DK0871474T3 - Generering af humant insulin - Google Patents
Generering af humant insulinInfo
- Publication number
- DK0871474T3 DK0871474T3 DK95907193T DK95907193T DK0871474T3 DK 0871474 T3 DK0871474 T3 DK 0871474T3 DK 95907193 T DK95907193 T DK 95907193T DK 95907193 T DK95907193 T DK 95907193T DK 0871474 T3 DK0871474 T3 DK 0871474T3
- Authority
- DK
- Denmark
- Prior art keywords
- human insulin
- folded
- polypeptide
- insulin generation
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/013268 WO1996020724A1 (en) | 1994-12-29 | 1994-12-29 | Generation of human insulin |
Publications (2)
Publication Number | Publication Date |
---|---|
DK0871474T3 true DK0871474T3 (da) | 2007-05-07 |
DK0871474T4 DK0871474T4 (da) | 2012-01-09 |
Family
ID=22243290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95907193.7T DK0871474T4 (da) | 1994-12-29 | 1994-12-29 | Fremstilling af human insulin |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0871474B2 (da) |
JP (1) | JP4624495B2 (da) |
AT (1) | ATE350053T1 (da) |
AU (1) | AU698872B2 (da) |
BR (1) | BR9408638A (da) |
CA (1) | CA2208095C (da) |
CZ (1) | CZ290079B6 (da) |
DE (2) | DE95907193T1 (da) |
DK (1) | DK0871474T4 (da) |
ES (1) | ES2279510T5 (da) |
HK (1) | HK1013594A1 (da) |
HU (1) | HU223718B1 (da) |
NZ (1) | NZ279002A (da) |
PL (1) | PL180818B1 (da) |
PT (1) | PT871474E (da) |
WO (1) | WO1996020724A1 (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19735711C2 (de) | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
WO1999050302A1 (en) * | 1998-03-31 | 1999-10-07 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production |
JP3406244B2 (ja) | 1999-04-30 | 2003-05-12 | 伊藤ハム株式会社 | 新規な融合蛋白質からの組み換えインスリンの製造方法 |
WO2001072323A2 (en) | 2000-03-24 | 2001-10-04 | Genentech, Inc. | Use of insulin for the treatment of cartilagenous disorders |
US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
EP1383540B1 (en) | 2000-07-31 | 2009-04-29 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
DE602004014251D1 (de) | 2003-01-31 | 2008-07-17 | Organon Nv | Verfahren zur proteinisolierung unteranoxischen bedingungen |
JP4668902B2 (ja) | 2003-08-07 | 2011-04-13 | ヒーラー リミテッド | 創傷治癒を促進するための薬剤組成物及び方法 |
AU2011282988A1 (en) * | 2010-07-28 | 2013-01-31 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
WO2012048856A1 (en) | 2010-10-12 | 2012-04-19 | Glucometrix Pvs Gmbh | Proinsulin with helper sequence |
WO2012098009A1 (en) | 2011-01-21 | 2012-07-26 | Glucometrix Ag | Chimeric polypeptide comprising a membrane protein and an insulin precursor |
EP2867250A2 (en) | 2012-04-04 | 2015-05-06 | GlucoMetrix AG | Proinsulin with enhanced helper sequence |
CA2866491A1 (en) * | 2014-10-02 | 2016-04-02 | Clay Purdy | Synthetic acid compositions and uses thereof |
JP2018531007A (ja) * | 2015-09-24 | 2018-10-25 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリンの製造方法 |
PL239062B1 (pl) * | 2016-01-22 | 2021-11-02 | Inst Biotechnologii I Antybiotykow | Sposób wytwarzania insuliny i jej pochodnych |
AU2017322552B2 (en) | 2016-09-06 | 2021-12-02 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | Proinsulin derivatives |
EP3807306A4 (en) * | 2018-06-18 | 2022-04-06 | Unichem Laboratories Limited | LEADER SEQUENCE FOR HIGHER EXPRESSION OF RECOMBINANT PROTEINS |
CN113226284A (zh) | 2018-09-25 | 2021-08-06 | 美药星制药股份有限公司 | 高度纯化的重组人胰岛素(rhi)api及其生产方法 |
