BR112023002123A2 - Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo - Google Patents

Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo

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Publication number
BR112023002123A2
BR112023002123A2 BR112023002123A BR112023002123A BR112023002123A2 BR 112023002123 A2 BR112023002123 A2 BR 112023002123A2 BR 112023002123 A BR112023002123 A BR 112023002123A BR 112023002123 A BR112023002123 A BR 112023002123A BR 112023002123 A2 BR112023002123 A2 BR 112023002123A2
Authority
BR
Brazil
Prior art keywords
fusion protein
protein
effector
methods
fcrp
Prior art date
Application number
BR112023002123A
Other languages
English (en)
Inventor
Liu Yichin
Carine Moussion Christine
William Bainbridge Travis
Hosseini Iraj
Alan Lazar Gregory
Cohen Sivan
Charles Kemball Christopher
M Schartner Jill
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112023002123A2 publication Critical patent/BR112023002123A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

PROTEÍNA DE FUSÃO FC, ÁCIDOS NUCLEICOS ISOLADOS, MÉTODO DE PRODUÇÃO DA PROTEÍNA DE FUSÃO FC, FORMULAÇÃO FARMACÊUTICA, MÉTODOS PARA EXPANDIR O NÚMERO DE CÉLULAS DENDRÍTICAS (DCS) EM UM INDIVÍDUO E PARA TRATAR UM CÂNCER, PROTEÍNA FC SEM EFETORA E ANTICORPO. A invenção fornece uma proteína Fc sem efetora de imunoglobulina, fusões da proteína Fc sem efetora com um ligante Flt3 e métodos de uso da mesma.
BR112023002123A 2020-08-07 2021-08-05 Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo BR112023002123A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063062713P 2020-08-07 2020-08-07
PCT/US2021/044586 WO2022031876A1 (en) 2020-08-07 2021-08-05 Flt3 ligand fusion proteins and methods of use

Publications (1)

Publication Number Publication Date
BR112023002123A2 true BR112023002123A2 (pt) 2023-03-07

Family

ID=77519822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023002123A BR112023002123A2 (pt) 2020-08-07 2021-08-05 Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo

Country Status (17)

Country Link
US (2) US11542308B2 (pt)
EP (1) EP4192854A1 (pt)
JP (1) JP2023536655A (pt)
KR (1) KR20230042596A (pt)
CN (1) CN116234830A (pt)
AR (1) AR123158A1 (pt)
AU (1) AU2021322239A1 (pt)
BR (1) BR112023002123A2 (pt)
CA (1) CA3188426A1 (pt)
CL (1) CL2023000381A1 (pt)
CO (1) CO2023001488A2 (pt)
CR (1) CR20230119A (pt)
IL (1) IL300260A (pt)
MX (2) MX2023001441A (pt)
PE (1) PE20230983A1 (pt)
TW (1) TW202221016A (pt)
WO (1) WO2022031876A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220389394A1 (en) 2021-05-18 2022-12-08 Gilead Sciences, Inc. METHODS OF USING FLT3L-Fc FUSION PROTEINS
AU2022291381A1 (en) 2021-06-11 2023-11-30 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-cancer agents
KR20240019330A (ko) 2021-06-11 2024-02-14 길리애드 사이언시즈, 인코포레이티드 Mcl-1 저해제와 항체 약물 접합체의 조합
WO2023235886A2 (en) * 2022-06-03 2023-12-07 The University Of Chicago Antigen tolerance induction through use of flt3l variants

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Also Published As

Publication number Publication date
TW202221016A (zh) 2022-06-01
CL2023000381A1 (es) 2023-07-28
US11542308B2 (en) 2023-01-03
EP4192854A1 (en) 2023-06-14
MX2023001440A (es) 2023-03-06
MX2023001441A (es) 2023-03-06
JP2023536655A (ja) 2023-08-28
CA3188426A1 (en) 2022-02-10
AR123158A1 (es) 2022-11-02
WO2022031876A1 (en) 2022-02-10
US20220289803A1 (en) 2022-09-15
CN116234830A (zh) 2023-06-06
US20230279067A1 (en) 2023-09-07
KR20230042596A (ko) 2023-03-28
AU2021322239A1 (en) 2023-02-23
CO2023001488A2 (es) 2023-02-16
IL300260A (en) 2023-03-01
PE20230983A1 (es) 2023-06-21
CR20230119A (es) 2023-05-16

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