ATE397005T1 - Sialyl-lewisa und sialyl-lewisx epitope analoge - Google Patents
Sialyl-lewisa und sialyl-lewisx epitope analogeInfo
- Publication number
- ATE397005T1 ATE397005T1 AT97901068T AT97901068T ATE397005T1 AT E397005 T1 ATE397005 T1 AT E397005T1 AT 97901068 T AT97901068 T AT 97901068T AT 97901068 T AT97901068 T AT 97901068T AT E397005 T1 ATE397005 T1 AT E397005T1
- Authority
- AT
- Austria
- Prior art keywords
- sialyl
- lewisa
- lewisx
- epitope analogue
- epitope
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH22996 | 1996-01-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE397005T1 true ATE397005T1 (de) | 2008-06-15 |
Family
ID=4182238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97901068T ATE397005T1 (de) | 1996-01-30 | 1997-01-17 | Sialyl-lewisa und sialyl-lewisx epitope analoge |
Country Status (6)
Country | Link |
---|---|
US (1) | US6187754B1 (de) |
EP (1) | EP0886639B1 (de) |
AT (1) | ATE397005T1 (de) |
AU (1) | AU1444697A (de) |
DE (1) | DE69738731D1 (de) |
WO (1) | WO1997028174A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9302982B2 (en) | 2000-04-12 | 2016-04-05 | Glycon Llc | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use |
US20060189547A1 (en) | 2000-04-12 | 2006-08-24 | Christian Samuel T | Novel pharmaceutical agents containing carbohydrate moieties and methods of their preparation and use |
US6548484B1 (en) * | 2000-04-12 | 2003-04-15 | International Medical Innovations, Inc. | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation |
US7345031B2 (en) | 2000-04-12 | 2008-03-18 | International Medical Innovations, Inc. | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use |
FR2827599A1 (fr) * | 2001-07-20 | 2003-01-24 | Neuro3D | Composes derives de quinoleine et quinoxaline,preparation et utilisations |
FI20011664A (fi) * | 2001-08-17 | 2003-02-18 | Carbion Oy | Syöpäpesifiset oligoskkaridisekvenssit ja niiden käyttö |
JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス, インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
US20040096396A1 (en) * | 2002-07-03 | 2004-05-20 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
JP2006515306A (ja) * | 2002-12-20 | 2006-05-25 | グリコミメティクス, インコーポレイテッド | Pseudomonas細菌感染の処置のためのオリゴ糖およびその結合体 |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
US7361644B2 (en) * | 2003-11-19 | 2008-04-22 | Glycomimetics, Inc. | Specific antagonist for both E- and P-selectins |
JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス, インコーポレイテッド | E−およびp−セレクチンの両方のための糖模倣物アンタゴニスト |
US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
DK1928892T3 (da) * | 2005-08-09 | 2012-01-30 | Glycomimetics Inc | Glycomimetiske inhibitorer af PA-IL-lectin PA-IIL-lectin eller begge lectiner fra pseudomonas |
WO2007028050A1 (en) * | 2005-09-02 | 2007-03-08 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
US20090176717A1 (en) * | 2006-06-01 | 2009-07-09 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
US7964569B2 (en) | 2006-10-12 | 2011-06-21 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and N-acetyl hexosamines |
AU2008216794A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and N-acetyl hexosamines |
US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
CA2727788A1 (en) * | 2008-06-13 | 2009-12-17 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
CN102421441B (zh) * | 2009-05-01 | 2015-04-01 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双功能抑制剂 |
US8343971B2 (en) * | 2009-09-15 | 2013-01-01 | Rutgers, The State University Of New Jersey | Pharmacologically-active vanilloid carbamates |
WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
CN104039805B (zh) | 2011-12-22 | 2016-11-16 | 糖模拟物有限公司 | E-选择蛋白拮抗剂化合物、组合物及使用方法 |
GB201214736D0 (en) | 2012-08-17 | 2012-10-03 | Isis Innovation | Inflammation imaging and therapy |
EP2928476B1 (de) | 2012-12-07 | 2018-02-14 | GlycoMimetics, Inc. | Verbindungen, zusammensetzungen und verfahren mit e-selectin-antagonisten zur mobilisierung blutbildender zellen |
WO2016089872A1 (en) | 2014-12-03 | 2016-06-09 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
CA3009836A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
BR112019006642A2 (pt) | 2016-10-07 | 2019-07-02 | Glycomimetics Inc | antagonistas multiméricos de e-selectina altamente potentes |
CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
EP3732186A1 (de) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Heterobifunktionale inhibitoren von e-selektin und galectin-3 |
JP7455064B2 (ja) | 2018-03-05 | 2024-03-25 | グリコミメティクス, インコーポレイテッド | 急性骨髄性白血病および関連状態を処置する方法 |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
JPH08510729A (ja) * | 1993-05-14 | 1996-11-12 | サイテル コーポレイション | 細胞接着のインヒビターとしてのシアリルLe▲上x▼類似体 |
SE9301677L (sv) * | 1993-05-14 | 1994-11-18 | Kurt G I Nilsson | Syntesmetod |
-
1997
- 1997-01-17 AT AT97901068T patent/ATE397005T1/de not_active IP Right Cessation
- 1997-01-17 AU AU14446/97A patent/AU1444697A/en not_active Abandoned
- 1997-01-17 EP EP97901068A patent/EP0886639B1/de not_active Expired - Lifetime
- 1997-01-17 DE DE69738731T patent/DE69738731D1/de not_active Expired - Lifetime
- 1997-01-17 US US09/117,521 patent/US6187754B1/en not_active Expired - Lifetime
- 1997-01-17 WO PCT/EP1997/000223 patent/WO1997028174A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU1444697A (en) | 1997-08-22 |
EP0886639A1 (de) | 1998-12-30 |
EP0886639B1 (de) | 2008-05-28 |
US6187754B1 (en) | 2001-02-13 |
DE69738731D1 (de) | 2008-07-10 |
WO1997028174A1 (en) | 1997-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |