JPS646219A - Peptide having promoting action on activation of protein c by thrombin - Google Patents
Peptide having promoting action on activation of protein c by thrombinInfo
- Publication number
- JPS646219A JPS646219A JP63002027A JP202788A JPS646219A JP S646219 A JPS646219 A JP S646219A JP 63002027 A JP63002027 A JP 63002027A JP 202788 A JP202788 A JP 202788A JP S646219 A JPS646219 A JP S646219A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- acid sequence
- activation
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE:To obtain a peptide having a specific amino acid sequence capable of not only promoting activation of protein C to suppress coagulation but also increasing adenization action. CONSTITUTION:A peptide consisting of an amino acid sequence shown by formula or containing the amino acid sequence and an amino acid sequence of at least one other peptide bonded to N-end or C-end of the amino acid sequence. DNA used for producing the peptide by recombinant DNA technology is obtained by preparing cDNA fragment to code part (deficient in N-end) of the peptide from cDNA library made from human lung by using an antibody which is specific to human lung derived peptide capable of promoting protein C activation of thrombin and is obtained from a rabbit and bonding the cDNA fragment a cDNA fragment to code an N-end amino acid sequence prepared by well-known primer extension method.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63002027A JP2738428B2 (en) | 1987-01-08 | 1988-01-08 | Peptides having an action to promote the activation of protein C by thrombin |
Applications Claiming Priority (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP106687 | 1987-01-08 | ||
JP106587 | 1987-01-08 | ||
JP14408187 | 1987-06-11 | ||
JP30587887 | 1987-12-04 | ||
JP62-1065 | 1987-12-04 | ||
JP62-1066 | 1987-12-04 | ||
JP30587687 | 1987-12-04 | ||
JP62-305876 | 1987-12-04 | ||
JP30587787 | 1987-12-04 | ||
JP62-144081 | 1987-12-04 | ||
JP62-305877 | 1987-12-04 | ||
JP62-305878 | 1987-12-04 | ||
JP63002027A JP2738428B2 (en) | 1987-01-08 | 1988-01-08 | Peptides having an action to promote the activation of protein C by thrombin |
Related Child Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6119199A Division JP2766779B2 (en) | 1994-05-31 | 1994-05-31 | DNA encoding a peptide having an action to promote the activation of protein C by thrombin |
JP6119200A Division JP2824392B2 (en) | 1994-05-31 | 1994-05-31 | Culture supernatant containing a peptide having an action of promoting the activation of protein C by thrombin |
JP8138588A Division JP2766473B2 (en) | 1987-01-08 | 1996-05-31 | Peptide promoting the activation of protein C by thrombin |
JP8138589A Division JP2899561B2 (en) | 1987-01-08 | 1996-05-31 | Signal sequence of peptide that promotes protein C activation by thrombin |
JP8138587A Division JP2824418B2 (en) | 1987-01-08 | 1996-05-31 | Pharmaceutical composition containing a peptide having an action of promoting the activation of protein C by thrombin |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS646219A true JPS646219A (en) | 1989-01-10 |
JP2738428B2 JP2738428B2 (en) | 1998-04-08 |
Family
ID=27563108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP63002027A Expired - Lifetime JP2738428B2 (en) | 1987-01-08 | 1988-01-08 | Peptides having an action to promote the activation of protein C by thrombin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2738428B2 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043425A (en) * | 1988-08-29 | 1991-08-27 | Kowa Co., Ltd. | Thrombin-binding protein substance and process for preparing the same |
JPH07155176A (en) * | 1994-05-31 | 1995-06-20 | Asahi Chem Ind Co Ltd | Cultured product containing peptide having activity to promote activation of protein c by thrombin |
JPH07163369A (en) * | 1994-05-31 | 1995-06-27 | Asahi Chem Ind Co Ltd | Dna coding peptide having promotion effect of protein c activation of thrombin |
WO1997037018A1 (en) * | 1996-04-03 | 1997-10-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel gene |
WO1998001153A1 (en) * | 1996-07-03 | 1998-01-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Medicinal compositions for extracorporeal blood circulation circuit and method for inhibiting blood coagulation in extracorporeal blood circulation circuit |
US5834028A (en) * | 1993-12-17 | 1998-11-10 | Mochida Pharmaceutical Co., Ltd. | Soluble thrombomodulin-containing composition |
WO1999018994A1 (en) * | 1997-10-15 | 1999-04-22 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution |
JP2002012218A (en) * | 2000-06-28 | 2002-01-15 | Dainippon Printing Co Ltd | Carton with a plurality of housings |
JP2006271809A (en) * | 2005-03-30 | 2006-10-12 | Toray Ind Inc | Irradiated modified base material |
US8258269B2 (en) | 2007-03-23 | 2012-09-04 | Asahi Kasei Pharma Corporation | Method for producing high-purity soluble thrombomodulin |
WO2013073545A1 (en) | 2011-11-15 | 2013-05-23 | 旭化成ファーマ株式会社 | Medicine for treatment and/or improvement of sepsis |
WO2013179910A1 (en) | 2012-05-31 | 2013-12-05 | 学校法人近畿大学 | Agent for preventing and/or treating peripheral neuropathic pain caused by anti-cancer drug |
US9127089B2 (en) | 2010-04-30 | 2015-09-08 | Asahi Kasei Pharma Corporation | Highly-purified soluble thrombomodulin and method for producing same |
WO2020067389A1 (en) | 2018-09-28 | 2020-04-02 | 旭化成ファーマ株式会社 | Medication for alleviating symptoms of peripheral neuropathy caused by anticancer drug and/or suppressing onset of peripheral neuropathy |
WO2020084853A1 (en) | 2018-10-22 | 2020-04-30 | 旭化成ファーマ株式会社 | Drug for treating and/or improving septicemia associated with coagulation abnormality |
US11497795B2 (en) | 2018-09-28 | 2022-11-15 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
-
1988
- 1988-01-08 JP JP63002027A patent/JP2738428B2/en not_active Expired - Lifetime
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5043425A (en) * | 1988-08-29 | 1991-08-27 | Kowa Co., Ltd. | Thrombin-binding protein substance and process for preparing the same |
US5834028A (en) * | 1993-12-17 | 1998-11-10 | Mochida Pharmaceutical Co., Ltd. | Soluble thrombomodulin-containing composition |
JPH07155176A (en) * | 1994-05-31 | 1995-06-20 | Asahi Chem Ind Co Ltd | Cultured product containing peptide having activity to promote activation of protein c by thrombin |
JPH07163369A (en) * | 1994-05-31 | 1995-06-27 | Asahi Chem Ind Co Ltd | Dna coding peptide having promotion effect of protein c activation of thrombin |
WO1997037018A1 (en) * | 1996-04-03 | 1997-10-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel gene |
WO1998001153A1 (en) * | 1996-07-03 | 1998-01-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Medicinal compositions for extracorporeal blood circulation circuit and method for inhibiting blood coagulation in extracorporeal blood circulation circuit |
WO1999018994A1 (en) * | 1997-10-15 | 1999-04-22 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution |
JP2002012218A (en) * | 2000-06-28 | 2002-01-15 | Dainippon Printing Co Ltd | Carton with a plurality of housings |
JP2006271809A (en) * | 2005-03-30 | 2006-10-12 | Toray Ind Inc | Irradiated modified base material |
US8258269B2 (en) | 2007-03-23 | 2012-09-04 | Asahi Kasei Pharma Corporation | Method for producing high-purity soluble thrombomodulin |
US8952137B2 (en) | 2007-03-23 | 2015-02-10 | Asahi Kasei Pharma Corporation | Method for producing high-purity soluble thrombomodulin |
EP3150628A1 (en) | 2010-04-30 | 2017-04-05 | Asahi Kasei Pharma Corporation | Highly-purified soluble thrombomodulin |
US9127089B2 (en) | 2010-04-30 | 2015-09-08 | Asahi Kasei Pharma Corporation | Highly-purified soluble thrombomodulin and method for producing same |
US8772239B2 (en) | 2011-11-15 | 2014-07-08 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis |
KR20140095559A (en) | 2011-11-15 | 2014-08-01 | 아사히 가세이 파마 가부시키가이샤 | Medicament for therapeutic treatment and/or improvement of sepsis |
US9034823B2 (en) | 2011-11-15 | 2015-05-19 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis |
US9555080B2 (en) | 2011-11-15 | 2017-01-31 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis |
US9592275B2 (en) | 2011-11-15 | 2017-03-14 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis |
WO2013073545A1 (en) | 2011-11-15 | 2013-05-23 | 旭化成ファーマ株式会社 | Medicine for treatment and/or improvement of sepsis |
KR20150004855A (en) | 2012-05-31 | 2015-01-13 | 갓코 호진 긴키 다이가쿠 | Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent |
WO2013179910A1 (en) | 2012-05-31 | 2013-12-05 | 学校法人近畿大学 | Agent for preventing and/or treating peripheral neuropathic pain caused by anti-cancer drug |
US10709767B2 (en) | 2012-05-31 | 2020-07-14 | Kinki University | Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent |
WO2020067389A1 (en) | 2018-09-28 | 2020-04-02 | 旭化成ファーマ株式会社 | Medication for alleviating symptoms of peripheral neuropathy caused by anticancer drug and/or suppressing onset of peripheral neuropathy |
US11497795B2 (en) | 2018-09-28 | 2022-11-15 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
WO2020084853A1 (en) | 2018-10-22 | 2020-04-30 | 旭化成ファーマ株式会社 | Drug for treating and/or improving septicemia associated with coagulation abnormality |
KR20210060574A (en) | 2018-10-22 | 2021-05-26 | 아사히 가세이 파마 가부시키가이샤 | Medications for the treatment and/or amelioration of sepsis with coagulation abnormalities |
Also Published As
Publication number | Publication date |
---|---|
JP2738428B2 (en) | 1998-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EXPY | Cancellation because of completion of term |