FI112033B - Förfarande för framställning av terapeutiska användbara immunologiskt aktiva, chimera antikroppar, vilka spesifikt binder CD20-antigenen - Google Patents

Förfarande för framställning av terapeutiska användbara immunologiskt aktiva, chimera antikroppar, vilka spesifikt binder CD20-antigenen Download PDF

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Publication number
FI112033B
FI112033B FI952327A FI952327A FI112033B FI 112033 B FI112033 B FI 112033B FI 952327 A FI952327 A FI 952327A FI 952327 A FI952327 A FI 952327A FI 112033 B FI112033 B FI 112033B
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Finland
Prior art keywords
antibody
cells
cell
chimeric
antibodies
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FI952327A
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English (en)
Finnish (fi)
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FI952327A0 (sv
FI952327A (sv
Inventor
Nabil Hanna
William H Rastetter
John E Leonard
Roland A Newman
Darrell R Anderson
Mitchell E Reff
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Idec Pharma Corp
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Priority claimed from US08/149,099 external-priority patent/US5736137A/en
Application filed by Idec Pharma Corp filed Critical Idec Pharma Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology

Claims (15)

1. Förfarande för framställning av en terapeutiskt användbar, immunologiskt aktiv, chimär antikropp, vilken 5 specifikt binder CD20-antigenen, kännetecknat av att man (i) erhaller en värdcell som innehäller DNA- sekvenser vilka kodar för expressionen av den chimära anti-CD20-antikroppen producerad av det med depositionsnummer
2. Förfarande enligt patentkrav 1, känne tecknat av att nämnda värdcell är en däggdjurscell.
3. Förfarande enligt patentkrav 2, känne tecknat av att nämnda värdcell är en CHO-cell. 20
4. Förfarande enligt patentkrav 1, känne tecknat av att nämnda DNA-sekvenser förs i nämnda , värdcell genom användning av en plasmiduttrycksvektor, sä- som plasmiduttrycksvektorn enligt figur 1.
.’* » 5. Förfarande enligt patentkrav 1, k ä n n e - , : 25 tecknat av att det ytterligare innehäller ett steg väri man bildar en sammansättning som innehäller nämnda chimära anti-CD20-antikropp med en farmaceutiskt godtagbar bärare.
6. Förfarande enligt patentkrav 1, k ä n n e - ! 30 tecknat av att värdcellen är ATCC 69119.
7. Förfarande enligt patentkrav 1, k ä n n e - •y. tecknat av att det ytterligare innehäller ett steg väri nämnda antikropp stämplas med en radioaktiv stämpel.
8. Förfarande enligt patentkrav 7, k ä n n e - . ” 35 tecknat av att nämnda radiostämpel är yttrium(90), ' » » ·...· indium (111) eller jod(131). 112033
9. Förfarande för framställning av en terapeutiskt användbar monoklonal mus-anti-CD20-antikropp, kanne -tecknat av att man (i) immuniserar en mus med en human CD20-antigen, 5 (ii) isolerar immunceller som producerar specifikä antikroppar mot CD20-antigenet frän nämnda mus, (iii) fusionerar nämnda immunceller med kontinuer-ligt fördelande celler för att producera ett hybridom, (iv) väljer ett hybridom som producerar en mus-10 anti-CD2 0-antikropp som produceras av det i ATCC- depositionsinstitutionen deponerade hybridomet HB 11388, och (v) isolerar mus-anti-CD20-antikroppen producerad av nämnda hybridom. 15 10. Förfarande enligt patentkrav 9, k ä n n e - tecknat av att det ytterligare innehäller ett steg väri den isolerade mus-anti-CD20-antikroppen förenas med en farmaceutiskt godtagbar bärare.
10 ATCC 69119 deponerade transfektomet, (ii) odlar nämnda värdcell i förhällanden där expressionen av nämnda chimära anti-CD20-antikropp ästadkoms, och (iii) isolerar den chimära anti-CD20-antikroppen 15 producerad av nämnda värdcell.
11. Förfarande enligt patentkrav 9, k ä n n e -20 tecknat av att det ytterligare innehäller ett steg väri den isolerade mus-antikropp stämplas med en radioaktiv stämpel.
12. Förfarande enligt patentkrav 11, k ä n n e - . tecknat av att nämnda radiostämpel är yttrium(90), ; 25 indium(lll) eller jod(131).
’ 13. Förfarande enligt patentkrav 12, k ä n n e - tecknat av att nämnda radiostämpel är yttrium(90).
14. Förfarande enligt nägot av patentkraven 9-12, kännetecknatav att nämnda hybridom är HB 11388. 30
15. Hybridom som utsöndrar en anti-CD20-antikropp och som har deponerats vid ATCC-depositionsinstitution med depositionsnummer HB 11388.
FI952327A 1992-11-13 1995-05-12 Förfarande för framställning av terapeutiska användbara immunologiskt aktiva, chimera antikroppar, vilka spesifikt binder CD20-antigenen FI112033B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US97889192A 1992-11-13 1992-11-13
US97889192 1992-11-13
US08/149,099 US5736137A (en) 1992-11-13 1993-11-03 Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US14909993 1993-11-03
US9310953 1993-11-12
PCT/US1993/010953 WO1994011026A2 (en) 1992-11-13 1993-11-12 Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma

Publications (3)

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FI952327A0 FI952327A0 (sv) 1995-05-12
FI952327A FI952327A (sv) 1995-07-10
FI112033B true FI112033B (sv) 2003-10-31

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US (8) US6399061B1 (sv)
EP (3) EP0752248B1 (sv)
JP (3) JP3095175B2 (sv)
AT (2) ATE139900T1 (sv)
AU (1) AU688743B2 (sv)
BG (1) BG62386B1 (sv)
CA (1) CA2149329C (sv)
DE (3) DE69329503T2 (sv)
DK (2) DK0669836T3 (sv)
ES (2) ES2091684T3 (sv)
FI (1) FI112033B (sv)
GR (2) GR3020731T3 (sv)
LU (1) LU91089I2 (sv)
LV (1) LV11732B (sv)
MD (1) MD1367C2 (sv)
NL (1) NL300156I2 (sv)
NO (4) NO321137B1 (sv)
NZ (1) NZ258392A (sv)
PL (2) PL174721B1 (sv)
PT (1) PT752248E (sv)
RO (1) RO118524B1 (sv)
RU (1) RU2139731C1 (sv)
WO (1) WO1994011026A2 (sv)

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