CN101557818A - Atap肽、编码atap肽的核酸以及相关的应用方法 - Google Patents
Atap肽、编码atap肽的核酸以及相关的应用方法 Download PDFInfo
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- CN101557818A CN101557818A CNA2007800447140A CN200780044714A CN101557818A CN 101557818 A CN101557818 A CN 101557818A CN A2007800447140 A CNA2007800447140 A CN A2007800447140A CN 200780044714 A CN200780044714 A CN 200780044714A CN 101557818 A CN101557818 A CN 101557818A
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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Abstract
Description
引物 | 序列(5’至3’) |
TA-F(SEQ ID NO.10) | AACTCGAGCTAAGTTTGAACCTAAATCTGGCTGG |
TA-R(SEQ ID NO.11) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAG |
K1L-F(SEQ ID NO.12) | AACTCGAGCTCTGTTTGAACCTAAATCTGGCTGG |
K5L-F(SEQ ID NO.13) | AA-CTCGAGCTAAGTTTGAACCTCTATCTGGCTGGATGACTTTT |
K1,5L-F(SEQ ID NO.14) | AACTCGAGCTCTGTTTGAACCTCTATCTGGCTGGATGACTTTT |
K26L-R(SEQ ID NO.15) | TTGAATTCAACAGTATTGCAGCAGGAGAGATAGCATTTCAC |
引物 | 序列(5’至3’) |
sTA-F(SEQ ID NO.16) | ACTCGAGCTAAGTTTGAACCTAAATCTGGCTGGATGACTTTTCTAGAAGTTACAGGAAAGATCTGT |
sTA-R(SEQ ID NO.17) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAGCATTTCACAGATCTTTCCTGTAACTT |
E13Q-F(SEQ ID NO.18) | ACTCGAGCTAAGTTTGAACCTAAATCTGGCTGGATGACTTTTCTACAAGTTACAGGAAAGATCTGT |
E20Q-R(SEQ ID NO.19) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAGCATTTGACAGATCTTTCCTGTAACTT |
E13L-F(SEQ ID NO.20) | AACTCGAGCTAAGTTTGAACCTAAATCTGGCTGGATGACTTTTCTACTAGTTACAGGAAAGATCTGT |
E20L-R(SEQ ID NO.21) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAGCATTAGACAGATCTTTCCTGTAACTT |
E13K-F(SEQ ID NO.22) | AACTCGAGCTAAGTTTGAACCTAAATCTGGCTGGATGACTTTTCTAAAGGTTACAGGAAAGATCTGT |
E20K-R(SEQ ID NO.23) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAGCATCTTACAGATCTTTCCTGTAACTT |
K17L-F(SEQ ID NO.24) | AACTCGAGCTAAGTTTGAACCTAAATCTGGCTGGATGACTTTTCTAGAAGTTACAGGACTAATCTGT |
K17L-R(SEQ ID NO.25) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAGCATTTCACAGATTAGTCCTGTAACTT |
KE2L-F(SEQ ID NO.26) | AACTCGAGCTAAGTTTGAACCTAAATCTGGCTGGATGACTTTTCTACAAGTTACAGGACTAATCTGT |
KE2L-R(SEQ ID NO.27) | TTGAATTCAACAGTATTGCTTCAGGAGAGATAGCATTTGACAGATTAGTCCTGTAACTT |
TAxL-F(SEQ ID NO.28) | AACTCGAGCTGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTT |
TAxL-R(SEQ ID NO.29) | TTGAATTCATTTCCGACTGAAGAGTGAGCCCAGCAGAACCACGCCGGCCACAGT |
引物 | 序列(5’至3’) |
TAΔFR-1F(SEQ ID NO.30) | TCGAGGCTGGATGACTTTTCTAGAAGTTACAGGAAAGATCTGTGAAATGCTATCTCTCCTGAAGCAATG |
TAΔFR-1R(SEQ ID NO.31) | AATTCATTGCTTCAGGAGAGATAGCATTTCACAGATCTTTCCTGTAACTTCTAGAAAAGTCATCCAGCC |
引物 | 序列(5’至3’) |
