ATE323113T1 - Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen - Google Patents

Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen

Info

Publication number
ATE323113T1
ATE323113T1 AT00943377T AT00943377T ATE323113T1 AT E323113 T1 ATE323113 T1 AT E323113T1 AT 00943377 T AT00943377 T AT 00943377T AT 00943377 T AT00943377 T AT 00943377T AT E323113 T1 ATE323113 T1 AT E323113T1
Authority
AT
Austria
Prior art keywords
water
polymers
soluble
probe
substrates
Prior art date
Application number
AT00943377T
Other languages
English (en)
Inventor
Gerrit Klaerner
Ralph B Nielsen
Paul Mansky
Didier Benoit
Dominique Charmot
Bernd Jandeleit
Laura T Mazzola
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/347,609 external-priority patent/US6472486B2/en
Priority claimed from US09/347,607 external-priority patent/US20020010267A1/en
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Application granted granted Critical
Publication of ATE323113T1 publication Critical patent/ATE323113T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/8305—Miscellaneous [e.g., treated surfaces, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
  • Dental Preparations (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
AT00943377T 1999-07-02 2000-07-03 Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen ATE323113T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US34760699A 1999-07-02 1999-07-02
US34760899A 1999-07-02 1999-07-02
US09/347,609 US6472486B2 (en) 1999-03-09 1999-07-02 Controlled stable free radical emulsion polymerization processes
US09/347,607 US20020010267A1 (en) 1999-03-09 1999-07-02 Block copolymers
US14693699P 1999-07-31 1999-07-31
US17787900P 2000-01-24 2000-01-24

Publications (1)

Publication Number Publication Date
ATE323113T1 true ATE323113T1 (de) 2006-04-15

Family

ID=27558334

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00943377T ATE323113T1 (de) 1999-07-02 2000-07-03 Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen

Country Status (7)

