HUT78070A - Eljárás humán inzulin előállítására - Google Patents
Eljárás humán inzulin előállításáraInfo
- Publication number
- HUT78070A HUT78070A HU9800292A HU9800292A HUT78070A HU T78070 A HUT78070 A HU T78070A HU 9800292 A HU9800292 A HU 9800292A HU 9800292 A HU9800292 A HU 9800292A HU T78070 A HUT78070 A HU T78070A
- Authority
- HU
- Hungary
- Prior art keywords
- human insulin
- generation
- folded
- polypeptide
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9800292A HU223718B1 (hu) | 1994-12-29 | 1994-12-29 | Eljárás humán inzulin előállítására, proinzulin-tartalmú hibridpolipeptid expressziójából kiindulva |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9800292A HU223718B1 (hu) | 1994-12-29 | 1994-12-29 | Eljárás humán inzulin előállítására, proinzulin-tartalmú hibridpolipeptid expressziójából kiindulva |
PCT/US1994/013268 WO1996020724A1 (en) | 1994-12-29 | 1994-12-29 | Generation of human insulin |
Publications (2)
Publication Number | Publication Date |
---|---|
HUT78070A true HUT78070A (hu) | 1999-08-30 |
HU223718B1 HU223718B1 (hu) | 2004-12-28 |
Family
ID=22243290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9800292A HU223718B1 (hu) | 1994-12-29 | 1994-12-29 | Eljárás humán inzulin előállítására, proinzulin-tartalmú hibridpolipeptid expressziójából kiindulva |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0871474B2 (hu) |
JP (1) | JP4624495B2 (hu) |
AT (1) | ATE350053T1 (hu) |
AU (1) | AU698872B2 (hu) |
BR (1) | BR9408638A (hu) |
CA (1) | CA2208095C (hu) |
CZ (1) | CZ290079B6 (hu) |
DE (2) | DE69434909T3 (hu) |
DK (1) | DK0871474T4 (hu) |
ES (1) | ES2279510T5 (hu) |
HK (1) | HK1013594A1 (hu) |
HU (1) | HU223718B1 (hu) |
NZ (1) | NZ279002A (hu) |
PL (1) | PL180818B1 (hu) |
PT (1) | PT871474E (hu) |
WO (1) | WO1996020724A1 (hu) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19735711C2 (de) | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
EP1066328B1 (en) * | 1998-03-31 | 2008-09-17 | Tonghua Gantech Biotechnology Ltd. | Chimeric protein containing an intramolecular chaperone-like sequence and its application to insulin production |
JP3406244B2 (ja) | 1999-04-30 | 2003-05-12 | 伊藤ハム株式会社 | 新規な融合蛋白質からの組み換えインスリンの製造方法 |
EP1265630B1 (en) | 2000-03-24 | 2006-06-07 | Genentech, Inc. | Use of insulin for the treatment of cartilagenous disorders |
US20040037828A1 (en) | 2002-07-09 | 2004-02-26 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
AU2001284364B2 (en) | 2000-07-31 | 2006-09-28 | Bar Ilan University | Methods and pharmaceutical compositions for healing wounds |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
PL212317B1 (pl) | 2003-01-31 | 2012-09-28 | Organon Nv | Sposób izolacji bialka zawierajacego wiazania disulfidowe w natywnej konformacji |
WO2005013885A2 (en) | 2003-08-07 | 2005-02-17 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
WO2012015692A2 (en) * | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
WO2012048856A1 (en) | 2010-10-12 | 2012-04-19 | Glucometrix Pvs Gmbh | Proinsulin with helper sequence |
WO2012098009A1 (en) | 2011-01-21 | 2012-07-26 | Glucometrix Ag | Chimeric polypeptide comprising a membrane protein and an insulin precursor |
WO2013149729A2 (en) | 2012-04-04 | 2013-10-10 | Glucometrix Ag | Proinsulin with enhanced helper sequence |
CA2866491A1 (en) * | 2014-10-02 | 2016-04-02 | Clay Purdy | Synthetic acid compositions and uses thereof |
JP2018531007A (ja) * | 2015-09-24 | 2018-10-25 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリンの製造方法 |
PL239062B1 (pl) * | 2016-01-22 | 2021-11-02 | Inst Biotechnologii I Antybiotykow | Sposób wytwarzania insuliny i jej pochodnych |
US11230585B2 (en) | 2016-09-06 | 2022-01-25 | Chemical & Biopharmaceutical Laboratories Of Patra | Proinsulin derivatives |
