ATE383367T1 - Spezifischer antagonist sowohl für e- als auch p- selektine - Google Patents

Spezifischer antagonist sowohl für e- als auch p- selektine

Info

Publication number
ATE383367T1
ATE383367T1 AT04811491T AT04811491T ATE383367T1 AT E383367 T1 ATE383367 T1 AT E383367T1 AT 04811491 T AT04811491 T AT 04811491T AT 04811491 T AT04811491 T AT 04811491T AT E383367 T1 ATE383367 T1 AT E383367T1
Authority
AT
Austria
Prior art keywords
selectin
selectins
specific antagonist
modulators
mediated
Prior art date
Application number
AT04811491T
Other languages
English (en)
Inventor
John Magnani
John Patton
Original Assignee
Glycomimetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc filed Critical Glycomimetics Inc
Application granted granted Critical
Publication of ATE383367T1 publication Critical patent/ATE383367T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04811491T 2003-11-19 2004-11-18 Spezifischer antagonist sowohl für e- als auch p- selektine ATE383367T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52377503P 2003-11-19 2003-11-19
US58243504P 2004-06-24 2004-06-24

Publications (1)

Publication Number Publication Date
ATE383367T1 true ATE383367T1 (de) 2008-01-15

Family

ID=34636486

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04811491T ATE383367T1 (de) 2003-11-19 2004-11-18 Spezifischer antagonist sowohl für e- als auch p- selektine

Country Status (5)

Country Link
US (1) US7361644B2 (de)
EP (1) EP1763533B1 (de)
AT (1) ATE383367T1 (de)
DE (1) DE602004011272T2 (de)
WO (1) WO2005051920A2 (de)

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WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
WO2009152245A1 (en) * 2008-06-13 2009-12-17 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
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US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CA2858099C (en) 2011-12-22 2020-12-15 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
WO2014089269A1 (en) 2012-12-07 2014-06-12 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
CA2940579A1 (en) 2014-03-13 2015-09-17 Universitaet Basel Carbohydrate ligands that bind to igm antibodies against myelin-associated glycoprotein
WO2016089872A1 (en) 2014-12-03 2016-06-09 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
CN104803893A (zh) * 2015-03-12 2015-07-29 山东省鲁南煤化工工程技术研究院 一种制备4-氨基-2,7-萘二磺酸的方法
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AU2016323377B2 (en) 2015-09-16 2021-04-15 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (de) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Kombination von t-zell-checkpoint-inhibitoren mit e-selectin- oder cxcr4-inhibitoren oder mit heterobifunktionellen e-selectin- wie auch cxcr4-inhibitoren
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CN111566117A (zh) 2017-12-29 2020-08-21 糖模拟物有限公司 E-选择蛋白和半乳凝素-3的异双功能抑制剂
CN111867601A (zh) 2018-03-05 2020-10-30 糖模拟物有限公司 用于治疗急性髓系白血病及相关病症的方法
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3

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Also Published As

Publication number Publication date
DE602004011272D1 (de) 2008-02-21
US20050164982A1 (en) 2005-07-28
WO2005051920A3 (en) 2005-07-14
EP1763533B1 (de) 2008-01-09
US7361644B2 (en) 2008-04-22
EP1763533A2 (de) 2007-03-21
WO2005051920A2 (en) 2005-06-09
DE602004011272T2 (de) 2008-12-24

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