JP2000511782A - GALα1,3GALエピトープを有する抗原性融合タンパク質 - Google Patents
GALα1,3GALエピトープを有する抗原性融合タンパク質Info
- Publication number
- JP2000511782A JP2000511782A JP10545569A JP54556998A JP2000511782A JP 2000511782 A JP2000511782 A JP 2000511782A JP 10545569 A JP10545569 A JP 10545569A JP 54556998 A JP54556998 A JP 54556998A JP 2000511782 A JP2000511782 A JP 2000511782A
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- galα1
- protein according
- human
- antigenic fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.多数のGalα1,3Galエピトープを有する、抗原性融合タンパク質 。 2.組換え細胞株により産生される、請求の範囲第1項に記載の抗原性融合タ ンパク質。 3.前もって形成される抗体、さらにはGalα1,3Galエピトープが発 現される種(該種は、好ましくは抗体産生種とは異なる種である)に由来する組 織または臓器に応答して産生される抗体に結合することができる、請求の範囲第 1項および第2項のいずれか1項に記載の抗原性融合タンパク質。 4.Galα1,3Galエピトープは、ブタ種から誘導されるα1,3ガラ クトトランスフェラーゼにより作成された、前記請求の範囲のいずれか1項に記 載の抗原性融合タンパク質。 5.さらにセレクチンへの結合を媒介する部分を含んでなる、前記請求の範囲 のいずれか1項に記載の抗原性融合タンパク質。 6.セレクチンは、P−セレクチンである、請求の範囲第5項に記載の抗原性 融合タンパク質。 7.セレクチンへの結合を媒介する部分は、高度グリコシル化タンパク質、好 ましくはムチン型のタンパク質である、請求の範囲第5項に記載の抗原性融合タ ンパク質。 8.セレクチンへの結合を媒介する部分は、P−セレクチン糖タンパク質リガ ンド−1(PSGL−1)またはその基本的な部分である、請求の範囲第7項に 記載の抗原性融合タンパク質。 9.免疫グロブリン性を与える部分をさらに含んでなる、前記請求の範囲のい ずれか1項に記載の抗原性融合タンパク質。 10.免疫グロブリン性を与える部分は、免疫グロブリンまたはその部分、好 ましくはIgGまたはその部分である、請求の範囲第9項に記載の抗原性融合タ ンパク質。 11.免疫グロブリン性を与える部分は、免疫グロブリン(好ましくはIgG )のFc部、またはその基本的な部分である、請求の範囲第10項に記載の抗 原性融合タンパク質。 12.免疫グロブリン性を与える部分は、IgG2b、好ましくはそのFc部で ある、請求の範囲第11項に記載の抗原性融合タンパク質。 13.免疫グロブリン性を与える部分は、ヒト由来である、請求の範囲第9項 〜第12項のいずれか1項に記載の抗原性融合タンパク質。 14.免疫グロブリン性を与える部分は、非ヒト由来であり、そして好ましく はマウスから誘導される、請求の範囲第9項〜第12項のいずれか1項に記載の 抗原性融合タンパク質。 15.請求の範囲第1項〜第14項のいずれか1項に記載の融合タンパク質、 またはその誘導体または変種をコードするcDNA配列を含んでなる、cDNA 分子。 16.適切な調節およびシグナル配列と共に請求の範囲第15項に記載のcD NA分子を含んでなる、ベクター。 17.請求の範囲第16項に記載のベクターでトランスフェクションした哺乳 動物細胞。 18.COS細胞である、請求の範囲第17項に記載の哺乳動物細胞。 19.外来組織または臓器に対して作成された抗体からの血漿の精製に使用す るための吸収物質であって、請求の範囲第1項〜第14項のいずれか1項に記載 の融合タンパク質を含んでなる、上記吸収物質。 20.異種移植を受けるべき患者の超急性拒絶反応を防止するための方法であ って、患者から血漿を抜き取り、血漿を、請求の範囲第1項〜第14項のいずれ か1項に記載の融合タンパク質と接触させて、そこに抗ブタ抗体を結合させ、そ の後血漿を患者に再注入することを含んでなる、上記方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9701127-4 | 1997-03-26 | ||
SE9701127A SE9701127D0 (sv) | 1997-03-26 | 1997-03-26 | Antigenic fusionprotein carrying GALal, 3GAL epitopes |
PCT/SE1998/000555 WO1998042750A1 (en) | 1997-03-26 | 1998-03-26 | ANTIGENIC FUSIONPROTEIN CARRYING GALα1,3GAL EPITOPES |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2000511782A true JP2000511782A (ja) | 2000-09-12 |
JP2000511782A5 JP2000511782A5 (ja) | 2005-11-10 |
JP4099239B2 JP4099239B2 (ja) | 2008-06-11 |
Family
ID=20406335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54556998A Expired - Fee Related JP4099239B2 (ja) | 1997-03-26 | 1998-03-26 | GALα1、3GALエピトープを有する抗原性融合タンパク質 |
Country Status (12)
Country | Link |
---|---|
US (3) | US6943239B2 (ja) |
EP (2) | EP1700868A3 (ja) |
JP (1) | JP4099239B2 (ja) |
AT (1) | ATE315047T1 (ja) |
AU (1) | AU751760B2 (ja) |
BR (1) | BR9804826A (ja) |
CA (1) | CA2255765A1 (ja) |
DE (1) | DE69833106T2 (ja) |
DK (1) | DK0923606T3 (ja) |
ES (1) | ES2258297T3 (ja) |
SE (1) | SE9701127D0 (ja) |
WO (1) | WO1998042750A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005535699A (ja) * | 2002-08-09 | 2005-11-24 | レコファーマ アーベー | ムチン−免疫グロブリン融合タンパク質 |