Country Link
US (3) US6692914B1 (de)
EP (1) EP1208126B1 (de)
AT (1) ATE323113T1 (de)
AU (1) AU5785400A (de)
CA (1) CA2377739A1 (de)
DE (1) DE60027309T2 (de)
WO (1) WO2001002452A1 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
CA2317179A1 (en) * 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US7163712B2 (en) * 2000-03-03 2007-01-16 Duke University Microstamping activated polymer surfaces
WO2001092361A1 (fr) * 2000-05-29 2001-12-06 Bio Merieux Polymere biocompatible pour la fixation de ligands biologiques
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
WO2001098765A1 (en) * 2000-06-21 2001-12-27 Bioarray Solutions, Ltd. Multianalyte molecular analysis
EP1202062B1 (de) * 2000-10-31 2007-02-28 Micronas GmbH Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung
AU2002246978A1 (en) * 2001-01-10 2002-07-24 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface
DE10102623C2 (de) * 2001-01-20 2003-04-10 Geesthacht Gkss Forschung Verfahren und Vorrichtung zur Bestimmung des Molekulargewichts von Polymeren
WO2002096977A1 (fr) * 2001-05-30 2002-12-05 Nanocarrier Co., Ltd. Procede de liaison d'une substance a incorporer a une terminaison polymere
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003001203A2 (en) 2001-06-22 2003-01-03 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US20030092062A1 (en) * 2001-10-24 2003-05-15 Reddy M. Parameswara Immobilizing biological molecules
US6927029B2 (en) * 2001-12-03 2005-08-09 Agilent Technologies, Inc. Surface with tethered polymeric species for binding biomolecules
EP1465933B1 (de) * 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymerkonjugate
US7138468B2 (en) * 2002-03-27 2006-11-21 University Of Southern Mississippi Preparation of transition metal nanoparticles and surfaces modified with (CO)polymers synthesized by RAFT
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
AU2003261220A1 (en) * 2002-07-19 2004-02-09 The Regents Of The University Of Colorado Fabrication of 3d photopolymeric devices
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
AU2002368411A1 (en) 2002-11-29 2004-06-23 Marcella Chiari Method for immobilizing biologic molecules on solid surfaces
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US20040191538A1 (en) * 2003-02-28 2004-09-30 Xueying Huang Nanometer-controlled polymeric thin films that resist adsorption of biological molecules and cells
DE10310193A1 (de) * 2003-03-06 2004-09-23 Micronas Holding Gmbh Verfahren zur Immobilisierung von Glykoproteinen
US6747104B1 (en) * 2003-03-21 2004-06-08 3M Innovative Properties Company Azlactone photoiniferters for radical polymerization
US6908952B2 (en) * 2003-03-21 2005-06-21 3M Innovative Properties Company Ring-opened azlactone photoiniferters for radical polymerization
JP4428616B2 (ja) * 2003-05-06 2010-03-10 オルガノ株式会社 グラフト修飾有機多孔質体及びその製造方法並びに吸着剤、クロマトグラフィー用充填剤及びイオン交換体
US7198855B2 (en) * 2003-09-12 2007-04-03 Becton, Dickinson And Company Methods of surface modification of a flexible substrate to enhance cell adhesion
WO2005029705A2 (en) * 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
US7595279B2 (en) * 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7309593B2 (en) 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US20050095602A1 (en) * 2003-11-04 2005-05-05 West Jason A. Microfluidic integrated microarrays for biological detection
US20050119589A1 (en) * 2003-11-14 2005-06-02 Tung Hsiaoho E. Rapid sample collection and analysis device and methods of use
US7795355B2 (en) * 2004-03-05 2010-09-14 Carnegie Mellon University Preparation of functional polymers
US7893174B2 (en) * 2004-03-05 2011-02-22 Carnegie Mellon University Atom transfer radical polymerization process
FR2867479B1 (fr) * 2004-03-15 2007-11-02 Commissariat Energie Atomique Polymere de haut poids moleculaire a base de n,n- dimethylacrylamide et de monomeres fonctionnalises par des molecules sondes et ses utilisations
DE112005000708B4 (de) 2004-03-30 2017-12-21 Relypsa, Inc. (n.d.Ges.d. Staates Delaware) Ionen bindende Zusammensetzung
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060160916A1 (en) * 2004-08-13 2006-07-20 Dyer Daniel J Process for modifying substrates with grafted polymers
CN104133060B (zh) * 2004-09-23 2016-06-29 三路影像公司 分析生物样品的方法
KR20070120605A (ko) 2005-04-14 2007-12-24 더 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 미세제작을 위한 희생층의 조절가능한 용해도
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8357433B2 (en) 2005-06-14 2013-01-22 Siemens Energy, Inc. Polymer brushes
EP1928919B1 (de) 2005-08-23 2010-02-17 Carnegie-Mellon University Radikalische atomtransfer-polymerisation in mikroemulsion und echte emulsionspolymerisation
US7893173B2 (en) * 2005-08-26 2011-02-22 Carnegie Mellon University Polymerization process with catalyst reactivation
BRPI0616604A2 (pt) 2005-09-30 2012-12-25 Ilypsa Inc mÉtodo para remover e composiÇço para seletivamente remover Íon de potÁssio do trato gastrintestinal de um mamÍfero, mÉtodo para seletivamente remover Íon de potÁssio de um meio-ambiente, composiÇço farmacÊutica, partÍcula de nécleo-envoltàrio, e, usos de uma partÍcula de nécleo-envoltàrio e de uma composiÇço farmacÊutica
CA2624112A1 (en) 2005-09-30 2007-04-05 Ilypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
CN101351260B (zh) * 2005-11-01 2011-12-21 西北大学 用于微通道分离的基质和动态聚合物体系和组合物
US8871155B2 (en) * 2005-11-30 2014-10-28 Alere Switzerland Gmbh Devices for detecting analytes in fluid sample
CA2630854C (en) * 2005-12-14 2016-01-26 Novartis Ag Method for preparing silicone hydrogels
US8778845B2 (en) * 2005-12-15 2014-07-15 Genral Electric Company Composition, device and associated method
US8741813B2 (en) * 2005-12-15 2014-06-03 General Electric Company Composition, device and associated method
WO2008014709A1 (fr) * 2006-07-26 2008-02-07 Abon Biopharm (Hangzhou) Co., Ltd. Dispositif d'analyse d'un échantillon biologique
US8367051B2 (en) * 2006-10-09 2013-02-05 Carnegie Mellon University Preparation of functional gel particles with a dual crosslink network
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8765643B2 (en) * 2006-12-04 2014-07-01 General Electric Company Composition, device and associated method
WO2008079677A2 (en) * 2006-12-20 2008-07-03 Arkema Inc. Polymer encapsulation and/or binding
US7994234B2 (en) * 2007-03-27 2011-08-09 Vanderbilt University Diamond polymer brushes
US8252880B2 (en) 2007-05-23 2012-08-28 Carnegie Mellon University Atom transfer dispersion polymerization
GB2463198B (en) * 2007-05-23 2013-05-22 Univ Carnegie Mellon Hybrid particle composite structures with reduced scattering
US8796184B2 (en) * 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
JP5384923B2 (ja) * 2008-12-05 2014-01-08 国立大学法人九州大学 高分子系ナノコンポジットの製造方法及び該製造方法によって形成された難燃性高分子系ナノコンポジット
WO2010111708A1 (en) 2009-03-27 2010-09-30 Carnegie Mellon University Preparation of functional star macromolecules
CN102200536B (zh) 2010-03-25 2015-05-27 艾博生物医药(杭州)有限公司 测试液体样本中被分析物的检测装置
WO2012079030A2 (en) * 2010-12-10 2012-06-14 The Regents Of The University Of California Bioconjugation using bifunctional linkers
US9644042B2 (en) 2010-12-17 2017-05-09 Carnegie Mellon University Electrochemically mediated atom transfer radical polymerization
WO2012152512A1 (en) * 2011-05-09 2012-11-15 The Swatch Group Research And Development Ltd Lubrication with oil-compatible polymer brushes
WO2013028756A1 (en) 2011-08-22 2013-02-28 Carnegie Mellon University Atom transfer radical polymerization under biologically compatible conditions
WO2013158183A2 (en) * 2012-01-27 2013-10-24 Carnegie Mellon University Processable self-organizing nanoparticles
US9533297B2 (en) 2012-02-23 2017-01-03 Carnegie Mellon University Ligands designed to provide highly active catalyst complexes
US9382387B2 (en) 2012-03-13 2016-07-05 California Institute Of Technology Rapid self-assembly of block copolymers to photonic crystals
US9045579B2 (en) 2012-03-13 2015-06-02 California Institute Of Technology Periodic nanostructures from self assembled wedge-type block-copolymers
US9453943B2 (en) 2012-06-28 2016-09-27 California Institute Of Technology Photonic structures from self assembly of brush block copolymers and polymer blends
KR102196230B1 (ko) 2012-09-17 2020-12-29 더블유.알. 그레이스 앤드 캄파니-콘. 크로마토그래피 매질 및 장치
CN104768536B (zh) 2012-09-17 2019-03-29 格雷斯公司 官能化微粒状载体材料和其制备和使用方法
CN102875195B (zh) * 2012-09-20 2014-03-12 华东理工大学 一种多重刺激响应聚合物刷膜的制备方法
WO2014075695A1 (en) * 2012-11-19 2014-05-22 Aarhus Universitet Joining of polymer and surface-modified solid part
EP3628747B1 (de) 2013-12-05 2022-10-05 Centrillion Technology Holdings Corporation Herstellung von gemusterten anordnungen
WO2015085274A1 (en) 2013-12-05 2015-06-11 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
CN105940024B (zh) * 2013-12-05 2019-03-15 生捷科技控股公司 修饰的表面
EP3094390B1 (de) 2014-01-16 2021-07-07 W.R. Grace & CO. - CONN. Affinitätschromatographiemedien und chromatographievorrichtungen
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
CN107847907A (zh) 2014-05-02 2018-03-27 格雷斯公司 官能化载体材料以及制备和使用官能化载体材料的方法
CN107073176B (zh) 2014-06-09 2021-02-19 康奈尔大学 可植入治疗递送系统及其方法
FR3026742B1 (fr) * 2014-10-03 2016-12-23 Alveole Impression d'un motif adhesif sur un support anti-salissures
US9982070B2 (en) 2015-01-12 2018-05-29 Carnegie Mellon University Aqueous ATRP in the presence of an activator regenerator
US10153513B2 (en) 2015-03-09 2018-12-11 California Institute Of Technology Triblock brush block copolymers
KR102566292B1 (ko) 2015-06-05 2023-08-10 더블유.알. 그레이스 앤드 캄파니-콘. 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법
US10733023B1 (en) * 2015-08-06 2020-08-04 D2Iq, Inc. Oversubscription scheduling
US11174325B2 (en) 2017-01-12 2021-11-16 Carnegie Mellon University Surfactant assisted formation of a catalyst complex for emulsion atom transfer radical polymerization processes
US11053356B2 (en) 2017-03-07 2021-07-06 California Institute Of Technology Control of polymer architectures by living ring-opening metathesis copolymerization
WO2018199181A1 (ja) * 2017-04-25 2018-11-01 国立大学法人京都大学 隙間狭小化材、隙間狭小化材複合体およびそれらを用いた物品
US20220332867A1 (en) * 2019-09-03 2022-10-20 Poliresin S.R.L. Hydroxyalkylamide functionalized acrylic polymers and process for manufacturing them
CN112174921B (zh) * 2020-09-29 2022-07-08 大连大学 基于香豆素和丹磺酰胺的谷胱甘肽荧光传感器分子及其制备方法
WO2022097048A1 (en) 2020-11-04 2022-05-12 Alcon Inc. Method for making photochromic contact lenses
EP4240579A1 (de) 2020-11-04 2023-09-13 Alcon Inc. Verfahren zur herstellung von photochromen kontaktlinsen
