AR127343A1 - Construcciones de citoquinas activables triméricas y composiciones y métodos relacionados - Google Patents
Construcciones de citoquinas activables triméricas y composiciones y métodos relacionadosInfo
- Publication number
- AR127343A1 AR127343A1 ARP220102776A ARP220102776A AR127343A1 AR 127343 A1 AR127343 A1 AR 127343A1 AR P220102776 A ARP220102776 A AR P220102776A AR P220102776 A ARP220102776 A AR P220102776A AR 127343 A1 AR127343 A1 AR 127343A1
- Authority
- AR
- Argentina
- Prior art keywords
- residue
- smm3
- smm2
- smm1
- monomeric
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 5
- 108090000695 Cytokines Proteins 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title 1
- 101000838340 Homo sapiens tRNA-dihydrouridine(20) synthase [NAD(P)+]-like Proteins 0.000 abstract 3
- 101100219167 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) BUL1 gene Proteins 0.000 abstract 3
- 230000000873 masking effect Effects 0.000 abstract 3
- 102100028986 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like Human genes 0.000 abstract 3
- 230000004913 activation Effects 0.000 abstract 2
- 102000004083 Lymphotoxin-alpha Human genes 0.000 abstract 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 abstract 1
- 102000012220 Member 14 Tumor Necrosis Factor Receptors Human genes 0.000 abstract 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 239000013638 trimer Substances 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La presente invención provee construcciones de citoquinas activables que incluyen: una primera construcción monomérica que comprende una primera proteína citoquina (CP1), un primer resto escindible (CM1), y un primer resto de enmascaramiento estérico (SMM1), en donde el CM1 está ubicado entre la CP1 y el SMM1; una segunda construcción monomérica que comprende una segunda proteína citoquina (CP2), un segundo resto escindible (CM2), y un segundo resto de enmascaramiento estérico (SMM2), en donde el CM2 está ubicado entre la CP2 y el SMM2; y una tercera construcción monomérica que comprende una tercera proteína citoquina (CP3), un tercer resto escindible (CM3), y un tercer resto de enmascaramiento estérico (SMM3), en donde el CM3 está ubicado entre la CP3 y el SMM3, en donde: la CP2, la CP2 y la CP3 se unen entre sí, formando de este modo un trímero de la primera, la segunda y la tercera construcciones monoméricas; y el SMM1, el SMM2, y el SMM3 son moléculas globulares. Reivindicación 4: La ACC de la reivindicación 2, caracterizada porque la CP1, la CP2 y la CP3 son el miembro 14 de la superfamilia del factor de necrosis tumoral (TNFSF14). Reivindicación 45: La ACC de la reivindicación 41 o 42, caracterizada porque la actividad es la activación del mediador de entrada del virus del herpes y la activación del receptor b de linfotoxina. Reivindicación 63: El método de la reivindicación 62, caracterizado porque el sujeto ha sido identificado o diagnosticado como sujeto que tiene cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163255340P | 2021-10-13 | 2021-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR127343A1 true AR127343A1 (es) | 2024-01-31 |
Family
ID=84362661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220102776A AR127343A1 (es) | 2021-10-13 | 2022-10-12 | Construcciones de citoquinas activables triméricas y composiciones y métodos relacionados |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR127343A1 (es) |
TW (1) | TW202334186A (es) |
WO (1) | WO2023064791A1 (es) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0279862B1 (en) | 1986-08-28 | 1993-11-03 | Teijin Limited | Cytocidal antibody complex and process for its preparation |
ES2091684T3 (es) | 1992-11-13 | 1996-11-01 | Idec Pharma Corp | Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b. |
EP3492488A1 (en) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Activatable binding polypeptides and methods of identification and use thereof |
CA2753294A1 (en) | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Inc. | Proproteins and methods of use thereof |
CN113166220A (zh) * | 2018-03-09 | 2021-07-23 | 奥美药业有限公司 | 创新细胞因子前药 |
BR112020023118A2 (pt) * | 2018-05-14 | 2021-04-13 | Werewolf Therapeutics, Inc. | Polipeptídeos de interleucina 12 ativáveis e métodos de uso destes |
KR20210021467A (ko) * | 2018-05-14 | 2021-02-26 | 웨어울프 세라퓨틱스, 인크. | 활성화가능한 인터루킨-2 폴리펩타이드 및 이의 사용 방법 |
AU2020384375A1 (en) * | 2019-11-14 | 2022-05-26 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
-
2022
- 2022-10-12 TW TW111138606A patent/TW202334186A/zh unknown
- 2022-10-12 WO PCT/US2022/077943 patent/WO2023064791A1/en unknown
- 2022-10-12 AR ARP220102776A patent/AR127343A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2023064791A1 (en) | 2023-04-20 |
TW202334186A (zh) | 2023-09-01 |
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