Families Citing this family (42)
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EP1409542A2 (en) * | 2001-07-20 | 2004-04-21 | Absorber AB | Blood group antigen fusion polypeptides and methods of use thereof |
CA2483476A1 (en) * | 2002-04-22 | 2003-10-30 | Absorber, Ab | Fusion polypeptides and methods for inhibiting microbial adhesion |
ES2385032T3 (es) * | 2002-04-22 | 2012-07-17 | Recopharma Ab | Vacunas de polipéptido de fusión de mucina, composiciones y métodos de uso de las mismas |
JP5183010B2 (ja) | 2002-05-16 | 2013-04-17 | グリコミメティクス, インコーポレイテッド | セレクチンによって媒介される機能を阻害するための化合物および方法 |
CA2490703A1 (en) * | 2002-07-03 | 2004-01-15 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis |
US20050076759A1 (en) * | 2003-10-08 | 2005-04-14 | Brian Westfall | Linear saw with stab-cut bevel capability |
US20040219158A1 (en) * | 2003-05-02 | 2004-11-04 | Glycomimetics, Inc. | Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria |
US7459523B2 (en) * | 2003-11-12 | 2008-12-02 | Wisconsin Alumni Research Foundation | Equine P-selectin glycoprotein ligand-1 and uses thereof |
JP2007524658A (ja) * | 2003-11-19 | 2007-08-30 | グリコミメティクス, インコーポレイテッド | E−およびp−セレクチンの両方のための糖模倣物アンタゴニスト |
ATE383367T1 (de) * | 2003-11-19 | 2008-01-15 | Glycomimetics Inc | Spezifischer antagonist sowohl für e- als auch p- selektine |
WO2006001348A1 (ja) * | 2004-06-23 | 2006-01-05 | Japan Science And Technology Agency | 浸潤抑制及び細胞殺傷剤 |
US8201377B2 (en) * | 2004-11-05 | 2012-06-19 | Faus Group, Inc. | Flooring system having multiple alignment points |
WO2006127906A1 (en) * | 2005-05-25 | 2006-11-30 | Glycomimetics, Inc. | Heterobifunctional compounds for selectin inhibition |
ES2375979T3 (es) * | 2005-08-09 | 2012-03-07 | Glycomimetics, Inc. | Inhibidores glicomiméticos de la lectina pa-il, lectina pa-iil o ambas lectinas de pseudomonas. |
CN103626813B (zh) | 2005-09-02 | 2017-05-03 | 糖模拟物有限公司 | 异型双功能全选择素抑制剂 |
US20070113297A1 (en) * | 2005-09-13 | 2007-05-17 | Yongguang Yang | Methods and compositions for inhibition of immune responses |
EP2264060B1 (en) * | 2006-01-26 | 2014-04-23 | Recopharma AB | Compositions and methods for inhibiting viral adhesion |
US20070178447A1 (en) * | 2006-01-31 | 2007-08-02 | Bethyl Laboratories, Inc. | Method for decreasing interference in results of immunochemical methods |
WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
JP5298020B2 (ja) | 2006-10-12 | 2013-09-25 | グリコミメティクス, インコーポレイテッド | ヘキソースおよびn−アセチルヘキソサミンの糖模倣体置換 |
US7998486B2 (en) * | 2006-10-25 | 2011-08-16 | Newlink Genetics Corporation | Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes |
CA2677747A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
EP2318015B1 (en) * | 2008-06-13 | 2013-08-07 | GlycoMimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
JP5726171B2 (ja) | 2009-05-01 | 2015-05-27 | グリコミメティックス インコーポレイテッド | E−セレクチンおよびcxcr4ケモカイン受容体のヘテロ二官能性阻害剤 |
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ES2668045T3 (es) | 2012-12-07 | 2018-05-16 | Glycomimetics, Inc. | Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas |
EP3227310B1 (en) | 2014-12-03 | 2019-07-31 | GlycoMimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
JP7069136B2 (ja) | 2016-10-07 | 2022-05-17 | グリコミメティクス, インコーポレイテッド | 極めて強力な多量体e-セレクチンアンタゴニスト |
EP3596096A1 (en) | 2017-03-15 | 2020-01-22 | GlycoMimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
WO2019133878A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
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US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
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AU661854B2 (en) * | 1991-06-27 | 1995-08-10 | Bristol-Myers Squibb Company | CTL4A receptor, fusion proteins containing it and uses thereof |
ATE501254T1 (de) * | 1992-10-23 | 2011-03-15 | Genetics Inst Llc | P- selectin ligandenprotein |
JP4038236B2 (ja) * | 1993-03-16 | 2008-01-23 | オースチン・リサーチ・インスティテュート | 異種移植治療におけるブタGa1α(1,3)ガラクトシルトランスフェラーゼの使用 |
GB9517758D0 (en) | 1995-08-31 | 1995-11-01 | Imutran Ltd | Compositions and their uses |
-
1997
- 1997-03-26 SE SE9701127A patent/SE9701127D0/xx unknown
-
1998
- 1998-03-26 DK DK98912863T patent/DK0923606T3/da active
- 1998-03-26 CA CA002255765A patent/CA2255765A1/en not_active Abandoned
- 1998-03-26 AU AU67551/98A patent/AU751760B2/en not_active Ceased
- 1998-03-26 EP EP06075010A patent/EP1700868A3/en not_active Withdrawn
- 1998-03-26 DE DE69833106T patent/DE69833106T2/de not_active Expired - Lifetime
- 1998-03-26 EP EP98912863A patent/EP0923606B1/en not_active Expired - Lifetime
- 1998-03-26 US US09/194,396 patent/US6943239B2/en not_active Expired - Fee Related
- 1998-03-26 BR BR9804826-0A patent/BR9804826A/pt not_active Application Discontinuation
- 1998-03-26 WO PCT/SE1998/000555 patent/WO1998042750A1/en active IP Right Grant
- 1998-03-26 JP JP54556998A patent/JP4099239B2/ja not_active Expired - Fee Related
- 1998-03-26 ES ES98912863T patent/ES2258297T3/es not_active Expired - Lifetime
- 1998-03-26 AT AT98912863T patent/ATE315047T1/de not_active IP Right Cessation
-
2005
- 2005-06-15 US US11/153,082 patent/US20050255099A1/en not_active Abandoned
-
2009
- 2009-07-22 US US12/507,626 patent/US20090286963A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005535699A (ja) * | 2002-08-09 | 2005-11-24 | レコファーマ アーベー | ムチン−免疫グロブリン融合タンパク質 |
JP4648001B2 (ja) * | 2002-08-09 | 2011-03-09 | レコファーマ アーベー | ムチン−免疫グロブリン融合タンパク質 |
Also Published As
Publication number | Publication date |
---|---|
DE69833106T2 (de) | 2006-08-31 |
US20090286963A1 (en) | 2009-11-19 |
CA2255765A1 (en) | 1998-10-01 |
BR9804826A (pt) | 2000-01-25 |
US20020028205A1 (en) | 2002-03-07 |
ES2258297T3 (es) | 2006-08-16 |
US6943239B2 (en) | 2005-09-13 |
EP0923606A1 (en) | 1999-06-23 |
AU6755198A (en) | 1998-10-20 |
SE9701127D0 (sv) | 1997-03-26 |
US20050255099A1 (en) | 2005-11-17 |
AU751760B2 (en) | 2002-08-29 |
JP4099239B2 (ja) | 2008-06-11 |
ATE315047T1 (de) | 2006-02-15 |
DE69833106D1 (de) | 2006-03-30 |
EP1700868A2 (en) | 2006-09-13 |
EP1700868A3 (en) | 2007-12-12 |
DK0923606T3 (da) | 2006-05-22 |
WO1998042750A1 (en) | 1998-10-01 |
EP0923606B1 (en) | 2006-01-04 |
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