ATE124997T1 - Enzymatische entfernung einer aminoterminalen proteinsequenz. - Google Patents

Enzymatische entfernung einer aminoterminalen proteinsequenz.

Info

Publication number
ATE124997T1
ATE124997T1 AT90304890T AT90304890T ATE124997T1 AT E124997 T1 ATE124997 T1 AT E124997T1 AT 90304890 T AT90304890 T AT 90304890T AT 90304890 T AT90304890 T AT 90304890T AT E124997 T1 ATE124997 T1 AT E124997T1
Authority
AT
Austria
Prior art keywords
protein sequence
compounds
enzymatic removal
protein
human insulin
Prior art date
Application number
AT90304890T
Other languages
English (en)
Inventor
Gerald Wayne Becker
Thomas Charles Furman
Warren C Mackellar
James Patrick Mcdonough
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE124997T1 publication Critical patent/ATE124997T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AT90304890T 1989-05-09 1990-05-04 Enzymatische entfernung einer aminoterminalen proteinsequenz. ATE124997T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/349,472 US5126249A (en) 1989-05-09 1989-05-09 Enzymatic removal of a protein amino-terminal sequence

Publications (1)

Publication Number Publication Date
ATE124997T1 true ATE124997T1 (de) 1995-07-15

Family

ID=23372543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90304890T ATE124997T1 (de) 1989-05-09 1990-05-04 Enzymatische entfernung einer aminoterminalen proteinsequenz.

Country Status (12)

Country Link
US (2) US5126249A (de)
EP (1) EP0397420B1 (de)
JP (1) JP2592981B2 (de)
AT (1) ATE124997T1 (de)
AU (1) AU630951B2 (de)
CA (1) CA2016049A1 (de)
DE (1) DE69020794T2 (de)
DK (1) DK0397420T3 (de)
ES (1) ES2075155T3 (de)
HU (1) HU215582B (de)
IE (1) IE67531B1 (de)
IL (1) IL94305A (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93282A (en) * 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
IL104086A (en) * 1991-12-18 1998-03-10 Lilly Co Eli Translational activating oligonucleotide sequence useful for the high level expression of polypeptides and a method for producing such polypeptides
CA2089541A1 (en) * 1992-02-18 1993-08-19 Bruce H. Frank Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1
TW257792B (de) * 1992-10-01 1995-09-21 Lilly Co Eli
JP2887060B2 (ja) * 1993-06-30 1999-04-26 日清製粉株式会社 グリセンチンの生産方法
US5573923A (en) * 1993-12-22 1996-11-12 Eli Lilly And Company Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum
JP2887063B2 (ja) * 1993-12-28 1999-04-26 日清製粉株式会社 グリセンチンの製造方法
ATE172740T1 (de) * 1994-05-09 1998-11-15 Unizyme Lab Aps Ein enzymatisches verfahren zur herstellung eines gewünschten proteins aus einem am aminoterminus verlängerten protein
NZ279002A (en) * 1994-12-29 1999-02-25 Bio Technology General Corp Production of recombinant human insulin by folding a proinsulin hybrid polypeptide obtained from a bacterial cell
US5614379A (en) * 1995-04-26 1997-03-25 Eli Lilly And Company Process for preparing anti-obesity protein
US5840517A (en) * 1995-04-26 1998-11-24 Eli Lilly And Company Process for preparing obesity protein analogs
US6008041A (en) * 1996-05-08 1999-12-28 Eli Lilly And Company Bovine dipeptidylaminopeptidase 1
CA2257474A1 (en) * 1996-06-07 1997-12-11 Eli Lilly And Company Ob protein binding protein
DE19943177C2 (de) * 1999-09-09 2002-10-24 Dieter Jenne Verfahren zur Herstellung von aktiven Serienproteasen und inaktiven Varianten
IL141647A0 (en) * 2001-02-26 2002-03-10 Yeda Res & Dev Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus
CA2451528C (en) * 2001-07-06 2011-08-16 Lg Life Sciences Ltd. Novel aminopeptidase derived from bacillus licheniformis, gene encoding the aminopeptidase, expression vector containing the gene, transformant and method for preparation thereof
ES2368941T3 (es) * 2003-01-06 2011-11-23 Angiochem Inc. Angiopep-1, compuestos relacionados y utilizaciones correspondientes.
UA83816C2 (ru) 2003-01-14 2008-08-26 Тева Фармасьютикал Индастриз, Лтд ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОТОРАЯ СОДЕРЖИТ ПЕПТИД И ЗАМЕЩЕННЫЙ β-ЦИКЛОДЕКСТРИН, ДЛЯ ЛЕЧЕНИЯ СИСТЕМНОЙ КРАСНОЙ ВОЛЧАНКИ
US20050008634A1 (en) * 2003-01-14 2005-01-13 Sharon Cohen-Vered Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
ES2395087T3 (es) 2004-05-05 2013-02-08 Valorisation-Recherche, Société en Commandite Antagonistas del receptor de interleuquina-1, composiciones y métodos de tratamiento
US8618054B2 (en) * 2004-05-05 2013-12-31 Valorisation-Rechereche Société en Commandite Interleukin-1 receptor antagonists, compositions, and methods of treatment
EP2366786A3 (de) 2005-05-05 2012-08-29 VALORISATION HSJ, Société en Commandite Zytokin-Rezeptormodulatoren und Verwendung davon
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
CN101815724B (zh) 2007-05-29 2015-02-25 安吉奥开米公司 用于将轭合至其的试剂递送至组织的抑肽酶样多肽
JP5860698B2 (ja) 2008-04-18 2016-02-16 アンジオケム，インコーポレーテッド パクリタキセル、パクリタキセル類似体またはパクリタキセルコンジュゲートの医薬組成物ならびに関連する調製方法および使用方法
JP5705118B2 (ja) 2008-10-15 2015-04-22 アンジオケム インコーポレーテッド 薬物送達のためのエトポシドおよびドキソルビシン複合体
EP2346906A4 (de) 2008-10-15 2013-04-24 Angiochem Inc Konjugate aus glp-1-agonisten und ihre verwendung
JP5759379B2 (ja) 2008-12-05 2015-08-05 アンジオケム インコーポレーテッド ニューロテンシンまたはニューロテンシンアナログおよびその使用
WO2010069074A1 (en) 2008-12-17 2010-06-24 Universite Du Quebec A Montreal Membrane type-1 matrix metalloprotein inhibitors and uses thereof
EP2421562B1 (de) 2009-04-20 2019-03-13 Angiochem Inc. Behandlung von ovarialkarzinom mit einem an ein angiopep-2-analogon konjugierten antitumorwirkstoff
RU2012103240A (ru) 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
MX360420B (es) * 2012-12-19 2018-10-31 Wockhardt Ltd Una composicion acuosa estable que comprende insulina humana o un analogo o derivado de la misma.
US11326255B2 (en) 2013-02-07 2022-05-10 Uchicago Argonne, Llc ALD reactor for coating porous substrates
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
US11111578B1 (en) 2020-02-13 2021-09-07 Uchicago Argonne, Llc Atomic layer deposition of fluoride thin films
US12065738B2 (en) 2021-10-22 2024-08-20 Uchicago Argonne, Llc Method of making thin films of sodium fluorides and their derivatives by ALD
US11901169B2 (en) 2022-02-14 2024-02-13 Uchicago Argonne, Llc Barrier coatings

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
DE3586773T2 (de) * 1984-08-16 1993-03-18 Bio Technology General Corp Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
PT83613B (en) * 1985-10-28 1988-11-21 Lilly Co Eli Process for the selective chemical removal of a protein amino-terminal residue
DK470689A (da) * 1988-09-30 1990-03-31 Lilly Co Eli Hidtil ukendte dna-sekvenser, der koder for protein-derivater, som tillader hoej udtrykkelse af rekombinante proteiner med ringe molekylevaegt
HUT56857A (en) * 1988-12-23 1991-10-28 Novo Nordisk As Human insulin analogues
IL93282A (en) * 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues

Also Published As

Publication number Publication date
ES2075155T3 (es) 1995-10-01
DE69020794D1 (de) 1995-08-17
JPH0334995A (ja) 1991-02-14
IE67531B1 (en) 1996-04-03
AU630951B2 (en) 1992-11-12
US5126249A (en) 1992-06-30
EP0397420A1 (de) 1990-11-14
IL94305A0 (en) 1991-03-10
IL94305A (en) 1995-12-08
CA2016049A1 (en) 1990-11-09
EP0397420B1 (de) 1995-07-12
HU902697D0 (en) 1990-09-28
IE901673L (en) 1990-11-09
DE69020794T2 (de) 1995-12-14
AU5483390A (en) 1990-11-15
JP2592981B2 (ja) 1997-03-19
DK0397420T3 (da) 1995-08-21
HU215582B (hu) 1999-01-28
HUT54213A (en) 1991-01-28
US5352769A (en) 1994-10-04

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