ES2075155T3 - Separacion enzimatica de una secuencia de una proteina con amino terminal. - Google Patents

Separacion enzimatica de una secuencia de una proteina con amino terminal.

Info

Publication number
ES2075155T3
ES2075155T3 ES90304890T ES90304890T ES2075155T3 ES 2075155 T3 ES2075155 T3 ES 2075155T3 ES 90304890 T ES90304890 T ES 90304890T ES 90304890 T ES90304890 T ES 90304890T ES 2075155 T3 ES2075155 T3 ES 2075155T3
Authority
ES
Spain
Prior art keywords
protein
sequence
terminal amino
compounds
enzymatic separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90304890T
Other languages
English (en)
Inventor
Gerald Wayne Becker
Thomas Charles Furman
Warren C Mackellar
James Patrick Mcdonough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2075155T3 publication Critical patent/ES2075155T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

EL DESCUBRIMIENTO SE REFIERE A UN NUEVO COMPUESTO Y A UN PROCESO PARA LA CONVERSION CONTROLADA DE DICHOS COMPUESTOS PARA PRODUCIR UNA PROTEINA QUE COMPRENDE UNA SECUENCIA DE ACIDO AMINO QUE ES UTIL COMO PRECURSORA DE LA INSULINA HUMANA O DE UNA INSULINA HUMANA MODIFICADA, LA PARTE DEL TERMINO AMINO DE DICHA SECUENCIA NO DEFINE UN PUNTO DE DETENCION DE LA SEPARACION DEL DIPEPTIDO C DE CATEPSINA. EL COMPUESTO TIENE LA FORMULA MET-Y-PROTEINA, EN LA CUAL Y ES TYR O ARG.
ES90304890T 1989-05-09 1990-05-04 Separacion enzimatica de una secuencia de una proteina con amino terminal. Expired - Lifetime ES2075155T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,472 US5126249A (en) 1989-05-09 1989-05-09 Enzymatic removal of a protein amino-terminal sequence

Publications (1)

Publication Number Publication Date
ES2075155T3 true ES2075155T3 (es) 1995-10-01

Family

ID=23372543

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90304890T Expired - Lifetime ES2075155T3 (es) 1989-05-09 1990-05-04 Separacion enzimatica de una secuencia de una proteina con amino terminal.

Country Status (12)

Country Link
US (2) US5126249A (es)
EP (1) EP0397420B1 (es)
JP (1) JP2592981B2 (es)
AT (1) ATE124997T1 (es)
AU (1) AU630951B2 (es)
CA (1) CA2016049A1 (es)
DE (1) DE69020794T2 (es)
DK (1) DK0397420T3 (es)
ES (1) ES2075155T3 (es)
HU (1) HU215582B (es)
IE (1) IE67531B1 (es)
IL (1) IL94305A (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
IL104086A (en) * 1991-12-18 1998-03-10 Lilly Co Eli Translational activating oligonucleotide sequence useful for the high level expression of polypeptides and a method for producing such polypeptides
CA2089541A1 (en) * 1992-02-18 1993-08-19 Bruce H. Frank Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
TW257792B (es) * 1992-10-01 1995-09-21 Lilly Co Eli
JP2887060B2 (ja) * 1993-06-30 1999-04-26 日清製粉株式会社 グリセンチンの生産方法
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
JP2887063B2 (ja) * 1993-12-28 1999-04-26 日清製粉株式会社 グリセンチンの製造方法
DK0759931T3 (da) * 1994-05-09 1999-07-12 Unizyme Lab Aps Enzymatisk fremgangsmåde til fremstilling af et ønsket protein ud fra et aminoterminalekstenderet protein
BR9408638A (pt) * 1994-12-29 2004-09-21 Bio Technology General Corp Geração de insulina humana
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
US6008041A (en) * 1996-05-08 1999-12-28 Eli Lilly And Company Bovine dipeptidylaminopeptidase 1
JP2000512635A (ja) * 1996-06-07 2000-09-26 イーライ リリー アンド カンパニー Ｏｂタンパク質を結合するタンパク質
DE19943177C2 (de) * 1999-09-09 2002-10-24 Dieter Jenne Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten
IL141647A0 (en) * 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
PL205888B1 (pl) * 2001-07-06 2010-06-30 Lg Life Sciences Ltd Aminopeptydaza, gen kodujący aminopeptydazę, wektor ekspresyjny, transformant Escherichia coli i sposób wytwarzania białka typu naturalnego
EP1583562B1 (en) * 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
DK1594434T3 (da) * 2003-01-14 2017-01-02 Yeda Res & Dev Company Ltd At The Weizmann Inst Of Science Parenterale formuleringer af peptide til behandling af systemisk lupus erythematosus
EA008438B1 (ru) * 2003-01-14 2007-06-29 Тева Фармасьютикал Индастриз, Лтд. Парентеральные композиции пептида для лечения системной красной волчанки
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
JP5064212B2 (ja) 2004-05-05 2012-10-31 ヴァロリザーシヨン−ルシェルシュ，ソシエテ・アン・コマンディット インターロイキン−１受容体アンタゴニスト、組成物、及び治療方法
AU2006264567A1 (en) 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
EP2789628A3 (en) 2007-05-29 2015-03-04 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
PT2279008T (pt) 2008-04-18 2019-05-20 Angiochem Inc Composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e utilização
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
CA2740316A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of glp-1 agonists and uses thereof
CN102307904A (zh) 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US9161988B2 (en) 2009-07-02 2015-10-20 Angiochem Inc. Multimeric peptide conjugates and uses thereof
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
US9707275B2 (en) * 2012-12-19 2017-07-18 Wockhardt Limited Stable aqueous composition comprising human insulin or an analogue or derivative thereof
US11326255B2 (en) 2013-02-07 2022-05-10 Uchicago Argonne, Llc ALD reactor for coating porous substrates
JP6823055B2 (ja) 2015-06-15 2021-01-27 アンジオケム インコーポレーテッド 軟髄膜癌腫症の治療方法
US11111578B1 (en) 2020-02-13 2021-09-07 Uchicago Argonne, Llc Atomic layer deposition of fluoride thin films
US11901169B2 (en) 2022-02-14 2024-02-13 Uchicago Argonne, Llc Barrier coatings

