SE9701127D0 - Antigenic fusionprotein carrying GALal, 3GAL epitopes - Google Patents

Antigenic fusionprotein carrying GALal, 3GAL epitopes

Info

Publication number
SE9701127D0
SE9701127D0 SE9701127A SE9701127A SE9701127D0 SE 9701127 D0 SE9701127 D0 SE 9701127D0 SE 9701127 A SE9701127 A SE 9701127A SE 9701127 A SE9701127 A SE 9701127A SE 9701127 D0 SE9701127 D0 SE 9701127D0
Authority
SE
Sweden
Prior art keywords
polypeptide
galal
fusion protein
plasma
blood
Prior art date
Application number
SE9701127A
Other languages
English (en)
Inventor
Jan Holgersson
Jining Liu
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE9701127A priority Critical patent/SE9701127D0/sv
Publication of SE9701127D0 publication Critical patent/SE9701127D0/sv
Priority to US09/194,396 priority patent/US6943239B2/en
Priority to AU67551/98A priority patent/AU751760B2/en
Priority to AT98912863T priority patent/ATE315047T1/de
Priority to PCT/SE1998/000555 priority patent/WO1998042750A1/en
Priority to DK98912863T priority patent/DK0923606T3/da
Priority to EP06075010A priority patent/EP1700868A3/en
Priority to ES98912863T priority patent/ES2258297T3/es
Priority to BR9804826-0A priority patent/BR9804826A/pt
Priority to EP98912863A priority patent/EP0923606B1/en
Priority to CA002255765A priority patent/CA2255765A1/en
Priority to JP54556998A priority patent/JP4099239B2/ja
Priority to DE69833106T priority patent/DE69833106T2/de
Priority to US11/153,082 priority patent/US20050255099A1/en
Priority to US12/507,626 priority patent/US20090286963A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
SE9701127A 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes SE9701127D0 (sv)

Priority Applications (15)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes
DE69833106T DE69833106T2 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal-epitope enthalten.
EP06075010A EP1700868A3 (en) 1997-03-26 1998-03-26 A method for removing an antibody from blood or plasma
BR9804826-0A BR9804826A (pt) 1997-03-26 1998-03-26 Proteìna de fusão antigênica portando epìtopos galoc 1,3 gal
AT98912863T ATE315047T1 (de) 1997-03-26 1998-03-26 Antigene fusionsproteine, die gal-alpha-1,3-gal- epitope enthalten.
PCT/SE1998/000555 WO1998042750A1 (en) 1997-03-26 1998-03-26 ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES
DK98912863T DK0923606T3 (da) 1997-03-26 1998-03-26 Antigent fusionsprotein med GALALPHA1,3GAL epitoper
US09/194,396 US6943239B2 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying Galα1,3Gal epitopes
ES98912863T ES2258297T3 (es) 1997-03-26 1998-03-26 Proteina de fusion antigenica portadora de epitopos gal-alfa-1,3gal.
AU67551/98A AU751760B2 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying galalpha1,3Gal epitopes
EP98912863A EP0923606B1 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying galalpha1,3gal epitopes
CA002255765A CA2255765A1 (en) 1997-03-26 1998-03-26 Antigenic fusionprotein carrying gal.alpha.1,3gal epitopes
JP54556998A JP4099239B2 (ja) 1997-03-26 1998-03-26 ＧＡＬα１、３ＧＡＬエピトープを有する抗原性融合タンパク質
US11/153,082 US20050255099A1 (en) 1997-03-26 2005-06-15 Antigenic fusion protein carrying Galalpha 1,3Gal epitopes
US12/507,626 US20090286963A1 (en) 1997-03-26 2009-07-22 Antigenic fusion protein carrying gal alpha1,3gal epitopes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Publications (1)

Publication Number Publication Date
SE9701127D0 true SE9701127D0 (sv) 1997-03-26

Family

ID=20406335

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9701127A SE9701127D0 (sv) 1997-03-26 1997-03-26 Antigenic fusionprotein carrying GALal, 3GAL epitopes

Country Status (12)

