttcagaact taatcaaatt tacaagaaaa aaacaaccct 120 attgaaaagt gggcaaagga tatgaacaga cacttctcga aagaggacat ttatgcagcc 180 aacaaatata tgaagaaaag ctcaacatca ctgatcatta gagaaatgca aatcaaaacc 240 acaatgagat accatctcat gctagtcaga atggcaattc ttaaaaagtc aagaaacaay 300 ggagactggc gaggctgtga agaattaaga acaattttac actgttggtg ggaatgtaaa 360 ttagttcaat cattgtggaa gacagtgctg tgattcctca aggatctaga accagaaata 420 ccatttgacc cagcaatccc attactgggt atatacctaa aggaatgtaa atcattctac 480 tataaagaca catgcacaca tatgtttatt gcagcactat ttacaatagc aaagagatgg 540 aaccaaccaa aatgcccatc aatgatagac tggataaaga aaatgtggca catatacac 599 <210> 62 <211 >599 <212> DNA <213> Homo sapiens <400> 62 cttagtttta ctaaggcctt tactgcttct tttactccct ttctcctgaa agtaatatct 60 caataaatca ttcattgaag aatttccatc tcaggccctg cttctaggac actggtactg 120 ggagcagtcc taagaaagaa accctatagc tggaattctg gagttgaatt atttactggc 180 cagacggtag tgcatcctgg gttggtggag ccatgatagt tcctggctaa gatgttcacc 240 catggtgaac tggcaggggg tgcacatgaa aggagggaca ctgactgatc aaatatctcy 300 ggcatttcaa aggcatatgg aaaagggtaa ctctatgggc catggaattg ttttgctttt 360 gctaaatgtt gtagatctag agatcatgat aatctcagat ctattaattc acagtttgat 420 gtaaatatga gtcagagggc ctccttagga gcatttaaag aaatcctaat ttctgtaaat 480 ggagggcaga gaaaactgat ggcttgaaac agaacttaat tggaagaggc agaaaatttt 540 ggagaaactt gaattctcaa cctagggaag tttcctaagc caaagtcaga gttctgata 599 <210> 63 <211 >599 <212> DNA <213> Homo sapiens <400> 63 gcctgcttgc tgttacctag caggaaggtt agagatcaaa tggaactgtt gctatgaaaa 60 tgtgttgtta cctgtaacag acatgtatgt gtaatacgtg tttctttagg gccagatagc 120 aagtgacggg ccaaaatgca ataggtatct tttgagcatc atcacatcaa gtctggagtt 180 tgttcotcag acacagcagt atcccaggca ttcctttatg tagtggtcag tgcagaagcc 240 tgagactcac aagcaggcac aggggacatg tggcaacaac tcattctcaa accgtaaaar 300 tattgaaatt tgacccagga aatccaagtc aattatgtgg ggaactcata tagagcaaga 360 gccattctct tttcacttgc aaaattctca gcaaaataac tgatctttct gcccacttaa 420 ggacatgagt aggaggttaa acaagcacag tttgcaggtg gggctcatac tgaaggtcag 480 cttgagagtc gtggaaaatt ccgtggtgga acacaaggcc actgaaagat catttcgtca 540 gttaccagca gggtggagtg agactggggt ttcaccaaga cattcactca ctagctgtg 599 <210> 64 <211 >599 <212> DNA <213> Homo sapiens <400> 64 aaaattttca tcttataggt gattaaactg aggttcagag agctgaagtg gcttgcccaa 60 gatcacttgg ctattaagtg gcagagctgg atcttgatga catgtcttct gatggctagt 120 attattctct ctaactgata aaaacgtgtt tctgagttga ccaccctgac catatgctct 180 agtaactctg cgttctgctt tcaacttcta aagggcattg gggaaaggca gaaatgccac 240 gtgaactgat acttctctag attattaata agatgctcca tacacttttt ggcatcatay 300 aataagtgac aaaactttca gaatttctgc aagtacctaa tgtagaacca tggagaattt 360 tagtttatgg aagttagtct gcttgtcctc tcttttatgg tatcattctg cagggccagt 420 taaagtggat ttgggcctca gtggaaaaaa ttgagattct ctcaacaaga cagagacttt 480 gtgctgaaat gcaaattgtc aatcaatacc actttatcag gtttctgggt ttcccccaaa 540 gtgtgagttc cgtaccaata tacaacatca acatgcaggt atcatcaagt cctgataat 599 <210> 65 <211 >599 <212> DNA <213> Homo sapiens <400> 65 gttattcctg agagggctat gttcctgaga gaacaaaatt attgtttttg aaactctaga 60 gagaactgct ctggcaaaag aaatgtatct tttcatctac agtcattctg aggtgaaaga 120 tctcatgatc actctggact atacaaccca caagcagact tcaaggatac ctacaggaac 180 cccagaagtc ctgattgatc acacaggccc taaagaccct atcaacttgt ttatcaactt 240 gcaattctaa tttcctgaga gtaaaacacc agtaaaaaat aatctcctcc ctcaatatty 300 tagagaatgc aaagaaatac acagtcactg tagacctgtg agcttttgcc aagtttggtt 360 ttcattatta tacatatgaa gagaatcatc ttcgccaaaa tctataaagg ggctgattaa 420 ctcagctctg tagtaattgt ttcatattaa atcagtccaa aagtttaggg catgtttctc 480 aggaactctt tatctagcat caggtatgta tctaaacagt atagtatctg ttaattttga 540 agttatataa aaaaagaaaa tgtgcatttt cacacgtctt agtagaagct ctttacagt 599 <210> 66 <211 >599 <212> DNA <213> Homo sapiens <400> 66 aagctcctcc tcctgggttc gtgccattct cctgcctcag cttcccaagt agctgggact 60 acaggcgccc accaccacgc ctggctaatt tttgtatttt taatagagac ggggtttcac 120 tgtgttagcc aggatgatct cgatctcctg acctcgtgtt cggcccacct cggcctccca 180 aagtgctggg attacaggcg tgagccaccg cgcccagcct gaataaaggc tttttgacaa 240 tggtccaggc agccctaggt tttagatatg tttttctaca gttatagaag ggcactcttr 300 tcctggcatt gatgagaaca gtatcacatg tgttggcctt atgtatttaa gttttaggta 360 agattgtatt tgaaaagtga gctctagtgc aaataaaaac tttgaaaact attaaatgaa 420 atgagcctta aggagtcttt taacttttta agaaatatta cgttttacag cacctcttct 480 ttagtttcac ccatggaagc accagatgaa gaaccttccc agagaacaat gtgtgtgaca 540 tgtccatcca. ttctgccttc tcctaagagt ttggacagct aatccgttca ccgtctaaa 599 <210> 67 <211 >599 <212> DNA <213> Homo sapiens <400> 67 cacggctttc tcccctaaca gccactccac ccaggggcca gaaactgact tcacctctgc 60 actgaattcc tccccccatg tctccctcct cccacccatc ttcctcctgg tgcttccagc 120 agagccaaga aggcttcgcc ccacctactc ccctcctgct gacacggacc ccccacacac 180 acacccaagg aacaggaata ccaaaaatga tåctaccaga gtgaagcgtg tcctgcagac 240 attatctctt taatcctaac tataatagtc cctatttcag agatgaggca aatgtgagar 300 aacaagtaac tttcccaaga acacacaacc aagaaaaaag aaagccaaga ttcaagtgca 360 agtctgcctg ggggtctgga gccggctccc ctgctgcccc ctgccatccc tcccttccac 420 tcccacagcc ccattttcca cccagaagcc ctcctggaag caaccctcac ccccgggccc 480 cgttattcta agtccagttg ttcacaattc attctacaag ccctcatgta atggaatgct 540 aaaatagaac tttgtcacca gctccttttt tatgttggtc tcaaagctgg ggacaaagg 599 <210> 68 <211 >599 <212> DNA <213> Homo sapiens <400> 68 tatttttcta ttattaacat aatgaactta tttaagttaa agtcttacat agcataatac 60 agttgaatca tatttttaaa tcaaaacttg caatctctgc ttttctgatt ggattattta 120 atctattcac ttttaatttt cttattttgg gagttagatt tatgtcttgg actttacttt 180 taaattttta tgtctcatat gttatatttt ttgttcttct atttctactt tactgctttc 240 atttgcacta ggagaatata ttttaatgtg gcgttttaat tcctttaatg tgtttaaagk 300 tatatttctt atgacttctt ttctggttgt tatagagctt accatagaag tcctagactc 360 atactcatct aacttaattc ttgtctgata tagatatatt attcatataa agttatattt 420 tactatcctt ccatttgttc cattattttt atacacatta catctttaaa tgttattaag 460 ccaaaaacgt attattataa taattacttc atagaagttt gtcttttaaa gaagctgaca 540 ttttttaaaa aatttaaata agtatgtatt tatagctttt gtaatattaa ctttcttac 599 <210> 69 <211 >599 <212> DNA <213> Homo sapiens <400> 69 agaagcatta ctccaagagt ctagtgttgg ctctcttctt cttgtggtcc ccatgacctc 60 agcactctat gcagacaaat atatgaatat atctacagct ctagttagga aatgggcaga 120 agtaactcaa ccatgtcccc aggaccaaga gcagtctctg gcatgtagtg ggtactcagt 180 aaatagtagg gatttcagat gaagagaaca ttgtgaacag aggctgtgca tgtatgtatt 240 gatttatttg gaggataccc ctttcaggct gctgaactcc tcaaactcag gaactgtgcy 300 ttttcctcat ttttaatttc ctgatccagc ataatacata gtagctgttc aatacatgtt 360 tgctgaatga atgagtgagt ccaaggtcga tgataaattg atgcaaaact gtggcagtcc 420 ttatatagga atttaggctt tactgtatgt gcagtaggct tgcagccatg caaggctttt 480 tctcatttga gtaactcaat tgaagctgag ctccaggatg actcatgtgg ctgccgtcag 540 cattgaaacc ttgtgccgtc ttcctccctt gcccttgctg ttccatctct aatcagtag 599 <210> 70 <211 >599 <212> DNA <213> Homo sapiens <400> 70 aaataaccag ttagccctgg ctgaatgtcc gttgtctaca gggccacctg gagccagcag 60 tagccagtcg ccttgccaac ttttgttctc tctcagcagg aagaaaagag acaaagcagc 120 tactccttga cttttcttgg ttcaaaaaga atacttgaat tataacagaa atgggagagt 180 gagagtgaat ttcaatattt tcactgtgaa agacaaaata cacacacaat taaagagatt 240 attttgttca gctcttgcat tagggggaga atgttcatta atgaggaacg tgtcaaagay 300 gggagagaga gaacctagag ttttataaaa caagagagcg gttgaagaag ggtagaaata 360 ggtcacacct gggaatatac tagatcatcg caggggtctt agttatcaac ctagccgttt 420 ctcagaacgg aaaagcaggg cgtgaatttc tcgaccatcc ttgctttcta ggagcacagg 480 actcagataa agtttaacat ttctattgaa ggacatcaat atatttaact ccaaagtata 540 ttttttgaca tattttaaga tggctgccgc agggccagca gaccaaaatg gtcctgcaa 599 <210> 71 <211 >599 <212> DNA <213> Homo sapiens <400> 71 acattgattt ttcttcctat tcttttcctt cagaagctat agtgatgggg gctccaggag 60 tttttaatgt gattccagat taattctcta gcagtggacc gggaaggtag aattgatcaa 120 attctaggac ccagtctcct gggcaaatcg aagcacaaat tagaataaca aaacaaaaac 180 tttatgtgtg tgtgagtacg tgtgcatgtg cgtgtgtgtg tatgaaagta atgaaagccc 240 aaagccagga cctcattttt tcagttccct tttgcaggga gaacttacct atgggtaccr 300 ttttggagga caggaatcaa ggcatatact gaaccctgtt ctctttgtga gtgaccctgt 360 tgccatttgg gacatctgaa acagggcatg ctttcaaatg cagcatagtg acaatccttt 420 tacacgttgc tcaatagcaa aattggggtt aagaaagtga ctgcgcatga acaatttttt 480 tttttttttg agatggagtc tcactctgtc acccaagctg gagtgcagtg gcgtgatctc 540 ggctcactgc aacctccaac tcctggggtg tgaacacatt cttcttgtgg cctccctcc 599 <210> 72 <211 >599 <212> DNA <213> Homo sapiens <400> 72 gtggtctgag tgggcttctt actgtttact tcatacattg agcaaactcg ctggatccca 60 ggcagggttt gggatgactg caggctgctc ccacagggca ggtctactcg gatgtgcatt 120 ctgcacggac aatgcagggg aagaaggtgg attcatgccc ggctctcctc ccccatgctc 180 tgccttttct tctattcata gtacagtcta ttgctttctg gctcttataa ttgtcagtta 240 tttcatgcag cttgaagggc agcagtgcct aagacagagc caaagagatg tgctgctgay 300 gagcataact tttagtgaat ttaccagtcc tgaagagaaa catggaacaa tgctttagac 360 tgtcattgcc tcaccaaaca tgtttgcatg tttgcaaata gcatcaaact tagagaagag 420 ctagtgggta gactttctct ttttaaaaaa aatttttttg agacagtctc gctctttcac 480 ccaggcttga gtgcagtagc acaatcttgg ttcactgcaa gttctacctc ctgggctcaa 540 accaccctcc tacctaagcc tcccagggag ctgggactac agacacgtgc caccatgcc 599 <210> 73 <211 >599 <212> DNA <213> Homo sapiens <400> 73 tagcaggcct gcatctggcc agaactgctg tgggaccttg gaagattgcc tggtacctct 60 gggttggccc accgtacata tcctcttgct tcatgatggg agtcagggtg ccccagaaga 120 ggcagcgaaa ggttggagct cactctgccc ctttgctcgg tcagtggaga gagcggctct 180 ggcaaaactg aggccaccaa gctgattcCg cgctacctgg ccgccatgaa ccagaaacgg 240 gaggtcatgc agcaggtgag tctacctgtc tccccaggac cctaggctga acaccctttr 300 ataagcacac ctcatgtact cccgaagagg caaggctcct tggcccacca ggaagatgag 360 gaggctgagt tccagaaggg ggccttgccc agggctgctt tttctgccac ccttcccagg 420 ggtgtgcctg aggggtgaga gttcctgcct gtctgtgttt ctgtggcagc tcctgcttcc 480 agccctccgg gtccagttca gagtggagac cacataggga aggggagtcc acatagggaa 540 ggggagtcat cccatctctc ccacctggcc tcaccttcct ggtcatggcc ctggggcca 599 <210> 74 <211 >599 <212> DNA <213> Homo sapiens <400> 74 tgcatacata atgcatataa cagcacacaa actagattca gccatgcaaa tcatcttcaa 60 cctgcccatc tataagtttc tgaaagccaa aagataaagc atttcaatat tttacatatt 120 ccaccttatt ctataaagat acaaatactt cccctgtgtc tgccttctgc aggactcacc 180 agctctgtat ccttgagcca aggctttctg ctttccaacc tttagcatct ccttgttgat 24 0 gtcacacacc acgacacgag acccgcccaa ggaatcttct tcattctggt actctttggy 300 aatttcttcc caggataaat tttgttgggc ccttaactgc ctcttctgtt ttctctgatg 360 ctgggactga acataattaa ggaaccggaa tgcaatgtca cctgtgggaa gccaacatga 420 ggaaagatgc agactaaaac aaaaataaaa aaggaagaaa cagcatttcc taaaacccaa 480 aggggtaaca gaggcacagg agtacctgtg ttagctaact ggatgcagtg tggctgaaag 540 ccaagtcctt tcttcttttt gttagagaca gggactcact ccatcaccct agctggagt 599 <210> 75 <211 >599 <212> DNA <213> Homo sapiens <400> 75 ggagagcaaa tgttcagatt tctttttctt tgacatgttc tttttatttt tcttccattt 60 agttttgaga tgtgggaagg ttttggttga ggaatcataa aactcctctg gcatctattt 120 tatgaaatat gtagcatatt ctattggaaa gaaattgcaa gcttgctttt attattatta 180 ttttatttta tttgaagctg acatataacc aatctgcaat gccagtgggg gagtctcata 240 aacagaaagg aaaatataaa taaaattctg ctgaatagaa gagatgacag ctaaaatgay 300 gaaaattttg tggtggtgaa ggcgggctgt ttaacttatg gtataaaaat aaggggatgg 360 gtcctcccaa atagttgtaa gtagttcagc atgaacccaa atcggccctc ttgaccacct 420 gtagtgagtc ttgcaaatta ccaaccccat gcatctgctc cgagcttcat attgatttac 480 aattttcttt gttggtcagt ctctgcatct cttgaatgga ctcatgattt gtttacttgg 540 tatccatcaa ttcaggtatc tctttctttg ctctttctct gtctctgtct ttcctcgtt 599 <210> 76 <211 >599 <212> DNA <213> Homo sapiens <400> 76 gggaatagac gatataaggt cctgattaca gtctaaaatt ctcttggtga tcccagattc 60 agtttccttg ctgatgggtt tatacctgga ctaatcagtc agccagcctg gcatggctaa 120 agtccagagg ggcatacaac ccccaggtct ctgtggcagt catgggaaaa tgccacggag 180 attgtgctta aagggaggaa