HUP0001579A2 - Cell surface molecule mediating cell adhesion and signal transmission - Google Patents
Cell surface molecule mediating cell adhesion and signal transmissionInfo
- Publication number
- HUP0001579A2 HUP0001579A2 HU0001579A HUP0001579A HUP0001579A2 HU P0001579 A2 HUP0001579 A2 HU P0001579A2 HU 0001579 A HU0001579 A HU 0001579A HU P0001579 A HUP0001579 A HU P0001579A HU P0001579 A2 HUP0001579 A2 HU P0001579A2
- Authority
- HU
- Hungary
- Prior art keywords
- antibodies
- ferm
- recognising
- extracellular
- fragments
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 3
- 230000021164 cell adhesion Effects 0.000 title 1
- 230000008054 signal transmission Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000012634 fragment Substances 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 230000004927 fusion Effects 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- 239000003226 mitogen Substances 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 241001302160 Escherichia coli str. K-12 substr. DH10B Species 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 241000699660 Mus musculus Species 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000011813 knockout mouse model Methods 0.000 abstract 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000011830 transgenic mouse model Methods 0.000 abstract 1
Abstract
A cell surface polypeptide (I) which is expressed by thymocytes and by mitogen-stimulated lymphocytes, is new. It induces adhesion of mitogen-stimulated lymphocytes to antibodies recognising (I); these antibodies also produce an increase in peripheral blood lymphocytes in the presence of an antibody recognising CD3 antigen. (I) contains the amino acid sequence FDPPPF in its extracellular region and the sequence YMFM in its intracellular region. The polypeptide (I) is preferably of human origin. Also claimed are: (1) polypeptides derived from (I) by addition, deletion or substitution of one or more amino acid residues; (2) DNA coding for (I), its derivatives or its fragments; (3) vectors containing the DNA as in (2); (4) host cells transformed by the vectors as in (3) (especially where the transformant is Escherichia coli DH10B, FERM BP-5725); (5) disulphide-bond homodimers of extracellular fragments of (I); (6) fusion peptides containing (I) extracellular fragments together with a part of an immunoglobulin (especially IgG) (such as a n IgG heavy chain constant region or its hinge, C2 or C3 domain); (7) disulphide-bond homodimers of these fusion peptides; (8) antibodies (especially monoclonal antibodies) recognising all or part of (I); (9) hybridomas expressing antibodies as in (8)(especially FERM BP-5707 and FERM BP-5708); (10)transgenic mice expressing rat or human (I); and (11) knockout mice lacking the ability to express (I).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP96229097 | 1997-02-27 | ||
| JP06221798A JP3521382B2 (en) | 1997-02-27 | 1998-02-26 | Cell surface molecules that mediate cell-cell adhesion and signal transduction |
| PCT/JP1998/000837 WO1998038216A1 (en) | 1997-02-27 | 1998-02-27 | Cell surface molecule mediating cell adhesion and signal transmission |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001579A2 true HUP0001579A2 (en) | 2000-07-28 |
| HU227722B1 HU227722B1 (en) | 2012-01-30 |
Family
ID=13193772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001579A HU227722B1 (en) | 1997-02-27 | 1998-02-27 | Cell surface molecule mediating cell adhesion and signal transmission |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HU227722B1 (en) |
-
1998
- 1998-02-27 HU HU0001579A patent/HU227722B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU227722B1 (en) | 2012-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0606217T3 (en) | CTL4 receptor, fusion proteins containing it and its use | |
| WO2000023573A3 (en) | Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies | |
| PT1141274E (en) | BR43X2 SOLUVEL RECEIVER AND METHODS FOR THEIR USE | |
| WO1998050433A3 (en) | Human monoclonal antibodies to epidermal growth factor receptor | |
| IL108374A0 (en) | Methods and compositions for regulating the immune response using ctla4-binding molecules and il4-binding molecules | |
| AR052374A2 (en) | A COMPOSITION THAT INCLUDES AN OB VARIANT RECEIVER 12.1, A NUCLEIC ACID MOLECULA THAT CODIFIES SUCH OPERATIVELY LINKED RECEPTOR TO A PROMOTER, AN EXPRESSION VECTOR, A GUEST CELL, A FUSIONALLY ANNOUNCED UNIVERSITY FUNDING | |
| EP0784059A4 (en) | Antigenic polypeptide of chlamydia pneumoniae | |
| PT758394E (en) | Bifunctional protein prepares and uses | |
| MXPA02012106A (en) | B7-related nucleic acids and polypeptides useful for immunomodulation. | |
| ATE253593T1 (en) | IMMUNOGLOBULIN SUPERFAMILY DOMAINS AND FRAGMENTS WITH INCREASED SOLUBILITY | |
| WO2002099119A3 (en) | B7-related nucleic acids and polypeptides useful for immunomodulation | |
| AU6461294A (en) | Humanised antibodies | |
| Parkhouse | Three B-cell-surface molecules associating with membrane immunoglobulin | |
| WO1999046379A3 (en) | Human receptor proteins; related reagents and methods | |
| ES2129120T3 (en) | A RECEPTOR OF HUMAN T CELLS FROM THE FAMILY OF RECEPTORS COUPLED TO PROTEIN G. | |
| AU2002363465A1 (en) | Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4 | |
| HUP0001579A2 (en) | Cell surface molecule mediating cell adhesion and signal transmission | |
| CA2195653A1 (en) | Cells bearing cd4 decoy receptors and related molecules and methods | |
| Mageed | The RF antigen | |
| WO1996023884A3 (en) | Human peroxisome proliferator activated receptors | |
| WO1996021028A3 (en) | Soluble heterodimeric t cell receptors and their antibodies | |
| Gross et al. | Toxoplasma gondii: uptake of fetuin and identification of a 15-kDa fetuin-binding protein | |
| AU6310100A (en) | Single-chain polypeptides comprising troponin i n-terminal fragments and troponin | |
| Löster et al. | Analysis of protein aggregates by combination of cross-linking reactions and chromatographic separations | |
| CA2218755A1 (en) | Monoclonal antibody to human beta 2 integrin alpha subunit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |