ATE466106T1 - Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehen - Google Patents
Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehenInfo
- Publication number
- ATE466106T1 ATE466106T1 AT04765894T AT04765894T ATE466106T1 AT E466106 T1 ATE466106 T1 AT E466106T1 AT 04765894 T AT04765894 T AT 04765894T AT 04765894 T AT04765894 T AT 04765894T AT E466106 T1 ATE466106 T1 AT E466106T1
- Authority
- AT
- Austria
- Prior art keywords
- diagnosis
- diseases associated
- spondines
- futrins
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03023000 | 2003-10-10 | ||
PCT/EP2004/011269 WO2005040418A2 (en) | 2003-10-10 | 2004-10-08 | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE466106T1 true ATE466106T1 (de) | 2010-05-15 |
Family
ID=34486059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04765894T ATE466106T1 (de) | 2003-10-10 | 2004-10-08 | Zusammensetzungen für die diagnose und therapie von erkrankungen, die im zusammenhang mit einer anomalen expression von futrinen (r-spondinen) stehen |
Country Status (11)
Country | Link |
---|---|
US (8) | US9081011B2 (de) |
EP (3) | EP2093298A3 (de) |
AT (1) | ATE466106T1 (de) |
CY (1) | CY1114679T1 (de) |
DE (1) | DE602004026898D1 (de) |
DK (2) | DK1673475T3 (de) |
ES (2) | ES2345256T3 (de) |
PL (1) | PL2157192T3 (de) |
PT (1) | PT2157192E (de) |
SI (1) | SI2157192T1 (de) |
WO (1) | WO2005040418A2 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7294704B2 (en) | 2003-08-15 | 2007-11-13 | Diadexus, Inc. | Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk |
DK1673475T3 (da) | 2003-10-10 | 2010-07-19 | Deutsches Krebsforsch | Sammensætninger til diagnose og terapi af sygdomme, som er forbundet med aberrant ekspression af futriner (R-Spondiner) og/eller Wnt |
CA2554403A1 (en) * | 2004-01-27 | 2005-08-11 | Nuvelo, Inc. | Gastrointestinal proliferative factor and uses thereof |
US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
SI2081586T2 (sl) * | 2006-10-20 | 2019-01-31 | Deutsches Krebsforschungszentrum, Stiftung Des Oeffentlichen Rechts | Rspondini kot modulatorji angiogeneze in vaskulogeneze |
WO2008088524A2 (en) * | 2006-12-28 | 2008-07-24 | Nuvelo, Inc. | Thrombospondin-domain-deficient r-spondin 1 protein as gastrointestinal tract epithelial proliferation factor |
PL3009148T3 (pl) | 2007-07-02 | 2019-03-29 | Oncomed Pharmaceuticals, Inc. | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
AU2013203352B2 (en) * | 2007-07-02 | 2016-10-27 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
EP3441458B9 (de) | 2009-02-03 | 2023-08-23 | Koninklijke Nederlandse Akademie van Wetenschappen | Nährmedium für epithelstammzellen und organelle mit den besagten stammzellen |
EP2412800A1 (de) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Leberorganoid, Verwendungen davon und Kultivierungsverfahren zum Erhalten davon |
US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
WO2010121923A1 (en) | 2009-04-15 | 2010-10-28 | Deutsches Krebsforschungszentrum | Rspondin-3 inhibition in bone disorders |
EP2494349A4 (de) * | 2009-09-29 | 2013-08-07 | Dart Neuroscience Cayman Ltd | Gene, verfahren und zusammensetzungen in zusammenhang mit neurogenese und ihrer modulation |
EP2977060A1 (de) * | 2009-12-23 | 2016-01-27 | Deutsches Krebsforschungszentrum | Rspo2- und rspo3-rezeptoren |
CA2841745A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
AU2013204484B2 (en) * | 2011-07-15 | 2016-05-12 | Oncomed Pharmaceuticals, Inc. | RSPO binding agents and uses thereof |
BR112014019741A2 (pt) | 2012-02-11 | 2020-12-22 | Genentech, Inc | Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado |
WO2014012007A2 (en) | 2012-07-13 | 2014-01-16 | Oncomed Pharmaceuticals, Inc. | Rspo3 binding agents and uses thereof |
CA2905830C (en) | 2013-03-12 | 2022-01-18 | Curegenix Inc. | Quinazoline and naphthyridine derivatives useful in the treatment of cancer |
MX2016004802A (es) | 2013-10-18 | 2016-07-18 | Genentech Inc | Anticuerpos anti-r-espondina (anti-rspo) y metodos de uso. |
EP3193935A4 (de) | 2014-09-16 | 2018-03-21 | Oncomed Pharmaceuticals, Inc. | Behandlung von fibrotischen erkrankungen |
WO2017095918A2 (en) * | 2015-12-01 | 2017-06-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer using rspo3 antagonists |
EP3443004A1 (de) | 2016-04-14 | 2019-02-20 | H. Hoffnabb-La Roche Ag | Anti-rspo3-antikörper und verfahren zur verwendung |
WO2018132572A1 (en) | 2017-01-11 | 2018-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | R-spondin (rspo) surrogate molecules |
WO2018140821A1 (en) * | 2017-01-26 | 2018-08-02 | Surrozen, Inc. | Tissue-specific wnt signal enhancing molecules and uses thereof |
CN110218740A (zh) * | 2019-05-17 | 2019-09-10 | 深圳先进技术研究院 | 一种用于快速检测经典Wnt信号通路活性的脑血管内皮细胞系 |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
JPH06504997A (ja) | 1990-12-06 | 1994-06-09 | アフィメトリックス, インコーポレイテッド | 非常に大きい規模の固定化されたポリマーの合成 |
US5322933A (en) | 1992-05-07 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Crystal structure of TGF-β-2 |
WO2003094843A2 (en) | 2002-05-10 | 2003-11-20 | Incyte Corporation | Cell adhesion and extracellular matrix proteins |
WO1994029469A2 (en) | 1993-06-07 | 1994-12-22 | Vical Incorporated | Plasmids suitable for gene therapy |
US5856116A (en) | 1994-06-17 | 1999-01-05 | Vertex Pharmaceuticals, Incorporated | Crystal structure and mutants of interleukin-1 beta converting enzyme |
JPH11509088A (ja) | 1995-06-23 | 1999-08-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 血管内皮増殖因子受容体をコードする遺伝子の転写調節 |
WO1998018947A1 (en) | 1996-10-31 | 1998-05-07 | Smithkline Beecham Corporation | Methods for the characterization and selection of rna target motifs that bind compounds of pharmaceutical use |
WO1998041539A2 (en) | 1997-03-19 | 1998-09-24 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
JP2001527403A (ja) | 1997-04-25 | 2001-12-25 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌蛋白およびそれらをコードするポリヌクレオチド |
US20020065394A1 (en) | 1998-03-18 | 2002-05-30 | Kenneth Jacobs | Secreted proteins and polynucleotides encoding them |
US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
GB9828419D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel compounds |
JP2003505082A (ja) | 1999-07-26 | 2003-02-12 | ジェネンテック・インコーポレーテッド | 新規なポリヌクレオチドとその使用法 |
AU6181000A (en) | 1999-07-29 | 2001-02-19 | Chugai Research Institute For Molecular Medicine, Inc. | Novel genes encoding protein kinase/protein phosphatase |
US6824973B2 (en) | 2000-02-03 | 2004-11-30 | Kirin Beer Kabushiki Kaisha | Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide |
US6653448B1 (en) * | 2000-03-29 | 2003-11-25 | Curagen Corporation | Wnt-7B-like polypeptides and nucleic acids encoding same |
AU5301201A (en) | 2000-03-31 | 2001-10-15 | Gen Hospital Corp | Methods of modulating hair growth |
WO2001077169A2 (en) | 2000-04-05 | 2001-10-18 | Kirin Beer Kabushiki Kaisha | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
US20030022255A1 (en) | 2000-12-22 | 2003-01-30 | Morris David W. | Novel compositions and methods for breast cancer |
US20040077048A1 (en) | 2002-01-30 | 2004-04-22 | Warren Bridget A. | Protein modification and maintenance molecules |
JP2005503108A (ja) * | 2001-01-31 | 2005-02-03 | インサイト・ゲノミックス・インコーポレイテッド | タンパク質修飾およびメンテナンス分子 |
US20030165501A1 (en) | 2001-02-16 | 2003-09-04 | Genentech, Inc. | Treatment involving Dkk-1 or antagonists thereof |
US20100305003A1 (en) * | 2001-03-05 | 2010-12-02 | Arca Biopharma Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
US7411052B2 (en) | 2001-03-05 | 2008-08-12 | Nuvelo, Inc. | Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides |
EP1383789A2 (de) | 2001-04-06 | 2004-01-28 | Incyte Genomics, Inc. | Mit zellwachstum, -differenzierung und -tod assoziierte proteine |
WO2002100898A2 (en) | 2001-06-11 | 2002-12-19 | Kirin Beer Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same |
US20030022217A1 (en) | 2001-07-02 | 2003-01-30 | Pe Corporation (Ny) | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
WO2003027230A2 (en) | 2001-08-03 | 2003-04-03 | Incyte Genomics, Inc. | Cell adhesion and extracellular matrix proteins |
EP1427747B1 (de) | 2001-08-30 | 2012-04-11 | ARCA biopharma, Inc. | Verfahren und materialien in verbindung mit stammzellen-wachstumsfaktor-ähnlichen polypeptiden und polynukleotiden |
WO2003025142A2 (en) | 2001-09-16 | 2003-03-27 | Nuvelo, Inc. | Novel nucleic acids and secreted polypeptides |
WO2003025143A2 (en) | 2001-09-19 | 2003-03-27 | The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Maxp1 |
US7439332B2 (en) | 2002-04-26 | 2008-10-21 | Kirin Pharma Kabushiki Kaisha | Polypeptide having an activity to support proliferation or survival of hematopoietic stem or progenitor cells |
CA2500521A1 (en) | 2002-10-02 | 2004-09-23 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
WO2004099408A1 (ja) | 2003-05-09 | 2004-11-18 | Research Association For Biotechnology | 新規蛋白質およびそれをコードするdna |
WO2005110009A2 (en) | 2003-07-22 | 2005-11-24 | Immunex Corporation | COMPOSITIONS AND METHODS RELATING TO TSP-30a, b, c AND d |
DK1673475T3 (da) | 2003-10-10 | 2010-07-19 | Deutsches Krebsforsch | Sammensætninger til diagnose og terapi af sygdomme, som er forbundet med aberrant ekspression af futriner (R-Spondiner) og/eller Wnt |
WO2005071058A2 (en) | 2004-01-27 | 2005-08-04 | Compugen Ltd. | Methods and systems for annotating biomolecular sequences |
CA2554403A1 (en) | 2004-01-27 | 2005-08-11 | Nuvelo, Inc. | Gastrointestinal proliferative factor and uses thereof |
US7439327B2 (en) | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
WO2007013666A2 (en) | 2005-07-26 | 2007-02-01 | Kirin Pharma Kabushiki Kaisha | Anti-tumor agents comprising r-spondins |
US7541431B2 (en) | 2005-09-07 | 2009-06-02 | Maine Medical Center | Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto |
WO2007100357A2 (en) | 2005-10-07 | 2007-09-07 | Nuvelo, Inc. | Stem cell factor-like protein scfa1 and uses thereof |
SI2081586T2 (sl) | 2006-10-20 | 2019-01-31 | Deutsches Krebsforschungszentrum, Stiftung Des Oeffentlichen Rechts | Rspondini kot modulatorji angiogeneze in vaskulogeneze |