ctgctgggag aatttgataa cctggaattc tccagtggct 240 acaccttcaa ggtgtgctgt agagtttaca ctgtcctcac atatatgttg ggctgctctm 300 agccaatggc taagcaagca gggaaattgg agctggacca ttcctgacaa atgaaagact 360 tagtcaatgg gcagtctttg ctttgagggt ccccattagc ctggttgaaa ttctctgaga 420 actgcactct aatcagaggc tctttctatg cagccctcat tacacctctc tctactttca 480 aaggggtcaa ccttgcattg tggtctgaag tctccacacc tacctctgct ttctatcgtt 540 tgttcacttg catttcctcc aacaactgtc ctatatatct tgttccttct tgataactg 599 <210> 77 <211 >599 <212> DNA <213> Homo sapiens <400> 77 gaataggaca tggaaccaga agttttcagg caggaagtaa caaagtgagg cttgtfctatt 60 caaaagataa atcagacatg gaagttggac tgaagcaggt gagagactcg tagcaggaag 120 accagatgct taacctcctt ggatggattc tgttttaact gacaggaaga cagttggatt 180 tcctaaagga gaggcttagc ttgtgggagg aagtgcagtg gaaaggatat gaacttctca 240 tcatcctggt tcagcatccc aggtgcgcac ctgagcatgt gagtccccct ttgcccaacy 300 tccagtctca ggcgcctcac ccaccacagg aggggatgtc cccagcctca ccgggctgcg 360 gcgaggcggt gcagtatctg tggacagctt ctggctgatg cctgccacat gggtgggact 420 cggggtagct gagtttcctt ctccttctct tctaacttct tatccaagga aaaggaaaag 480 acctgtctgg ccttccataa tcagtaaggt aaattca'tcc .atccacagag aaaataaccg 54 0 ggaagcctac agtgcacatt ttctctctgc ccccaccccc tatgcccatg ccgcatcac 599 <210> 78 <211 >599 <212> DNA <213> Homo sapiens <400> 78 agtgcccctc atcccacagg gtcatgaaga agagccctag ctgaaactct tctccccagt 60 gtccctctcc ttctaatcct tctccattct tctcctgagt ctagccttct gctgaagagc 120 ccttaacaga gatcactacc ctatgatcct gcacatccac atctgcgact ttaatgttcc 180 ttgaaaaggg tttacatagg attgaatgga gggagggtta ctattgtttt tacttcttct 240 ctaagccatg tctcctctct cacacaccag attttagtgg cttgacttct gtgaacacar 300 ttttctgtca gacacttatt ttgttgattt agttctgttg gtaaacattg gagcacagtc 360 ttacagtcat ccccccgcag ctagaactgt gagctactag gagctaaaaa taagagggtc 420 tcctaggcat ttaaacaaat attgccgttc aacagagtct ctttctttat tctaagaatt 480 aaaaaataag gtccggacat tttttttcac atagttaagt ataatctagc taaaaatagt 540 gccatgtttt aatatctgta acctagaatt cttatccaag caaaaacatt ttcacttct 599 <210> 79 <211 >599 <212> DNA <213> Homo sapiens <400> 79 gatgggtctc acgctgggct ctgacctttc ttcttcccaa accacccacg agctgttgga 60 agttggggct gtgtctctgt catgcctgta ctcctctggt gcctactggg tgcccagtga 120 gtgatcaatg gatgcaagaa gcagcaaata ctgttggctg catctgatat gtggttatca 180 aatataaggt ttcaaatgaa ccttttaggc ctaagagtct tttctcaaca aatgattctt 240 gaggagctat tttcacattg ttcaaaaggt ttatgtctgc tcaccactca acaggcaacr 300 tctgacattt taactaactg cttcttgtgg actcatccct ggtgagcacc caggtaccta 360 ccacataaac agcttgcaag aggtacttga tgaatgaatg aatccatcaa taaacaaagg 420 ggctacattg taacaggtgg cctgccagta tgtctctttc cttagactgt gagttccagg 480 agggcaggaa gattttcgca tttatttttt attccctgga gcaggcagga aggtccccgc 540 atatttcttg aatgaacaaa gggatgaatg aagacacact cgtacaaata gatgcattg 599 <210> 80 <211 >599 <212> DNA <213> Homo sapiens <400> 80 ttgacttctg ttcaaatgga gctcaaagct tatctcccgt gtccataaac aaggctgttc 60 aaacaggtta ggccacctgg ggtcggaagg tattttaaag tattttaggc atgttcaaga 120 cattatacgg ggcccctgac agccatcaga tatgcagaaa cttatgtaca aacacatcaa 180 gtgagacttc actggataaa aagatttcca aagccatctg gagttggaag gtattttaaa 240 gtcggccaca gcatcattgc aggctggccc cctgagcttg tatttctgct ttgttccacr 300 cgagcttcct acaaccttat ccattcattt caaaatattg aactttgtat tttttctaaa 360 attttaaggc tttataacag agtttcagga cgtctagtct gccatattcc tagaagcaga 420 actctcactt tattttataa tacactggag tcttgcaacg tgtctttcgc agtggaggcc 480 ctcacatgtg tgctggatga atgtgtgacg gctgcttttc acatgttaat tccatctctc 540 ctgtcagata ctcttgcatt tctttcatgt ctgccctagc gtctagctta gtgctgtgc 599 <210> 81 <211 >599 <212> DNA <213> Homo sapiens <400> 81 aggagaatgg cgtgaaccca ggggaggcgg agcttgcagt gagccaagat cgcaccactg 60 cgccccccag cctgggcaac acagcgagac tccgtctaaa aaaaaaaaaa gacttcaaaa 120 ttacctttta attacaataa tatattctgg attgtcttct tctgttactt aatttccata 180 tccctcaccc tacaacattg tgcctcttct aatagttcat tgagaagtca cccagtctca 240 ccaatccaca cgataatgct gataaggcag ggtgtctcat ctcaaatcac cacctcctar 300 agtaaatata ctttactgaa ataaagtatt gtctgttgtg gggcttaggt taataagaaa 360 taatataagt agtaagtact ctaaaatcct ggctttgttt caaagtaaaa ttagatgttt 420 ttggtgaaca ttcaaaagta ggaaaaaata cactataatt tagagttgct ttgaacctag 480 agatttatct aaattacaat aaatatcaga aaaatcttta cagtaaaagc aacttcttat 540 aagcagatgc tttaaattaa gaattcagtt ttgattattt gtttttcttt ttgtaaata 599 <210> 82 <211 >599 <212> DNA <213> Homo sapiens <400> 82 tggaatggtt tggccattgg aaaagcattg cttttcctaa aattgatata gactatctag 60 gagatcgtgg aattcaagac cctaaggaaa tattttgatc ttgagtttga gaagtaggcc 120 tgccttcagt tctaagagag agaataaaag agcaatacta aaaaatctgg atcactacaa 180 ctttaagctt ctggaagtgg cctcaaacac ctgcccagat tctccatagt gcatagttcc 240 tttctcaatt cctgctgaga tgctgttcac ctacctgaga ttgcattgtt cttttgctty 300 tttgctttcc agttctgatg atattacttc acctttcctc ttccaagata tgaaataata 360 aattcaaaga acttccagac aaacccggcc cccatcaccc acaattgatc catcaaccaa 420 gctacacaac atctggagat ttggagtagc ctgtgctgct tgcaatctgg gttttttttt 480 ttttttgaat gaggaaaaat aatgcaacag ttatgaacta gaaaaggaac ttggatgtgt 540 atctgggggt agacagagtg atgatgatga tgtcccctca gtggaatttt atttctata 599 <210> 83 <211 >599 <212> DNA <213> Homo sapiens <400> 83 caaactctgg gttatttttc aatcccctgg gttaagtcct gggtgattac cacagcatcc 60 ctttcctcta gatcttgctg ctctacaaag ccatacagag cccttcagat gttcaaacac 120 agaaatggtt tcataataat ttatttgtaa cagaactctg ttgtttgctt ttctgagatc 180 tgctcactca ggaagcaaga ttccttaggg caaaatctct gtgcaaggca caaggtgaga 240 ggctcagaac atattgcacc gatttaaata aaaaaaacct ctccttggcc tgtgtgtctr 300 gctcctccgc tgacagagtc tttctcatag gagaaagaag agaaccagga aaggtgatct 360 ttcctaaaca cactctacca tcttagatat ctttacaaca ggctttcaga actcttgtgg 420 gggacatatt gcactgccca atttaattgc cagtgcttac tggcagtatc ttaccagggc 480 agctatggtt ctgcccactg tcaataaaat gcgcagagtt tcagtgaagc aaaataaaca 540 ggctctagag atctgctgta accactgtca acaataatat actgtacact taaaaatgt 599 <210> 84 <211 >599 <212> DNA <213> Homo sapiens <400> 84 ctggatggtg gcaccctgga acatggtaga tgggacttga gggcctgctg ggggtgggag 60 tctgtgaccc tgaaggagtc ttctcaccct gactcttcat taggacaacg tggcctagaa 120 ggaaggacca ttcagcaggg tcaggagcct cagctgggcc ggccaggctg gcaggggtgg 180 agatggcccc ctcgcttccc accagggact ctgagtttga gacttgaggt ctagcaccac 240 ttccagagcc ctcagaactg ggacccactc taggcatggg gagccaaggc acagtctgay 300 ctacccccaa atccaaggac cagtaccctc ttggtctctc cctacttcct tgtttagaag 360 ccagtctcag aaacagagct catcctcaac ccattccaag aagtagagga tgaaacagga 420 tttaaatttc tgggaatttt tatatcttac ctaaaaaccc ttgaggcttg aatggggaca 480 ttccaagcat gcagaaggcc actgtgtcac ttggatagta ggcccgtgag atcacctgga 540 actgtgtttt cctctctgcc ctacagacct gtctcctcct cttcctaggc acatggaca 599 <210> 85 <211 >599 <212> DNA <213> Homo sapiens <400> 85 ccacccctat tcccagtata tttccctcct gtgtcaagcc acactccatt ttctctgact 60 tgtttccttg aatgttttgc agaaaaaact tgtctgagat catggataca tttctatgct 120 cttgcctttg ttccagccat tgtctctttt tagaacagcc tgcttaactc cctcctggtc 180 tccagcgggt ttcttatctt ttacttatcc taaaagcacc tcctacagtc taacatcctt 240 tatgactcct tctttttatt gttgtttttt gtttgtttgt tttgaacaaa gataggagay 300 agcaaagcag cctgggtctt aacagaacag cttggaattc cagggcctaa attgcttttg 360 caaacataaa cacacacaca gcaaccatga gaaaaatgaa aattaaaaat ggcttccaat 420 tcagatgcca agaggctcag cctaaatggc cttctgcata attcactttg gacactttca 480 tcctctgtag gtgaggacaa caggtctgga ccaaggttaa taccttaaat ggttcgaaat 540 aactgacttt gggcagggtg cagtgcctca tgcctgtaat cccagcactt tgggaggct 599 <210> 86 <211 >599 <212> DNA <213> Homo sapiens <400> 86 cctgggggtc ccgaggcctg ggcagaaggc actagggtgc actaacagga atttaggtgc 60 tgccagcttg ctcagcatgg aggaaacctc tgcagaggag gggtggactg atgaagagga 120 gcagcagaag acaatttcac accgagtgct tacaaagtgc caggaaccat attatctcta 180 atataagaca cgctgccagg tagttatcat cttcatcatt ttaaaaacaa gtaaagtgag 240 gcacagaatg ttatgtaacc tgtgcaaggt cacacaacca gaacatggcc tctctaccty 300 cactctacat gtactaatct ccatccccag ggccgagagg ccgcaaccgg atggtgaggt 360 ttagtcttag ccctgatggt ggggtgggga ggggacaagg gtgacttgaa aagctctccg 420 ttccccttgg cagctgtctt tccattcgca ccccctcctg cacccctctg ccaggcctgt 480 tgatcacaga ggcaccatcc catctgctcc gcctagaagt tcagaatctc ccgagatttc 540 tgaagcctcc agcactgttc tttgtgacac tctaaacaca gcagcttctc ctcctgggg 599 <210> 87 <211 >599 <212> DNA <213> Homo sapiens <400> 87 aatagggaga gagactaagt tcaactaagt agaagcaaaa ggtgagaagg ttttgaggca 60 cttggttgat ccagtgaaaa agaagttatg gtgaagatta atcaatggga tgttttgagc 120 atattgagtc gttcctgagt ttgcaaatgc ttttccttgt gattaggcca tctgtgttag 180 caaatcagca tacccacaga aattaagcta ctactctcct atagaggatg gaggatagaa 240 gtgttatttt cttcatgttt acatttcaaa gagatggttc ccagcccttt gagacagacr 300 ttttctgggt tgtaaactgg aaagaggcta tttacagcca tttcaaagga acagaaaaag 360 agtatacaat tggcaagttt tctacagtaa atgctgtaag taaaggggga tcaggagcct 420 aaaggtagaa gaagcctgtt taaaatgtgt aaagctgagg aaaacattga ttccatgttg 480 gttagtagtc attaatcttt aatatattct tggaactgtg ttatttaata atctcattaa 540 atatttagaa caattttgta aaaaaaagat atttatctcc attttacaga aaaataaaa 599 <210> 88 <211 >599 <212> DNA <213> Homo sapiens <400> 88 cagtggcagc cagaaggctc ttttctcaca gtggaactgc agggggtggg gggaggggaa 60 atgataaaag aattttcttt tttaattttt gcgatttttc atccatctca atgcatcagc 120 tgtttggcag cagcacaagt cagagacata tgtccatcgg atttactcct ttttcactgc 180 ttccattgaa ggccaagaaa ttcttccact gtgacttcct cccccattcc ggaaaggaag 240 tccttagaac ttttgcctgt aggaccccaa atgtcgcaag cccttagaac agtggtcccy 300 aaccttttta gcaccaggga caggtttcat ggaagacaat ttttccacta ccgtggggag 360 gggggtatgc tccacctcag atcatcaggc attagttaga ctctcataag gaggacaacc 420 ttgatccctc acatgcacag ttcacaatag ggttcgcgct cctatgagaa tctaatgccg 480 ctactgatct gacaggaggc ggagctcagg agagcagcct gggagttggg gagccctgcc 540 ttagaacttg cctataggac cccagatgga gaacaggcca tggattgttc ctcttcacc 599 <210> 89 <211 >599 <212> DNA <213> Homo sapiens <400> 89 ctgggttggg gctttctggg acttctatta ggtgagaatg tcccaggcca gctctcccct 60 acccctccca acctggggtg gttctaggag ggtgctgggg gtcaggcagg cctgggtggg 120 aatcctggca cttctgactg gctgtgggac cccatgtaaa catacaatct tatagagcct 180 cagttttcta atctataaaa tgggactaat aataataata gctgctccat gagatttttc 240 atgacattga agttaatctg tataaagctt tcgtcactgg cacatactga agttctccay 300 agatgctgtg gttgctaaat catcctggta agagactcct ctagtacgtg ctttagaaag 360 cagctcttct ggataggcgt ggtggctcac gcctgtaatc ccagcacttt gggagtccga 420 agtaggcaga tcacttgagc tcaggagttc gagactagcc tggccaacat ggtgaaaccc 480 tgtctctact aaaaatacaa aaagtttagc caggtgtggt ggcgtgtgcc tgtagtccca 540 gctactctag aggctgaggc aggagaatca cttgaaccca ggaggtggag gttgcagtg 599 <210>90 <211 >599 <212> DNA <213> Homo sapiens <400> 90 gcagccaggg ccctggcaca cagggcctcc ccgatgctta aaccctgccc aagcttgctg 60 gaaagattca ggggagaaac tcccagaggt ttcaggagag gaggagcaat gatggggaag 120 aacatggggt ggtttgccag gtatcaaatg ctagaaatga gggcctggaa atagaagctt 180 ctgacaaaga gctacccttc tgtgcatgat agattagaaa cttgcaaact ccaaagatgg 240 gagggcatgg aattcaagag ggtggggatc aataaatatc agagtcttta ttcagactcr 300 gtagggaaac aacctttaag gtcaagaagt caocagatct taaaacatgc cctggtgttc 360 ccacagtggc agggagcctg aaggtgcagg gtggcagagg ggggcccagg gtggtggcct 420 tggccaggga atctctagat gtgaaaattg ctctggcagc cccaggcttg ccctttgctt 480 gggtcctgaa cactcagcat attacactca gggagcatga gccgcttcct tcattctgca 540 ggggacagtt gccttcccag gtacctggcc tgaaatcctg agtgctgagg aagggcatg 599 <210> 91 <211 >599 <212> DNA <213> Homo sapiens <400> 91 cggtggggtg agagcattgt aggtaggtaa gattggcttt ccaccccact tctcccttcc 60 caaactagat gcattccccc aagtattgtt ctcctaaaac cacttggctt caaccaggta 120 ccaggtgcag ccaactttct atgcaatgaa aagaagccag gatcaagatg aatgcagaac 180 taccatcaaa aatccccttg tctgcttatt cttgcaagca gacataagat ggcctgataa 240 agaattctat gatttcagtc ctaatgaaaa cagtatgttg gcccaggacc caggtactay 300 gttttaagtc tccctgatgt gctgactggc atggacgagc ggaagaagag ggttgatgat 360 gccacaacac actagcagat gggtcacact acattgtgaa ggtgaatggc agaagacgct 420 cactctttgg tccttgctac tttggcagca acagctcgaa atcgacgcta agagttcctg 480 gtacaagcag actctgctag tcccatctcc tctaggagct cattaattta ctccaaatag 540 ccagactttc tttttcattt actggtttcc gaatcaggag aaaacacata aaggtagag 599 <210> 92 <211 >599 <212> DNA <213> Homo sapiens <400> 92 agttagagta ggaaagcaag tcacttatcc tcttcaagct ttattttcct catctgtaag 60 aaactacctg cctcgaagga taatttcaat aatatacgaa aagtccttaa cacagcttgg 120 agcatagcaa caatttaaag taaatgttag attgaatcat gatattgaac agctaggaaa 180 acccttctct gaaattcaga agtaaaggca attttgaata gaacacaacc aacctatttc 240 atttagcttc aaaatatttt tgtgatatat cacatacctt tctcctgaag atgaattaay 300 aactgaccaa ttctctggag ctgaatagga ataaaaaagt cacagtatca atgagaaaag 360 ctcaggatga acaagtttta tattaaaatg tgaaattgta taatacttac caagtttcct 420 gcttttgggg caactgtctt ccgtctattt taatggaaaa aaaattgtta gaggagtaat 480 cggagtatca aaattcaaaa attttacaaa ttattcttat gtctgatttt gaaaactagg 540 aaaaggggaa atcaaccatt tattcttacc tcctggacat ctgaactacc cttttcagg 599 <210> 93 <211 >599
