ES2009588A6 - Un metodo para la preparacion de un polipeptido. - Google Patents
Un metodo para la preparacion de un polipeptido.Info
- Publication number
- ES2009588A6 ES2009588A6 ES8801014A ES8801014A ES2009588A6 ES 2009588 A6 ES2009588 A6 ES 2009588A6 ES 8801014 A ES8801014 A ES 8801014A ES 8801014 A ES8801014 A ES 8801014A ES 2009588 A6 ES2009588 A6 ES 2009588A6
- Authority
- ES
- Spain
- Prior art keywords
- recombinant yeast
- purifying
- expression product
- yeast expression
- immunogenic recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 240000009188 Phyllostachys vivax Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
Abstract
UN METODO PARA LA PREPARACION DE UN POLIPEPTIDO, EXPRESADO EN LEVADURA, COMPRENDE: A) FACILITAR UNA LEVADURA TRANSFORMADA POR UN VECTOR DE EXPRESION DE LEVADURA QUE INCORPORA UN FRAGMENTO EXPRESABLE DE ADN QUE CODIFICA UN POLIPEPTIDO DE P. VIVAX CS CONSISTENTE ESENCIALMENTE EN LA SECUENCIA DE AMINOACIDOS: A E P K N P R E N K L K Q P G D R A D G Q P A G D R A D G Q P A G D R A D G Q P A G D R A A G Q P A G D R A D G Q P A G D R A D G Q P A G D R A D G Q P A G D R A D G Q P A G D R A A G Q P A G D R A A G Q P A G D R A D G Q P A G D R A A G Q P A G D R A D G Q P A G D R A A G Q P A G D R A D G Q P A G D R A A G Q P A G D R A A G Q P A G D R A A G Q P A G D R A A G Q P A G N G A G G Q A A G G N A G G Q G Q N N E G A N A P N E K S V K E Y L D K V R A T V G T E W T P B) CULTIVAR DICHA LEVADURA EN CONDICIONES POR LAS CUALES SE EXPRESA DICHO POLIPEPTIDO DE P. VIVAX; Y C) RECUPERAR DICHO POLIPEPTIDO EXPRESADODE P. VIVAX CS DE DICHA LEVADURA CULTIVADA. SE OBTIENE ASI UN POLIPEPTIDO QUE COMPRENDE LASECUENCIA DE AMINOACIDOS QUE LLEVA INCORPORADA UNA PORCION DE LA PROTEINA CIRCUMSPOROZOITA (CS DE P. VIVAX, QUE INCLUYE LA REGION DEL EPITOPO INMUNODOMINANTE REPETITIVO DE DICHA PROTEINA. TIENE UTILIDAD EN LA VACUNA CONTRA LA MALARIA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/032,327 US4826957A (en) | 1985-07-12 | 1987-03-30 | Immunogenic recombinant yeast expression product and method for purifying it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2009588A6 true ES2009588A6 (es) | 1989-10-01 |
Family
ID=21864347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8801014A Expired ES2009588A6 (es) | 1987-03-30 | 1988-03-30 | Un metodo para la preparacion de un polipeptido. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4826957A (es) |
| EP (1) | EP0307472B1 (es) |
| JP (1) | JPH01503517A (es) |
| AT (1) | ATE81136T1 (es) |
| AU (1) | AU615451B2 (es) |
| DE (1) | DE3875043T2 (es) |
| DK (1) | DK665688A (es) |
| ES (1) | ES2009588A6 (es) |
| HK (1) | HK112693A (es) |
| IL (1) | IL85906A0 (es) |
| NZ (1) | NZ224088A (es) |
| PH (1) | PH27079A (es) |
| WO (1) | WO1988007550A1 (es) |
| ZA (1) | ZA882269B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0229829B1 (en) * | 1985-07-12 | 1995-02-22 | New York University | Immunogenic peptide antigen corresponding to plasmodium vivax circumsporozoite protein |
| US4997647A (en) * | 1987-03-30 | 1991-03-05 | New York University | Vaccine against the sporozoite stage of malaria |
| IL85905A0 (en) * | 1987-03-30 | 1988-09-30 | Univ New York | Immunogenic recombinant yeast expression product and method for purifying it |
| US5853739A (en) * | 1988-05-02 | 1998-12-29 | The United States Of America As Represented By The Department Of Health And Human Services | Transmission-blocking vaccine against malaria |
| GB8812214D0 (en) * | 1988-05-24 | 1988-06-29 | Hoffmann La Roche | Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope |
| AU7744491A (en) * | 1990-04-16 | 1991-11-11 | Strohtech, Inc. | Expression of recombinant hemoglobin in yeast |
| US5095093A (en) * | 1990-11-06 | 1992-03-10 | The United States Of America As Represented By The Secretary Of The Navy | Protective four amino acid epitope against Plasmodium vivax malaria |
| WO1992014486A1 (en) | 1991-02-22 | 1992-09-03 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY, THE U.S. DEPARTMENT OF COMMERCE | Transmission blocking vaccine against malaria |
| WO1993011157A1 (en) * | 1991-11-27 | 1993-06-10 | The Council Of The Queensland Institute Of Medical Research | MALARIAL VACCINE AND PEPTIDES COMPRISING HUMAN T-CELL EPITOPE OF CIRCUMSPOROZOITE PROTEIN OF $i(P.VIVAX) |
| US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| US6737262B1 (en) * | 2000-07-11 | 2004-05-18 | Robert I. Bolla | Animal feed containing polypeptides |
| US7790186B2 (en) | 2005-01-18 | 2010-09-07 | The United States Of America As Represented By The Secretary Of The Army | Plasmodium vivax hybrid circumsporozoite protein and vaccine |
| EP2040743B1 (en) * | 2006-07-18 | 2013-10-02 | GlaxoSmithKline Biologicals S.A. | Vaccines for malaria |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4466917A (en) * | 1981-02-12 | 1984-08-21 | New York University | Malaria vaccine |
| ATE70308T1 (de) * | 1984-09-12 | 1991-12-15 | Chiron Corp | Hybridpartikel-immunogene. |
| EP0229829B1 (en) * | 1985-07-12 | 1995-02-22 | New York University | Immunogenic peptide antigen corresponding to plasmodium vivax circumsporozoite protein |
| IL85905A0 (en) * | 1987-03-30 | 1988-09-30 | Univ New York | Immunogenic recombinant yeast expression product and method for purifying it |
-
1987
- 1987-03-30 US US07/032,327 patent/US4826957A/en not_active Expired - Fee Related
-
1988
- 1988-03-29 IL IL85906A patent/IL85906A0/xx unknown
- 1988-03-30 DE DE8888904772T patent/DE3875043T2/de not_active Expired - Fee Related
- 1988-03-30 AT AT88904772T patent/ATE81136T1/de not_active IP Right Cessation
- 1988-03-30 ES ES8801014A patent/ES2009588A6/es not_active Expired
- 1988-03-30 WO PCT/US1988/001151 patent/WO1988007550A1/en active IP Right Grant
- 1988-03-30 NZ NZ224088A patent/NZ224088A/en unknown
- 1988-03-30 EP EP88904772A patent/EP0307472B1/en not_active Expired - Lifetime
- 1988-03-30 ZA ZA882269A patent/ZA882269B/xx unknown
- 1988-03-30 JP JP63504552A patent/JPH01503517A/ja active Pending
- 1988-03-30 PH PH36721A patent/PH27079A/en unknown
- 1988-03-30 AU AU17914/88A patent/AU615451B2/en not_active Ceased
- 1988-11-29 DK DK665688A patent/DK665688A/da not_active Application Discontinuation
-
1993
- 1993-10-21 HK HK1126/93A patent/HK112693A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE81136T1 (de) | 1992-10-15 |
| HK112693A (en) | 1993-10-29 |
| EP0307472B1 (en) | 1992-09-30 |
| PH27079A (en) | 1993-02-01 |
| DE3875043D1 (de) | 1992-11-05 |
| NZ224088A (en) | 1990-12-21 |
| DE3875043T2 (de) | 1993-02-25 |
| DK665688D0 (da) | 1988-11-29 |
| ZA882269B (en) | 1988-09-22 |
| AU1791488A (en) | 1988-11-02 |
| JPH01503517A (ja) | 1989-11-30 |
| US4826957A (en) | 1989-05-02 |
| WO1988007550A1 (en) | 1988-10-06 |
| EP0307472A1 (en) | 1989-03-22 |
| EP0307472A4 (en) | 1989-06-27 |
| DK665688A (da) | 1989-01-30 |
| AU615451B2 (en) | 1991-10-03 |
| IL85906A0 (en) | 1988-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000301 |