Country Link
US (3) US6943239B2 (sv)
EP (2) EP1700868A3 (sv)
JP (1) JP4099239B2 (sv)
AT (1) ATE315047T1 (sv)
AU (1) AU751760B2 (sv)
BR (1) BR9804826A (sv)
CA (1) CA2255765A1 (sv)
DE (1) DE69833106T2 (sv)
DK (1) DK0923606T3 (sv)
ES (1) ES2258297T3 (sv)
SE (1) SE9701127D0 (sv)
WO (1) WO1998042750A1 (sv)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002321760B9 (en) * 2001-07-20 2008-06-12 Absorber, Ab Blood group antigen fusion polypeptides and methods of use thereof
JP2005532793A (ja) * 2002-04-22 2005-11-04 レコファーマ アーベー 微生物付着を阻害するための融合ポリペプチドおよび方法
US8034351B2 (en) * 2002-04-22 2011-10-11 Recopharma Ab Mucin fusion polypeptide vaccines, compositions and methods of use thereof
CA2486106C (en) * 2002-05-16 2013-07-16 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
US20040096396A1 (en) * 2002-07-03 2004-05-20 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
NZ538629A (en) * 2002-08-09 2008-05-30 Recopharma Ab Mucin-immunoglobulin fusion proteins
US20050076759A1 (en) * 2003-10-08 2005-04-14 Brian Westfall Linear saw with stab-cut bevel capability
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US7459523B2 (en) * 2003-11-12 2008-12-02 Wisconsin Alumni Research Foundation Equine P-selectin glycoprotein ligand-1 and uses thereof
JP2007524658A (ja) * 2003-11-19 2007-08-30 グリコミメティクス， インコーポレイテッド Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
ATE383367T1 (de) * 2003-11-19 2008-01-15 Glycomimetics Inc Spezifischer antagonist sowohl für e- als auch p- selektine
WO2006001348A1 (ja) * 2004-06-23 2006-01-05 Japan Science And Technology Agency 浸潤抑制及び細胞殺傷剤
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
AU2006280101B2 (en) * 2005-08-09 2012-06-28 Glycomimetics, Inc. Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
CN101287741B (zh) 2005-09-02 2014-05-07 糖模拟物有限公司 异型双功能全选择素抑制剂
US20070113297A1 (en) * 2005-09-13 2007-05-17 Yongguang Yang Methods and compositions for inhibition of immune responses
WO2007132355A2 (en) * 2006-01-26 2007-11-22 Recopharma Ab Compositions and methods for inhibiting viral adhesion
US20070178447A1 (en) * 2006-01-31 2007-08-02 Bethyl Laboratories, Inc. Method for decreasing interference in results of immunochemical methods
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
JP5298020B2 (ja) 2006-10-12 2013-09-25 グリコミメティクス， インコーポレイテッド ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換
US7998486B2 (en) * 2006-10-25 2011-08-16 Newlink Genetics Corporation Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
CA2677747A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
ES2426784T3 (es) * 2008-06-13 2013-10-25 Glycomimetics, Inc. Tratamiento de cánceres de la sangre usando compuestos glicomiméticos seleccionados
AU2010241807B2 (en) 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
WO2012085165A1 (en) * 2010-12-21 2012-06-28 Recopharma Ab Tear substitutes
EP3296310A1 (en) 2011-12-22 2018-03-21 GlycoMimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
SI2928476T1 (en) 2012-12-07 2018-06-29 Glycomimetics, Inc. COMPONENTS, INSTALLATIONS AND PROCEDURES OF THE APPLICATION OF E-SELECTINE OF ANTAGONISTS FOR THE MOBILIZATION OF HEMATOPOETIC CELLS
AU2015355136B2 (en) 2014-12-03 2020-06-25 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
WO2018068010A1 (en) 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
BR112020013198A2 (pt) 2017-12-29 2020-12-01 Glycomimetics, Inc. inibidores heterobifuncionais de e-selectina e galectina-3
EP3761994A1 (en) 2018-03-05 2021-01-13 GlycoMimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2019241386A1 (en) * 2018-06-12 2019-12-19 Rush University Medical Center Methods for enhanced endothelialization of implanted material
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0606217T4 (da) * 1991-06-27 2009-03-30 Bristol Myers Squibb Co CTL4-receptor, fusionsproteiner indeholdende den samt anvendelse deraf
DK0666914T3 (da) * 1992-10-23 2004-04-13 Inst Genetics Llc Hidtil ukendt P-selectin-ligandprotein
US5821117A (en) 1993-03-16 1998-10-13 The Austin Research Institute Xenotransplantation therapies
GB9517758D0 (en) * 1995-08-31 1995-11-01 Imutran Ltd Compositions and their uses