<212> DNA <213> Homo sapiens <400> 93 aaaatttatg aagtatattt attttttctt gctgctataa caaattacca caaagctagt 60 ggttttgtat agcacgaatt tattatctta ctgatctgta actcagaagt tccaagttct 120 gtaactttcc aatgcaggtt tcactgagct aaaatgaagg cactggcagt gctgcatttc 180 cttgtggagg ctttagggaa gagtcagttt ccttgcctct tctagcttct agaggctacc 240 tgcattcttt gactcacggc cctttcctcc attttcaaaa tcagaaacat tgcatctctr 300 tgaccattct tccatactaa aagatccttc tgggcatcac agcatggaaa ggttatttga 360 ttttaaatac ccttgtaatt agattggact ctccccaggt agcctatgac aatctcccat 420 ctgtcaggtc ccttttgcca ttcaaagtaa catacacaag tttcagggat taagacatgg 480 acatctttgg ccatcgcatt ctgcotccca caagtaaagt tgacatcaaa agcacgttca 540 ataaaaagaa acattgaaat aaaattaaat cttttgctct gtcaaagaca ctagtaaga 599 <210> 94 <211 >599 <212> DNA <213> Homo sapiens <400> 94 taaatactta tagaaactat gcttttgaaa tgattttttt aaagttattt tctttgacca 60 ttagttgaag cctactagca acacacaatg tttggagcca aatggttagg cagggcaaaa 120 ccagggggag cctaatcttt ggtcctctgg tggccacagc acctgagaaa ctgaactgtg 180 gcttcaggaa atccactctg gggccacaga agaaagaaca gttgtaccaa ccaaggcctg 240 gcctctgggg accagtacag cccatagcag aaggcaagat gtctgacaca atcctggcay 300 gttccttaaa ctcatgggag ggctggtaac cactggacca gaacagaagc tcctggaggc 360 atctgagact tgtgctcagc tctttccttc cttggcttct cttgctaaga agctcagact 420 ggcactgcaa accatcaatc tctggggcga aatggcaagg tcatcagata tgcatttctt 480 aggatagaaa tgcaggaagg taaaacttca tccaaaacag ataacagttt aagagaaaga 540 tatgggctcc acccccaaat tctgggagcc ctgggcttag gagatgggct ggggaaagg 599 <210> 95 <211 >599 <212> DNA <213> Homo sapiens <400> 95 tttttctgtc attatttctt tgtatctcag aaatagcatg tagctgcatt ttagggattt 60 cttttcctcc tgatttgttg tttttcatga gacaattcaa accattccca tttattgtga 120 ttactgacat gtcaaagctt gtttctgcca tattgtttta tatttattaa tatatgtacc 180 atgctttcta cttttcccca cggttttcct tttttatcaa ttgaccagct cttcttcatt 240 taatttctga ttaagtgctt acctttaaat tttaactcca acatctgtcc attattttay 300 tttcccttat agcctgtgta agtgtagtgc cccttgtcat tatgctcggc aaagcacaaa 360 ccttagccca cttggacttc cttcctctcc ttctcctccc cacctgcaat gttaatacca 420 cttgagcttt tagttccagt tccatttaga cttagcagca aattctaatt cctttactca 480 ccactgcttc ttgaatctgt agctttctct tggatttatt ttcattgtgt tgaagtacct 540 cctcctacag gtaggatgga aggtgactca ttttctcatc tgtggatgtc tgaaattgt 599 <210> 96 <211 >599 <212> DNA <213> Homo sapiens <400> 96 cagaaaggag taagatgata tattcaagac ctagtagggg gaagccaact aagaatacta 60 tacccagaaa tcatgtcttt caaaaatgaa ggattgaaaa aacttcgtca gacaagcaaa 120
agttgagagt ttatcaccac tagacttgca ttgtaaaaat ttcaaaggta gttcttcaag 1BO atggagaaaa atggtaatta gtaacatgaa aatataaatc ttactgataa aagtaagact 240 gttttaaaat ccagtacact ctaacactgt aatgacaatg ggtaagtcaa tcatgtctty 300 agtataaagg ttaaaggtca aaacgattaa aaatgactaa agctacaata atttcttaag 360 ggatacaaat gctgaaaaga tgtaaattgt gacatcaaaa acataaaaca taggaggaag 420 aggattaaaa ctgtagagct tatatatgtg attaaaatca cattgttatc agtattattc 480 acaataccca agatatgaaa tcagcctaaa tgtccatcaa cagatgaatg ggtaagaaag 540 gatgctgtat atattcacaa tggaatatta ttcagtcata aaatataatg aaatccagt 599 <210> 97 <211 >599 <212> DNA <213> Homo sapiens <400> 97 tttcttggcc tcccaaagtg ctgggattat aggcatgagc tatcgtgcct ggccgagttg €0 cctgctttct actgctatgc acagtcacca aagtttagga gctttgcgaa gtcaccaaag 120 tttaggacca tgtgacaatc actgttattt tctgtccaat agggttatct cttctaagct 180 gctgaaacaa ggactgtcac ctgaatattt ttctcttggt ttgtttcatt tggttaaata 240 aaaataagtc aaattagtta aagaaaaaac ttacacagaa tatcacaatt cacatctatr 300 cacttactac atatagacaa gatccaaatt aagagagctg ctaccgacag tgtcagagtt 360 tagggaaagt tcacaatatc ataaagcttg aagactccta gttcagtttt tagacaggat 420 ttttctgatt acatatgcat aatctccttg gggataaaga ataagaagat taagttgtct 480 ttgtctaagc aacacattac cagcttaacc aagattagct gtgttataac aactaagatt 540 atacattcaa gattccagtt tcataattca gatgtcaaaa attgaagcaa acttctcaa 599 <210> 98 <211 >599 <212> DNA <213> Homo sapiens <400> 98 gagtgcatga gacagagacc ttttaagcat gtccttcctt ccccaggttg caactgactt 60 tctccaggga aggaatatat tcccaagttg atcaaatcgt gtggatgcaa gtcttccaat 120 gtgctcagtc aacaaaaatg tctgagcctg ggatgtcagg taacccactt ttcagaatac 180 ttaaatcaca caaaggagca ttctgtttag tactgggacc acaatgctta agctgagcct 240 taagaagtca gtaagaatct taataagatt tggacatgat gcccacagcc ctgatactay 300 gtccaggcag cttaaaattg cttgaggtta aacatttaag ttttataccc agccaacttt 360 ctcacaaagg agtggaggtg atccacactg acatatgtat aaaccataca tttaggattt 420 aacatatgtt aaggttataa tattaatccg aaattaagaa aaacagaaca caaacgctat 480 aggaaaacat aaacatatga acaaagacta gaagaaaaca aaaacctaag tagttgtttt 540 aggaggatgg gattgtaagt aaactcgctt tctcaaaaag gaatctgaat gtcatttta 599 <210 99 <211 >599 <212> DNA <213> Homo sapiens <400 99 ggcagacggg gagtagcagc tgcccctctc tggatcaggc ctgagttctc tggttctcta 60 taatctctac cactccctaa tgtctcatac actggcctgc ttgtctattt gttacctccc 120 tggatcctgc agccccttta gtcagcctgt ttaatccatt ctgcttggca actgaggaga 180 agaaggaaat tatagacagg ttgtatgtgg gtgtccatgt gttaaaatcc ttctgaaaac 240 tcctgatctg gctgctctcc tttccctatg accaactttc cacccagcct tgccacatcr 300 gacctagtag actcatcacc aagatgtgat gagcctagca tcctactccc aaatgaaatt 360 cctggttatc cacacagggc cctcactttt gagtcccata tgctgaagac caggattaca 420 gtggatgcca ggtcagtttc atgtactgtg cccctctcca ttccttcctt attcagcaca 480 tatatctgag tggttactgt gtgcctggca ctgctctagg cattgcactt gtcctcatgg 540 attttacact ctatggggga aagtcagaaa acaaataata tgtaatacat aagatgctg 599 <210>100 <211 >599 <212> DNA <213> Homo sapiens <400 100 gcatgctaag cactaggggc gtcccagtcc tggttgcaac tagctgcgac ccctgttctt 60 ccagggactc tttctcacct cttttcattc ccttctttta tactcttagc taaatataga 120 gtgacttctt gattaattca tctcagttca actaacctct actggaaccc tactctttac 180 tggaaggaga agattcctgc aagggattca cacatgagta agatgtggtc cctaacttgt 240 catattccgc cttagaaggt attgcaattt aatgacataa agcattaaaa tttccacaak 300 aggaatacaa agttctgtgg gaagacagag gcaggagaga gtgattcttg ccagggaact 360 agaagttatc agagaggggc agcactggag cttgtctggg tcccaaagga tggatggaag 420 gatgcaagga ggtcattgca tccaagggac agagagaaag gcatgcaggt gcgaggagct 480 ttgcggtgtt taaggcacta ggaacagcct cataggcJctc aaggggtgtg tgatgaagaa 540 tcggaaataa gacctagatg gtgggctgga ccaggtggta gagggatttg aatgctttg 599 <210> 101 <211 >599 <212> DNA <213> Homo sapiens <400 101 tacatctatg atataatcca aacctgtgag tataatgtta aatgcaagta gaacattttc 60 tctgattata ttattttagg ctgaattaaa acttgcaaat gtgttaagga tgaataatga 120 tggcttaata tatcacaccc ccaaggcata tgcacttcac aggggcctgg ggcccaactg 180 gcagcagaag ggaagaggga taaaagtgga ggcacaggcc acgtgcacct catccatcac 240 ccatggttat taattgtctc ctcagctgcc ctgacaaggc tcttcctggg gctttctgcr 300 ggaggcttgc aaggtgaaag ggaaggtttt tatttttatt gctgcagaat tgaggatgat 360 tctttaaaga tgacgcatta aatcaggaga gacacattaa caaggggagg tccggagtcc 420 accttgcacc cctgggcagc tctggccctg caggcattca ctctctctgc actccctcct 480 ccgccaccag gtagaggtgc taacactcac tccctgacag gctgtgagta aacaggtgac 540 tcaatcttta acccttgctc agtgggttaa gaaattagtt aattattcac atcccactc 599 <210 102 <211 >599 <212> DNA <213> Homo sapiens <400 102 gagcagcctt ggcttccggc tcatgcactc acgatgctgg ctgcgaatgg gaagtcccta 60 aacagaactg agccccctca ttcagctcag agcaaacggg gctggcagca gcccagggca 120 ccacgaagca gagtgcctct gtgtgcccaa cacagccgca gtggaggtca atggatgtcc 180 ttgccggcgc cctgcttttt gcttttttaa gaaaataaga agcctgcagc tgcggcaagg 240 agaaagaccc cgtgggtcgc tccttttaga ctacgctatt acacctgctg actatccaay 300 agaaaaaaga aggagaagga aaatcgggtt aactttctgg tatttagttt gcagatatgt 360 cagcaggcca ccttctctac ttggcaggat cacgatgtat taagaatcct tttgtccacc 420 aggaaagaca aatttcctgt ttgtcttgca tttagatgca acaacatcat cctaaagaga 480 tgcccctgat gtgtgagagc agaaaggggt gatccctttc ttccttatcc taaggctcac 540 ggccaacacc cctataacaa aagacaggtt aacaagagaa aagcatgaca aatttattt 599 <210 103 <211 >599 <212> DNA <213> Homo sapiens <400> 103 aagtacctga tgtctggctt gccatgggat aggtaggatt catccatcct aacttcccac 60 cctaactgcc cccgtgtctt tttgtgcagg gggcccagaa ggttagtctg ggcacaactg 120 gccttcctca gtgccgtaga aagggtggta cactggggoa atatttattt acattgcaga 180 gaaacctgat aagaggttga gaaatacttc tgacattaat tataatatat taccaggtta 240 tatggattaa atgatcagat tacactccag tcatgcttct gaatatgtaa gcacccccay 300 aaaagaagtg acaatttccc aagatacctg gactcaaacc gtagggtgtc tacccctcct 360 ctctgtggtt tctttccctg agttgctcac tgcccatgtg gcttctctgt agggtctgtc 420 accttatggg attgatttta tggcagctgt gctgtgactc gtgcatccac agaacaatgt 480 tgaatgactg tgtaaacgca ttgctgtaag caacctgagg tctgaacttc tccttatctg 540 attgttccct ctaagtaatt tgtagcaaat ttcaacattg tttcccattg gccagcaaa 599 <210> 104 <211 >599 <212> DNA <213> Homo sapiens <400> 104 ggaggccaag gtgggaggat cccttgagcc cagtagttca agaccagcct gggcaacaca 60 gtgagaccct gttcctaaaa aaatttaaaa aattaaaaaa ataaaaacat gccacaggac 120 cactgctcag agctctttgg tctggcaacc ctggaccttc acatggtttt gtttgccaaa 180 gcaaagtcct tattaatatc caaatacagt ttgagttttc ttgggcttta tcctctccag 240 aaacccagga gtgtgtcaac ttcttggttg cattgctttc ttcaaagaga gagtgaatcy 300 ggtagagata gaaaggatgt cctttacgta tcccacagcg gcctcacgga gaacgataag 360 agaacaatca ttaaaacttt cattgccata attttctgct ttcgtttttt aaaagtttgg 420 gttagcaacc aatttcctcc ttgaccaggt gattttttcc ttagactgtt tatccagagc 480 attaaggaaa acagagcata ccaccctccc accatagctg ataaggggat tcaacacagg 540 tgcgtgtgct agagttaagg gaacatatta tgctaacatg aatctagact gacttaaaa 599 <210>105 <211 >599 <212> DNA <213> Homo sapiens <400>105 ccatacactc agcaagaggg ccatggaaac ctggctatta aaaggactcc cccatggagc 60 acagccctgt ggaaatctga gggtgcatta aagtaaaaca agtcaatgct catcagaact 120 cccttccaga ttccaaaggt gactggagtc aacaagcagt tatccctgtg tcctcccctg 180 atgtgggcag ctgggtccat gaaataagtg ggtagctgca gcagtgcaga gatgggctga 240 atctagacat gttctgtata gacgctgact ggtctgggct ttgcttaccc ggtggaggay 300 gcaaatgctc actgtgccat tcaaaagcca gaacagaaga tattgcacca atttggatgg 360 cccagtcaca tttctttaga ccaaggaaca cactttacag cctgtaatat ccaacaatgg 420 gcagagctag tctcctccgg gtaatagttt gatagaaaag tagaacaggc aattcaaaca 480 ttagttgtcc taaacggggg gagatgaaga cacgaagggc tggcttgcac atcttcacaa 540 gtgtagtgca cactcaccat gagtggggct aaaggcgtgt tcccctaaca ctttcctcc 599 <210>106 <211 >599 <212> DNA <213> Homo sapiens <400> 106 caaatgctca ctgtgccatt caaaagccag aacagaagat attgcaccaa tttggatggc 60 ccagtcacat ttctttagac caaggaacac actttacagc ctgtaatatc caacaatggg 120 cagagctagt ctcctccggg taatagtttg atagaaaagt agaacaggca attcaaacat 180 tagttgtcct aaacgggggg agatgaagac acgaagggct ggcttgcaca tcttcacaag 240 tgtagtgcac actcaccatg agtggggcta aaggcgtgtt cccctaacac tttcctccgk 300 ttcctggtgg atctggggta gaggggtggg aggatgctgg tatgactatg cagttcttgc 360 caagggagaa gtacccaggc ataatgactg caattttttt tccttccctc tccacatcac 420 gttaactttt tttcccctac ctgatgcagg ggtcataggc ccagggctgc aattataaat 480 gctgacagca gggatgattc ctaagcagga aattgtcact atgtttttaa aacttgtgtc 540 agaattccca agggcctgat ggggatgggt tgtgccttca ccccatctgg caaactggg 599 <210> 107 <211 >599
<212> DMA <213> Homo sapiens <400> 107 gcccttataa agagacttga gtgagcttcc tcgcccttgc tgccatgtga gaaggcagca 60 acaggacacc atctatgaaa cctcacaaga cccttaatct gctggcatct tgaccttgga 120 cttttgagcc ttctgaactg cgagcaatac atttctgttg tttatgaatt ggtcagttta 180 aggtattttg ttacagcagc tcaaacggat taagacagag cccaaccaaa cacccgctcc 240 ttggatcgct cccctccttc cttttgttgc ctctcccctc attaaggaac gggaagggar 300 agatgaggga taaacaagcg tggtgacgga ttggtcctag actgatgcgg atgacgtatg 360 catcagagat ttcctgggcc ttgctctgac tttggtcttc cagcagtgcg caggcctgct 420 ctgccccgct ctgccccgct ctgctggcct cagccttcct cattcatcat tgttcacctc 480 actcccatcc accttcttcc ctttttccca aacctatcct gatgagaagt ttgaattctg 540 ttttaaggaa agaccttcca atgcagtgtg gagtgagggc cattcccaca tacatacac 599 <210> 108 <211 >599 <212> DNA <213> Homo sapiens <400> 108 tgtgctgaca tttttgaaag ccctaaaata atttggtgcc catagtggga accttgtcat 60 acttatttac atagtatgga aggctatttg acaaaaaaat caaatgaggt ataggaatag 120 taactcatta taaattgggg acaataaagc caaattccac tggattttaa agttatacaa 1Θ0 atgattctct agtccctaaa ttagggatat aaaagtccgt aggcagcttt ggggctgaaa 240 ggggttctgt aagcatcttg ctgtataatg gagcaagtcc tgacccagaa aagaatctgy 300 actttgtccc agatgggcta taacttgctc tgtgactgcc atcatgtgtg ttctggcaga 360 gattcatagg caggcagagg agtggggaag cttcatagca gaaaagggaa ggtgtcaggt 420 gtgtgctgac tggaggctgc tggccgggga agctggaacg aagtgggcta tccagaggtg 480 gtgtatccat cctctgtagt tggttagggc acttagttca ctctctccag ttggggttga 540 ttgtagagtt ctaacttttt acgtggtctg gccattgtcc atgtgtatat tcagtctct 595 <210>109 <211 >599 <212> DNA <213> Homo sapiens <400> 109 aacgggtggg tgagttatgt gctggcaaag gcaggtgtgt ccacatgcgc gagcagacac 60 tgagactgca gcccacacac ccagaggaac aagcaggaca tcttaggtta ggaatgtgcc 120 tgcagctggc agtgcccagg agagggactt ttctaactgt gttgtccagt gccttagtcg 180 ctaaccacat gtggctgcat aaactttaaa ccagttagaa tgacataaaa ctgcaaatgc 240 agtttcccac ttgcactagc cccattctaa gtctccatag ccacctgtgc ccactcgccr 300 ctgctccagg agtacagatt ccagacattt cagccactgc agaactgtct cttgggtggt 360 gtctgcaggt gcctgctgca gctctgccag gcaaagtaga gtggctgctt ggctgcctat 420 ggatttagat gatcctgcca acatctgatc agttgctctc agcacctgag cttcatcatt 480 aggatggatc tggggcatgc agggagaatc ccagactgtc agagaggtgg cctggcctgg 540 ggtgaccagt caggcctctt gtccttatgg tcacattctc agaattgggg ccagggatc 599 <210> 110 <211 >599 <212> DNA <213> Homo sapiens <400> 110 taatttcttt ttaacaacaa agtcttcatt tttaagacat tttttaaaag taagtcacta 60 tggattttat agatttctgt ggtttaagta aaatgtgttt caacatagca taaaacctga ' 120 agaagaaaaa tacagagttc aactattata catacttgta ctatatgaaa gtcatatacc 180 atttgaagta cgtaactatc agccctaaag aagccactaa aatagcaaaa gcctctatct 240 aataagtcaa caaagcaaat taaatgaggt attaaaaaaa ttaattcaaa agaagaaagr 300 acataaggaa aaaggaaaaa aaacaggcaa aacaaataga aaacaaatat caaaatggta 360 gactttaatc taactatata attacattaa atctaattaa atctaaataa agctaaataa 420 atctaaataa aaaatctaat agatctaaat aaagctaata aagtaaaaag gcaaacattg 480 tcagagtgta taaataaagc aaaactcatt taaatgccgt ttataagaaa tgtactttaa 540 atataaagaa acaagcaggt taaaatgaaa aggatggaaa aagatatgac atgctaaca 599 <210> 111 <211 >599 <212> DNA <213> Homo sapiens <400> 111 caggccattt tcacttcttt tgtggtggaa tgtcaccagt taaggcggga accggtcatc 60 tggatgtgta catgcaggtc acaggggata tgatggctta gcttgggctc agaggcctga 120 cataaagtaa taaaacttct aaaaaaaaat acttagcacg atgaggtcct gaggcacgga 180 aatatttaga cattttaaat agatattcaa caatgctgta agtaactggt agaatttcca 240 taccaggtct cttcctatgt cactagccca tgggcacaag aggtcatgaa agaggaacar 300 aaataggaaa acctgcatca acacagaaac agcctgttct ttgccagaat ggagaacaag 360 gcaaagctgg tacttttaga aagctgaaaa tttgtgccaa tgattttttt cctagcttat 420 ttttggcttt ttgattctaa ggagttttga cctacaaaga tgctcaatat ttaaatagac 480 agatattttt gttttatttc ttccattgct tttatacttc ggcatcctcc ttactgagat 540 gagataaagt tttcaaaaac attgtatgga attattttct atgtatcatt atttaattc 599 <210> 112 <211 >599 <212> DNA <213> Homo sapiens <400> 112 ggcacggaaa tatttagaca ttttaaatag atattcaaca atgctgtaag taactggtag 60 aatttccata ccaggtctct tcctatgtca ctagcccatg ggcacaagag gtcatgaaag 120 aggaacagaa ataggaaaac ctgcatcaac acagaaacag cctgttcttt gccagaatgg 180 agaacaaggc aaagctggta cttttagaaa gctgaaaatt tgtgccaatg atttttttcc 240 tagcttattt ttggcttttt gattctaagg agttttgacc tacaaagatg ctcaatatty 300 aaatagacag atatttttgt tttatttctt ccattgcttt tatacttcgg catcctcctt 360 actgagatga gataaagttt tcaaaaacat tgtatggaat tattttctat gtatcattat 420 ttaattcata tggaatttat taagggcatg agataaaaaa taatatttct tccaaaagga 480 aagacaactc tctcagacca ttacttaaaa aaatccccat tgatttgtga agccactttt 540 ataaaacatg tccttttggt gtatactatg atttgttgat gggttctcag ctctgttct 599 <210> 113 <211 >599 <212> DNA <213> Homo sapiens <400> 113 agggacagag ttatttccga 'ctggttgcag atggggagaa aggtctatgg tatctgttgc 60 tgatctctgg gctcacatca gacactttgc aaatctggct ctctccaggg gatttgggta 120 acagccctgc ctttcagagc aaataacagt atacactcgc agagctcgtt atagcagttt 180 tggtgggttt agggacgcaa gttcccagcc gggactattc ctgtggagtt ccctgagtta 240 caccctccag gccacgcccc ctggccaaac gtgagtctag agcagagagt ttccatgtar 300 aggcttcatc tgtttgtatt ggctcattac agacactcct tgagatttga ccaatgcaac 360 atgtggcccc atgctagcgt gctatgtgct gagacaacag cttagagcaa cagctgggga 420 accttccctt ctgcctctgt tctgaaataa agcacgtcca tttaagacaa agggggctat 480 gctgaaatga cttatgggga aaattacagg tcacaaaatg taatgtgact ataacatatt 540 ggaatgttga tgactgctcg ccataaagtg gtcaccaatg tttctttcac cccccaaca 599 <210> 114 <211 >599 <212> DNA <213> Homo sapiens <400> 114 taataaaaaa aagtaaggtg attgatatgt taattagctt gattttagta atcatgtcac 60 gatatatatg tgtctcatca tgttgtgcac tttaaatata tacaactttt gtcatttcta 120 tcttaataga gctgtaaaaa ataaaaatat gaagcaaggg acagtgttca ccagctcata 180 atggatagaa agtatacctt atatttattt ttatgctaga ggtttattca gttattcact 240 catgccttta ctgaaaacta ccctcttcta ggcatagtgc tgggaactga gcacacaccr 300 atgaatatgt cacagcccct gtccttggag accttcacct catggtctag caacaggtga 360 acaaaaaaaa aagcaatatg ggcattcagt aaatccctga ctggtatgca aacatgaggc 420 cagtgccccc actggatacc cctccctagt aatgtagaat agtgaccttt tcaccacacc 480 ctggctaaag cttctagaaa cacacacaca cacacacaca cacacattta gaggtacaga 540 ctgtgactat ggaacaattc agtgtaacgg ccacatgagg aaccgatgtt tgaccttaa 599 <210> 115 <211 >599
<212> DNA <213> Homo sapiens <400> 115 tctacctaat actctgtaac tatctccaaa aagttaaata aatcagatca ttaactagag 60 aggcctttga ggctaagtga cttgcccgag tttgcaaatc ttgttcagag aagaacaggg 120 accagttccc agcacctggc tcttcctgcc aggattgatg atattgaccc caetgccctc 180 ttgtcatggt tcctgaaaaa aactcctctg attaatgcac caccttaaac cctactagat 240 gatttcagaa tccaaccaga tgacacctct tagataaagg gctctcttag agatcggctr 300 tcggggcaat cgttttctag aaatagcctc tgcccagaat agatggaagt ctttcaagct 360 ggctattttc taaggtagac cctttctgag gcctttgaag ttactttgca gctgcaaatg 420 gctgccctat ggacagaata ggactagatg tctaataatt ccagagcagg cctgcacagt 480 tatctcaaag cacagtgccc caagtgaaca ttttcttagc ataaacatcc tattccttaa 540 tatgttatta cttccagcaa acatagattt cttaagttct ttcaatttga gataaagtg 599 <210> 116 <211 >599 <212> DNA <213> Homo sapiens <400> 116 ctgagcccag ttagaaagtc agcacggcac acaagcattt gggaagttta ctttagattc 60 ttccacagat atcagtgtgt gagttaacca attttaaatt atcctctatt taacatgttc 120 ttattacaaa tatttgtatc aaaaattcca atcagatgta ctttgcttca ctacctttag 180 tctacaatta ttgatcttaa tcactttgat gccagtcttc aaccttggtg gtcagcacat 240 gacttctggg ttttatgaat ggccataaaa ccagacacag cgtgtccagc tctgtgtgty 300 aggaaccaag ataaatcatg atcttcgcag ggttcagttg gctcttctgt taaatgaggg 360 gacagaccag attcgtttgc cttcttagtt tcataattct acaattttaa ttctattcaa 420 gttttaaagc ttctagagct tatagtataa attcaggatc taaagctaat aacaaagtat 480 aaaataaaga tctcttgtta ccacttccct atcttcagtg accccttgca aagaaaagac 540 acatcttttt attttcagag atctcactaa agtgcactgt aaactaaaga gcccatgaa 599 <210> 117 <211 >599 <212> DNA <213> Homo sapiens <400> 117 tgatgtttgt gagggaaagc atatgttaat cagcttgatt tagccattcc acaatgtgta 60 catatgttaa aacagcatgt tgtacatgat aattatatac agtttgtatt tgccaattaa 120 aataagattt ttttaaaaag tgtaactcaa atgtacctgt tagcaaagag ctgagaggcc 180 ctggaggggt cctgggaagc aagagacctg ggccaggagc ccaaagcccc ccaeccccat 240 acacattcct gccatcaatc ccttgtgtta cattggacaa atcacttttt ccctgagccy 300 gttttctcct gtctaaaaga gagatgccac ctgtaccctc acttccctcc cccgccttcc 360 ttccatcctt tctttcttca tccaagcatt agttgagctc ctggcaaata ctggcctggt 420 ggcccagaca tgagttactc tgtcttctgg atagcttcca cacccccacc aactttattg 480 gatcattgtg ggggaataaa tgataagaca gaggtgatgc tgttcttttt aagaaggtac 540 ttcccaggca tgaggcatga ttgatctttt tacagcattc ctgatctaaa ggcaggatt 599 <210> 118 <211 >599 <212> DNA <213> Homo sapiens <400> 118 aagacaacaa tcctatttta aatggctacc aaataattgg actaaattta accaaggagg 60 taaaagatct gtatgctgaa aaccataaaa cgttgattaa agaagttgag gaagacataa 120 ataaatggaa agatatctca tgtttatgga ttagaataat taatattaat atcaatttat 180 gaataaataa aggtttgtca cctttattgc actgaggtac attcatttat actaaatttg 240 ttaagaatgt ttatactgaa agttaaaatg tttatactac ccaaagccgt ctattgacty 300 gatgcaattc ctatcaaaat tccagtaaaa tttttcacag aaatagaaaa aaaatcctaa 360 aatccatatg gaaagcaata gaccccaaat agccaaagta atattgaggg gaaaaaagcc 420 agagacatta tatactacgt gacttcaaaa tatactataa agctataata gtcaagacag 480 tattacactg gcataaaaag agacaatgac cagtgaaaga gaatagcaag cacagaaata 540 aatccatgaa gttagtcagt tgtttttttt tttttttttt tttttttttt gagacagag 599 <210> 119 <211 >599 <212> DNA <213> Homo sapiens <400> 119 tcacctgagg taaggagttc aagaccaacc tagccaacgt ggtgaaactg catttccact 60 aaaaatacaa aaattagcca ggcatggtgg caggcacctg taatcccagc tacttgggag 120 gctgaggcag gagaattgct tgaacctgag aggcagaggt tgtagtgagc cagtgcactc 180 cagcctgggt gacagagtga gactcatctc aaaaagcaaa caaacaaaaa gtgaaaaata 240 aaaataaata tttattttaa aaaagaagag agatctcaaa taaacaagct aacatttatw 300 tctcaaaaaa ctagaaaaag gagaacagac taacccaaaa gttagtagag aaaaggaaat 360 aataaagatc acagcagaaa cagaagaaca agaaactaga aaaatgataa aaaagagaaa 420 caaaactaag aaataatttt taaaaagata attaaaatgg acaaacttta tctaaactaa 480 gaaaaacaga atactcaaac aaaatcataa atgaaagaga aaacactata atagatactg 540 aagaagtaca aatgatcata agagactact ttgaacaatt atataccaac aaattgtat 599 <210>120 <211 >599 <212> DNA <213> Homo sapiens <400> 120 tggctgagtg gaactcttgt ctctcagtat tatactacct tcatcttctc tgttaagtgc 60 acagcttaac agaactccta cttagacagg cctcatagaa cctcattctg ttcagaagca 120 agtgtttctc agccaaagat tccatgatct atgaagattt ttacaggcct atgccagtag 180 atcccagtgc tgggccagcc ccccagacct catcccttgt ggacctaagt ttcaaaccag 240 cctctacagc ccgaggatct aggttagccc tcatgaaccc accctccagg ctggccccar 300 tggaccaata caccaggcac accccaatgt atccaagccc caggaccatc tcagtgccca 360 gaaagcccct gcagactaaa gcttaaggcc cactccagtg ccaggtcagc tcttgtggac 420 ccaggcttca ggccattccc tccagggctg cccttctgga cccaggctcc aggcccaccc 480 catagaccca gtcaacttgt ccccccagtg gatccaggat gtagacccac cacatgggcc 540 caggcaccag gtcagcctgc ctgaagattc cagcagtaaa gtttcttaca aactatacc 599 <210>121 <211 >599 <212> DNA <213> Homo sapiens <400> 121 gtctgtcatt attcttctag ttgttcctgt agggattgca atataaatcc ttatcactgt 60 ctacttagaa ttaaagttgt gccacttctc ataaaatata aggactttga agtattatag 120 ttccacttat taccatcctt agttatatta ttgtcatatt tatcatatct aaatacatta 180 taaatcccca atacagtatt gtctttttaa aaattaagag aaataaaaaa ctgtgtaatc 240 ttcatatgtg ccatatactt actatttctg atgctccttg cttgttcctg tacttctacw 300 attacatttg gagtcgattt ttttcagcct gaataacttt ttttgctatt ccttataatg 360 tgaatctgct ggtgactgat tctattttca ttcacctgaa aaagtctgta tttcatcatc 420 atttttgaat gaaatttttg ctaggtacag aattctgggt tgaaggttgt ttttattccc 480 ctgaacttta aagaagtttt tttcaaagta ttctccctcc attaattctg