接头-F(SEQ ID NO.32) | CCGGACTCCCCGCCCAGATCACCTTCCTGAGCGTGCCCGGCTC |
接头-R(SEQ ID NO.33) | TCGAGAGCCGGGCACGCTCAGGAAGGTGATCTGGGCGGGGAGT |
引物 | 序列(5’至3’) |
FLAG/FP4-F(SEQ IDNO.34) | CCGCTAGCGCTACCGGTCGCCACCATGGACTACAAAGACGATGACGACAAGCTTGAATTCGATTTTCCACCTCCC |
FLAG/FP4-R(SEQ ID NO.35) | AGCTCGAGATCTGAGTCCGGACTTGTAGCTGCCCAGTTCTTCATCGGTAGGGGGAGGTGGAAAATCGAATTCAA |
引物 | 序列(5’至3’) |
HCCS-mF(SEQ ID NO.55) | AACGTCTCAAGGAAAGATCTGTCAGATGCTCTTCTGTCCTGAAGCAATA |
HCCS-mR(SEQ ID NO.56) | AACGTCTCATCCTGTAACCTGTAGAAAAGTCATCCAGCCAGATTTA |
HCCS-anchor-F(SEQ ID NO.57) | AATCCGGAATGAGAGTTTCATTCTGTCGCCCAGG |
HCCS-anchor-R(SEQ ID NO.58) | AAGAATTCAAAAGTAGAAGTATGTGTTGGCAATCG |
Claims (29)
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CNA2007800447140A Pending CN101557818A (zh) | 2006-10-03 | 2007-10-03 | Atap肽、编码atap肽的核酸以及相关的应用方法 |
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US (1) | US9505821B2 (zh) |
EP (1) | EP2099467B1 (zh) |
KR (1) | KR101161923B1 (zh) |
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CN108181214A (zh) * | 2018-02-09 | 2018-06-19 | 北京爱泰浦生物医药科技有限责任公司 | 使用atap肽治疗疾病的方法和组合物 |
CN112867791A (zh) * | 2018-10-15 | 2021-05-28 | 苏黎世联邦理工学院 | 用于转导蛋白质-蛋白质相互作用的新方法 |
CN118184759A (zh) * | 2024-03-25 | 2024-06-14 | 北京爱泰浦生物医药科技有限责任公司 | Atap多肽及其疫苗的制备方法和应用 |
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CN107216368B (zh) * | 2016-03-21 | 2021-02-23 | 中国科学院苏州纳米技术与纳米仿生研究所 | 阳离子双亲性多肽及其应用 |
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CN108014325B (zh) * | 2018-02-09 | 2023-12-05 | 北京爱泰浦生物医药科技有限责任公司 | 多肽在治疗癌症中的应用 |
WO2021211098A1 (en) | 2020-04-14 | 2021-10-21 | Trim-Edicine, Inc. | Prevention and treatment of viral infection-induced organ failure |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108181214A (zh) * | 2018-02-09 | 2018-06-19 | 北京爱泰浦生物医药科技有限责任公司 | 使用atap肽治疗疾病的方法和组合物 |
CN112867791A (zh) * | 2018-10-15 | 2021-05-28 | 苏黎世联邦理工学院 | 用于转导蛋白质-蛋白质相互作用的新方法 |
CN118184759A (zh) * | 2024-03-25 | 2024-06-14 | 北京爱泰浦生物医药科技有限责任公司 | Atap多肽及其疫苗的制备方法和应用 |
Also Published As
Publication number | Publication date |
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EP2099467A2 (en) | 2009-09-16 |
KR101161923B1 (ko) | 2012-07-03 |
KR20090094806A (ko) | 2009-09-08 |
WO2008060776A2 (en) | 2008-05-22 |
WO2008060776A3 (en) | 2008-09-25 |
EP2099467B1 (en) | 2017-05-10 |
EP2099467A4 (en) | 2010-05-26 |
US9505821B2 (en) | 2016-11-29 |
US20100222263A1 (en) | 2010-09-02 |
CN105061580A (zh) | 2015-11-18 |
CN105061580B (zh) | 2020-06-05 |
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