ATE124997T1 - Enzymatische entfernung einer aminoterminalen proteinsequenz. - Google Patents

Enzymatische entfernung einer aminoterminalen proteinsequenz.

Info

Publication number
ATE124997T1
ATE124997T1 AT90304890T AT90304890T ATE124997T1 AT E124997 T1 ATE124997 T1 AT E124997T1 AT 90304890 T AT90304890 T AT 90304890T AT 90304890 T AT90304890 T AT 90304890T AT E124997 T1 ATE124997 T1 AT E124997T1
Authority
AT
Austria
Prior art keywords
protein sequence
compounds
enzymatic removal
protein
human insulin
Prior art date
Application number
AT90304890T
Other languages
English (en)
Inventor
Gerald Wayne Becker
Thomas Charles Furman
Warren C Mackellar
James Patrick Mcdonough
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE124997T1 publication Critical patent/ATE124997T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AT90304890T 1989-05-09 1990-05-04 Enzymatische entfernung einer aminoterminalen proteinsequenz. ATE124997T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,472 US5126249A (en) 1989-05-09 1989-05-09 Enzymatic removal of a protein amino-terminal sequence

Publications (1)

Publication Number Publication Date
ATE124997T1 true ATE124997T1 (de) 1995-07-15

Family

ID=23372543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90304890T ATE124997T1 (de) 1989-05-09 1990-05-04 Enzymatische entfernung einer aminoterminalen proteinsequenz.

Country Status (12)

Country Link
US (2) US5126249A (de)
EP (1) EP0397420B1 (de)
JP (1) JP2592981B2 (de)
AT (1) ATE124997T1 (de)
AU (1) AU630951B2 (de)
CA (1) CA2016049A1 (de)
DE (1) DE69020794T2 (de)
DK (1) DK0397420T3 (de)
ES (1) ES2075155T3 (de)
HU (1) HU215582B (de)
IE (1) IE67531B1 (de)
IL (1) IL94305A (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
IL104086A (en) * 1991-12-18 1998-03-10 Lilly Co Eli Translational activating oligonucleotide sequence useful for the high level expression of polypeptides and a method for producing such polypeptides
CA2089541A1 (en) * 1992-02-18 1993-08-19 Bruce H. Frank Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
TW257792B (de) * 1992-10-01 1995-09-21 Lilly Co Eli
JP2887060B2 (ja) * 1993-06-30 1999-04-26 日清製粉株式会社 グリセンチンの生産方法
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
JP2887063B2 (ja) * 1993-12-28 1999-04-26 日清製粉株式会社 グリセンチンの製造方法
DK0759931T3 (da) * 1994-05-09 1999-07-12 Unizyme Lab Aps Enzymatisk fremgangsmåde til fremstilling af et ønsket protein ud fra et aminoterminalekstenderet protein
JP4624495B2 (ja) * 1994-12-29 2011-02-02 フェリング・インターナショナル・センター・エス．・エー． ヒト・インスリンの生成
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
EP0898615A1 (de) * 1996-05-08 1999-03-03 Eli Lilly And Company Dipeptidylaminopeptidase aus dem rind
EP0938504A2 (de) * 1996-06-07 1999-09-01 Eli Lilly And Company PROTEIN, WELCHE SICH BINDET AN Ob PROTEIN
DE19943177C2 (de) * 1999-09-09 2002-10-24 Dieter Jenne Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten
IL141647A0 (en) * 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
ATE380863T1 (de) * 2001-07-06 2007-12-15 Lg Life Sciences Ltd Neue, aus bacillus licheniformis stammende aminopeptidase, die aminopeptidase codierendes gen, das gen enthaltender expressionsvektor, transformant sowie verfahren zur herstellung davon
WO2004060403A2 (en) * 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
EA009123B1 (ru) * 2003-01-14 2007-10-26 Тева Фармасьютикал Индастриз, Лтд. Парентеральные композиции пептидов для лечения системной красной волчанки
MXPA05007552A (es) 2003-01-14 2006-05-19 Teva Pharma Formulaciones parenterales de un peptido para el tratamiento de lupus sistemico eritematoso.
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
PL1751175T3 (pl) 2004-05-05 2013-03-29 Valorisation Recherche Soc En Commandite Antagoniści receptora IL-1, kompozycje i sposoby leczenia
EP2366786A3 (de) 2005-05-05 2012-08-29 VALORISATION HSJ, Société en Commandite Zytokin-Rezeptormodulatoren und Verwendung davon
EP2164866B1 (de) 2007-05-29 2014-05-14 Angiochem Inc. Aprotininähnliche polypeptide zum transport von damit konjugierten mitteln in gewebe
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CN102026667B (zh) 2008-04-18 2014-06-25 安吉奥开米公司 紫杉醇、紫杉醇类似物或紫杉醇结合物的药物组合物及相关制备方法和用途
MX2011004019A (es) 2008-10-15 2011-06-24 Angiochem Inc Conjugados de etoposido y doxorubicina para entrega de farmacos.
JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
CA2745524C (en) 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
BRPI0922611A2 (pt) 2008-12-17 2018-11-06 Angiochem Inc inibidores de metaloproteína de matriz de membrana tipo 1 e usos dos mesmos
CA2759129C (en) 2009-04-20 2018-12-11 Angiochem Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
MX2012000016A (es) 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
CA2803646A1 (en) 2010-07-02 2012-01-05 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
JP6111475B2 (ja) * 2012-12-19 2017-04-12 ウォックハート リミテッド ヒトインスリン又はその類似体もしくは誘導体を含む安定な水性組成物
US11326255B2 (en) 2013-02-07 2022-05-10 Uchicago Argonne, Llc ALD reactor for coating porous substrates
ES2826827T3 (es) 2015-06-15 2021-05-19 Angiochem Inc Métodos para el tratamiento de carcinomatosis leptomeníngea
US11111578B1 (en) 2020-02-13 2021-09-07 Uchicago Argonne, Llc Atomic layer deposition of fluoride thin films
US12065738B2 (en) 2021-10-22 2024-08-20 Uchicago Argonne, Llc Method of making thin films of sodium fluorides and their derivatives by ALD
US11901169B2 (en) 2022-02-14 2024-02-13 Uchicago Argonne, Llc Barrier coatings

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
WO1986001229A1 (en) * 1984-08-16 1986-02-27 Bio-Technology General Corp. Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
DK470689A (da) * 1988-09-30 1990-03-31 Lilly Co Eli Hidtil ukendte dna-sekvenser, der koder for protein-derivater, som tillader hoej udtrykkelse af rekombinante proteiner med ringe molekylevaegt
AU641631B2 (en) * 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina

Also Published As

Publication number Publication date
US5126249A (en) 1992-06-30
JP2592981B2 (ja) 1997-03-19
AU630951B2 (en) 1992-11-12
EP0397420B1 (de) 1995-07-12
IL94305A (en) 1995-12-08
HUT54213A (en) 1991-01-28
AU5483390A (en) 1990-11-15
DE69020794D1 (de) 1995-08-17
IE901673L (en) 1990-11-09
EP0397420A1 (de) 1990-11-14
US5352769A (en) 1994-10-04
DE69020794T2 (de) 1995-12-14
DK0397420T3 (da) 1995-08-21
IE67531B1 (en) 1996-04-03
HU215582B (hu) 1999-01-28
HU902697D0 (en) 1990-09-28
ES2075155T3 (es) 1995-10-01
JPH0334995A (ja) 1991-02-14
IL94305A0 (en) 1991-03-10
CA2016049A1 (en) 1990-11-09

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee