BR112018011475A2 - compostos e métodos para modulação de quinase e indicação para a mesma - Google Patents

compostos e métodos para modulação de quinase e indicação para a mesma

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Publication number
BR112018011475A2
BR112018011475A2 BR112018011475A BR112018011475A BR112018011475A2 BR 112018011475 A2 BR112018011475 A2 BR 112018011475A2 BR 112018011475 A BR112018011475 A BR 112018011475A BR 112018011475 A BR112018011475 A BR 112018011475A BR 112018011475 A2 BR112018011475 A2 BR 112018011475A2
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BR
Brazil
Prior art keywords
kinase
compounds
indication
methods
modulation
Prior art date
Application number
BR112018011475A
Other languages
English (en)
Inventor
Wu Guoxian
Lin Jack
Wu Jeffrey
Chan Katrina
dong Ken
N Ibrahim Prabha
Ewing Todd
Spevak Wayne
Zhang Ying
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of BR112018011475A2 publication Critical patent/BR112018011475A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

trata-se de compostos de fórmula i: i ou um sal, um solvato, um tautômero, um isômero ou um análogo deuterado farmaceuticamente aceitável dos mesmos, em que z2, z3 e z5 são conforme descrito no presente documento, composições dos mesmos e usos dos mesmos.
BR112018011475A 2015-12-07 2016-12-06 compostos e métodos para modulação de quinase e indicação para a mesma BR112018011475A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562264180P 2015-12-07 2015-12-07
PCT/US2016/065179 WO2017100201A1 (en) 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor

Publications (1)

Publication Number Publication Date
BR112018011475A2 true BR112018011475A2 (pt) 2018-12-04

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ID=57796966

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BR112018011475A BR112018011475A2 (pt) 2015-12-07 2016-12-06 compostos e métodos para modulação de quinase e indicação para a mesma

Country Status (16)

Country Link
US (1) US9938273B2 (pt)
EP (1) EP3386980B1 (pt)
JP (1) JP6862468B2 (pt)
KR (1) KR20180086247A (pt)
CN (1) CN108368110A (pt)
AU (1) AU2016367147B2 (pt)
BR (1) BR112018011475A2 (pt)
CA (1) CA3007462C (pt)
CO (1) CO2018007052A2 (pt)
ES (1) ES2899581T3 (pt)
IL (1) IL259803A (pt)
MX (1) MX2018006856A (pt)
PH (1) PH12018501179A1 (pt)
RU (1) RU2018123825A (pt)
SG (1) SG11201804711RA (pt)
WO (1) WO2017100201A1 (pt)

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