ATE419268T1 - Haemasterlin analoge - Google Patents
Haemasterlin analogeInfo
- Publication number
- ATE419268T1 ATE419268T1 AT98962157T AT98962157T ATE419268T1 AT E419268 T1 ATE419268 T1 AT E419268T1 AT 98962157 T AT98962157 T AT 98962157T AT 98962157 T AT98962157 T AT 98962157T AT E419268 T1 ATE419268 T1 AT E419268T1
- Authority
- AT
- Austria
- Prior art keywords
- haemasterlin
- analogue
- analogs
- hemiasterlin
- synthesis
- Prior art date
Links
- KQODQNJLJQHFQV-UHFFFAOYSA-N (-)-hemiasterlin Natural products C1=CC=C2C(C(C)(C)C(C(=O)NC(C(=O)N(C)C(C=C(C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-UHFFFAOYSA-N 0.000 abstract 1
- KQODQNJLJQHFQV-MKWZWQCGSA-N (e,4s)-4-[[(2s)-3,3-dimethyl-2-[[(2s)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid Chemical compound C1=CC=C2C(C(C)(C)[C@@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)NC)=CN(C)C2=C1 KQODQNJLJQHFQV-MKWZWQCGSA-N 0.000 abstract 1
- 239000003080 antimitotic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 229930187626 hemiasterlin Natural products 0.000 abstract 1
- 108010057806 hemiasterlin Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Junction Field-Effect Transistors (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Amplifiers (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002225325A CA2225325A1 (en) | 1997-12-19 | 1997-12-19 | Hemiasterlin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419268T1 true ATE419268T1 (de) | 2009-01-15 |
Family
ID=4161925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98962157T ATE419268T1 (de) | 1997-12-19 | 1998-12-18 | Haemasterlin analoge |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7579323B1 (de) |
| EP (1) | EP1040119B1 (de) |
| JP (1) | JP4417551B2 (de) |
| KR (1) | KR100937756B1 (de) |
| CN (1) | CN100422208C (de) |
| AT (1) | ATE419268T1 (de) |
| AU (1) | AU762691C (de) |
| BR (1) | BR9813817A (de) |
| CA (2) | CA2225325A1 (de) |
| DE (1) | DE69840415D1 (de) |
| DK (1) | DK1040119T3 (de) |
| ES (1) | ES2320499T3 (de) |
| HU (1) | HUP0105460A3 (de) |
| IL (1) | IL136654A0 (de) |
| NZ (1) | NZ505086A (de) |
| WO (1) | WO1999032509A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1531846A4 (de) * | 2002-02-27 | 2006-04-19 | Us Gov Health & Human Serv | Konjugate aus ligand, linker und zytotoxischem agens sowie verwandte zusammensetzungen und verwendungsverfahren |
| US7192972B2 (en) | 2002-03-22 | 2007-03-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| US7064211B2 (en) * | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| US20040121965A1 (en) * | 2002-09-20 | 2004-06-24 | Wyeth Holdings Corporation | Method of treating resistant tumors |
| CN1705639A (zh) * | 2002-09-20 | 2005-12-07 | 惠氏控股公司 | 用于合成微管蛋白抑制剂的中间体的合成方法 |
| AU2003295808A1 (en) * | 2002-11-21 | 2004-06-18 | Wyeth | Hemiasterlin affinity probes and their uses |
| US7390910B2 (en) * | 2003-08-08 | 2008-06-24 | Wyeth | Compounds for treating tumors |
| GB201001070D0 (en) | 2010-01-22 | 2010-03-10 | St George's Hospital Medical School | Theraputic compounds and their use |
| AU2014228489B2 (en) | 2013-03-15 | 2018-11-15 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| DK3086815T3 (da) | 2013-12-27 | 2022-05-23 | Zymeworks Inc | Sulfonamidholdige forbindelsessystemer til lægemiddelkonjugater |
| KR20160125361A (ko) * | 2013-12-27 | 2016-10-31 | 자임워크스 인코포레이티드 | Ｖａｒ２ｃｓａ－약물 접합체 |
| RU2723651C2 (ru) | 2014-09-17 | 2020-06-17 | Займворкс Инк. | Цитотоксические и антимитотические соединения и способы их применения |
| CN114716506A (zh) | 2015-01-30 | 2022-07-08 | 苏特罗生物制药公司 | 用于偶联和治疗的哈米特林（hemiasterlin）衍生物 |
| LT3464336T (lt) | 2016-06-01 | 2022-05-10 | Athira Pharma, Inc. | Junginiai |
| US10517958B2 (en) | 2016-10-04 | 2019-12-31 | Zymeworks Inc. | Compositions and methods for the treatment of platinum-drug resistant cancer |
| US11179441B2 (en) | 2017-01-06 | 2021-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
| JP7202301B2 (ja) | 2017-08-10 | 2023-01-11 | 住友ファーマ株式会社 | ヘミアスタリン誘導体及びこれらの抗体薬物複合体 |
| PT3666787T (pt) | 2017-08-10 | 2024-03-21 | Sumitomo Pharma Co Ltd | Conjugados anticorpo-fármaco que incluem um derivado da hemiasterlina |
| US12178879B2 (en) | 2019-02-13 | 2024-12-31 | Sumitomo Pharma Co., Ltd. | Hemiasterlin derivative and antibody-drug conjugate thereof |
| WO2020166600A1 (ja) | 2019-02-13 | 2020-08-20 | 大日本住友製薬株式会社 | システイン残基を有するヘミアスタリン誘導体 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1049404B (it) | 1975-04-09 | 1981-01-20 | Zambeletti Spa L | Tripeptidi loro esteri ed amidi ad attivita antiulcera |
| EP0150227A1 (de) | 1983-12-23 | 1985-08-07 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Dipeptidderivate und ihre Verwendung für die Bestimmung der Aktivität von Carboxypeptidasen |
| IT1209644B (it) * | 1985-06-21 | 1989-08-30 | Isf Spa | Composti farmacologicamente attivi. |
| US4820691A (en) | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
| CA2042027A1 (en) | 1989-09-15 | 1991-03-16 | Arthur E. Bogden | Treatment of colon cancer |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| US5811515A (en) * | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| US5661175A (en) | 1995-06-20 | 1997-08-26 | Kashman; Yoel | Hemiasterlin and geodiamolide TA |
| EP0839155B1 (de) * | 1995-07-17 | 2004-10-13 | Medivir UK Ltd | CYSTEIN-PROTEASE-INHIBITOREN FÜR DIE BEHANDLUNG VON ALLERGISCHENKRANKHEITEN VERURSACHT DURCH IgE |
| US6214799B1 (en) * | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6194578B1 (en) | 1998-11-20 | 2001-02-27 | Pfizer Inc. | Dipeptide derivatives |
-
1997
- 1997-12-19 CA CA002225325A patent/CA2225325A1/en not_active Abandoned
-
1998
- 1998-12-13 US US09/581,511 patent/US7579323B1/en not_active Expired - Fee Related
- 1998-12-18 AU AU17459/99A patent/AU762691C/en not_active Ceased
- 1998-12-18 WO PCT/CA1998/001184 patent/WO1999032509A2/en not_active Ceased
- 1998-12-18 BR BR9813817-0A patent/BR9813817A/pt not_active Application Discontinuation
- 1998-12-18 HU HU0105460A patent/HUP0105460A3/hu unknown
- 1998-12-18 JP JP2000525446A patent/JP4417551B2/ja not_active Expired - Fee Related
- 1998-12-18 NZ NZ505086A patent/NZ505086A/en unknown
- 1998-12-18 AT AT98962157T patent/ATE419268T1/de not_active IP Right Cessation
- 1998-12-18 KR KR1020007006814A patent/KR100937756B1/ko not_active Expired - Fee Related
- 1998-12-18 CN CNB988124343A patent/CN100422208C/zh not_active Expired - Fee Related
- 1998-12-18 IL IL13665498A patent/IL136654A0/xx unknown
- 1998-12-18 ES ES98962157T patent/ES2320499T3/es not_active Expired - Lifetime
- 1998-12-18 DE DE69840415T patent/DE69840415D1/de not_active Expired - Lifetime
- 1998-12-18 EP EP98962157A patent/EP1040119B1/de not_active Expired - Lifetime
- 1998-12-18 DK DK98962157T patent/DK1040119T3/da active
- 1998-12-18 CA CA2312826A patent/CA2312826C/en not_active Expired - Fee Related
-
2009
- 2009-06-25 US US12/491,839 patent/US20090264487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1040119A2 (de) | 2000-10-04 |
| HUP0105460A2 (en) | 2002-06-29 |
| IL136654A0 (en) | 2001-06-14 |
| HUP0105460A3 (en) | 2002-08-28 |
| CN1282336A (zh) | 2001-01-31 |
| NZ505086A (en) | 2003-05-30 |
| AU1745999A (en) | 1999-07-12 |
| US20090264487A1 (en) | 2009-10-22 |
| DE69840415D1 (de) | 2009-02-12 |
| CA2225325A1 (en) | 1999-06-19 |
| WO1999032509A3 (en) | 1999-10-07 |
| HK1034523A1 (zh) | 2001-10-26 |
| KR100937756B1 (ko) | 2010-01-20 |
| AU762691B2 (en) | 2003-07-03 |
| ES2320499T3 (es) | 2009-05-22 |
| CA2312826C (en) | 2013-06-11 |
| US7579323B1 (en) | 2009-08-25 |
| WO1999032509A2 (en) | 1999-07-01 |
| KR20010024783A (ko) | 2001-03-26 |
| AU762691C (en) | 2004-07-08 |
| EP1040119B1 (de) | 2008-12-31 |
| BR9813817A (pt) | 2000-10-10 |
| CN100422208C (zh) | 2008-10-01 |
| JP4417551B2 (ja) | 2010-02-17 |
| DK1040119T3 (da) | 2009-04-14 |
| CA2312826A1 (en) | 1999-07-01 |
| JP2001526294A (ja) | 2001-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |