JPS646219A - Peptide having promoting action on activation of protein c by thrombin - Google Patents

Peptide having promoting action on activation of protein c by thrombin

Info

Publication number
JPS646219A
JPS646219A JP63002027A JP202788A JPS646219A JP S646219 A JPS646219 A JP S646219A JP 63002027 A JP63002027 A JP 63002027A JP 202788 A JP202788 A JP 202788A JP S646219 A JPS646219 A JP S646219A
Authority
JP
Japan
Prior art keywords
peptide
amino acid
acid sequence
activation
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63002027A
Other languages
Japanese (ja)
Other versions
JP2738428B2 (en
Inventor
Shuji Yamamoto
Koji Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27563108&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS646219(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP63002027A priority Critical patent/JP2738428B2/en
Publication of JPS646219A publication Critical patent/JPS646219A/en
Application granted granted Critical
Publication of JP2738428B2 publication Critical patent/JP2738428B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE:To obtain a peptide having a specific amino acid sequence capable of not only promoting activation of protein C to suppress coagulation but also increasing adenization action. CONSTITUTION:A peptide consisting of an amino acid sequence shown by formula or containing the amino acid sequence and an amino acid sequence of at least one other peptide bonded to N-end or C-end of the amino acid sequence. DNA used for producing the peptide by recombinant DNA technology is obtained by preparing cDNA fragment to code part (deficient in N-end) of the peptide from cDNA library made from human lung by using an antibody which is specific to human lung derived peptide capable of promoting protein C activation of thrombin and is obtained from a rabbit and bonding the cDNA fragment a cDNA fragment to code an N-end amino acid sequence prepared by well-known primer extension method.
JP63002027A 1987-01-08 1988-01-08 Peptides having an action to promote the activation of protein C by thrombin Expired - Lifetime JP2738428B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63002027A JP2738428B2 (en) 1987-01-08 1988-01-08 Peptides having an action to promote the activation of protein C by thrombin

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
JP106687 1987-01-08
JP106587 1987-01-08
JP14408187 1987-06-11
JP30587887 1987-12-04
JP62-1065 1987-12-04
JP62-1066 1987-12-04
JP30587687 1987-12-04
JP62-305876 1987-12-04
JP30587787 1987-12-04
JP62-144081 1987-12-04
JP62-305877 1987-12-04
JP62-305878 1987-12-04
JP63002027A JP2738428B2 (en) 1987-01-08 1988-01-08 Peptides having an action to promote the activation of protein C by thrombin

Related Child Applications (5)

Application Number Title Priority Date Filing Date
JP6119199A Division JP2766779B2 (en) 1994-05-31 1994-05-31 DNA encoding a peptide having an action to promote the activation of protein C by thrombin
JP6119200A Division JP2824392B2 (en) 1994-05-31 1994-05-31 Culture supernatant containing a peptide having an action of promoting the activation of protein C by thrombin
JP8138588A Division JP2766473B2 (en) 1987-01-08 1996-05-31 Peptide promoting the activation of protein C by thrombin
JP8138589A Division JP2899561B2 (en) 1987-01-08 1996-05-31 Signal sequence of peptide that promotes protein C activation by thrombin
JP8138587A Division JP2824418B2 (en) 1987-01-08 1996-05-31 Pharmaceutical composition containing a peptide having an action of promoting the activation of protein C by thrombin

Publications (2)

Publication Number Publication Date
JPS646219A true JPS646219A (en) 1989-01-10
JP2738428B2 JP2738428B2 (en) 1998-04-08

Family

ID=27563108

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63002027A Expired - Lifetime JP2738428B2 (en) 1987-01-08 1988-01-08 Peptides having an action to promote the activation of protein C by thrombin

Country Status (1)