TW202408775A (zh) 2022-04-26 2024-03-01 瑞士商愛爾康公司 用於製造嵌入式水凝膠接觸鏡片之方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US526021A (en) * 1894-09-18 Pocket-transit
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US5512329A (en) 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4973493A (en) 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5217492A (en) 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4581429A (en) 1983-07-11 1986-04-08 Commonwealth Scientific And Industrial Research Organization Polymerization process and polymers produced thereby
EP0205232A1 (de) * 1985-04-08 1986-12-17 Kelsius, Inc. Signalverstärkung von optischen Fasern
US5354825A (en) * 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
DE3617672C2 (de) 1986-05-26 2000-02-17 Claus Heuck Verfahren zur Herstellung eines Reagenz, ein danach hergestelltes Reagenz sowie dessen Verwendung zur Bindung von Polymeren und Mikroorganismen aus wäßrigen Lösungen
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5240602A (en) * 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5258454A (en) 1988-09-01 1993-11-02 Riso National Laboratory Peptide synthesis method and solid support for use in the method
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
DE3921498A1 (de) 1988-09-28 1990-03-29 Bayer Ag Polymer-gebundene-farbstoffe, verfahren zu deren herstellung und verwendung
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5126021A (en) 1991-07-17 1992-06-30 Applied Biosystems Inc. Low-viscosity polymer solution for capillary electrophoresis
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix Inc N D Ges D Staat Verfahren zur Herstellung von Polymerarrays
WO1994021822A1 (en) 1993-03-19 1994-09-29 Sequenom, Inc. Dna sequencing by mass spectrometry via exonuclease degradation
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6027880A (en) 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
FR2716263B1 (fr) 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
EP0766705B1 (de) 1994-06-24 1998-05-13 The Dow Chemical Company Herstellung von amphipatischen pfropfcopolymeren, zusammensetzung davon und deren verwendung
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5530079A (en) 1995-01-03 1996-06-25 Xerox Corporation Polymerization processes
FR2730240A1 (fr) 1995-02-07 1996-08-09 Atochem Elf Sa Stabilisation d'un polymere par un radical libre stable
US6100026A (en) 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5753439A (en) 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US5942555A (en) 1996-03-21 1999-08-24 Surmodics, Inc. Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom
DK1005644T3 (da) 1996-04-25 2003-06-23 Pence Inc Biosensoranordning og fremgangsmåde
AU3568897A (en) 1996-06-07 1998-01-05 Eos Biotechnology, Inc. Immobilised linear oligonucleotide arrays
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
ATE234674T1 (de) 1996-11-14 2003-04-15 Affymetrix Inc Chemische amplifizierung zur synthese von musterordnungen
WO1998030601A2 (en) 1997-01-10 1998-07-16 E.I. Du Pont De Nemours And Company Method of controlling polymer molecular weight and structure
US5932711A (en) 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US5919626A (en) 1997-06-06 1999-07-06 Orchid Bio Computer, Inc. Attachment of unmodified nucleic acids to silanized solid phase surfaces
WO1999003894A1 (en) 1997-07-15 1999-01-28 Ciba Specialty Chemicals Holding Inc. Polymerizable compositions containing alkoxyamine compounds derived from nitroso- or nitrone compounds
US6391655B1 (en) 1997-07-30 2002-05-21 Corning Incorporated Oxidized styrenic polymers for DNA binding
US5858653A (en) 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
WO1999036571A2 (en) 1998-01-13 1999-07-22 Biochip Technologies Gmbh Method for the detection or nucleic acid of nucleic acid sequences
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
AU4218499A (en) 1998-05-27 1999-12-13 Syntrix Biochip Light-mediated method and apparatus for the regional analysis of biologic material
US6723517B1 (en) * 1998-06-02 2004-04-20 Minerva Biotechnologies Corporation Use of self-assembled monolayers to probe the structure of a target molecule
US6951682B1 (en) 1998-12-01 2005-10-04 Syntrix Biochip, Inc. Porous coatings bearing ligand arrays and use thereof
JP2002531470A (ja) 1998-12-01 2002-09-24 シントリクス バイオチップ， インコーポレイテッド 支持体表面上で化学反応のアレイを行うための方法および組成物
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
EP1035218A1 (de) 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilisierung von Molekülen an Oberflächen über verzweigte Polymerketten
AU3150400A (en) 1999-01-25 2000-08-07 Biochip Technologies Gmbh Immobilization of molecules on surfaces via polymer brushes
US6413587B1 (en) * 1999-03-02 2002-07-02 International Business Machines Corporation Method for forming polymer brush pattern on a substrate surface
CA2371011C (en) 1999-04-28 2009-12-22 Eidgenossisch Technische Hochschule Zurich Polyionic coatings in analytic and sensor devices
CA2317179A1 (en) 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
EP1095711B1 (de) 1999-10-27 2004-01-28 Novartis AG Verfahren für die Oberflächenbeschichtung von Materialien
US6077674A (en) 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity

Also Published As

Publication number Publication date
US6833276B2 (en) 2004-12-21
DE60027309D1 (de) 2006-05-24
US20020001845A1 (en) 2002-01-03
AU5785400A (en) 2001-01-22
US6692914B1 (en) 2004-02-17
WO2001002452A9 (en) 2002-07-25
US20050158879A1 (en) 2005-07-21
DE60027309T2 (de) 2006-08-31
WO2001002452A1 (en) 2001-01-11
EP1208126A1 (de) 2002-05-29
EP1208126B1 (de) 2006-04-12
CA2377739A1 (en) 2001-01-11

Similar Documents

Publication Publication Date Title
ATE323113T1 (de) Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
WO2002056021A3 (en) Polymer brushes for immobilizing molecules to a surface
ATE333517T1 (de) Verfahren und sondenset zur erkennung von krebs
ATE220341T1 (de) Verfahren zur trennung doppelsträngiger dna von einzelsträngiger dna oder rna
ATE238431T1 (de) Methode der veränderung der expression von genen bei der transkription und zum nachweis von chemischen substanzen, die wie modulatoren der genexpression wirken
ATE191237T1 (de) Verfahren zur immobilisierung von nukleinsäuresonden an polystyroloberflächen
DE69427103T2 (de) Verfahren, Reagenzien und Kits zur Untersuchung von Neisseria gonorrhoeae und Chlamydia trachomatis
DE69227997T2 (de) Verfahren mit einem gen-sonden biosensor
ATE270429T1 (de) Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen
ATE414171T1 (de) Verfahren zur immobilisierung von oligonukleotiden auf festem trägermaterial
ATE489482T1 (de) Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
DE59913128D1 (de) Material zur modifizierung der optischen eigenschaften unterschiedlicher zellen und gerät zum applizieren dieses materials
WO2003066906A3 (en) Diagnostic microarray and method of use thereof
ATE516492T1 (de) Vorrichtung und verfahren zur multianalytbestimmung
ATE441861T1 (de) Verfahren zum nachweis von analyten auf grundlage von evaneszenzbelichtung und auf streuung beruhender nachweis von nanopartikelsondenkomplexen
ATE230032T1 (de) Verfahren zur herstellung von festen trägern für hybridisierung und zur verminderung von nichtspezifischem hintergrund
SE9203435D0 (sv) Framstaellande av artificiella antikroppar med molekylavtrycksmetoden samt deras anvaendning vid analys
DE502005009522D1 (de) Verfahren zur kovalenten immobilisierung von biomolekülen an polymeren oberflächen
DE60332382D1 (de) Zentrifugalvorrichtung und verfahren zur durchführung von bindungsversuchen
EP1376124A3 (de) Nachweis von Toxinen und Screening von Verbindungen mit Hilfe von Microarrays biologischer Membranen
DE50114800D1 (de) Verfahren zur analyse von makromolekülen
ATE382713T1 (de) Verfahren und vorrichtung zum nachweis von biomolekülen
ATE70916T1 (de) Mit ueberzuegen versehene formkoerper zur bindung von bioaffinen substanzen.
ATE414097T1 (de) Verfahren zur herstellung von chemischen mikroarrays
DE60219429D1 (de) Biochemisches verfahren und vorrichtung zur bestimmung von eigenschaften von proteinen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties