DE60236953D1 - Effiziente hemmung des eintritts von hiv-1-virus durch ein neues fusionsprotein mit cd4 - Google Patents

Effiziente hemmung des eintritts von hiv-1-virus durch ein neues fusionsprotein mit cd4

Info

Publication number
DE60236953D1
DE60236953D1 DE60236953T DE60236953T DE60236953D1 DE 60236953 D1 DE60236953 D1 DE 60236953D1 DE 60236953 T DE60236953 T DE 60236953T DE 60236953 T DE60236953 T DE 60236953T DE 60236953 D1 DE60236953 D1 DE 60236953D1
Authority
DE
Germany
Prior art keywords
terminus
hiv
virus
initiation
fusion protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236953T
Other languages
English (en)
Inventor
James Arthos
Claudia Cicala
Anthony S Fauci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
US Government
Original Assignee
US Department of Health and Human Services
US Government
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, US Government filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE60236953D1 publication Critical patent/DE60236953D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60236953T 2001-10-25 2002-10-24 Effiziente hemmung des eintritts von hiv-1-virus durch ein neues fusionsprotein mit cd4 Expired - Lifetime DE60236953D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34623101P 2001-10-25 2001-10-25
PCT/US2002/034393 WO2003040311A2 (en) 2001-10-25 2002-10-24 Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4

Publications (1)

Publication Number Publication Date
DE60236953D1 true DE60236953D1 (de) 2010-08-19

Family

ID=23358507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60236953T Expired - Lifetime DE60236953D1 (de) 2001-10-25 2002-10-24 Effiziente hemmung des eintritts von hiv-1-virus durch ein neues fusionsprotein mit cd4

Country Status (6)

Country Link
US (2) US7368114B2 (de)
EP (1) EP1446158B1 (de)
AT (1) ATE473015T1 (de)
AU (1) AU2002363465A1 (de)
DE (1) DE60236953D1 (de)
WO (1) WO2003040311A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0922209D0 (en) * 2009-12-18 2010-02-03 Univ Nottingham Proteins, nucleic acid molecules and compositions
EP2706356A1 (de) * 2012-09-06 2014-03-12 Laboratorios Del. Dr. Esteve, S.A. Verfahren zur Identifizierung HIV-neutralisierender Antikörper
UY36990A (es) * 2015-11-21 2017-11-30 Fundació Privada Inst De Recerca De La Sida-Caixa (Irsicaixa) Derivados de anticuerpos contra el vih con actividad dual antiviral e inmunomodulatoria
WO2017123918A1 (en) 2016-01-15 2017-07-20 American Gene Technologies International Inc. Methods and compositons for the activation of gamma-delta t-cells
ES2911448T3 (es) 2016-03-09 2022-05-19 American Gene Tech Int Inc Vectores combinados y métodos para el tratamiento del cáncer
CA3028982A1 (en) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Hiv pre-immunization and immunotherapy
EP3876952A4 (de) 2018-11-05 2022-08-24 American Gene Technologies International Inc. Vektorsystem zur expression von regulatorischer rna
EP3880248A4 (de) * 2018-11-14 2022-08-10 JN Biosciences, LLC Multimere hybride fc-proteine zum ersatz von ivig
BR112022017678A2 (pt) * 2020-03-03 2022-11-08 American Gene Tech Int Inc Expressão sob demanda de fatores exógenos em linfócitos para tratar hiv
BR112023002123A2 (pt) 2020-08-07 2023-03-07 Genentech Inc Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo
CN116554356B (zh) * 2023-05-16 2024-01-23 武汉大学 一种hyperIL-15与sCD4及Fc的融合蛋白及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126433A (en) * 1986-08-21 1992-06-30 The Trustees Of Columbia University In The City Of New York Soluble forms of the t cell surface protein cd4
US5110906A (en) * 1986-08-21 1992-05-05 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
WO1992013559A1 (en) * 1991-02-08 1992-08-20 Progenics Pharmaceuticals, Inc. CD4-GAMMA1 AND CD4-IgG1 CHIMERAS
JP3670276B2 (ja) * 1991-02-08 2005-07-13 プロゲニクス・ファーマスーティカルズ、インコーポレイテッド ＣＤ４― ガンマ・２キメラ及びＣＤ４ ― ＩｇＧ２・キメラ
ATE170559T1 (de) 1991-05-31 1998-09-15 Genentech Inc Behandlung der hiv-assoziierten immun- thrombopenie purpura
JPH08503125A (ja) * 1992-08-07 1996-04-09 プロジェニクス・ファーマスーティカルス・インコーポレーテッド 非ペプチジル成分と複合化されたＣＤ４−ガンマ２およびＣＤ４−ＩｇＧ２免疫複合体、並びにその使用
US5817767A (en) * 1993-02-24 1998-10-06 Progenics Pharmaceuticals, Inc. Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same
WO1997047732A2 (en) * 1996-06-14 1997-12-18 Smithkline Beecham Corporation Hexameric fusion proteins and uses therefor
CA2361292C (en) 1999-03-16 2012-05-29 Edward A. Berger A novel chimeric protein for prevention and treatment of hiv infection
US6475749B1 (en) * 1999-08-11 2002-11-05 The Regents Of The University Of California Rh hybrid antibody

Also Published As

Publication number Publication date
WO2003040311A2 (en) 2003-05-15
EP1446158A4 (de) 2005-09-28
EP1446158A2 (de) 2004-08-18
US7368114B2 (en) 2008-05-06
US20040265306A1 (en) 2004-12-30
EP1446158B1 (de) 2010-07-07
ATE473015T1 (de) 2010-07-15
AU2002363465A1 (en) 2003-05-19
AU2002363465A8 (en) 2003-05-19
US20090285815A1 (en) 2009-11-19
WO2003040311A3 (en) 2003-10-16

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