Country Link
JP (1) JP2738428B2 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043425A (en) * 1988-08-29 1991-08-27 Kowa Co., Ltd. Thrombin-binding protein substance and process for preparing the same
JPH07155176A (en) * 1994-05-31 1995-06-20 Asahi Chem Ind Co Ltd Cultured product containing peptide having activity to promote activation of protein c by thrombin
JPH07163369A (en) * 1994-05-31 1995-06-27 Asahi Chem Ind Co Ltd Dna coding peptide having promotion effect of protein c activation of thrombin
WO1997037018A1 (en) * 1996-04-03 1997-10-09 Asahi Kasei Kogyo Kabushiki Kaisha Novel gene
WO1998001153A1 (en) * 1996-07-03 1998-01-15 Asahi Kasei Kogyo Kabushiki Kaisha Medicinal compositions for extracorporeal blood circulation circuit and method for inhibiting blood coagulation in extracorporeal blood circulation circuit
US5834028A (en) * 1993-12-17 1998-11-10 Mochida Pharmaceutical Co., Ltd. Soluble thrombomodulin-containing composition
WO1999018994A1 (en) * 1997-10-15 1999-04-22 Asahi Kasei Kogyo Kabushiki Kaisha Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution
JP2002012218A (en) * 2000-06-28 2002-01-15 Dainippon Printing Co Ltd Carton with a plurality of housings
JP2006271809A (en) * 2005-03-30 2006-10-12 Toray Ind Inc Irradiated modified base material
US8258269B2 (en) 2007-03-23 2012-09-04 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
WO2013073545A1 (en) 2011-11-15 2013-05-23 旭化成ファーマ株式会社 Medicine for treatment and/or improvement of sepsis
WO2013179910A1 (en) 2012-05-31 2013-12-05 学校法人近畿大学 Agent for preventing and/or treating peripheral neuropathic pain caused by anti-cancer drug
US9127089B2 (en) 2010-04-30 2015-09-08 Asahi Kasei Pharma Corporation Highly-purified soluble thrombomodulin and method for producing same
WO2020067389A1 (en) 2018-09-28 2020-04-02 旭化成ファーマ株式会社 Medication for alleviating symptoms of peripheral neuropathy caused by anticancer drug and/or suppressing onset of peripheral neuropathy
WO2020084853A1 (en) 2018-10-22 2020-04-30 旭化成ファーマ株式会社 Drug for treating and/or improving septicemia associated with coagulation abnormality
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043425A (en) * 1988-08-29 1991-08-27 Kowa Co., Ltd. Thrombin-binding protein substance and process for preparing the same
US5834028A (en) * 1993-12-17 1998-11-10 Mochida Pharmaceutical Co., Ltd. Soluble thrombomodulin-containing composition
JPH07155176A (en) * 1994-05-31 1995-06-20 Asahi Chem Ind Co Ltd Cultured product containing peptide having activity to promote activation of protein c by thrombin
JPH07163369A (en) * 1994-05-31 1995-06-27 Asahi Chem Ind Co Ltd Dna coding peptide having promotion effect of protein c activation of thrombin
WO1997037018A1 (en) * 1996-04-03 1997-10-09 Asahi Kasei Kogyo Kabushiki Kaisha Novel gene
WO1998001153A1 (en) * 1996-07-03 1998-01-15 Asahi Kasei Kogyo Kabushiki Kaisha Medicinal compositions for extracorporeal blood circulation circuit and method for inhibiting blood coagulation in extracorporeal blood circulation circuit
WO1999018994A1 (en) * 1997-10-15 1999-04-22 Asahi Kasei Kogyo Kabushiki Kaisha Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution
JP2002012218A (en) * 2000-06-28 2002-01-15 Dainippon Printing Co Ltd Carton with a plurality of housings
JP2006271809A (en) * 2005-03-30 2006-10-12 Toray Ind Inc Irradiated modified base material
US8258269B2 (en) 2007-03-23 2012-09-04 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
US8952137B2 (en) 2007-03-23 2015-02-10 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
EP3150628A1 (en) 2010-04-30 2017-04-05 Asahi Kasei Pharma Corporation Highly-purified soluble thrombomodulin
US9127089B2 (en) 2010-04-30 2015-09-08 Asahi Kasei Pharma Corporation Highly-purified soluble thrombomodulin and method for producing same
US8772239B2 (en) 2011-11-15 2014-07-08 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
KR20140095559A (en) 2011-11-15 2014-08-01 아사히 가세이 파마 가부시키가이샤 Medicament for therapeutic treatment and/or improvement of sepsis
US9034823B2 (en) 2011-11-15 2015-05-19 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
US9555080B2 (en) 2011-11-15 2017-01-31 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
US9592275B2 (en) 2011-11-15 2017-03-14 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
WO2013073545A1 (en) 2011-11-15 2013-05-23 旭化成ファーマ株式会社 Medicine for treatment and/or improvement of sepsis
KR20150004855A (en) 2012-05-31 2015-01-13 갓코 호진 긴키 다이가쿠 Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
WO2013179910A1 (en) 2012-05-31 2013-12-05 学校法人近畿大学 Agent for preventing and/or treating peripheral neuropathic pain caused by anti-cancer drug
US10709767B2 (en) 2012-05-31 2020-07-14 Kinki University Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
WO2020067389A1 (en) 2018-09-28 2020-04-02 旭化成ファーマ株式会社 Medication for alleviating symptoms of peripheral neuropathy caused by anticancer drug and/or suppressing onset of peripheral neuropathy
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
WO2020084853A1 (en) 2018-10-22 2020-04-30 旭化成ファーマ株式会社 Drug for treating and/or improving septicemia associated with coagulation abnormality
KR20210060574A (en) 2018-10-22 2021-05-26 아사히 가세이 파마 가부시키가이샤 Medications for the treatment and/or amelioration of sepsis with coagulation abnormalities

Also Published As

Publication number Publication date
JP2738428B2 (en) 1998-04-08

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