Also Published As

Publication number Publication date
US20050255099A1 (en) 2005-11-17
ATE315047T1 (de) 2006-02-15
DE69833106D1 (de) 2006-03-30
EP1700868A3 (en) 2007-12-12
AU751760B2 (en) 2002-08-29
JP2000511782A (ja) 2000-09-12
AU6755198A (en) 1998-10-20
CA2255765A1 (en) 1998-10-01
US20090286963A1 (en) 2009-11-19
DE69833106T2 (de) 2006-08-31
US6943239B2 (en) 2005-09-13
EP0923606B1 (en) 2006-01-04
EP0923606A1 (en) 1999-06-23
JP4099239B2 (ja) 2008-06-11
US20020028205A1 (en) 2002-03-07
BR9804826A (pt) 2000-01-25
DK0923606T3 (da) 2006-05-22
WO1998042750A1 (en) 1998-10-01
ES2258297T3 (es) 2006-08-16
EP1700868A2 (en) 2006-09-13

Similar Documents

Publication Publication Date Title
SE9701127D0 (sv) Antigenic fusionprotein carrying GALal, 3GAL epitopes
ES2087323T3 (es) Metodo para producir peptidos exentos de cisteina.
KR910002897A (ko) 에리트로포이에틴(epo)펩타이드 및 이에 대한 항체
WO1999003987A3 (fr) Epitopes du vrs et anticorps les comportant, utiles dans le diagnostic et la therapie
BR9506059A (pt) Proteinas envelopes purificadas de virus c para uso de diagnóstico e terapêutico
ATE320448T1 (de) Gereinigte primate clta-8 antigene und verwandte reagenzien
KR960022559A (ko) 슈도모나스 에루지노사 막 단백질로부터 유도된 면역원성 하이브리드 단백질 OprF-Oprl
EP0699755A3 (en) Process for obtaining modified immunoglobulins with reduced immunogenicity of the variable domains of a murine antibody, compositions containing them
DE69328489D1 (de) Stress-proteine epitopen
ATE178092T1 (de) Methode zur selektion spezifischer bakteriophagen
DE69227041T2 (de) Expression und reinigung von rekombinantem, löslichem gewebefaktor
DE59208982D1 (de) Verfahren zur Reinigung von IgG-monoklonalen Antikörpern
DK0871474T3 (da) Generering af humant insulin
WO2003088995A3 (en) Mucin fusion polypeptide vaccines, compositions and methods of use thereof
WO2003003986A3 (en) Parathyroid hormone antibodies and related methods
DE60222759D1 (de) Proteinsyntheseverfahren mit zellfreiem proteinsynthesesystem
EP0722499A4 (en) IMMUNOREACTIVE ANTIGENS OF HEPATITIS E VIRUS
ES2179824T3 (es) Anticuerpos humanizados reactivos contra el antigeno gpiib/iiia.
AU2002363465A1 (en) Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4
AU2707992A (en) Monoclonal antibodies to hepatitis c virus
ATE207935T1 (de) Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
AU5398898A (en) Recombinant fusion proteins of the porcine reproductive and respiratory syndrome virus (PRRSV) and its use in diagnosis
ATE103973T1 (de) Gamma-atriales, natriuretisches polypeptid erkennende monoklonale antikoerper, solche antikoerper produzierende hybridome und deren herstellung und verwendung.
DK0476059T3 (da) Fremgangsmåder til forøgelse af modificeringshastigheden for metastabile bindinger
EP1734054A3 (en) Anti-human thymidylate synthase monoclonal antibody and hybridoma capable of producing the same