ATE357452T1 - Sialyl-lewisa und sialyl lewisx epitop-analoge - Google Patents

Sialyl-lewisa und sialyl lewisx epitop-analoge

Info

Publication number
ATE357452T1
ATE357452T1 AT97901546T AT97901546T ATE357452T1 AT E357452 T1 ATE357452 T1 AT E357452T1 AT 97901546 T AT97901546 T AT 97901546T AT 97901546 T AT97901546 T AT 97901546T AT E357452 T1 ATE357452 T1 AT E357452T1
Authority
AT
Austria
Prior art keywords
sialyl
lewisa
lewisx
epitop
analogue
Prior art date
Application number
AT97901546T
Other languages
English (en)
Inventor
Reinhold Oehrlein
Original Assignee
Glycomimetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc filed Critical Glycomimetics Inc
Application granted granted Critical
Publication of ATE357452T1 publication Critical patent/ATE357452T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97901546T 1996-01-30 1997-01-17 Sialyl-lewisa und sialyl lewisx epitop-analoge ATE357452T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH23096 1996-01-30

Publications (1)

Publication Number Publication Date
ATE357452T1 true ATE357452T1 (de) 2007-04-15

Family

ID=4182259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97901546T ATE357452T1 (de) 1996-01-30 1997-01-17 Sialyl-lewisa und sialyl lewisx epitop-analoge

Country Status (6)

Country Link
US (1) US6169077B1 (de)
EP (1) EP0886640B1 (de)
AT (1) ATE357452T1 (de)
AU (1) AU1542397A (de)
DE (1) DE69737496D1 (de)
WO (1) WO1997028173A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE287895T1 (de) * 1997-08-08 2005-02-15 Aventis Pharma Gmbh Substituierte tetrahydropyranderivate sowie verfahren zu deren herstellung
SE9904581D0 (sv) * 1999-12-15 1999-12-15 A & Science Invest Ab A novel helicobacter pylori-binding substance and use thereof
US7481790B2 (en) * 2000-12-27 2009-01-27 Advanced Cardiovascular Systems, Inc. Vessel enlargement by arteriogenic factor delivery
JP5183010B2 (ja) * 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
EP1539251A4 (de) * 2002-07-03 2009-02-25 Glycomimetics Inc Zusammensetzungen und verfahren zur diagnose und therapie von medizinischen erkrankungen mit angiogenese
CA2511174A1 (en) * 2002-12-20 2004-07-15 Glycomimetics, Inc. Oligosaccharides and conjugates thereof for the treatement of pseudomonas bacteria infection
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
JP2007524658A (ja) * 2003-11-19 2007-08-30 グリコミメティクス， インコーポレイテッド Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
ATE383367T1 (de) * 2003-11-19 2008-01-15 Glycomimetics Inc Spezifischer antagonist sowohl für e- als auch p- selektine
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
ES2375979T3 (es) 2005-08-09 2012-03-07 Glycomimetics, Inc. Inhibidores glicomiméticos de la lectina pa-il, lectina pa-iil o ambas lectinas de pseudomonas.
DK2264043T3 (da) 2005-09-02 2018-01-29 Glycomimetics Inc Heterobifunktionelle pan-selektin-inhibitorer
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
CA2666103C (en) 2006-10-12 2014-02-18 Glycomimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
CA2677747A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CN102088983B (zh) * 2008-06-13 2013-01-30 糖模拟物有限公司 利用选择的糖模拟化合物的血液癌症的治疗
JP5726171B2 (ja) * 2009-05-01 2015-05-27 グリコミメティックス インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
US9109002B2 (en) 2011-12-22 2015-08-18 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
GB201214736D0 (en) 2012-08-17 2012-10-03 Isis Innovation Inflammation imaging and therapy
LT2928476T (lt) 2012-12-07 2018-05-25 Glycomimetics, Inc. Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai
PL3227310T3 (pl) 2014-12-03 2020-02-28 Glycomimetics, Inc. Heterodwufunkcyjne inhibitory selektyn E i receptorów chemokinowych CXCR4”
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
JP2019524791A (ja) 2016-08-08 2019-09-05 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ
CN109890421B (zh) 2016-10-07 2023-10-20 糖模拟物有限公司 高效的多聚体e-选择蛋白拮抗剂
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (de) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunktionale inhibitoren von e-selektin und galectin-3
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
WO1994026760A1 (en) 1993-05-14 1994-11-24 Cytel Corporation SIALYL Lex ANALOGUES AS INHIBITORS OF CELLULAR ADHESION
SE9301677L (sv) 1993-05-14 1994-11-18 Kurt G I Nilsson Syntesmetod

Also Published As

Publication number Publication date
EP0886640A1 (de) 1998-12-30
AU1542397A (en) 1997-08-22
DE69737496D1 (de) 2007-05-03
EP0886640B1 (de) 2007-03-21
WO1997028173A1 (en) 1997-08-07
US6169077B1 (en) 2001-01-02

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties