DK0397420T3 - Enzymatisk fjernelse af en aminoterminal proteinsekvens - Google Patents

Enzymatisk fjernelse af en aminoterminal proteinsekvens

Info

Publication number
DK0397420T3
DK0397420T3 DK90304890.8T DK90304890T DK0397420T3 DK 0397420 T3 DK0397420 T3 DK 0397420T3 DK 90304890 T DK90304890 T DK 90304890T DK 0397420 T3 DK0397420 T3 DK 0397420T3
Authority
DK
Denmark
Prior art keywords
amino
protein sequence
terminal protein
compounds
enzymatic removal
Prior art date
Application number
DK90304890.8T
Other languages
English (en)
Inventor
Gerald Wayne Becker
Thomas Charles Furman
Warren C Mackellar
James Patrick Mcdonough
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0397420T3 publication Critical patent/DK0397420T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK90304890.8T 1989-05-09 1990-05-04 Enzymatisk fjernelse af en aminoterminal proteinsekvens DK0397420T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,472 US5126249A (en) 1989-05-09 1989-05-09 Enzymatic removal of a protein amino-terminal sequence

Publications (1)

Publication Number Publication Date
DK0397420T3 true DK0397420T3 (da) 1995-08-21

Family

ID=23372543

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90304890.8T DK0397420T3 (da) 1989-05-09 1990-05-04 Enzymatisk fjernelse af en aminoterminal proteinsekvens

Country Status (12)

Country Link
US (2) US5126249A (da)
EP (1) EP0397420B1 (da)
JP (1) JP2592981B2 (da)
AT (1) ATE124997T1 (da)
AU (1) AU630951B2 (da)
CA (1) CA2016049A1 (da)
DE (1) DE69020794T2 (da)
DK (1) DK0397420T3 (da)
ES (1) ES2075155T3 (da)
HU (1) HU215582B (da)
IE (1) IE67531B1 (da)
IL (1) IL94305A (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
IL104086A (en) * 1991-12-18 1998-03-10 Lilly Co Eli Translational activating oligonucleotide sequence useful for the high level expression of polypeptides and a method for producing such polypeptides
IL104727A (en) * 1992-02-18 1997-01-10 Lilly Co Eli Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
TW257792B (da) * 1992-10-01 1995-09-21 Lilly Co Eli
JP2887060B2 (ja) * 1993-06-30 1999-04-26 日清製粉株式会社 グリセンチンの生産方法
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
JP2887063B2 (ja) * 1993-12-28 1999-04-26 日清製粉株式会社 グリセンチンの製造方法
WO1995030685A1 (en) * 1994-05-09 1995-11-16 Unizyme Laboratories A/S An enzymatic process for producing a desired protein from an amino terminal extended protein
AU698872B2 (en) * 1994-12-29 1998-11-12 Savient Pharmaceuticals, Inc. Generation of human insulin
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
CA2253830A1 (en) * 1996-05-08 1997-11-13 Eli Lilly And Company Bovine dipeptidylaminopeptidase 1
CA2257474A1 (en) * 1996-06-07 1997-12-11 Eli Lilly And Company Ob protein binding protein
DE19943177C2 (de) * 1999-09-09 2002-10-24 Dieter Jenne Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten
IL141647A0 (en) * 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
US7098018B2 (en) * 2001-07-06 2006-08-29 Lg Life Sciences Ltd. Aminopeptidase derived from bacillus licheniformis, gene encoding the aminopeptidase, expression vector containing the gene, transformant and method for preparation thereof
EP2260874A1 (en) * 2003-01-06 2010-12-15 Angiochem Inc. Aprotinin analogs as carriers across the blood-brain barrier
KR20050100616A (ko) 2003-01-14 2005-10-19 테바 파마슈티컬 인더스트리즈 리미티드 전신성 홍반성 낭창의 치료를 위한 펩티드의 비경구 제제
ES2606464T3 (es) * 2003-01-14 2017-03-24 Yeda Research And Development Co. Formulaciones parenterales de péptidos para el tratamiento del lupus eritematoso sistémico
WO2005105830A1 (en) 2004-05-05 2005-11-10 Valorisation-Recherche, Societe En Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
CA2650656A1 (en) 2005-05-05 2007-01-11 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
WO2008144919A1 (en) 2007-05-29 2008-12-04 Angiochem, Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
PT2279008T (pt) 2008-04-18 2019-05-20 Angiochem Inc Composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e utilização
BRPI0920121A2 (pt) 2008-10-15 2019-09-24 Angiochem Inc conjugados de etoposida e doxorubicina para liberação de fármaco
BRPI0920209A2 (pt) 2008-10-15 2015-12-22 Angiochem Inc conjugados de agonistas de glp-1 e usos dos mesmos
EP2370471B1 (en) 2008-12-05 2017-02-22 Angiochem Inc. Neurotensin conjugate and uses thereof
US8853353B2 (en) 2008-12-17 2014-10-07 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
JP5932642B2 (ja) 2009-07-02 2016-06-08 アンジオケム インコーポレーテッド 多量体ペプチドコンジュゲートおよびその使用
EP2588490B1 (en) 2010-07-02 2017-02-22 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
JP6111475B2 (ja) * 2012-12-19 2017-04-12 ウォックハート リミテッド ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物
US11326255B2 (en) 2013-02-07 2022-05-10 Uchicago Argonne, Llc ALD reactor for coating porous substrates
CN107921143B (zh) 2015-06-15 2021-11-19 安吉奥开米公司 用于治疗软脑膜癌病的方法
US11111578B1 (en) 2020-02-13 2021-09-07 Uchicago Argonne, Llc Atomic layer deposition of fluoride thin films
US11901169B2 (en) 2022-02-14 2024-02-13 Uchicago Argonne, Llc Barrier coatings

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
DE3588249T2 (de) * 1984-08-16 2004-05-06 Savient Pharmaceuticals, Inc. Methode zur Herstellung von menschlichen Wachstumshormonen
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
IL91771A0 (en) * 1988-09-30 1990-06-10 Lilly Co Eli Increased expression of small molecular weight recombinant proteins
AU641631B2 (en) * 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
NZ232375A (en) * 1989-02-09 1992-04-28 Lilly Co Eli Insulin analogues modified at b29

Also Published As

Publication number Publication date
AU5483390A (en) 1990-11-15
IE901673L (en) 1990-11-09
US5352769A (en) 1994-10-04
HU902697D0 (en) 1990-09-28
EP0397420A1 (en) 1990-11-14
US5126249A (en) 1992-06-30
HUT54213A (en) 1991-01-28
IL94305A0 (en) 1991-03-10
JPH0334995A (ja) 1991-02-14
DE69020794D1 (de) 1995-08-17
CA2016049A1 (en) 1990-11-09
JP2592981B2 (ja) 1997-03-19
ES2075155T3 (es) 1995-10-01
IE67531B1 (en) 1996-04-03
IL94305A (en) 1995-12-08
HU215582B (hu) 1999-01-28
DE69020794T2 (de) 1995-12-14
ATE124997T1 (de) 1995-07-15
AU630951B2 (en) 1992-11-12
EP0397420B1 (en) 1995-07-12

Similar Documents

Publication Publication Date Title
DK0397420T3 (da) Enzymatisk fjernelse af en aminoterminal proteinsekvens
KR100261030B1 (en) N-terminally chemically modified protein compositions and methods
DE3785864T2 (de) Verfahren zur Herstellung von menschlichem Epidermalwachstumsfaktor und dessen Analogen.
PT88076A (pt) Process for preparing dna vectors of human factor inhibitor
GR3026519T3 (en) New method of treating depression
DE68918246T2 (de) Verbindungen zur Verhinderung von Thrombose.
EP0330700A4 (en) Human prourokinase-like polypeptide.
EP0587571A4 (en) HUMAN GALANINE, cDNA CLONES ENCODING HUMAN GALANINE AND PROCESS FOR PRODUCING HUMAN GALANINE.
DE3561201D1 (en) Medicaments containing tripeptides
HK1031664A1 (en) Use of an organ-specific nutritional composition
BG90414A (bg) 2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им
PT87239A (pt) Process for the preparation of peptides
SE9000793D0 (sv) Sdk-peptider,foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande dem
DE3855751T2 (de) Hypoglycemische peptide
AU542310B2 (en) Glicentin related purified peptide having 30 amino acids
ATE110775T1 (de) Verfahren zur herstellung von hirudin.
FI956247A0 (fi) Uusia menetelmiä (S)-4-amino-hepta-5,6-dieenihappo ja sen välituotteiden valmistamiseksi
ATE101616T1 (de) Verfahren zur herstellung von dipeptiden.
ATE68175T1 (de) Verfahren zur herstellung von l,l oder d,d oder racemat n6 benzyloxycarbonyl 2,6 diaminopimelinsaeuremonoamid.
ATE102950T1 (de) Verfahren zur herstellung von dipeptiden mit cterminalen nicht-proteinogenen aminosaeuren.
IT1283640B1 (it) Procedimento per la preparazione di un acido tetraidrochinolincarbossilico otticamente puro
ATE76081T1 (de) Verfahren zur herstellung von dipeptiden mit nterminalen nichtproteinogenen aminosaeuren.