CO2018007052A2 - Compuestos y metodos para modulación de la quinasa, e indicaciones de los mismos - Google Patents

Compuestos y metodos para modulación de la quinasa, e indicaciones de los mismos

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Publication number
CO2018007052A2
CO2018007052A2 CONC2018/0007052A CO2018007052A CO2018007052A2 CO 2018007052 A2 CO2018007052 A2 CO 2018007052A2 CO 2018007052 A CO2018007052 A CO 2018007052A CO 2018007052 A2 CO2018007052 A2 CO 2018007052A2
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CO
Colombia
Prior art keywords
compounds
indications
methods
kinase modulation
kinase
Prior art date
Application number
CONC2018/0007052A
Other languages
English (en)
Inventor
Wayne Spevak
Katrina Chan
Guoxian Wu
Jeffrey Wu
Ken Dong
Todd Ewing
Jack Lin
Ying Zhang
Prabha N Ibrahim
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of CO2018007052A2 publication Critical patent/CO2018007052A2/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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Abstract

Se divulgan compuestos de Fórmula I, o una sal aceptable para uso farmacéutico, un solvato, un tautómero, un isómero o un análogo deuterado de los mismos, donde Z2, Z3, y Z5 son como se describen en la presente, composiciones de los mismos, y usos de los mismos.
CONC2018/0007052A 2015-12-07 2018-07-05 Compuestos y metodos para modulación de la quinasa, e indicaciones de los mismos CO2018007052A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562264180P 2015-12-07 2015-12-07
PCT/US2016/065179 WO2017100201A1 (en) 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor

Publications (1)

Publication Number Publication Date
CO2018007052A2 true CO2018007052A2 (es) 2018-07-19

Family

ID=57796966

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CONC2018/0007052A CO2018007052A2 (es) 2015-12-07 2018-07-05 Compuestos y metodos para modulación de la quinasa, e indicaciones de los mismos

Country Status (16)

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US (1) US9938273B2 (es)
EP (1) EP3386980B1 (es)
JP (1) JP6862468B2 (es)
KR (1) KR20180086247A (es)
CN (1) CN108368110A (es)
AU (1) AU2016367147B2 (es)
BR (1) BR112018011475A2 (es)
CA (1) CA3007462C (es)
CO (1) CO2018007052A2 (es)
ES (1) ES2899581T3 (es)
IL (1) IL259803A (es)
MX (1) MX2018006856A (es)
PH (1) PH12018501179A1 (es)
RU (1) RU2018123825A (es)
SG (1) SG11201804711RA (es)
WO (1) WO2017100201A1 (es)

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