PL3009148T3 (pl) | 2007-07-02 | 2019-03-29 | Oncomed Pharmaceuticals, Inc. | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
WO2010121923A1 (en) | 2009-04-15 | 2010-10-28 | Deutsches Krebsforschungszentrum | Rspondin-3 inhibition in bone disorders |
US20120165270A1 (en) | 2009-04-27 | 2012-06-28 | Yeon Sook Choi | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
EP2977060A1 (de) | 2009-12-23 | 2016-01-27 | Deutsches Krebsforschungszentrum | Rspo2- und rspo3-rezeptoren |
GB201106395D0 (en) * | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
CA2841745A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
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2004
- 2004-10-08 DK DK04765894.3T patent/DK1673475T3/da active
- 2004-10-08 ES ES04765894T patent/ES2345256T3/es active Active
- 2004-10-08 WO PCT/EP2004/011269 patent/WO2005040418A2/en active Application Filing
- 2004-10-08 EP EP09002213A patent/EP2093298A3/de not_active Withdrawn
- 2004-10-08 US US10/575,217 patent/US9081011B2/en not_active Expired - Fee Related
- 2004-10-08 DK DK09170230.8T patent/DK2157192T3/da active
- 2004-10-08 DE DE602004026898T patent/DE602004026898D1/de active Active
- 2004-10-08 PT PT91702308T patent/PT2157192E/pt unknown
- 2004-10-08 ES ES09170230.8T patent/ES2437337T3/es active Active
- 2004-10-08 EP EP04765894A patent/EP1673475B1/de not_active Not-in-force
- 2004-10-08 SI SI200432095T patent/SI2157192T1/sl unknown
- 2004-10-08 EP EP09170230.8A patent/EP2157192B1/de not_active Revoked
- 2004-10-08 PL PL09170230T patent/PL2157192T3/pl unknown
- 2004-10-08 AT AT04765894T patent/ATE466106T1/de active
-
2013
- 2013-06-28 US US13/931,481 patent/US20130337533A1/en not_active Abandoned
- 2013-07-19 US US13/946,907 patent/US20140134703A1/en not_active Abandoned
- 2013-07-25 US US13/951,152 patent/US20140186917A1/en not_active Abandoned
- 2013-11-27 CY CY20131101060T patent/CY1114679T1/el unknown
-
2014
- 2014-04-04 US US14/245,897 patent/US8951745B2/en not_active Expired - Fee Related
- 2014-04-04 US US14/245,807 patent/US8921056B2/en not_active Expired - Fee Related
-
2015
- 2015-12-23 US US14/757,390 patent/US20160376349A1/en not_active Abandoned
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2018
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Also Published As
Publication number | Publication date |
---|---|
US20190194306A1 (en) | 2019-06-27 |
EP2093298A2 (de) | 2009-08-26 |
EP1673475A2 (de) | 2006-06-28 |
US20140186917A1 (en) | 2014-07-03 |
US20130337533A1 (en) | 2013-12-19 |
CY1114679T1 (el) | 2016-10-05 |
PT2157192E (pt) | 2013-11-28 |
WO2005040418A3 (en) | 2005-11-10 |
US20070244061A1 (en) | 2007-10-18 |
WO2005040418A2 (en) | 2005-05-06 |
ES2345256T3 (es) | 2010-09-20 |
EP2093298A3 (de) | 2009-09-23 |
US20160376349A1 (en) | 2016-12-29 |
EP2157192B1 (de) | 2013-08-28 |
US8921056B2 (en) | 2014-12-30 |
DK2157192T3 (da) | 2013-11-25 |
US8951745B2 (en) | 2015-02-10 |
US20140357510A1 (en) | 2014-12-04 |
EP1673475B1 (de) | 2010-04-28 |
US9081011B2 (en) | 2015-07-14 |
US20140134703A1 (en) | 2014-05-15 |
DE602004026898D1 (de) | 2010-06-10 |
PL2157192T3 (pl) | 2014-01-31 |
SI2157192T1 (sl) | 2013-11-29 |
US20140227713A1 (en) | 2014-08-14 |
ES2437337T3 (es) | 2014-01-10 |
DK1673475T3 (da) | 2010-07-19 |
EP2157192A1 (de) | 2010-02-24 |
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