ATE56096T1 - Test zur sofortigen feststellung von liganden, testsatz und seine herstellung. - Google Patents

Test zur sofortigen feststellung von liganden, testsatz und seine herstellung.

Info

Publication number
ATE56096T1
ATE56096T1 AT84301769T AT84301769T ATE56096T1 AT E56096 T1 ATE56096 T1 AT E56096T1 AT 84301769 T AT84301769 T AT 84301769T AT 84301769 T AT84301769 T AT 84301769T AT E56096 T1 ATE56096 T1 AT E56096T1
Authority
AT
Austria
Prior art keywords
reactant
beads
fluorescer
test
ligand
Prior art date
Application number
AT84301769T
Other languages
English (en)
Inventor
Jacques Henri Bertoglio-Matte
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of ATE56096T1 publication Critical patent/ATE56096T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Saccharide Compounds (AREA)
AT84301769T 1984-03-15 1984-03-15 Test zur sofortigen feststellung von liganden, testsatz und seine herstellung. ATE56096T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP84301769A EP0154734B1 (de) 1984-03-15 1984-03-15 Test zur sofortigen Feststellung von Liganden, Testsatz und seine Herstellung

Publications (1)

Publication Number Publication Date
ATE56096T1 true ATE56096T1 (de) 1990-09-15

Family

ID=8192592

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84301769T ATE56096T1 (de) 1984-03-15 1984-03-15 Test zur sofortigen feststellung von liganden, testsatz und seine herstellung.

Country Status (4)

Country Link
EP (1) EP0154734B1 (de)
JP (1) JPH0654313B2 (de)
AT (1) ATE56096T1 (de)
DE (1) DE3483099D1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
GB8610426D0 (en) * 1986-04-29 1986-06-04 Leaback D H Bound assay components
US4943525A (en) * 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
SE8804657D0 (sv) * 1988-12-27 1988-12-27 Gerald Potter Colin Support structure for use in a proximity assey
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
CA2231385A1 (en) * 1995-09-15 1997-03-20 Merck & Co., Inc. A high throughput assay using fusion proteins
US6977141B2 (en) 1998-02-10 2005-12-20 Vicuron Pharmaceuticals Inc. Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
EP1195604A1 (de) 2000-09-29 2002-04-10 Warner-Lambert Company Verfahren und Zusammensetzungen zum Screenen von Modulatoren von Lipidkinasen
CN1539021A (zh) 2001-06-11 2004-10-20 Ӧ���о�ϵͳARS�ɷݹ�˾ 氨基糖苷结合分子的新型亲近闪烁检测法
SE0104102D0 (sv) 2001-12-05 2001-12-05 Astrazeneca Ab New assay
SE0104101D0 (sv) 2001-12-05 2001-12-05 Astrazeneca Ab New assay
BRPI0412684A (pt) 2003-07-17 2006-10-03 Plexxinko Inc compostos ppar-ativos
US7348338B2 (en) 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
JP2008503446A (ja) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド Ｐｄｅ４ｂ阻害剤及びその使用
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7927820B2 (en) 2004-07-20 2011-04-19 Janssen Pharmaceutica Nv Assay systems and methods for detecting molecules that interact with membrane channels
CN101048407A (zh) 2004-09-03 2007-10-03 普莱希科公司 双环杂芳基pde4b抑制剂
EP1819673A2 (de) 2004-11-30 2007-08-22 Plexxikon, Inc. Indolderivate zur verwendung als ppar-aktive verbindungen
AU2006272951A1 (en) 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
JP4652902B2 (ja) 2005-06-23 2011-03-16 株式会社日立ソリューションズ 安定保存された担体微小粒子
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
CA2836474A1 (en) 2011-05-17 2012-11-22 Plexxikon Inc. Kinase modulation and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US10160755B2 (en) 2015-04-08 2018-12-25 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US9938273B2 (en) 2015-12-07 2018-04-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TW201815766A (zh) 2016-09-22 2018-05-01 美商普雷辛肯公司 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症
JP7193460B2 (ja) 2016-12-23 2022-12-20 プレキシコン インコーポレーテッド Ｃｄｋ８調節およびその適応症のための化合物および方法
WO2018226846A1 (en) 2017-06-07 2018-12-13 Plexxikon Inc. Compounds and methods for kinase modulation
JP7636646B2 (ja) 2019-04-09 2025-02-27 オプナ バイオ ソシエテ アノニム Ｅｐ３００またはｃｂｐの調節のための縮合アジンおよびその適応
WO2021113625A1 (en) 2019-12-06 2021-06-10 Plexxikon Inc. Compounds and methods for cd73 modulation and indications therefor
US12667570B2 (en) 2020-01-08 2026-06-30 Icahn School Of Medicine At Mount Sinai Small molecule modulators of KSR-bound MEK
TW202204354A (zh) 2020-04-02 2022-02-01 美商普雷辛肯公司 用於ｃｓｋ調節之化合物及方法以及其說明
JP7842698B2 (ja) 2020-04-23 2026-04-08 オプナ バイオ ソシエテ アノニム Ｃｄ７３調節のための化合物及び方法並びにそれらの表示
WO2022061251A1 (en) 2020-09-18 2022-03-24 Plexxikon Inc. Compounds and methods for kras modulation and indications therefor
CN117956996A (zh) 2021-05-11 2024-04-30 Opna 生物公司 用于yap/tead调节的化合物和方法及其适应证
CA3263309A1 (en) 2022-08-22 2024-02-29 Iambic Therapeutics, Inc. HER2 COMPOUNDS AND MODULATION METHODS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000252A (en) * 1974-01-04 1976-12-28 Kenneth Kosak Immunoscintillation cell
SE7811630L (sv) * 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4382074A (en) * 1978-03-27 1983-05-03 Hiram Hart Scintillation proximity assay
US4259313A (en) * 1978-10-18 1981-03-31 Eastman Kodak Company Fluorescent labels
CA1185177A (en) * 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique

Also Published As

Publication number Publication date
EP0154734A1 (de) 1985-09-18
EP0154734B1 (de) 1990-08-29
JPS60196668A (ja) 1985-10-05
DE3483099D1 (de) 1990-10-04
JPH0654313B2 (ja) 1994-07-20

Similar Documents

Publication Publication Date Title
DE3483099D1 (de) Test zur sofortigen feststellung von liganden, testsatz und seine herstellung.
ATE452206T1 (de) Verfahren für verbesserte lumineszenztests unter verwendung von mikropartikeln
SE8205211D0 (sv) Forfarande for kvantitativ bestemning av en biospecifik affinitetsreaktion
DE3175729D1 (en) Improved method and device for use with automated chemical analyses
DE69229950D1 (de) Verfahren für verbesserte lumineszenz-assays unter verwendung von teilchenkonzentration und chemilumineszenznachweis
ATE81208T1 (de) Verfahren zum nachweis und zur quantitativbestimmung von immunologischen stoffen.
JPS6447952A (en) Immunoassay, reagent used therefor and making thereof
EP0193895A3 (de) Lumineszierendes Testverfahren
TR199802020T2 (xx) Bir ��zeltiye reaktif ilavesinin hesaplanmas�nda kullan�lan �l��m d�zenlemesi.
FI875609A7 (fi) Testikantaja kehon nesteiden ainesosasten analyyttistä määritystä varten.
DE69022578D1 (de) Test für Hepatitis-C.
DE3856567D1 (de) Lumineszente Rhenium-Komplexe und Verfahren zur Herstellung
FI831688L (fi) Test foer esterasaktivitet i ett flytande specimen
DE3270252D1 (en) Radioimmunoassay for fibrinopeptide a
SE8803602D0 (sv) A sample plate with a plurality of sample wells or vials intended for radiolabeled binding assays
GB2008247A (en) Detecting or quantifying substances using labelling techniques
DE3584023D1 (de) Verfahren zur durchfuehrung von immunfluoreszenztesten.
DE3683101D1 (de) Mit ueberzuegen versehene formkoerper zur bindung von bioaffinen substanzen.
GB1349491A (en) Fluorimetric assay of primary amino groups
DE69129035D1 (de) Testverfahren
JPS5714748A (en) Kit for quantitative determination of valproic acid and its method for quantitative determination
JPS6469951A (en) Carbon dioxide gas detection indicator
ES8601309A1 (es) Un metodo de medir un ligando biologico
JPS57149965A (en) Fluorescent immunoassay
US3403004A (en) Means and method for the detection of uranium

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time