ATE397005T1 - Sialyl-lewisa und sialyl-lewisx epitope analoge - Google Patents

Sialyl-lewisa und sialyl-lewisx epitope analoge

Info

Publication number
ATE397005T1
ATE397005T1 AT97901068T AT97901068T ATE397005T1 AT E397005 T1 ATE397005 T1 AT E397005T1 AT 97901068 T AT97901068 T AT 97901068T AT 97901068 T AT97901068 T AT 97901068T AT E397005 T1 ATE397005 T1 AT E397005T1
Authority
AT
Austria
Prior art keywords
sialyl
lewisa
lewisx
epitope analogue
epitope
Prior art date
Application number
AT97901068T
Other languages
English (en)
Inventor
Reinhold Oehrlein
Original Assignee
Glycomimetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc filed Critical Glycomimetics Inc
Application granted granted Critical
Publication of ATE397005T1 publication Critical patent/ATE397005T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97901068T 1996-01-30 1997-01-17 Sialyl-lewisa und sialyl-lewisx epitope analoge ATE397005T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH22996 1996-01-30

Publications (1)

Publication Number Publication Date
ATE397005T1 true ATE397005T1 (de) 2008-06-15

Family

ID=4182238

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97901068T ATE397005T1 (de) 1996-01-30 1997-01-17 Sialyl-lewisa und sialyl-lewisx epitope analoge

Country Status (6)

Country Link
US (1) US6187754B1 (de)
EP (1) EP0886639B1 (de)
AT (1) ATE397005T1 (de)
AU (1) AU1444697A (de)
DE (1) DE69738731D1 (de)
WO (1) WO1997028174A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9302982B2 (en) 2000-04-12 2016-04-05 Glycon Llc Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
US20060189547A1 (en) 2000-04-12 2006-08-24 Christian Samuel T Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use
US6548484B1 (en) * 2000-04-12 2003-04-15 International Medical Innovations, Inc. Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation
US7345031B2 (en) 2000-04-12 2008-03-18 International Medical Innovations, Inc. Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
FR2827599A1 (fr) * 2001-07-20 2003-01-24 Neuro3D Composes derives de quinoleine et quinoxaline,preparation et utilisations
FI20011664A (fi) * 2001-08-17 2003-02-18 Carbion Oy Syöpäpesifiset oligoskkaridisekvenssit ja niiden käyttö
JP5183010B2 (ja) 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
US20040096396A1 (en) * 2002-07-03 2004-05-20 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
JP2006515306A (ja) * 2002-12-20 2006-05-25 グリコミメティクス， インコーポレイテッド Ｐｓｅｕｄｏｍｏｎａｓ細菌感染の処置のためのオリゴ糖およびその結合体
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US7361644B2 (en) * 2003-11-19 2008-04-22 Glycomimetics, Inc. Specific antagonist for both E- and P-selectins
JP2007524658A (ja) * 2003-11-19 2007-08-30 グリコミメティクス， インコーポレイテッド Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
DK1928892T3 (da) * 2005-08-09 2012-01-30 Glycomimetics Inc Glycomimetiske inhibitorer af PA-IL-lectin PA-IIL-lectin eller begge lectiner fra pseudomonas
WO2007028050A1 (en) * 2005-09-02 2007-03-08 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
US7964569B2 (en) 2006-10-12 2011-06-21 Glycomimetics, Inc. Glycomimetic replacements for hexoses and N-acetyl hexosamines
AU2008216794A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CA2727788A1 (en) * 2008-06-13 2009-12-17 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
CN102421441B (zh) * 2009-05-01 2015-04-01 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双功能抑制剂
US8343971B2 (en) * 2009-09-15 2013-01-01 Rutgers, The State University Of New Jersey Pharmacologically-active vanilloid carbamates
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
CN104039805B (zh) 2011-12-22 2016-11-16 糖模拟物有限公司 E-选择蛋白拮抗剂化合物、组合物及使用方法
GB201214736D0 (en) 2012-08-17 2012-10-03 Isis Innovation Inflammation imaging and therapy
EP2928476B1 (de) 2012-12-07 2018-02-14 GlycoMimetics, Inc. Verbindungen, zusammensetzungen und verfahren mit e-selectin-antagonisten zur mobilisierung blutbildender zellen
WO2016089872A1 (en) 2014-12-03 2016-06-09 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
CA3009836A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (de) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunktionale inhibitoren von e-selektin und galectin-3
JP7455064B2 (ja) 2018-03-05 2024-03-25 グリコミメティクス， インコーポレイテッド 急性骨髄性白血病および関連状態を処置する方法
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
JPH08510729A (ja) * 1993-05-14 1996-11-12 サイテル コーポレイション 細胞接着のインヒビターとしてのシアリルＬｅ▲上ｘ▼類似体
SE9301677L (sv) * 1993-05-14 1994-11-18 Kurt G I Nilsson Syntesmetod

Also Published As

Publication number Publication date
AU1444697A (en) 1997-08-22
EP0886639A1 (de) 1998-12-30
EP0886639B1 (de) 2008-05-28
US6187754B1 (en) 2001-02-13
DE69738731D1 (de) 2008-07-10
WO1997028174A1 (en) 1997-08-07

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