atgtgaatca 540 ttctgatgtg agtcattatt catgttgttg cttccctgta gttaatgtgg tttctcact 599 <210> 122 <211 >599 <212> DNA <213> Homo sapiens <400>122 atctccatct gccatctatt acctccatct accaactcca cctaccacca gtgatgaggt 60 cctcattgcc agctgaataa gtgagtgtgc cagctccaaa actctattgt ttcacctgct 120 ttcttagtac attcctgcta ttaactgtta cagattgagt tctctgggaa agtctctgag 180 aaagaatttt gcataagtgc ttgttcaaga gtgtccttga gattaatgcc tgaaggaggg 240 agaaaggaaa aggaaggaga atggggcaga gagagaagtt gagctgtaac aggggcccam 300 cagtaacacc tgaagaccca cagagacctc tggagctaca gtggcttttc agagttgacc 360 tcagttgggc caaaatggtc agacattata ttttttttat tgttctctca tttaatgtgg 420 gctgcccaag gaaggagtgg gcaagacgcc tttctgaagc taacataatt actgaagggt 480 ctgacagtag aagacatcag ccaacaacag tccctgctgc taggtcaaca agtctttcct 540 tagagggatc tagaaggcac aactcagtgt tcatcagttc cttcactgga ttttcagct 599 <210>123 <211 >599 <212> DNA <213> Homo sapiens <400>123 ttgtaatggt gaattttatc tatgttaaac aacaaattta aaaaaaatat ttggaggaac 60 attgacccgc ttgccccact ccatgcgtcc cattgagcac cctgactttg gtataacaga 120 cctgccttga ttgggcattt agcattcttt aaagcttggc tactctgaat taagtctgag 180 gtcttatcct cagctctgtc ttttctcatg ctgcagatgg gaaagtcttt gtatgctacc 240 aaggtttcca cttgcttgtt aatcaatctc aagtctttgt tatacttttc tttgaaatgm 300 ctgatgtatc atgtcatcca catttcagca catctcttca ttatactatc tcagtttccc 360 actagagaag tgaagccatt agacttcact tcttagtctt atactagaag ctatctccat 420 ctgccatcta ttacctccat ctaccaactc cacctaccac cagtgatgag gtcctcattg 480 ccagctgaat aagtgagtgt gccagctcca aaactctatt gtttcacctg ctttcttagt 540 acattcctgc tattaactgt tacagattga gttctctggg aaagtctctg agaaagaat 599 <210> 124 <211 >599 <212> DNA <213> Homo sapiens <400> 124 actggcatat ggataaatgt gtagaacaat ggactagcac cgaaagtcca gaaataagtt 60 tatatgccta tggtcaattg atttttgtca agggttccaa gaccatttga agatggaaat 120 aataatcctt tcaacgaatg atgctgaata tctacatgca aaagaataaa tgtggatccc 180 tgctttacac cgtatacaaa aatcaatgca aagtgggtca aagacccaaa tattagagct 240 gaaactataa attcttagaa gaaaacatag gtacaagttt tagtgacctc acacatgcar 300 caacatgcat gaacctataa aacattatgc taagtgatag aagccagaca caaaatgcca 360 cattttgtat gacttcattt ctataggata tccataatag aaaaatctgt agagacagaa 420 agtaaatagg caatttccag aacgtgggag aaggagggaa tggggaggta catggtttct 480 ttggggtatg atggaaatat tctggaatta gataatgata tggttgcaca ttttgtatat 540 aataaaaacc actaaattga agaatttgac attgtaatgg tgaattttat ctatgttaa 599 <210> 125 <211 >599 <212> DNA <213> Homo sapiens <400> 125 atacaagatc agcatgcaaa tatcagttgt atttctatac agtagcgatg aacaatccaa 60 agataaagtt aataaaacca ttcagtttat aatagcaaca aaaagaatat ttgggaataa 120 atttgaccaa ggaagtgcaa gtgttgtaca ctgaagacta caaaacatta ttgaaaaata 180 ataaagacct aaataaatgg aaagatgtgt aatttcatgg attggaaaac ttaataatat 240 caagatggca atatatgcca aaccgatcaa cagattccat gcaattcctg ccaaaattcy 300 agtggctttt tttttttcag aaatggacaa attgattcta aaatgaacaa gtgacaccaa 360 atagccaaga caatgtttaa aaaggaagaa aattggagga ctcacacttt ccagtttcaa 420 aacttactac aaatttacag tatttgaaac aatgtgatac tggcatatgg ataaatgtgt 480 agaacaatgg actagcaccg aaagtccaga aataagttta tatgcctatg gtcaattgat 540 ttttgtcaag ggttccaaga ccatttgaag atggaaataa taatcctttc aacgaatga 599 <210>126 <211 >599 <212> DNA <213> Homo sapiens <400> 126 ttattgtgtg aacttgctgt gatgttgcag gattcttcct cctggagccc agatactttt 60 caaaagatga atgtcatttc tggtaaaaat aaaataaaat aaaaatggca ttgattcagt 120 aactgctcaa ggaatcataa cactgtacga gggcaattgc tgtcaacctc ctgatcatct 180 atccttgttt tgttctttgt tttgttttgt tttttgtaca gattgagtag taaccttgtt 240 ggcagctcat ttattttgcc cctaaacatg ccataatcta ttaggggtct aactctcagr 300 taatcaggtc cccgactgtc cctacaacct tgccgtttac tgtggcaact gcatgtacca 360 atgcattcct tgtggcctgg aaatagtgtt ctcttgaagt ttcccatgaa acacaggcat 420 ttggtgggtt tcccagtctt acaaagtcta tgccctcccg caggctcact tctctgagcc 480 ttttaatcct ttttcccact ggcaaccatg gtaattctgg aatttcaacc tcacttggca 540 tggaccatta ctgtttctag gctcctagga gccatcccag tagtgagttc acactgtat 599 <210>127 <211 >599 <212> DNA <213> Homo sapiens <400>127 caacttcgac ccagtgtcca acaatccttg acatgtttgg tattctcctt tccgtagtgt 60 acaattaccc aagtaactgg ccataaatcc ctttgcagaa agactggggt aattattatt 120 gtgtgaactt gctgtgatgt tgcaggattc ttcctcctgg agcccagata cttttcaaaa 180 gatgaatgtc atttctggta aaaataaaat aaaataaaaa tggcattgat tcagtaactg 240 ctcaaggaat cataacactg tacgagggca attgctgtca acctcctgat catctatcck 300 tgttttgttc tttgttttgt tttgtttttt gtacagattg agtagtaacc ttgttggcag 360 ctcatttatt ttgcccctaa acatgccata atctattagg ggtctaactc tcaggtaatc 420 aggtccccga ctgtccctac aaccttgccg tttactgtgg caactgcatg taccaatgca 480 ttccttgtgg cctggaaata gtgttctctt gaagtttc.cc atgaaacaca ggcatttggt 540 gggtttccca gtcttacaaa gtctatgccc tcccgcaggc tcacttctct gagcctttt 599 <210>128 <211 >599 <212> DNA <213> Homo sapiens <400>128 atttcttgtc atccagcccc attctcacga taccactgat aaaatgaatc aaaggccagg 60 acattcaaac agtccagatc tctttggact atattgtaac agagggtggg taggacaaag 120 aactaacagg tctgggacac actgcaaatt tacactgtta accatttcag ttaaaattta 180 cactattaac catttcatgt gagtgcaaat ggtttctcat cctcttttct gcaaaggatg 240 tgaaaaaacg tatttgccaa atcaatagcc acatgccatg cccctaaggc tgtgttgacy 300 tcttctaaat atatcatatt ctgcagggtg agggcaaggc ttgctactac ttgcttgagt 360 tggtggtagt ctactgtcat cctccagggt tcacctgggt tttgcagagc ccagcctggt 420 gagttaaata aagatatgat gagaaccact gtactgcact ttttagatct ttaaggaggg 480 gattaatttc catcatcctc ctcaggggat acaatattga tttttatata ctatctctgc 540 tgaggcaagg gtgggaggga accatttcag gagctttcct ttgggctcct acccaatag 599 <210> 129 <211 >599 <212> DNA <213> Homo sapiens <400>129 agaaaaccac ctggtatgag acaaccacct ggacatgagg cagccacctg gacatgagat 60 agccacctgg acacaagaca cctggaagga gacagccacc tggacagtag atgagagttt 120 tggaaattat ttgcctgtat ctttaatttc ccttttttca ttagaattta aacatggcct 180 ctgctcaaag aagaaaaaga aggaggaatg aaggaaagaa ctgaaaagaa agaaaagaag 240 aaggaagaaa gcacatcttc ctgcaactac cacttctccc cttgccctca ttaccccacy 300 gtgtccactt accctgtcct caccatgcca ctatcttgac acgattgttc aagacctcct 360 tctggcaagg tcattacttg tatccctggc agtgtttcat gccattgaac cttcctcctt 420 aaagaatgtg caaccactct gtgggccact ttcttccctt ggcttctgaa cggccccaaa 480 gcccactcct cagacatctt agtgggttct ttttccctct gtccactcct ctcactcggg 540 cattccatgg ggttctgtcc aaattgctct cctacaaact ccccttgggc aatctccac 599 <210>130 <211 >599 <212> DNA <213> Homo sapiens <400> 130 tatattttga gtttatgaca tgttttataa attgattatt tttttctcaa ttaggaacat 60 ctatgcttat ctaagagatt ccctttattt tatgaggttt atattctttt tggtagaaaa 120 cattttgttc caccttaact gtttgaggat taataaagta agatgtataa atgttattat 180 tttgatttct taattgaaat gtaatttaaa gttgggtctt gctgcctttt ggggcttcgt 240 gccgggcacc tgaaggaaag acaaattaaa ttattctcca acgtgctctg gatggtgags 300 ctcaaacctg aatattttgt gttttgaaat ttgagttttc agagtcagaa atttagagta 360 tatccataca gatatcctag aataaaacat atacttctta tttaaaagta aagtttaaag 420 atactttatc attgaaatca tccatccatc tagttgattt ctacaggtga gctagcataa 480 ttaaatcatt ttcctttcat ttccattaat attggctttt ctgaaaggat aacaggaatc 540 tcaaattctg ttatagagct gatatttaaa agttcaattt cgccattttt ccaaaccca 599 <210> 131 <211 >599
<212> DNA <213> Homo sapiens <400> 131 cctttcaact gtgaaatctc taaccagacc atcaccaatt ataaagcagt ccccagcctt 60 accatggatt aagtagaaat taaagatccc aacacacata tgtattgcct ggctgtcttg 120 ccaggggggt ttatcctgag atcactcagc atagagccac tcagtgtgcg aacacacttg 180 catgtggcat tatagaaaca ccctgaacac acatacacat tgcctggctg tcctgccagg 240 gggttttatc cctggagcac ttagcataga gccatccact gtgcgaacac agcagcacay 300 ggcgttacag aaagatccca aacacataca cacatcgcct ggctgtcctg ccatgggttt 360 tatccctgga gcacatagca tagagccatc cactgtgcga acacaccagc acatggcgta 420 taaaacatgt acaattgcaa ccaccgacac tcccaactgc agcgagataa gctcaccaga 480 ccaacagcaa cagcggcaga aagggcgctc ctacctcctc atccagtgtt ttccccactc 540 ttcaagtagg tgatttttta aagtttatca caaaaaaaag acaaaccttt tttcctaat 599 <210> 132 <211 >599
<212> DNA <213> Homo sapiens <400> 132 gtagcttggg cttcctccta gcatggtggc tgcagacgtc ttacaaagtg gttcagagcc 60 ccacaggtgt gttctataat agctcacaag gcagaagctg cattgccttt caggacctag 120 cctcagaagt cacactgcct catttctgct gtattctgtc agttccagga gagtcacaag 180 cccttcctgg attcaaggga aagggaatta gatgccattt cctgatgaag gtggggcaaa 240 gttttgaaag agcatgtgtg ggggactcat gccatctttg gatagtccca gtctccctcs 300 tcaaggacat caactcttgt agtttgtctc cagtccaaac atgtgtgggc actttccctg 360 catatgtggg tatccacgtg aatgtctctt cattgcttct ccatctttct aaaaagtaat 420 cacagagagt catgaaatcc agtgttagaa ccaggcattg ttaatgctct tatgttatta 480 ttattcaagc tgggctaggg gaatgtggca ttaataaaac aatatgtaca ttggatttag 540 ttatactata ctctctattc taatactttg taatcattag taataaatag tagcatatt 599 <210>133 <211 >599 <212> DNA <213> Homo sapiens <400>133 agaacacatg gactcaggca ggggaacaac acacaccggg gcctggttgg cgtgggggca 60 ggggggtggt gcggagaggg gtgaggggag ggcgaacacc aggacaaaga gctaatgctc 120 gtgggtctta aaatatagat catgggttga taggtgcagc taaccaccat ggcacacgta 180 tacctatgta acaaacctgc acatgtatcc cagaacttaa actaaactaa aatttttttt 240 taagtgaatt ttagccacta gattttagag ttgaagcatg ccatggtact tgtgattagk 300 catctacctg tgtatttatt cacctgaaca cctggatgtg tagaataaaa attgctcaat 360 tgttgaaggc tgctgcatcg ctctatgcta cttgttctgt taaagtatgt tcagggagcc 420 agcccagaga ggcacctcct tttagctctg tgaggcctta aagctgggtc accatgaagt 480 ccctgtatat atattttttg ttttaataac tccaagtaac caaatgaaaa caattattta 540 taaaatgtat taagaagtaa atgttatcaa tttgggactt tgcacaacta ttattaatg 599 <210> 134 <211 >599 <212> DNA <213> Homo sapiens <400> 134 atatttaaat tctgtaggct agttttcata ttctggaaag gtggattttc atatggcact 60 ggtgctggtg tttcatcagg tcagctgtct atgtcataag agggtgttct tattagaaaa 120 tgtaggcttt ggcaagcttt aaaaggtaca cgtgttactg catgttctga cgagattttg 180 aaaatctttg gcaactgtgc tttccaagtg gagaaaaagg gctaccataa tgttgaaaga 240 cggaaattaa aatctaatca gatatggtgg cccttatcct ccaccttaga atttctttty 300 gtggaatgtc tggtggacag taatatatag aggctcctcg acttaggatg ggatcacatc 360 cagatacacc cattgttaaa ttgaaaatat cataagttga aaaatgcatt taatatacct 420 aatctaccag acatcatagc ttagcccagc ctactttaaa ttgctcagaa tgcttacact 480 agcctgcagt cgggcaaaat tatctaacac aaagcctatt ttgtaataaa gggttaaata 540 gctcatgtaa tttattggat atagtatcag ttgtttcccc ttgtgatcgc atcactgac 599 <210>135 <211 >599 <212> DNA <213> Homo sapiens <400> 135 ctagagcgaa ctgaaccaga tatctgctaa ggctctgata gagaacagct ggaagctcag 60 aaaggtaaac ataattcaaa tattggtgaa tatgccagtg cagccgagaa ggtgacagga 120 tttgaaaaat gtgccaggac acaatgagaa aggccttgga ataaatacaa aaagcccaaa 180 ctttattctg taaaagtggg gagctactga aggttttaat caaagcaggg ataatctcat 240 ttccaaggca aaaaaacaaa aagaggcatt ccttcctaat accacatgta ggagctgtty 300 ttattctatg gtggattatt actttagtag tatcttataa agacagtgcc tgaaggtctt 360 ttatctgtac attgatgtaa cacttttcaa aagcatatca gcagacacat ttttggaagc 420 atgcattctg aaacttgaac ttcaaatagg agttatggct gatatcatgg agtaaggtaa 480 aacagaagct gactcctctc cagtattcaa ggctgactgt tgtctctgga actgagaata 540 ctgggaaaag tgtgagttgg acactgtgca caactctaat taacactgtt ctaaaggga 599 <210>136 <211 >599 <212> DNA <213> Homo sapiens <400> 136 tgggcatgac cattctctag tttctatctg tggcttggaa tttgtgttaa tgtattggtt 60 gggtcctttc aattggaatg gggagagaga ggaatccata aatctgtgac tcagtgacct 120 ttaggaattg gaagccaagg tctatttctt atgtcttatt ttgttattgt gcatagcagt 180 gtctctcaac tgtttgaatc caggcccctg gagatgaatg tggactgtca gtggtgtggc 240 tttttccacc tgcaccttct gcagagcagg gtgcaccttg agcaccttga gcacgggcay 300 cttctgcctg tgcacctgtg cacatgaagg agcctcttgg ggtcttgctg cctttggggc 360 ttttgctttc gcctccagct ccttatactt ctgcccatat atctcactct ctgttttcca 420 gcctgtcttt tctgttttct gaagtctgcc ctttcccctt catggttagg tgaaggaagg 480 ggaaatagaa ggaaatattt gaagaggaaa ggttgtggca ctgcagggta tttgtgactt 540 tgtccccaat tgcattcttc aagtgcagtt cttggttttt agggtatctc tttgagtga 599 <210>137 <211 >599 <212> DNA <213> Homo sapiens <400>137 ggaagatgtc tgtgctgctg gtggcagcag ctgctctatg catgggatct ggagggctct 60 gtggggaccc acatgtgtcc actttcctgc ccactctgcc ccactcccct tccctcactc 120 tgcccgcctg ggcctatact tccccttccc acagcaacct agcagaagct ttgcttctcc 180 atgtgttttc tgagaaatcc aggctatgaa aagatatagg gaaactttat aagattttct 240 cagaataagg acaaaagact taaagataat ctcactcaaa gagataccct aaaaaccaak 300 aactgcactt gaagaatgca attggggaca aagtcacaaa taccctgcag tgccacaacc 360 tttcctcttc aaatatttcc ttctatttcc ccttccttca cctaaccatg aaggggaaag 420 ggcagacttc agaaaacaga aaagacaggc tggaaaacag agagtgagat atatgggcag 480 aagtataagg agctggaggc gaaagcaaaa gccccaaagg cagcaagacc ccaagaggct 540 ccttcatgtg cacaggtgca caggcagaag gtgcccgtgc tcaaggtgct caaggtgca 599 <210>138 <211 >599 <212> DNA <213> Homo sapiens <400>138 tccgagacat tatactaatg tatgatggtc tccactcatg tttttggagg cctcatggga 60 gtagtgttta taggcgtcac cttaggaaat gctgccctag acttttctga ctgtttgcca 120 gccccatcag gctttggatc tcgtatcttc agaaatgctg tcagtatttt ccaaggtaaa 180 aactagtaaa gaaaaccaaa caaaaatcca gaaatgtgct cagttaatag ttctcctagt 240 atcttcccag aatagcatgt gcatttcacc cttgtcctgg agataatgtc tattacctgk 300 attataatct ggaaatgaat tctaactcct tttattatgg gcatgacctt gtttctgtac 360 tcccagcctc caaccagcaa gaaaatgggg gtctcagtcc cacagccaca aggactggga 420 ttctgtaaat gccccagatg agctgggagg cagattcctc cccagagcct gcagatggag 480 ttcagcctgc ccctgacacc ttgcgtggga gacactaaca gggagaagag ctgagcctcc 540 cccagccttc tgacctacag caccatgtga tcatgaatat gtgttattct aagccacta 599 <210>139 <211 >599 <212> DNA <213> Homo sapiens <400>139 cactgcattg atttaatgca attccatcca aaaggatgag acccacacag aatcccaccc 60 aaggccaacc acgttagact tcactataca gactctgccc catccctgct ggagccagtg 120 ctgaccaggt tcaacacagt ctccaaggct gtcagcccaa ccagcaggtc ctgctgcctg 180 gatgggtttt gttgctctca gccctgcagc cataaacctg gcactaccag ggtttccctt 240 ccactaagag agaagagtgc taagccgggg catgagttaa gagctgaaat tgcagcctcr 300 ctctgaccat ctgggtgtag tatcatcaac actgggagta caaatggtca agaagggacc 360 aatctctgac ctgctctacc agtgggctag gaggagagac gtgtcacaga gtcaagtgga 420 catgccacgc tgcacatcag ggcacagtga cagttgcctg acacccctta cttgctccag 480 tggcagtggc aggactgaat tttggagaat taccctcccc actgtgaaca agaacagaac 540 cctgtcagtt aaggtgcttg gccatccttt gccgtggcct cccacatggc cacgttgga 599 <210>140 <211 >599 <212> DNA <213> Homo sapiens <400> 140 aagaacaaga aataacttaa taggccattt gtcaatgaga gtacagtgta ggaagggtgg 60 aaagtgaata taaaatctag attggggctt ctggtttcct gttcagccta taaggagctt 120 agaatttgcc actcagtctt gacaacaagt aaaatgctga acaaactgaa aaatcaataa 180 ttcttctcag atccataaga gaagtgagat tacagggcaa actactacct tcagcatcac 240 cccgcacccc caaccccact aaatagaaag acaggagaat acagagaatc ataacacagr 300 cgcagaaacc tccttgagag agccagggta gataaacatg aactgtaatt gatgaattcc 360 tggaggatca ctgtggatga cctgaaggat taaaaactct agagggactc actcaaagga 420 gggcccaagc ttttgtgatt tttttttttt tttttttttt ttttgccacc tgaagctcta 480 caaggttcca aaggtgaata ttaaggaaaa tccctcatgc tctggcagcc agaggggaaa 540 aggaacaatt ttgaaatatg ccagaatatc gttcttaaca atgtctgccc tcaggagaa 599 <210> 141 <211 >599 <212> DNA <213> Homo sapiens <400> 141 aaaggcattg gagaggaata agcaattgag aatatgtttc ttattctcaa ttgatctaac 60 agataatagt ttattcaaaa taatagcaac aatgtgtttg gttgtgtatg tttatatata 120 taagcataca taagcatata tagagtattt tttgttataa ggtactcata ctactcatga 180 agtgatacag tgttatttga aagtggattt gaattagtta taaatgtata ttgtaaactc 240 taaagcaact actaaaaaaa gatttttttt aaaaaagcat gactgatatg ctaaaatgar 300 gaaaatgtgg aatcctataa actgctgttc aatgaaacca caaaagccag gaaaaagtgt 360 ggaatacaaa cataagaata aaaaataagg gaaacaaata gaagatgata acaaatacgg 420 tagacattaa tccaaccatg ccaatactca ctttaaatgt aagatggtct aaatgagcca 480 actaaaagac agagattttc acagtggatc aacaaacaag acccaaccat atatgttgtc 540 tacaagaaat ccactttcaa tatacagaca catatacact aatagtaaat ggatggaga 599 <210>142 <211 >599 <212> DNA <213> Homo sapiens <400> 142 accagacaat aatttgacac cactatgctg aaccaattca caccagtctc tcagaatgtt 60 gtgcatgtta ccttgttcct tttcctaaac tatttaataa cacatatgcc aatggtgaaa 120 ataaaataca aaatttaaga acaactgaca ttggctgtga actttgtagt ttataaaaca 180 ctttcacatt aacatctcat ttgatcctct ctacaacctc cctctagaaa aaggtgggaa 240 taaacaaaaa caagcaagca aaaccttcgt tttgaagacc ttaggaatta gcccaaggty 300 ttatgactgg tagatggttg aggtgagatt caaggcaagg ccttctggcc ataacacacc 360 attccttctt ctttctgcct ctctgtcctt atgacttgac acataaaaaa tgctagaaag 420 tgtcacatct gtaccaccgg ggagactctg tgtgaaacaa tagtttcaag gagggtcatc 480 ttttcagaaa ctgcaatcac aaaggatgca ttctgtactt taaattttgt aattccagcc 540 taggcaacat agggacaccc tgtctctaca aaacatcttt aaaataaaat gatataatg 599 <210> 143 <211 >599 <212> DNA <213> Homo sapiens <400> 143 gtagtttata aaacactttc acattaacat ctcatttgat cctctctaca acctccctct 60 agaaaaaggt gggaataaac aaaaacaagc aagcaaaacc ttcgttttga agaccttagg 120 aattagccca aggtcttatg actggtagat ggttgaggtg agattcaagg caaggccttc 180 tggccataac acaccattcc ttcttctttc tgcctctctg tccttatgac ttgacacata 240 aaaaatgcta gaaagtgtca catctgtacc accggggaga ctctgtgtga aacaatagtk 300 tcaaggaggg tcatcttttc agaaactgca atcacaaagg atgcattctg tactttaaat 360 tttgtaattc cagcctaggc aacataggga caccctgtct ctacaaaaca tctttaaaat 420 aaaatgatat aatgtaatac agtataatat ggtatgatat aatattttat gttatatttt 480 cccattgtgt tgaagaaaat gtttaaggtg agctcttttc ctgtctttct caaaaaggta 540 tggcaggatc gtcatttact tgctatcctg ccttggtgtt ggcgtcactg gggttgtgg 599 <210> 144 <211 >599 <212> DNA <213> Homo sapiens <400> 144 agcctgagca aaaagagtga aactctgtct aaaaaagaac tgggttttgt tggttctatt 60 gtcccctccc cagcccttga agcttggtca tgtatatttg gatttctgcc ttcttcctct 120 ctcttatatt aagtggcaag cagtaggctc ttttccaaag gtttcaactg aacagatgtc 180 actggtgcaa tggtgcaagt acattaatga tgtaccttga ggtttacaga tcataaaatg 240 tgtggtaaag ataaagcatg atctttttaa accactatga ttagtccatc cttgtcacty 300 tttgagtgaa cacatttgag ctgtgtgttc cttttaggga aaaataatat acccctgttt 360 cccagcttgc actcatccat tgtctatagt cctcatagcc aggtcaaaga tctgatcatt 420 tgtattcaat tttaatcatc cagtgaataa tctctgctct tttgcacaca tagtccagag 480 gtaagtccaa ggttttgatc ttgatttaaa ggtctaaata tagaaatata tttaggaata 540 tagaatatag aagaaacaaa tatagaaggg aatatagaaa aataggatca tagaaaata 599 <210>145 <211 >599 <212> DNA <213> Homo sapiens <400> 145 ccgaagcagc tgctgttaca catcccatga gtgtacagtt tagcactgct cccacagacc 60 cactgaccca gctttattca tgagcaccgt agagatcatg acaacaggta agtagttcaa 120 tgttccacat ggctgtgctt atgagagatc atgaactatg ggatccagtg gcttccaagt 180 cattttaatt ttaatatgga aatttccaaa catactcaaa aatacaaaaa tagttgaatg 240 aatctctatg catatccctc agctccaaca gttaccaact cctgatcaat cttagtttty 300 ctatactctg cctagtttcc ctatccactg agtaggaatc aatccagcca tcatagcatt 360 tcatcttgta atattttcct ctaaagtagg aacacatagg tatctctgga actatgtgtg 420 cactatcttc aggacactgc tgaaggagga gcaagaacta ttcctgtggt tcttaaaatt 480 caatacaagt aatcacacct ttgatccacc tgtggggact gatccctctt gtgggagcaa 540 agatggggcc atggtatata aaatataaat ataaaactaa tatcaatgtc attgtccta 599 <210> 146 <211 >599 <212> DNA <213> Homo sapiens <400> 146 caggaagtat ttccatccct tggaaatgag ggaaaatgtg aatctctcca aacagtaatt 60 taatctacca caatcagata cccctgcatc accaaagaat gtgttgaacc ctactctggc 120 agttgaacta gtaatatgac caattgcatt agctagattt ggctgcaaga acagataccc 180 ccaaatctct gtagtacatg cagacacatt gagcagtagt ttactgggga aacagctttt 240 tcttggccat gtcccataca gcagctgtag gtcagctgct gcagctctgc tccaggctgy 300 agctctcctt ctgagaccca ccctgaagga acagcactga tttgggatct gctgttcttg 360 tggcagacag aaggagcaag agggctgtca ggaattcatg atgcctctca aagcttctgc 420 cctgaattga tattctgcca cttctgctcc ttgggcgcaa tcaagtcagg tggccaagcc 480 tgacactggg tggggaagta tattgcctac agagagatac tgctgtcaat catctggcaa 540 tgggtgggaa tgggatgtaa aatcctctta cagagaggaa gtgaatagct gagaggatt 599 <210> 147 <211 >599 <212> DNA <213> Homo sapiens <400>147 ctctgatggt aaagtgtcaa cttgattgga ttgaaggatg cctagatagc tgggaaagta 60 ttgtttctgg gcgtgtctag gagggtgttg ccagaggaga ttcacatttg agtcagtgga 120 ctgggagagg aagcctcccc tcaatgtggg tgagcaccat ccagttggct gccagtgtgg 180 cttgaacaaa gcaggcagaa aaaggtggga taggatgtct tgctgagtct tctagctttc 240 atcattctcc tgggctggat gcttcctgcc cctggacatc agactccagg ttcttcttgy 300 acttacatga gtggtttgcc aggggctctc gggcctttgg ccacatactg aaggctgcac 360 tgttggtttc cctacttttg aggcttttgg actcagactg agccactcct ggcttcctac 420 ctcctcagct tgcagacaac ctatcgtggg acttcacctt gtggccgtgt gagccaattc 4B0 tcctaataaa ctccctttca tagatatgta gatcctatca gttttgtccc tctagagaac 540 cttgaccaat ataatagctg actgtgtcaa cactgagtga gcagccactg tcactgtac 599 <210> 148 <211 >599
<212> DNA <213> Homo sapiens <400> 148 tgtattgttt atagtgaatc tactgctttt aaaattaaac attagatgtt atatcaataa 60 tgttcacaca taaacatgct tgaggcagtt cccatggtgg tatgtttatg tgacatcagg 120 aacggaattt gagctttcca attccaaagg gattccttta ggcccatcat caatataaat 180 gataccattg tttgaaatat ttgcaaaata gaaaaaatta aaacctcatt agaaagtgtc 240 ttactgattt tttttattac cttagttgtc agggagactt ctagacctta atagctacck 300 tcttttctat aatttaatga gcagtcacac aaacaccaat attgctacag aaagggactt 360 tccagctttg ggaatatctg tttctgacat ttcctttcaa agggggattt ttataaacat 420 aatttttctt cttccaaaag aggaaccaca ctatgattcc aacttccatg gagcccatcg 480 gggatggtgg tatttcagtt caattagggt gctgtctttg ttaactgttg tgtttagttg 540 tgatctcaga cttcagattt gaaatctctc ttcggggaat tcatttcaaa agatccaga 599 <210> 149 <211 >599
<212> DNA <213> Homo sapiens <400> 149 cagggccagc ccacggaaaa cacaaagccc ttttttccct agctagcctc tccatgtgga 60 ggaacaagtc ctattgcttg gtggagagcc aaagcccttt cctttctcac ttactcttct 120 ctcactgcta ctgggatcct ggcaaaccac acaggcaggt ccatgtggct tatgacacag 180 gagttccgag ctttgcgaca tgacattggc aactgctcag ttatccgtga ttagttatga 240 atctaaatgc gtgggcttcc cccttttcct tctcaaaggc tgagcttccc cttgccctty 300 aggagcaaaa gtcttcccct ttctactcca gcactccttg gtaggcagag aagcatttac 360 ttcttccctg cctaccctga gccccggcag tattacaaac aaaagtaaaa agtaaaacac 420 aaggcaaaac tcatcagcca cacgggcttg ttttattcca ttaatattgg ttgttctctt 480 ttctgggagt tgtgtaggca tctaatttga ttattttagt tatgtgtccc tctctaatag 540 aaaagaggag tgagtttgcc tgtccttttt ccgtttcaag cgtctgctgg ggaagggcc 599 <210>150 <211 >599 <212> DNA <213> Homo sapiens <400>150 gctcactccc attgtttact tccacctggg gctctgggtg cagaaacgtg agtcctccca 60 ggtttaggag ggagaaatac atttgccagc agggtttacc atgggcaggg ggaaggggat 120 ggtgttagta gctgcttgtc tagccttgtg atttcgtctg gttattctca ataggagact 180 tcttcatcag ttgccgtatt tcacaaggaa agatgacacc aataagaaag aaaacgtatt 240 tgctcttgag tataatactg tgatttattc agtgaatgca tcatcactag ttccctaaar 300 gctctgctct ctagaaactt ttcatctcta agaagtctgt gtgaataaaa tgttatttga 360 ggtctttggg ctcaccgatt gggggaacca gaaaccacct tcaaaagtta aagtacccat 420 tggtcttaca gacaagcatc aggaaccaga gggcctggtg gggctgggag gaagctcggc 480 agtgacagct gaggtgctca tgtccttcca tcccactgcc cagtggataa tgagctcatt 540 agtcagacga ggaccagccc agaatagcca ggagtaagca tgtcacatta cagagctgt 599 <210>151 <211 >599 <212> DNA <213> Homo sapiens <400> 151 ttcttctcct ctctccactc tgttgacagg atagcttcat cttaagactt gttgtctcat 60 cagtgtaaga tgactgctaa gttgtatgtg agcccacaat ttcctcattc attccttgaa 120 ggaagaaaaa agatttcttc aggaacttct gacttaaaag caatgaagga ctttcccaga 180 agtccatttc tcattggccc gaattgggtt gtatgcccat ttctcattgg ttcaaattgg 240 gtcacgtgcc cagtcactga catggaggat acgatttccc taaactaatc aggcctcccr 300 ctacaactag aaggagactc agctcccaca:aacatatgaa ttgafcggtgc gggagagtgt 360 agtgggaatt ctgttaggaa agagaaggaa gtcaacaatc gggtacgctg tgtctaattt 420 aagtccatga ctttaaaagt gagctttttt ttttgttaca aaaataatgt aggcttaatt 480 tttttttttt ttttgagacg gagtctcccc gacacccagg ctggagtgca atggcacgat 540 ctcggctcac tgcaactccg cctcccaggt tcaaacgatt ctcctgcctc agcctcccg 599 <210>152 <211 >599 <212> DNA <213> Homo sapiens <400> 152 tgtgtgactt tccttggagc aaagataggc ataagatatc aagctttggt tgatctattg 60 aatttactgt ttagaatctg tgattgacaa ggtactatca gtgtgtgtat gctctaagtc 120 aaattcctgt gattactggt agagagactt tagctcaaag ctttggggaa aatgtgccta 180 gattttcatt caatctgggc caaatctgga gttgtacaaa tagatagcat cggtcttgtc 240 cttagtagcc agcatttttg tttaatagga ggagagaaac ccaggacgac actgaggaay 300 agatatgacc agggcacttg acttcttgtt tcagcactca gtcattacac aaacagttgt 360 tgaacaccag gcactttgct tggtgtgaca atgcactccc gccttccaag agctccagac 420 ccacagggga gtgctgttgt acaggtgcta ggatagaggt ccggggagta gaggcagaat 480 ttgggagcca tcagttctat ctgaggctag gaaaggcttc ccaggggagg taaaatcagg 540 actgaggagg tcaaagagcc ctccatgcag aggtaagaga ctgacaagca caggaaact 599 <210> 153 <211 >599 <212> DNA <213> Homo sapiens <400> 153 ctagattggg cacaatatct atttcattca taaatgatcc tagcaattga gaaaagagaa 60 tcatctacag aaccaatctc ttacttcgaa gtttttatgc tgattaagca gaaaatggag 120 tgacatcacg aaagactgtg attccattgc acatttccta agaacaagtg gctccctata 180 cttgattgtg gatttaggtg ttttcaagtc ctttggctgc caaacagatg tggggtaaga 240 ttaccttctg gtaagaacgc agtgacaagg catgccaccc ctgccactat attgcttgcy 300 gcaaagggga ggcgtcgtcc aaggcgctca atggttagta agatcaagag agctcctggc 360 agttccacca cgcccgagat gaaaaagtct atatagaggt tgccccctat aattcccagg 420 cgcatgacaa gtccttgata caccactgcg cttgtgaacc tgtagcaaca ttgaaagaca 480 ccagagaaca agtaagagat aacttcaagc tgatttgaag gaagggatgt attgtaaatt 540 taacgcaagc ttttaaatcc atcacaagtc aaacttacca agcaaacata agaataagt 599 <210>154 <211 >599 <212> DNA <213> Homo sapiens <400> 154 ttcccaatgt agccactgtg gtcctcaacc atgctattcc tgcaaacaca gaaagtttga 60 aagggaggag ttaggggtct gatttcatta acattttaca gaacaacaaa aagtatttgc 120 ttagtggcct ccagtctgaa gtctttgcca attttaagca caaatgatag aactttctaa 180 taatgtaacc aaatttcaac aacaatgaaa ctagatgata gctaatattt tagagcgcta 240 gatgcctttc tgagcaggtt ggattatagg aagtacaatt caagaaccgt ttgttgagcr 300 tgagcagcca ctacattgga acattgttcc aggcaatgac ctcctagaga gccaaagcac 360 actggctttt tgtccaggtg gtagtttcca gtcatgcctt tgagccacca cgttcccaca 420 gctggtgccc agctgtcctt tctgtgcata ccttgcggtg gtgacacaag gaatagccgt 480 tcccagcaca cctggggagt tcctcacgtg agctgacctt ggtttctaga gtggagcaag 540 ctttgaggac caggatcttt ggaaggggac atctattctg tgtgttacca ctaaggcaa 599 <210>155 <211 >599 <212> DNA <213> Homo sapiens <400>155 ttgcactcca gcctgggcaa cagggtaaga acctatctct aaaataaata aataataaaa 60 aataacaaaa ataagcctaa tgtctaattg tatttctggt gttctctctc tatggatatc 120 atatcttcat tggcccgatg ctaaaaatcc atgtggaggg agcaggtgac acaggatccc 180 gggcacacat tccatcacct cctccaggtc cctcgagtgc acctctcctc ctacctccag 240 cttccatagg acttgtgaag gaacagaatc atagtctagg agggaccttg gggaattcas 300 tgtcccactt ctccagggct gctccaacgg tcctgcctgg gtttcacaca cttcccctgt 360 gccctcttct gcagtaaagg atacgggttg gcccctttct cacgcaaccg tttctctatc 420 tccacttcct tacttctggt agagaatgtt tttcatttat ggttcagcag ttgaaatttg 460 aatgaaaata ctgagcccat gaggacagac cttctgcttc atgcaaaagt cctttgacag 540 tgtgagggac aaagagtcgg cttctaccac ttgacaccag tgacctcaat acaggatca 599 <210> 156 <211 >599
<212> DNA <213> Homo sapiens <400> 156 ggaggaatcg gagggagagg ggcaggtaag tgagagtgtc agtgagcggg cgcagagggg 60 actcccctcc agcacttctg tttccctgtg atgcaggaga ggaggccttg ggtgttggac 120 cctaagaagg aactcagtca atcactgtga gatgtgtgag tgaacacatg gctgccaggt 180 atacaggggc cgtggtgcta ctcagggttt gaggaaggga gagaaccttt gaagctgtgg 240 taagggagag ctggggcatt gatctgggat gcagaggttg ctgtggttga gagctactcy 300 agtgagcaac atgatggctt cagagtgagc aggccccatg ggagagggcc cagctgtgtc 360 ttcctggagc ggtaacacct ttcccctatt ccataggtat cctggcatcc atctgtggtg 420 gccttgtgat gcttttgcct gaaaccaagg gtattgcctt gccagagaca gtggatgatg 480 tagaaaaact tggcaggtac tgtacaaaat tcaatgcacc ctaaataaaa gcaatattta 540 aaaccacggg ggaaagaatg acattgagaa aattgaatat ccacagggaa aaaaataag 599 <210> 157 <211 >599 <212> DNA <213> Homo sapiens <400> 157 gagaggggca ggtaagtgag agtgtcagtg agcgggcgca gaggggactc ccctccagca 60 cttctgtttc cctgtgatgc aggagaggag gccttgggtg ttggacccta agaaggaact 120 cagtcaatca ctgtgagatg tgtgagtgaa cacatggctg ccaggtatac aggggccgtg 180 gtgctactca gggtttgagg aagggagaga acctttgaag ctgtggtaag ggagagctgg 240 ggcattgatc tgggatgcag aggttgctgt ggttgagagc tactccagtg agcaacatgr 300 tggcttcaga gtgagcaggc cccatgggag agggcccagc tgtgtcttcc tggagcggta 360 acacctttcc cctattccat aggtatcctg gcatccatct gtggtggcct tgtgatgctt 420 ttgcctgaaa ccaagggtat tgccttgcca gagacagtgg afcgatgtaga aaaacttggc 480 aggtactgta caaaattcaa tgcaccctaa ataaaagcaa tatttaaaac cacgggggaa 540 agaatgacat tgagaaaatt gaatatccac agggaaaaaa ataagaataa atcctcatc 599 <210>158 <211 >599 <212> DNA <213> Homo sapiens <400> 158 tcccacattc ttgatggagc tgtcatgaga atcaggttgg gggcttctct tgtctctctt 60 tagcctaatg ggtcagagac cacagggaac acaagaaaaa aacccaggaa gggctgtgca 120 cctgacagct tctttgttaa actggctaca tattatgtgt tcccagaaac ttcaacagca 180 ttacaaatcc taactcatcc aacattatat aaaaatactc tggatagatt gaggtcttta 240 tacagtatta caacagcgcg gcatgatgta gctgaaatgc acacgtgcat ctctgcaagr 300 cacagctttg caaggaggat cagctcctgg atagctcctt ctttctgtct ttgtcggggg 360 cctcaaaggt gagagcggga aactggggtt ttcttattcc tgccacattt acaggaatgt 420 ggactgaaaa aacaaaggag aaagtcttta ggaaagatta tgtaactagt tagaagaggg 480 tgttctgtta ttatttaata gtatagctgg ttttgatcaa atacattcat gaaaacccaa 540 ctctaaggta acaacaatat ctgtctccag gatcattttt tgtctgtgtt cagacctta 599 <210>159 <211 >599 <212> DNA <213> Homo sapiens <400>159 tttcttgtgt tccctgtggt ctctgaccca ttaggctaaa gagagacaag agaagccccc 60 aacctgattc tcatgacagc tccatcaaga atgtgggatg tgccgaccaa ggatttgaga 120 aagttgtaca gaaatgtgtt catcaaatct ggtcaaggga ctaagctcct agctgaccat 180 tcattctgaa gattgcatgg aggatgaaca tctgggaatc ctgttaatga gaaggctgaa 240 tcacaggcac ctgggccaaa gggtgtgagc attcatgttc tctgctcacc ttggtttccr 300 cacaccttcg caatgtgaac aggtcaggag tccctcccgt ccacctcctc tgtaacagct 360 ggggttccag gcatggttta ggccctgttc cagcaataag aaccaatctg ctgtacaatc 420 tgaggacttg gctctgttat ttacaaaatg atgctgtggt tctgagatta tttgggacat 480 ttttggctct cctttagtgg acacctagag ccacagattc ccttctttac taaacaaatc 540 ccatggattc tgatttctgg gtcttaggat tttaaaagtg aagggatatt tttcttata 599 <210> 160 <211 >599 <212> DNA <213> Homo sapiens <400> 160 ccacccacat tcctggccct ggcaagtcag tcttacaaca aggtaagaac aggcccagaa 60 accaactata ttgtccttcc acacaagccc cacaaaatcc ttctacattt acacagaacc 120 cacacagctg aggcatcagt acctgcctct atgttttctg aaggaggaaa aaatatagaa 180 aaataaaaat aattatatta ttttaggttc tctactttga aaatggccaa aattggaatc 240 tttttcttga tctaagtagc tacatcaaaa tctgtaggcg cagtgatttg caccaagtty 300 cgatattgct ggaaaatatt gaagatgctc tgagggtttc tatggatatc cattgtctca 360 ctgtcagatg aaaagagagg gaagttttta gaaatgtgac actttgcagt gagggaggac 420 aagagcaaac ttacctacag tctgtcacag gcacgatttt ttttttacac ttttgtgaat 480 cattgaattc aatgccgagg ctactcatcc attcacaaac acaggaaaaa attataggtc 540 atgatcccca taaatgaaga gtaatcagtc caatcccaca gaacctggac cttttgggt 599 <210> 161 <211 >599 <212> DNA <213> Homo sapiens <400> 161 tttaatagct agttcatttc cactaagaca ttcagtataa ataataagta aaaataaata 60 gaaacattca gttttatttt aaatagtagg agcaggtacc ataatttctg tagttactct 120 tttagtacaa tgatgcatgt atactgtgtg taaggcatat tagcagaaat tgagttcagc 180 actagggaag atgatttcat tccatgcaat gtttctttaa aaaaaaaaaa gacttatata 240 gatagattct cagaacagcc catggcaaat ggacagttat ttggaaaact caggttccar 300 attcactgga gtgtagaatc tctggttggt tggggaggaa attcctcttg cagttgttat 360 taataattat gtgaatatta ttaactatat taatgtttat aattttgaag accttgaagg 420 actggagaca gagaagcatt tttgaacacc ctctgtagcc tatgcactgt tgtaggcatt 480 gatgggtggt accaaagatg ggacactgtt cctacctcca gagatcttgc aggctggctg 540 cagagagaag gcagagagga ggtaaaagaa aaataaaggc acatgtgtgt aagtcaccc 599 <210> 162 <211 >599 <212> DNA <213> Homo sapiens <400> 162 tatttctgaa aaaacaaaaa gccacttgga cttgtcccct attttacttt ctgctgacca 60 atcaacttgt ctgtcctagt tacagaaagc tgtcctggac ttttcatttg tataatttgg 120 ttgcttgtgg ttgggtctgc catgtggaag aaccttgagc tgggggaagc agcttggcct 180 ccaagtccac tgaagaccac cattccaaga tttcctgggg aggcggtaca gggcagtgat 240 gaagattatg ggagccacac tgcccagctt cgcatttggg acactcctgg ggagagcaar 300 agggaagaat gagaggttag ggtgatagta aagattctac ttggccaata ttattgtatt 360 gtggcattgt ggtctctgga tttagtgtga gttgatagct gaccttttcc ttgagtgggt 420 gtttttgttt gttctgcaga agcatcttgg tggctcctct acctgaaagt ccctcgatgg 480 ggtcagttcc agttctccac ttctggcccc gtctggtaca tgccactgcc tctcactgcc 540 tgggctctct atccttgaca ggctgccttg aagttgagcc cacactgact ttcttgcct 599 <210> 163 <211 >599
<212> DNA <213> Homo sapiens <400> 163 acacatgtga cccagtctca agcccagact cccagctaca ggaggctggt tctccaagca 60 actggatatg ttagcaagtg tggtattcga aggagatttt tttatctatt ttcaactgag 120 gtacactttc atgtatagtc aaatgcacag atcttagatg tagtttgatg aattttgatg 180 aacatgtaca cttgtgtaac tcgcaagtta cgatcgtgac acagaacatt tacatcaccc 240 cagaaacaac ttttgtttta cggcaaaatc aatctctgct aatttcttcc catggccagw 300 ggcaaatgat actggtttcc ttcaagagaa attatttttg cctttctgga accttatatc 360 aatggactca tatataatgt tcatttgtgt tatctgacat ctttccttaa tgtaatattt 420 ttgagcttca tccatgctat ttgagagtat cattaatgtg ctccctttta ttgctgaata 480 gtatgccatt gtatgaatag atcgcaaatt atttattcat tttcttattg attgacactg 540 tagttgccta cagtttgggg tataaaaaat aaagctgcta tgaatattct tgtagatct 599 <210>164 <211 >599 <212> DNA <213> Homo sapiens <400> 164 aagaattaaa agatctaaat aaagatacac catgcttata gattgaaagg ctcaatatca 60 cttctcatca aattgatctt tggattaaac tctcacccaa acactattgc tgcagtcctt 120 ttttggaaaa aatgtggagg acttacatac cttaatataa agacttataa aggtacaaga 180 atcaagacgt ggtattggcc aggacccttg gctcatgctt gtaaccccaa cactttggga 240 ggctgaggca ggaggatggc ttgagcccag gtgttcaaga ccagcctcag caacagagcr 300 agaccctctc tccacaaaaa aaaatgaacc attagatggg tgtgatgagt cacacctgta 360 gttccagcca ctcaggacac tgaggggaga ggatcacttg acccaggagg tctaggcatg 420 agtgaacctt gatcatgcca ctacattata gcctggatga cagaatgata ccctatctca 480 aaaaataaaa agatatgcgt tattggcaaa aaagtatgca aaactaaaaa gggatggtcc 540 agcaccagac ccacatacat atggtcaatt gattttctat atagatgaca aagcaatta 599 <210>165 <211 >599 <212> DNA <213> Homo sapiens <400>165 actctttgtg ctcaaaatgt agcaaaaagg ctctatgtta ttatcatgga aaaccatcat 60 gcaaatagtg ttactgtctg tcgataccgt atcaggtggg tcagaaaggt ttgtttctgc 120 aagacttatt aaagcttccg tgcaaaacta gcttccaggc agaatgcagt atctctagga 180 tgggtcccag tacatgacct cctctcctgc tctcagtcca tcttctactg gccgcagcca 240 ctccgggact gagggaatgg gggatgagtt gaaggaacag tgggtcccaa ggcataaacr 300 gagatggatg aatagactat gagatctgaa gaggttaggc agctatggag aagttagtag 360 ttggtcattt gtggtcatga ccattttttt catgtctttg gtagccactt atggcagaga 420 gacttgccat tggatggtgg gaccccagct tctgtgcatc tatctaaccc cctcgcttac 480 ttttcagtct ctgtctctct cctgagtctc atctgtcttt ttgcctttgt tcgtctcttc 540 ttggaaacct ggacctattc agaccactgg tgctcaggac ccagtgtgtt tctgctgat 599 <210>166 <211 >599 <212> DNA <213> Homo sapiens <400> 166 aggaaacaca caaagtttcc atgtctgtcc ccacctctga cctcaacagc ctatcgccac 60 ctaaagcctg cactgccaaa tccatcacac tttgtactct catgccccat tgtctccatg 120 aacattcagt agagatccct agagatgagc ttgcacgtga gagcagtttc ccatgaaaag 180 gactctgaac tgttgttttt ctctaagctt ttatatgaaa tatttagaag aacttactac 240 atttccagaa tggtaggaat ctgttgcttt tgtgtttgtt tgttttctca tgtccatctr 300 cttacaaata aaaaaaagag aatgattgta attcttgaag actcatttct ggtttgtggc 360 attgatagct tcatctgttt ccctgtccta ggaaatactc accttgaatt tttctgtttt 420 aattcagcac tgattgatcc.aaggccttca atgtaggagt gctaccatgg aaatggacag 480 agttatcgag gcacatactt caccaccgtc acaggaagca cttgccaagc ttggtcatct 540 atgacaccac accagcacag taggacctca gaaaagtace caaatgcgta cgtctttgt 599 <210>167 <211 >599 <212> DNA <213> Homo sapiens <400> 167 ttttgtagct atttagagca gagagactgg ccatgagttg gtcagacccg gcttctgtcc 60 atgtacccac cccttttatt tttcagcatc tgtctctttg ctgtctctca tcagccttcc 120 tgcctttgcc cttttctttc tggcacctca tatcttttca gaccattgat gcttgggatc 180 gagtgtgttt ctacccattg