MX2022006059A - Compuestos de arilo y heteroarilo, y usos terapeuticos de los mismos en condiciones asociadas con la alteracion de la actividad de galactocerebrosidasa. - Google Patents

Compuestos de arilo y heteroarilo, y usos terapeuticos de los mismos en condiciones asociadas con la alteracion de la actividad de galactocerebrosidasa.

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Publication number
MX2022006059A
MX2022006059A MX2022006059A MX2022006059A MX2022006059A MX 2022006059 A MX2022006059 A MX 2022006059A MX 2022006059 A MX2022006059 A MX 2022006059A MX 2022006059 A MX2022006059 A MX 2022006059A MX 2022006059 A MX2022006059 A MX 2022006059A
Authority
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Mexico
Prior art keywords
sup
galactocerebrosidase
alteration
aryl
activity
Prior art date
Application number
MX2022006059A
Other languages
English (en)
Inventor
Collazo Ana Maria Garcia
Jorda Elena Cubero
Alonso Xavier Barril
Manolo Bellotto
Original Assignee
Gain Therapeutics Sa
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Filing date
Publication date
Application filed by Gain Therapeutics Sa filed Critical Gain Therapeutics Sa
Publication of MX2022006059A publication Critical patent/MX2022006059A/es

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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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Abstract

La solicitud está dirigida a compuestos de las fórmulas (IA) y (IB): (ver Fórmulas) y sus sales y solvatos, en donde R1a, R2a, A1, A2, A3, A4, R1b, R2b, B1, B2, B3 y G son como se establece en la descripción, así como a l métodos para su preparación, a composiciones farmacéuticas que los comprenden, y al uso de los mismos para el tratamiento y/o prevención de, por ejemplo, enfermedades de depósito lisosomal, tal como la enfermedad de Krabbe, y a-sinucleinopatías, tal como la enfermedad de Parkinson.
MX2022006059A 2019-11-25 2020-11-25 Compuestos de arilo y heteroarilo, y usos terapeuticos de los mismos en condiciones asociadas con la alteracion de la actividad de galactocerebrosidasa. MX2022006059A (es)

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EP19383036 2019-11-25
PCT/IB2020/061156 WO2021105906A1 (en) 2019-11-25 2020-11-25 Aryl and heteroaryl compounds, and therapeutic uses thereof in conditions associated with the alteration of the activity of galactocerebrosidase

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CN (1) CN115397806A (es)
AU (1) AU2020393174A1 (es)
BR (1) BR112022010127A2 (es)
CA (1) CA3158290A1 (es)
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US4500714A (en) * 1981-10-15 1985-02-19 Chugai Seiyaku Kabushiki Kaisha 3-Substituted-ureido-N-pyridyl benzamides
WO2005049604A2 (en) * 2003-09-30 2005-06-02 Eli Lilly And Company Antithrombotic aromatic ethers
ES2580108T3 (es) * 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
EP2307440A4 (en) * 2008-07-01 2012-12-19 Zacharon Pharmaceuticals Inc HEPARAN SULFATE INHIBITORS
EP2411529A4 (en) * 2009-03-27 2012-09-19 Zacharon Pharmaceuticals Inc MODULATORS OF BIOSYNTHESIS OF N-BOUND GLYCANS
HUE028129T2 (en) 2009-10-19 2016-11-28 Amicus Therapeutics Inc New preparations for the prevention and / or treatment of lysosomal storage disorders
JP6117708B2 (ja) 2011-03-18 2017-04-19 ジェンザイム・コーポレーション グルコシルセラミド合成酵素阻害剤
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage
EP3126332A4 (en) * 2014-03-31 2017-09-06 The Trustees of Columbia University in the City of New York Histone acetyltransferase activators and uses thereof
CA3007462C (en) * 2015-12-07 2023-10-24 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US10160747B2 (en) * 2016-03-16 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
KR20190030693A (ko) * 2016-07-20 2019-03-22 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 히스톤 아세틸트랜스퍼라제 활성화제 및 이의 조성물 및 용도

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EP4065546A1 (en) 2022-10-05
CN115397806A (zh) 2022-11-25
AU2020393174A1 (en) 2022-06-30
JP2023503470A (ja) 2023-01-30
KR20220150880A (ko) 2022-11-11
BR112022010127A2 (pt) 2022-09-06
US20230058312A1 (en) 2023-02-23
IL293409A (en) 2022-07-01
CA3158290A1 (en) 2021-06-03

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