CY1114944T1 - Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων - Google Patents

Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων

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Publication number
CY1114944T1
CY1114944T1 CY20131101100T CY131101100T CY1114944T1 CY 1114944 T1 CY1114944 T1 CY 1114944T1 CY 20131101100 T CY20131101100 T CY 20131101100T CY 131101100 T CY131101100 T CY 131101100T CY 1114944 T1 CY1114944 T1 CY 1114944T1
Authority
CY
Cyprus
Prior art keywords
pepties
helicide
stabilized alpha
polypeptides
stabilized
Prior art date
Application number
CY20131101100T
Other languages
English (en)
Inventor
Loren D Walensky
Stanley J Korsmeyer
Gregory Verdine
Original Assignee
Dana-Farber Cancer Institute, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Dana-Farber Cancer Institute, Inc. filed Critical Dana-Farber Cancer Institute, Inc.
Publication of CY1114944T1 publication Critical patent/CY1114944T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

Abstract

Νέα πολυπεπτίδια και μέθοδοι παρασκευής και χρήσης τους περιγράφονται στο παρόν. Τα πολυπεπτίδια περιλαμβάνουν διασυνδετικά («συρραφής υδρογονανθράκων») τμήματα ώστε να παρέχουν έναν συνδετικό φορέα μεταξύ δύο τμημάτων αμινοξέων, ο οποίος περιορίζει τη δευτεροταγή δομή του πολυπεπτιδίου. Τα πολυπεπτίδια που περιγράφονται στο παρόν μπορεί να χρησιμοποιηθούν για αντιμετώπιση νόσων οι οποίες χαρακτηρίζονται από υπερβολικό ή ανεπαρκή κυτταρικό θάνατο.
CY20131101100T 2003-11-05 2013-12-04 Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων CY1114944T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51784803P 2003-11-05 2003-11-05
US59154804P 2004-07-27 2004-07-27
EP04811198.3A EP1680443B9 (en) 2003-11-05 2004-11-05 Stabilized alpha helical peptides and uses thereof

Publications (1)

Publication Number Publication Date
CY1114944T1 true CY1114944T1 (el) 2016-12-14

Family

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Country Status (17)

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US (6) US7723469B2 (el)
EP (4) EP2332967B1 (el)
JP (5) JP5122142B2 (el)
CN (3) CN103467588B (el)
AU (1) AU2004287884C1 (el)
BR (1) BRPI0416258A (el)
CA (2) CA2830063C (el)
CY (1) CY1114944T1 (el)
DK (2) DK1680443T5 (el)
ES (2) ES2437567T3 (el)
HK (1) HK1089191A1 (el)
IL (3) IL175152A (el)
PL (2) PL1680443T3 (el)
PT (2) PT1680443E (el)
SI (1) SI1680443T1 (el)
WO (1) WO2005044839A2 (el)
ZA (1) ZA200603565B (el)

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