gaatagatgt agaaatagaa agagattcga ctctccatag 240 atatgcacat actccttcct cgtgagccaa gacagaaaag gccaacacaa cttttactty 300 gggaatcaga ggttagaatg atagaattcc aaggtggaaa ggctgcattg actcttactg 360 tgtgttgtag aaaacactct aagtgtttgg tcatttgtgg tcctgacagt tttcgtaatg 420 tgatcacctc gccttcagat agcctcctga tgcataaagc tatgaggaag gagagccaga 480 ttaacatttc ttatctctga gaccctttgc ttcaaggcaa tattcctgag acattttgct 540 atgccctcta catctgacac aatttgattc ctgagcactt agctagaagc acgtctctt 599 <210>168 <211 >599 <212> DNA <213> Homo sapiens <400> 168 atgcttcact ctgtctcccg tccaattaat tatttctcat cattccctca atccaagtaa 60 caaaccttga aacacgagca tagacaccag gcttattggg gcgtgcacag ccaagacccc 120 aagaagtgac tccttgtaaa atgtatttgt ccttctcgaa gcaaaccaga ggccctccac 180 tgtcacccta aacagaggta ggggaaaatt catgtgagct ttaagctgcc aaccttttaa 240 tatgggatgc catccttctc ttatccatat gtacattttc ccagtaattc aaatcagaar 300 ggaacttatg agcatattac tcaagcatct gcagtgctta agtacttagc aaagtctatt 360 caacaaaacc acatcactta gttttttcct gggaaaaaaa ataatccctt gtgaatcctg 420 catgcattgc ttcctaactt ggtgtttcct ttagactggg ctagcctgga catcattgtt 480 aagtgtgtgt aatttgtctc ggtcctgtac cctctacctt cctctctact ggaaaagcca 540 ccacttcagt cactggtgac cagcacacac caggaaggtg agtggcctga ggtagttat 599 <210>169 <211 >599 <212> DNA <213> Homo sapiens <400>169 tcctggaaat atggtgacgg ttgcacacca ttgtgaatgt actgaatgcc actcagtggt 60 acctgcaaaa atggttaaaa tagtaactct atgttgtata aattttattg caataaaaaa 120 gaatagtcat catttactaa gaatcaacct ttccaggcac aagctcataa tgtggtatat 180 ctcacttaat cctcacaacg gtcctatgaa acaggcactt gtcattcctg ttcttcagtt 240 gaggaaactg aggcgtaagg aggttgtata gctcagcttg agtctgggtc tgcggagtcr 300 ctgcccaaat gcttcctccc catgcgtgtt ggccccactc ttgcttccaa ccttccacat 360 gtttgttcat aaatttcatt cttattcctt attactttct gaagtctcag ttcccataat 420 tatatagaca tatttctatc tcacagtaac attgccaaat tattctctaa aagggtgtga 480 cagtggaaaa tgtcactgga aaacaattac tttgcctcac ccttgtgata ttcaattttt 540 aaaatattag ctaacatagt aggtggaaat tgtcctgatt cattttctaa tttacactt 599 <210> 170 <211 >599 <212> DNA <213> Homo sapiens <400> 170 aacactgtgt ccaggaagga agacaggtta atgatgaagt tgatctcctt tgattccctt 60 tctcagttct ctcaagccta ccatatctgt tgtccaacct gtgaaaactg ttttctcatg 120 tatttgatag tccttcatgg cagaaaggct ggcatagcca gacatgggtt tctgtccatc 180 ttcctgaatg tgtaactctt cagcatctct atacttcctg actctcagct gccttcctcc 240 ttttgcccct catgggctgg caacacatag cttttcagac accttgttct cagaacccar 300 tgtgtttata caggttagag gagaaagtga tcggaagatc tcgaagtcaa tatagatatc 360 cttcacttgt tacccaagac aaacatggca aacacaacct tcactccagg gcttggagat 420 tagaatgaca gaattccctg gttgaactat ttcactggtc tttagtgggc attgtggaat 480 ggtgctattt ctaagcacat ggtcatatgt tcttctgagc tttctattca tgagacctca 540 ccacctccaa gtatcctcct acttctatca actatgagaa aagagagctg gcctgacat 599 <210> 171 <211 >599 <212> DNA <213> Homo sapiens <400> 171 tcttctcagc ctctagtacc ttctgtccta ctttttactt cctgtgttca actcttttag 60 ctgacacata tgagtgagaa catgcagtgc taacctttct gttcctggct tatttaacat 120 aatgtcctct aacgtcactc atgttactgt gaatgatagg attccattct ttttatggct 180 gaatagtatt ccatgatatg tatataccac attttcttta tccattcatg tgtggtcaga 240 caactaggtt gattccatgt cttggttatt gtgaagagag ctgcaataaa cctggggctk 300 cagatgactc tttgatataa tgatttccat tctgttagat aaagcccagt agtgagatag 360 ctggatcata tggtacttct atttgtagtt ttttaaggaa cctgcatact gttctccaga 420 gtgattgcgc agtttaaatt cctactaact atgtacaaaa gttccctttt tttctgcatc 480 ctcaccagca tgctattttt gtctttttga taatagccat ccttactggg gtgagaaaat 540 agctcattgt ggtttaggtt tgcatttctc tgaggattag tgatgttgag cacattttc 599 <210>172 <211 >599 <212> DNA <213> Homo sapiens <400> 172 gggcttcctc aggagaagag atggtctcat tgctcaggga accttttctc ctaggcaaac 60 agaggtagtg tggcagctgg aagaggcctg gagtggtact tggactttga agccaaacac 120 ttgccctctc agagcctttg cctccactgt ggtcctacca gagagctgag ttcaggacct 180 gggtttgggc gtggaagggc ggtgtgagag caaggctgaa tagtccaact tcctccttta 240 acaaatatcc actgagcgtc ttcgctacgc aaggctctct tccagaccgc ttggttcttw 300 ggagtccagg agttctccac tcggtacacc cagttttacc aaagttaaac ccatgagatt 360 ttgtaataaa gccaaggcta ataataatgc attccattac ttttcctaca catgtgtctc 420 tgttaagcac tttgcaagga ggatgggcag ctgggccaat gcaggatcca actattcaag 480 attcctccac ttacacaata tattgacact aactctgaat gcatccctac tgaatagaga 540 actctagtaa tttctactga aaacatcaaa taaaaaagct actactttaa tagaaatta 599
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This list of references cited by the applicant is for the reader's convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.
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Claims (8)
1. Fremgangsmåde til bestemmelse af en tilbøjelighed til myokardieinfarkt eller koronararteriesygdom i et menneskeligt individ fra en kaukasisk population, hvilken fremgangsmåde omfatter, at tilstedeværelsen eller fraværet af i det mindste én allel af mindst en polymorf markør i en nukleinsyreprøve opnået fra individet bestemmes, hvor den i det mindste ene polymorfe markør er valgt fra markøren rsll751605 samt markører i koblingsuligevægt med denne valgt fra gruppen bestående af markørerne angivet i tabel 5, og hvor tilstedeværelsen af den i det mindste ene allel indikerer en tilbøjelighed til myokardieinfarkt eller koronararteriesygdom hos personer fra en kaukasisk population.
2. Fremgangsmåde ifølge krav 1, hvor tilbøjeligheden, som skyldes tilstedeværelsen af den i det mindste ene allel, er øget modtagelighed.
3. Fremgangsmåde ifølge krav 1, hvor tilstedeværelsen af allellen C i rsll751605 indikerer øget tilbøjelighed til myokardieinfarkt eller koronararteriesygdom.
4. Fremgangsmåde ifølge et hvilket som helst af kravene 1-3, hvor tilstedeværelsen af markøren eller haplotypen er indikativ for en anden responsrate hos individet for en bestemt behandlingsmodalitet for myokardieinfarkt eller koronararteriesygdom.
5. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, som yderligere omfatter, at mindst én biomarkør i en prøve fra individet vurderes, hvor biomarkøren er en hjertemarkør eller en inflammatorisk markør valgt blandt kreatinkinase, troponin, glykogenphosphorylase, C-reaktivt protein (CRP), serum amyloid A, fibrinogen, interleukin-6, vævsnekrosefaktor-alfa, opløselige vaskulære celleadhæsionsmolekyler (sVCAM), opløselige intervaskulære adhæsionsmolekyler (sICAM), E-selektin, matrixmetalloprotease type 1, matrixmetalloprotease type 2 , matrixmetalloprotease type 3, matrixmetalloprotease type 9, serum sCD40L, leukotriener, leukotrienmetabolitter, interleukin-6, vævsnekrosefaktor-alfa, myeloperoxidase (MPO) og N-tyrosin.
6. Fremgangsmåde ifølge krav 5, hvor leukotrienet er valgt blandt LTB4, LTC4, LTD4 and LTE4.
7. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, som yderligere omfatter, at ikke-genetisk information analyseres for at foretage risikovurdering, diagnose eller prognose af individet, hvor den ikke-genetiske information er valgt blandt alder, køn, socioøkonomisk status, tidligere sygdomsdiagnose, individets sygdomshistorik, familiehistorik med hensyn til koronararteriesygdom eller myokardieinfarkt, biokemiske målinger og kliniske målinger.
8. Apparat til bestemmelse af en genetisk indikator for koronararteriesygdom eller myokardieinfarkt i et menneskeligt individ fra en kaukasisk population, hvilket apparat omfatter: en computerlæsbar hukommelse; og en rutine lagret i den computerlæsbare hukommelse; hvor rutinen er tilpasset til at kunne eksekveres på en processor for at analysere markør-og/eller haplotypeinformation for i det mindste ét menneskeligt individ med hensyn til i det mindste én polymorf markør, som er valgt fra markøren rsll751605 samt markører i koblingsuligevægt med denne valgt fra gruppen bestående af markørerne angivet i tabel 5, og generere et output baseret på markør- eller haplotypeinformationen, hvor outputtet omfatter et risikomål for den i det mindste ene markør eller haplotype som en genetisk indikator for koronararteriesygdom eller myokardieinfarkt hos det menneskelige individ.
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| BRPI0811309B1 (pt) * | 2007-05-09 | 2022-03-03 | The Brigham And Women's Hospital, Inc. | Métodos in vitro para avaliar uma responsividade do gene apo(a) em uma amostra de ácido nucleico de um indivíduo humano ao tratamento com ácido acetilsalicílico para reduzir o risco de um evento cardiovascular futuro |
| US20090226912A1 (en) * | 2007-12-21 | 2009-09-10 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| CN102803951A (zh) * | 2009-06-15 | 2012-11-28 | 心脏Dx公司 | 冠状动脉疾病风险的测定 |
| WO2012031207A2 (en) | 2010-09-03 | 2012-03-08 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| WO2012094366A1 (en) * | 2011-01-06 | 2012-07-12 | Cardiodx, Inc. | Circulating mirnas as biomarkers for coronary artery disease |
| US9534256B2 (en) | 2011-01-06 | 2017-01-03 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer |
| US8718950B2 (en) | 2011-07-08 | 2014-05-06 | The Medical College Of Wisconsin, Inc. | Methods and apparatus for identification of disease associated mutations |
| WO2013080227A1 (en) * | 2011-11-28 | 2013-06-06 | Decode Genetics Ehf | Genetic variants useful for risk assessment of arterial disease |
| CN107075563B (zh) * | 2014-09-30 | 2021-05-04 | 深圳华大基因科技有限公司 | 用于冠状动脉疾病的生物标记物 |
| US20220401388A1 (en) * | 2019-11-15 | 2022-12-22 | Institut De Cardiologie De Montreal | Methods for using low-dose colchicine after myocardial infarction |
| US20230307130A1 (en) * | 2020-11-08 | 2023-09-28 | The Johns Hopkins University | Methods and related aspects for analyzing chromosome number status |
| WO2022247903A1 (zh) * | 2021-05-26 | 2022-12-01 | 中国医学科学院阜外医院 | 冠心病多基因遗传风险评分及其构建方法与联合临床风险评估应用 |
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| DE3486467T3 (de) * | 1983-01-10 | 2004-10-14 | Gen-Probe Inc., San Diego | Verfahren zum Nachweis, Identifizieren und Quantifizieren von Organismen und Viren |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| EP0562025B1 (en) | 1990-12-06 | 2001-02-07 | Affymetrix, Inc. (a Delaware Corporation) | Compounds and their use in a binary synthesis strategy |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| JPH09507121A (ja) * | 1993-10-26 | 1997-07-22 | アフィマックス テクノロジーズ ナームロゼ ベノートスハップ | 生物学的チップ上の核酸プローブアレー |
| AU2003301305A1 (en) * | 2002-10-17 | 2004-05-04 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction; methods of treatment |
| CA2886504C (en) * | 2002-12-20 | 2019-01-08 | Celera Corporation | Wdr12 polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
| CA2518957A1 (en) * | 2003-03-10 | 2004-09-23 | Applera Corporation | Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
| CA2539276A1 (en) * | 2003-09-17 | 2005-03-31 | Decode Genetics Ehf. | Methods of preventing or treating recurrence of myocardial infarction |
| JP2009523006A (ja) * | 2004-05-07 | 2009-06-18 | アプレラ コーポレイション | 脈管疾患に関連する遺伝的多型、その検出方法および使用 |
| EP1745154B1 (en) * | 2004-05-07 | 2012-08-01 | Celera Corporation | Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof |
| WO2006099365A2 (en) * | 2005-03-11 | 2006-09-21 | Applera Corporation | Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof |
| WO2007006858A2 (en) * | 2005-07-12 | 2007-01-18 | Oy Jurilab Ltd | Method for treatment of cardiovascular and metabolic diseases and detecting the risk of the same |
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| EP2155907A2 (en) | 2010-02-24 |
| WO2008132763A3 (en) | 2008-12-18 |
| WO2008132763A2 (en) | 2008-11-06 |
| EP2155907B1 (en) | 2015-05-27 |
| US20100120045A1 (en) | 2010-05-13 |
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