US20210230659A1 (en) * | 2018-06-18 | 2021-07-29 | Unichem Laboratories Ltd | Leader Sequence for Higher Expression of Recombinant Proteins |
WO2020069040A1 (en) | 2018-09-25 | 2020-04-02 | Amphastar Pharmaceuticals, Inc. | Highly purified recombinant human insulin (rhi) api and methods of producing the same |
CN113527505A (zh) * | 2020-04-15 | 2021-10-22 | 博锐生物科技有限公司 | 一种多肽和包含该多肽的药物组合物以及它们的应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4430266A (en) * | 1980-11-28 | 1984-02-07 | Eli Lilly And Company | Process for producing an insulin precursor |
DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
US5342921A (en) * | 1985-03-28 | 1994-08-30 | Chiron Corporation | Superoxide dismutase fusion polypeptides for expression of mammalian proteins |
ATE63757T1 (de) † | 1985-03-28 | 1991-06-15 | Chiron Corp | Expression durch verwendung von fusionsgenen fuer proteinproduktion. |
DE3901719A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur herstellung eines insulinvorlaeufers |
DE3901718A1 (de) * | 1989-01-21 | 1990-07-26 | Hoechst Ag | Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern |
US5126249A (en) * | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
US5227293A (en) * | 1989-08-29 | 1993-07-13 | The General Hospital Corporation | Fusion proteins, their preparation and use |
IL104727A (en) * | 1992-02-18 | 1997-01-10 | Lilly Co Eli | Selective removal of n-terminal extensions from folded insulin precursors using dipeptidyl-aminopeptidase-1 |
DE19701167A1 (de) * | 1997-01-15 | 1998-07-23 | Siemens Ag | Chipkarte |
-
1994
- 1994-12-29 PT PT95907193T patent/PT871474E/pt unknown
- 1994-12-29 WO PCT/US1994/013268 patent/WO1996020724A1/en active IP Right Grant
- 1994-12-29 DK DK95907193.7T patent/DK0871474T4/da active
- 1994-12-29 JP JP52090996A patent/JP4624495B2/ja not_active Expired - Lifetime
- 1994-12-29 NZ NZ279002A patent/NZ279002A/xx not_active IP Right Cessation
- 1994-12-29 AT AT95907193T patent/ATE350053T1/de active
- 1994-12-29 ES ES95907193T patent/ES2279510T5/es not_active Expired - Lifetime
- 1994-12-29 HU HU9800292A patent/HU223718B1/hu active IP Right Grant
- 1994-12-29 AU AU15500/95A patent/AU698872B2/en not_active Expired
- 1994-12-29 DE DE69434909T patent/DE69434909T3/de not_active Expired - Lifetime
- 1994-12-29 BR BR9408638-9A patent/BR9408638A/pt not_active Application Discontinuation
- 1994-12-29 EP EP95907193A patent/EP0871474B2/en not_active Expired - Lifetime
- 1994-12-29 CA CA002208095A patent/CA2208095C/en not_active Expired - Lifetime
- 1994-12-29 DE DE95907193T patent/DE95907193T1/de active Pending
- 1994-12-29 PL PL94321039A patent/PL180818B1/pl unknown
- 1994-12-29 CZ CZ19972031A patent/CZ290079B6/cs not_active IP Right Cessation
-
1998
- 1998-09-26 HK HK98110997A patent/HK1013594A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0871474T3 (da) | 2007-05-07 |
BR9408638A (pt) | 2004-09-21 |
ES2279510T3 (es) | 2007-08-16 |
CA2208095C (en) | 2006-11-28 |
NZ279002A (en) | 1999-02-25 |
AU698872B2 (en) | 1998-11-12 |
ES2279510T5 (es) | 2012-01-19 |
AU1550095A (en) | 1996-07-24 |
EP0871474A1 (en) | 1998-10-21 |
DE69434909T2 (de) | 2007-08-09 |
DK0871474T4 (da) | 2012-01-09 |
JP4624495B2 (ja) | 2011-02-02 |
DE69434909T3 (de) | 2012-02-09 |
WO1996020724A1 (en) | 1996-07-11 |
CZ290079B6 (cs) | 2002-05-15 |
ATE350053T1 (de) | 2007-01-15 |
EP0871474A4 (en) | 2004-08-18 |
PT871474E (pt) | 2007-02-28 |
DE95907193T1 (de) | 2005-02-10 |
JPH10511849A (ja) | 1998-11-17 |
CA2208095A1 (en) | 1996-07-11 |
DE69434909D1 (de) | 2007-02-15 |
EP0871474B2 (en) | 2011-09-21 |
HU223718B1 (hu) | 2004-12-28 |
EP0871474B1 (en) | 2007-01-03 |
HK1013594A1 (en) | 1999-09-03 |
PL180818B1 (pl) | 2001-04-30 |
CZ203197A3 (cs) | 1998-09-16 |
PL321039A1 (en) | 1997-11-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HFG4 | Patent granted, date of granting |
Effective date: 20041028 |