ATE489482T1 - Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon - Google Patents
Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davonInfo
- Publication number
- ATE489482T1 ATE489482T1 AT06801832T AT06801832T ATE489482T1 AT E489482 T1 ATE489482 T1 AT E489482T1 AT 06801832 T AT06801832 T AT 06801832T AT 06801832 T AT06801832 T AT 06801832T AT E489482 T1 ATE489482 T1 AT E489482T1
- Authority
- AT
- Austria
- Prior art keywords
- antibodies
- capture probes
- capture
- bound
- dna
- Prior art date
Links
- 239000000758 substrate Substances 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 9
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 3
- 108091023037 Aptamer Proteins 0.000 abstract 2
- 239000012491 analyte Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
- B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70961305P | 2005-08-19 | 2005-08-19 | |
| PCT/US2006/032301 WO2007024676A2 (en) | 2005-08-19 | 2006-08-18 | Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE489482T1 true ATE489482T1 (de) | 2010-12-15 |
Family
ID=37533338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06801832T ATE489482T1 (de) | 2005-08-19 | 2006-08-18 | Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090111094A1 (de) |
| EP (1) | EP1915466B1 (de) |
| JP (1) | JP2009505106A (de) |
| AT (1) | ATE489482T1 (de) |
| DE (1) | DE602006018477D1 (de) |
| WO (1) | WO2007024676A2 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008275915B2 (en) * | 2007-07-17 | 2013-07-11 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
| US8852893B2 (en) * | 2007-09-14 | 2014-10-07 | Physicians Choice Laboratory Services, Llc | Detection of nucleic acids and proteins |
| JP2009085619A (ja) * | 2007-09-27 | 2009-04-23 | Tdk Corp | バイオセンサ |
| JP2010099061A (ja) * | 2008-09-26 | 2010-05-06 | Sekisui Chem Co Ltd | 検出用カートリッジ及び被検出物質の検出方法 |
| WO2010085548A2 (en) * | 2009-01-22 | 2010-07-29 | Li-Cor, Inc. | Single molecule proteomics with dynamic probes |
| JP5626673B2 (ja) * | 2009-03-12 | 2014-11-19 | 国立大学法人東京農工大学 | ジンクフィンガーを用いた新規標識方法及び被検物質の測定方法 |
| CN101967517B (zh) * | 2010-03-19 | 2012-11-07 | 黄乐群 | 一种无需借助pcr的基因检测方法 |
| US20130137090A1 (en) * | 2010-07-06 | 2013-05-30 | Aptateck Bio Ltd. | Nucleic acid aptamer-based diagnostic methods with novel techniques for signal enhancement |
| CN102147414B (zh) * | 2010-12-30 | 2013-07-03 | 中国科学院上海微系统与信息技术研究所 | 基于纳米探针的微流体芯片检测微量蛋白的方法 |
| AU2011352070A1 (en) | 2010-12-30 | 2013-07-18 | Foundation Medicine, Inc. | Optimization of multigene analysis of tumor samples |
| CN102520189A (zh) * | 2011-12-16 | 2012-06-27 | 首都医科大学 | 一个基于纳米技术的psa高敏感检测方法 |
| JP5566543B2 (ja) | 2012-03-30 | 2014-08-06 | 国立大学法人九州大学 | センサ、検出方法、検出システム、及び、検出装置 |
| KR101460439B1 (ko) | 2012-05-14 | 2014-11-12 | 서울대학교산학협력단 | 나노프로브 및 이를 이용한 표적 물질 검출방법 |
| WO2013184788A1 (en) * | 2012-06-05 | 2013-12-12 | Predictive Biosciences, Inc. | Detection of nucleic acids and proteins |
| IN2014DN11191A (de) * | 2012-07-06 | 2015-10-02 | Hitachi High Tech Corp | |
| KR101470730B1 (ko) * | 2013-04-24 | 2014-12-09 | 경희대학교 산학협력단 | 파장-의존성 플라즈몬 공명산란을 이용한 나노바이오칩 키트 및 이를 이용한 생체분자의 검출방법 |
| CN104458710B (zh) * | 2014-12-09 | 2017-11-14 | 山东省海盟生化科技有限公司 | 肿瘤早期高通量电化学发光检测方法的构建 |
| CA2986072C (en) | 2015-06-01 | 2023-05-02 | California Institute Of Technology | Compositions and methods for screening t cells with antigens for specific populations |