CN113527505A (zh) * | 2020-04-15 | 2021-10-22 | 博锐生物科技有限公司 | 一种多肽和包含该多肽的药物组合物以及它们的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4430266A (en) * | 1980-11-28 | 1984-02-07 | Eli Lilly And Company | Process for producing an insulin precursor |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
ATE63757T1 (de) † | 1985-03-28 | 1991-06-15 | Chiron Corp | Expression durch verwendung von fusionsgenen fuer proteinproduktion. |
US5342921A (en) * | 1985-03-28 | 1994-08-30 | Chiron Corporation | Superoxide dismutase fusion polypeptides for expression of mammalian proteins |
DE3901719A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur herstellung eines insulinvorlaeufers |
DE3901718A1 (de) † | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern |
US5126249A (en) * | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
US5227293A (en) * | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
CA2089541A1 (en) * | 1992-02-18 | 1993-08-19 | Bruce H. Frank | Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 |
DE19701167A1 (de) * | 1997-01-15 | 1998-07-23 | Siemens Ag | Chipkarte |
-
1994
- 1994-12-29 DK DK95907193.7T patent/DK0871474T4/da active
- 1994-12-29 PL PL94321039A patent/PL180818B1/pl unknown
- 1994-12-29 HU HU9800292A patent/HU223718B1/hu active IP Right Grant
- 1994-12-29 EP EP95907193A patent/EP0871474B2/en not_active Expired - Lifetime
- 1994-12-29 DE DE95907193T patent/DE95907193T1/de active Pending
- 1994-12-29 AU AU15500/95A patent/AU698872B2/en not_active Expired
- 1994-12-29 NZ NZ279002A patent/NZ279002A/xx not_active IP Right Cessation
- 1994-12-29 BR BR9408638-9A patent/BR9408638A/pt not_active Application Discontinuation
- 1994-12-29 DE DE69434909T patent/DE69434909T3/de not_active Expired - Lifetime
- 1994-12-29 JP JP52090996A patent/JP4624495B2/ja not_active Expired - Lifetime
- 1994-12-29 PT PT95907193T patent/PT871474E/pt unknown
- 1994-12-29 AT AT95907193T patent/ATE350053T1/de active
- 1994-12-29 CZ CZ19972031A patent/CZ290079B6/cs not_active IP Right Cessation
- 1994-12-29 WO PCT/US1994/013268 patent/WO1996020724A1/en active IP Right Grant
- 1994-12-29 CA CA002208095A patent/CA2208095C/en not_active Expired - Lifetime
- 1994-12-29 ES ES95907193T patent/ES2279510T5/es not_active Expired - Lifetime
-
1998
- 1998-09-26 HK HK98110997A patent/HK1013594A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP4624495B2 (ja) | 2011-02-02 |
WO1996020724A1 (en) | 1996-07-11 |
HK1013594A1 (en) | 1999-09-03 |
EP0871474B2 (en) | 2011-09-21 |
BR9408638A (pt) | 2004-09-21 |
HU223718B1 (hu) | 2004-12-28 |
PL180818B1 (pl) | 2001-04-30 |
DE69434909T3 (de) | 2012-02-09 |
DE69434909T2 (de) | 2007-08-09 |
HUT78070A (hu) | 1999-08-30 |
CZ290079B6 (cs) | 2002-05-15 |
PL321039A1 (en) | 1997-11-24 |
CZ203197A3 (cs) | 1998-09-16 |
AU1550095A (en) | 1996-07-24 |
JPH10511849A (ja) | 1998-11-17 |
EP0871474A4 (en) | 2004-08-18 |
AU698872B2 (en) | 1998-11-12 |
NZ279002A (en) | 1999-02-25 |
DE95907193T1 (de) | 2005-02-10 |
ATE350053T1 (de) | 2007-01-15 |
EP0871474A1 (en) | 1998-10-21 |
PT871474E (pt) | 2007-02-28 |
DK0871474T4 (da) | 2012-01-09 |
DE69434909D1 (de) | 2007-02-15 |
ES2279510T5 (es) | 2012-01-19 |
CA2208095C (en) | 2006-11-28 |
CA2208095A1 (en) | 1996-07-11 |
EP0871474B1 (en) | 2007-01-03 |
ES2279510T3 (es) | 2007-08-16 |
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