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
EP0489711B1 (en) * 1984-08-16 2003-10-01 Savient Pharmaceuticals, Inc. Method for producing human growth hormone
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
IL91771A0 (en) * 1988-09-30 1990-06-10 Lilly Co Eli Increased expression of small molecular weight recombinant proteins
AU641631B2 (en) * 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29

Also Published As

Publication number Publication date
EP0397420A1 (en) 1990-11-14
DE69020794T2 (de) 1995-12-14
ATE124997T1 (de) 1995-07-15
US5126249A (en) 1992-06-30
HU902697D0 (en) 1990-09-28
IE901673L (en) 1990-11-09
CA2016049A1 (en) 1990-11-09
HU215582B (hu) 1999-01-28
EP0397420B1 (en) 1995-07-12
IE67531B1 (en) 1996-04-03
IL94305A0 (en) 1991-03-10
DE69020794D1 (de) 1995-08-17
HUT54213A (en) 1991-01-28
IL94305A (en) 1995-12-08
AU630951B2 (en) 1992-11-12
JPH0334995A (ja) 1991-02-14
AU5483390A (en) 1990-11-15
US5352769A (en) 1994-10-04
JP2592981B2 (ja) 1997-03-19
DK0397420T3 (da) 1995-08-21

Similar Documents

Publication Publication Date Title
ES2075155T3 (es) Separacion enzimatica de una secuencia de una proteina con amino terminal.
AU595290B2 (en) Process for producing human epidermal growth factor and analogs thereof
DE69316405D1 (de) Verfahren zur fermentativen Herstellung von Aminosäuren
DE68919246D1 (de) Verfahren zur Herstellung von Aminosäuren.
ES2176456T3 (es) Procedimiento de preparacion de un compuesto inhibidor del vih proteasa.
DE69007800D1 (de) Verfahren zur fermentativen Herstellung von L-Arginin.
AU4971385A (en) A process for the cleavage of peptides and proteins at the methionyl bond
IT1202426B (it) Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono
ES2009588A6 (es) Un metodo para la preparacion de un polipeptido.
ES2185628T3 (es) Procedimiento para preparar proteinas modificadas.
AU2851389A (en) Synthetic peptides and mixtures thereof for detecting hiv antibodies
DE68910771D1 (de) Verfahren zur Herstellung von verbessertem Proteinhydrolysat.
DE69010155D1 (de) Verfahren zur Trennung von Aminosäuren.
DE3561201D1 (en) Medicaments containing tripeptides
EP0316725A3 (de) Verfahren zur enzymatischen Peptidsynthese mit mindestens einer nicht-proteinogenen Aminsäure sowie die neuen, bei der Synthese anfallenden Peptide
ATE143974T1 (de) Peptide des hiv-gag proteins, ihre herstellung und verwendung
ES2166545T3 (es) Procedimiento de preparacion de un aminoacido activado.
ATE224403T1 (de) Verwendung von kaseinfragmenten als wachstumerförderer
CA2285700A1 (en) Renin-active substance
ATE110775T1 (de) Verfahren zur herstellung von hirudin.
AU569677B1 (en) Production of cystine from cysteine obtained by the enzymatic or fermentative method
AU7470681A (en) Glicentin related purified peptide having 30 amino acids
DE3887854D1 (de) Verfahren zur Herstellung von Dipeptiden.
ES2114004T3 (es) Procedimiento de preparacion de peptidos con un residuo prolina amidado en la posicion c-terminal.
JPS6450852A (en) Manufacture of l,l or d,d or racemic n6- benzyloxycarbonyl-2,6-diaminopimelamic acid

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 397420

Country of ref document: ES