CY1114679T1 - Συνθεσεις για διαγνωση και θεραπεια ασθενειων που συνδυαζονται με παρεκκλινουσα εκφραση φουτρινων (r-σπονδινων) - Google Patents
Συνθεσεις για διαγνωση και θεραπεια ασθενειων που συνδυαζονται με παρεκκλινουσα εκφραση φουτρινων (r-σπονδινων)Info
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- CY1114679T1 CY1114679T1 CY20131101060T CY131101060T CY1114679T1 CY 1114679 T1 CY1114679 T1 CY 1114679T1 CY 20131101060 T CY20131101060 T CY 20131101060T CY 131101060 T CY131101060 T CY 131101060T CY 1114679 T1 CY1114679 T1 CY 1114679T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
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- Urology & Nephrology (AREA)
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- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε μια σύνθεση χρήσιμη για τη διάγνωση ασθενειών που συνδυάζονται με παρεκκλίνουσα έκφραση των γονιδίων που κωδικοποιούν τις εκκρινόμενες πρωτεΐνες Φουτρίνη 1, 2, 3 ή/και 4(= R-Σπονδίνη 2, 3, 1 και 4, αντιστοίχως), π.χ. σε σχέση με όγκους ή ασθένειες του μυός, των νεφρών ή τον οστών. Η παρούσα εφεύρεση επίσης αφορά σε μία φαρμακευτική σύνθεση περιέχουσα μία ένωση, η οποία είναι ικανή τροποποίησης (a) της έκφρασης του γονιδίου που κωδικοποιεί Φουτρίνη 1, 2, 3 ή/και 4 ή (b) της δραστικότητας της πρωτεΐνης Φουτρίνη 1, 2, 3 ή/και 4 .
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03023000 | 2003-10-10 | ||
EP09170230.8A EP2157192B1 (en) | 2003-10-10 | 2004-10-08 | Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (R-Spondins) |
Publications (1)
Publication Number | Publication Date |
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CY1114679T1 true CY1114679T1 (el) | 2016-10-05 |
Family
ID=34486059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20131101060T CY1114679T1 (el) | 2003-10-10 | 2013-11-27 | Συνθεσεις για διαγνωση και θεραπεια ασθενειων που συνδυαζονται με παρεκκλινουσα εκφραση φουτρινων (r-σπονδινων) |
Country Status (11)
Country | Link |
---|---|
US (8) | US9081011B2 (el) |
EP (3) | EP2093298A3 (el) |
AT (1) | ATE466106T1 (el) |
CY (1) | CY1114679T1 (el) |
DE (1) | DE602004026898D1 (el) |
DK (2) | DK1673475T3 (el) |
ES (2) | ES2345256T3 (el) |
PL (1) | PL2157192T3 (el) |
PT (1) | PT2157192E (el) |
SI (1) | SI2157192T1 (el) |
WO (1) | WO2005040418A2 (el) |
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PL3009148T3 (pl) | 2007-07-02 | 2019-03-29 | Oncomed Pharmaceuticals, Inc. | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
WO2010121923A1 (en) | 2009-04-15 | 2010-10-28 | Deutsches Krebsforschungszentrum | Rspondin-3 inhibition in bone disorders |
US20120165270A1 (en) | 2009-04-27 | 2012-06-28 | Yeon Sook Choi | Inhibition of hair follicle growth by the wnt inhibitor dkk1 |
EP2977060A1 (en) | 2009-12-23 | 2016-01-27 | Deutsches Krebsforschungszentrum | Receptors of rspo2 and rspo3 |
GB201106395D0 (en) * | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
CA2841745A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
-
2004
- 2004-10-08 DK DK04765894.3T patent/DK1673475T3/da active
- 2004-10-08 ES ES04765894T patent/ES2345256T3/es active Active
- 2004-10-08 WO PCT/EP2004/011269 patent/WO2005040418A2/en active Application Filing
- 2004-10-08 EP EP09002213A patent/EP2093298A3/en not_active Withdrawn
- 2004-10-08 US US10/575,217 patent/US9081011B2/en not_active Expired - Fee Related
- 2004-10-08 DK DK09170230.8T patent/DK2157192T3/da active
- 2004-10-08 DE DE602004026898T patent/DE602004026898D1/de active Active
- 2004-10-08 PT PT91702308T patent/PT2157192E/pt unknown
- 2004-10-08 ES ES09170230.8T patent/ES2437337T3/es active Active
- 2004-10-08 EP EP04765894A patent/EP1673475B1/en not_active Not-in-force
- 2004-10-08 SI SI200432095T patent/SI2157192T1/sl unknown
- 2004-10-08 EP EP09170230.8A patent/EP2157192B1/en not_active Revoked
- 2004-10-08 PL PL09170230T patent/PL2157192T3/pl unknown
- 2004-10-08 AT AT04765894T patent/ATE466106T1/de active
-
2013
- 2013-06-28 US US13/931,481 patent/US20130337533A1/en not_active Abandoned
- 2013-07-19 US US13/946,907 patent/US20140134703A1/en not_active Abandoned
- 2013-07-25 US US13/951,152 patent/US20140186917A1/en not_active Abandoned
- 2013-11-27 CY CY20131101060T patent/CY1114679T1/el unknown
-
2014
- 2014-04-04 US US14/245,897 patent/US8951745B2/en not_active Expired - Fee Related
- 2014-04-04 US US14/245,807 patent/US8921056B2/en not_active Expired - Fee Related
-
2015
- 2015-12-23 US US14/757,390 patent/US20160376349A1/en not_active Abandoned
-
2018
- 2018-12-18 US US16/224,230 patent/US20190194306A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20190194306A1 (en) | 2019-06-27 |
EP2093298A2 (en) | 2009-08-26 |
EP1673475A2 (en) | 2006-06-28 |
US20140186917A1 (en) | 2014-07-03 |
US20130337533A1 (en) | 2013-12-19 |
PT2157192E (pt) | 2013-11-28 |
WO2005040418A3 (en) | 2005-11-10 |
US20070244061A1 (en) | 2007-10-18 |
WO2005040418A2 (en) | 2005-05-06 |
ES2345256T3 (es) | 2010-09-20 |
EP2093298A3 (en) | 2009-09-23 |
US20160376349A1 (en) | 2016-12-29 |
EP2157192B1 (en) | 2013-08-28 |
US8921056B2 (en) | 2014-12-30 |
DK2157192T3 (da) | 2013-11-25 |
US8951745B2 (en) | 2015-02-10 |
US20140357510A1 (en) | 2014-12-04 |
ATE466106T1 (de) | 2010-05-15 |
EP1673475B1 (en) | 2010-04-28 |
US9081011B2 (en) | 2015-07-14 |
US20140134703A1 (en) | 2014-05-15 |
DE602004026898D1 (de) | 2010-06-10 |
PL2157192T3 (pl) | 2014-01-31 |
SI2157192T1 (sl) | 2013-11-29 |
US20140227713A1 (en) | 2014-08-14 |
ES2437337T3 (es) | 2014-01-10 |
DK1673475T3 (da) | 2010-07-19 |
EP2157192A1 (en) | 2010-02-24 |
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