PT797439E - Utilizacao de pramipexote como agente neuroprotector - Google Patents
Utilizacao de pramipexote como agente neuroprotectorInfo
- Publication number
- PT797439E PT797439E PT95942961T PT95942961T PT797439E PT 797439 E PT797439 E PT 797439E PT 95942961 T PT95942961 T PT 95942961T PT 95942961 T PT95942961 T PT 95942961T PT 797439 E PT797439 E PT 797439E
- Authority
- PT
- Portugal
- Prior art keywords
- agent
- pramipexote
- neuroprotector
- pramipexole
- provides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Semiconductor Memories (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/357,121 US5650420A (en) | 1994-12-15 | 1994-12-15 | Pramipexole as a neuroprotective agent |
Publications (1)
Publication Number | Publication Date |
---|---|
PT797439E true PT797439E (pt) | 2003-08-29 |
Family
ID=23404382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT95942961T PT797439E (pt) | 1994-12-15 | 1995-12-12 | Utilizacao de pramipexote como agente neuroprotector |
Country Status (16)
Country | Link |
---|---|
US (1) | US5650420A (pt) |
EP (1) | EP0797439B1 (pt) |
JP (2) | JP4796219B2 (pt) |
KR (2) | KR100451874B1 (pt) |
CN (1) | CN1177586C (pt) |
AT (1) | ATE238790T1 (pt) |
AU (1) | AU712666B2 (pt) |
CA (1) | CA2207323C (pt) |
DE (1) | DE69530606T2 (pt) |
DK (1) | DK0797439T3 (pt) |
ES (1) | ES2197213T3 (pt) |
MX (1) | MX9704377A (pt) |
NZ (1) | NZ298606A (pt) |
PT (1) | PT797439E (pt) |
SI (1) | SI0797439T1 (pt) |
WO (1) | WO1996018395A1 (pt) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6156777A (en) * | 1994-12-15 | 2000-12-05 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
US6001861A (en) | 1998-01-16 | 1999-12-14 | Pharmacia & Upjohn Company | Use of pramipexole in the treatment of restless legs syndrome |
DE19701619B4 (de) * | 1997-01-17 | 2007-10-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von Pramipexol zur Behandlung des restless legs syndroms |
EP1591119A3 (en) * | 1998-05-15 | 2007-03-28 | Pharmacia & Upjohn Company LLC | Pramipexole for treating CNS diseases, especially Parkinson's disease |
WO1999059563A2 (en) * | 1998-05-15 | 1999-11-25 | Pharmacia & Upjohn Company | Cabergoline and pramipexole for treating cns diseases, especially parkinson's disease |
US6750235B1 (en) | 1999-09-30 | 2004-06-15 | The General Hospital Corporation | Pramipexole as a treatment for cocaine craving |
PE20011074A1 (es) | 2000-02-23 | 2001-10-04 | Upjohn Co | Uso de pramipexol en el tratamiento de trastornos de adiccion |
DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
DE10066158B4 (de) * | 2000-08-24 | 2007-08-09 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms |
US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
WO2002017931A1 (fr) * | 2000-09-01 | 2002-03-07 | Xiaomin Wang | Utilisation d'un ou de plusieurs extraits de tripterygium wilfordii hook.f pour la preparation de medicaments destines a prevenir et a traiter des troubles du systeme nerveux |
DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
WO2002069974A1 (en) * | 2001-03-05 | 2002-09-12 | Andrew Holman | Administration of sleep restorative agents |
FR2825087B1 (fr) * | 2001-05-22 | 2005-01-14 | Galderma Res & Dev | Analogues de la vitamine d |
DE10137453A1 (de) * | 2001-08-02 | 2003-02-20 | Boehringer Ingelheim Pharma | Pramlpexol als Antikonvulsivum |
DE10138275A1 (de) * | 2001-08-10 | 2003-02-27 | Boehringer Ingelheim Pharma | Verbindungen zur Beseitigung der Anhedonie |
US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
ES2351303T3 (es) * | 2001-12-11 | 2011-02-02 | University Of Virginia Patent Foundation | Utilización de pramipexol para el tratamiento de la esclerosis lateral amiotrófica. |
DE10203103A1 (de) * | 2002-01-25 | 2003-08-07 | Boehringer Ingelheim Pharma | Pramipexol zur Behandlung von HIV Demenz |
US20030166696A1 (en) * | 2002-01-24 | 2003-09-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pramipexole for the treatment of HIV dementia |
PA8578501A1 (es) | 2002-07-25 | 2005-02-04 | Pharmacia Corp | Forma de dosificacion una vez al dia de pramipexol |
GB0221513D0 (en) | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
DE10333393A1 (de) * | 2003-07-23 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit dem Wirkstoff Pramipexol |
CA2554616A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
WO2006012277A2 (en) * | 2004-06-30 | 2006-02-02 | Amr Technology, Inc. | Biocatalytic process for preparing enantiomerically enriched pramipexole |
CN101843597A (zh) | 2004-08-13 | 2010-09-29 | 贝林格尔·英格海姆国际有限公司 | 包含普拉克索或其可药用盐的延长释放小球制剂、其制备方法及其用途 |
JP2009504748A (ja) * | 2005-08-15 | 2009-02-05 | ユニバーシティ オブ バージニア パテント ファウンデーション | R(+)プラミペキソールを用いた神経回復 |
JP2009511618A (ja) * | 2005-10-18 | 2009-03-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中度から重度のむずむず脚症候群(rls)を治療するためのプラミペキソールの使用 |
ITMI20060044A1 (it) * | 2006-01-13 | 2007-07-14 | Dipharma Spa | Sintesi di intermedi pr la preparazione di pramipexolo |
WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
JP2009537565A (ja) | 2006-05-16 | 2009-10-29 | ノップ ニューロサイエンシーズ、インク. | R(+)およびs(−)プラミペキソール組成とそれを利用する方法 |
WO2008052953A1 (en) * | 2006-10-30 | 2008-05-08 | Boehringer Ingelheim International Gmbh | The use of pramipexole or a salt thereof for the treatment of parkinson's disease |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
ES2611314T3 (es) * | 2006-12-14 | 2017-05-08 | Knopp Biosciences Llc | Composiciones y procedimientos para usar (R)-pramipexol |
RU2454409C2 (ru) | 2007-03-14 | 2012-06-27 | Нопп Ньюросайенсиз, Инк. | Синтез хирально очищенных замещенных бензотиазолдиаминов |
WO2010022140A1 (en) | 2008-08-19 | 2010-02-25 | Knopp Neurosciences, Inc. | Compositions and methods of using (r)-pramipexole |
EP2442655A4 (en) * | 2009-06-19 | 2013-04-03 | Knopp Neurosciences Inc | COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
CA2918035C (en) | 2013-07-12 | 2023-01-03 | Knopp Biosciences Llc | Use of dexpramipexole in the treatment of disorders associated with elevated levels of eosinophils and/or basophils |
AU2014306683B2 (en) | 2013-08-13 | 2017-10-12 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
PT3033081T (pt) | 2013-08-13 | 2021-06-01 | Knopp Biosciences Llc | Composições e métodos para o tratamento da urticária crónica |
WO2016194015A2 (en) | 2015-06-04 | 2016-12-08 | Chiarugi Alberto | Use of r(+)-pramipexole (dexpramipexole) for the treatment of cerebral ischemia of the focal type |
US10799484B2 (en) | 2017-03-27 | 2020-10-13 | Chase Therapeutics Corporation | Compositions and methods for treating synucleinopathies |
CN111918649B (zh) | 2018-03-16 | 2024-07-30 | 脑科学香料株式会社 | 缺氧障碍、缺血再灌注障碍或炎症的预防或治疗剂,移植用细胞保护剂,及生物体防腐剂 |
BR112021012491A2 (pt) * | 2018-12-27 | 2021-09-08 | Chase Therapeutics Corporation | Combinações antineurodegenerativas de domperidona e uso |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3447075A1 (de) * | 1984-12-22 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
ATE45735T1 (de) * | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
DE3843227A1 (de) * | 1988-12-22 | 1990-07-05 | Boehringer Ingelheim Kg | Neue verwendung von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzthiazol |
DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
DE4241013A1 (de) * | 1992-12-05 | 1994-06-09 | Boehringer Ingelheim Kg | Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung |
-
1994
- 1994-12-15 US US08/357,121 patent/US5650420A/en not_active Expired - Lifetime
-
1995
- 1995-12-12 PT PT95942961T patent/PT797439E/pt unknown
- 1995-12-12 CA CA002207323A patent/CA2207323C/en not_active Expired - Fee Related
- 1995-12-12 WO PCT/US1995/015613 patent/WO1996018395A1/en not_active Application Discontinuation
- 1995-12-12 AU AU44134/96A patent/AU712666B2/en not_active Ceased
- 1995-12-12 CN CNB95196769XA patent/CN1177586C/zh not_active Expired - Fee Related
- 1995-12-12 AT AT95942961T patent/ATE238790T1/de active
- 1995-12-12 KR KR10-2003-7013938A patent/KR100451874B1/ko not_active IP Right Cessation
- 1995-12-12 SI SI9530667T patent/SI0797439T1/xx unknown
- 1995-12-12 DE DE69530606T patent/DE69530606T2/de not_active Expired - Lifetime
- 1995-12-12 ES ES95942961T patent/ES2197213T3/es not_active Expired - Lifetime
- 1995-12-12 NZ NZ298606A patent/NZ298606A/en not_active IP Right Cessation
- 1995-12-12 DK DK95942961T patent/DK0797439T3/da active
- 1995-12-12 KR KR1019970704012A patent/KR100420252B1/ko not_active IP Right Cessation
- 1995-12-12 JP JP51908196A patent/JP4796219B2/ja not_active Expired - Fee Related
- 1995-12-12 EP EP95942961A patent/EP0797439B1/en not_active Expired - Lifetime
-
1997
- 1997-06-13 MX MX9704377A patent/MX9704377A/es unknown
-
2007
- 2007-05-30 JP JP2007143213A patent/JP2007217432A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1996018395A1 (en) | 1996-06-20 |
EP0797439A1 (en) | 1997-10-01 |
SI0797439T1 (en) | 2003-12-31 |
MX9704377A (es) | 1998-07-31 |
CN1177586C (zh) | 2004-12-01 |
JP4796219B2 (ja) | 2011-10-19 |
ES2197213T3 (es) | 2004-01-01 |
KR100420252B1 (ko) | 2004-04-21 |
CN1169677A (zh) | 1998-01-07 |
DK0797439T3 (da) | 2003-08-25 |
DE69530606D1 (de) | 2003-06-05 |
KR100451874B1 (ko) | 2004-10-08 |
US5650420A (en) | 1997-07-22 |
CA2207323C (en) | 2006-10-10 |
AU712666B2 (en) | 1999-11-11 |
DE69530606T2 (de) | 2004-02-19 |
KR20040000443A (ko) | 2004-01-03 |
EP0797439B1 (en) | 2003-05-02 |
NZ298606A (en) | 2001-02-23 |
AU4413496A (en) | 1996-07-03 |
JP2007217432A (ja) | 2007-08-30 |
ATE238790T1 (de) | 2003-05-15 |
CA2207323A1 (en) | 1996-06-20 |
JPH10510809A (ja) | 1998-10-20 |
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