| US11041850B2 (en) | 2015-07-07 | 2021-06-22 | The Regents Of The University Of California | Method for detecting protein-specific glycosylation |
| CN105132533B (zh) * | 2015-07-24 | 2018-11-23 | 清华大学深圳研究生院 | 一种靶分子浓度的检测方法 |
| CA3043639A1 (en) | 2016-12-09 | 2018-06-14 | Ultivue, Inc. | Improved methods for multiplex imaging using labeled nucleic acid imaging agents |
| EP3592862A1 (de) | 2017-03-08 | 2020-01-15 | California Institute of Technology | Paarung der antigenspezifität einer t-zelle mit t-zell-rezeptor-sequenzen |
| EP3601339A4 (de) | 2017-03-31 | 2020-11-04 | Ultivue, Inc. | Dna-antigenaustausch und amplifikation |
| CN112567081A (zh) | 2018-06-11 | 2021-03-26 | 基础医疗股份有限公司 | 评价基因组改变的组合物和方法 |
| WO2020183015A1 (en) * | 2019-03-13 | 2020-09-17 | Evorion Biotechnologies Gmbh | Methods and kits for determining cell secreted biomolecules |
| WO2020223000A1 (en) * | 2019-04-30 | 2020-11-05 | Encodia, Inc. | Methods for preparing analytes and related kits |
| CN113825842A (zh) * | 2019-05-21 | 2021-12-21 | 凸版印刷株式会社 | 靶分子的检测方法 |
| CN110361433B (zh) * | 2019-07-04 | 2021-09-24 | 章毅 | 电化学检测细胞的方法及其组合物 |
| US20240353401A1 (en) * | 2020-08-18 | 2024-10-24 | Unicornfish Pty Ltd As Trustee For Rcx Unit Trust | Compositions and methods for detecting SARS-CoV-2 spike protein |
| US20230357822A1 (en) * | 2020-09-17 | 2023-11-09 | Evorion Biotechnologies Gmbh | Method for analyzing cell released biomolecules |
| JP2024524931A (ja) * | 2021-06-17 | 2024-07-09 | エフ． ホフマン－ラ ロシュ アーゲー | 脂質層上で免疫センシングするための方法 |
| CN117501122A (zh) * | 2021-06-17 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 用于使用磁性隧道结对脂质层进行免疫传感的方法 |
| EP4356133B1 (de) * | 2021-06-17 | 2025-07-30 | Roche Diagnostics GmbH | Verfahren zur immunmessung auf einer lipidschicht mittels magnetischer tunnelübergänge ii |
| US20230203595A1 (en) * | 2021-11-11 | 2023-06-29 | Korea University Research And Business Foundation | Surface-enhanced raman scattering (sers) biosensor for diagnosing prostate cancer with high sensitivity |
| KR102864797B1 (ko) * | 2021-11-11 | 2025-09-25 | 고려대학교 산학협력단 | 고감도 전립선암 진단용 표면-증강 라만 산란(sers) 바이오센서 |
| CN114199816B (zh) * | 2021-11-22 | 2023-11-03 | 湖北大学 | 基于近红外光激发检测生物标志物的光热传感器及其制备方法、在标志物检测中的应用 |
| GB2639519A (en) * | 2023-10-26 | 2025-10-01 | Todd Daniel | Nanites: smart, programmable polymer composite nucleic-acid nanostructures for sensitive, targeted, molecular nucleic acid detection |
| CN117871873A (zh) * | 2024-02-18 | 2024-04-12 | 河南省科学院物理研究所 | 一种基于高分子微球的显微暗场生物检测方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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-
2006
- 2006-08-18 DE DE602006018477T patent/DE602006018477D1/de active Active
- 2006-08-18 WO PCT/US2006/032301 patent/WO2007024676A2/en not_active Ceased
- 2006-08-18 US US11/506,280 patent/US20090111094A1/en not_active Abandoned
- 2006-08-18 EP EP06801832A patent/EP1915466B1/de not_active Not-in-force
- 2006-08-18 JP JP2008527164A patent/JP2009505106A/ja active Pending
- 2006-08-18 AT AT06801832T patent/ATE489482T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006018477D1 (de) | 2011-01-05 |
| WO2007024676A2 (en) | 2007-03-01 |
| EP1915466A2 (de) | 2008-04-30 |
| US20090111094A1 (en) | 2009-04-30 |
| EP1915466B1 (de) | 2010-11-24 |
| WO2007024676A3 (en) | 2007-06-07 |
| JP2009505106A (ja) | 2009-02-05 |
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